Sensitive skin soothing cream and method of making same
By combining various natural ingredients, a soothing face cream is prepared that addresses the barrier dysfunction problem of sensitive skin, achieving moisturizing, antioxidant, and anti-inflammatory effects, promoting collagen production, and repairing the skin barrier.
Patent Information
- Application Number
- CN202510769668.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-10
- Publication Date
- 2026-06-30
- Estimated Expiration
- 2045-06-10
AI Technical Summary
Sensitive skin often suffers from problems such as itching, redness, and burning due to imbalances in the skin barrier caused by environmental factors, lifestyle habits, and cosmetics. Existing products are often insufficient to effectively soothe and repair these issues.
It uses ingredients such as coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, gastrodia elata extract, birch extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, and fruit acids, combined with keratin-chitosan complex gel. Through the combination of multiple active ingredients, it enhances skin moisturizing, anti-oxidation, anti-inflammation, and repairs the skin barrier.
It effectively soothes and repairs the skin barrier of sensitive skin by accelerating the metabolism of stratum corneum cells, promoting collagen production, reducing nerve and vascular reactivity, restoring the skin's moisturizing function, and reducing the penetration of external irritants.
Smart Images

Figure CN120531647B_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of cosmetic technology, specifically relating to a soothing face cream suitable for sensitive skin and its preparation method. Background Technology
[0002] Sensitive skin typically refers to skin on various parts of the body, especially facial skin, which is prone to irritation or overactivation of the immune system due to factors such as genetics, environment, cosmetics, psychological stress, and hormones. This skin type often manifests as a range of problems including itching, redness, burning, stinging, tightness, and rashes. As a physical barrier, the skin not only protects against harmful substances, irritants, and ultraviolet rays but also moisturizes, regulates inflammation, and combats aging. However, in recent years, due to environmental factors, work stress, and irregular lifestyle, diet, and sleep habits, many consumers have experienced immune system imbalances. Furthermore, improper or excessive use of skincare products containing illegal ingredients can also cause the skin to lose its proper moisturizing barrier function, leading to redness, stinging, dehydration, and tightness. These skin problems can easily cause burning and tingling sensations on the skin surface, potentially triggering severe allergic reactions. Therefore, developing a face cream that soothes redness and repairs the skin barrier, especially suitable for sensitive skin, has become a key focus of research and development in this field to help people overcome the problems caused by sensitive skin. Summary of the Invention
[0003] The purpose of this invention is to provide a soothing face cream suitable for sensitive skin and its preparation method, for soothing and repairing the skin barrier.
[0004] The objective of this invention can be achieved through the following technical solutions:
[0005] A method for preparing a soothing face cream suitable for sensitive skin, the method comprising the following steps:
[0006] S1. Take emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative and mix them evenly to obtain phase A;
[0007] S2. Take Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, and deionized water, mix them evenly, add keratin-chitosan composite gel, sonicate for 10-15 minutes, and then let stand for 10-20 hours to obtain phase B.
[0008] S3. Add phase B to phase A and homogenize at 2000-3000 rpm for 5-8 minutes to obtain the face cream.
[0009] As a preferred embodiment of the present invention, in step S1, the emulsifier includes hydrogenated lecithin and glyceryl stearate.
[0010] In a preferred embodiment of the present invention, the preservative in step S1 is octyl glycol.
[0011] In a preferred embodiment of the present invention, in step S2, the moisturizer includes lactic acid, sodium lactate, and glycerin.
[0012] As a preferred embodiment of the present invention, in step S1, the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative is 4-5:2-4:3-5:2-4:3-6:2-4:1-2:1-2:0.4-0.6:0.04-0.05.
[0013] As a preferred embodiment of the present invention, the mass ratio of hydrogenated lecithin to glyceryl stearate is 2-3:10.
[0014] As a preferred embodiment of the present invention, in step S2, the mass ratio of the Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel is 0.1-0.2:0.1-0.3:1-3:0.2-0.4:0.4-0.6:1-3:8-10:0.4-0.6:8-10:28-42:14-16.
[0015] As a preferred embodiment of the present invention, the mass ratio of lactic acid, sodium lactate and glycerol is 1:6-8:4-6.
[0016] A soothing face cream suitable for sensitive skin was prepared using the above preparation method.
[0017] The beneficial effects of this invention are:
[0018] The soothing face cream suitable for sensitive skin disclosed in this invention and its preparation method utilize the synergistic effects of coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, gastrodia elata extract, birch extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, and keratin-chitosan to achieve excellent moisturizing and antioxidant effects. It replenishes vitamins A, C, and E necessary for skin cell growth and metabolism, has anti-inflammatory and antipruritic properties, and the combined action of multiple active ingredients reduces the hyperreactivity of nerves and blood vessels, thus achieving a caring effect for sensitive skin. By accelerating the metabolism of stratum corneum cells and promoting the secretion of more new collagen in the dermis, it helps replenish lipids and restore the water-retaining function of the stratum corneum, jointly promoting the repair of the sensitive skin barrier. Attached Figure Description
[0019] The invention will now be further described with reference to the accompanying drawings.
[0020] Figure 1 These are before-and-after images of the soothing face cream suitable for sensitive skin prepared according to Example 2 of the present invention. Detailed Implementation
[0021] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0022] Preparation Example
[0023] Take silkworm silk, clean it to remove impurities, soak it in methanol to degrease it, wash it, cut it into 2cm pieces and dry it for later use.
[0024] Take 20g of a small section of silk and add it to 500mL of 0.1mol / L sodium sulfide solution. Mix and stir at 40℃ for 5h. Pass the mixture through a 200-mesh sieve, take the liquid phase and centrifuge to remove solid impurities to obtain crude keratin extract.
[0025] The crude keratin extract was dialyzed using a 10kDa dialysis bag to remove sodium sulfide impurities. The dialysis buffer was distilled water. Dialysis was performed for 72 hours, with the water changed every 8 hours to obtain the dialysis solution.
[0026] The dialysate was concentrated under vacuum at 55°C, centrifuged, and the liquid phase was taken to obtain a pure keratin solution with a concentration of 10 mg / mL.
[0027] Take 30 mL of the pure keratin solution, add 250 mg of chitosan, 6 mg of sodium tripolyphosphate and 10 mg of sodium chloride, stir well, adjust the pH to 5, let stand for 40 min, wash with water to obtain keratin-chitosan composite gel.
[0028] Example 1
[0029] A method for preparing a soothing face cream suitable for sensitive skin includes the following steps:
[0030] S1. Take emulsifier, coconut oil (Shanghai Shengyue International Trade Co., Ltd.), rapeseed oil (purchased from Shanghai Lisheng Chemical Co., Ltd.), argan oil (purchased from Jiangxi Zhonghuan Biotechnology Co., Ltd.), oat oil (purchased from Wuhan Jiangxin Biotechnology Co., Ltd.), sandalwood oil (purchased from Guangzhou Artemisia biotechnology Co., Ltd.), galangal oil (purchased from Jishui County Hongxing Natural Medicinal Fragrance Oil Factory), squalane (purchased from Shanghai Yi'en Chemical Technology Co., Ltd.), tocopheryl acetate, and preservative, mix them evenly to obtain phase A;
[0031] S2. Take Gastrodia elata extract (purchased from Guangzhou Furano Chemical Raw Materials Co., Ltd.), Chaga mushroom extract (purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.), water chestnut extract (purchased from Chengdu Pusi Biotechnology Co., Ltd.), phycocyanin (purchased from Nanjing Bermuda Biotechnology Co., Ltd.), pineapple extract (purchased from Chengdu Pusi Biotechnology Co., Ltd.), kale extract (purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.), sage extract (purchased from Shanghai Keyi Chemical Technology Co., Ltd.), fruit acid (purchased from Hebei Chuangzhiyuan Biotechnology Co., Ltd.), humectant, and deionized water, mix them evenly, add keratin-chitosan composite gel, sonicate for 10 min, and then let stand for 10 h to obtain phase B;
[0032] S3. Add phase B to phase A and homogenize at 2000 rpm for 5 minutes to obtain the face cream.
[0033] The emulsifier comprises hydrogenated lecithin and glyceryl stearate; the mass ratio of hydrogenated lecithin to glyceryl stearate is 2:10.
[0034] The preservative is caprylyl glycol.
[0035] The moisturizer comprises lactic acid, sodium lactate, and glycerin; the mass ratio of lactic acid, sodium lactate, and glycerin is 1:6:4.
[0036] The mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative is 4:2:3:2:3:2:1:1:0.4:0.04.
[0037] The mass ratio of the following ingredients is 0.1:0.1:1:0.2:0.4:1:8:0.4:8:28:14.
[0038] Example 2
[0039] A method for preparing a soothing face cream suitable for sensitive skin includes the following steps:
[0040] S1. Take emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative and mix them evenly to obtain phase A;
[0041] S2. Take Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, and deionized water, mix them evenly, add keratin-chitosan composite gel, sonicate for 12 minutes, and then let stand for 15 hours to obtain phase B.
[0042] S3. Add phase B to phase A and homogenize at 2500 rpm for 7 minutes to obtain the face cream.
[0043] The emulsifier comprises hydrogenated lecithin and glyceryl stearate; the mass ratio of hydrogenated lecithin to glyceryl stearate is 2.5:10.
[0044] The preservative is caprylyl glycol.
[0045] The moisturizer comprises lactic acid, sodium lactate, and glycerin; the mass ratio of lactic acid, sodium lactate, and glycerin is 1:7:5.
[0046] The mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative is 4.5:3:4:3:5:3:1.5:1.5:0.5:0.045.
[0047] The mass ratio of the following ingredients is 0.15:0.2:2:0.3:0.5:2:9:0.5:9:35:15.
[0048] As attached Figure 1 As shown in the figure, the test subjects washed their faces with 40°C water every day, dried them with a clean towel, and then applied the face cream of this embodiment. The before and after 12 months of this treatment showed that the test subjects' facial symptoms were significantly improved.
[0049] Example 3
[0050] A method for preparing a soothing face cream suitable for sensitive skin includes the following steps:
[0051] S1. Take emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative and mix them evenly to obtain phase A;
[0052] S2. Take Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, and deionized water, mix them evenly, add keratin-chitosan composite gel, sonicate for 15 minutes, and then let stand for 20 hours to obtain phase B.
[0053] S3. Add phase B to phase A and homogenize at 3000 rpm for 8 minutes to obtain the face cream.
[0054] The emulsifier comprises hydrogenated lecithin and glyceryl stearate; the mass ratio of hydrogenated lecithin to glyceryl stearate is 3:10.
[0055] The preservative is caprylyl glycol.
[0056] The moisturizer comprises lactic acid, sodium lactate, and glycerin; the mass ratio of lactic acid, sodium lactate, and glycerin is 1:8:6.
[0057] The mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative is 5:4:5:4:6:4:2:2:0.6:0.05.
[0058] The mass ratio of the following ingredients is 0.2:0.3:3:0.4:0.6:3:10:0.6:10:42:16.
[0059] Comparative Example 1
[0060] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:0:7:3:5:3:1.5:1.5:0.5:0.045.
[0061] Comparative Example 2
[0062] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:7:0:3:5:3:1.5:1.5:0.5:0.045.
[0063] Comparative Example 3
[0064] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:3:7:0:5:3:1.5:1.5:0.5:0.045.
[0065] Comparative Example 4
[0066] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:3:4:8:0:3:1.5:1.5:0.5:0.045.
[0067] Comparative Example 5
[0068] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:3:4:3:8:0:1.5:1.5:0.5:0.045.
[0069] Comparative Example 6
[0070] The difference from Example 2 is that the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative in phase A is 4.5:4.5:4:3:5:3:0:1.5:0.5:0.045.
[0071] Comparative Example 7
[0072] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0:0.35:2:0.3:0.5:2:9:0.5:9:35:15.
[0073] Comparative Example 8
[0074] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.35:0:2:0.3:0.5:2:9:0.5:9:35:15.
[0075] Comparative Example 9
[0076] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:0:2.3:0.5:2:9:0.5:9:35:15.
[0077] Comparative Example 10
[0078] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:2.3:0:0.5:2:9:0.5:9:35:15.
[0079] Comparative Example 11
[0080] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:2:0.8:0:2:9:0.5:9:35:15.
[0081] Comparative Example 12
[0082] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:2:0.3:2.5:0:9:0.5:9:35:15.
[0083] Comparative Example 13
[0084] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:2:0.3:0.5:11:0:0.5:9:35:15.
[0085] Comparative Example 14
[0086] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel in phase B is 0.15:0.2:2:0.3:0.5:2:9.5:0:9:35:15.
[0087] Comparative Example 15
[0088] The difference from Example 2 is that the mass ratio of Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, humectant, deionized water, and xanthan gum in phase B is 0.15:0.2:2:0.3:0.5:2:9:0.5:9:35:15.
[0089] Performance testing
[0090] Test Example 1
[0091] Human patch test
[0092] A total of 90 volunteers were selected, including 20 males and 70 females, aged 25-55 years, who met the inclusion criteria for subject volunteers. Results were recorded according to the skin reaction grading standards in the currently effective technical specifications.
[0093] Table 1 Results of the human patch test
[0094]
[0095] Table 2 Skin Reaction Grading Standards:
[0096] Rating levels Skin reaction 0 negative reaction 1 Only faint erythema 2 Erythema, infiltration, edema, and papules may be present. 3 Erythema, infiltration, edema, papules, vesicles; the reaction may extend beyond the test area. 4 Obvious erythema, severe infiltration, edema, and confluent herpes zoster; reaction extends beyond the test area.
[0097] The face cream prepared in Example 1 of this application has no adverse reaction on human skin; the inventors of this application repeated the above test using samples prepared in other examples and comparative examples, and the test results were the same as above, all showing no adverse reaction on human skin.
[0098] Test Example 2
[0099] Ninety volunteers with sensitive skin were randomly divided into 18 groups. They applied the face creams prepared in Examples 1-3 and Comparative Examples 1-15 for 30 days. The skin numerical indicators before and after treatment are shown in Table 3 below.
[0100] Table 3
[0101]
[0102]
[0103]
[0104] Test Example 3: Soothing and Repairing Efficacy Test
[0105] Ninety volunteers with sensitive skin in Test Example 2 were randomly divided into 18 groups. They applied the face creams prepared in Examples 1-3 and Comparative Examples 1-15 for 30 days. Facial images were captured using VISI A-CR before and after treatment, and the skin a* value was analyzed. The smaller the value, the milder the redness of the skin. The test results are shown in Table 4 below.
[0106] Table 4
[0107]
[0108]
[0109] The above experimental results show that the face creams prepared in Examples 1-3 of this application have good skin repair and soothing effects, which are superior to those of the comparative groups.
[0110] By adding coconut oil, rich in medium-chain fatty acids with good occlusive properties, it can form a protective film on the skin surface, reducing moisture loss. Its natural antioxidant properties help relieve skin inflammation. Rapeseed oil, rich in vitamin E and essential fatty acids, can penetrate the skin barrier, replenish lipids, repair damaged stratum corneum, and enhance skin's moisturizing ability. Argan oil, rich in vitamin E, linoleic acid, and antioxidant phenolic substances, can improve skin elasticity, reduce free radical damage, and moisturize dry and sensitive skin, relieving redness. Oat oil contains β-glucan and unsaturated fatty acids, which can promote skin wound healing, reduce capillary permeability, and reduce redness and swelling. Its anti-inflammatory properties can relieve the irritation reaction of sensitive skin. Sandalwood oil and galangal oil can reduce the hyperreactivity of nerves and blood vessels, achieving a caring effect on sensitive skin. They can inhibit histamine release, reduce skin allergy reactions, and promote blood circulation, improving skin redness. Gastrodia elata extract can inhibit nerve ending excitation, relieve skin itching and burning sensations, and regulate skin immune function, reducing sensitive reactions. Chaga mushroom extract can clear... Free radicals are eliminated, and the skin barrier function is enhanced. Water chestnut extract reduces skin inflammation and has a certain moisturizing effect. Kale extract is rich in vitamin C and other trace elements, which can promote collagen synthesis, repair damaged skin cells, and reduce free radical damage to the skin. Sage extract can regulate the above-mentioned essential oil components and prevent the accumulation of skin oil. Phycocyanin promotes skin cell metabolism and repairs the damaged barrier. Pineapple extract is rich in bromelain, which has a gentle exfoliating effect, removes aging keratinocytes, and promotes skin renewal. Fruit acid can promote the metabolism of the stratum corneum, improve rough skin, and when combined with other soothing ingredients, reduce its irritation while regulating the stratum corneum and promoting the absorption of active ingredients. A gel network constructed using keratin and chitosan can achieve a slow-release moisturizing effect, preventing the treatment effect from weakening. At the same time, keratin can mimic the natural protein structure of the skin and enhance the skin barrier, while chitosan has moisturizing, antibacterial, and wound-healing effects. The combination of the two can form a biomimetic protective film, repairing the damaged stratum corneum and reducing external irritation. Through a triple mechanism of oil replenishment, protein biomimicry, and polysaccharide moisturizing, this product repairs the sensitive skin barrier from multiple dimensions, addressing damage at three levels: stratum corneum lipids, intercellular matrix, and skin hydration, thus reducing the penetration of external irritants. Anti-inflammatory ingredients suppress the immune response, antioxidants scavenge free radicals, and nerve-soothing ingredients alleviate sensitivity symptoms. With gentle metabolism and highly effective repair, the synergistic design of these ingredients achieves both repair and soothing for sensitive skin.
[0111] The foregoing has described some embodiments of the present invention in detail, but the content described is only a preferred embodiment of the present invention and should not be considered as limiting the scope of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the patent coverage of the present invention.
Claims
1. A method for preparing a soothing face cream suitable for sensitive skin, characterized in that, The preparation method of the face cream includes the following steps: S1. Take emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative and mix them evenly to obtain phase A; S2. Take Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, and deionized water, mix them evenly, add keratin-chitosan composite gel, sonicate for 10-15 minutes, and then let stand for 10-20 hours to obtain phase B. S3. Add phase B to phase A and homogenize at 2000-3000 rpm for 5-8 minutes to obtain the face cream. The preparation method of the keratin-chitosan composite gel includes the following steps: Take silkworm silk, clean it to remove impurities, soak it in methanol to degrease it, wash it, cut it into 2cm pieces and dry it for later use. Take 20g of a small section of silk and add it to 500mL of 0.1mol / L sodium sulfide solution. Mix and stir at 40℃ for 5h. Pass the mixture through a 200-mesh sieve, take the liquid phase and centrifuge to remove solid impurities to obtain crude keratin extract. The crude keratin extract was dialyzed using a 10kDa dialysis bag to remove sodium sulfide impurities. The dialysis buffer was distilled water. Dialysis was performed for 72 hours, with the water changed every 8 hours to obtain the dialysis solution. The dialysate was concentrated under vacuum at 55°C, centrifuged, and the liquid phase was taken to obtain a pure keratin solution with a concentration of 10 mg / mL. Take 30 mL of the pure keratin solution, add 250 mg of chitosan, 6 mg of sodium tripolyphosphate and 10 mg of sodium chloride, stir well, adjust the pH to 5, let stand for 40 min, wash with water to obtain the keratin-chitosan composite gel.
2. The method for preparing a soothing face cream suitable for sensitive skin according to claim 1, characterized in that, In step S1, the emulsifier includes hydrogenated lecithin and glyceryl stearate.
3. The method for preparing a soothing face cream suitable for sensitive skin according to claim 1, characterized in that, In step S1, the preservative is octyl glycol.
4. The method for preparing a soothing face cream suitable for sensitive skin according to claim 1, characterized in that, In step S2, the moisturizer includes lactic acid, sodium lactate, and glycerin.
5. The method for preparing a soothing face cream suitable for sensitive skin according to claim 1, characterized in that, In step S1, the mass ratio of the emulsifier, coconut oil, rapeseed oil, argan oil, oat oil, sandalwood oil, galangal oil, squalane, tocopheryl acetate, and preservative is 4-5:2-4:3-5:2-4:3-6:2-4:1-2:1-2:0.4-0.6:0.04-0.
05.
6. The method for preparing a soothing face cream suitable for sensitive skin according to claim 2, characterized in that, The mass ratio of hydrogenated lecithin to glyceryl stearate is 2-3:
10.
7. The method for preparing a soothing face cream suitable for sensitive skin according to claim 1, characterized in that, In step S2, the mass ratio of the Gastrodia elata extract, Chaga mushroom extract, water chestnut extract, phycocyanin, pineapple extract, kale extract, sage extract, fruit acid, moisturizer, deionized water, and keratin-chitosan composite gel is 0.1-0.2:0.1-0.3:1-3:0.2-0.4:0.4-0.6:1-3:8-10:0.4-0.6:8-10:28-42:14-16.
8. The method for preparing a soothing face cream suitable for sensitive skin according to claim 4, characterized in that, The mass ratio of lactic acid, sodium lactate, and glycerol is 1:6-8:4-6.
9. A soothing face cream suitable for sensitive skin prepared by the preparation method according to any one of claims 1-8.
Citation Information
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