Traditional Chinese medicine composition for treating beriberi, eczema and heat miliaria

Abstract

The invention discloses a traditional Chinese medicine composition for treating beriberi, eczema and heat miliaria, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from ginger powder, wormwood, green prickleyash, artemisia apiacea, sambucus chinensis, senecio scandens, black pepper and flos caryophylli. A broad-spectrum antifungal network is formed by the green prickleyash and the flos caryophylli, and dual inhibition is achieved on beriberi pathogenic bacteria and eczema secondary infection bacteria; artemisia argyi and artemisia apiacea are in cold-warm compatibility to regulate damp-heat toxin bidirectionally, the former warms channels, dispels cold and improves microcirculation, the latter clears heat, cools blood and inhibits inflammatory factors, sambucus chinensis can accelerate healing of an erosive surface, black pepper can expand blood capillaries to promote medicine permeation, and meanwhile, the warming, dredging and cold dispelling effects of ginger powder are improved. According to the invention, wormwood and green prickleyash are used as monarch drugs to mainly attack core pathogenesis, ginger powder and black pepper are used as ministerial drugs to enhance transdermal absorption, and cold-warm balance prevents pure heat-clearing drugs from aggravating dampness stagnation or pure warm drugs from stimulating skin.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating beriberi, eczema and prickly heat. Background Art

[0002] Athlete's foot, eczema, and heat rash are common skin diseases, closely related to hot and humid environments, microbial infections, and constitutional imbalances. Athlete's foot is often caused by dermatophyte infection, and the damp, hot, and confined foot environment provides conditions for fungal growth. The pathogenesis of eczema is complex, involving the interaction of multiple factors such as genetic susceptibility, immune disorders, and environmental stimuli, with the accumulation of damp-heat toxic pathogens in the skin as its core pathogenesis. Heat rash is caused by obstruction of sweat gland ducts, leading to sweat extravasation and superficial inflammation. It is more common in children living in hot and humid environments and those with prone to sweating. Currently, Western medicine treatments mainly use antifungal drugs, glucocorticoids, and antihistamines, but long-term use can easily lead to drug resistance and side effects such as skin atrophy. Traditional Chinese medicine preparations, while focusing on clearing heat and drying dampness, often target single symptoms and ignore the synergistic balance of cold and warm medicinal properties, resulting in limited efficacy. Most commercially available compound preparations are dominated by a single natural ingredient and lack a multi-target synergistic mechanism. They are not effective in controlling recurrent stubborn eczema or mixed infections. There is an urgent need to develop Chinese herbal compound preparations that have antibacterial, anti-inflammatory, and repair-promoting effects and can be adapted to multiple scenarios. Summary of the Invention

[0003] In view of the above situation, in order to overcome the defects of the prior art, the present invention discloses a traditional Chinese medicine composition for treating athlete's foot, eczema and prickly heat, which has antibacterial, anti-inflammatory and repair-promoting effects and is adaptable to multiple scenarios.

[0004] In order to achieve the above purpose, the following technical scheme is adopted: the present invention provides a traditional Chinese medicine composition for treating athlete's foot, eczema and prickly heat, which is prepared from a combination of ginger powder, wormwood, green pepper, Artemisia annua, comfrey, Senecio chinensis, black pepper and cloves.

[0005] Ginger powder warms the meridians and dispels cold, promotes blood circulation and dredges the collaterals, and has antibacterial and anti-inflammatory properties. It contains ingredients such as gingerol, which can promote local blood circulation, dispel cold and dampness, and relieve itchy skin. Its antibacterial properties can help inhibit fungal infections. In combination, it enhances the warming and unblocking effects, improves local microcirculation, and aids the penetration of other ingredients.

[0006] Mugwort has the benefits of dispelling dampness and relieving itching, warming the meridians and stopping bleeding, and possessing antibacterial and antiviral properties. Mugwort contains volatile oils such as eucalyptol, which inhibit various fungi and bacteria. Its warming properties can relieve itching caused by eczema and prickly heat. As one of the main ingredients in this herb, it balances cold and heat, enhancing its overall anti-inflammatory and antipruritic effects.

[0007] Green Sichuan peppercorns have antiseptic, antipruritic, cold-dispelling, and anti-inflammatory properties. They contain volatile oils like limonene and alkaloids, which significantly inhibit dermatophytes and relieve eczema redness and swelling. When used in a combination, green Sichuan peppercorns can target the core of the fungal infection, creating a synergistic antibacterial effect.

[0008] Artemisia annua has the effects of clearing heat and cooling blood, detoxifying and removing steam, and providing anti-inflammatory and antibacterial properties. Artemisinin and flavonoids inhibit skin inflammation, reducing fever and relieving itching in damp-heat-induced eczema and prickly heat. When used in a combination, Artemisia annua balances the warming properties of the formula and prevents overstimulation by the heat-inducing ingredients.

[0009] Sambucus salviae var. saponins accelerate skin repair, relieve eczema erosions, and reduce athlete's foot. Sambucus salviae var. saponins, used in combination, helps repair damaged skin barriers and reduce secondary infections.

[0010] Senecio herba has the effects of clearing heat and detoxifying, killing insects and improving eyesight, and providing antibacterial and antiviral benefits. It contains alkaloids and phenolic acids that potently inhibit common eczema pathogens, such as Staphylococcus aureus, and reduce skin exudation. When used in a composition, Senecio herba can effectively target the damp-heat toxicity that is the core of eczema and prickly heat.

[0011] Black pepper has the properties of warming the stomach, dispelling cold, promoting blood circulation and relieving pain, and providing anti-inflammatory and antibacterial benefits. Components like eugenol in black pepper essential oil dilate blood vessels, promoting drug absorption, and inhibiting fungal growth. Black pepper can be added to a drug composition to enhance transdermal absorption and overall drug efficacy.

[0012] Cloves have the benefits of warming the kidneys and promoting yang, providing antibacterial and analgesic effects, and repelling parasites and relieving itching. The eugenol contained in cloves has potent antifungal and analgesic properties, relieving itching and inflammation. When used in a composition, cloves can enhance antibacterial and analgesic effects, particularly for stubborn athlete's foot.

[0013] Furthermore, the traditional Chinese medicine composition includes the following components in parts by mass: 1-8 parts of ginger powder, 1-8 parts of mugwort, 0.1-5 parts of green pepper, 1-8 parts of artemisia annua, 0.1-5 parts of comfrey, 0.1-5 parts of Senecio chinensis, 0.1-5 parts of black pepper, and 0.1-2 parts of cloves.

[0014] Preferably, the Chinese medicine composition includes the following components in parts by mass: 1-5 parts of ginger powder, 1-5 parts of mugwort, 0.1-3 parts of green pepper, 1-5 parts of artemisia annua, 0.1-3 parts of comfrey, 0.1-3 parts of Senecio chinensis, 0.1-3 parts of black pepper, and 0.1-1.5 parts of cloves.

[0015] Preferably, the Chinese medicine composition includes the following components in parts by mass: 1-3 parts of ginger powder, 1-3 parts of mugwort, 0.1-2 parts of green pepper, 1-3 parts of artemisia annua, 0.5-2 parts of comfrey, 0.5-2 parts of Senecio chinensis, 0.5-part of black pepper, and 0.1-0.8 parts of cloves.

[0016] As the most preferred, the Chinese medicine composition includes the following components by mass: 2 parts of ginger powder, 2 parts of mugwort, 0.5 parts of green pepper, 2 parts of artemisia annua, 1 part of comfrey, 1 part of Senecio chinensis, 1 part of black pepper, and 0.5 parts of cloves.

[0017] As a further description of the above scheme, the Chinese medicine composition is used to treat athlete's foot or eczema.

[0018] As a further description of the above scheme, the Chinese medicine composition is prepared at a ratio of 85 grams to 10 kilograms of boiling water. The medicine bag is soaked in boiling water above 90 degrees for half an hour and then used for foot soaking for the treatment of athlete's foot. The water temperature for the foot soaking is 40°C.

[0019] As a further description of the above scheme, the Chinese medicine composition is prepared at a ratio of 85 grams to 80 kilograms of boiling water. The medicine bag is soaked in boiling water above 90 degrees for half an hour and then used for bathing for the treatment of eczema. The bath water temperature is 40°C.

[0020] As a further description of the above scheme, the Chinese medicine composition is prepared at a ratio of 40 grams to 2 kilograms of boiling water. The medicine bag is soaked in boiling water for half an hour and then wiped on the affected area three times a day. It can be used to treat heat rash or eczema for people who are not suitable for bathing.

[0021] The beneficial effects of the present invention are as follows: the present invention forms a broad-spectrum antifungal network through green pepper and clove, achieving dual inhibition against athlete's foot pathogens and secondary infection bacteria of eczema; mugwort and artemisia annua are combined with cold and warm properties to bidirectionally regulate damp-heat and toxic evil, the former warms the meridians and dispels cold to improve microcirculation, and the latter clears heat and cools blood to inhibit inflammatory factors, comfrey can accelerate the healing of eroded surfaces, black pepper can dilate capillaries to promote drug penetration, and at the same time enhances the warming and cold-dispersing effect of ginger powder. The present invention uses mugwort and green pepper as the main drugs to target the core pathogenesis, and ginger powder and black pepper as the auxiliary drugs to enhance transdermal absorption, and balances cold and heat to avoid pure heat-clearing drugs aggravating dampness stagnation or pure warming and hot drugs irritating the skin. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those familiar to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred embodiments and materials described herein are for illustrative purposes only and are not intended to limit the scope of this application.

[0024] The experimental methods in the following examples, unless otherwise specified, are all conventional methods, and the experimental materials used in the following examples, unless otherwise specified, are all purchased from commercial channels.

[0025] Example 1

[0026] Traditional Chinese medicine composition for treating beriberi, eczema and prickly heat

[0027] The traditional Chinese medicine composition comprises the following components in parts by mass: 1 part of ginger powder, 1 part of mugwort, 0.1 part of green pepper, 1 part of artemisia annua, 0.1 part of comfrey, 0.1 part of senecio, 0.1 part of black pepper, and 0.1 part of clove.

[0028] Example 2

[0029] Traditional Chinese medicine composition for treating beriberi, eczema and prickly heat

[0030] The traditional Chinese medicine composition comprises the following components in parts by mass: 2 parts of ginger powder, 2 parts of mugwort, 0.5 parts of green pepper, 1.5 parts of artemisia annua, 1.5 parts of comfrey, 1.5 parts of senecio, 1.5 parts of black pepper, and 1 part of clove.

[0031] Example 3

[0032] Traditional Chinese medicine composition for treating beriberi, eczema and prickly heat

[0033] The traditional Chinese medicine composition comprises the following components in parts by mass: 1.5 parts of ginger powder, 2 parts of mugwort, 1.5 parts of green pepper, 2 parts of artemisia annua, 1 part of comfrey, 1.5 parts of senecio, 1.5 parts of black pepper, and 0.3 part of cloves.

[0034] Example 4

[0035] Traditional Chinese medicine composition for treating beriberi, eczema and prickly heat

[0036] The traditional Chinese medicine composition comprises the following components in parts by mass: 2 parts of ginger powder, 2 parts of mugwort, 1.2 parts of green pepper, 1.2 parts of artemisia annua, 0.8 parts of comfrey, 1.5 parts of senecio, 1 part of black pepper, and 0.6 parts of cloves.

[0037] Example 5

[0038] Traditional Chinese medicine composition for treating beriberi, eczema and prickly heat

[0039] The Chinese medicine composition comprises the following components by weight: 2 parts of ginger powder, 2 parts of mugwort, 0.5 parts of green pepper, 2 parts of artemisia annua, 1 part of sambucus, 1 part of Senecio chinensis, 1 part of black pepper, and 0.5 parts of cloves.

[0040] Result Analysis

[0041] 300 patients were recruited, including 100 each of athlete's foot, eczema, and prickly heat, aged 18-65 years, with a disease course of ≥3 months. Those with severe liver and kidney dysfunction and allergic constitution were excluded.

[0042] The patients were divided into three groups according to the type of symptoms. Each group was randomly divided into an experimental group (50 cases) and a control group (50 cases). The experimental group used the Chinese medicine composition of the present invention (formula in Example 5), and the control group used conventional Western medicine treatment (athlete's foot: bifonazole cream; eczema: mometasone furoate cream + cetirizine hydrochloride; prickly heat: calamine lotion).

[0043] With reference to the "Guidelines for Clinical Research of New Chinese Medicines" and the EASI score for eczema, the following grading standards were developed:

[0044] Cured: Symptom score decreased by ≥95%, skin lesions completely disappeared, and there was no itching or exudation.

[0045] Markedly effective: Symptom score decreased by 70%-94%, and skin lesion area decreased by ≥60%.

[0046] Effective: Symptom score decreased by 30%-69%, and skin lesion area decreased by ≥30%.

[0047] Ineffective: Symptom score decreased by <30% or worsened.

[0048] Total effective rate = (cured + markedly effective + effective) / total number of cases × 100%.

[0049] Each experimental group was tested in the following manner:

[0050] (1) Athlete’s foot:

[0051] Before treatment: confirm the pathogen (Trichophyton rubrum, etc.) through fungal microscopy;

[0052] Treatment method: 85g medicine bag + 10L water, soak your feet at 40℃, 30min / day × 4 weeks.

[0053] Assessment period: Week 4;

[0054] Main outcome measures: Itching severity, blister / desquamation area, and fungal negative conversion rate;

[0055] (2) Eczema:

[0056] Before treatment: EASI score and VAS pruritus score were performed;

[0057] Treatment method: 85g medicine bag + 80L water, 40℃ bath, 20min / every other day × 6 weeks;

[0058] Assessment period: Week 6;

[0059] Main outcome measures: EASI score, erythema / exudate area, and recurrence rate;

[0060] (3) Heat rash:

[0061] Before treatment: measurement of skin lesion area and scoring of exudation degree;

[0062] Treatment method: 40g of liquid medicine + 2L of water, wipe, 3 times / day × 2 weeks;

[0063] Assessment period: Week 2;

[0064] Main outcome measures: number of papules, VAS score of pruritus, and skin barrier recovery time.

[0065] The above test results are shown in Table 1.

[0066] Table 1: Evaluation results of the effect of Chinese herbal composition in treating athlete's foot, eczema and prickly heat

[0067]

[0068] As can be seen from the above table, the total effective rate of the Chinese medicine composition disclosed in the present invention for beriberi is 96%, indicating that the green pepper (containing limonene) and cloves (containing eugenol) form a dual antifungal network in the composition, which has a significant inhibitory effect on pathogens such as Trichophyton rubrum, and is better than bifonazole cream (conventional antifungal drug). The total effective rate of the Chinese medicine composition disclosed in the present invention for eczema is 94%, which is attributed to the cold and warm compatibility of wormwood (cineole) and artemisia annua (artemisinin) in the composition, which inhibits inflammatory factors such as IL-6 and TNF-α, while sedge saponin accelerates the repair of erosive surface, contrasting mometasone furoate (containing hormone), reflecting its safety advantage. The total effective rate of the Chinese medicine composition disclosed in the present invention for heat rash is 96%, which is due to the fact that Senecio chinensis (containing alkaloids) can inhibit Staphylococcus aureus, black pepper promotes the dredging of sweat gland ducts, and artemisia annua cools blood and reduces temperature, which synergistically shortens the time for the rash to disappear.

[0069] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

[0070] The above description of the present invention and its embodiments is non-limiting. What is shown therein is only one embodiment of the present invention, and actual applications are not limited thereto. In short, if a person skilled in the art is inspired by this and, without departing from the purpose of the present invention, designs methods and embodiments similar to this technical solution without inventiveness, they shall fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating beriberi, eczema and prickly heat, characterized in that: Made from ginger powder, mugwort, green peppercorns, artemisia annua, elderberry, ground celery, black pepper, and cloves.

2. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 1, wherein: The invention comprises the following components in parts by weight: 1-8 parts of ginger powder, 1-8 parts of wormwood, 0.1-5 parts of green pepper, 1-8 parts of artemisia annua, 0.1-5 parts of comfrey, 0.1-5 parts of senecio, 0.1-5 parts of black pepper and 0.1-2 parts of cloves.

3. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 2, wherein: The invention comprises the following components in parts by weight: 1-5 parts of ginger powder, 1-5 parts of wormwood, 0.1-3 parts of green pepper, 1-5 parts of artemisia annua, 0.1-3 parts of comfrey, 0.1-3 parts of senecio, 0.1-3 parts of black pepper and 0.1-1.5 parts of cloves.

4. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 3, wherein: The invention comprises the following components in parts by weight: 1-3 parts of ginger powder, 1-3 parts of mugwort, 0.1-2 parts of green pepper, 1-3 parts of artemisia annua, 0.5-2 parts of comfrey, 0.5-2 parts of senecio, 0.5-part of black pepper and 0.1-0.8 parts of cloves.

5. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 4, wherein: The invention comprises the following components in parts by mass: 2 parts of ginger powder, 2 parts of mugwort, 0.5 parts of green pepper, 2 parts of artemisia annua, 1 part of comfrey, 1 part of senecio, 1 part of black pepper and 0.5 parts of cloves.

6. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to any one of claims 1 to 5, characterized in that: The traditional Chinese medicine composition is used for treating and regulating beriberi, eczema and prickly heat.

7. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 6, wherein: The Chinese medicine composition is prepared at a ratio of 85 grams to 10 kilograms of boiling water. The medicine bag is soaked in boiling water above 90 degrees Celsius for half an hour and then soaked in the feet for treating athlete's foot. The water temperature for soaking the feet is 40 degrees Celsius.

8. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 6, wherein: The Chinese medicine composition is prepared at a ratio of 85 grams to 80 kilograms of boiling water. The medicine bag is soaked in boiling water above 90 degrees for half an hour and then used for bathing. The bathing water temperature is 40 degrees Celsius for treating eczema.

9. The Chinese medicine composition for treating beriberi, eczema and prickly heat according to claim 6, wherein: The Chinese medicine composition is prepared at a ratio of 40 grams to 2 kilograms of boiling water. The medicine bag is soaked in boiling water for half an hour and then wiped on the affected area three times a day. The medicine can be used to treat heat rash or eczema for people who are not suitable for bathing.

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