Moisturizing cream finishing agent containing water-soluble honeysuckle flower oil

Abstract

The invention relates to a preparation method of a moisturizing cream finishing agent containing water-soluble honeysuckle flower oil. Wherein the water-soluble honeysuckle flower oil is obtained by catalyzing a ring-opening polymerization reaction between hydroxyl in the honeysuckle flower oil and ethylene oxide through boron trifluoride diethyl etherate, has good antibacterial and anticorrosive properties, and accounts for 10% of the moisturizing cream finishing agent by mass.

Description

Technical Field

[0001] The invention relates to a preparation method of a moisturizing cream finishing agent containing water-soluble honeysuckle oil. Background Art

[0002] Moisturizing cream tissues have a moisturizing, smooth and soft texture, and are especially suitable for infants, children and patients with allergic rhinitis.

[0003] Moisturizing cream tissue paper is prepared by finishing tissue base paper with a moisturizing cream finishing agent. The preparation process is usually roller coating or spraying, and the conventional coating rate of the finishing agent is 25-35% of the base paper mass.

[0004] The main ingredients of moisturizing cream finishing agents are: moisturizer, softener, smoothing agent, preservative, acid regulator, defoaming agent, metal ion chelating agent, deionized water, etc.

[0005] Preservatives in moisturizing cream finishes are crucial, ensuring not only the hygienic properties of the finish itself but also the hygienic properties of the moisturizing cream sheet after application (moisturizing cream sheets typically contain a high level of moisture, making them susceptible to bacterial growth). These preservatives are typically water-soluble compounds such as chlorhexidine and formaldehyde-releasing agents (e.g., Bromopol), or water-soluble cationic biocides (e.g., chlorhexidine and benzyl alcohol). Given that moisturizing cream sheets are primarily intended for use on infants and children with sensitive skin, these chemical preservatives and biocides pose a potential threat to consumer skin safety and are therefore subject to controversy.

[0006] Honeysuckle oil is a pale yellow natural essential oil extracted from honeysuckle (the dried flower buds of Lonicera japonica, a plant of the Caprifoliaceae family). Honeysuckle oil has a wide range of medicinal uses, particularly its excellent antibacterial properties, making it useful in treating a variety of skin infections.

[0007] Honeysuckle oil is insoluble in water, and its excellent antibacterial properties cannot be applied to water-based products such as moisturizing creams and finishing agents because fungi primarily reside in the aqueous phase. Conventional surfactant solubilization technology can make honeysuckle oil soluble in water, but this solubilization process occurs because the surfactant encapsulates the oil in the form of micelles, preventing it from actually entering the aqueous phase and, therefore, preventing it from exerting its antibacterial and antiseptic properties. Summary of the Invention

[0008] In order to solve the problems existing in the prior art, the present invention provides a preparation method of water-soluble honeysuckle oil and the prepared water-soluble honeysuckle oil, and also provides a preparation method of a moisturizing cream finishing agent containing the water-soluble honeysuckle oil and the prepared moisturizing cream finishing agent.

[0009] According to public data, honeysuckle oil contains dozens of chemical components, among which alcohol compounds account for more than 25% by mass, including linalool, terpineol, geraniol, nerol, etc.

[0010] All of these alcohols contain one or more hydroxyl groups, making them highly chemically modifiable. In the presence of a catalyst, the hydroxyl groups in these compounds react with ethylene oxide to form ethylene glycol chains, which readily form hydrogen bonds in water, resulting in excellent water solubility.

[0011] The present invention uses honeysuckle oil and ethylene oxide as main raw materials. The hydroxyl groups in the honeysuckle oil molecules undergo a ring-opening polymerization reaction with ethylene oxide in the presence of a catalyst, boron trifluoride etherate, to synthesize ethylene oxide-modified water-soluble honeysuckle oil. The oil is a mixture of honeysuckle oil polyoxyethylene ethers, but all are produced by the same type of reaction.

[0012] The specific preparation method of the water-soluble honeysuckle oil of the present invention is: At room temperature, add honeysuckle oil and the catalyst boron trifluoride etherate to a reactor in a mass ratio of 40:1. Seal the reactor and heat to 45°C. Simultaneously, start stirring at 150 r / min. Then, evacuate and vent with nitrogen. Repeat five times to maintain an inert atmosphere. Add ethylene oxide in an amount equal to 3.5 times the mass of the honeysuckle oil in the reaction. After the addition of ethylene oxide, maintain the original temperature and stirring speed. The reaction is complete when the reactor pressure drops to a value close to zero and remains essentially unchanged. Connect condensed water for cooling, and discharging the material after the temperature drops below 25°C.

[0013] At this time, the final product is the water-soluble honeysuckle oil of the present invention, which is a light yellow transparent viscous liquid. Its maximum solubility in water is measured to be 10g / 100ml.

[0014] The antibacterial test of the water-soluble honeysuckle oil of the present invention is as follows: Water-soluble honeysuckle oil was prepared with sterile distilled water at a series of concentration gradients (mass percentage: 1.0%, 2.0%, 3.0%, 4.0%, and 5.0%). Its 20-minute antibacterial properties against Staphylococcus aureus (a representative species of pyogenic cocci), Escherichia coli (a representative species of enteric infection), and Candida albicans (a representative species of fungi) were tested. The results are shown in the table.

[0015] Comparative test results of antibacterial properties of water-soluble honeysuckle oil solutions with different concentrations

[0016] As can be seen from the above table: when the mass percentage of the antibacterial agent is 3%, the inhibition rate against the three representative bacterial species is > 90%, showing a strong antibacterial effect; when the mass percentage of the antibacterial agent is 5%, the inhibition rate against the three representative bacterial species can reach 100%; under the same dosage conditions, the antibacterial effect of the antibacterial agent on the three bacterial species varies, among which the effect on Staphylococcus aureus is the best, followed by Escherichia coli, and the antibacterial effect on Candida albicans is relatively weak.

[0017] The water-soluble honeysuckle oil of the present invention has the advantages of good water solubility through simple chemical modification, while maintaining the good antibacterial properties of the honeysuckle oil itself, thereby overcoming the disadvantage that the honeysuckle oil cannot be used for aqueous antibacterial applications.

[0018] The antibacterial mechanism of the water-soluble honeysuckle oil of the present invention is mainly to inhibit the reaction of certain enzymes or inhibit the synthesis of enzymes in biological cells.

[0019] Preparation method of a moisturizing cream finishing agent containing the water-soluble honeysuckle oil of the present invention: At room temperature, the following components were added to a stirred tank in order by mass: 60% glycerol (main moisturizer), 2% 1,3-propylene glycol, 10% water-soluble honeysuckle oil, 0.5% octadecyl fatty alcohol polyoxyethylene ether (20) (main lubricant), 0.1% citric acid, 0.1% disodium ethylenediaminetetraacetic acid (chelating agent), and 0.1% silicone defoaming agent. Deionized water was added to 100%, and stirring was started at a speed of 30 rpm. Stirring was continued for 30 minutes, and the material was discharged to obtain a moisturizing cream finishing agent containing the water-soluble honeysuckle oil of the present invention.

[0020] The moisturizing cream finishing agent of the present invention is a translucent, flowable light blue viscous liquid with a viscosity of 30±2 Pa·s (25°C), a pH value of 5.5±0.3, and a very slight characteristic odor. Its 20-minute antibacterial rates against Staphylococcus aureus, Escherichia coli, and Candida albicans are all greater than 99%, and it is non-irritating to the skin and will not cause skin allergic reactions.

[0021] The application process of the moisturizing cream finishing agent of the present invention can be carried out according to known techniques, including the coating method (spraying or roller coating), coating rate (25-35%), line speed, etc.

[0022] Experiments have shown that the moisturizing cream paper prepared by using the moisturizing cream finishing agent of the present invention has good moisturizing and smoothing properties, and the bacterial and fungal contents are both less than 10 cfu / g. DETAILED DESCRIPTION

[0023] The present invention is further described through examples, the purpose of which is only to provide a better understanding of the content of the present invention. Therefore, the examples given do not limit the scope of protection of the present invention. Example

[0024] Step 1: Preparation of water-soluble honeysuckle oil 1. Check the vacuum degree of the reactor to ensure that there is no leakage in the pipeline and the nitrogen is flowing smoothly.

[0025] 2. At room temperature, add 400 g of commercially available honeysuckle oil and 10 g of catalyst boron trifluoride etherate into the reactor, seal it, heat it to 45°C, and stir it (150 r / min).

[0026] 3. Evacuate the reactor and pass nitrogen gas, repeat 5 times to keep the reactor in an inert gas environment.

[0027] 4. Add 1400 g of ethylene oxide and continue the reaction at the original temperature and stirring speed. The reaction is completed when the pressure in the reactor drops to a value close to zero and remains substantially unchanged.

[0028] 5. Connect the condensation water for cooling and discharge the material when the temperature drops below 25℃.

[0029] Step 2: Preparation of a moisturizing cream finishing agent containing water-soluble honeysuckle oil At room temperature, the following components were added to the stirred tank in order by mass: 60% propylene glycol, 2% 1,3-propylene glycol, 10% water-soluble honeysuckle oil, 0.5% octadecyl fatty alcohol polyoxyethylene ether (20), 0.1% citric acid, 0.1% disodium ethylenediaminetetraacetic acid, and 0.1% silicone defoamer. Deionized water was added to 100%, and stirring was started at a speed of 30 rpm. Stirring was continued for 30 minutes, and the material was discharged.

Claims

1. A method for preparing water-soluble honeysuckle oil, comprising: At room temperature, honeysuckle oil and catalyst boron trifluoride etherate were added to a reactor at a mass ratio of 40:1 and sealed. Heat to 45°C; stir at a stirring speed of 150 r / min; evacuate and pass nitrogen, repeat 5 times to place the reactor in an inert gas environment; add ethylene oxide, the amount of ethylene oxide added is 3.5 times the mass of the honeysuckle oil in the reaction, maintain the original temperature and stirring speed, and react; the reaction is completed when the pressure in the reactor drops to a gauge pressure close to zero and remains basically unchanged; connect condensed water for cooling, and discharge the material when the temperature drops below 25°C.

2. according to claim 1, the preparation method of the moisturizing cream finishing agent containing water-soluble honeysuckle oil comprises: At room temperature, the following components were added to the stirred tank in order by mass: 60% propylene glycol, 2% 1,3-propylene glycol, 10% water-soluble honeysuckle oil, 0.5% octadecyl fatty alcohol polyoxyethylene ether (20), 0.1% citric acid, 0.1% disodium ethylenediaminetetraacetic acid, and 0.1% silicone defoamer. Deionized water was added to 100%, and stirring was started at a speed of 30 rpm. Stirring was continued for 30 minutes, and the material was discharged.

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