Impurity adsorbent for high-purity pyridine methanol and preparation method thereof

Abstract

The invention relates to the field of adsorbents for high-purity pyridine methanol, in particular to an impurity adsorbent for high-purity pyridine methanol and a preparation method of the impurity adsorbent. The impurity adsorbent for the high-purity pyridine methanol comprises a mesoporous carbon material of which the aperture is 8-12nm and the specific surface area is greater than or equal to 1500m < 2 > / g. The core material of the adsorbent is defined as mesoporous carbon with the aperture of 8-12 nm and the specific surface area larger than or equal to 1500 m < 2 > / g, and the molecular size of common impurities in pyridine methanol is within the range of 0.5-2 nm. The mesoporous carbon with the aperture of 8-12 nm not only can prevent a target product from being adsorbed through a size exclusion effect, but also can allow impurity molecules to enter pore channels. The pore diameter range can avoid desorption difficulty caused by too strong capillary force of micropores, and meanwhile, the adsorption capacity reduction caused by insufficient specific surface area of macropores is prevented. Meanwhile, the mesoporous carbon material with the optimized specific surface area provides a large number of adsorption sites, impurities containing benzene rings or conjugated structures are adsorbed through Van der Waals' force and pi-pi accumulation, and therefore the adsorption capacity is further improved.

Description

Technical Field

[0001] The present application relates to the field of adsorbents for high-purity pyridinemethanol, and in particular to an impurity adsorbent for high-purity pyridinemethanol and a preparation method thereof. Background Art

[0002] As a key pharmaceutical intermediate, pyridinemethanol is widely used in the synthesis of antiviral drugs, anticancer agents, and fine chemicals. Its purity directly impacts the safety and efficacy of the final product. As the pharmaceutical industry increases its quality requirements for APIs, pyridinemethanol purity must exceed 99.9%. However, residual impurities such as pyridinecarboxaldehyde and pyridone are structurally similar to the target product, making them difficult to remove efficiently using traditional separation techniques. The preparation of high-purity pyridinemethanol has become a bottleneck restricting the development of high-end drugs and green manufacturing.

[0003] Among existing pyridinemethanol purification technologies, adsorption has attracted considerable attention due to its ease of operation and low cost. However, conventional adsorbents generally suffer from poor selectivity and low adsorption capacity. For example, while activated carbon has a high specific surface area, its random pore structure easily adsorbs both the target product and impurities, resulting in significant yield loss of pyridinemethanol. Furthermore, the hydroxyl groups on the surface of silica gel easily form hydrogen bonds with pyridinemethanol, causing irreversible adsorption.

[0004] In response to the above-mentioned prior art, the inventors discovered that conventional adsorbents used in existing pyridinemethanol purification technologies lack selectivity, making it difficult to distinguish pyridinemethanol from structurally similar impurities. Furthermore, the adsorbent surface lacks directional functional groups, and the chemical bonding sites introduced through post-modification are unstable, prone to shedding or structural collapse after repeated regeneration. Furthermore, existing adsorbent regeneration processes often rely on high-temperature calcination or strong solvent elution, which can easily destroy the material's mesoporous structure, resulting in low reuse rates and secondary pollution. Summary of the Invention

[0005] In order to improve the above technical problems, the present application provides an impurity adsorbent for high-purity pyridinemethanol and a preparation method thereof.

[0006] In the first aspect, the present application provides a high-purity impurity adsorbent for pyridinemethanol, which adopts the following technical solution: A high-purity impurity adsorbent for pyridinemethanol, including a pore size of 8-12nm and a specific surface area of ≥1500m 2 / g of mesoporous carbon materials.

[0007] Through the above technical solution, this application defines the core material of the adsorbent as having a pore size of 8-12 nm and a specific surface area ≥1500 m 2 / g of mesoporous carbon. Since the molecular sizes of common impurities in pyridinemethanol range from 0.5 to 2 nm, the 8-12 nm pore size of mesoporous carbon can both prevent the adsorption of the target product through size exclusion while allowing impurity molecules to enter the pores. This pore size range avoids desorption difficulties caused by excessive capillary forces in micropores and prevents the reduction of adsorption capacity due to insufficient specific surface area in macropores.

[0008] At the same time, the mesoporous carbon material after optimizing the specific surface area in the present application provides a large number of adsorption sites, which adsorb impurities containing benzene rings or conjugated structures through van der Waals forces and π-π stacking, thereby further improving the adsorption capacity.

[0009] Furthermore, a molecular imprinted layer is provided on the surface of the mesoporous carbon material, and the molecular imprinted layer is made using the following technical solution: Take pyridinemethanol, pyridone, acrylic acid, 4-vinylpyridine and cross-linking agent in the molecular imprinting layer coating liquid formula, stir and mix, and place in acetonitrile, stir and mix, add mesoporous carbon material, heat and pass nitrogen to remove air, keep warm and polymerize under nitrogen atmosphere for 24 hours to prepare the molecular imprinting layer.

[0010] Through the above technical solution, this application introduces a molecularly imprinted layer (MIL) onto the mesoporous carbon surface, enhancing the adsorption selectivity of target impurities through template-cavity specific recognition. First, pyridinecarboxaldehyde is used as a template molecule to form a complex with acrylic acid through hydrogen bonding and electrostatic interactions. After cross-linking and polymerization, the template is removed to form a cavity with a complementary spatial structure. Simultaneously, the carboxyl (-COOH) and pyridine groups within the cavity can capture pyridinecarboxaldehyde and its derivatives through chemical bonding.

[0011] Furthermore, the molecular imprinting layer coating solution includes the following substances in parts by weight: 8-15 parts of pyridine carboxaldehyde; 3-5 parts of pyridone; 20-35 parts of acrylic acid; 0.1-0.5 parts of 4-vinylpyridine; 90-100 parts of cross-linking agent; 700-1000 parts of acetonitrile.

[0012] Through the above technical solution, the present application defines the formula ratio of the molecular imprinting layer coating liquid, the core of which lies in the ternary synergy of monomer-template-crosslinker: by selecting pyridine formaldehyde as the template molecule, the pyridine formaldehyde concentration after optimizing the components is moderate, which effectively improves the problem that too low pyridine formaldehyde concentration will lead to insufficient cavity density, and too high concentration will cause template aggregation, thereby reducing imprinting efficiency.

[0013] At the same time, the acrylic acid used in this application is both a functional monomer and a flexibility regulator for the cross-linked network. The acrylic acid with optimized components can balance the hardness and swelling rate of the imprinted layer.

[0014] Furthermore, the cross-linking agent includes at least one of divinylbenzene, N,N'-methylenebisacrylamide, polyethylene glycol diacrylate or ethylene glycol dimethacrylate.

[0015] Furthermore, an interface layer is provided between the molecular imprinted layer and the surface of the mesoporous carbon material, and the interface layer is an oxidized interface layer containing -COOH and -OH.

[0016] Through the above technical solution, the present application introduces an oxidized interfacial layer containing –COOH and –OH between the mesoporous carbon and the molecularly imprinted layer, enhancing interfacial compatibility through chemical anchoring. Simultaneously, nitric acid oxidation introduces carboxyl groups (-COOH) and hydroxyl groups (-OH) onto the mesoporous carbon surface, forming hydrogen and ester bonds with the acrylic acid monomer in the molecularly imprinted layer. The interfacial layer prevents the molecularly imprinted layer from peeling off during adsorption-desorption cycles, and the carboxyl groups can also adsorb positively charged impurity ions through ion exchange. After oxidation, the zeta potential of the mesoporous carbon decreases, enhancing electrostatic adsorption with positively charged impurities and further increasing the loading capacity of the imprinted layer through the interfacial layer.

[0017] In a second aspect, the present application provides a method for preparing a high-purity impurity adsorbent for pyridinemethanol, comprising the following preparation steps: The mesoporous silica is immersed in sucrose and sulfuric acid, stirred and mixed, and ultrasonically dispersed. The dispersed slurry is collected and evaporated to dryness, and then heated and dehydrated. After dehydration is completed, the carbonization treatment is carried out under a nitrogen atmosphere for 3 hours, the carbide is collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material; The mesoporous carbon material is taken and immersed in nitric acid, heated and kept under reflux, washed and dried, and then a mesoporous carbon material coated with an interface layer is prepared; The high-purity impurity adsorbent for pyridinemethanol can be prepared by coating the surface of the mesoporous carbon material coated with the interface layer with a molecular imprinting layer.

[0018] Through the above technical solution, the present application realizes material controllability by synthesizing mesoporous carbon by template method + surface functionalization. First, the present application carbonizes sucrose under sulfuric acid catalysis to fill the mesopores of the silica template. After carbonization, HF etching removes the template and retains the mesoporous structure. Secondly, the present invention introduces oxygen-containing functional groups on the carbon surface through nitric acid reflux oxidation, and at the same time partially expands the pores to improve mass transfer efficiency. Finally, the present invention uniformly coats the MIP on the mesoporous carbon surface through in-situ polymerization.

[0019] Furthermore, the carbonization treatment temperature is 850-950°C.

[0020] Furthermore, the sulfuric acid is sulfuric acid with a mass fraction of 75%.

[0021] In summary, this application has the following beneficial effects: First, this application defines the core material of the adsorbent as mesoporous carbon with a pore size of 8-12 nm and a specific surface area ≥1500 m2 / g. This is because the molecular size of common impurities in pyridinemethanol is in the range of 0.5-2 nm. The 8-12 nm pore size of mesoporous carbon can both prevent the adsorption of the target product through the size exclusion effect and allow impurity molecules to enter the pores. This pore size range can avoid the desorption difficulties caused by excessive capillary forces in micropores, while preventing the decrease in adsorption capacity due to insufficient specific surface area in macropores.

[0022] At the same time, the mesoporous carbon material after optimizing the specific surface area in the present application provides a large number of adsorption sites, which adsorb impurities containing benzene rings or conjugated structures through van der Waals forces and π-π stacking, thereby further improving the adsorption capacity.

[0023] Second, this application introduces a molecularly imprinted layer (MIL) on the mesoporous carbon surface, enhancing the adsorption selectivity of target impurities through template-cavity specific recognition. First, pyridinecarboxaldehyde is used as a template molecule, forming a complex with acrylic acid through hydrogen bonding and electrostatic interactions. After cross-linking and polymerization, the template is removed to form a cavity complementary to its spatial structure. Simultaneously, the carboxyl (-COOH) and pyridine groups within the cavity can capture pyridinecarboxaldehyde and its derivatives through chemical bonding.

[0024] Third, this application introduces an oxidized interfacial layer containing –COOH and –OH between the mesoporous carbon and the molecularly imprinted layer, enhancing interfacial compatibility through chemical anchoring. Simultaneously, nitric acid oxidation introduces carboxyl groups (-COOH) and hydroxyl groups (-OH) onto the mesoporous carbon surface, forming hydrogen and ester bonds with the acrylic acid monomers in the molecularly imprinted layer. The interfacial layer prevents the molecularly imprinted layer from peeling off during adsorption-desorption cycles, and the carboxyl groups can also adsorb positively charged impurity ions through ion exchange. Oxidation reduces the zeta potential of the mesoporous carbon, enhancing electrostatic adsorption with positively charged impurities and further increasing the loading capacity of the imprinted layer through the interfacial layer. DETAILED DESCRIPTION

[0025] The present application is further described in detail below with reference to the embodiments.

[0026] Example Example 1 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 8nm, a specific surface area of 1500m 2 / g of mesoporous carbon materials; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2:4.2, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration is completed, the product is carbonized at 850° C. for 3 hours under a nitrogen atmosphere. The carbide is collected and placed in hydrofluoric acid, immersed and washed to neutrality, and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0027] Example 2 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 10nm, a specific surface area of 1600m 2 / g of mesoporous carbon materials; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.3:4.6, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration is completed, the product is carbonized at 900° C. for 3 hours under a nitrogen atmosphere, and the carbide is collected and placed in hydrofluoric acid, immersed and washed to neutrality, and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0028] Example 3 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 12nm, a specific surface area of 1800m 2 / g of mesoporous carbon materials; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.5:5, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration is completed, the product is carbonized at 950° C. for 3 hours under a nitrogen atmosphere. The carbide is collected and placed in hydrofluoric acid, immersed and washed to neutrality, and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0029] Example 4 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 10nm, a specific surface area of 1600m 2 / g of mesoporous carbon material and a molecular imprinting layer coated on the surface of the mesoporous carbon material; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.3:4.6, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration, the carbonization treatment was carried out at 900°C for 3 hours under a nitrogen atmosphere. The carbides were collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material. 8 kg of pyridine formaldehyde, 3 kg of pyridone, 20 kg of acrylic acid, 0.1 kg of 4-vinyl pyridine, 90 kg of divinyl benzene, and 700 kg of acetonitrile were mixed and stirred to prepare a molecular imprinting layer coating solution; The mesoporous carbon is immersed in the coating liquid, polymerized at 60° C. for 24 hours under nitrogen, and then washed and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0030] Example 5 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 10nm, a specific surface area of 1600m 2 / g of mesoporous carbon material and a molecular imprinting layer coated on the surface of the mesoporous carbon material; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.3:4.6, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration, the carbonization treatment was carried out at 900°C for 3 hours under a nitrogen atmosphere. The carbides were collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material. 10 kg of pyridine formaldehyde, 4 kg of pyridone, 28 kg of acrylic acid, 0.3 kg of 4-vinyl pyridine, 95 kg of divinyl benzene, and 820 kg of acetonitrile were mixed to prepare a molecular imprinting layer coating solution; The mesoporous carbon is immersed in the coating liquid, polymerized at 60° C. for 24 hours under nitrogen, and then washed and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0031] Example 6 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 10nm, a specific surface area of 1600m 2 / g of mesoporous carbon material and a molecular imprinting layer coated on the surface of the mesoporous carbon material; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.3:4.6, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration, the carbonization treatment was carried out at 900°C for 3 hours under a nitrogen atmosphere. The carbides were collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material. 15 kg of pyridine formaldehyde, 5 kg of pyridone, 35 kg of acrylic acid, 0.5 kg of 4-vinyl pyridine, 100 kg of divinyl benzene, and 1000 kg of acetonitrile were mixed and stirred to prepare a molecular imprinting layer coating solution; The mesoporous carbon is immersed in the coating liquid, polymerized at 60° C. for 24 hours under nitrogen, and then washed and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0032] Example 7 A high-purity pyridinemethanol impurity adsorbent includes a pore size of 10nm, a specific surface area of 1600m 2 / g of mesoporous carbon material and a molecular imprinting layer coated on the surface of the mesoporous carbon material; A method for preparing an impurity adsorbent for high-purity pyridinemethanol comprises the following steps: Mesoporous silica was immersed in sucrose and 75% sulfuric acid at a mass ratio of 1:2.3:4.6, stirred and mixed, and ultrasonically dispersed at 200W for 30 minutes. The dispersed slurry was collected and evaporated to dryness at 50°C for 3 hours. After drying, it was heated to 100°C for dehydration for 2 hours. After dehydration, the carbonization treatment was carried out at 900°C for 3 hours under a nitrogen atmosphere. The carbides were collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material. The mesoporous carbon material was immersed in 65% nitric acid, heated to 80°C and then refluxed for 6 hours. After washing with deionized water, the material was dried at 50°C for 3 hours to obtain a mesoporous carbon material coated with an interface layer. 15 kg of pyridine formaldehyde, 5 kg of pyridone, 35 kg of acrylic acid, 0.5 kg of 4-vinyl pyridine, 100 kg of divinyl benzene, and 1000 kg of acetonitrile were mixed and stirred to prepare a molecular imprinting layer coating solution; The mesoporous carbon material coated with the interface layer is immersed in the coating liquid, polymerized at 60° C. for 24 hours under nitrogen, and then washed and dried to prepare a high-purity impurity adsorbent for pyridinemethanol.

[0033] Comparative Example 1 Activated carbon was selected as the adsorption material.

[0034] Performance testing 1. Adsorption capacity: Test standard: GB / T 12496.10-1999 "Wood activated carbon test method - Determination of adsorption capacity" Test conditions: Temperature: 25°C (controlled by a constant temperature water bath ±0.5°C). Pressure: atmospheric pressure (0.1 MPa).

[0035] Initial impurity concentration: 1000 ppm (target impurities such as pyridine formaldehyde and pyridone). Adsorption time: 2 hours (kinetic equilibrium verification showed adsorption equilibrium was reached within 2 hours).

[0036] Steps: Solution preparation: Accurately weigh pyridine carboxaldehyde and dissolve it in methanol to prepare a 1000 ppm impurity solution.

[0037] Adjust the pH of the solution to 7.0 (phosphate buffer).

[0038] Adsorption experiment: Add 50 mg of adsorbent to 50 mL of impurity solution and shake at 25°C (150 rpm). Samples were taken at regular intervals (0.5, 1, 1.5, and 2 hours) and the adsorbent was separated by centrifugation.

[0039] 2. Selectivity coefficient: HPLC method; competitive adsorption system: mixed solution of pyridine formaldehyde and pyridine methanol (500 ppm each); adsorption time: 2 h.

[0040] Procedure: Mixed solution preparation: Prepare a methanol solution containing 500 ppm each of pyridine formaldehyde and pyridine methanol. Adsorption experiment: Add 50 mg of adsorbent and incubate at 25°C with shaking for 2 h.

[0041] 3. Specific surface area: GB / T 19587-2017.

[0042] The test results are shown in Table 1 below: Table 1 Performance test table

[0043] From the data of Examples 1-3 and Comparative Example 1, it can be found that the present application, by selecting mesoporous carbon, can prevent the target product from being adsorbed through the size exclusion effect, while allowing impurity molecules to enter the pores. This pore size range can avoid the desorption difficulties caused by excessive capillary forces in micropores, while preventing the adsorption capacity of macropores from decreasing due to insufficient specific surface area. At the same time, the mesoporous carbon material after optimizing the specific surface area in the present application provides a large number of adsorption sites, which adsorb impurities containing benzene rings or conjugated structures through van der Waals forces and π-π stacking, thereby further improving the adsorption capacity.

[0044] Comparing Examples 1-3 with Examples 4-6 reveals that this application introduces a molecularly imprinted layer onto the mesoporous carbon surface, enhancing the adsorption selectivity of target impurities through template-cavity specific recognition. First, pyridinecarboxaldehyde is used as a template molecule, forming a complex with acrylic acid through hydrogen bonding and electrostatic interactions. After cross-linking and polymerization, the template is removed to form a cavity with a complementary spatial structure. Simultaneously, the carboxyl (-COOH) and pyridine groups within the cavity can capture pyridinecarboxaldehyde and its derivatives through chemical bonding.

[0045] Finally, by comparing Examples 4-6 with Example 7, the present invention further illustrates the introduction of an oxidized interfacial layer containing –COOH and –OH between the mesoporous carbon and the molecularly imprinted layer, enhancing interfacial compatibility through chemical anchoring. Simultaneously, nitric acid oxidation introduces carboxyl groups (-COOH) and hydroxyl groups (-OH) onto the mesoporous carbon surface, forming hydrogen and ester bonds with the acrylic acid monomer in the molecularly imprinted layer. The interfacial layer prevents the molecularly imprinted layer from peeling off during adsorption-desorption cycles, and the carboxyl groups can also adsorb positively charged impurity ions through ion exchange. After oxidation, the zeta potential of the mesoporous carbon decreases, enhancing electrostatic adsorption with positively charged impurities and further increasing the loading capacity of the imprinted layer through the interfacial layer.

[0046] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A high-purity impurity adsorbent for pyridinemethanol, characterized in that: Including pore size 8-12nm, specific surface area ≥1500m 2 / g of mesoporous carbon materials.

2. The high-purity impurity adsorbent for pyridinemethanol according to claim 1, characterized in that: The surface of the mesoporous carbon material is also provided with a molecular imprinted layer, and the molecular imprinted layer is made using the following technical solution: Take pyridinemethanol, pyridone, acrylic acid, 4-vinylpyridine and cross-linking agent in the molecular imprinting layer coating liquid formula, stir and mix, and place in acetonitrile, stir and mix, add mesoporous carbon material, heat and pass nitrogen to remove air, keep warm and polymerize under nitrogen atmosphere for 24 hours to prepare the molecular imprinting layer.

3. The impurity adsorbent for high-purity pyridinemethanol according to claim 2, characterized in that: The molecular imprinting layer coating solution includes the following substances in parts by weight: 8-15 parts of pyridine carboxaldehyde; 3-5 parts of pyridone; 20-35 parts of acrylic acid; 0.1-0.5 parts of 4-vinylpyridine; 90-100 parts of cross-linking agent; 700-1000 parts of acetonitrile.

4. The impurity adsorbent for high-purity pyridinemethanol according to claim 2, characterized in that: The cross-linking agent includes at least one of divinylbenzene, N,N'-methylenebisacrylamide, polyethylene glycol diacrylate or ethylene glycol dimethacrylate.

5. The high-purity impurity adsorbent for pyridinemethanol according to claim 2, characterized in that: An interface layer is further provided between the molecular imprinting layer and the surface of the mesoporous carbon material. The interface layer is an oxidized interface layer containing -COOH and -OH.

6. The method for preparing a high-purity impurity adsorbent for pyridinemethanol according to any one of claims 1 to 5, characterized in that: The method comprises the following preparation steps: The mesoporous silica is immersed in sucrose and sulfuric acid, stirred and mixed, and ultrasonically dispersed. The dispersed slurry is collected and evaporated to dryness, and then heated and dehydrated. After dehydration is completed, the carbonization treatment is carried out under a nitrogen atmosphere for 3 hours, the carbide is collected and placed in hydrofluoric acid, impregnated and washed to neutrality, and dried to prepare a mesoporous carbon material; The mesoporous carbon material is taken and immersed in nitric acid, heated and kept under reflux, washed and dried, and then a mesoporous carbon material coated with an interface layer is prepared; The high-purity impurity adsorbent for pyridinemethanol can be prepared by coating the surface of the mesoporous carbon material coated with the interface layer with a molecular imprinting layer.

7. The method for preparing a high-purity impurity adsorbent for pyridinemethanol according to claim 6, characterized in that: The carbonization treatment temperature is 850-950°C.

8. The method for preparing a high-purity impurity adsorbent for pyridinemethanol according to claim 6, characterized in that: The sulfuric acid is sulfuric acid with a mass fraction of 75%.

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