Prognostic molecular markers specific for squamous and adenocarcinoma of the cervix and uses thereof

By using adenosine kinase 4 and spongiform malformation 2 protein as prognostic markers for cervical cancer, the problem of lacking specificity in assessing the prognosis of squamous cell carcinoma and adenocarcinoma of the cervical cancer in existing technologies has been solved, enabling more precise diagnosis and treatment, and improving the survival rate and quality of life of cervical cancer patients.

CN120507517BActive Publication Date: 2026-04-10ZHEJIANG CANCER HOSPITAL +1
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Patent Information

Application Number
CN202510654310.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-05-21
Publication Date
2026-04-10
Estimated Expiration
2045-05-21

AI Technical Summary

Technical Problem

The lack of biomarkers in current technologies that can specifically assess the prognosis of squamous cell carcinoma and adenocarcinoma of the cervix leads to poor diagnostic and treatment outcomes, especially since adenocarcinoma progresses rapidly and has low sensitivity to chemotherapy, resulting in poor patient prognosis.

Method used

Adenosine kinase 4 and spongiform malformation 2 protein were used as prognostic biomarkers for cervical squamous cell carcinoma and adenocarcinoma. The levels of these biomarkers were detected by methods such as ELISA, immunofluorescence analysis, and PCR. Corresponding kits or detection devices were designed to achieve accurate diagnosis and personalized treatment.

Benefits of technology

It provides novel biomarkers that can be used to assess the prognosis of cervical cancer, improving the specificity and accuracy of diagnosis, supporting the development of personalized treatment plans, and improving patient outcomes.

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Abstract

The application provides a molecular marker for evaluating the prognosis of cervical squamous cell carcinoma and adenocarcinoma and application thereof, and belongs to the technical field of biological detection. Through bioinformatics analysis methods such as multivariate statistical analysis, difference screening, single factor COX regression analysis and multi-factor COX regression analysis, the application obtains an adenine kinase 4 used for evaluating the prognosis marker of cervical squamous cell carcinoma and a brain sponge-shaped deformity 2 protein used for evaluating the prognosis biomarker of cervical adenocarcinoma. Based on the biomarkers of the application, a kit for evaluating cervical squamous cell carcinoma or adenocarcinoma is constructed, which is used for accurately evaluating the prognosis of cervical squamous cell carcinoma or adenocarcinoma.
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