Absorbable composite vertebral plate

Abstract

The invention discloses an absorbable composite vertebral plate, and relates to the technical field of medical instruments. The absorbable composite vertebral plate comprises a plurality of main bodies and two medical lines, the main bodies are made of a composite material prepared by mixing polylactic acid and non-grafted hydroxyapatite nanocrystal particles, or the main bodies are made of a composite material prepared by mixing hydroxyapatite modified polylactic acid with nanocrystal particles grafted on the surface, the main bodies are in a long strip shape, and the medical lines are arranged on the main bodies. Three rows of through holes are formed in the main body; one medical line penetrates through the through holes in the upper ends of the main bodies, the other medical line penetrates through the through holes in the lower ends of the main bodies, the main bodies are connected in series through the two medical lines in a bamboo slip mode, and the two ends of each medical line are connected to a nail rod in a spine nail rod system. According to the absorbable composite vertebral plate, the problems of stress shielding and metal debris caused by a metal vertebral plate can be avoided, CT and MRI examination are not affected, meanwhile, elements such as calcium and phosphorus are provided for bone repair, and bone repair and fusion are facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an absorbable composite vertebral plate. Background Art

[0002] In related technologies, the vertebral plates used in spinal surgery are usually made of titanium alloy. Although the elastic modulus of the spinal vertebral plates made of titanium alloy matches the vertebral bone, they have good corrosion resistance and can pass through X-rays, but they cannot be degraded in the body, which can easily cause great psychological pressure on patients. Summary of the Invention

[0003] The purpose of the present invention is to provide an absorbable composite vertebral plate to solve the problems existing in the use of existing metal vertebral plates.

[0004] To this end, an embodiment of the present invention provides an absorbable composite vertebral plate.

[0005] According to an embodiment of the present invention, the absorbable composite vertebral plate includes multiple main bodies and two medical wires. The material of the main body is a composite material prepared by mixing polylactic acid and ungrafted hydroxyapatite nanocrystal particles, or the material of the main body is a composite material prepared by mixing hydroxyapatite-modified polylactic acid with nanocrystal particles grafted on the surface. The main body is long and has three rows of through holes arranged on the main body. The diameter of the through holes is one-fifth of the width of the main body, and the spacing between adjacent through holes and between the through holes and the edges of the main body is one-half of the diameter of the through holes. One medical wire passes through the through holes on the upper ends of the multiple main bodies, and the other medical wire passes through the through holes on the lower ends of the multiple main bodies. The two medical wires connect the multiple main bodies in series in the form of bamboo slips, and the two ends of the medical wires are connected to the nail rods in the spinal nail rod system.

[0006] In some embodiments, the size of the ungrafted hydroxyapatite nanocrystalline particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystalline particles is 100-200 nm in length and 20-30 nm in width, and the mass percentage of the ungrafted hydroxyapatite nanocrystalline particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystalline particles in the composite material is 5%-20%.

[0007] In some embodiments, the host material contains less than 2% by weight of dopants.

[0008] In some embodiments, the dopant is at least one of fluorine, carbon, silicon oxide, zirconium oxide, and strontium ions.

[0009] In some embodiments, the dopant term has a grain size less than 500 nanometers.

[0010] In some embodiments, the length dimension of the main body is between 55 mm and 65 mm, the width dimension of the main body is between 6 mm and 7 mm, and the thickness dimension of the main body is between 3.5 mm and 4.0 mm.

[0011] In some embodiments, both sides of the main body are arc-shaped convex structures.

[0012] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and do not limit the present disclosure. Other features and aspects of the present disclosure will become more apparent from the following detailed description of exemplary embodiments with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the specific embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0014] Figure 1 FIG. 4 is a schematic diagram of an absorbable composite vertebral plate according to an embodiment of the present invention.

[0015] Figure 2 FIG. 4 is a schematic diagram of a main body of an absorbable composite vertebral plate according to an embodiment of the present invention.

[0016] Reference numerals:

[0017] The absorbable composite vertebral plate 100 comprises a main body 10 , a through hole 11 , and a medical thread 20 . DETAILED DESCRIPTION

[0018] The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments. However, it should be understood by those skilled in the art that the embodiments described below are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work are within the scope of protection of the present invention.

[0019] The lamina made from hydroxyapatite in this invention addresses the challenges of conventional lamina. By adjusting and controlling the material's composition and particle size, the material can achieve the desired mechanical strength. Consequently, this lamina avoids the stress shielding and metal debris issues associated with metal lamina, thus preventing CT and MRI scans. Furthermore, it provides calcium, phosphorus, and other elements for bone repair and fusion. This material can be mass-produced, effectively addressing the challenges of autologous bone.

[0020] It should be noted that hydroxyapatite, a calcium phosphate, is widely present in the human body, primarily in bones and teeth, resulting in excellent biocompatibility. Hydroxyapatite is essentially a highly interlocked ceramic calcium phosphate polymer with a calcium-to-phosphorus molar ratio of 1.67. In bones and teeth, calcium and phosphorus primarily exist as colloidal calcium phosphate crystals, forming a complex network with collagen. Hydroxyapatite binds tightly to collagen and cells, promoting bone growth and playing a key role in the connection between hard and soft tissues.

[0021] like Figure 1-Figure 2 As shown, the absorbable composite vertebral plate 100 according to an embodiment of the present invention includes a plurality of bodies 10 and two medical wires 20 .

[0022] The main body 10 is made of a composite material comprising polylactic acid (PLA) and ungrafted hydroxyapatite nanocrystal particles, or a composite material comprising hydroxyapatite-modified PLA with nanocrystal particles grafted onto its surface. The main body 10 is elongated and has three rows of through holes 11. The diameter of the through holes 11 is one-fifth of the width of the main body 10, and the spacing between adjacent through holes 11 and between a through hole 11 and the edge of the main body 10 is one-half the diameter of the through hole 11.

[0023] It can be understood that the ratio between the through hole 11 and the main body 10 is conducive to ensuring the structural strength and stability of the main body 10.

[0024] One medical line 20 passes through the through hole 11 on the upper end of the multiple main bodies 10, and another medical line 20 passes through the through hole 11 on the lower end of the multiple main bodies 10. The two medical lines 20 connect the multiple main bodies 10 in series in the form of bamboo slips, and the two ends of the medical lines 20 are connected to the nail rods in the spinal nail rod system.

[0025] In some embodiments, the size of the ungrafted hydroxyapatite nanocrystalline particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystalline particles is 100-200 nm in length and 20-30 nm in width, and the mass percentage of the ungrafted hydroxyapatite nanocrystalline particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystalline particles in the composite material is 5%-20%.

[0026] In some embodiments, the material of the main body 10 contains less than 2% by weight of dopants.

[0027] In some embodiments, the dopant is at least one of fluorine, carbon, silicon oxide, zirconium oxide, and strontium ions.

[0028] In some embodiments, the grain size of the dopant term is less than 500 nanometers.

[0029] It is understood that hydroxyapatite materials with grain sizes less than 300 nanometers can also be doped with fluorine, carbon, silicon oxide, zirconium oxide, or strontium ions with grain sizes less than 500 nanometers, all of which can enhance the hardness and strength of hydroxyapatite to varying degrees. Fluorine-doped hydroxyapatite with a small amount of F- reduces its in vivo solubility, promotes osteoblast differentiation, proliferation, and mineralization, and enhances its binding to bone tissue. Lower fluorine content results in improved stability and resistance to bone marrow resorption, but its osteoinductivity is inferior to that of HA. Strontium-doped hydroxyapatite with a small amount of Sr2+ exhibits excellent biocompatibility, bone adhesion, and osteoinductivity, enhanced in vivo degradability and bioactivity, increased bone formation, and prolonged the overall duration of new bone formation. HA containing 0.1% strontium exhibits faster surface HA deposition in Sr2+-free solutions. Adding zirconium oxide can improve mechanical properties but reduce the bioactivity of HA. Calcium fluoride can be added; the fluorine partially replaces the OH-ions in hydroxyapatite, forming fluorohydroxyapatite. This improves the thermal stability and sintering properties of the HA-ZrO2 composite, thereby enhancing the mechanical properties. The dopant can be a single component or multiple components. The total amount of the dopant in the material should be less than 2%. The grain size of the dopant should be smaller than 500 nanometers.

[0030] In some embodiments, the length of the main body 10 is between 55 mm and 65 mm, the width of the main body 10 is between 6 mm and 7 mm, and the thickness of the main body 10 is between 3.5 mm and 4.0 mm.

[0031] In some embodiments, both sides of the main body 10 are arc-shaped convex structures.

[0032] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like to indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0033] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0034] In the present invention, unless otherwise specified or limited, the terms "installed," "connected," "connect," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection, electrical connection, or communication; direct connection or indirect connection through an intermediate medium; internal communication between two elements or interaction between two elements, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0035] In the present invention, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0036] In the present invention, the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and the features of different embodiments or examples without contradiction.

[0037] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. An absorbable composite vertebral plate, characterized in that: include: A plurality of main bodies, wherein the main body material is a composite material prepared by mixing polylactic acid and ungrafted hydroxyapatite nanocrystal particles, or the main body material is a composite material prepared by mixing hydroxyapatite-modified polylactic acid with nanocrystal particles grafted on its surface, the main body being in the form of an elongated strip, and provided with through holes arranged in three columns, the diameter of the through holes being one-fifth of the width of the main body, and the spacing between adjacent through holes and between the through holes and the edge of the main body being one-half the diameter of the through holes; Two medical wires, one of which passes through the through hole on the upper ends of the multiple main bodies, and the other of which passes through the through hole on the lower ends of the multiple main bodies, connect the multiple main bodies in series in the form of bamboo slips, and both ends of the medical wires are connected to the nail rods in the spinal nail rod system.

2. The absorbable composite vertebral plate according to claim 1, characterized in that: The size of the ungrafted hydroxyapatite nanocrystal particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystal particles is 100-200nm in length and 20-30nm in width, and the mass percentage of the ungrafted hydroxyapatite nanocrystal particles or the hydroxyapatite-modified polylactic acid surface grafted nanocrystal particles in the composite material is 5%-20%.

3. The absorbable composite vertebral plate according to claim 2, characterized in that: The material of the host used contains less than 2% of dopant by total weight.

4. The absorbable composite vertebral plate according to claim 3, characterized in that: The doping item is at least one of fluorine, carbon, silicon oxide, zirconium oxide and strontium ions.

5. The absorbable composite vertebral plate according to claim 4, characterized in that: The grain size of the dopant item is less than 500 nanometers.

6. The absorbable composite vertebral plate according to claim 1, characterized in that: The length of the main body is between 55 mm and 65 mm, the width of the main body is between 6 mm and 7 mm, and the thickness of the main body is between 3.5 mm and 4.0 mm.

7. The absorbable composite vertebral plate according to claim 1, characterized in that: Both sides of the main body are arc-shaped convex structures.

Images