Composite vitamin mineral powder and preparation method thereof

Abstract

The invention provides composite vitamin mineral powder. The composite vitamin mineral powder comprises the following active ingredients: 0.12-0.36 wt% of vitamin E; fish oil: 11.9 to 60 wt%; 0-9 wt% of an oil phase solvent; and 3.6 to 7.2 wt% of a mineral substance composition. The invention also provides a preparation method of the composite vitamin mineral powder. The preparation method comprises the following steps: uniformly mixing the oil-phase raw material and the water-phase raw material; carrying out high-speed shearing emulsification treatment to obtain a mixed emulsion; carrying out ultrahigh-pressure microjet homogenization treatment on the mixed emulsion to obtain a homogenized mixed emulsion; and mixing the homogenized mixed emulsion with the dry powder matrix, and then carrying out drying treatment to obtain the composite vitamin mineral powder.

Description

Technical Field

[0001] The present invention relates to a nutritional preparation and a preparation method thereof, and in particular to a mineral powder and a preparation method thereof. Background Art

[0002] Hair loss is a common skin and beauty problem that significantly affects the quality of life of many people.

[0003] Current anti-hair loss products are primarily available in topical liquids or creams. A major limitation of these products is that the bioavailability and stability of their active ingredients are often limited, limiting their potential for preventing hair loss.

[0004] Furthermore, most existing anti-hair loss products fail to fully consider the synergistic effects of various nutrients required to promote hair growth and maintain hair health. Summary of the Invention

[0005] One of the purposes of the present invention is to provide a multivitamin mineral powder, which not only has an excellent anti-hair loss effect, but also has significantly improved ingredient stability and bioavailability.

[0006] In order to achieve the above object, the present invention provides a multivitamin mineral powder, the active ingredients of which include:

[0007]

[0008] Furthermore, in the multivitamin mineral compound described in the present invention, the mass percentage of each component is:

[0009]

[0010]

[0011] Furthermore, in the multivitamin mineral of the present invention, the vitamin E is selected from D-α-tocopherol.

[0012] Furthermore, in the multivitamin mineral of the present invention, the oil phase solvent includes at least one of medium chain triglycerides and olive oil.

[0013] Furthermore, in the multivitamin mineral of the present invention, the mineral composition includes an Fe-containing component, a Mg-containing component, a Ca-containing component and a K-containing component.

[0014] Furthermore, the multivitamin minerals described in the present invention include:

[0015] The Fe-containing component is selected from at least one of ferrous gluconate, ferrous sulfate, and ferric citrate;

[0016] The Mg-containing component is selected from at least one of magnesium oxide, magnesium gluconate, and magnesium carbonate;

[0017] The calcium-containing component is selected from at least one of: calcium hydrogen phosphate, calcium citrate, and calcium acetate;

[0018] The K-containing component is selected from at least one of potassium chloride, dipotassium hydrogen phosphate, and potassium citrate.

[0019] Furthermore, in the multivitamin mineral of the present invention, when the following components are contained, their contents satisfy at least one of the following conditions:

[0020] Calcium hydrogen phosphate 1.15-2.05wt%;

[0021] Magnesium oxide 1.15-2.15wt%;

[0022] Potassium chloride 1.15-2.3wt%;

[0023] Calcium citrate 1.3-2.15wt%;

[0024] Magnesium gluconate 1.4-2.3wt%;

[0025] Dipotassium hydrogen phosphate 1.55-2.4wt%;

[0026] Calcium acetate 1.75-2.4wt%;

[0027] Magnesium carbonate 1.75-1.95wt%;

[0028] Potassium citrate 1.75-2.05wt%.

[0029] Furthermore, in the multivitamin mineral of the present invention, the additives include at least one of an acidity regulator, a sweetener, an emulsifier, an antibacterial agent, and a flavor.

[0030] Another object of the present invention is to provide a method for preparing a multivitamin mineral powder. This method uses microfluidization technology to effectively process the active ingredients into a nano-scale emulsion, greatly improving its stability and bioavailability. Subsequently, spray drying technology is used to further process the nanoemulsion into a microcapsule powder that is easy to store and transport, thereby ensuring the effectiveness and stability of the ingredients during oral administration.

[0031] In order to achieve the above object, the present invention also provides a method for preparing the multivitamin mineral powder as described above, comprising the steps of:

[0032] 100: Mix the oil phase raw materials and the water phase raw materials evenly;

[0033] 200: Perform high-speed shear emulsification treatment to obtain a mixed emulsion;

[0034] 300: performing ultra-high pressure microfluidization homogenization treatment on the mixed emulsion to obtain a homogenized mixed emulsion;

[0035] 400: The homogenized mixed emulsion is mixed with a dry powder matrix, and then dried to obtain a multivitamin mineral powder.

[0036] Furthermore, in step 100 of the preparation method of the present invention, the oil phase raw material includes:

[0037] Vitamin E 0.12-0.36wt%;

[0038] Fish oil 11.9-60wt%;

[0039] Oil phase solvent 0-9wt%;

[0040] The aqueous phase raw materials include:

[0041] Mineral composition 3.6-7.2 wt%;

[0042] Additives and water balance.

[0043] Furthermore, in step 200 of the preparation method of the present invention, the temperature of the high-speed shear emulsification treatment is 40-60° C., the treatment time is 5 min-10 min; and the rotation speed of the high-speed shear emulsification is 11000 rpm-18000 rpm.

[0044] Furthermore, in step 300 of the preparation method of the present invention, an ultra-high pressure microfluidizer is used to first homogenize at a pressure of 200 to 600 bar for 1 to 3 times; and then homogenize at a pressure of 200 to 800 bar for 1 to 2 times.

[0045] Furthermore, in step 400 of the preparation method described in the present invention, the drying treatment adopts a spray drying process, wherein the inlet air temperature of the spray dryer is 160-210°C, the outlet air temperature of the spray dryer is 60-110°C, and the feed rate of the spray dryer is 10-30 mL / min.

[0046] The multivitamin mineral powder and the preparation method thereof of the present invention have the following advantages and beneficial effects:

[0047] In addition, the multivitamin mineral powder described in the present invention is suitable for oral administration. It not only performs well in anti-hair loss effects, but also has significantly improved stability and bioavailability of ingredients, meeting the market's urgent demand for efficient and safe anti-hair loss products.

[0048] The method for preparing the multivitamin mineral powder of the present invention premixes the oil phase and the water phase to prepare a water-in-oil emulsion. The water-in-oil technology can fully enable the fish oil, vitamin E, and mineral composition components in the powder to fully exert their efficacy, improve the stability and bioavailability of the above components, enable better absorption by the human body, and fully exert their efficacy in treating hair loss.

[0049] The method for preparing the multivitamin mineral powder of the present invention uses advanced microfluidization technology to process the various nutrients in the multivitamin mineral powder into nanoemulsions, and then uses spray drying technology to prepare microcapsule powders. The microfluidization technology significantly improves the stability and bioavailability of these key ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 The flowchart schematically shows the steps of the method for preparing the multivitamin mineral powder according to the present invention. DETAILED DESCRIPTION

[0051] The multivitamin mineral powder and the preparation method thereof of the present invention will be further explained and illustrated below in conjunction with specific embodiments and the accompanying drawings. However, such explanation and illustration do not constitute an undue limitation to the technical solution of the present invention.

[0052] Examples 1-6

[0053] Figure 1 The flowchart schematically shows the steps of the method for preparing the multivitamin mineral powder according to the present invention.

[0054] like Figure 1 As shown, the multivitamin mineral powder of Examples 1-6 can be prepared based on the following steps:

[0055] 100: Prepare the oil phase raw materials according to the component design according to the following Table 1-1, and heat the oil phase raw materials at 40-80°C. Prepare the water phase raw materials according to the component design according to the following Table 1-2, heat the water phase raw materials at 40-80°C, and fully and evenly mix the heated oil phase and water phase;

[0056] 200: subjecting the oil phase raw material and the water phase raw material mixed in step 100 to high-speed shear emulsification to be fully dispersed to obtain a mixed emulsion, wherein the shear emulsification temperature is 40-60° C., the shear emulsification time is 5-10 minutes, and the shear emulsification speed is 11000-18000 r / min;

[0057] 300: Use an ultra-high pressure microfluidizer to homogenize the mixed emulsion at a pressure of 200-600 bar for 1-3 times, and then homogenize the mixed emulsion again at a pressure of 200-800 bar for 1-2 times;

[0058] 400: The homogenized mixed emulsion is mixed with microcrystalline cellulose. Microcrystalline cellulose, as a dry powder matrix, not only helps improve the fluidity and stability of the final product but also serves as a carrier for the active ingredient, facilitating its uniform dispersion. The homogenized mixed emulsion is then spray-dried using a spray dryer to obtain a multivitamin mineral powder. The finished multivitamin mineral powder compositions of Examples 1-6 are listed in Table 3. The spray dryer inlet air temperature is 160-210°C, the spray dryer outlet air temperature is 60-110°C, and the spray dryer feed rate is 10-30 mL / min.

[0059] Table 1-1. Oil phase raw materials (wt.%)

[0060]

[0061] Table 1-2. Aqueous phase raw materials (wt.%)

[0062]

[0063]

[0064] It should be noted that the total mass percentage of the oil phase raw materials and the water phase raw materials in Table 1-1 and Table 1-2 is 1.

[0065] The following Tables 2-1 and 2-2 list the specific process parameters of the multivitamin mineral powder of Examples 1-6 in the above process steps.

[0066] Table 2-1.

[0067]

[0068] Table 2-2.

[0069]

[0070]

[0071] Table 3 below lists the final composition of the multivitamin and mineral powder of Examples 1-6 after the above process steps.

[0072] Table 3.

[0073]

[0074] It should be noted that the additives in Table 3 refer to the sum of acidity regulators, sweeteners, emulsifiers, antibacterial agents, and flavors.

[0075] In order to verify the effect of the present invention, the content of the active ingredient in the multivitamin mineral powder prepared in Examples 1-6 was measured, wherein:

[0076] D-α-tocopherol content was determined using GB 1886.233-2016;

[0077] The content of calcium hydrogen phosphate is determined according to GB 1886.3-2021 and is calculated as CaHPO.

[0078] The magnesium oxide content is determined according to GB 1886.216-2016 and is calculated based on the content after ignition.

[0079] Potassium chloride content is determined according to GB 25585 and is calculated based on the content after ignition;

[0080] The content of ferrous gluconate was determined according to GB1903.10 and the content was calculated as trivalent iron;

[0081] The content of calcium citrate is determined according to GB1903.14 and the content is calculated on a dry basis;

[0082] The content of magnesium gluconate is determined according to GB1903.29 and the content is calculated on a dry basis;

[0083] The content of potassium dihydrogen phosphate is determined according to GB1886.333 and is expressed as Ca;

[0084] The ferrous sulfate content is determined according to GB29211 and is calculated as ferrous sulfate;

[0085] The content of calcium acetate is determined according to GB1903.15 and the content is calculated on anhydrous basis;

[0086] The magnesium carbonate content is determined according to GB25587 and is calculated based on the content after ignition;

[0087] The potassium citrate content is determined according to GB1886.74 and is calculated on a dry basis;

[0088] The ferric citrate content is determined according to GB1903.37 and is calculated on a dry basis;

[0089] The fish oil content was determined according to GB1903.26 and was calculated as triglycerides.

[0090] The physical and chemical indicators of the composite vitamin and mineral powder prepared in Examples 1-6 were measured. The test indicators and standards are shown in Table 4.

[0091] Table 4. Physical and chemical indexes of the multivitamin mineral powder prepared in Examples 1-6

[0092]

[0093] The corresponding test results of Examples 1-6 tested according to the above method are shown in Tables 5-1 to 5-6, respectively. Among them, the labeled value range of minerals is 75-125%, and the labeled value range of vitamins is 80-180%.

[0094] Table 5-1. Test results of Example 1

[0095]

[0096]

[0097] Table 5-2. Test results of Example 2

[0098]

[0099]

[0100] Table 5-3. Test results of Example 3

[0101]

[0102]

[0103] Table 5-4. Test results of Example 4

[0104]

[0105] Table 5-5. Test results of Example 5

[0106]

[0107]

[0108] Table 5-6. Test results of Example 6

[0109]

[0110]

[0111] It can be seen that the complex vitamin and mineral powder prepared by the present invention exhibits excellent stability and microbial stability after being placed for 1, 2, and 3 months. The active ingredient content, microbial content, and sedimentation volume ratio of the complex vitamin and mineral powder all meet the requirements of the present invention. The complex vitamin and mineral powder prepared by the present invention is suitable for oral administration, and not only performs well in the anti-hair loss effect, but also has significantly improved ingredient stability and bioavailability, meeting the market's urgent demand for efficient and safe anti-hair loss products.

[0112] It should be noted that the combination of the various technical features in this case is not limited to the combination described in the claims of this case or the combination described in the specific embodiments. All technical features recorded in this case can be freely combined or combined in any way unless there is a contradiction between them.

[0113] It should also be noted that the embodiments listed above are merely specific embodiments of the present invention. Obviously, the present invention is not limited to the above embodiments, and similar changes or modifications made therefrom that can be directly derived from or easily conceived by those skilled in the art based on the disclosure of the present invention are intended to fall within the scope of protection of the present invention.

Claims

1. A multivitamin mineral powder, characterized in that: Its active ingredients include:

2. The multivitamin mineral powder according to claim 1, wherein The mass percentage of each component is:

3. The multivitamin mineral powder according to claim 1 or 2, characterized in that The vitamin E is selected from D-α-tocopherol.

4. The multivitamin mineral powder according to claim 1 or 2, characterized in that The oil phase solvent includes at least one of medium chain triglycerides and olive oil.

5. The multivitamin mineral powder according to claim 1 or 2, characterized in that The mineral composition includes an Fe-containing component, a Mg-containing component, a Ca-containing component, and a K-containing component.

6. The multivitamin mineral powder according to claim 5, characterized in that: The Fe-containing component is selected from at least one of ferrous gluconate, ferrous sulfate, and ferric citrate; The Mg-containing component is selected from at least one of magnesium oxide, magnesium gluconate, and magnesium carbonate; The calcium-containing component is selected from at least one of: calcium hydrogen phosphate, calcium citrate, and calcium acetate; The K-containing component is selected from at least one of potassium chloride, dipotassium hydrogen phosphate, and potassium citrate.

7. The multivitamin mineral powder according to claim 6, characterized in that When the following components are contained, their contents satisfy at least one of the following conditions: Calcium hydrogen phosphate 1.15-2.05wt%; Magnesium oxide 1.15-2.15wt%; Potassium chloride 1.15-2.3wt%; Calcium citrate 1.3-2.15wt%; Magnesium gluconate 1.4-2.3wt%; Dipotassium hydrogen phosphate 1.55-2.4wt%; Calcium acetate 1.75-2.4wt%; Magnesium carbonate 1.75-1.95wt%; Potassium citrate 1.75-2.05wt%.

8. The multivitamin mineral powder according to claim 2, wherein The additives include at least one of an acidity regulator, a sweetener, an emulsifier, an antibacterial agent, and a flavor.

9. The method for preparing the multivitamin mineral powder according to any one of claims 1 to 8, characterized in that: Including steps: 100: Mix the oil phase raw materials and the water phase raw materials evenly; 200: Perform high-speed shear emulsification treatment to obtain a mixed emulsion; 300: performing ultra-high pressure microfluidization homogenization treatment on the mixed emulsion to obtain a homogenized mixed emulsion; 400: The homogenized mixed emulsion is mixed with a dry powder matrix, and then dried to obtain a multivitamin mineral powder.

10. The preparation method according to claim 9, wherein: The oil phase raw materials include: Vitamin E 0.12-0.36wt%; Fish oil 11.9-60wt%; Oil phase solvent 0-9wt%; The aqueous phase raw materials include: Mineral composition 3.6-7.2 wt%; Additives and water balance.

11. The preparation method according to claim 9, wherein In step 200, the temperature of the high-speed shear emulsification treatment is 40-60°C, the treatment time is 5-10 minutes, and the rotation speed of the high-speed shear emulsification is 11000 rpm-18000 rpm.

12. The preparation method according to claim 9, wherein In step 300, an ultra-high pressure microfluidizer is used to homogenize the mixture at a pressure of 200 to 600 bar for 1 to 3 times, and then at a pressure of 200 to 800 bar for 1 to 2 times.

13. The preparation method according to claim 9, wherein In step 400, the drying process adopts a spray drying process, wherein the inlet air temperature of the spray dryer is 160-210°C, the outlet air temperature of the spray dryer is 60-110°C, and the feed rate of the spray dryer is 10-30 mL / min.

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