Quantitative evaluation method and device for morphological change of branch artery on aortic arch

Abstract

The invention discloses an aortic arch branch artery morphological change quantitative evaluation method and equipment, and relates to the technical field of quantitative evaluation, and the method comprises the steps: obtaining the cross sectional areas of the proximal end and the telecentric end of each branch blood vessel before an operation based on a preoperative medical image, and calculating the ratio of the cross sectional areas of the proximal end and the telecentric end of each branch blood vessel before the operation; based on the postoperative medical image, obtaining the cross sectional areas of the proximal end and the distal end of each postoperative branch blood vessel, and calculating the ratio of the cross sectional areas of the proximal end and the distal end of each postoperative branch blood vessel; based on the cross sectional area of the proximal end of each branch blood vessel before and after the operation, obtaining the cross sectional area ratio of the proximal end of each branch blood vessel; based on the cross sectional area of the telecentric end of each branch blood vessel before and after the operation, obtaining the ratio of the cross sectional area of the telecentric end of each branch blood vessel; and obtaining a quantitative evaluation result according to the cross sectional area ratio. According to the method and the device, accurate evaluation of the postoperative form and function change of each branch blood vessel can be realized.

Description

Technical Field

[0001] The present application relates to the field of quantitative assessment technology, and in particular to a method and device for quantitatively assessing morphological changes of branch arteries above the aortic arch. Background Art

[0002] The aortic arch vascular system is the main artery maintaining blood supply to the head, neck, and upper limbs. From its proximal to distal ends, it has three major branches: the brachiocephalic trunk (BT), the left common carotid artery (LCCA), and the left subclavian artery (LSA). Stenosis or occlusion of any of these branches can cause serious ischemic complications, including but not limited to dizziness, upper limb weakness, weakened or absent radial artery pulses, and cerebral infarction. In recent years, thoracic endovascular aortic repair (TEVAR) surgery has been widely used to treat aortic disease. However, stent implantation may affect the three major branches of the aortic arch to varying degrees, thereby interfering with the blood supply function of each branch. Therefore, accurately assessing the morphological and functional changes of each branch after surgery has become a key step in optimizing treatment outcomes and reducing the risk of postoperative complications.

[0003] Currently, imaging methods are commonly used to assess the patency of branch vessels after TEVAR surgery. Imaging methods include computed tomography angiography (CTA), magnetic resonance angiography (MRA), and digital subtraction angiography (DSA), supplemented by ultrasound detection of vascular diameter and blood flow velocity. However, existing evaluation methods mainly rely on the doctor's subjective image interpretation and lack accurate pre- and postoperative quantitative comparative analysis, making it difficult to accurately quantify the specific effects of stent implantation on each branch vessel. In addition, when complications such as cerebral ischemia and upper limb ischemia occur after surgery, existing technologies cannot systematically and quantitatively analyze the effects of stents on branch vessels, resulting in a lack of sufficient data support for clinical decision-making. The limitations of this evaluation method make it difficult for clinicians to formulate the best postoperative intervention plan in a timely and effective manner, delaying the best intervention time and increasing the risk of irreversible damage to patients. Therefore, there is an urgent need for a method that can accurately quantify the morphological changes of each branch vessel after TEVAR surgery. Summary of the Invention

[0004] The purpose of this application is to provide a method and device for quantitatively evaluating the morphological changes of the branch arteries above the aortic arch, which can achieve accurate evaluation of the morphological and functional changes of each branch blood vessel after surgery.

[0005] To achieve the above objectives, this application provides the following solutions:

[0006] In a first aspect, the present application provides a method for quantitatively evaluating morphological changes in the branch arteries of the aortic arch, comprising:

[0007] Obtain preoperative and postoperative medical images of thoracic aortic endovascular repair surgery;

[0008] Based on the preoperative medical images, obtaining the cross-sectional area of ​​the proximal end of each branch blood vessel before the operation and the cross-sectional area of ​​the distal end of each branch blood vessel before the operation, and based on the postoperative medical images, obtaining the cross-sectional area of ​​the proximal end of each branch blood vessel after the operation and the cross-sectional area of ​​the distal end of each branch blood vessel after the operation;

[0009] Obtaining a preoperative proximal-distal cross-sectional area ratio of each branch vessel based on the preoperative proximal cross-sectional area of ​​each branch vessel and the preoperative distal cross-sectional area of ​​each branch vessel, and obtaining a postoperative proximal-distal cross-sectional area ratio of each branch vessel based on the postoperative proximal cross-sectional area of ​​each branch vessel and the postoperative distal cross-sectional area of ​​each branch vessel;

[0010] Obtaining a ratio of the proximal cross-sectional areas of each branch vessel based on the preoperative proximal cross-sectional area of ​​each branch vessel and the postoperative proximal cross-sectional area of ​​each branch vessel;

[0011] Obtaining a ratio of the distal cross-sectional areas of each branch vessel based on the preoperative cross-sectional area of ​​the distal end of each branch vessel and the postoperative cross-sectional area of ​​the distal end of each branch vessel;

[0012] Based on the preoperative proximal-distal cross-sectional area ratio of each branch vessel, the postoperative proximal-distal cross-sectional area ratio of each branch vessel, the proximal cross-sectional area ratio of each branch vessel, and the distal cross-sectional area ratio of each branch vessel, a quantitative evaluation of each branch vessel on the aortic arch is performed to obtain a quantitative evaluation result.

[0013] In a second aspect, the present application provides a computer device comprising: a memory, a processor, and a computer program stored on the memory and executable on the processor, wherein the processor executes the computer program to implement the above-described method for quantitatively evaluating morphological changes of branch arteries on the aortic arch.

[0014] In a third aspect, the present application provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the above-mentioned method for quantitatively evaluating morphological changes of branch arteries above the aortic arch.

[0015] In a fourth aspect, the present application provides a computer program product, comprising a computer program, which, when executed by a processor, implements the above-mentioned method for quantitatively evaluating morphological changes of branch arteries above the aortic arch.

[0016] According to the specific embodiments provided in this application, this application discloses the following technical effects:

[0017] The present application provides a method and device for quantitatively evaluating morphological changes in branch arteries above the aortic arch. The method includes obtaining the cross-sectional areas of the proximal and distal ends of each branch vessel before surgery based on preoperative medical images, and obtaining the cross-sectional areas of the proximal and distal ends of each branch vessel after surgery based on postoperative medical images; obtaining the proximal-distal cross-sectional area ratio of each branch vessel before surgery based on the cross-sectional areas of the proximal and distal ends of each branch vessel before surgery, and obtaining the proximal-distal cross-sectional area ratio of each branch vessel after surgery based on the cross-sectional areas of the proximal and distal ends of each branch vessel after surgery; obtaining the proximal cross-sectional area ratio of each branch vessel based on the cross-sectional areas of the proximal ends of each branch vessel before and after surgery; obtaining the distal cross-sectional area ratio of each branch vessel based on the cross-sectional areas of the distal ends of each branch vessel before and after surgery; and obtaining a quantitative evaluation result based on the proximal-distal cross-sectional area ratio of each branch vessel before and after surgery, as well as the proximal cross-sectional area ratio and distal cross-sectional area ratio of each branch vessel.

[0018] This application provides a quantitative parameter index for describing the morphological changes of the three major branch blood vessels by obtaining the cross-sectional area of ​​the proximal and distal ends of each branch blood vessel before surgery and the cross-sectional area of ​​the proximal and distal ends of each branch blood vessel after surgery, so as to better quantify the postoperative repair effect, help doctors evaluate whether the surgery has achieved the expected therapeutic effect, and promptly detect possible complications or changes in vascular morphology. In addition, the quantitative evaluation parameters obtained in this application can be completely based on clinical medical imaging information, without the need for clinically increasing measurement costs, mainly reprocessing clinical medical images, and will not increase the burden on patients. Moreover, the measurement process of these morphological parameters is non-invasive and will not cause any impact on the patient's body. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 This is a diagram of the application environment of a method for quantitatively evaluating morphological changes of branch arteries above the aortic arch in one embodiment of the present application;

[0021] Figure 2 A flowchart of a method for quantitatively evaluating morphological changes of supra-aortic arch branch arteries provided in one embodiment of the present application;

[0022] Figure 3a A schematic diagram of a preoperative medical image and a corresponding preoperative three-dimensional model provided in one embodiment of the present application;

[0023] Figure 3b A schematic diagram of a postoperative medical image and a corresponding postoperative three-dimensional model provided in one embodiment of the present application;

[0024] Figure 4 A schematic diagram of the locations of the three major branch blood vessels provided in one embodiment of the present application;

[0025] Figure 5 A schematic diagram of the structure of a computer device provided in one embodiment of the present application. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0027] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the present application is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0028] The quantitative evaluation method for morphological changes of the aortic arch branch arteries provided in the embodiment of the present application can be applied to Figure 1In the application environment shown, the terminal 102 communicates with the server 104 via a network. The data storage system can store data that the server 104 needs to process. The data storage system can be set up separately, integrated on the server 104, or placed on the cloud or other servers. The terminal 102 can send preoperative and postoperative medical images to the server 104. Based on the preoperative medical images, the server 104 obtains the preoperative cross-sectional areas of the proximal and distal ends of each branch vessel and calculates the preoperative proximal-distal cross-sectional area ratio of each branch vessel; based on the postoperative medical images, the server 104 obtains the postoperative cross-sectional areas of the proximal and distal ends of each branch vessel and calculates the postoperative proximal-distal cross-sectional area ratio of each branch vessel; based on the preoperative and postoperative cross-sectional areas of the proximal ends of each branch vessel, the proximal cross-sectional area ratio of each branch vessel is obtained; based on the preoperative and postoperative cross-sectional areas of the distal ends of each branch vessel, the distal cross-sectional area ratio of each branch vessel is obtained; and based on the above cross-sectional area ratios, a quantitative evaluation result is obtained. The server 104 can provide feedback of the obtained quantitative evaluation result to the terminal 102.

[0029] The terminal 102 may be, but is not limited to, various desktop computers, laptop computers, and IoT devices. The server 104 may be implemented as an independent server or a server cluster consisting of multiple servers, or a cloud server.

[0030] In an exemplary embodiment, Figure 2 As shown, a method for quantitatively evaluating the morphological changes of the branch arteries of the aortic arch is provided. The method is executed by a computer device, specifically a computer device such as a terminal or a server, and can also be executed by a terminal and a server together. In the embodiment of the present application, the method is applied to Figure 1 The server 104 in FIG. 1 is taken as an example to illustrate the process, including the following steps 201 to 206. In which:

[0031] Step 201: Obtain preoperative medical images and postoperative medical images of thoracic aortic endovascular repair surgery.

[0032] Step 202: Based on the preoperative medical images, the cross-sectional areas of the proximal ends of the branch vessels and the distal ends of the branch vessels before the operation are obtained, and based on the postoperative medical images, the cross-sectional areas of the proximal ends of the branch vessels and the distal ends of the branch vessels after the operation are obtained.

[0033] Step 203, based on the cross-sectional area of ​​the proximal end of each branch vessel before the operation and the cross-sectional area of ​​the distal end of each branch vessel before the operation, obtain the ratio of the proximal and distal cross-sectional areas of each branch vessel before the operation, and based on the cross-sectional area of ​​the proximal end of each branch vessel after the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation, obtain the ratio of the proximal and distal cross-sectional areas of each branch vessel after the operation.

[0034] Step 204 : Based on the cross-sectional area of ​​the proximal end of each branch vessel before surgery and the cross-sectional area of ​​the proximal end of each branch vessel after surgery, a ratio of the proximal end cross-sectional area of ​​each branch vessel is obtained.

[0035] Step 205 : Based on the cross-sectional area of ​​the distal end of each branch vessel before the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation, a ratio of the distal cross-sectional area of ​​each branch vessel is obtained.

[0036] In step 206, a quantitative evaluation is performed on each branch vessel on the aortic arch based on the preoperative proximal-distal cross-sectional area ratio of each branch vessel, the postoperative proximal-distal cross-sectional area ratio of each branch vessel, the proximal cross-sectional area ratio of each branch vessel, and the distal cross-sectional area ratio of each branch vessel to obtain a quantitative evaluation result.

[0037] By implementing the above-mentioned steps 201 to 206, the present application provides a quantitative parameter index for describing the morphological changes of the three major branch vessels by obtaining the cross-sectional area of ​​the proximal and distal ends of each branch vessel before surgery and the cross-sectional area of ​​the proximal and distal ends of each branch vessel after surgery, thereby better quantifying the postoperative repair effect, helping doctors evaluate whether the surgery has achieved the expected therapeutic effect, and promptly discovering possible complications or changes in vascular morphology. In addition, the quantitative evaluation parameters obtained in the present application can be completely based on clinical medical imaging information, without the need for clinically increasing measurement costs, mainly reprocessing clinical medical images, and will not increase the burden on patients. Moreover, the measurement process of these morphological parameters is non-invasive and will not cause any impact on the patient's body.

[0038] Furthermore, obtaining preoperative medical images and postoperative medical images of the thoracic aortic endovascular repair surgery in step 201 specifically includes:

[0039] Computed tomography angiography, magnetic resonance angiography (MRI), or digital subtraction angiography were used to collect preoperative and postoperative clinical medical images of patients undergoing endovascular aortic repair.

[0040] Furthermore, in step 202, based on the preoperative medical image, the cross-sectional area of ​​the proximal end of each branch vessel and the cross-sectional area of ​​the distal end of each branch vessel before the operation are obtained, and based on the postoperative medical image, the cross-sectional area of ​​the proximal end of each branch vessel and the cross-sectional area of ​​the distal end of each branch vessel after the operation are obtained, specifically including:

[0041] Step 2021: Based on a 3D model extraction algorithm (e.g., Mimics software), the preoperative medical image and the postoperative medical image are reconstructed into 3D models to obtain a preoperative 3D model and a postoperative 3D model. Combined with manual verification, the preoperative and postoperative 3D models with accurate lesion location can be reconstructed. Figure 3a As shown, the postoperative medical images and the corresponding postoperative 3D models are shown in Figure 3b shown.

[0042] Step 2022: Based on the preoperative 3D model and the postoperative 3D model, the morphological parameters of each branch vessel (including the brachiocephalic artery, the left common carotid artery, and the left subclavian artery) are obtained, such as Figure 4 As shown, the cross-sectional area of ​​the proximal end of each branch vessel before the operation, the cross-sectional area of ​​the distal end of each branch vessel before the operation, the cross-sectional area of ​​the proximal end of each branch vessel after the operation, and the cross-sectional area of ​​the distal end of each branch vessel after the operation are obtained respectively. Moreover, when the cross-sectional area of ​​the proximal end of each branch vessel and the cross-sectional area of ​​the distal end of each branch vessel can be directly obtained from the medical image, it is also possible not to perform the three-dimensional model reconstruction operation, and thus directly obtain them from the medical image. Among them, since the distal end of the LCCA branch vessel is located at the bifurcation of the internal and external carotid arteries and is far away from the proximal end, if the clinical medical image is captured at this place, it can be used as the measurement position of the cross-sectional area of ​​the distal end of the LCCA branch vessel before the operation. Taking into account that the range of clinical medical imaging may not capture the imaging situation here, the distance between the proximal end and the distal end of the LCCA branch vessel before and after the operation (L LCCA ) The cross-sectional area of ​​the distal end of the LCCA branch vessel was measured at the same position before surgery. In this embodiment, L LCCA =3cm. Based on this, the morphological parameters of each branch vessel (unit: cm 2 ) as shown in Table 1:

[0043] Table 1 Summary of the cross-sectional area data of the proximal and distal ends of each branch before and after TEVAR surgery

[0044]

[0045] Furthermore, based on a basic rule of arterial vessels, that is, along the anatomical direction of arterial vessels, the diameter of arterial vessels becomes thinner from the proximal end to the distal end, the cross-sectional area difference between the proximal end and the distal end of a specific arterial vessel can be evaluated. Specifically, step 203 is performed to obtain the ratio of the proximal and distal cross-sectional areas of each branch vessel before the operation (i.e., the ratio between the cross-sectional area of ​​the proximal end of each branch vessel before the operation and the cross-sectional area of ​​the distal end of each branch vessel before the operation), and based on the cross-sectional area of ​​the proximal end of each branch vessel after the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation, the ratio of the proximal and distal cross-sectional areas of each branch vessel after the operation (i.e., the ratio between the cross-sectional area of ​​the proximal end of each branch vessel after the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation) is obtained. The calculation formulas for the ratio of the proximal and distal cross-sectional areas of each branch vessel before the operation and the ratio of the proximal and distal cross-sectional areas of each branch vessel after the operation are respectively:

[0046]

[0047] Among them, AR X,pre AR is the ratio of the proximal and distal cross-sectional areas of each branch vessel before surgery; X,post CSA is the ratio of the proximal and distal cross-sectional areas of each branch vessel after surgery; X,distal,pre CSA is the cross-sectional area of ​​the distal end of each branch vessel before surgery; X,proximal,pre CSA is the cross-sectional area of ​​the proximal end of each branch vessel before surgery; X,distal,post CSA is the cross-sectional area of ​​the distal end of each branch vessel after surgery; X,proximal,post is the cross-sectional area of ​​the proximal end of each branch vessel after surgery; X is any branch vessel; distal is the distal end; proximal is the proximal end; post is postoperative; pre is preoperative.

[0048] Generally speaking, the cross-sectional area of ​​the proximal end of a branch vessel is larger than that of the distal end of the branch vessel, so AR X The value is usually less than 1. However, for patients who have undergone TEVAR surgery, the three major branch blood vessels on the aortic arch are affected to varying degrees by the implanted stents, which will cause this value to increase, or even become obviously abnormal. Therefore, based on the ratio of the proximal and distal cross-sectional areas of each branch blood vessel before surgery and the ratio of the proximal and distal cross-sectional areas of each branch blood vessel after surgery, a quantitative evaluation of the morphological changes of each branch blood vessel can be obtained, specifically including: performing a first judgment operation on each branch blood vessel; the first judgment operation is to determine whether the change value of the proximal and distal cross-sectional area ratio of the current branch blood vessel after surgery is larger than the change value of the proximal and distal cross-sectional area ratio of the current branch blood vessel before surgery; if so, it indicates that the morphology of the current branch blood vessel is affected by the implanted stent; if not, it indicates that the morphology of the current branch blood vessel is not affected by the implanted stent. In this embodiment, the patient had AR before surgeryLSA,pre =0.49, increased to AR after surgery LSA,post =5.25, showing an abnormal increase compared to the preoperative level. Based on this, we can conclude that: when AR X,post The larger the value, the higher the CSA X,proximal,post The smaller the value, the more obvious the branch vessel is affected by the implanted stent.

[0049] Furthermore, based on the cross-sectional area data of the proximal and distal ends of each branch vessel before and after surgery, the ratio of the proximal cross-sectional area of ​​each branch vessel before surgery to the proximal cross-sectional area of ​​each branch vessel after surgery (AR X,proxmial ) size to determine the morphological changes of the proximal ends of the three major branch vessels on the aortic arch before and after surgery. Specifically, step 204 is to obtain the ratio of the proximal cross-sectional areas of each branch vessel based on the preoperative and postoperative cross-sectional areas of the proximal ends of each branch vessel. The formula for calculating the ratio of the proximal cross-sectional areas of each branch vessel is:

[0050]

[0051] Among them, AR X,proxmial CSA is the ratio of the proximal cross-sectional area of ​​each branch vessel (i.e., the ratio of the proximal cross-sectional area of ​​each branch vessel before surgery to the proximal cross-sectional area of ​​each branch vessel after surgery), which is a dimensionless parameter greater than or equal to 0; X,proximal,post CSA is the cross-sectional area of ​​the proximal end of each branch vessel after surgery; X,proximal,pre is the cross-sectional area of ​​the proximal end of each branch vessel before surgery; X is any branch vessel; proximal is the proximal end; post is postoperative; pre is preoperative.

[0052] Generally speaking, the ratio of the proximal cross-sectional area of ​​each branch vessel, AR, can be used to calculate the X,proxmialThe impact of TEVAR on the various branch vessels of the aortic arch was quantitatively assessed. The degree of proximal stenosis of each branch vessel after surgery was determined based on the proximal cross-sectional area ratio of each branch vessel. This process specifically involved performing a second determination on each branch vessel. The second determination was as follows: if the proximal cross-sectional area ratio of the branch vessel was greater than or equal to 1, the postoperative proximal diameter of the branch vessel was no less than preoperative, indicating that the stent implantation did not cause proximal stenosis of the branch vessel, i.e., no proximal stenosis of the branch vessel. If the proximal cross-sectional area ratio of the branch vessel was greater than 0 but less than 1, it indicated that the proximal diameter of the branch vessel had decreased after surgery. The smaller the value, the narrower the proximal lumen of the branch vessel after surgery, and the greater the likelihood of localized stenosis caused by the stent, i.e., localized stenosis of the proximal branch vessel. If the proximal cross-sectional area ratio of the branch vessel was equal to 0, it indicated that the branch vessel was completely covered by the stent. This situation occurs in TEVAR without LSA fenestration, indicating that the proximal branch vessel is completely occluded.

[0053] In addition, theoretically, the stent released after TEVAR surgery usually does not directly affect the distal ends of the three major branches of the aortic arch. However, during the research process, we still observed that the cross-sectional area of ​​the distal end of a branch vessel was significantly reduced after TEVAR surgery. For example, the LSA branch vessel of the patient shown in this example was not only found to be significantly narrowed at the proximal end due to the release of the stent, but the cross-sectional area of ​​the proximal end of the LSA branch vessel was reduced from 0.84 cm before surgery to 2 Reduced to 0.04cm after surgery 2 The cross-sectional area of ​​the distal end of the LSA branch vessel that is not in direct contact with the implanted stent (CSA LSA,proximal ) also increased from 0.41cm before surgery 2 Reduced to 0.21cm after surgery 2 . In fact, the patient was indeed clinically observed to have a weak left radial artery after the operation. The occurrence of such adverse clinical consequences may be related to the overall morphological changes of the branch vessels and the overall atrophy of the lumen, which in turn causes the local blood perfusion to be affected. Based on the above analysis, another parameter is proposed to quantitatively describe the morphological changes of the three major branches on the aortic arch after TEVAR surgery - the ratio of the distal cross-sectional areas of each branch vessel (that is, the ratio between the cross-sectional area of ​​the distal end of each branch vessel before the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation). Therefore, step 205 is executed to obtain the ratio of the distal cross-sectional areas of each branch vessel based on the cross-sectional area of ​​the distal end of each branch vessel before the operation and the cross-sectional area of ​​the distal end of each branch vessel after the operation. The calculation formula for the ratio of the distal cross-sectional areas of each branch vessel is:

[0054]

[0055] Among them, AR X,distal CSA is the ratio of the distal cross-sectional area of ​​each branch vessel; X,distal,post CSA is the cross-sectional area of ​​the distal end of each branch vessel after surgery; X,distal,pre is the cross-sectional area of ​​the distal end of each branch vessel before surgery; X is any branch vessel; distal is the distal end; post is postoperative; pre is preoperative.

[0056] Therefore, the degree of atrophy of the distal end of each branch vessel after surgery can be further obtained based on the distal cross-sectional area ratio of each branch vessel, specifically including: performing a third judgment operation on each branch vessel; the third judgment operation is: if the distal cross-sectional area ratio of the current branch vessel is greater than or equal to 1, it indicates that the diameter of the distal end of the current branch vessel after surgery is not less than that before surgery, and the lumen of the current branch vessel after surgery is increased, that is, the distal end of the current branch vessel has not atrophied; if the distal cross-sectional area ratio of the current branch vessel is greater than 0 and less than 1, it indicates that the diameter of the distal end of the current branch vessel after surgery is reduced, and the smaller the value, the narrower the lumen of the distal end of the current branch vessel after surgery, and the greater the possibility of atrophy of the lumen of the current branch vessel caused by surgery, that is, the distal end of the current branch vessel has atrophy; if the distal cross-sectional area ratio of the current branch vessel is equal to 0, it indicates that the current branch vessel has been completely covered by the stent. This situation exists in TEVAR surgery without LSA fenestration, that is, the distal end of the current branch vessel is completely occluded.

[0057] By proposing these new morphological parameter concepts, we can quantitatively describe the changes in the state of the three major branch vessels of the aortic arch in patients before and after TEVAR surgery, providing a new monitoring method for clinical practice. Taking the patient in this embodiment as an example, by using the quantitative assessment method of morphological changes in the branch arteries of the aortic arch in this application, we can calculate the data shown in Table 2:

[0058] Table 2 Summary of different morphological parameters of each branch vessel before and after TEVAR surgery

[0059]

[0060] It can be seen that for the patient in this embodiment, after TEVAR surgery, the LSA branch vessels were significantly affected, and the relevant morphological parameters proposed in this application capture this point very well. The weakness of the patient's left radial artery after surgery may also be directly related to the abnormality of local morphological parameters. The overall performance of the parameters related to the other two major branches is normal, indicating that the morphology of the BT branch vessels and the LCCA branch vessels was not significantly affected after surgery. Clinically, the various morphological parameters may show differences for different patients. Doctors can also use these morphological parameters to quantitatively monitor the three major branches on the patient's aortic arch after surgery, so as to provide valuable morphological information for adverse postoperative symptoms such as stroke, spinal cord ischemia, and insufficient blood supply to the upper limbs that may occur after TEVAR surgery.

[0061] The present application also provides an application scenario, which applies the above-mentioned method for quantitatively evaluating the morphological changes of the branch arteries of the aortic arch. Specifically: the method for quantitatively evaluating the morphological changes of the branch arteries of the aortic arch provided in this embodiment can be applied to the scenario of quantitatively evaluating the morphological changes of the branch arteries of the aortic arch. The scenario of quantitatively evaluating the morphological changes of the branch arteries of the aortic arch includes a morphological parameter generation link and a morphological parameter display link; the morphological parameter generation link is used to obtain morphological parameters based on medical influences; the morphological parameter display link is used to display morphological parameters. The method for quantitatively evaluating the morphological changes of the branch arteries of the aortic arch of the present application belongs to the morphological parameter generation link.

[0062] In an exemplary embodiment, a computer device is provided. The computer device may be a server or a terminal. The internal structure diagram thereof may be as follows: Figure 5 As shown. The computer device includes a processor, a memory, an input / output interface (Input / Output, abbreviated as I / O) and a communication interface. The processor, memory and input / output interface are connected through a system bus, and the communication interface is connected to the system bus through the input / output interface. The processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and computer program in the non-volatile storage medium. The database of the computer device is used to store video tag processing data. The input / output interface of the computer device is used to exchange information between the processor and an external device. The communication interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, a video tag processing method is implemented.

[0063] Those skilled in the art will understand that Figure 5The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than shown in the figure, or combine certain components, or have a different component arrangement.

[0064] In an exemplary embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor implements the steps in the above method embodiments when executing the computer program.

[0065] In an exemplary embodiment, a computer-readable storage medium is provided, storing a computer program. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0066] In an exemplary embodiment, a computer program product is provided, including a computer program. When the computer program is executed by a processor, the steps in the above method embodiments are implemented.

[0067] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0068] Those skilled in the art will understand that all or part of the processes in the above-mentioned embodiment methods can be implemented by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, database or other media used in the embodiments provided in this application may include at least one of non-volatile and volatile memory. Non-volatile memory may include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory may include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM may be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0069] The databases involved in the various embodiments provided herein may include at least one of a relational database and a non-relational database. Non-relational databases may include, but are not limited to, distributed databases based on blockchains. The processors involved in the various embodiments provided herein may include, but are not limited to, general-purpose processors, central processing units, graphics processing units, digital signal processors, programmable logic units, data processing logic units based on quantum computing, and the like.

[0070] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0071] This document uses specific examples to illustrate the principles and implementation methods of this application. The description of the above examples is only intended to help understand the method and core concept of this application. At the same time, for those skilled in the art, based on the concept of this application, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting this application.

Claims

1. A method for quantitatively evaluating morphological changes of the aortic arch branch arteries, characterized in that: include: Obtain preoperative and postoperative medical images of thoracic aortic endovascular repair surgery; Based on the preoperative medical images, obtaining the cross-sectional area of ​​the proximal end of each branch blood vessel before the operation and the cross-sectional area of ​​the distal end of each branch blood vessel before the operation, and based on the postoperative medical images, obtaining the cross-sectional area of ​​the proximal end of each branch blood vessel after the operation and the cross-sectional area of ​​the distal end of each branch blood vessel after the operation; Obtaining a preoperative proximal-distal cross-sectional area ratio of each branch vessel based on the preoperative proximal cross-sectional area of ​​each branch vessel and the preoperative distal cross-sectional area of ​​each branch vessel, and obtaining a postoperative proximal-distal cross-sectional area ratio of each branch vessel based on the postoperative proximal cross-sectional area of ​​each branch vessel and the postoperative distal cross-sectional area of ​​each branch vessel; Obtaining a ratio of the proximal cross-sectional areas of each branch vessel based on the preoperative proximal cross-sectional area of ​​each branch vessel and the postoperative proximal cross-sectional area of ​​each branch vessel; Obtaining a ratio of the distal cross-sectional areas of each branch vessel based on the preoperative cross-sectional area of ​​the distal end of each branch vessel and the postoperative cross-sectional area of ​​the distal end of each branch vessel; Based on the preoperative proximal-distal cross-sectional area ratio of each branch vessel, the postoperative proximal-distal cross-sectional area ratio of each branch vessel, the proximal cross-sectional area ratio of each branch vessel, and the distal cross-sectional area ratio of each branch vessel, a quantitative evaluation of each branch vessel on the aortic arch is performed to obtain a quantitative evaluation result.

2. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 1, characterized in that: Obtaining the cross-sectional area of ​​the proximal end of each branch vessel and the cross-sectional area of ​​the distal end of each branch vessel before the operation based on the preoperative medical image, and obtaining the cross-sectional area of ​​the proximal end of each branch vessel and the cross-sectional area of ​​the distal end of each branch vessel after the operation based on the postoperative medical image, specifically including: Based on a three-dimensional model extraction algorithm, the preoperative medical image and the postoperative medical image are respectively reconstructed into three-dimensional models to obtain a preoperative three-dimensional model and a postoperative three-dimensional model; Based on the preoperative three-dimensional model, the cross-sectional area of ​​the proximal end of each branch blood vessel and the cross-sectional area of ​​the distal end of each branch blood vessel before the operation are obtained, and based on the postoperative three-dimensional model, the cross-sectional area of ​​the proximal end of each branch blood vessel and the cross-sectional area of ​​the distal end of each branch blood vessel after the operation are obtained.

3. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 1, characterized in that: The calculation formulas for the ratio of the proximal and distal cross-sectional areas of each branch vessel before surgery and the ratio of the proximal and distal cross-sectional areas of each branch vessel after surgery are respectively: Among them, AR X,pre AR is the ratio of the proximal and distal cross-sectional areas of each branch vessel before surgery; X,post CSA is the ratio of the proximal and distal cross-sectional areas of each branch vessel after surgery; X,distal,pre CSA is the cross-sectional area of ​​the distal end of each branch vessel before surgery; X,proximal,pre CSA is the cross-sectional area of ​​the proximal end of each branch vessel before surgery; X,distal,post CSA is the cross-sectional area of ​​the distal end of each branch vessel after surgery; X,proximal,post is the cross-sectional area of ​​the proximal end of each branch vessel after surgery; X is any branch vessel; distal is the distal end; proximal is the proximal end; post is postoperative; pre is preoperative.

4. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 1, characterized in that: The calculation formula for the ratio of the proximal cross-sectional areas of the branch vessels is: Among them, AR X,proxmial CSA is the ratio of the proximal cross-sectional area of ​​each branch vessel; X,proximal,post CSA is the cross-sectional area of ​​the proximal end of each branch vessel after surgery; X,proximal,pre is the cross-sectional area of ​​the proximal end of each branch vessel before surgery; X is any branch vessel; proximal is the proximal end; post is postoperative; pre is preoperative.

5. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 1, characterized in that: The calculation formula for the distal cross-sectional area ratio of each branch vessel is: Among them, AR X,distal CSA is the ratio of the distal cross-sectional area of ​​each branch vessel; X,distal,post CSA is the cross-sectional area of ​​the distal end of each branch vessel after surgery; X,distal,pre is the cross-sectional area of ​​the distal end of each branch vessel before surgery; X is any branch vessel; distal is the distal end; post is postoperative; pre is preoperative.

6. The method for quantitatively evaluating morphological changes of supra-aortic arch branch arteries according to claim 1, characterized in that: The quantitative assessment results include the morphological changes of each branch vessel, the degree of stenosis of the proximal end of each branch vessel after surgery, and the degree of atrophy of the distal end of each branch vessel after surgery. The branch vessels on the aortic arch are quantitatively assessed based on the preoperative proximal-distal cross-sectional area ratio of each branch vessel, the postoperative proximal-distal cross-sectional area ratio of each branch vessel, the proximal cross-sectional area ratio of each branch vessel, and the distal cross-sectional area ratio of each branch vessel, to obtain the quantitative assessment results, which specifically include: Obtaining morphological change results of each branch vessel based on the ratio of the proximal and distal cross-sectional areas of each branch vessel before the operation and the ratio of the proximal and distal cross-sectional areas of each branch vessel after the operation; Based on the ratio of the proximal cross-sectional areas of the branch vessels, the degree of stenosis of the proximal end of each branch vessel after surgery is obtained; Based on the ratio of the distal cross-sectional areas of the branch vessels, the degree of atrophy of the distal end of each branch vessel after surgery is obtained.

7. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 6, characterized in that: Based on the preoperative proximal-distal cross-sectional area ratio of each branch vessel and the postoperative proximal-distal cross-sectional area ratio of each branch vessel, the morphological change results of each branch vessel are obtained, specifically including: performing a first determination operation on each branch blood vessel; The first determination operation is: Determine whether the ratio of the proximal to distal cross-sectional areas of the current branch vessels increases after surgery compared to the ratio before surgery; If so, it indicates that the morphology of the current branch blood vessel is affected by the implanted stent; if not, it indicates that the morphology of the current branch blood vessel is not affected by the implanted stent.

8. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 6, characterized in that: Based on the proximal cross-sectional area ratio of each branch vessel, the degree of stenosis of the proximal end of each branch vessel after surgery is obtained, specifically including: performing a second determination operation on each branch blood vessel; The second determination operation is: If the proximal cross-sectional area ratio of the current branch vessel is greater than or equal to 1, it indicates that there is no stenosis at the proximal end of the current branch vessel; If the proximal cross-sectional area ratio of the current branch vessel is greater than 0 and less than 1, it indicates that there is local stenosis at the proximal end of the current branch vessel; If the proximal cross-sectional area ratio of the current branch vessel is equal to 0, it indicates that the proximal end of the current branch vessel is completely occluded.

9. The method for quantitatively evaluating morphological changes of supra-aortic arch arteries according to claim 6, characterized in that: Based on the distal cross-sectional area ratio of each branch vessel, the degree of atrophy of the distal end of each branch vessel after surgery is obtained, specifically including: performing a third determination operation on each branch blood vessel; The third determination operation is: If the distal cross-sectional area ratio of the current branch vessel is greater than or equal to 1, it indicates that the distal end of the current branch vessel has no atrophy; If the distal cross-sectional area ratio of the current branch vessel is greater than 0 and less than 1, it indicates that the distal end of the current branch vessel is atrophic; If the distal cross-sectional area ratio of the current branch vessel is equal to 0, it indicates that the distal end of the current branch vessel is completely occluded.

10. A computer device comprising: A memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the method for quantitatively evaluating morphological changes of the branch arteries of the aortic arch according to any one of claims 1 to 9.

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