Stomach filling agent and preparation method thereof

Abstract

The invention relates to the technical field of stomach filling agents, and particularly discloses a stomach filling agent and a preparation method thereof. The stomach filling agent is prepared from, by weight, 50-75 parts of composite hydrogel, 1.7-2.8 parts of digestion promoting microcapsules and 0.7-1.2 parts of helicobacter pylori resisting matter, the composite hydrogel is formed by crosslinking sodium alginate and sulfhydrylated fructose-chitosan, the capsule wall of each digestion promoting microcapsule is gelatin and sodium alginate, and the capsule wall of each digestion promoting microcapsule is gelatin and sodium alginate. The core of the digestion promoting microcapsule is chitosanase; in addition, the preparation method disclosed by the invention has the advantages of reducing the stimulation of the gastric filling agent to gastric mucosa and improving the multifunctionality of the gastric filling agent.

Description

Technical Field

[0001] The present application relates to the technical field of gastric fillers, and more particularly, to a gastric filler and a preparation method thereof. Background Art

[0002] Gastric fillers are a common treatment for digestive system diseases. Currently, gastric fillers mainly rely on chemical synthetic materials, such as polyvinyl alcohol, silica gel, sodium alginate derivatives, etc., to form a protective layer on the surface of the gastric mucosa, separating the gastric mucosa from gastric acid, thereby achieving the purpose of relieving gastric acid irritation and ulcer pain.

[0003] However, in actual use, the chemical synthetic materials of existing gastric fillers will affect the repair of gastric mucosa and cause irritation to the gastric mucosa. Although there is a certain relief effect, pain symptoms still occur. At the same time, some materials are not easily digested and absorbed by the human body, and accumulate in the gastrointestinal tract, causing discomfort to the human body. Summary of the Invention

[0004] In order to reduce the irritation of gastric fillers to the gastric mucosa and improve the multifunctionality of gastric fillers, the present application provides a gastric filler and a preparation method thereof.

[0005] In a first aspect, the present application provides a gastric filler, which adopts the following technical solution: A stomach filler comprises the following raw materials in parts by weight: 50-75 parts of composite hydrogel, 1.7-2.8 parts of digestion-promoting microcapsules, and 0.7-1.2 parts of anti-Helicobacter pylori substances. The walls of the digestion-promoting microcapsules are made of gelatin and sodium alginate, and the core of the digestion-promoting microcapsules is chitosanase.

[0006] By adopting the above technical solution, the composite hydrogel has good swelling properties. After entering the stomach, it can swell in gastric acid and coat the stomach wall, thereby alleviating the irritation of gastric acid to the gastric mucosa. At the same time, the anti-Helicobacter pylori can effectively inhibit the growth and reproduction of Helicobacter pylori and relieve the symptoms of gastric ulcers. The digestive microcapsules are coated with chitosanase. When the gastric filler enters the intestine with digestion, sodium alginate and gelatin decompose and slowly release chitosanase, which cooperates with the digestive enzymes and flora in the intestine to enzymatically hydrolyze or hydrolyze the composite hydrogel and decompose it into small molecular substances, such as chitosan oligosaccharides, which are beneficial to human absorption and promote the decomposition and digestion and absorption of the gastric filler.

[0007] Preferably, the composite hydrogel is a sodium alginate / thiolated fructose-chitosan composite gel, the chitosan deacetylation degree in the thiolated fructose-chitosan is 90-95%, and the mass ratio of the sodium alginate to the thiolated fructose-chitosan is (6.48-7.35):(2.87-3.29).

[0008] By adopting the above technical solution, the deacetylation degree of chitosan is controlled, so that the chitosan oligosaccharides obtained after enzymatic hydrolysis by chitosanase also have a high deacetylation degree. The chitosan oligosaccharides with a high deacetylation degree are conducive to human absorption and utilization, so that the gastric filler is decomposed after entering the intestine, and the decomposition products can be absorbed by the human body as nutrients. The mass ratio of sodium alginate and thiolated fructose-chitosan is controlled, so that the composite hydrogel maintains a good gel shape and swelling property in the stomach, fully exerting its relief effect. After entering the intestine, it continues to swell until it disintegrates and decomposes, and is absorbed and utilized by the intestine.

[0009] Preferably, the preparation method of the composite hydrogel comprises the following steps: dissolving thiolated fructose-chitosan in water to obtain a thiolated fructose-chitosan solution, dissolving sodium alginate in water to obtain a sodium alginate solution, adding the thiolated fructose-chitosan solution and mixing, adding a calcium chloride solution, stirring and cross-linking for 1 hour, fully washing, immersing in a sodium sulfate solution for cross-linking for 30 minutes, separating, washing, and freeze-drying.

[0010] By adopting the above technical solution, the thiolated fructose-chitosan solution is mixed with the sodium alginate solution, and cross-linked by exchanging with calcium ions, a gastric filler with better relief effect, capable of treating gastric ulcers and promoting digestion is prepared.

[0011] Preferably, the composite hydrogel is a chitosan / gelatin composite gel, and the preparation method of the chitosan / gelatin composite gel comprises the following steps: dissolving chitosan in acetic acid solution, dissolving gelatin in water at 65° C. and cooling for standby use, mixing the chitosan acetic acid solution and the gelatin solution, adding glutaraldehyde solution and mixing thoroughly, standing to crosslink to form a gel, washing, and freeze-drying.

[0012] By adopting the above technical solution, glutaraldehyde is used as a cross-linking agent to cross-link gelatin and chitosan to prepare a composite gel.

[0013] Preferably, the preparation method of the digestion-promoting microcapsules comprises the following steps: dissolving sodium alginate and gelatin in water to form a composite solution, adding chitosanase and ultrasonically dispersing the solution, spraying the solution into a calcium chloride solution, standing and solidifying for 30-40 minutes, centrifuging, separating, and freeze-drying to obtain the digestion-promoting microcapsules.

[0014] By adopting the above technical solution, sodium alginate and gelatin are mixed with each other, and chitosanase is encapsulated therein, which is exchanged with calcium ions to achieve gelation. After solidification, digestive microcapsules with a core-shell structure are obtained, so that the digestive microcapsules can slowly release chitosanase.

[0015] Preferably, the mass ratio of gelatin to sodium alginate is (1.29-1.65):(3.42-3.82).

[0016] By adopting the above technical solution and controlling the mass ratio of gelatin to sodium alginate, the digestion-promoting microcapsules have a better ball-forming rate, are formed more regularly, and have a higher chitosanase encapsulation rate and embedding rate.

[0017] Preferably, the wall-core ratio of the digestion-promoting microcapsules is 1:(0.76-0.89).

[0018] By adopting the above technical solution, the wall-core ratio of the digestion-promoting microcapsules is controlled, so that the digestion-promoting microcapsules are better formed, the formed digestion-promoting microcapsules have uniform shape, moderate size, and high chitosanase encapsulation rate.

[0019] Preferably, nano bamboo shoot dietary fiber is further added to the composite solution, and the added amount of nano bamboo shoot dietary fiber is 3.54-5.21 wt % of the sodium alginate.

[0020] By adopting the above technical solution, the addition of nano bamboo shoot dietary fiber allows the digestive microcapsules to decompose in the intestines, and the dietary fiber plays a role in the intestines, promoting intestinal peristalsis and digestion, thereby improving the body's decomposition and absorption of the gastric filler.

[0021] In a second aspect, the present application provides a method for preparing a gastric filler, which adopts the following technical solution: A method for preparing a gastric filler comprises the following steps: adding digestion-promoting microcapsules and anti-Helicobacter pylori substances during the preparation of a composite hydrogel, and dispersing them evenly to prepare the gastric filler.

[0022] By adopting the above technical solution, digestive-promoting microcapsules and anti-Helicobacter pylori substances are added, so that the two are embedded in the composite hydrogel, thereby obtaining a gastric filler with good swelling and adhesion properties, and can slowly release anti-Helicobacter pylori substances to relieve gastric ulcer symptoms. After the gastric filler enters the intestine, it can be decomposed, digested and absorbed without intestinal blockage.

[0023] In summary, this application has the following beneficial effects: 1. Since the composite hydrogel in the present application has good swelling properties, it can swell in gastric acid and coat the stomach wall after entering the stomach, thereby alleviating the irritation of gastric acid to the gastric mucosa. At the same time, the anti-Helicobacter pylori can effectively inhibit the growth and reproduction of Helicobacter pylori, relieving the symptoms of gastric ulcers. The digestive microcapsules are coated with chitosanase. When the gastric filler enters the intestine with digestion, sodium alginate and gelatin decompose and slowly release chitosanase, which cooperates with the digestive enzymes and flora in the intestine to enzymatically hydrolyze or hydrolyze the composite hydrogel and decompose it into small molecules, such as chitosan oligosaccharides, which are beneficial to human absorption and promote the decomposition and digestion and absorption of the gastric filler.

[0024] 2. In the present application, the deacetylation degree of chitosan is controlled so that the chitosan oligosaccharides obtained after enzymatic hydrolysis by chitosanase also have a high deacetylation degree. Chitosan oligosaccharides with a high deacetylation degree are beneficial to human absorption and utilization, so that the gastric filler is decomposed after entering the intestine, and the decomposition products can be absorbed by the human body as nutrients.

[0025] 3. The addition of nano bamboo shoot dietary fiber in this application allows the digestion-promoting microcapsules to decompose in the intestines, and the dietary fiber plays a role in the intestines, promoting intestinal peristalsis and digestion, thereby improving the body's decomposition and absorption of the gastric filler. DETAILED DESCRIPTION

[0026] The present application is further described in detail below with reference to the embodiments.

[0027] Preparation Example of Thiolated Fructose-Chitosan Preparation Example 1 The preparation method of thiolated fructose-chitosan comprises the following steps: dissolving 4 g of chitosan in 90 mL of 2 wt% acetic acid solution, adding 8.425 g of fructose and reacting for 4 h, adding sodium borohydride for reduction for 24 h, terminating the reaction with 95% ethanol, separating, washing, filtering, and drying to obtain fructose-chitosan; and dissolving 0.2 g of cysteine ​​in 50 mL of dimethyl sulfoxide, adding 0.418 g of dicyclohexylcarbodiimide, 0.167 g of 4-dimethylaminopyridine, and 1 g of fructose-chitosan, reacting at room temperature for 24 h, dialyzing the reaction product for 2 days each time, for a total of 3 times, washing, filtering, and freeze-drying to obtain thiolated fructose-chitosan.

[0028] Preparation Example 2-11 of Digestion-Promoting Microcapsules Preparation Example 2 The preparation method of digestion-promoting microcapsules includes the following steps: dissolving sodium alginate and gelatin in water to form a composite solution, wherein the mass ratio of gelatin to sodium alginate is 1.29:3.42, and the mass fraction of sodium alginate is 10wt%, adding chitosanase and ultrasonically dispersing the solution, spraying the solution into a 2wt% calcium chloride solution, standing and solidifying for 30 minutes, centrifuging, separating, and freeze-drying to obtain digestion-promoting microcapsules, wherein the wall-core ratio of the digestion-promoting microcapsules is 1:0.76.

[0029] Preparation Example 3 The preparation method of digestion-promoting microcapsules includes the following steps: dissolving sodium alginate and gelatin in water to form a composite solution, wherein the mass ratio of gelatin to sodium alginate is 1.65:3.82, and the mass fraction of sodium alginate is 10wt%, adding chitosanase and ultrasonically dispersing the solution, spraying the solution into a 2wt% calcium chloride solution, standing and solidifying for 40 minutes, centrifuging, separating, and freeze-drying to obtain digestion-promoting microcapsules, wherein the wall-core ratio of the digestion-promoting microcapsules is 1:0.89.

[0030] Preparation Example 4 The difference between Preparation Example 4 and Preparation Example 2 is that in Preparation Example 4, the mass ratio of gelatin to sodium alginate is 1.29:2.68.

[0031] Preparation Example 5 The difference between Preparation Example 5 and Preparation Example 2 is that in Preparation Example 5, the mass ratio of gelatin to sodium alginate is 1.29:4.95.

[0032] Preparation Example 6 The difference between Preparation Example 6 and Preparation Example 2 is that in Preparation Example 6, the wall-core ratio of the digestion-promoting microcapsules is 1:0.25.

[0033] Preparation Example 7 The difference between Preparation Example 7 and Preparation Example 2 is that in Preparation Example 7, the wall-core ratio of the digestion-promoting microcapsules is 1:1.65.

[0034] Preparation Example 8 The difference between Preparation Example 8 and Preparation Example 2 is that in Preparation Example 8, nano bamboo shoot dietary fiber is further added to the composite solution, and the added amount of nano bamboo shoot dietary fiber is 3.54 wt % of the sodium alginate.

[0035] Preparation Example 9 The difference between Preparation Example 9 and Preparation Example 2 is that in Preparation Example 9, nano bamboo shoot dietary fiber is further added to the composite solution, and the added amount of the nano bamboo shoot dietary fiber is 5.21 wt % of the sodium alginate.

[0036] Preparation Example 10 The difference between Preparation Example 10 and Preparation Example 8 is that in Preparation Example 10, the added amount of nano bamboo shoot dietary fiber is 1.62 wt % of sodium alginate.

[0037] Preparation Example 11 The difference between Preparation Example 11 and Preparation Example 8 is that in Preparation Example 11, the added amount of nano bamboo shoot dietary fiber is 7.95 wt % of sodium alginate. Example

[0038] Example 1 A gastric filler comprises the following raw materials in parts by weight: 50 g of a composite hydrogel, 1.7 g of digestion-promoting microcapsules, and 0.7 g of an anti-Helicobacter pylori substance, wherein the anti-Helicobacter pylori substance is selected from curcumin and allicin in a mass ratio of 1.23:1.18; the composite hydrogel is a sodium alginate / thiolated fructose-chitosan composite gel; the thiolated fructose-chitosan is selected from the thiolated fructose-chitosan prepared in Preparation Example 1; the capsule wall of the digestion-promoting microcapsule is gelatin and sodium alginate; the capsule core of the digestion-promoting microcapsule is chitosanase; and the digestion-promoting microcapsules are selected from the digestion-promoting microcapsules prepared in Preparation Example 2.

[0039] The preparation method of the above-mentioned gastric filler comprises the following steps: dissolving thiolated fructose-chitosan in water to obtain a 0.2 g / L thiolated fructose-chitosan solution; dissolving sodium alginate in water to obtain a 0.2 g / L sodium alginate solution; stirring and dispersing digestion-promoting microcapsules and anti-Helicobacter pylori substances in the sodium alginate solution; adding the thiolated fructose-chitosan solution and mixing; wherein the mass ratio of sodium alginate to thiolated fructose-chitosan is 6.48:2.87; adding 2 wt % calcium chloride solution; stirring and cross-linking for 1 hour; washing thoroughly; immersing in a 2 wt % sodium sulfate solution for cross-linking for 30 minutes; separating, washing, and freeze-drying.

[0040] Example 2 A gastric filler comprises the following raw materials in parts by weight: 75 g of a composite hydrogel, 2.8 g of digestion-promoting microcapsules, and 1.2 g of an anti-Helicobacter pylori substance, wherein the anti-Helicobacter pylori substance is selected from curcumin and allicin in a mass ratio of 1.23:1.18; the composite hydrogel is a sodium alginate / thiolated fructose-chitosan composite gel; the thiolated fructose-chitosan is selected from the thiolated fructose-chitosan prepared in Preparation Example 1; the capsule wall of the digestion-promoting microcapsule is gelatin and sodium alginate; the capsule core of the digestion-promoting microcapsule is chitosanase; and the digestion-promoting microcapsules are selected from the digestion-promoting microcapsules prepared in Preparation Example 3.

[0041] The preparation method of the above-mentioned gastric filler comprises the following steps: dissolving thiolated fructose-chitosan in water to obtain a 0.2 g / L thiolated fructose-chitosan solution; dissolving sodium alginate in water to obtain a 0.2 g / L sodium alginate solution; stirring and dispersing digestion-promoting microcapsules and anti-Helicobacter pylori substances in the sodium alginate solution; adding the thiolated fructose-chitosan solution and mixing; wherein the mass ratio of sodium alginate to thiolated fructose-chitosan is 7.35:3.29; adding 2 wt % calcium chloride solution; stirring and cross-linking for 1 hour; washing thoroughly; immersing in a 2 wt % sodium sulfate solution for cross-linking for 30 minutes; separating, washing, and freeze-drying.

[0042] Example 3 A gastric filler comprises the following raw materials in parts by weight: 75 g of a composite hydrogel, 2.8 g of digestion-promoting microcapsules, and 1.2 g of an anti-Helicobacter pylori substance, wherein the anti-Helicobacter pylori substance is selected from curcumin and allicin in a mass ratio of 1.23:1.18; the composite hydrogel is a chitosan / gelatin composite gel; the capsule wall of the digestion-promoting microcapsule is gelatin and sodium alginate; the capsule core of the digestion-promoting microcapsule is chitosanase; and the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 2.

[0043] The preparation method of the above-mentioned gastric filler comprises the following steps: dissolving chitosan in a 2wt% acetic acid solution to form a 3wt% chitosan acetic acid solution; dissolving gelatin in water at 65°C to prepare an 8wt% gelatin solution, cooling the solution for later use; mixing the chitosan acetic acid solution and the gelatin solution in a volume ratio of 1:1 to obtain 400mL of the mixed solution; adding 3mL of a 2wt% glutaraldehyde solution, mixing thoroughly, standing to crosslink and form a gel, washing, and freeze-drying.

[0044] Example 4 The difference between Example 4 and Example 1 is that in Example 4, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 4.

[0045] Example 5 The difference between Example 5 and Example 1 is that in Example 5, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 5.

[0046] Example 6 The difference between Example 6 and Example 1 is that in Example 6, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 6.

[0047] Example 7 The difference between Example 7 and Example 1 is that in Example 7, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 7.

[0048] Example 8 The difference between Example 8 and Example 1 is that in Example 8, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 8.

[0049] Example 9 The difference between Example 9 and Example 1 is that in Example 9, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 9.

[0050] Example 10 The difference between Example 10 and Example 1 is that in Example 10, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 10.

[0051] Example 11 The difference between Example 11 and Example 1 is that in Example 11, the digestion-promoting microcapsules are the digestion-promoting microcapsules prepared in Preparation Example 11.

[0052] Example 12 The difference between Example 12 and Example 1 is that in Example 12, the mass ratio of sodium alginate to thiolated fructose-chitosan is 9:1.

[0053] Example 13 The difference between Example 13 and Example 1 is that in Example 13, the mass ratio of sodium alginate to thiolated fructose-chitosan is 4:6.

[0054] Comparative Example Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that no digestion-promoting microcapsules are added in Comparative Example 1.

[0055] Performance testing A gastric filler was prepared according to the materials and methods of Examples 1-13 and Comparative Example 1. The gastric filler was placed in in vitro simulated gastric digestive fluid for 4 hours and in in vitro simulated intestinal digestive fluid for 20 hours. The reducing sugar production was determined by the DNS method, and the degradation rate of chitosan was calculated and recorded in Table 1. The volume swelling ratio of the gastric filler in in vitro simulated gastric digestive fluid and in vitro simulated intestinal digestive fluid was also determined.

[0056] Table 1 Performance test results of gastric filler project Degradation rate / % Gastric swelling ratio Intestinal swelling ratio Example 1 78 57.62 76.58 Example 2 76 58.15 87.16 Example 3 81 52.68 74.25 Example 4 62 57.68 74.25 Example 5 61 56.95 75.81 Example 6 63 56.67 76.34 Example 7 62 57.91 78.26 Example 8 77 58.25 77.84 Example 9 76 57.37 79.16 Example 10 79 56.56 78.82 Example 11 78 58.18 77.34 Example 12 79 32.54 91.16 Example 13 76 33.61 90.52 Comparative Example 1 43 56.21 78.28 According to Table 1, Examples 1-3, and Comparative Example 1, it can be seen that the gastric fillers prepared in Examples 1-2 have a good swelling rate in the stomach, while the swelling rate in the intestine is improved. The composite hydrogel has a high degradation rate. The composite hydrogel is formed by cross-linking sodium alginate and thiolated fructose-chitosan, or by cross-linking chitosan and gelatin under the action of glutaraldehyde. It has good swelling properties and can swell and coat the stomach wall upon entering the stomach, thereby alleviating irritation of the gastric mucosa. At the same time, it slowly releases anti-Helicobacter pylori substances to alleviate gastric ulcer symptoms. After the composite hydrogel enters the intestine, the swelling rate is further increased, allowing the digestive microcapsules in the composite hydrogel to come into contact with the intestinal fluid and gradually decompose. Chitosanase is slowly released and synergistically decomposes the gastric filler with active enzymes and flora in the intestine, effectively improving the degradation rate of the gastric filler and promoting the absorption and utilization of the degradation products by the human body.

[0057] Compared with Example 1-2, the degradation rate of the composite hydrogel of Example 4-7 is decreased. When preparing the digestion-promoting microcapsules of Example 4-5, the mass ratio of gelatin to sodium alginate is changed. When preparing the digestion-promoting microcapsules of Example 6-7, the wall-core ratio of the digestion-promoting microcapsules is changed. This shows that the wall-core ratio of the digestion-promoting microcapsules and the mass ratio of gelatin to sodium alginate constituting the capsule wall both affect the effect of the digestion-promoting microcapsules. The wall-core ratio and mass ratio affect the molding effect of the digestion-promoting microcapsules and the encapsulation rate of chitosanase, thereby affecting the promotion of the degradation effect of the digestion-promoting microcapsules on the gastric filler, resulting in a decrease in the degradation rate of chitosan.

[0058] Compared with Example 1-2, Example 8-11 has a better swelling rate in the stomach and still has a high swelling rate in the intestine. The degradation rate of the composite hydrogel is high. The gastric filler prepared in Example 8-11 was continuously gavaged into mice for 28 days. The weight of the mice treated with Example 8-9 by gavage was compared with the weight of the mice not treated with gavage. The weight of the mice treated with gavage was higher and the defecation volume was increased, indicating that the gastric filler prepared in Example 8-9 has the function of promoting intestinal peristalsis and digestion and absorption. At the same time, the gastric filler did not cause intestinal blockage. The weight and defecation volume of the mice treated with Example 10-11 by gavage were lower than those of Example 8-9, indicating that the addition amount of nano bamboo shoot dietary fiber affects the digestion-promoting effect of the digestive microcapsules, and too high or too low amount can easily reduce its digestion-promoting effect.

[0059] Compared with Examples 1-2, Examples 12-13 have an increased swelling rate in the intestine and a higher degradation rate of the composite hydrogel. However, the swelling rate in the stomach decreases, resulting in poor sustained release of anti-Helicobacter pylori substances in the stomach by the gastric filler prepared in Examples 12-13. Furthermore, the viscosity of the gastric filler decreases, making it unable to effectively coat the stomach wall and alleviate gastric mucosal irritation and gastric ulcer symptoms.

[0060] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A stomach filler, characterized in that: The invention comprises the following raw materials in parts by weight: 50-75 parts of composite hydrogel, 1.7-2.8 parts of digestion-promoting microcapsules, and 0.7-1.2 parts of anti-Helicobacter pylori substances. The capsule wall of the digestion-promoting microcapsules is gelatin and sodium alginate, and the capsule core of the digestion-promoting microcapsules is chitosanase.

2. A gastric filler according to claim 1, characterized in that: The composite hydrogel is a sodium alginate / thiolated fructose-chitosan composite gel, the chitosan deacetylation degree in the thiolated fructose-chitosan is 90-95%, and the mass ratio of the sodium alginate to the thiolated fructose-chitosan is (6.48-7.35):(2.87-3.29).

3. A stomach filler according to claim 2, characterized in that: The preparation method of the composite hydrogel comprises the following steps: dissolving thiolated fructose-chitosan in water to obtain a thiolated fructose-chitosan solution, dissolving sodium alginate in water to obtain a sodium alginate solution, adding the thiolated fructose-chitosan solution and mixing, adding a calcium chloride solution, stirring and cross-linking for 1 hour, fully washing, immersing in a sodium sulfate solution for cross-linking for 30 minutes, separating, washing, and freeze-drying.

4. The stomach filler according to claim 1, characterized in that: The composite hydrogel is a chitosan / gelatin composite gel. The preparation method of the chitosan / gelatin composite gel comprises the following steps: dissolving chitosan in an acetic acid solution, dissolving gelatin in water at 65° C. and cooling for standby use, mixing the chitosan acetic acid solution and the gelatin solution, adding a glutaraldehyde solution and fully mixing, standing to crosslink to form a gel, washing, and freeze-drying.

5. The gastric filler according to claim 1, characterized in that: The preparation method of the digestion-promoting microcapsules comprises the following steps: dissolving sodium alginate and gelatin in water to form a composite solution, adding chitosanase and ultrasonically dispersing the solution, spraying the solution into a calcium chloride solution, standing the solution to solidify for 30-40 minutes, centrifuging, separating, and freeze-drying to obtain the digestion-promoting microcapsules.

6. The gastric filler according to claim 5, characterized in that: The mass ratio of gelatin to sodium alginate is (1.29-1.65):(3.42-3.82).

7. The stomach filler according to claim 5, characterized in that: The wall-core ratio of the digestion-promoting microcapsule is 1:(0.76-0.89).

8. The stomach filler according to claim 5, characterized in that: Nano bamboo shoot dietary fiber is further added to the composite solution, and the added amount of the nano bamboo shoot dietary fiber is 3.54-5.21 wt % of the sodium alginate.

9. The method for preparing a gastric filler according to any one of claims 1 to 8, characterized in that: The following steps are involved: During the preparation of the composite hydrogel, digestion-promoting microcapsules and anti-Helicobacter pylori substances are added and evenly dispersed to prepare a gastric filler.