Novel caries-preventing and tooth-decay-preventing formula

Abstract

The invention relates to the technical field of cosmetic toothpaste, in particular to a novel anti-decayed tooth formula, which comprises a raw material bag using auxiliary materials, and the raw material bag comprises a sodium fluoride raw material and a decetaxel raw material. The content of the sodium fluoride raw material is 0.05%-0.25%, and the content of the diclatafluorine raw material is 0.2%-3%. A toothpaste finished product B is obtained when the content of the sodium fluoride raw material is 0.1%-0.2% and the content of the diclatafluorine raw material is 0.5%-2.5%, and a toothpaste finished product C is obtained when the content of the sodium fluoride raw material is 0.15%-0.18% and the content of the diclatafluorine raw material is 1.5%-2%. According to the invention, the sodium fluoride raw material and the diclatasol raw material in a specified ratio are added into the toothpaste body to form a fluorine-containing compound, so that the overall activity of the toothpaste body is relatively high, and the fluorine-containing compound with the determined ratio can effectively protect teeth by comparing use results according to different fluorine contents.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetic toothpaste, in particular to a novel anti-caries and anti-tooth decay formula. Background Art

[0002] Toothpaste is a product that protects dental health. Because food residues left in the mouth by people, lactic acid bacteria convert the calcium in the enamel on the surface of the teeth into soluble calcium lactate, causing grooves and holes in the teeth and forming caries. Therefore, it is necessary to brush your teeth frequently and use toothpaste to remove residual food and tartar. Cosmetic toothpaste units are produced in accordance with the national standards GB / T8372 and QB / T2966.

[0003] Fluoride raw materials are added to the toothpaste formula, and the fluoride ion content for children is 0.05%-0.11%, and for adults it is 0.05%-0.15%. According to national standards, it is considered to have the effect of preventing caries and tooth decay. Currently, the raw materials for adding fluoride ingredients on the market are basically sodium fluoride and sodium monofluorophosphate, which protect the tooth surface through chemical reactions. The disadvantage of these two types of raw materials is that their activity is relatively low. When the activity of sodium fluoride and sodium monofluorophosphate is low, the caries prevention effect, acid resistance, remineralization effect, oral cleaning ability, teeth whitening, relief of tooth sensitivity, and strengthening of enamel are all affected. When facing the acidic substances produced by the fermentation of food residues in the mouth, teeth are more susceptible to erosion and the risk of demineralization increases, thereby greatly reducing the effect of preventing caries. Summary of the Invention

[0004] The purpose of the present invention is to solve the problem of low activity of toothpaste in the prior art and to propose a new anti-caries and anti-tooth decay formula.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A novel anti-caries and anti-tooth decay formula comprises a raw material package using auxiliary materials, wherein the raw material package comprises sodium fluoride raw material and diketafur raw material.

[0007] Preferably, the content of the sodium fluoride raw material is 0.05%-0.25%, and the content of the diketafur raw material is 0.2%-3% to obtain the toothpaste finished product A.

[0008] Preferably, the content of the sodium fluoride raw material is 0.1%-0.2%, and the content of the diketafur raw material is 0.5%-2.5% to obtain the toothpaste product B.

[0009] Preferably, the content of the sodium fluoride raw material is 0.15%-0.18%, and the content of the diketafur raw material is 1.5%-2% to obtain the toothpaste finished product C.

[0010] Preferably, the formulation comprises the following steps:

[0011] Step S1, preparing materials: Step S1, preparing materials refers to preparing auxiliary materials, sodium fluoride raw materials, and diketafur raw materials;

[0012] Step S2, proportioning and weighing;

[0013] Step S3, raw material pretreatment;

[0014] Step S4, paste processing group.

[0015] Preferably, the weighing and proportioning refer to scientific proportioning according to the differences of auxiliary materials, sodium fluoride raw materials and diketafur raw materials, and using weighing equipment to accurately weigh the proportioned auxiliary materials, sodium fluoride raw materials and diketafur raw materials.

[0016] Preferably, the raw material pretreatment includes a dissolution treatment;

[0017] The dissolving process refers to adding the sodium fluoride raw material and the diketafur raw material into the liquid raw material for pre-mixing.

[0018] Preferably, the paste processing group includes a mixing module, a color adjustment module, a flavoring module, a filling module, a packaging module, and a detection module.

[0019] Preferably, the mixing module is to put the auxiliary materials, sodium fluoride raw material, and diketafur raw material into a stirring device for thorough mixing;

[0020] The color adjustment module is to drop the pigment into the mixed paste to make the paste reach the desired color;

[0021] The flavoring module is used to add sweeteners and spices into the mixed paste to adjust the taste of the paste;

[0022] The filling module is to fill the prepared paste into a toothpaste tube or a light-proof container through a filling device;

[0023] The packaging module is to package the filled toothpaste and affix labels with the product name, ingredients, and usage information;

[0024] The detection module is used to detect the fluorine content, diketafur, pH value, stability and microbial indicators in the paste.

[0025] Compared with the prior art, the present invention has the following advantages:

[0026] 1. The present invention adds sodium fluoride raw materials in a specified ratio into the paste. The sodium fluoride raw materials react with hydroxyapatite in the teeth to form fluorapatite that is more insoluble in acid, thereby enhancing the acid resistance of tooth enamel, making teeth more resistant to acidic substances in food, helping to reduce the erosion of teeth by acidic substances, and thus reducing the risk of tooth decay.

[0027] 2. The present invention adds a diketafiorate raw material in a specified ratio into the paste. The diketafiorate can combine with the minerals on the surface of the teeth to form a more acid-resistant fluoride layer. This fluoride layer can resist the erosion of acidic substances in the mouth, reduce the risk of tooth demineralization, and thus effectively prevent the occurrence of caries. The diketafiorate raw material has good fluoride release ability and ductility, can effectively wrap the teeth and resist the acidic environment.

[0028] In summary, the present invention adds a specified ratio of sodium fluoride raw material and diketafur raw material into the toothpaste to form a fluorine-containing compound, which makes the overall activity of the paste relatively high. By comparing the usage results according to different fluorine contents, the fluorine-containing compound with a determined ratio can effectively protect teeth. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 A schematic diagram of the preparation steps of a novel anti-caries and anti-tooth decay formula proposed in the present invention;

[0030] Figure 2 This is a schematic diagram of the raw material pretreatment of a new type of anti-caries and anti-tooth decay formula proposed in the present invention;

[0031] Figure 3 The invention provides a new paste processing group for preventing tooth decay and tooth decay. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0033] Reference Figure 1-Figure 3 , a new type of anti-caries and anti-tooth decay formula, including a raw material package using auxiliary materials, the raw material package includes sodium fluoride raw material and diketafur raw material. It is supplemented that by adding sodium fluoride raw material and diketafur raw material into the paste, the mechanism of action of sodium fluoride is that sodium fluoride can react with hydroxyapatite in teeth during oral care to generate more acid-resistant fluorapatite. Diketafur raw material is a fluorinated amine compound, which has more stable fluoride release ability and ductility than sodium fluoride, and can effectively wrap teeth and resist acidic environment.

[0034] It is further explained that the fluorine-containing compound formed by the sodium fluoride raw material and the diketafur raw material focuses on the formation of a physical protective layer. The fluorine-containing compound has a relatively high activity. Sodium fluoride enhances the acid resistance of tooth enamel through chemical replacement reaction, while diketafur forms a protective layer through physical covering. The dual combination of sodium fluoride raw material and diketafur raw material can achieve the following advantages:

[0035] 1. Enhance tooth enamel structure and acid erosion resistance;

[0036] 2. Inhibit the activity of cariogenic bacteria and biofilm formation;

[0037] 3. Relieve tooth sensitivity and repair micro-damage;

[0038] 4. Long-term caries prevention and oral environment regulation.

[0039] This formula uses the dual mechanisms of "mineral repair and antibacterial intervention" to take into account both immediate protection and long-term oral health maintenance. It is especially suitable for people with a high risk of caries, and the dosage for children needs to be strictly controlled.

[0040] First of all, it should be pointed out that the maximum safe daily fluoride intake for adults is 3.4 mg, and for children it is 1.9-2.1 mg.

[0041] The content of the sodium fluoride raw material is 0.05%-0.25%, and the content of the diketafur raw material is 0.2%-3% to obtain a toothpaste finished product A.

[0042] It is further pointed out that the toothpaste finished product A:

[0043]

[0044] Table 1

[0045] From Table 1 we can see that;

[0046] Time is positively correlated with effectiveness: Enamel strength and acid resistance increase exponentially with extended use. For example, acid resistance increases to 10 times its initial value within 42 days, demonstrating that long-term use is more effective in preventing caries. The 21st day is the critical point for effectiveness, with all indicators showing a significant acceleration in growth. Continued use for more than three weeks is recommended to maintain the effects.

[0047] Potential Relationship Between Raw Material Content and Effectiveness: Sodium fluoride content is relatively low (0.05%-0.25%), likely primarily contributing to a basic caries prevention effect. Diketafur content ranges widely (0.2%-3%), and its high concentration may be a key factor in strengthening enamel and improving acid resistance. However, further investigation is needed to determine the specific relationship between raw material ratios and effectiveness.

[0048] Clinical Significance: Over a 42-day period, the increased strength and acid resistance of tooth enamel can effectively reduce the incidence of dental caries, making it particularly suitable for populations at high risk of dental caries (such as children and those with poor oral hygiene). Early caries repair effects are evident after 21 days, suggesting that toothpaste can repair early enamel damage. Prompt use of this product is recommended at the first signs of early dental caries.

[0049] Extended Recommendations: Duration of Use: It is recommended to continue using for at least 42 days to achieve optimal preventive effects. Raw Material Optimization: Further research is needed to determine the upper limit of diketafur's effectiveness at a 3% concentration, as well as its synergistic effect with sodium fluoride.

[0050] Population segmentation: For special groups such as children or the elderly, the raw material content can be adjusted to balance effect and safety.

[0051] The content of the sodium fluoride raw material is 0.1%-0.2%, and the content of the diketafur raw material is 0.5%-2.5% to obtain a toothpaste product B.

[0052] It is further pointed out that the toothpaste product B:

[0053]

[0054]

[0055] Table 2

[0056] From Table 2, we can see that;

[0057] 7 days: The relief effect is more obvious (compared to the "initial relief" of finished product A), and the improvement of enamel strength is accelerated.

[0058] 21 days: Enamel strengthening and early caries repair (same as product A), but with a greater improvement in indicators.

[0059] 42 days: Significant caries prevention effect, added sensitivity relief effect, and higher level of enamel protection.

[0060] According to Tables 1 and 2, the sodium fluoride content is concentrated in the range of 0.1%-0.2%, and the lower limit of diketafur is increased to 0.5%, which may enhance the synergistic effect of the two.

[0061] For example: After the content of diketafur is increased, the enamel strength increases by about 30% after 21 days compared with finished product A, and the acid resistance increases by about 10%.

[0062] Lowering the upper limit of diketafur to 2.5% may reduce irritation while ensuring effectiveness, laying a solid foundation for sensitivity relief effects.

[0063] 21 days is still the watershed of effectiveness, but the indicators of toothpaste product B at this stage are close to the 42-day level of toothpaste product A, indicating that the "rapid effect period" has been shortened.

[0064] The content of the sodium fluoride raw material is 0.15%-0.18%, and the content of the diketafur raw material is 1.5%-2% to obtain a toothpaste finished product C.

[0065] It is further pointed out that the toothpaste product C:

[0066]

[0067]

[0068] Table 3

[0069] From Table 3 we can see that;

[0070] 7 days: The relief effect is the same as toothpaste product B, but the improvement in enamel indicators is greater.

[0071] 21 days: The effects of enamel strengthening and early caries repair were upgraded to "significant".

[0072] 42 days: The effects of caries prevention and sensitivity relief continued to strengthen, and the enamel protection index reached the highest value of the three.

[0073] Refining the raw material ratio can improve the upper limit of the effect:

[0074] The sodium fluoride content is concentrated in the range of 0.15% to 0.18%, and diketafur is increased to 1.5% to 2%, which may form a better synergistic effect.

[0075] For example: an increase of 0.5% in the diketafiorate content increased the enamel strength by about 33% and the acid resistance by about 11% after 21 days, and the raw material concentration range narrowed: this suggests that the production process may pay more attention to precise quantity control to maximize the efficiency of fluoride ion release.

[0076] The growth rate of effects and peak indexes reached new highs:

[0077] After 42 days, the enamel strength reached 40%-47%, and the acid resistance reached 60%, which were 17.5% and 7.1% higher than those of toothpaste product B, respectively. The sensitivity relief effect may be more thorough (because the improvement in these indicators is positively correlated with the concentration of diketafur). The acid resistance of 42% after 21 days was close to the 42-day level of toothpaste product A (50%), indicating that toothpaste product C can achieve the long-term effects of the traditional formula in the medium term.

[0078] Clinical applications are targeted at precise scenarios: it is suitable for people at high risk of dental caries (such as those with a high-sugar diet and insufficient saliva secretion) and patients with moderate to severe dentin sensitivity. Because its short-term indicators improve quickly and its long-term protection is stronger, the effect of early dental caries repair is "significant", which may shorten the clinical intervention cycle and reduce the need for fillings.

[0079] It is further pointed out that the toothpaste products A, B and C:

[0080]

[0081] Table 4

[0082] As shown in Table 4, the initial use of the paste can initially improve the strength of tooth enamel and the acid resistance of tooth enamel, and with long-term use, the strength of tooth enamel and the acid resistance of tooth enamel can prevent tooth decay and tooth decay. By regulating the content of sodium fluoride raw material and the content of diketafur raw material and comparing the test results after use, the precise ratio of sodium fluoride raw material and diketafur raw material can be further obtained.

[0083] Step S1, preparing materials: preparing materials refers to preparing auxiliary materials, sodium fluoride raw materials, and diketafur raw materials;

[0084] Step S2, proportioning and weighing;

[0085] Weighing and proportioning refer to scientific proportioning according to the differences of auxiliary materials, sodium fluoride raw materials, and diketafur raw materials, and the use of weighing equipment to accurately weigh the proportioned auxiliary materials, sodium fluoride raw materials, and diketafur raw materials. The fluoride content required by adults and children is different, and precise proportioning is required based on the different fluoride content, which can be targeted at people of different age groups.

[0086] Step S3, raw material pretreatment;

[0087] Raw material pretreatment includes melting treatment;

[0088] When stirring sodium fluoride, pay attention to controlling the temperature, pressure and other conditions to ensure that the sodium fluoride is fully integrated with the toothpaste base and that no chemical reaction occurs that affects the quality and performance of the toothpaste;

[0089] The dissolution treatment refers to pre-mixing the sodium fluoride raw material and the diketafur raw material into the liquid raw material respectively, and pre-mixing the diketafur raw material with a small amount of other liquid raw materials (such as some moisturizers) to prepare a uniform solution or suspension, so as to facilitate better dispersion in the entire toothpaste matrix later.

[0090] Step S4, paste processing group;

[0091] The paste processing group includes a mixing module, a color adjustment module, a flavoring module, a filling module, a packaging module, and a detection module.

[0092] The mixing module is to put the auxiliary materials, sodium fluoride raw materials, and diketafur raw materials into the stirring equipment for thorough mixing;

[0093] It further states:

[0094] Pre-mix the solid raw materials such as the friction agent and thickener to make them initially uniform, and mix the liquid raw materials such as the moisturizer and surfactant in another container.

[0095] The premixed solution of diketafur is gradually added to the other mixed liquid raw materials while stirring to ensure that the diketafur is evenly dispersed in the liquid system.

[0096] Under stirring, slowly add the premixed solid raw materials into the liquid mixture containing diketafur, and continue stirring and mixing to fully blend the various raw materials to form a uniform toothpaste matrix.

[0097] Use homogenizing equipment to homogenize the toothpaste base, and through high pressure, the various ingredients in the toothpaste are further refined and evenly distributed, thereby improving the stability and taste of the toothpaste.

[0098] The color adjustment module is to drop pigment into the mixed paste to make the paste reach the desired color;

[0099] The flavoring module is used to add sweeteners and spices into the mixed paste to adjust the taste of the paste;

[0100] The filling module is to put the prepared paste into the toothpaste tube or opaque container through the filling equipment;

[0101] The packaging module is to package the filled toothpaste and label it with the product name, ingredients, and usage information;

[0102] The detection module refers to the content detection of fluoride content, diketafur, pH value, stability and microbial indicators in the paste.

[0103] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A novel anti-caries and anti-tooth decay formula, comprising a raw material package using auxiliary materials, characterized in that: The raw material package comprises sodium fluoride raw material and diketafur raw material.

2. A novel anti-caries and anti-tooth decay formula according to claim 1, characterized in that: The content of the sodium fluoride raw material is 0.05%-0.25%, and the content of the diketafur raw material is 0.2%-3% to obtain a toothpaste finished product A.

3. A novel anti-caries and anti-tooth decay formula according to claim 2, characterized in that: The content of the sodium fluoride raw material is 0.1%-0.2%, and the content of the diketafur raw material is 0.5%-2.5% to obtain a toothpaste product B.

4. A novel anti-caries and anti-tooth decay formula according to claim 3, characterized in that: The content of the sodium fluoride raw material is 0.15%-0.18%, and the content of the diketafur raw material is 1.5%-2% to obtain a toothpaste finished product C.

5. A novel anti-caries and anti-tooth decay formula according to claim 4, comprising the following steps: Step S1, preparing materials: Step S1, preparing materials refers to preparing auxiliary materials, sodium fluoride raw materials, and diketafur raw materials; Step S2, proportioning and weighing; Step S3, raw material pretreatment; Step S4, paste processing group.

6. A novel anti-caries and anti-tooth decay formula according to claim 5, characterized in that: The weighing and proportioning refer to scientific proportioning according to the differences of auxiliary materials, sodium fluoride raw materials, and diketafur raw materials, and the use of weighing equipment to accurately weigh the proportioned auxiliary materials, sodium fluoride raw materials, and diketafur raw materials.

7. A novel anti-caries and anti-tooth decay formula according to claim 6, characterized in that: The raw material pretreatment includes dissolution treatment; The dissolving process refers to adding the sodium fluoride raw material and the diketafur raw material into the liquid raw material for pre-mixing.

8. A novel anti-caries and anti-tooth decay formula according to claim 7, characterized in that: The paste processing group includes a mixing module, a color adjustment module, a flavoring module, a filling module, a packaging module, and a detection module.

9. A novel anti-caries and anti-tooth decay formula according to claim 8, characterized in that: The mixing module is to put the auxiliary materials, sodium fluoride raw materials, and diketafur raw materials into the stirring equipment for thorough mixing; The color adjustment module is to drop the pigment into the mixed paste to make the paste reach the desired color; The flavoring module is used to add sweeteners and spices into the mixed paste to adjust the taste of the paste; The filling module is to fill the prepared paste into a toothpaste tube or a light-proof container through a filling device; The packaging module is to package the filled toothpaste and affix labels with the product name, ingredients, and usage information; The detection module is used to detect the fluorine content, diketafur, pH value, stability and microbial indicators in the paste.

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