Traditional Chinese medicine acne-removing and inflammation-diminishing compound preparation and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine pharmacy, and particularly discloses a traditional Chinese medicine acne-removing and inflammation-diminishing compound preparation and a preparation method thereof.The traditional Chinese medicine acne-removing and inflammation-diminishing compound preparation is prepared from, by weight, 10-15 parts of rhizoma bletillae, 8-12 parts of fructus forsythiae, 10-20 parts of coix seeds, 5-10 parts of rhizoma coptidis, 8-15 parts of radix ampelopsis, 10-18 parts of honeysuckle flowers, 6-12 parts of radix sophorae flavescentis, 5-10 parts of cortex magnoliae officinalis, 8-15 parts of radix angelicae, 10-20 parts of radix polygonati officinalis and 10-15 parts of rhizoma atractylodis macrocephalae; the comprehensive acne-removing and inflammation-diminishing compound preparation is formed through scientific compatibility arrangement of various traditional Chinese medicine components, such as rhizoma bletillae, fructus forsythiae, honeysuckle flower and other medicinal materials with antibacterial and inflammation-diminishing effects and rhizoma atractylodis macrocephalae, radix polygonati officinalis and other medicinal materials with repairing and relieving effects in a synergistic combination manner; the comprehensive treatment effects of remarkably improving the antibacterial effect, promoting skin repair and reducing irritation are achieved, the extraction efficiency of active ingredients is optimized by setting an ethanol extraction and reflux process and combining a vacuum concentration technology, so that effective ingredients such as flavone and saponin are fully reserved, and the treatment effect is good. The drug effect stability and the bioavailability of the preparation are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine pharmaceutical preparations, and particularly relates to a traditional Chinese medicine acne-removing and anti-inflammatory compound preparation and a preparation method thereof. Background Art

[0002] With the in-depth study of Traditional Chinese Medicine (TCM) theory and the continuous development of modern pharmaceutical technology, TCM is increasingly being used in the treatment of dermatological diseases, demonstrating unique advantages in acne and inflammation. Through its multi-component, multi-target mechanism of action, traditional Chinese medicine can effectively intervene at various stages of acne formation, including inhibiting bacterial growth, alleviating inflammatory responses, and promoting skin repair. In recent years, TCM compound preparations have garnered widespread market attention due to their proven efficacy and minimal side effects. A wide range of TCM acne treatment products, including topical ointments, tinctures, lotions, and other dosage forms, have emerged. These preparations utilize scientifically formulated herbs with diverse properties and flavors to achieve synergistic effects and enhance therapeutic efficacy.

[0003] However, in the existing technology, although a variety of traditional Chinese medicine acne treatment products have been launched, there are still some significant deficiencies, especially in improving the comprehensive therapeutic effect of the preparations. Most products are still limited to a simple combination of a single or a few traditional Chinese medicine ingredients, and lack scientific and systematic compatibility research, resulting in difficulty in achieving an ideal balance in antibacterial effect, skin repair ability and irritation reduction. Specifically, although some products have certain antibacterial and anti-inflammatory effects, due to the single ingredients or improper compatibility, it is difficult to fully cover the multiple pathological links of acne formation, especially in promoting skin repair and reducing drug irritation to the skin. This limitation not only affects the treatment effect, but also limits the scope of application of the product and user satisfaction, so staff need to improve it. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A traditional Chinese medicine anti-acne and anti-inflammatory compound preparation is prepared from the following raw materials in parts by weight: 10-15 parts of Bletilla striata, 8-12 parts of Forsythia suspensa, 10-20 parts of Coix seeds, 5-10 parts of Coptis chinensis, 8-15 parts of Atractylodes macrocephala, 10-18 parts of Lonicera japonica, 6-12 parts of Sophora flavescens, 5-10 parts of Magnolia bark, 8-15 parts of Angelica dahurica, 10-20 parts of Polygonatum odoratum, and 10-15 parts of Atractylodes macrocephala.

[0007] Preferably, the preparation is in the form of an external ointment, tincture, or lotion.

[0008] A method for preparing a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation comprises the following steps:

[0009] S1. Weigh each raw material by weight, crush it and pass it through an 80-100 mesh sieve to obtain a mixed powder;

[0010] S2. Soak the mixed powder in 5-8 times the amount of 60-70% ethanol for 24-48 hours;

[0011] S3, heating under reflux for 2-3 times, each time for 1-2 hours, and combining the extracts;

[0012] S4, concentrating the extract under reduced pressure to an extract with a relative density of 1.10-1.20;

[0013] S5. Add pharmaceutically acceptable excipients according to dosage form requirements to prepare an external preparation.

[0014] Preferably, in step S3, the heating reflux temperature is 75-85°C.

[0015] Preferably, in step S5, the auxiliary material includes at least one of vaseline, lanolin, and glycerin.

[0016] Preferably, in step S4, the conditions for the reduced pressure concentration are: vacuum degree -0.06 to -0.08 MPa, temperature 50-60°C.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] (1) Through the scientific combination of multiple Chinese herbal ingredients, such as Bletilla striata, Forsythia suspensa, Lonicera japonica and other herbs with antibacterial and anti-inflammatory effects, and Atractylodes macrocephala, Polygonatum odoratum and other herbs with repairing and soothing effects, a comprehensive acne-removing and anti-inflammatory compound preparation is formed, thereby achieving a comprehensive therapeutic effect of significantly improving the antibacterial effect, promoting skin repair and reducing irritation, and is suitable for different types of acne and skin inflammation problems.

[0019] (2) By setting up the ethanol extraction and reflux process, combined with the vacuum concentration technology, the extraction efficiency of the active ingredients is optimized, so that the effective ingredients such as flavonoids and saponins can be fully retained, thereby achieving the effect of improving the stability of the preparation's efficacy and bioavailability, ensuring that the product can continue to exert its anti-inflammatory and acne-removing effects during use.

[0020] (3) Through the flexible configuration of different dosage forms (such as ointments, tinctures, and lotions) and the rational addition of excipients (such as vaseline, lanolin, and glycerin), the skin permeability and comfort of the preparation are enhanced, thereby achieving the effect of meeting the needs of different users. At the same time, the convenience and scope of application of the product are improved, making it easier for daily use and storage. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1It is a preparation flow chart of the present invention. DETAILED DESCRIPTION

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] Example 1:

[0024] See also Figure 1 As shown, the preparation of a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation and an external use ointment, the raw material ratio is:

[0025] Weigh the following raw materials (by weight): 12 parts of Bletilla striata, 10 parts of Forsythia suspensa, 15 parts of Coix seeds, 8 parts of Coptis chinensis, 10 parts of Atractylodes macrocephala, 15 parts of Lonicera japonica, 9 parts of Sophora flavescens, 8 parts of Magnolia bark, 12 parts of Angelica dahurica, 15 parts of Polygonatum odoratum and 12 parts of Atractylodes macrocephala.

[0026] Preparation method:

[0027] S1, crushing and mixing: crush the above raw materials separately, pass through an 80-mesh sieve, and mix evenly to obtain a mixed powder;

[0028] S2. Ethanol soaking: Place the mixed powder in an extraction tank, add 6 times the amount of 65% ethanol, and soak for 36 hours;

[0029] S3, reflux extraction: heat to 80 ° C, reflux extraction twice, each time for 1.5 hours, and combine the two extracts;

[0030] S4, vacuum concentration: the extract was concentrated under vacuum at -0.07 MPa and 55°C to obtain an extract with a relative density of 1.15;

[0031] S5. Prepare an external ointment: Take 100 g of the extract, add 150 g of vaseline, 50 g of lanolin, and 20 g of glycerin, stir evenly, and make a uniform paste. Sterilize and package the paste to obtain a traditional Chinese medicine external ointment for acne and inflammation.

[0032] Product properties: The obtained ointment is a brown semi-solid with a unique smell of traditional Chinese medicine, a uniform texture, and is easy to apply.

[0033] How to use: After cleaning the affected area, take an appropriate amount of ointment and apply it evenly on the acne or sore area, 2-3 times a day.

[0034] Example 2:

[0035] See also Figure 1As shown, a preparation of a Chinese herbal acne-removing and anti-inflammatory compound preparation and tincture, the raw material ratio is:

[0036] Weigh the following raw materials (by weight): 10 parts of Bletilla striata, 12 parts of Forsythia suspensa, 20 parts of Coix seed, 5 parts of Coptis chinensis, 15 parts of Atractylodes macrocephala, 18 parts of Lonicera japonica, 6 parts of Sophora flavescens, 10 parts of Magnolia bark, 8 parts of Angelica dahurica, 20 parts of Polygonatum odoratum and 10 parts of Atractylodes macrocephala.

[0037] Preparation method:

[0038] S1, crushing and mixing: crush the above raw materials separately, pass through a 100 mesh sieve, and mix uniformly to obtain a mixed powder;

[0039] S2. Ethanol soaking: Place the mixed powder in a sealed container, add 8 times the amount of 70% ethanol, and soak for 48 hours;

[0040] S3, reflux extraction: heat to 85 ° C, reflux extraction 3 times, each time for 1 hour, and combine the three extracts;

[0041] S4, Filtration and Concentration: The extract was coarsely filtered through a filter cloth, and then finely filtered through a 0.45 μm microporous filter membrane to obtain a clarified liquid; and concentrated under reduced pressure at a vacuum degree of -0.08 MPa and a temperature of 60°C to an extract with a relative density of 1.20;

[0042] S5. Prepare tincture: Take 50 g of the extract, add 200 mL of 95% ethanol and 150 mL of distilled water, and stir evenly; add 1 g of menthol (solubilizer), and stir until completely dissolved; adjust the pH to 6.0-7.0, filter, and dispense into brown glass bottles to obtain the tincture.

[0043] Product properties: The obtained tincture is a dark brown transparent liquid with a mixed smell of ethanol and traditional Chinese medicine, good fluidity and easy to apply.

[0044] How to use: Dip a cotton swab in an appropriate amount of tincture and apply it on acne or inflamed areas, 2-3 times a day.

[0045] Example 3:

[0046] See also Figure 1 As shown, a preparation of a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation and lotion, the raw material ratio is:

[0047] Weigh the following raw materials (by weight): 15 parts of Bletilla striata, 8 parts of Forsythia suspensa, 10 parts of Coix seed, 10 parts of Coptis chinensis, 8 parts of Atractylodes macrocephala, 10 parts of Lonicera japonica, 12 parts of Sophora flavescens, 5 parts of Magnolia bark, 15 parts of Angelica dahurica, 10 parts of Polygonatum odoratum and 15 parts of Atractylodes macrocephala.

[0048] Preparation method:

[0049] S1. Raw material pretreatment: Wash each raw material separately, dry it at 50°C until the moisture content is ≤8%, and then grind it through an 80-mesh sieve to obtain a mixed powder;

[0050] S2, water extraction process: add 10 times the amount of deionized water to the mixed powder, decoct at 100 ° C for 3 times, each time for 1 hour, combine the three decoctions, and filter with a 200 mesh filter cloth;

[0051] S3, alcohol precipitation purification: The filtrate was concentrated to 1 / 3 of the original volume, 95% ethanol was added to make the alcohol content reach 60%, and the supernatant was collected after standing at 4°C for 24 hours;

[0052] S4. Formulation: Recover ethanol from the supernatant until there is no alcohol smell, add 0.5% sodium benzoate (preservative), add 1% Tween-80 (solubilizer), adjust the pH to 5.5-6.5, add deionized water to 1000 mL, and sterilize by filtering through a 0.22 μm microporous filter membrane.

[0053] Product properties: The obtained lotion is a brown-yellow transparent liquid with a pH value of 6.0±0.5, a refreshing aroma of traditional Chinese medicine, and good fluidity.

[0054] Usage: Take 5-10mL of lotion on the palm of your hand, gently massage your face for 1-2 minutes, then rinse with clean water. Do this once in the morning and once in the evening.

[0055] Comparative Example:

[0056] Comparative Example 1 (traditional water decoction):

[0057] Ingredients: Bletilla striata, Coptis chinensis, Lonicera japonica, Sophora flavescens, and Angelica dahurica.

[0058] Preparation process: Mix the raw materials in a ratio of 1:1:1:1:1; add 10 times the amount of water and boil for 1 hour, filter; add 8 times the amount of water to the residue and boil for 0.5 hours, combine the filtrate; concentrate to 1g crude drug / mL and use it directly as an external use solution.

[0059] Comparative analysis:

[0060] Extraction of active ingredients: Examples 1 to 3 use ethanol extraction and reflux process, and the extraction rate of active ingredients such as flavonoids and saponins is increased by 40-60% compared with Comparative Example 1;

[0061] The water extraction method in Comparative Example 1 resulted in insufficient dissolution of fat-soluble components (such as berberine and matrine).

[0062] Stability: Examples 1 to 3 (containing ethanol or preservatives) can be stored for 12 months at room temperature;

[0063] The decoction of Comparative Example 1 was easily moldy and needed to be refrigerated and could only be stored for 7 days.

[0064] Skin permeability: The transdermal absorption rate of the ointment / tincture in Examples 1 and 2 is 2-3 times higher than that in Comparative Example 1;

[0065] The aqueous solution of Comparative Example 1 cannot effectively penetrate the sebum barrier.

[0066] Comparative Example 2 (Chinese medicine anti-acne powder)

[0067] Raw material composition: single Coptis chinensis powder.

[0068] Directions for use: Apply directly to the affected area with water.

[0069] Comparative analysis:

[0070] Mechanism of action: The compound prescriptions of Examples 1 to 3, through the synergistic action of "Bletilla striata-Lonicera japonica-Forsythia suspensa", have an antibacterial spectrum covering five pathogenic bacteria, including Staphylococcus aureus and Propionibacterium acnes.

[0071] Comparative Example 2 relies solely on berberine, which clinically shows to be ineffective against 30% of drug-resistant acne.

[0072] Side effects: The combination of Atractylodes macrocephala and Polygonatum odoratum in Examples 1 to 3 can reduce the skin irritation of Coptis chinensis (clinical irritation incidence <5%);

[0073] In comparative example 2, the use of Rhizoma Coptidis alone resulted in dry and scaly skin in 25% of the users.

[0074] Convenience of use: The formed preparations (creams / tinctures / lotions) of Examples 1 to 3 can be used directly;

[0075] Comparative Example 2 requires temporary preparation and the concentration is difficult to control.

[0076] Comprehensive comparison data table:

[0077]

[0078] Comparative conclusion: This application has a more comprehensive therapeutic effect than a single ingredient or simple formula (Comparative Examples 1-2) through the scientific combination of 11 herbs (such as Forsythia suspensa-Lonicera japonica to enhance antibacterial properties, and Bletilla striata-Potassium odoratum to promote repair);

[0079] The ethanol extraction combined with reflux technology (Examples 1 to 3) significantly increased the active ingredient content compared to the traditional water extraction (Comparative Example 1), and the formulation stability was better;

[0080] The molded preparation avoids the problem of uncontrollable concentration of the traditional preparation (Comparative Example 2) and reduces irritation by optimizing the excipients.

[0081] All standard parts used in the present invention can be purchased commercially, and special-shaped parts can be customized according to the description in the specification and drawings. The specific connection methods of each part adopt conventional means such as bolts, rivets, welding, etc. that are mature in the prior art. The machinery, parts and equipment all adopt conventional models in the prior art. In addition, the circuit connections adopt conventional connection methods in the prior art and will not be described in detail here. Any matters not described in detail in this specification belong to the prior art known to professionals in this field.

[0082] In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. "Multiple" means two or more, unless otherwise specifically defined.

[0083] In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "connect," "fixed," etc. should be understood broadly. For example, they may refer to fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0084] In the present invention, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0085] In the description of this specification, the reference terms "one embodiment", "some embodiments", "example", "specific example" or "some examples" mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0086] In the drawings of the embodiments disclosed in the present invention, only the structures related to the embodiments disclosed in the present invention are involved. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of the present invention can be combined with each other.

[0087] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine anti-acne and anti-inflammatory compound preparation, characterized in that: The invention comprises the following raw materials in parts by weight: 10-15 parts of bletilla striata, 8-12 parts of forsythia suspensa, 10-20 parts of coix seed, 5-10 parts of coptis chinensis, 8-15 parts of atractylodes macrocephala, 10-18 parts of honeysuckle, 6-12 parts of sophora flavescens, 5-10 parts of magnolia bark, 8-15 parts of angelica dahurica, 10-20 parts of polygonatum and 10-15 parts of atractylodes macrocephala.

2. A Chinese medicine anti-acne and anti-inflammatory compound preparation according to claim 1, characterized in that: The preparation is in the form of external ointment, tincture and lotion.

3. A method for preparing a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation, applicable to a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation according to any one of claims 1 to 2, characterized in that: The following steps are involved: S1. Weigh each raw material by weight, crush it and pass it through an 80-100 mesh sieve to obtain a mixed powder; S2. Soak the mixed powder in 5-8 times the amount of 60-70% ethanol for 24-48 hours; S3, heating under reflux for 2-3 times, each time for 1-2 hours, and combining the extracts; S4, concentrating the extract under reduced pressure to an extract with a relative density of 1.10-1.20; S5. Add pharmaceutically acceptable excipients according to dosage form requirements to prepare an external preparation.

4. The method for preparing a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation according to claim 3, characterized in that: In step S3, the heating reflux temperature is 75-85°C.

5. The method for preparing a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation according to claim 3, characterized in that: In step S5, the auxiliary material includes at least one of vaseline, lanolin, and glycerin.

6. The method for preparing a traditional Chinese medicine anti-acne and anti-inflammatory compound preparation according to claim 3, characterized in that: In step S4, the conditions for the reduced pressure concentration are: vacuum degree -0.06 to -0.08 MPa, temperature 50-60°C.

Images