Traditional Chinese medicine composition for treating infantile adenoid hypertrophy and preparation method thereof

Abstract

The embodiment of the invention discloses a traditional Chinese medicine composition for treating infantile adenoid hypertrophy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition for treating infantile adenoid hypertrophy. The traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 6-10 parts of lophatherum gracile, 6-10 parts of radix rehmanniae recen, 3-6 parts of tetrapanax papyriferus, 6-15 parts of poria cocos, 6-10 parts of polyporus umbellatus, 6-7 parts of rhizoma alismatis, 5-6 parts of cassia twig, 6-10 parts of roasted rhizoma atractylodis macrocephalae, 10-15 parts of plantain herb and 9-10 parts of Chinese dates. The traditional Chinese medicine composition provided by the invention can be used for rapidly relieving clinical symptoms such as sleep snoring, mouth breathing, nasal obstruction and the like aiming at the infantile adenoid hypertrophy disease, remarkably reduces the hypertrophy gland volume, is definite in curative effect and high in safety, and has a good clinical application value and a good popularization prospect.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and particularly to a traditional Chinese medicine composition for treating adenoid hypertrophy in children and a preparation method thereof. Background Art

[0002] Adenoids hypertrophy in children is a common pediatric disease, mostly occurring in children aged 2-12 years. Clinical manifestations include snoring during sleep, mouth breathing, and nasal congestion. In severe cases, it can cause respiratory arrest. In the long term, it can also affect the child's growth, intellectual development, and maxillofacial bone development, and even lead to chronic hypoxia syndrome. Currently, clinical treatment for adenoids hypertrophy in children mainly includes drug therapy and surgical treatment. Drug treatment mostly uses glucocorticoids and antihistamines. Glucocorticoids reduce adenoid inflammation and swelling through anti-inflammatory and anti-immune effects, while antihistamines can relieve related symptoms caused by allergies. This method has the advantages of relatively fast onset and no invasive procedures. However, long-term use can affect children's growth and development, reduce the body's immunity, and easily lead to symptom rebound after drug discontinuation. Surgical treatment mainly involves adenoidectomy, which can quickly resolve airway obstruction and fundamentally remove the diseased tissue. It is very effective for children with severely obstructed airways. However, the surgery is invasive, has the risk of postoperative bleeding and infection, and has a high risk of recurrence. Therefore, it is generally not accepted by children and parents.

[0003] Traditional Chinese Medicine (TCM) believes that adenoid hypertrophy in children is closely related to dysfunction of the lungs, spleen, and kidneys. Existing TCM treatments often focus on overall well-being, primarily promoting lung function, strengthening the spleen and resolving phlegm, and nourishing the kidneys and replenishing essence. However, clinical practice has revealed that existing TCM combinations have varying efficacy, long treatment cycles, and insignificant symptom improvement in some children. Summary of the Invention

[0004] To this end, the present invention provides a Chinese medicine composition for treating adenoid hypertrophy in children and a preparation method thereof.

[0005] In order to achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0006] According to a first aspect of an embodiment of the present invention, the present invention provides a traditional Chinese medicine composition for treating adenoids hypertrophy in children, wherein the traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 6-10 parts of light bamboo leaves, 6-10 parts of raw rehmannia, 3-6 parts of tongcao, 6-15 parts of tuckahoe, 6-10 parts of umbellatus, 6-7 parts of oriental dwarfism, 5-6 parts of cinnamon twig, 6-10 parts of stir-fried atractylodes, 10-15 parts of plantain, and 9-10 parts of jujube.

[0007] Furthermore, the Chinese medicine composition also includes 6 to 10 parts of salt orange seeds, 6 to 10 parts of salt lychee seeds, and 6 to 10 parts of thunbergii bulbs.

[0008] Furthermore, the traditional Chinese medicine composition also includes 6 to 10 portions of raw dragon bones.

[0009] Furthermore, the traditional Chinese medicine composition also includes 6 to 15 parts of astragalus and 6 to 10 parts of white peony root.

[0010] Furthermore, the traditional Chinese medicine composition also includes 9 to 10 parts of Forsythia suspensa and 6 to 10 parts of stir-fried Xanthium sibiricum fruit.

[0011] Furthermore, the traditional Chinese medicine composition also includes 10 to 15 parts of Morus alba bark and 10 to 15 parts of Lepidium tiliaceum seeds.

[0012] According to a second aspect of an embodiment of the present invention, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating adenoids hypertrophy in children, wherein the medicinal materials are mixed, soaked in water, decocted, and filtered to obtain the traditional Chinese medicine composition.

[0013] According to a third aspect of the embodiments of the present invention, the present invention provides use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating adenoid hypertrophy in children.

[0014] The usage, dosage, and additions and subtractions of the Chinese medicine composition for treating adenoids hypertrophy in children provided by the present invention are described as follows:

[0015] ① Usage and dosage of Chinese medicine:

[0016] The traditional Chinese medicine prescription provided by the present invention comprises: 6-10g of bamboo leaves, 6-10g of raw rehmannia root, 3-6g of tongcao, 6-15g of tuckahoe, 6-10g of umbellatus, 6-7g of oriental rhizome, 5-6g of cinnamon twig, 6-10g of stir-fried atractylodes macrocephala, 10-15g of plantain, and 9-10 parts of jujube. Add water and boil to obtain about 200ml of decoction.

[0017] The above dosage is suitable for children aged 3-10 years. Dosage: School-age children (7-10 years old) should take 100ml twice a day after meals; preschool children (3-7 years old) should take 200ml daily, 3-4 times a day, 50-80ml each time.

[0018] ② Addition and subtraction of Chinese medicine:

[0019] For patients with severe phlegm-dampness, with symptoms of long-term glandular hypertrophy and no obvious glandular congestion or blood stasis, add 6-10g of salted orange seeds, 6-10g of salted litchi seeds, and 6-10g of Zhejiang Fritillaria to resolve phlegm and dissipate stagnation.

[0020] If liver heat is obvious, with symptoms such as irritability, slow falling asleep, and restless sleep, add 6-10g of raw dragon bone to calm the liver and suppress yang.

[0021] When the lung defense is insufficient and the Ying and Wei are not in harmony, symptoms include susceptibility to colds and excessive sweating. 6-15g of Astragalus and 6-10g of White Peony can be added to harmonize the Ying and Wei.

[0022] For patients with rhinitis, add 9-10g of Forsythia suspensa and 6-10g of stir-fried Xanthium sibiricum.

[0023] When combined with secretory otitis media, add 10-15g of Morus alba bark and 10-15g of Trichosanthes kirilowii seeds to clear the lungs, promote diuresis and open the orifices.

[0024] The embodiments of the present invention have the following advantages:

[0025] The applicant's research found that the core pathogenesis of adenoid hypertrophy in children is "small intestine heat and bladder cold". Food intolerance, heart fire moving down to the small intestine, and spleen dysfunction lead to endogenous heat in the small intestine; large body fluid content and repeated colds in children affect the qi transformation of the bladder meridian, resulting in a state of bladder deficiency and cold. To this end, the Chinese medicine composition provided by the present invention uses light bamboo leaves, raw rehmannia, tongcao, tuckahoe, umbelliferae, oriental rhizome, cinnamon twig, stir-fried white atractylodes, plantain and jujube as raw materials, among which the main drugs light bamboo leaves, raw rehmannia and tongcao in Daochi San are all monarch drugs, which clear away heat and nourish yin, promote diuresis and relieve stranguria, and relieve heat in the small intestine and heart meridians, mainly in the hand-taiyang meridian; tuckahoe, umbelliferae, oriental rhizome, white atractylodes and cinnamon twig in Wuling San are all minister drugs, which warm yang and transform qi, promote diuresis and eliminate dampness, and are effective in diseases of the foot-taiyang meridian and viscera; plantain enters the liver and bladder meridians, can clear away heat and dampness, eliminate phlegm and disperse stagnation, and is an adjuvant drug to strengthen the efficacy of the monarch and minister drugs; jujube is a harmonious drug, which strengthens the spleen and stomach. The combined use of the above herbs clears heat from the Hand-Taiyang Small Intestine Meridian and warms the Foot-Taiyang Bladder Meridian, removing heat and transforming dampness, restoring the Qi flow to normal, and rapidly alleviating the patient's symptoms. Clinical practice has demonstrated that the traditional Chinese medicine composition provided by the present invention can rapidly alleviate clinical symptoms such as snoring, mouth breathing, and nasal congestion in children with adenoid hypertrophy, significantly reducing the volume of the enlarged glands. It has a definite therapeutic effect and high safety, and has excellent clinical application value and promotion prospects. DETAILED DESCRIPTION

[0026] The following describes the implementation of the present invention using specific embodiments. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. Obviously, the embodiments described are only a portion of the present invention, not all of it. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort are intended to fall within the scope of protection of the present invention.

[0027] Example 1

[0028] This embodiment provides a traditional Chinese medicine composition for treating adenoids hypertrophy in children, the raw materials of which are: 6g of light bamboo leaves, 6g of raw rehmannia root, 3g of tongcao, 6g of tuckahoe, 6g of umbellate, 6g of oriental water chestnut, 6g of cinnamon twig, 6g of stir-fried atractylodes, 10g of plantain, and 10g of jujube.

[0029] The preparation method of the above-mentioned traditional Chinese medicine composition comprises: soaking all medicines for half an hour, adding water for decocting, decocting over high heat until the water boils, decocting over low heat for 30-40 minutes, filtering, and obtaining about 200 ml of decoction.

[0030] Example 2

[0031] This embodiment provides a traditional Chinese medicine composition for treating adenoids hypertrophy in children, the raw materials of which are: 10g of light bamboo leaves, 10g of raw rehmannia root, 6g of tongcao, 15g of tuckahoe, 10g of umbellate, 6g of oriental water chestnut, 6g of cinnamon twig, 10g of stir-fried atractylodes, 15g of plantain, and 10g of jujube.

[0032] The preparation method of the above-mentioned traditional Chinese medicine composition comprises: soaking all medicines for half an hour, adding water for decocting, decocting over high heat until the water boils, decocting over low heat for 30-40 minutes, filtering, and obtaining about 200 ml of decoction.

[0033] clinical trials

[0034] In order to verify the therapeutic effect of the Chinese medicine composition provided by the present invention on adenoids hypertrophy in children, the following content is provided.

[0035] Clinical data:

[0036] Based on the real-world research model, a prospective cohort study method was used. From March 1, 2023 to March 1, 2024, children with adenoids hypertrophy who met the inclusion criteria were recruited from the otolaryngology outpatient clinic of Xiyuan Hospital. Baseline data were collected, and according to the general situation questionnaire, fiber nasopharyngeal endoscopy before and after treatment, symptom and sign and auxiliary examination assessment form, quality of life score form, etc., after two weeks of drug treatment, the efficacy of the traditional Chinese medicine treatment group and the western medicine treatment group in the treatment of adenoids hypertrophy in children was compared, and the intervention effect of traditional Chinese medicine treatment on adenoids hypertrophy in children was comprehensively evaluated.

[0037] Diagnostic criteria:

[0038] The Western medicine diagnostic criteria for this study were formulated with reference to the Practical Otorhinolaryngology and Head and Neck Surgery edited by Huang Xuanzhao et al., the textbook Otorhinolaryngology and Head and Neck Surgery edited by Kong Weijia et al., the Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea in Children in China (2020), and related literature:

[0039] (1) Main symptoms: nasal congestion, mouth breathing, snoring during sleep, and sleep apnea.

[0040] (2) Secondary symptoms: Ear symptoms include ear obstruction, hearing loss, tinnitus, etc.; nasal symptoms include nasal congestion, runny nose, etc.; pharyngeal, larynx and lower respiratory tract symptoms include chronic cough, frequent throat clearing, sore throat, hiccups, etc.; systemic symptoms include slow falling asleep, frequent dreams, night terrors, abdominal pain, indigestion, slow growth and development, inattention, memory loss, and sometimes "adenoid facies".

[0041] (3) Physical signs: Adenoid hyperplasia can be seen in the nasopharynx, and palatine tonsil hypertrophy can be seen in the oropharynx; after full convergence of the nasal mucosa during anterior rhinoscopy, red lumpy protrusions can be seen in the nasopharynx in some children.

[0042] (4) Auxiliary examinations:

[0043] Indirect nasopharyngoscopy, fiberoptic nasopharyngoscopy, and nasal endoscopy: Red, blocky ridges can be seen on the posterior wall of the nasopharynx, often with an orange-segmented surface and 5 to 6 deep longitudinal grooves, in which pus or debris can sometimes be seen. Diagnosis and grading criteria:

[0044] Grade I obstruction: Adenoids block less than 25% of the posterior nasal passage;

[0045] Grade II obstruction: Adenoids block the posterior nasal passages by 26% to 50%;

[0046] Grade III obstruction: Adenoids block the posterior nasal passages by 51% to 75%;

[0047] Grade IV obstruction: Adenoids block the posterior nasal passages by 76% to 100%;

[0048] *Grade III and above are accompanied by clinical symptoms of adenoid hypertrophy.

[0049] If one or more of the symptoms in (1) and grade III or higher obstruction in (4) are met at the same time, the child can be diagnosed with adenoid hypertrophy.

[0050] Inclusion criteria:

[0051] (1) Those who meet the above-mentioned Western medical diagnostic criteria for pediatric AH;

[0052] (2) Aged 3-10 years old;

[0053] (3) Sign the informed consent form.

[0054] Inclusion criteria:

[0055] (1) Children with breathing difficulties caused by childhood obesity, nasal polyps, nasal septum deviation, and other reasons;

[0056] (2) Severe sleep disturbance, combined with serious primary diseases of the heart, brain, lung, liver, kidney, hematopoietic system, etc.;

[0057] (3) Children with severe malnutrition, functional impairment, severe rickets, and mental illness;

[0058] (4) Those who cannot complete auxiliary examinations or follow-up due to various reasons.

[0059] Treatment:

[0060] ① The above dosage of Chinese medicine is suitable for school-age children (7-10 years old), take 100 ml twice a day after each meal; preschool children (3-7 years old) should take 2 / 3 of the above dosage, take 200 ml per day, 3-4 times a day, 50-80 ml each time.

[0061] ② Addition and subtraction of Chinese medicine:

[0062] For patients with severe phlegm-dampness, with symptoms of long-term glandular hypertrophy and no obvious glandular congestion or blood stasis, add 6g of salted orange seeds, 6g of salted litchi seeds, and 6g of Zhejiang Fritillaria to resolve phlegm and dissipate stagnation.

[0063] If liver heat is obvious, with symptoms such as irritability, slow falling asleep, and restless sleep, add 10g of raw dragon bone to calm the liver and suppress yang.

[0064] When the lung defense is insufficient and the Ying and Wei are not in harmony, symptoms include susceptibility to colds and excessive sweating. 15g of Astragalus and 10g of White Peony can be added to harmonize the Ying and Wei.

[0065] For patients with rhinitis, add 10g of Forsythia suspensa and 6g of stir-fried Xanthium sibiricum.

[0066] When combined with secretory otitis media, add 10g of Morus alba bark and 10g of Trichosanthes kirilowii to drain the lungs, promote diuresis and open the orifices.

[0067] Treatment course: two weeks.

[0068] Observation indicators: Symptom and sign scoring scale before and after treatment, fiberoptic nasopharyngeal endoscopy, and children's adenoid hypertrophy quality of life questionnaire.

[0069] Efficacy evaluation criteria:

[0070] (1) Calculation and grading of scores before and after treatment:

[0071] According to the "Guiding Principles for Clinical Research of New Chinese Medicines", the efficacy grading method was used, and the grading standards are shown in Table 1. The calculation formula is: efficacy index (p) = (pre-treatment score - post-treatment score) / pre-treatment score × 100%.

[0072] Table 1

[0073]

[0074]

[0075] *Note: Cases that are cured, markedly effective, or effective are all considered “effective treatment.”

[0076] (2) Total effective rate: Total effective rate = number of effective cases × 100% / total number of cases

[0077] The results are shown in Table 2 below.

[0078] Table 2

[0079]

[0080] The results showed that the short-term efficacy rate of the traditional Chinese medicine treatment group provided by the present invention with Daochi San combined with Wuling San as the main prescription was 54.1%, which was more advantageous than the Western medicine treatment group (short-term efficacy rate of 22.2%) in improving the size of adenotonsils, microscopic manifestations and overall condition of the disease.

[0081] Typical cases:

[0082] 1. The patient is a 4-year-old girl. She was admitted to the hospital on December 30, 2021. Chief complaint: recurrent nasal congestion, snoring, and mouth breathing for more than 3 months. Current medical history: The patient had recurrent nasal congestion, snoring, and mouth breathing 3 months ago. After examination at an external hospital, she was diagnosed with "adenoid hypertrophy". She had been treated with nasal spray hormones and other treatments, and the symptoms were slightly relieved, but unstable. Occasional sneezing, no runny nose, no cough, and no sputum. Appetite is good, but sleep is not sound. Irritable, with occasional skin itching and obvious dark circles. Physical examination: The pharyngeal mucosa is slightly congested, and the tonsils are not large. The nasal mucosa is slightly congested, and the middle and inferior turbinates are not swollen. The tongue is red, with red spots on the upper part of the tongue, thick and greasy white fur on the lower part, floating pulse on the left inch, slippery and turbid pulse on the right guan, and floating pulse on the chi. Auxiliary examination: Fiber nasopharyngeal endoscopy: The child's nasopharyngeal roof has a bulge of orange-slice-like tissue, about 3 / 4 of the posterior nostril, and the surface is swollen. Western medicine diagnosis: adenoid hypertrophy. Traditional Chinese medicine diagnosis: snoring. Syndrome differentiation: excessive small intestinal heat, Taiyang meridian syndrome. Treatment: Clear damp-heat in the small intestine, promote qi, unblock yang, and disperse stagnation. Prescription: 6g of light bamboo leaves, 6g of raw rehmannia root, 3g of tongcao, 6g of tuckahoe, 6g of umbelliferae, 6g of oriental dwarfism, 6g of stir-fried atractylodes, 6g of cinnamon twig, 6g of salted orange seed, 6g of salted litchi seed, 10g of plantain, 10g of forsythia, 6g of stir-fried Xanthium sibiricum fruit, 6g of roasted astragalus, 6g of thunbergii fritillary bulb, 10g of northern adenophora root, 10g of raw dragon bone, and 10g of jujube. 14 doses, decocted in water.

[0083] Second visit: January 13, 2022. The child's snoring symptoms improved significantly, with occasional mouth breathing and mild nasal congestion. 10g of Radix Rehmanniae was added to the previous dose, and the rest of the regimen remained unchanged. Medication and nursing care remained the same as before.

[0084] Third visit: On February 3, 2022, the child's snoring had essentially disappeared, and nasal congestion had resolved. He was given another seven doses of the previous medicine to consolidate the therapeutic effect. The medication and nursing regimen remained the same as before.

[0085] 2. An 8-year-old boy was admitted to the hospital on April 15, 2025. Chief complaint: recurrent nasal congestion and snoring for six months, aggravated by throat clearing for one month. Current medical history: Six months ago, the child had recurrent nasal congestion and snoring during sleep without any obvious cause. After examination at an external hospital, he was diagnosed with "adenoid hypertrophy." He had taken montelukast and other treatments, and his symptoms were slightly relieved. One month ago, he developed fever and cough after catching a cold. He took antibiotics and Ganmao Qingre Granules, but still had nasal congestion and snoring, accompanied by throat clearing and pharyngeal discomfort. Physical examination: The pharyngeal mucosa was slightly congested, and the tonsils were II° enlarged. The nasal mucosa was slightly congested, and the middle and lower turbinates were not swollen. The tongue was red, with a greasy white coating in the middle and lower parts of the body, and a slippery pulse. Auxiliary examination: Fiberoptic nasopharyngoscopy: The posterior wall of the nasopharyngeal roof of the child's nasopharynx was exposed to a bulge of orange-striped tissue, occupying approximately 4 / 5 of the posterior nares, with congested and swollen mucosa. Western medicine diagnosis: adenoid hypertrophy. Traditional Chinese Medicine Diagnosis: Snoring; Syndrome Differentiation: Taiyang Meridian Syndrome. Treatment: Clear damp-heat in the small intestine, promote qi, unblock yang, and disperse stagnation. Prescription: Light Bamboo Leaf 10g, Raw Rehmannia Root 10g, Tongcao 6g, Poria 15g, Polyporus 10g, Alisma Orientalis 6g, stir-fried Atractylodes 10g, Cinnamon Twig 6g, Plantago 15g, Forsythia 10g, stir-fried Xanthium 6g, roasted Astragalus 15g, White Peony 10g, and Jujube 10g. 14 doses, decocted in water.

[0086] Second visit: April 29, 2025. The child's snoring and throat clearing symptoms improved significantly. Fiberoptic nasopharyngoscopy revealed a reduced size of the adenoids, now occupying approximately three-quarters of the posterior nares, and reduced mucosal congestion and swelling. The previous dose was increased with 10g of Glehnia littoralis and 15g of Codonopsis pilosula, for 14 doses. The remaining medications remained unchanged. Medication and nursing care remained the same as before.

[0087] Although the present invention has been described in detail above using general descriptions and specific embodiments, it will be apparent to those skilled in the art that modifications and improvements may be made thereto. Therefore, such modifications and improvements, without departing from the spirit of the present invention, are intended to be within the scope of protection claimed herein.

Claims

1. A Chinese medicine composition for treating adenoid hypertrophy in children, characterized in that: The traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 6-10 parts of loquat leaves, 6-10 parts of raw rehmannia root, 3-6 parts of tongcao, 6-15 parts of tuckahoe, 6-10 parts of umbellatus, 6-7 parts of oriental water chestnuts, 5-6 parts of cinnamon twigs, 6-10 parts of stir-fried atractylodes macrocephala, 10-15 parts of plantain, and 9-10 parts of jujubes.

2. The Chinese medicine composition for treating adenoids hypertrophy in children according to claim 1, characterized in that The traditional Chinese medicine composition further comprises 6 to 10 parts of salt orange seeds, 6 to 10 parts of salt lychee seeds, and 6 to 10 parts of thunbergii bulbs.

3. The Chinese medicine composition for treating adenoids hypertrophy in children according to claim 1, characterized in that The traditional Chinese medicine composition further comprises 6 to 10 portions of raw dragon bones.

4. The Chinese medicine composition for treating adenoid hypertrophy in children according to claim 1, characterized in that The traditional Chinese medicine composition further comprises 6 to 15 parts of astragalus and 6 to 10 parts of white peony root.

5. The Chinese medicine composition for treating adenoids hypertrophy in children according to claim 1, characterized in that The traditional Chinese medicine composition further comprises 9-10 parts of Forsythia suspensa and 6-10 parts of stir-fried Xanthium sibiricum fruit.

6. The Chinese medicine composition for treating adenoids hypertrophy in children according to claim 1, characterized in that: The traditional Chinese medicine composition further comprises 10 to 15 parts of Morus alba bark and 10 to 15 parts of Lepidium sativum seeds.

7. The method for preparing the Chinese medicine composition for treating adenoid hypertrophy in children according to claim 1, characterized in that: After the medicinal materials are mixed, they are soaked in water, decocted, and filtered to obtain the traditional Chinese medicine composition.

8. Use of the Chinese medicine composition according to claim 1 in preparing a medicament for treating adenoid hypertrophy in children.

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