A peristaltic pump for liquid ultrafiltration and an ultrafiltration process

Abstract

The application relates to the technical field of ultrafiltration, in particular to a peristaltic pump for liquid ultrafiltration and an ultrafiltration process, which comprises a peristaltic pump body, a supporting base, a movable plate, a mounting seat, a turnover assembly, a rotating adjusting assembly and a supporting assembly. The peristaltic pump has the beneficial effects that the mounting seat is turned over by the turnover assembly, so that the curved surface of the mounting seat is away from the supporting base; then the angle between the movable plate and the supporting base is adjusted to 90 degrees by the rotating adjusting assembly; at this time, the mounting seat can be installed on the curved surface equipment through the mounting hole; the mounting seat is turned over by the turnover assembly, so that the flat surface of the mounting seat is away from the supporting base; the angle between the movable plate and the supporting base is adjusted to the inclination angle of the inclined surface equipment to be installed by the rotating adjusting assembly; the mounting seat can be installed on the inclined surface equipment through the mounting hole; the peristaltic pump body is always in the horizontal working condition; deformation of the pump body caused by installation on the curved surface / inclined surface equipment is prevented; and the radial pressure of the roller on the hose is balanced under the non-horizontal working condition.

Description

A peristaltic pump for liquid ultrafiltration and an ultrafiltration process Technical Field

[0001] This invention relates to the field of ultrafiltration technology, specifically to a peristaltic pump for liquid ultrafiltration and an ultrafiltration process. Background Technology

[0002] In the production of shingles virus vaccines, the virus culture medium needs to be concentrated and purified by a tangential flow ultrafiltration system. This process requires maintaining biological activity (activity retention rate ≥95%) and ensuring an absolutely sterile environment. Existing ultrafiltration devices often need to be installed on the side wall of biosafety cabinets or fermenters.

[0003] However, peristaltic pumps need to be installed on non-standard mounting surfaces (inclination ≤15° or curvature radius ≥200mm) on the side walls of biosafety cabinets and fermenters. Standard bases cannot fit curved / inclined equipment (such as the 12° inclination angle of the baffle plate in the biosafety cabinet). Forced installation causes the pump body to deform by 0.5°-1.2°. Under non-horizontal conditions, the radial pressure of the rollers on the hose is uneven, resulting in instantaneous flow fluctuations exceeding ±6% (ultrafiltration process requires ≤±2%), which directly affects the integrity of the virus envelope and leads to a decrease in biological activity.

[0004] Therefore, it is necessary to provide a peristaltic pump for liquid ultrafiltration and an ultrafiltration process to solve the above problems.

[0005] It should be noted that the information disclosed in this background section is only for understanding the background technology of this application concept, and therefore may include information that does not constitute prior art. Summary of the Invention

[0006] Based on the aforementioned problems in the existing technology, the problem to be solved by this application is to provide a peristaltic pump and ultrafiltration process for liquid ultrafiltration, so as to achieve the effect of fitting curved / sloping surfaces.

[0007] The technical solution adopted by this application to solve its technical problem is: a peristaltic pump for liquid ultrafiltration, comprising:

[0008] Peristaltic pump body;

[0009] The support base is fixed to the bottom of the peristaltic pump body;

[0010] The movable plate is provided in two sets, which are rotatably mounted on both sides of the support base;

[0011] The mounting base is located between two sets of movable plates, with one side being a flat surface and the other side being a curved surface. The mounting base has multiple sets of mounting holes for mounting on inclined or curved surfaces, and the mounting base is also equipped with a handle.

[0012] A flip-up assembly, located within the movable plate, is used to flip the mounting base.

[0013] The rotation adjustment component, located inside the movable plate, is used to adjust the angle between the movable plate and the support base;

[0014] A support assembly, positioned between the movable plate and the support base, is used to support the support base.

[0015] Preferably, the flipping component includes an adjustment groove, which is opened on the side of the movable plate near the mounting base. An adjustment block is slidably disposed in the adjustment groove. A rotating groove is opened on the side of the adjustment block near the mounting base. A second rotating shaft is disposed at the position of the corresponding rotating groove on the mounting base. The second rotating shaft is disposed in the adjustment groove.

[0016] The flip assembly also includes a positioning element for limiting the position of the flipped mounting base.

[0017] Preferably, the adjusting block is provided with a first limiting groove that passes through the adjusting block, and the second rotating shaft is provided with a second limiting groove at the position corresponding to the first limiting groove. A limiting post is provided at the top of the adjusting groove at the position corresponding to the first limiting groove. The limiting post passes through the first limiting groove and the second limiting groove. When the adjusting block is at the bottom of the adjusting groove, the limiting post separates from the second limiting groove.

[0018] Preferably, a locking block top groove is provided on the side of the adjusting block away from the mounting base. When the adjusting block is located at the top or bottom of the adjusting groove, a locking slot is provided at the corresponding position of the locking block top groove of the adjusting groove. The locking slot has a frustum-shaped structure. A locking block is slidably disposed in the locking block top groove. The end of the locking block near the locking slot has a frustum-shaped structure. A first spring is connected between the locking block and the locking block top groove to push the locking block into the locking slot.

[0019] Preferably, the positioning component includes a first positioning groove, which is located on the side of the mounting base away from the support base. A positioning post is provided on the mounting base at the position corresponding to the first positioning groove. A first stop top groove is provided in the movable plate, which communicates with the first positioning groove. A first stop block is slidably provided in the first stop top groove. A third spring is connected between the first stop block and the first stop top groove to push the first stop block into the first positioning groove.

[0020] Both the first positioning groove and the positioning post are arc-shaped structures, and the center of the first positioning groove and the positioning post coincides with the center of the second rotating shaft. The first stop block has a first stop inclined surface on the side away from the support base.

[0021] Preferably, the positioning component further includes a second positioning groove, which is located at the bottom of the movable plate. A second stop top groove is provided inside the movable plate, and the second stop top groove communicates with the second positioning groove. A second stop block is slidably disposed inside the second stop top groove. A fourth spring is connected between the second stop top groove and the second stop block to push the second stop block into the second positioning groove. A second stop inclined surface is provided at the bottom of the second stop block.

[0022] Preferably, the rotation adjustment component includes an adjustment through hole, which is opened on the movable plate. A first rotating shaft is provided at the position of the adjustment through hole on the support base. The first rotating shaft is rotatably disposed in the adjustment through hole. A limit groove is opened in the movable plate, and the limit groove communicates with the adjustment through hole.

[0023] A rotation limiting groove is provided on the circumference of the first rotating shaft at the position of the corresponding limiting groove. A limiting slider is slidably arranged in the limiting groove. A rotation limiting block is provided at the position of the limiting slider at the corresponding rotation limiting groove. A second spring is connected between the limiting slider and the limiting groove to push the limiting groove to move toward the first rotating shaft.

[0024] Preferably, the top of the movable plate is provided with a pressing groove, which is connected to the limiting slide groove. A pressing block is slidably arranged in the pressing groove. A pressing slope is provided at the bottom of the pressing block. A supporting groove is provided on the limiting slide block, which passes through the limiting slide block. A guide groove is provided on one side of the pressing groove. A guide block is provided at the position of the pressing block corresponding to the guide groove. The guide block is slidably arranged in the guide groove.

[0025] A traction groove is provided on the side of the pressing block away from the guide block. A traction rope is connected in the traction groove. Two branch ropes are provided at the other end of the traction rope. Each branch rope passes through the bottom of the first gear top groove and the second gear top groove and is connected to the first gear block and the second gear block respectively.

[0026] Preferably, the support assembly includes a support block, which is disposed on both sides of the support base. The bottom of the support block has multiple sets of support slots. The movable plate has a storage slot on the side near the support block. A support plate is rotatably disposed on the top of the storage slot. The support plate is used to extend into the support slot. A through hole is provided in the support slot. The through hole passes through the support block, the support base, and the support plate. When the support plate extends into the support slot, it is fixed by a support pin passing through the support plate.

[0027] A liquid ultrafiltration process is also proposed, which is carried out using the above-mentioned apparatus, and the process includes:

[0028] Pretreatment stage: Cell debris and large particulate impurities are removed by deep filtration while retaining virus particles. Buffer is added quantitatively using a multi-channel peristaltic pump to ensure the stability of subsequent ultrafiltration.

[0029] Tangential flow ultrafiltration: It adopts hollow fiber membrane, and drives the ultrafiltration loop to circulate through a high-flow peristaltic pump linked with a transmembrane pressure sensor, and dynamically adjusts the speed.

[0030] Dialysis replacement: The fluid replenishment and drainage are controlled separately through a dual-pump linkage system, and the fluid replenishment rate = drainage rate ±% tolerance.

[0031] Stabilizer addition: The stabilizer is added via a micro-peristaltic pump.

[0032] The beneficial effects of this application are as follows: This application provides a peristaltic pump and ultrafiltration process for liquid ultrafiltration. By flipping the mounting base with a flipping component, the curved surface of the mounting base is moved away from the support base. Then, by rotating the adjusting component, the angle between the movable plate and the support base is adjusted to 90 degrees. At this time, the mounting base can be installed on the curved surface device through the mounting hole, and the support component supports the support base. The peristaltic pump body is placed horizontally. By flipping the mounting base with a flipping component, the plane of the mounting base is moved away from the support base. At this time, by rotating the adjusting component, the angle between the movable plate and the support base is adjusted to the tilt angle of the inclined surface device to be installed. The peristaltic pump body is placed horizontally, and the support component supports the support base, thus allowing it to be installed close to the curved / inclined surface device. This ensures that the peristaltic pump body is always in a horizontal working condition, preventing deformation of the pump body during installation on the curved / inclined surface device, preventing uneven radial pressure of the roller on the hose under non-horizontal working conditions, ensuring stable instantaneous flow fluctuations, and thus ensuring the integrity of the virus envelope and preventing a decrease in biological activity.

[0033] In addition to the purposes, features, and advantages described above, this application has other purposes, features, and advantages. A further detailed description of this application will be provided below with reference to the figures. Attached Figure Description

[0034] Figure 1 is a three-dimensional structural schematic diagram of the present invention;

[0035] Figure 2 is a cross-sectional structural diagram of the present invention;

[0036] Figure 3 is an enlarged schematic diagram of the structure at point A in Figure 2;

[0037] Figure 4 is a cross-sectional view of the supporting connecting block and movable plate of the present invention;

[0038] Figure 5 is an enlarged schematic diagram of the structure at point B in Figure 4;

[0039] Figure 6 is a cross-sectional view of the movable plate of the present invention;

[0040] Figure 7 is an enlarged schematic diagram of the structure at point C in Figure 6;

[0041] Figure 8 is an enlarged schematic diagram of the structure at point D in Figure 6;

[0042] Figure 9 is a three-dimensional structural schematic diagram of the mounting base of the present invention;

[0043] Figure 10 is a three-dimensional structural diagram of the first rotating shaft, pressing block and limiting slider of the present invention.

[0044] In the diagram: 1. Peristaltic pump body; 2. Support base; 3. Mounting seat; 4. Mounting hole; 5. Handle; 6. Support connecting block; 7. Through hole; 8. Support plate; 9. Movable plate; 10. First rotating shaft; 11. Pressing block; 12. First positioning groove; 13. Adjusting groove; 14. Limiting post; 15. Adjusting block; 1501. First limiting groove; 1502. Rotating groove; 16. Second rotating shaft; 1601. Second limiting groove; 17. Locking groove; 18. Locking block; 19. Locking block top groove; 20. First spring; 21. Second positioning groove; 22. Support locking groove; 23. 24. Support pin; 25. Storage slot; 26. Positioning post; 27. First stop block; 28. First stop inclined surface; 29. ​​Adjustment through hole; 20. Rotation limit groove; 31. Limiting slide groove; 32. Second spring; 33. Limiting slider; 34. Support groove; 35. Rotation limit block; 36. Guide groove; 37. Guide block; 38. Traction groove; 39. Pressing groove; 40. Traction rope; 41. First stop top groove; 42. Third spring; 43. Second stop top groove; 44. Fourth spring; 45. Second stop block; 46. Second stop inclined surface. Detailed Implementation

[0045] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0046] As shown in Figures 1-10, this application provides a peristaltic pump for liquid ultrafiltration, comprising: a peristaltic pump body 1; a support base 2 fixed to the bottom of the peristaltic pump body 1; two sets of movable plates 9 rotatably disposed on both sides of the support base 2; a mounting seat 3 disposed between the two sets of movable plates 9, with one side being a flat surface and the other side being a curved surface, the mounting seat 3 having multiple sets of mounting holes 4 for mounting on an inclined surface or a curved surface, and the mounting seat 3 also having a handle 5; a flipping assembly disposed within the movable plates 9 for flipping the mounting seat 3; a rotation adjustment assembly disposed within the movable plates 9 for adjusting the angle between the movable plates 9 and the support base 2; and a support assembly disposed between the movable plates 9 and the support base 2 for supporting the support base 2.

[0047] By flipping the mounting base 3 with the flipping component, the curved surface of the mounting base 3 is moved away from the support base 2. Then, by rotating the adjustment component, the angle between the movable plate 9 and the support base 2 is adjusted to 90 degrees. At this time, the mounting base 3 can be installed on the curved surface device through the mounting hole 4, and the support base 2 is supported by the support component. At this time, the peristaltic pump body 1 is placed horizontally. By flipping the mounting base 3 with the flipping component, the flat surface of the mounting base 3 is moved away from the support base 2. At this time, by rotating the adjustment component, the angle between the movable plate 9 and the support base 2 is adjusted to the tilt angle of the inclined surface device to be installed. At this time, the peristaltic pump body 1 is placed horizontally, and the support base 2 is supported by the support component. This allows it to be installed close to the curved / inclined surface device, ensuring that the peristaltic pump body 1 is always in a horizontal working condition. This prevents the pump body from deforming when installed on the curved / inclined surface device, prevents uneven radial pressure of the roller on the hose under non-horizontal working conditions, ensures stable instantaneous flow fluctuations, and thus ensures the integrity of the virus envelope and prevents a decrease in biological activity.

[0048] Specifically, as shown in Figures 2-3, the flipping assembly includes an adjustment groove 13, which is located on the side of the movable plate 9 near the mounting base 3. An adjustment block 15 is slidably disposed in the adjustment groove 13. A rotating groove 1502 is provided on the side of the adjustment block 15 near the mounting base 3. A second rotating shaft 16 is provided at the position of the corresponding rotating groove 1502 on the mounting base 3, and the second rotating shaft 16 is located in the adjustment groove 13. The flipping assembly also includes a positioning component for limiting the position of the flipped mounting base 3.

[0049] Mounting base 3 can drive adjusting block 15 to slide within adjusting groove 13 via second rotating shaft 16.

[0050] Specifically, as shown in Figure 3, the adjusting block 15 is provided with a first limiting groove 1501, which passes through the adjusting block 15. The second rotating shaft 16 is provided with a second limiting groove 1601 at the position corresponding to the first limiting groove 1501. A limiting post 14 is provided at the top of the adjusting groove 13 at the position corresponding to the first limiting groove 1501. The limiting post 14 passes through the first limiting groove 1501 and the second limiting groove 1601. When the adjusting block 15 is at the bottom of the adjusting groove 13, the limiting post 14 separates from the second limiting groove 1601.

[0051] The limiting post 14 limits the rotation of the second rotating shaft 16. When the adjusting block 15 slides to the bottom of the adjusting groove 13, the limiting post 14 separates from the second rotating shaft 16, and the rotation limitation on the second rotating shaft 16 is canceled. At this time, the mounting base 3 can be flipped over.

[0052] Specifically, as shown in Figure 3, the adjusting block 15 has a locking block top groove 19 on the side away from the mounting base 3. When the adjusting block 15 is located at the top or bottom of the adjusting groove 13, a locking groove 17 is provided at the corresponding position of the locking block top groove 19 in the adjusting groove 13. The locking groove 17 has a frustum-shaped structure. A locking block 18 is slidably disposed in the locking block top groove 19. The end of the locking block 18 near the locking groove 17 has a frustum-shaped structure. A first spring 20 is connected between the locking block 18 and the locking block top groove 19 to push the locking block 18 into the locking groove 17.

[0053] When the adjusting block 15 is at the top or bottom of the adjusting groove 13, the first spring 20 pushes the locking block 18 into the locking groove 17 to lock the adjusting block 15.

[0054] Specifically, as shown in Figure 7, the positioning component includes a first positioning groove 12, which is located on the side of the mounting base 3 away from the support base 2. A positioning post 25 is provided on the mounting base 3 at the position corresponding to the first positioning groove 12. A first stop top groove 39 is provided in the movable plate 9, which is connected to the first positioning groove 12. A first stop block 26 is slidably provided in the first stop top groove 39. A third spring 40 is connected between the first stop block 26 and the first stop top groove 39 to push the first stop block 26 into the first positioning groove 12. The first positioning groove 12 and the positioning post 25 are both arc-shaped structures, and the center of the first positioning groove 12 and the positioning post 25 coincides with the center of the second rotating shaft 16. A first stop inclined surface 2601 is provided on the side of the first stop block 26 away from the support base 2.

[0055] When the mounting base 3 is flipped, it drives the positioning pin 25 to rotate and the positioning pin 25 enters the first positioning groove 12. After the positioning pin 25 contacts the first stop inclined surface 2601, it presses the first stop block 26 and presses the first stop block 26 into the first stop top groove 39 until the positioning pin 25 passes through the first stop block 26. Then the third spring 40 pushes the first stop block 26 into the first positioning groove 12, thereby limiting the positioning pin 25.

[0056] Specifically, as shown in Figure 8, the positioning component also includes a second positioning groove 21, which is located at the bottom of the movable plate 9. A second stop top groove 41 is provided in the movable plate 9, and the second stop top groove 41 is connected to the second positioning groove 21. A second stop block 43 is slidably disposed in the second stop top groove 41. A fourth spring 42 is connected between the second stop top groove 41 and the second stop block 43 to push the second stop block 43 into the second positioning groove 21. A second stop inclined surface 4301 is provided at the bottom of the second stop block 43.

[0057] When the mounting base 3 moves, it drives the positioning pin 25 into the second positioning groove 21. After the positioning pin 25 contacts the second stop inclined surface 4301, it presses the second stop block 43 and pushes the second stop block 43 into the second stop top groove 41 until the positioning pin 25 passes through the second stop block 43. Then the fourth spring 42 pushes the second stop block 43 into the second positioning groove 21, thereby limiting the positioning pin 25.

[0058] Specifically, as shown in Figures 4 and 5, the rotation adjustment assembly includes an adjustment through hole 27, which is located on the movable plate 9. A first rotating shaft 10 is positioned at the corresponding location of the adjustment through hole 27 on the support base 2. The first rotating shaft 10 is rotatably disposed within the adjustment through hole 27. A limiting groove 30 is provided within the movable plate 9, communicating with the adjustment through hole 27. A rotation limiting groove 29 is circumferentially formed at the corresponding location of the limiting groove 30 on the first rotating shaft 10. A limiting slider 32 is slidably disposed within the limiting groove 30. A rotation limiting block 33 is positioned at the corresponding location of the limiting groove 29 on the limiting slider 32. A second spring 31 connects the limiting slider 32 and the limiting groove 30, used to push the limiting groove 30 towards the first rotating shaft 10. The top of the movable plate 9 is open... A pressing groove 37 is provided, which is connected to a limiting slide groove 30. A pressing block 11 is slidably arranged in the pressing groove 37. A pressing inclined surface is provided at the bottom of the pressing block 11. A supporting groove 3201 is provided on the limiting slide slider 32, which passes through the limiting slide slider 32. A guide groove 34 is provided on one side of the pressing groove 37. A guide block 35 is provided at the position of the pressing block 11 corresponding to the guide groove 34. The guide block 35 is slidably arranged in the guide groove 34. A traction groove 36 is provided on the side of the pressing block 11 away from the guide block 35. A traction rope 38 is connected in the traction groove 36. Two branch ropes are provided at the other end of the traction rope 38. Each branch rope passes through the bottom of the first gear top groove 39 and the second gear top groove 41 and is connected to the first gear block 26 and the second gear block 43 respectively.

[0059] By pressing the pressing block 11, the pressing block 11 moves downward, and the pressing inclined surface at the bottom of the pressing block 11 cooperates with the abutment groove 3201, thereby driving the limiting slider 32 to move toward the second spring 31. At this time, the rotation limiting block 33 on the limiting slider 32 separates from the rotation limiting groove 29, canceling the rotation limitation on the movable plate 9. The pressing block 11 moves downward, driving the traction rope 38 to tighten, thereby driving the second stop block 43 to enter the second stop top groove 41 or driving the first stop block 26 to enter the first stop top groove 39. The guide groove 34 cooperates with the guide block 35 to guide the pressing block 11, and the traction rope 38 is entered into the traction groove 36. At this time, the limitation on the positioning post 25 is canceled.

[0060] Specifically, as shown in Figure 4, the support assembly includes a support block 6, which is disposed on both sides of the support base 2. The bottom of the support block 6 has multiple sets of support slots 22. The movable plate 9 has a storage slot 24 on the side near the support block 6. A support plate 8 is rotatably disposed on the top of the storage slot 24. The support plate 8 is used to extend into the support slot 22. A through hole 7 is provided in the support slot 22. The through hole 7 passes through the support block 6, the support base 2, and the support plate 8. When the support plate 8 extends into the support slot 22, it is fixed by a support pin 23 passing through the support plate 8.

[0061] Take out the support plate 8 from the storage slot 24, rotate the movable plate 9, and then insert the support plate 8 into the corresponding support slot 22. Then, pass the support pin 23 through the support base 2 and the two sets of support plates 8 to connect the two sets of support plates 8 into one, so that the two sets of movable plates 9 and support plates 8 cooperate to support the support base 2 at the same time, ensuring the stability of the support.

[0062] A liquid ultrafiltration process is also proposed, which is carried out using the above-mentioned apparatus, and the process includes:

[0063] Pretreatment stage: Cell debris and large particulate impurities are removed by deep filtration while retaining virus particles. Buffer is added quantitatively using a multi-channel peristaltic pump to ensure the stability of subsequent ultrafiltration.

[0064] Tangential flow ultrafiltration: It adopts hollow fiber membrane, and drives the ultrafiltration loop to circulate through a high-flow peristaltic pump linked with a transmembrane pressure sensor, and dynamically adjusts the speed.

[0065] Dialysis replacement: The fluid replenishment and drainage are controlled separately through a dual-pump linkage system, and the fluid replenishment rate = drainage rate ± 3% tolerance;

[0066] Stabilizer addition: The stabilizer is added via a micro-peristaltic pump.

[0067] The specific details of this plan are as follows:

[0068] First, adjust the included angle between the support base 2 and the mounting base 3 to adapt to the inclined or curved surface. By pressing the pressing block 11, the pressing block 11 moves downward, and the pressing inclined surface at the bottom of the pressing block 11 engages with the abutment groove 3201, thereby driving the limiting slider 32 to move towards the second spring 31. At this time, the rotation limiting block 33 on the limiting slider 32 separates from the rotation limiting groove 29, canceling the rotation limitation on the movable plate 9. Then, first take out the support plate 8 from the storage groove 24, and then rotate the movable plate 9. If it is installed on an inclined surface, adjust the included angle between the movable plate 9 and the support base 2 to be the same as the inclination angle of the inclined surface. If it is installed on a curved surface, then... Adjust the angle between the movable plate 9 and the support base 2 to 90 degrees, and simultaneously insert the support plate 8 into the corresponding support slot 22. Then, pass the support pin 23 through the support base 2 and the two sets of support plates 8 to connect the two sets of support plates 8 into one unit, so that the two sets of movable plates 9 and support plates 8 cooperate to support the support base 2, ensuring the stability of the support and ensuring the horizontality of the support base 2 and the peristaltic pump body 1. After the adjustment is completed, reset the pressing block 11. At this time, the second spring 31 pushes the limiting slider 32 to move toward the first rotating shaft 10, so that the rotation limiting block 33 cooperates with the rotation limiting groove 29 to limit the rotation of the movable plate 9.

[0069] When the mounting surface of the mounting base 3 changes from an inclined surface to a curved surface, first press the pressing block 11. At this time, the pressing block 11 moves downward, causing the traction rope 38 to tighten, which in turn causes the second stop block 43 to be retracted into the second stop top groove 41. The guide groove 34 and the guide block 35 cooperate to guide the pressing block 11, and the traction rope 38 is retracted into the traction groove 36. At this time, the limiting of the positioning post 25 is released. Then, the mounting base 3 is pulled downward by the handle 5. The positioning post 25 on the mounting base 3 disengages from the second positioning groove 21, and the mounting base 3 drives the adjusting block 15 to slide from top to bottom in the adjusting groove 13 through the second rotating shaft 16. The limiting post 14 limits the rotation of the second rotating shaft 16 until the adjusting block 15 slides to the bottom of the adjusting groove 13. At this time, the first spring 20 pushes the locking block 18 into the locking groove 17 to adjust the position. When block 15 is locked in place and the limiting post 14 is separated from the second rotating shaft 16, the pressing block 11 is released. Then the fourth spring 42 pushes the second stop block 43 to reset, and then the pressing block 11 is reset through the traction rope 38. Then the mounting base 3 can be rotated 180 degrees by the handle 5. When the mounting base 3 is flipped, the positioning post 25 is rotated and the positioning post 25 enters the first positioning groove 12. After the positioning post 25 contacts the first stop inclined surface 2601, it squeezes the first stop block 26 and presses the first stop block 26 into the first stop top groove 39 until the positioning post 25 passes through the first stop block 26. The third spring 40 pushes the first stop block 26 into the first positioning groove 12, thereby limiting the positioning post 25. When the mounting surface of the mounting base 3 changes from an inclined surface to a curved surface, the mounting base 3 is completed.

[0070] When the mounting surface of the mounting base 3 changes from a curved surface to an inclined surface, first press the pressing block 11. At this time, the pressing block 11 moves downward, causing the traction rope 38 to tighten, which in turn causes the first stop block 26 to be pulled into the first stop top groove 39. The guide groove 34 and the guide block 35 cooperate to guide the pressing block 11, and the traction rope 38 is pulled into the traction groove 36. At this time, the limitation on the positioning post 25 is released. Then, the mounting base 3 is rotated outward by 180 degrees through the handle 5. The positioning post 25 on the mounting base 3 is disengaged from the first positioning groove 12. At this time, the pressing block 11 is released, and the third spring 40 pushes the first stop block 26 to reset, which in turn causes the pressing block 11 to reset through the traction rope 38. At this time, the mounting base 3 is pushed upward by the handle 5, and the mounting base 3 is then able to... The second rotating shaft 16 drives the adjusting block 15 to move from bottom to top in the adjusting groove 13. The limiting post 14 limits the rotation of the second rotating shaft 16 until the adjusting block 15 slides to the top of the adjusting groove 13. At this time, the first spring 20 pushes the locking block 18 into the locking groove 17 to lock the adjusting block 15. When the mounting base 3 moves, it drives the positioning post 25 into the second positioning groove 21. After the positioning post 25 contacts the second stop inclined surface 4301, it squeezes the second stop block 43 and presses the second stop block 43 into the second stop top groove 41 until the positioning post 25 passes through the second stop block 43. The fourth spring 42 pushes the second stop block 43 into the second positioning groove 21, thereby limiting the positioning post 25 and completing the change of the mounting surface of the mounting base 3 from a curved surface to an inclined surface.

[0071] Those skilled in the art should understand that the discussion of any of the above embodiments is merely exemplary and is not intended to imply that the scope of the invention (including the claims) is limited to these examples; within the framework of the invention, the technical features of the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity.

[0072] This invention is intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A peristaltic pump for liquid ultrafiltration, characterized in that, include: Peristaltic pump body (1); support base (2), fixed to the bottom of the peristaltic pump body (1); Two sets of movable plates (9) are provided, rotatably mounted on both sides of the support base (2); a mounting seat (3) is provided between the two sets of movable plates (9), with one side being a flat mounting surface and the other side being a curved mounting surface. The mounting seat (3) has multiple sets of mounting holes (4) for mounting on inclined or curved surfaces. A handle (5) is also provided on the mounting seat (3); a flipping assembly is provided inside the movable plates (9) for flipping the mounting seat (3). The flipping assembly includes an adjustment groove (13), which is located on the side of the movable plate (9) near the mounting seat (3). An adjusting block (15) is slidably disposed in the adjusting groove (13). A rotating groove (1502) is provided on the side of the adjusting block (15) near the mounting base (3). A second rotating shaft (16) is provided on the mounting base (3) at the position corresponding to the rotating groove (1502). The second rotating shaft (16) is located within the adjusting groove (13). The flipping assembly also includes a positioning element for limiting the position of the flipped mounting base (3). A rotating adjusting assembly is disposed within the movable plate (9) for adjusting the angle between the movable plate (9) and the support base (2). The rotating adjusting assembly includes an adjusting through hole (27). The adjustment through hole (27) is opened on the movable plate (9). A first rotating shaft (10) is provided on the support base (2) at the position corresponding to the adjustment through hole (27). The first rotating shaft (10) is rotatably disposed in the adjustment through hole (27). A limiting groove (30) is opened in the movable plate (9). The limiting groove (30) communicates with the adjustment through hole (27). A support assembly is disposed between the movable plate (9) and the support base (2) for supporting the support base (2). The support assembly includes a support connecting block (6). The support connecting block (6) is disposed on both sides of the support base (2). The bottom of the support block (6) has multiple sets of support slots (22). The movable plate (9) has a storage slot (24) on the side near the support block (6). The top of the storage slot (24) is rotatably provided with a support plate (8). The support plate (8) is used to extend into the support slot (22). The support slot (22) has a through hole (7). The through hole (7) passes through the support block (6), the support base (2), and the support plate (8). When the support plate (8) extends into the support slot (22), it is fixed by a support pin (23) passing through the support plate (8).

2. The peristaltic pump for liquid ultrafiltration according to claim 1, characterized in that, The adjusting block (15) is provided with a first limiting groove (1501) that passes through the adjusting block (15). The second rotating shaft (16) is provided with a second limiting groove (1601) at the position corresponding to the first limiting groove (1501). A limiting post (14) is provided at the top of the adjusting groove (13) at the position corresponding to the first limiting groove (1501). The limiting post (14) passes through the first limiting groove (1501) and the second limiting groove (1601). When the adjusting block (15) is located at the bottom of the adjusting groove (13), the limiting post (14) separates from the second limiting groove (1601).

3. A peristaltic pump for liquid ultrafiltration according to claim 2, characterized in that, The adjusting block (15) has a top groove (19) on the side away from the mounting base (3). When the adjusting block (15) is located at the top or bottom of the adjusting groove (13), the adjusting groove (13) has a slot (17) at the position corresponding to the top groove (19). The slot (17) has a frustum-shaped structure. A block (18) is slidably disposed in the top groove (19). The end of the block (18) near the slot (17) has a frustum-shaped structure. A first spring (20) is connected between the block (18) and the top groove (19) to push the block (18) into the slot (17).

4. A peristaltic pump for liquid ultrafiltration according to claim 1, characterized in that, The positioning component includes a first positioning groove (12), which is located on the side of the mounting base (3) away from the support base (2). A positioning post (25) is provided on the mounting base (3) at a position corresponding to the first positioning groove (12). A first stop top groove (39) is provided in the movable plate (9), communicating with the first positioning groove (12). A first stop block (26) is slidably disposed within the first stop top groove (39). A third spring (40) is connected between the stop block (26) and the first stop top groove (39) to push the first stop block (26) into the first positioning groove (12); the first positioning groove (12) and the positioning post (25) are both arc-shaped structures, and the center of the first positioning groove (12) and the positioning post (25) coincides with the center of the second rotating shaft (16). The first stop block (26) has a first stop inclined surface (2601) on the side away from the support base (2).

5. A peristaltic pump for liquid ultrafiltration according to claim 4, characterized in that, The positioning component also includes a second positioning groove (21), which is opened at the bottom of the movable plate (9). A second gear top groove (41) is opened in the movable plate (9). The second gear top groove (41) is connected to the second positioning groove (21). A second gear block (43) is slidably arranged in the second gear top groove (41). A fourth spring (42) is connected between the second gear top groove (41) and the second gear block (43) for pushing the second gear block (43) into the second positioning groove (21). A second gear inclined surface (4301) is opened at the bottom of the second gear block (43).

6. A peristaltic pump for liquid ultrafiltration according to claim 5, characterized in that, The first rotating shaft (10) is provided with a rotation limiting groove (29) at the position corresponding to the limiting groove (30) on its circumference. A limiting slider (32) is slidably arranged in the limiting groove (30). A rotation limiting block (33) is provided at the position corresponding to the rotation limiting groove (29) of the limiting slider (32). A second spring (31) is connected between the limiting slider (32) and the limiting groove (30) to push the limiting groove (30) to move toward the first rotating shaft (10).

7. A peristaltic pump for liquid ultrafiltration according to claim 6, characterized in that, The top of the movable plate (9) is provided with a pressing groove (37), which is connected to the limiting slide groove (30). A pressing block (11) is slidably arranged in the pressing groove (37). A pressing slope is provided at the bottom of the pressing block (11). A supporting groove (3201) is provided on the limiting slider (32), which penetrates the limiting slider (32). A guide groove (34) is provided on one side of the pressing groove (37), and the pressing block (11) corresponds to the guide groove (34). A guide block (35) is provided at the position, and the guide block (35) is slidably disposed in the guide groove (34); a traction groove (36) is provided on the side of the pressing block (11) away from the guide block (35), and a traction rope (38) is connected in the traction groove (36). Two branch ropes are provided at the other end of the traction rope (38), and each branch rope passes through the bottom of the first gear top groove (39) and the second gear top groove (41) and is connected to the first gear block (26) and the second gear block (43) respectively.

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