Intelligent drainage tube and preparation method thereof

Abstract

The embodiment of the invention provides an intelligent drainage tube, a preparation method thereof and a drainage tube body. Wherein the drainage tube body is used for being placed in a drainage area of a receptor; a flexible electrochemical sensor module, a signal processing module and a wireless transmission module are integrated at the top of the drainage tube body; wherein the flexible electrochemical sensor module is arranged in a drainage area, and the flexible electrochemical sensor module is electrically connected with the signal processing module and the wireless transmission module in sequence; the flexible electrochemical sensor module is used for collecting one or more biological index parameters in drainage liquid in a drainage area and converting the biological index parameters into detection electric signals; the flexible electrochemical sensor module transmits one or more detection electric signals to the signal processing module; and the signal processing module amplifies one or more detection electric signals and outputs the amplified detection electric signals to the monitoring equipment through the wireless transmission module.

Description

Technical Field

[0001] The present application relates to the field of electronic technology, and in particular to an intelligent drainage tube and a preparation method thereof. Background Art

[0002] Drainage is a routine procedure after surgical procedures, used to remove fluid and gas from the surgical area, promote patient recovery, and monitor postoperative recovery. Dynamic changes in the concentration of metabolic products (such as pH, glucose, and lactate) in postoperative drainage fluid are important indicators for assessing patient recovery and early detection of complications (such as anastomotic leakage and infection).

[0003] Traditional drainage tubes are slender cylindrical and are divided into a drainage end and an extracorporeal end. The drainage end is the end that is inserted into the body, and the extracorporeal end is the part that remains outside the body and is usually connected to a drainage device. There are multiple side holes in the part of the tube body near the drainage end, and the drainage tube drains liquid through these side holes.

[0004] However, conventional drainage tubes can only drain but are unable to detect the concentration of metabolites in the drainage fluid passing through the tubes in real time. Summary of the Invention

[0005] The embodiments of the present application provide an intelligent drainage tube and a preparation method thereof, which are used to perform real-time detection of the concentration of metabolic products in the drainage fluid passing through the drainage tube.

[0006] In a first aspect, an embodiment of the present application provides a smart drainage tube, comprising:

[0007] Drainage tube body (10);

[0008] Wherein, the drainage tube body (10) is used to be placed in the drainage area of ​​the recipient;

[0009] The top of the drainage tube body (10) is integrated with a flexible electrochemical sensor module (20), a signal processing module (30), and a wireless transmission module (40);

[0010] The flexible electrochemical sensor module (20) is placed in the drainage area, and the flexible electrochemical sensor module (20) is electrically connected to the signal processing module (30) and the wireless transmission module (40) in sequence;

[0011] The flexible electrochemical sensor module (20) is used to collect one or more biological indicator parameters in the drainage fluid in the drainage area and convert them into detection electrical signals; the flexible electrochemical sensor module (20) transmits the one or more detection electrical signals to the signal processing module (30); the signal processing module (30) amplifies the one or more detection electrical signals and outputs the amplified detection electrical signals to the monitoring device through the wireless transmission module (40).

[0012] In a possible embodiment, the flexible electrochemical sensor module (20) includes one or more of a pH sensor, a glucose sensor, a lactate sensor, and a triglyceride sensor.

[0013] In one possible implementation, the signal processing module (30) includes: a voltage modulation module (31), an analog-to-digital converter (32), and a transimpedance amplifier (33):

[0014] The first end of the analog-to-digital converter (32) is electrically connected to the wireless transmission module (40), the second end of the analog-to-digital converter (32) is electrically connected to the first end of the transimpedance amplifier (33), and the second end of the transimpedance amplifier (33) is electrically connected to the flexible electrochemical sensor module (20); the first end of the voltage modulation module (31) is electrically connected to the wireless transmission module (40), and the second end of the voltage modulation module (31) is electrically connected to the flexible electrochemical sensor module (20).

[0015] In one possible embodiment, the voltage modulation module (31) includes: an AC-to-DC module (311), a low-dropout linear stabilizer (312), a waveform generator (313), a digital-to-analog converter (314), an operational amplifier (315), and a low-pass filter (316):

[0016] The first end of the AC-DC module (311) is electrically connected to the wireless transmission module (40), the second end of the AC-DC module (311) is electrically connected to the first end of the low-voltage differential linear stabilizer (312), the second end of the low-voltage differential linear stabilizer (312) is electrically connected to the first end of the waveform generator (313), the second end of the waveform generator (313) is electrically connected to the first end of the digital-to-analog converter (314), the second end of the digital-to-analog converter (314) is electrically connected to the first end of the operational amplifier (315), the second end of the operational amplifier (315) is electrically connected to the first end of the low-pass filter (316), and the second end of the low-pass filter (316) is electrically connected to the flexible electrochemical sensor module (20).

[0017] In a possible embodiment, the wireless transmission module (40) includes: a near field communication chip (42) and an antenna (41):

[0018] The first end of the near-field communication chip (42) is electrically connected to the signal processing module (30), and the second end of the near-field communication chip (42) is electrically connected to the antenna (41).

[0019] In a second aspect, an embodiment of the present application provides a method for preparing an intelligent drainage tube, comprising:

[0020] preparing a polyimide film surface of a predetermined thickness;

[0021] Based on the preset pattern, a carbon dioxide laser machine is used to induce the surface of a polyimide film of preset thickness to obtain a three-dimensional porous laser-induced graphene substrate electrode;

[0022] Preparation of flexible electrochemical sensor module based on three-dimensional porous laser-induced graphite substrate electrode;

[0023] The flexible electrochemical sensor module is attached to the top of the drainage tube body, the flexible electrochemical sensor module is connected to the signal processing module through a conductive wire, and the signal processing module is connected to the wireless transmission module through a conductive wire to obtain an intelligent drainage tube.

[0024] In one possible embodiment, a flexible electrochemical sensor module is prepared based on a three-dimensional porous laser-induced graphite substrate electrode, comprising:

[0025] A pH sensor was prepared by depositing polyaniline on the surface of a three-dimensional porous laser-induced graphite substrate electrode.

[0026] In one possible embodiment, a flexible electrochemical sensor module is prepared based on a three-dimensional porous laser-induced graphite substrate electrode, comprising:

[0027] A glucose sensor was prepared by electrodepositing platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing glucose oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0028] In one possible embodiment, a flexible electrochemical sensor module is prepared based on a three-dimensional porous laser-induced graphite substrate electrode, comprising:

[0029] A lactate sensor was prepared by electrodepositing platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing lactate oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0030] In one possible embodiment, a flexible electrochemical sensor module is prepared based on a three-dimensional porous laser-induced graphite substrate electrode, comprising:

[0031] A triglyceride sensor was prepared by electrodepositing platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing lipase, glycerol kinase and glycerol triphosphate kinase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0032] An embodiment of the present application provides an intelligent drainage tube and a preparation method thereof, wherein a flexible electrochemical sensor module, a signal processing module, and a wireless transmission module are integrated on the top of the drainage tube, wherein the flexible electrochemical sensor module can collect one or more biological indicator parameters in the drainage fluid in the drainage area to ensure smooth drainage while realizing real-time detection of the drainage fluid, and then send the one or more biological indicator parameters to the detection equipment through the signal processing module and the wireless transmission module for further analysis of the one or more biological indicator parameters. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0034] Figure 1 Schematic diagram of the structure of the intelligent drainage tube provided in the embodiment of this application Figure 1 ;

[0035] Figure 2 A schematic diagram of the principle of the intelligent drainage tube provided in an embodiment of the present application;

[0036] Figure 3 Schematic diagram of the structure of the intelligent drainage tube provided in the embodiment of this application Figure 2 ;

[0037] Figure 4 A schematic diagram of a process for preparing an intelligent drainage tube according to an embodiment of the present application;

[0038] Reference numerals:

[0039] 10- drainage tube body;

[0040] 20-Flexible electrochemical sensor module;

[0041] 30-Signal processing module;

[0042] 31- voltage modulation module;

[0043] 311-AC to DC module;

[0044] 312-Low differential pressure linear stabilizer;

[0045] 313-waveform generator;

[0046] 314-digital-to-analog converter;

[0047] 315- Operational amplifier;

[0048] 316- low-pass filter;

[0049] 32-Analog-to-digital converter;

[0050] 33-transimpedance amplifier;

[0051] 40-wireless transmission module;

[0052] 41-Near field communication chip;

[0053] 42-antenna.

[0054] The above drawings illustrate specific embodiments of the present application, which will be described in more detail below. These drawings and the textual description are not intended to limit the scope of the present application in any way, but rather to illustrate the concepts of the present application to those skilled in the art by reference to specific embodiments. DETAILED DESCRIPTION

[0055] Exemplary embodiments will be described in detail herein, with examples illustrated in the accompanying drawings. In the following description, when referring to the drawings, identical numerals in different figures represent identical or similar elements, unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present application, as detailed in the appended claims.

[0056] First, let’s explain the terms involved in this application:

[0057] An analog-to-digital converter (ADC) is an electronic device that converts analog signals into digital signals. Its operating principle is to convert continuous analog signals into discrete digital signals through four steps: sampling, holding, quantization, and encoding. Key performance indicators include resolution, conversion accuracy, and conversion speed. Common types include successive approximation, integral, and parallel comparison.

[0058] A transimpedance amplifier (TIA) is an electronic amplifier circuit that converts and amplifies current signals into voltage signals. Based on an operational amplifier, a TIA achieves current-to-voltage conversion through feedback resistors. Key performance indicators include transimpedance gain, bandwidth, and noise performance. Featuring high input impedance, low output impedance, and fast response, a TIA is commonly used in fields such as photoelectric detection, bioelectrical signal detection, and radiation detection. It can convert weak current signals generated by sensors into processable voltage signals.

[0059] AC / DC (alternating current / direct current) is a technology or device that converts alternating current (AC) into direct current (DC). Rectifiers convert AC into unidirectional, pulsating DC, which is then smoothed by filtering. Finally, voltage regulators ensure a stable DC output. There are two main types: linear and switching. The former offers stable output but low efficiency, while the latter offers high efficiency but high ripple.

[0060] A low-dropout linear regulator (LDO) is a linear voltage-regulated power supply chip consisting of a pass transistor and a reference voltage source. An error amplifier compares the output with the reference voltage and controls the conduction level of the pass transistor to stabilize the output voltage. Featuring low dropout voltage, high precision, low noise, and a simple structure, LDOs are widely used in battery-powered devices, analog circuits, RF circuits, and digital circuits, providing stable and low-noise power for various circuits.

[0061] A waveform generator (WG) is a device or circuit module that can generate a variety of specific waveform signals. Based on a clock source, it uses digital signal processing or analog circuit technology to generate waveforms. It can produce a variety of waveforms, including sine, square, triangle, sawtooth, and pulse waves. It is widely used in electronic test and measurement, communications systems, industrial control, and medical equipment, providing test, carrier, and control signals for related equipment and systems.

[0062] A digital-to-analog converter (DAC) is an electronic device that converts digital signals into analog signals. It consists of digital input registers and other components. A decoding circuit converts digital quantities into analog outputs, often using methods such as an R-2R resistor ladder. Performance indicators include resolution, conversion accuracy, and conversion speed.

[0063] An operational amplifier (OPA) is a general-purpose integrated circuit with high gain, high input impedance, and low output impedance. It operates based on a differential amplifier structure, amplifying the difference between input signals and combining negative feedback for stability. Its high gain, high input impedance, and low output impedance make it commonly used in circuits for signal amplification, calculations, and processing.

[0064] A low-pass filter (LPF) is an electronic filter that uses the impedance characteristics of components like capacitors and inductors to allow low-frequency signals to pass while attenuating or blocking high-frequency signals. Key performance indicators include cutoff frequency, passband gain, and stopband attenuation. It is commonly used in fields such as audio and image signal processing and power supply circuits to remove noise, provide anti-aliasing, and filter out ripple.

[0065] Near Field Communication (NFC) chips are integrated circuit chips based on the principle of electromagnetic induction, operating at a frequency of 13.56MHz. They support short-range wireless communication between devices and are convenient, secure, and highly compatible.

[0066] Antenna (ANT): used for receiving and transmitting wireless signals, which can enhance signal strength, improve quality and expand coverage.

[0067] Drainage is a routine procedure after surgical procedures, used to remove fluid and gas from the surgical area, promote patient recovery, and monitor postoperative recovery. Dynamic changes in the concentration of metabolic products (such as pH, glucose, and lactate) in postoperative drainage fluid are important indicators for assessing patient recovery and early detection of complications (such as anastomotic leakage and infection).

[0068] Traditional drainage tubes are slender cylindrical and are divided into a drainage end and an extracorporeal end. The drainage end is the end that is inserted into the body, and the extracorporeal end is the part that remains outside the body and is usually connected to a drainage device. There are multiple side holes in the part of the tube body near the drainage end, and the drainage tube drains liquid through these side holes.

[0069] However, conventional drainage tubes can only drain but are unable to detect the concentration of metabolites in the drainage fluid passing through the tubes in real time.

[0070] While some technologies are capable of analyzing metabolites in blood, real-time monitoring of drainage fluid remains a significant gap, particularly in the ability to accurately and continuously detect metabolic products during the drainage process. Currently, in-hospital testing of drainage fluid metabolites is almost entirely performed in large, centralized clinical laboratories. This limited coverage stems largely from the complexity and high cost of the testing technology. This method not only requires bulky, large-scale testing equipment and highly trained professionals, but also requires the extraction of fluid for testing, which poses risks of secondary contamination, delayed detection, and nosocomial infection, making it unable to meet the goal of immediate, in-situ testing.

[0071] To address the aforementioned technical issues, the inventors proposed the following technical concept: To detect metabolic products in drainage fluid in real time, they developed a method for real-time monitoring of drainage fluid during the drainage process using a conventional drainage tube. This led them to develop an improved version of the conventional drainage tube. Specifically, they fabricated a sensor made of flexible material that precisely fits the tube to detect drainage fluid without interfering with its drainage function. The sensor then wirelessly transmits the detection results to a monitoring device in real time. This improved drainage tube maintains the original drainage function of the conventional tube and can transmit the detection results to the monitoring device in real time.

[0072] The following specific embodiments describe in detail the technical solution of the present application and how the technical solution of the present application solves the above-mentioned technical problems. The following specific embodiments can be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments. The embodiments of the present application will be described below in conjunction with the accompanying drawings.

[0073] Figure 1 Schematic diagram of the structure of the intelligent drainage tube provided in the embodiment of this application Figure 1 .like Figure 1 As shown, the smart drainage tube provided in the embodiment of the present application includes:

[0074] Drainage tube body 10.

[0075] The drainage tube body 10 is designed to be placed in the drainage area of ​​a recipient. A flexible electrochemical sensor module 20, a signal processing module 30, and a wireless transmission module 40 are integrated into the top of the drainage tube body 10. The flexible electrochemical sensor module 20 is placed within the drainage area and is electrically connected to the signal processing module 30 and the wireless transmission module 40 in sequence.

[0076] The flexible electrochemical sensor module 20 is used to collect one or more biological indicator parameters in the drainage fluid in the drainage area and convert them into detection electrical signals; the flexible electrochemical sensor module 20 transmits one or more detection electrical signals to the signal processing module 30; the signal processing module 30 amplifies the one or more detection electrical signals and outputs the amplified detection electrical signals to the monitoring device through the wireless transmission module 40.

[0077] Specifically, the drainage tube 10 is made of medical-grade silicone material with good biocompatibility and flexibility. A plurality of microholes are provided on the top thereof for facilitating drainage. The sizes include but are not limited to 16-28 Fr.

[0078] The flexible electrochemical sensor module 20 is located below the micropore and is bonded to the inner wall of the drainage tube 10 through biological glue, ensuring that it is always in full contact with the drainage fluid during the flow of the liquid, and can perform metabolic product detection without interfering with continuous drainage. The flexible electrochemical sensor module 20 is electrically connected to the signal processing module 30 and the wireless transmission module 40 in turn through conductive wires. The signal processing module 30 and the wireless transmission module 40 adopt a special insulating sealing structure to ensure that the wires are isolated and protected from each other to prevent the drainage fluid from affecting the stable transmission of the electrical signal.

[0079] Figure 2 This is a schematic diagram of the principle of the intelligent drainage tube provided in the embodiment of this application. Figure 2 As shown, the principle of the intelligent drainage tube provided in the embodiment of the present application for real-time detection of drainage fluid includes:

[0080] When the drainage fluid passes through the drainage area on the inner wall of the drainage tube, the flexible electrochemical sensor module collects one or more biological indicator parameters in the drainage fluid in the drainage area, such as pH, glucose (Glucose, Glu), lactic acid (Lac), triglyceride (Tri), etc., and converts them into detection electrical signals. The flexible electrochemical sensor module transmits the one or more detection electrical signals to the signal processing module. The signal processing module amplifies the one or more detection electrical signals and outputs the amplified detection electrical signals to the monitoring device (such as a mobile phone, computer, etc.) through the wireless transmission module.

[0081] In a possible implementation, the flexible electrochemical sensor module 20 includes one or more of a pH sensor, a glucose sensor, a lactate sensor, and a triglyceride sensor.

[0082] Figure 3 Schematic diagram of the structure of the intelligent drainage tube provided in the embodiment of this application Figure 2 Among them, ECS is a flexible electrochemical sensor (ECS) module.

[0083] In one possible implementation, Figure 3 As shown, the signal processing module 30 includes: a voltage modulation module 31 , an analog-to-digital converter 32 and a transimpedance amplifier 33 .

[0084] Among them, the first end of the analog-to-digital converter 32 is electrically connected to the wireless transmission module 40, the second end of the analog-to-digital converter 32 is electrically connected to the first end of the transimpedance amplifier 33, and the second end of the transimpedance amplifier 33 is electrically connected to the flexible electrochemical sensor module 20; the first end of the voltage modulation module 31 is electrically connected to the wireless transmission module 40, and the second end of the voltage modulation module 31 is electrically connected to the flexible electrochemical sensor module 20.

[0085] Specifically, the transimpedance amplifier 33 amplifies the detection electrical signal from the flexible electrochemical sensor module 20 to obtain the amplified detection electrical signal and output it to the analog-to-digital converter 32. The analog-to-digital converter 32 converts the amplified detection electrical signal, which is an analog signal, into a digital signal and outputs it to the wireless transmission module 40.

[0086] In one possible implementation, Figure 3 As shown, the voltage modulation module 31 includes: an AC-DC converter 311 , a low-dropout linear stabilizer 312 , a waveform generator 313 , a digital-to-analog converter 314 , an operational amplifier 315 and a low-pass filter 316 .

[0087] Among them, the first end of the AC-DC module 311 is electrically connected to the wireless transmission module 40, the second end of the AC-DC module 311 is electrically connected to the first end of the low-voltage difference linear stabilizer 312, the second end of the low-voltage difference linear stabilizer 312 is electrically connected to the first end of the waveform generator 313, the second end of the waveform generator 313 is electrically connected to the first end of the digital-to-analog converter 314, the second end of the digital-to-analog converter 314 is electrically connected to the first end of the operational amplifier 315, the second end of the operational amplifier 315 is electrically connected to the first end of the low-pass filter 316, and the second end of the low-pass filter 316 is electrically connected to the flexible electrochemical sensor module 20.

[0088] Specifically, the voltage modulation module 31 modulates a preset voltage based on the electrical signal of the wireless transmission module 40 and inputs the preset voltage to the flexible electrochemical sensor module 20 , wherein the flexible electrochemical sensor module detects the drainage fluid based on the preset voltage.

[0089] In one possible implementation, Figure 3 As shown, the wireless transmission module includes a near field communication chip 41 and an antenna 42 .

[0090] A first end of the near field communication chip 41 is electrically connected to the signal processing module 30 , and a second end of the near field communication chip 41 is electrically connected to the antenna 42 .

[0091] The intelligent drainage tube provided in the embodiment of the present application integrates a flexible electrochemical sensor module, a signal processing module, and a wireless transmission module on the top of the drainage tube. The flexible electrochemical sensor module can collect one or more biological indicator parameters in the drainage fluid in the drainage area to ensure smooth drainage while realizing real-time detection of the drainage fluid. The one or more biological indicator parameters are then sent to the detection equipment through the signal processing module and the wireless transmission module, thereby realizing real-time monitoring of the drainage fluid.

[0092] Figure 4 A schematic diagram of the process for preparing the intelligent drainage tube provided in the embodiment of the present application is shown in FIG. Figure 4 As shown, the method includes:

[0093] S401, preparing a polyimide film surface with a preset thickness.

[0094] S402. Based on a preset pattern, a carbon dioxide laser machine is used to induce the surface of a polyimide film of a preset thickness to obtain a three-dimensional porous laser-induced graphene substrate electrode.

[0095] Specifically, a polyimide film surface with a preset thickness (e.g., 100 μm) is prepared, a preset pattern is input into a computer, and a CO2 laser machine is controlled by the computer to induce the polyimide film surface with the preset thickness to obtain a laser-induced graphite substrate electrode.

[0096] It is possible to divide the laser-induced graphite base electrode into a working electrode, a reference electrode and a counter electrode. The reference electrode is prepared by printing Ag / AgCl slurry on the laser-induced graphite base electrode through screen printing technology. The working electrode is the laser-induced graphite base electrode where the electrochemical reaction occurs. The reference electrode provides a stable potential reference for the entire flexible electrochemical sensor module. Its potential does not change with the composition and concentration of the drainage fluid, making the detection of the working electrode comparable and accurate. The counter electrode, the working electrode and the reference electrode together constitute a complete electrochemical circuit, allowing the current to pass smoothly in the electrolytic cell, ensuring that the electrochemical reaction on the working electrode can continue.

[0097] Possible, CO2 laser machine power 12%, scanning speed 100mm / s, scanning accuracy 200dpi.

[0098] S403. Prepare a flexible electrochemical sensor module based on a three-dimensional porous laser-induced graphite substrate electrode.

[0099] Specifically, the three-dimensional porous laser-induced graphite substrate electrode is functionally modified to form a flexible electrochemical sensor module.

[0100] In some possible embodiments, a pH sensor is prepared by depositing polyaniline on the surface of a three-dimensional porous laser-induced graphite substrate electrode.

[0101] Specifically, based on cyclic voltammetry, a pH sensor was prepared by depositing polyaniline on the surface of a three-dimensional porous laser-induced graphite substrate electrode.

[0102] Among them, the pH sensor adopts a two-electrode mode and chronopotentiometry. When the surface polyaniline comes into contact with the drainage fluid, the redox potential of the polyaniline will move with the change of pH, thereby detecting the pH change of the drainage fluid.

[0103] Possibly, the potential change can be used to calculate the pH value. The potential is linearly related to the magnitude of the potential when the pH value is 3-9, with a sensitivity of about 55.99mV lowering the potential for every 1 unit increase in pH value. In addition, after contact with liquid, a stable response can be achieved within 5 seconds.

[0104] In some possible embodiments, a glucose sensor is prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing glucose oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0105] Specifically, based on the constant potential method, a glucose sensor was prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing glucose oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0106] Among them, the glucose sensor adopts a three-electrode mode and chronoamperometry, based on the decomposition of glucose by glucose oxidase to produce the intermediate product hydrogen peroxide, and then uses metal platinum nanoparticles as a catalyst to catalyze hydrogen peroxide, and then calculates the concentration of the corresponding metabolite by measuring the content of hydrogen peroxide to detect the glucose concentration of the drainage fluid.

[0107] Possibly, the glucose sensor has a detection range up to 20 mM with a sensitivity of 0.25 uA / mM.

[0108] In some possible embodiments, a lactate sensor is prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing lactate oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0109] Specifically, based on the constant potential method, a lactate sensor was prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing lactate oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0110] Among them, the lactate sensor adopts a three-electrode mode and chronoamperometry. It decomposes lactate based on lactate oxidase to produce the intermediate product hydrogen peroxide, and then uses metal platinum nanoparticles as a catalyst to catalyze hydrogen peroxide. The concentration of the corresponding metabolite is calculated by measuring the content of hydrogen peroxide to detect the lactate concentration of the drainage fluid.

[0111] Possibly, the upper detection limit of the lactate sensor is as high as 20 μM, and its sensitivity is 0.58 μA / mM.

[0112] In some possible embodiments, a triglyceride sensor is prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode and immobilizing lipase, glycerol kinase and glycerol triphosphate kinase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0113] Specifically, based on the constant potential method, a triglyceride sensor was prepared by electrodepositing metal platinum nanoparticles on a three-dimensional porous laser-induced graphite substrate electrode, and immobilizing lipase, glycerol kinase and triphosphoglycerate kinase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

[0114] Among them, the lactate sensor adopts a three-electrode mode and chronoamperometry, based on the decomposition of triglycerides by lipase, glycerol kinase and glycerol triphosphate kinase to produce the intermediate product hydrogen peroxide, and then uses metal platinum nanoparticles as a catalyst to catalyze hydrogen peroxide. The concentration of the corresponding metabolite is calculated by measuring the content of hydrogen peroxide, thereby detecting the triglyceride concentration of the drainage fluid.

[0115] Possibly, the triglyceride sensor has a linear relationship with the current magnitude at a concentration of 0.1-10 mM.

[0116] S404, attaching the flexible electrochemical sensor module to the top of the drainage tube body, connecting the flexible electrochemical sensor module to the signal processing module through conductive wires, and connecting the signal processing module to the wireless transmission module through conductive wires to obtain an intelligent drainage tube.

[0117] The method for preparing an intelligent drainage tube provided in an embodiment of the present application induces the surface of a polyimide film of a preset thickness to obtain a three-dimensional porous laser-induced graphene laser-induced graphite base electrode, wherein the three-dimensional porous laser-induced graphene laser-induced graphite base electrode has good conductivity, chemical stability and strong biocompatibility, and is suitable for use in a living body to ensure long-term and stable monitoring effects; then, a flexible electrochemical sensor module is prepared based on the three-dimensional porous laser-induced graphite base electrode, wherein the flexible electrochemical sensor module has high detection accuracy and can simultaneously detect multiple biological indicators to achieve real-time detection of drainage fluid.

[0118] Finally, it should be noted that those skilled in the art will readily identify other embodiments of the present invention after considering the specification and practicing the invention disclosed herein. The present invention is intended to cover any variations, uses, or adaptations of the present invention that follow the general principles of the present invention and include common knowledge or customary techniques in the art not disclosed herein. The present invention is not limited to the precise structure described above and illustrated in the accompanying drawings, and various modifications and variations may be made without departing from the scope thereof. The scope of the present invention is limited solely by the appended claims.

Claims

1. An intelligent drainage tube, characterized in that: include: Drainage tube body (10); Wherein, the drainage tube body (10) is used to be placed in the drainage area of ​​a recipient; The top of the drainage tube body (10) is integrated with a flexible electrochemical sensor module (20), a signal processing module (30), and a wireless transmission module (40); The flexible electrochemical sensor module (20) is placed in the drainage area, and the flexible electrochemical sensor module (20) is electrically connected to the signal processing module (30) and the wireless transmission module (40) in sequence; The flexible electrochemical sensor module (20) is used to collect one or more biological indicator parameters in the drainage fluid in the drainage area and convert them into detection electrical signals; the flexible electrochemical sensor module (20) transmits the one or more detection electrical signals to the signal processing module (30); the signal processing module (30) amplifies the one or more detection electrical signals and outputs the amplified detection electrical signals to the monitoring device through the wireless transmission module (40).

2. The intelligent drainage tube according to claim 1, characterized in that: The flexible electrochemical sensor module (20) includes one or more of a pH sensor, a glucose sensor, a lactic acid sensor, and a triglyceride sensor.

3. The intelligent drainage tube according to claim 1, characterized in that: The signal processing module (30) includes: a voltage modulation module (31), an analog-to-digital converter (32) and a transimpedance amplifier (33): The first end of the analog-to-digital converter (32) is electrically connected to the wireless transmission module (40), the second end of the analog-to-digital converter (32) is electrically connected to the first end of the transimpedance amplifier (33), and the second end of the transimpedance amplifier (33) is electrically connected to the flexible electrochemical sensor module (20); the first end of the voltage modulation module (31) is electrically connected to the wireless transmission module (40), and the second end of the voltage modulation module (31) is electrically connected to the flexible electrochemical sensor module (20).

4. The intelligent drainage tube according to claim 3, characterized in that: The voltage modulation module (31) comprises: an AC-to-DC module (311), a low voltage difference linear stabilizer (312), a waveform generator (313), a digital-to-analog converter (314), an operational amplifier (315), and a low-pass filter (316): The first end of the AC-DC module (311) is electrically connected to the wireless transmission module (40), the second end of the AC-DC module (311) is electrically connected to the first end of the low-voltage difference linear stabilizer (312), the second end of the low-voltage difference linear stabilizer (312) is electrically connected to the first end of the waveform generator (313), the second end of the waveform generator (313) is electrically connected to the first end of the digital-to-analog converter (314), the second end of the digital-to-analog converter (314) is electrically connected to the first end of the operational amplifier (315), the second end of the operational amplifier (315) is electrically connected to the first end of the low-pass filter (316), and the second end of the low-pass filter (316) is electrically connected to the flexible electrochemical sensor module (20).

5. The intelligent drainage tube according to any one of claims 1 to 4, characterized in that: The wireless transmission module (40) includes a near field communication chip (42) and an antenna (41): Wherein, a first end of the near-field communication chip (42) is electrically connected to the signal processing module (30), and a second end of the near-field communication chip (42) is electrically connected to the antenna (41).

6. A method for preparing the intelligent drainage tube according to any one of claims 1 to 5, characterized in that: include: preparing a polyimide film surface of a predetermined thickness; Based on the preset pattern, a carbon dioxide laser machine is used to induce the surface of a polyimide film of preset thickness to obtain a three-dimensional porous laser-induced graphene substrate electrode; Preparation of a flexible electrochemical sensor module based on the three-dimensional porous laser-induced graphite substrate electrode; The flexible electrochemical sensor module is attached to the top of the drainage tube body, the flexible electrochemical sensor module is connected to the signal processing module through a conductive wire, and the signal processing module is connected to the wireless transmission module through a conductive wire to obtain an intelligent drainage tube.

7. The method according to claim 6, characterized in that The method for preparing a flexible electrochemical sensor module based on the three-dimensional porous laser-induced graphite substrate electrode comprises: The pH sensor is prepared by depositing polyaniline on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

8. The method according to claim 6, characterized in that The method for preparing a flexible electrochemical sensor module based on the three-dimensional porous laser-induced graphite substrate electrode comprises: The glucose sensor is prepared by electrodepositing metal platinum nanoparticles on the three-dimensional porous laser-induced graphite substrate electrode and immobilizing glucose oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

9. The method according to claim 6, characterized in that The method for preparing a flexible electrochemical sensor module based on the three-dimensional porous laser-induced graphite substrate electrode comprises: The lactate sensor is prepared by electro-depositing metal platinum nanoparticles on the three-dimensional porous laser-induced graphite substrate electrode and immobilizing lactate oxidase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

10. The method according to claim 6, characterized in that The method for preparing a flexible electrochemical sensor module based on the three-dimensional porous laser-induced graphite substrate electrode comprises: A triglyceride sensor is prepared by electrodepositing metal platinum nanoparticles on the three-dimensional porous laser-induced graphite substrate electrode and immobilizing lipase, glycerol kinase and glycerol triphosphate kinase on the surface of the three-dimensional porous laser-induced graphite substrate electrode.

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