Weight-losing composition as well as preparation method and application thereof

Abstract

The invention discloses a weight-losing composition as well as a preparation method and application thereof. The weight-losing composition comprises the following components in parts by weight: 1-10 parts of chia seed powder; 1-10 parts of sesame powder; 1-10 parts of roxburgh rose powder; 1 to 10 parts of grapefruit powder; 1-10 parts of mung bean powder; 10 to 30 parts of aloperine; 550 to 750 parts of fructus cannabis oil; 450 to 550 parts of sucrose polyester; and 450-550 parts of an auxiliary material. The weight-losing composition effectively controls synthesis, metabolism and absorption of fat in the body through multiple mechanisms, and has the advantages of being good in safety and compliance and capable of being used for a long time. The weight losing and health management system is beneficial to weight losing, can improve the overall health and reduce the risk of obesity-related diseases, and is an ideal and sustainable weight losing and health management scheme.

Description

Technical Field

[0001] The present invention relates to the fields of food and health products, and in particular to a weight loss composition, a preparation method and an application thereof. Background Art

[0002] As people's lifestyles and dietary habits change, the incidence of obesity is increasing year by year. Obesity is a contributing factor to numerous diseases, not only affecting a person's appearance and self-esteem but also closely linked to a variety of chronic conditions such as type 2 diabetes, hypertension, and cardiovascular disease. Obese individuals who experience chronic low-grade inflammation are susceptible to cancer and metabolic diseases. Therefore, obesity control is a crucial measure for maintaining national health. Excessive intake of high-fat, high-calorie foods combined with a lack of exercise leads to fat accumulation in the body, causing metabolic disorders and ultimately obesity.

[0003] Existing weight loss methods have the following drawbacks: 1. Surgery: While surgical weight loss procedures such as gastric bypass and gastric banding can significantly reduce weight in the short term, they are expensive and can cause life-threatening complications, making their safety and long-term effectiveness difficult to guarantee. 2. Exercise: While exercise is one of the healthiest ways to lose weight, it also carries side effects, such as potential injuries and problems with joints, muscles, and bones. Obese individuals have poor exercise capacity and are prone to symptoms like intolerance and shortness of breath, which limits the sustainability of their weight loss results. 3. Dieting: Reducing caloric intake to lose weight is also an effective method, but long-term dieting can lead to malnutrition, vitamin and mineral deficiencies, hunger, and increased appetite. Once a normal diet is resumed, weight regain is likely to occur, creating a vicious cycle. 4. Weight loss pills and teas: Popular weight loss pills and teas currently on the market work by suppressing appetite, accelerating metabolism, or preventing fat absorption. Common side effects include gastrointestinal discomfort, irregular heartbeats, and neurological damage.

[0004] The present invention aims to provide a safe, effective and user-compliant weight loss method derived from natural products. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the present invention provides a weight loss composition, a preparation method thereof, and an application thereof. The weight loss composition of the present invention promotes fat excretion and inhibits fat accumulation in the body through the synergistic effect of multiple active ingredients, thereby achieving a weight loss effect.

[0006] The present invention provides a weight loss composition, which comprises the following components, in parts by weight: 1 to 10 parts of chia seed powder, preferably 3 to 8 parts; 1 to 10 parts of sesame powder, preferably 3 to 8 parts; 1 to 10 parts of sea buckthorn powder, preferably 3 to 8 parts; 1 to 10 parts of grapefruit powder, preferably 3 to 8 parts; 1 to 10 parts of mung bean powder, preferably 3 to 8 parts; and 10 to 30 parts of alopecurine, preferably 15 to 25 parts.

[0007] 550-750 parts of hemp seed oil, preferably 600-700 parts; 450-550 parts of sucrose polyester, preferably 480-530 parts; 450-550 parts of auxiliary materials, preferably 480-530 parts.

[0008] In some embodiments, the purity of alopecurine is ≥90%.

[0009] In some embodiments, the antioxidant activity of alopecurine is ≥ 100 μmol Trolox equivalent / 100 mg.

[0010] In some embodiments, the chia seed powder and sesame powder have a mass ratio of 1.5:(1-2); the chia seed powder is primarily used to increase satiety and improve fat metabolism, while the sesame powder can increase antioxidant effects and promote fat decomposition. The combination of the two helps prolong satiety and enhance weight loss.

[0011] In some embodiments, the compounding ratio of mung bean powder to alopecurine is 1:(3-8), preferably 1:(4-6).

[0012] Mung bean flour, rich in dietary fiber and antioxidants, helps eliminate waste from the body and promotes efficient fat metabolism. Sophora flavescens further enhances fat breakdown by stimulating fatty acid oxidation and reducing fat synthesis. The combination of these two enhances fat metabolism. Mung bean flour regulates intestinal function and reduces fat absorption, complementing Sophora flavescens's ability to inhibit fat synthesis, thereby helping to reduce abdominal fat accumulation and optimize fat distribution.

[0013] At high doses, alopecurine can easily disrupt the balance of intestinal flora, affecting the health of the digestive system and the weight loss effect. Excessive mung bean powder can easily lead to impaired absorption of fat-soluble nutrients, which in turn reduces the weight loss effect. By adjusting the compounding ratio of mung bean powder and alopecurine, the present invention can balance the irritation of the metabolic acceleration brought by alopecurine with the fiber and antioxidant effects of mung bean powder. This can ensure that the weight loss composition reduces fat accumulation while not causing metabolic disorders or negative effects in the body, achieving a more balanced and sustained weight loss effect.

[0014] The weight-loss composition of the present invention is in the form of a unit dosage for oral administration.

[0015] In some embodiments, the auxiliary material is one or more auxiliary materials acceptable to the food industry. The selection of auxiliary materials should ensure product stability, taste and extended shelf life. The proportion of sucrose polyester should ensure that it can effectively replace part of the fat without affecting the overall calorie control.

[0016] In some embodiments, the auxiliary material is one or more of edible gum, purified water, glycerin, purified water, oil, pigment, and sugar.

[0017] In some embodiments, the edible gum is one or more of gelatin, gum arabic, and pectin.

[0018] In some embodiments, the oil is one or more of soybean lecithin and vitamin E.

[0019] In some embodiments, the pigment is one or more of caramel color and sunset yellow;

[0020] The sugar is one or more of xylitol, steviol glycoside and aspartame.

[0021] The present invention provides a preparation of a weight-loss composition, comprising the weight-loss composition.

[0022] In some embodiments, the formulation is a powder, granules, capsule or tablet.

[0023] In order to prepare the dosage form into tablets, various carriers well known in the art can be widely used. Examples of carriers are as follows: diluents and absorbents, such as starch, dextrin, calcium sulfate, lactose, mannitol, sucrose, sodium chloride, glucose, urea, calcium carbonate, kaolin, microcrystalline cellulose, aluminum silicate, etc.; wetting agents and binders, such as water, glycerol, polyethylene glycol, ethanol, propanol, starch slurry, dextrin, syrup, honey, glucose solution, acacia slurry, gelatin slurry, sodium methylcellulose, shellac, methylcellulose, potassium phosphate, polyvinyl pyrrolidone, etc.; disintegrants, such as dry starch, alginate, agar powder, brown algae starch, sodium bicarbonate and citric acid, calcium carbonate, polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, methylcellulose, ethylcellulose, etc.; disintegration inhibitors, such as sucrose, tristearin, cocoa butter, hydrogenated oil, etc.; absorption accelerators, such as quaternary ammonium salts, sodium lauryl sulfate, etc.; lubricants, such as talc, silicon dioxide, corn starch, stearate, boric acid, liquid paraffin, polyethylene glycol, etc. The tablets can be further made into coated tablets, such as sugar-coated tablets, film-coated tablets, enteric-coated tablets, or double-layer tablets and multi-layer tablets.

[0024] The dosage of the weight-loss composition of the present invention depends on many factors, such as the nature and severity of the obesity to be prevented or treated, the sex, age, weight, personality, and individual response of the subject or animal, the route of administration, and the frequency of administration. Therefore, the dosage range of the present invention allows for considerable variation. The dosage range of the present invention can be appropriately adjusted based on the actual amount of active drug in the final formulation of the pharmaceutical composition of the present invention to achieve the therapeutically effective amount required to achieve the therapeutic purpose of the present invention.

[0025] The present invention provides a method for preparing the weight loss composition, comprising the following steps:

[0026] S1: Chia seed powder, sesame powder, sea pear powder, grapefruit powder, and mung bean powder were weighed separately and filtered through a sieve to remove any particulate matter, mixed, and alopecurine and excipients were added to obtain mixture 1;

[0027] S2: Mix hemp seed oil and sucrose polyester, add into the mixture 1 described in S1, and use a high shear mixer to uniformly mix all the components to obtain the weight loss composition.

[0028] The present invention provides an application of the weight-loss composition in preparing weight-loss foods, medicines and / or health products.

[0029] In summary, compared with the prior art, the present invention achieves the following technical effects:

[0030] 1. The active ingredients in the composition of the present invention can inhibit the synthesis of triglycerides by regulating the activity of enzymes related to fat metabolism in the body. Triglycerides are the most important form of fat in the body, and their synthesis process is regulated by multiple enzymes. The ingredients in the composition of the present invention, particularly alopecurine and mung bean powder, can reduce the synthesis of triglycerides by improving the fat metabolism pathway, thereby effectively controlling fat accumulation in the body and reducing obesity.

[0031] 2. The mung bean flour and sucrose polyester in the composition of the present invention can reduce fat absorption in the intestines, thereby reducing fat entry into the body. The dietary fiber and antioxidants in mung bean flour can reduce fat absorption, lower blood lipid levels, prevent excessive fat accumulation, and help regulate body weight. Sucrose polyester, as a natural food ingredient, has excellent fat absorption properties, helping to reduce dietary fat absorption.

[0032] 3. The composition of the present invention is made from food-grade raw materials, is non-toxic, has low side effects, and is suitable for long-term use. The selected raw materials, such as chia seed powder, sesame powder, and roxburghii powder, are all natural food ingredients with high nutritional value and health benefits. These ingredients can not only provide the necessary nutritional support during weight loss, but also have multiple biological activities that help maintain good health. In addition, the composition of the present invention does not cause side effects or dependence during long-term use, and can therefore be used as a long-term supplement for daily health management.

[0033] 4. The weight loss composition of the present invention effectively controls the synthesis and absorption of body fat through multiple mechanisms, which not only helps to lose weight, but also improves overall health and reduces the risk of obesity-related diseases. It is an ideal and sustainable weight loss and health management program. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0035] Figure 1 This is the triglyceride content test result of Test Example 1 of the present invention;

[0036] Figure 2 This is the LPS activity test result of Test Example 2 of the present invention;

[0037] Figure 3 This is the hematoxylin-eosin staining result of Test Example 3 of the present invention;

[0038] Figure 4 The statistical results of the mouse weight in Test Example 4 of the present invention are as follows;

[0039] Figure 5 This is the hematoxylin-eosin staining result of mouse liver tissue in Test Example 4 of the present invention;

[0040] Figure 6 These are the test results of mouse serum indicators in Test Example 4 of the present invention. DETAILED DESCRIPTION

[0041] To help those skilled in the art better understand the present invention, the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present invention.

[0042] Unless otherwise specified, the experimental methods used in the following examples are conventional methods. The materials and reagents used are all commercially available unless otherwise specified.

[0043] The preparation method of the weight loss composition of the present application is specifically as follows:

[0044] (1) Mixing powder components and alopecurine:

[0045] Chia seed powder, sesame powder, sea buckthorn powder, grapefruit powder, mung bean powder: Each powder raw material needs to be weighed and filtered through a 100 mesh (or finer) sieve to ensure that any particulate matter is removed and ensure the fineness and uniformity of the powder.

[0046] Sophora flavescens: Sophora flavescens with a purity of ≥95% was selected (purchased from Shanghai Yuanye Biotechnology Co., Ltd., product number S26744).

[0047] (2) In a Class 100,000 cleanroom, the screened powder components were mixed in proportion and initially mixed using a low-speed stirrer (100 rpm) for approximately 15 minutes to ensure uniform mixing of the powders. The dissolved alopecurine and excipients were then added to the mixed powder components and mixed using a medium-speed stirrer (200 rpm) for approximately 20 minutes to ensure uniform distribution of alopecurine in the powders and achieve full fusion.

[0048] (3) Hemp seed oil is heated to 50° C. to maintain fluidity and facilitate mixing with sucrose polyester, and the mixture obtained in step (1) is added thereto. The mixture is mixed using a high shear mixer, wherein the operating parameters of the high shear mixer are set to a rotation speed of 2000 rpm.

[0049] (4) Drying: Use a vacuum drying oven for drying. The drying temperature is controlled at 50°C and the drying time is 40 minutes to ensure that the raw materials are completely dried without affecting the active ingredients.

[0050] (5) Add 2% of the total weight of hydroxypropyl methylcellulose (HPMC) as a binder and prepare wet granules by wet granulation. The size of the wet granules is controlled to be 20-40 mesh to ensure the uniformity of the granules.

[0051] (6) Dry the wet granules in a hot air drying oven at a temperature of 50-60°C until the moisture content of the granules drops below 10%.

[0052] (7) Prepare a tablet press. Place the dried granules into the tablet press and compress them into tablets weighing 500 mg using high pressure molding. The pressure is controlled between 10 and 30 kN to ensure tablet density and hardness.

[0053] (8) Dry the newly pressed tablets to ensure that the moisture content is below 5%. The drying temperature is controlled at 40-50°C.

[0054] It should be noted that the weight loss composition of the present invention can be prepared not only into tablets, but also into other oral dosage forms such as powders, granules and capsules.

[0055] Example 1

[0056] The weight loss composition of this embodiment has the following components: 1 part chia seed powder, 1 part sesame powder, 1 part sea buckthorn powder, 1 part grapefruit powder, 1 part mung bean powder, 10 parts of alopecurine, 550 parts of hemp seed oil, 450 parts of sucrose polyester, 300 parts of gelatin, 120 parts of glycerin, 10 parts of soybean lecithin, 10 parts of xylitol, and 10 parts of caramel color.

[0057] Example 2

[0058] The weight loss composition of this embodiment has the following components: 10 parts of chia seed powder, 10 parts of sesame powder, 10 parts of sea buckthorn powder, 10 parts of grapefruit powder, 10 parts of mung bean powder, 30 parts of alopecurine, 750 parts of hemp seed oil, 550 parts of sucrose polyester, 360 parts of gelatin, 150 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0059] Example 3

[0060] The weight loss composition of this embodiment has the following components: 6 parts of chia seed powder, 8 parts of sesame powder, 8 parts of sea buckthorn powder, 8 parts of grapefruit powder, 8 parts of mung bean powder, 25 parts of alopecurine, 700 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0061] Example 4

[0062] The weight loss composition of this embodiment has the following components: 4.5 parts of chia seed powder, 3 parts of sesame powder, 5 parts of sea buckthorn powder, 5 parts of grapefruit powder, 10 parts of mung bean powder, 25 parts of alopecurine, 600 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0063] Example 5

[0064] The weight loss composition of this embodiment has the following components: 4.5 parts of chia seed powder, 3 parts of sesame powder, 5 parts of sea buckthorn powder, 5 parts of grapefruit powder, 5 parts of mung bean powder, 30 parts of alopecurine, 600 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0065] Comparative Example 1

[0066] The weight loss composition of this embodiment has the following components: 4.5 parts of chia seed powder, 3 parts of sesame powder, 5 parts of sea buckthorn powder, 5 parts of grapefruit powder, 5 parts of mung bean powder, 600 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0067] Comparative Example 2

[0068] The weight loss composition of this embodiment has the following components: 4.5 parts of chia seed powder, 3 parts of sesame powder, 5 parts of sea buckthorn powder, 5 parts of grapefruit powder, 5 parts of mung bean powder, 50 parts of alopecurine, 600 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0069] Comparative Example 3

[0070] The weight loss composition of this embodiment has the following components: 4.5 parts of chia seed powder, 3 parts of sesame powder, 5 parts of sea buckthorn powder, 5 parts of grapefruit powder, 20 parts of mung bean powder, 30 parts of alopecurine, 600 parts of hemp seed oil, 500 parts of sucrose polyester, 330 parts of gelatin, 130 parts of glycerin, 10 parts of soybean lecithin, 15 parts of xylitol, and 15 parts of caramel color.

[0071] Test Example 1 Effect of the Weight Loss Composition on Triglyceride (TG) Synthesis Capacity.

[0072] The effect of the weight loss composition of the present invention on triglyceride (TG) synthesis capacity was measured. Triglyceride is the main component of fat. Reducing fat synthesis can effectively reduce body weight. The specific steps are:

[0073] MC3T3 cells were added to DMEM medium, a mixture containing 10% serum and 100 units of double-antibody was added, and then cultured in a 37°C carbon dioxide incubator overnight. The cell concentration was adjusted to 1×10 5 Cells were plated in a 96-well plate, 100 μL of cell suspension was added to each well, and then the compositions prepared in Examples 1 to 5 and Comparative Examples 1 to 3 were added to a final concentration of 50 μg / mL. One day after cell plating, triglyceride content was detected using a TG kit.

[0074] The results are as follows Figure 1 As shown, Examples 1-5 can significantly reduce the synthesis of TG, while Comparative Examples 1-3 are less effective in reducing TG than Examples 1-5.

[0075] Test Example 2 Effect of the Weight Loss Composition on the Activity of Lipase (LPS) in Hydrolyzing Fat

[0076] The decrease in lipase hydrolysis activity can reduce the absorption of fat by intestinal tissue. The specific testing method includes the following steps:

[0077] (1) Weigh 4 mg of sucrase, dissolve it in 4 mL of PBS, and store it at 4°C until ready for use.

[0078] (2) The preparations prepared in Examples 1 to 5 and Comparative Examples 1 to 3 were respectively prepared into solutions with a raw material concentration of 100 μg / mL.

[0079] (3) 1 mL of each of the solutions in (1) and (2) was mixed, and then tested using an LPS activity kit. The absorbance was read at a wavelength of 580 nm, and the effect of the LPS activity of the example was calculated.

[0080] The results are as follows Figure 2 As shown, Examples 1 to 5 can significantly reduce LPS enzyme activity, while the differences in Comparative Examples 1 to 3 are not significant, indicating that the composition of the present invention can reduce lipid absorption.

[0081] Test Example 3 Effect of Weight Loss Composition on Fat Generation

[0082] This example tests the effect of the composition of the present invention on adipogenesis, and the specific steps are as follows:

[0083] MC3T3 cells were added to DMEM medium, 10% serum and 100 units of double antibody, and then cultured in a carbon dioxide incubator at 37°C overnight. The cell concentration was adjusted to 1×10 5 / mL, plated in a 96-well plate, and added with Examples 1 to 5 and Comparative Examples 1 to 3 to a final concentration of 50 μg / mL. After 1 day, the supernatant was removed, fixed with paraformaldehyde, and then stained using a hematoxylin-eosin staining kit.

[0084] The results are as follows Figure 3 As shown, compared with the model group, the fat content in the cells treated with Examples 1 to 5 was reduced to varying degrees, while the treatment with Comparative Examples 1 to 3 had little effect on fat.

[0085] Test Example 4 Effect of the Weight Loss Composition on Mouse Body Weight

[0086] Five-month-old male C57BL / 6 mice were used and divided into a blank group and other groups. The blank group used a regular diet, while the other groups were adaptively fed with a high-fat diet for 1 week.

[0087] The mice with the slowest weight gain in other groups were removed, and the remaining mice were randomly divided into a model group, a positive drug group (orlistat), and a test group (Examples 1 to 5 and Comparative Examples 1 to 3).

[0088] The blank group used regular feed, and the model group, positive drug group, and test group were fed with high-fat feed. The blank group and model group were gavaged with distilled water, the positive drug was gavaged at 20 mg / kg, and the test group was gavaged at 10 mg / kg, twice a day. The mice were raised for 3 weeks, the status of the mice was observed every day, and the weight was weighed every week and the data was recorded. After the experiment, blood was collected from the orbits and centrifuged to obtain serum. The levels of TG, TC, HDL-C, and LDL-C were detected using a kit. The liver tissue of the mice was taken, paraffin sections were made, and stained with hematoxylin-eosin.

[0089] like Figure 4 As shown, the compositions of Examples 1-5 significantly reduced the body weight of the mice in the experimental groups, significantly outperforming the active drug, while the effects of Comparative Examples 1-3 were less pronounced than those of the active drug. Furthermore, starting from the second week, the body weight of the mice given the compositions of Examples 1-5 was essentially controlled. Daily observations showed that the mice in each group were in excellent condition, with no toxic reactions, demonstrating low toxicity.

[0090] Figure 5 The results showed that HE staining of the livers of mice treated with Examples 1 to 5 showed a significant decrease in liver fat content compared to the model group. However, the liver fat content of mice treated with Comparative Examples 1 to 3 showed no significant difference compared to the model group, indicating that the compositions of Comparative Examples 1 to 3 were ineffective in improving liver fat deposition.

[0091] Figure 6 The results showed that the serum index test results of the mice given Examples 1 to 5 showed a significant decrease in fat-related indicators, indicating that taking Examples 1 to 5 can effectively improve lipid metabolism and reduce body fat content. However, there was no significant difference in the relevant indicators of Comparative Examples 1 to 3, indicating that the compositions of Comparative Examples 1 to 3 were not effective in improving lipid metabolism and reducing fat content.

[0092] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A weight loss composition, characterized in that In parts by weight, it comprises the following components:

2. The weight loss composition according to claim 1, characterized in that The mass ratio of the mung bean powder to alopecurine is 1:(3-8).

3. The weight loss composition according to claim 1, characterized in that The auxiliary material is one or more auxiliary materials acceptable to food.

4. The weight loss composition according to claim 4, characterized in that The auxiliary materials are one or more of edible glue, purified water, glycerin, purified water, oil, pigment, and sugar.

5. The weight loss composition according to claim 4, characterized in that The edible gum is one or more of gelatin, gum arabic and pectin.

6. The weight loss composition according to claim 4, characterized in that The oil is one or more of soybean lecithin and vitamin E.

7. The weight loss composition according to claim 4, characterized in that The pigment is one or more of caramel color and sunset yellow; The sugar is one or more of xylitol, steviol glycoside and aspartame.

8. A preparation of a weight loss composition, characterized in that: The slimming composition comprises the slimming composition according to any one of claims 1 to 7.

9. The method for preparing the weight loss composition according to any one of claims 1 to 7, characterized in that: The steps include: S1: Chia seed powder, sesame powder, sea pear powder, grapefruit powder, and mung bean powder were weighed separately and filtered through a sieve to remove any particulate matter, mixed, and alopecurine and excipients were added to obtain mixture 1; S2: Mix hemp seed oil and sucrose polyester, add into the mixture 1 described in S1, and use a high shear mixer to uniformly mix all the components to obtain the weight loss composition.

10. Use of the weight-loss composition according to any one of claims 1 to 7 in the preparation of weight-loss foods, medicines and / or health products.

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