Automatic mechanical pesticide application structure for microneedle patch pesticide application and pesticide application method thereof

Abstract

The invention provides an automatic mechanical pesticide application structure for microneedle patch pesticide application and a pesticide application method thereof, belongs to the medical field of microneedle patches, and solves the problems of low pesticide application efficiency, low automation degree and the like of an existing microneedle patch pesticide application structure. The pesticide applying structure comprises a base box and a top box, a sliding adjusting assembly is arranged in the base box, an arm placing assembly is arranged on the sliding adjusting assembly, a medical alcohol box, a transverse moving adjusting assembly, a lifting bearing assembly and two winding and unwinding assemblies are arranged above the base box, and the winding and unwinding assemblies are arranged above the top box. Two lifting position adjusting assemblies are arranged on the transverse movement adjusting assembly in a transmission mode, and a liquid sprayer and a pressing assembly are arranged on the two lifting position adjusting assemblies correspondingly; the pesticide application method comprises the following steps: setting in an early stage; carrying out patch loading and positioning; placing an arm; dynamically adjusting and spraying alcohol for disinfection; dynamically adjusting penetration and administration; drawing out the arm; removing the patch and carrying out post-processing; and the waste belt is rolled. The full process of spraying, pasting and pressing is automatic, hand pollution is completely eradicated, and efficiency is high.

Description

Technical Field

[0001] The present invention belongs to the field of microneedle patch medical technology, and relates to an automatic mechanical drug dispensing structure for microneedle patch drug dispensing, in particular to a drug dispensing method of the automatic mechanical drug dispensing structure for microneedle patch drug dispensing. Background Art

[0002] In modern medicine, transdermal drug delivery is an important method of drug delivery, offering advantages such as avoiding the first-pass effect on the liver, reducing gastrointestinal irritation, and maintaining stable blood drug concentrations. Microneedle patch technology, an innovative form of transdermal drug delivery, is becoming a hot topic in research and application. Microneedle patches pierce the skin's stratum corneum with micron-sized needle tips, creating drug permeation pathways without damaging nerves and blood vessels in the dermis. This significantly improves drug penetration efficiency and presents broad application prospects in areas such as vaccination, chronic disease treatment, and cosmetic skincare.

[0003] The technical pain points of traditional microneedle patch drug administration are prominent limitations of manual operation: the traditional drug administration process relies on manual completion by medical staff, and the operation accuracy is significantly affected by human factors. For example, uneven force may lead to inconsistent microneedle penetration depth, which not only affects the efficiency of drug release, but also may increase the patient's pain and skin damage risk.

[0004] Insufficient personalized adaptation capabilities: Different patients have different skin conditions (such as thickness and elasticity) and application sites (such as arms and backs). Traditional equipment finds it difficult to dynamically adjust application parameters based on real-time feedback, such as the pressing force and lateral position of microneedle patches, which limits its application in complex clinical scenarios.

[0005] Based on this, we propose an automatic mechanical drug delivery structure and a drug delivery method for microneedle patch drug delivery. Summary of the Invention

[0006] The purpose of the present invention is to address the above-mentioned problems in the existing technology and propose an automatic mechanical drug dispensing structure and drug dispensing method for microneedle patch dispensing. The technical problem to be solved by this invention is: how to realize the automation of the entire process of alcohol spraying-patch pressing, eliminate hand contamination, and at the same time ensure the stability and efficiency of drug dispensing.

[0007] The purpose of the present invention can be achieved through the following technical solutions:

[0008] An automatic mechanical drug dispensing structure for microneedle patch dispensing includes a base box and a top box arranged on the upper and rear sides of the base box, the top box is located above the base box, a sliding adjustment component is provided inside the base box, an arm placement component is provided on the upper end of the sliding adjustment component, the arm placement component is located above the base box and the arm placement component is located below the top box, a medical alcohol box, a lateral adjustment component, a lifting and placing component and two symmetrically arranged reel assemblies are provided above the base box, a reel assembly is provided above the top box, the reel assembly on the right side of the base box is a loading and unloading reel, and the reel assembly on the left side of the base box is The adhesive tape reel is installed, and the reel assembly on the top box is a pressing tape reel. The lateral adjustment assembly is provided with two lifting and positioning assemblies, one of which is provided with a sprayer, and a spray pump is provided between the sprayer and the medical alcohol tank. The other lifting and positioning assembly is provided with a pressing assembly, and the pressing assembly is located above the lifting and placing assembly. The lifting and positioning assembly, lateral adjustment assembly, lifting and placing assembly, pressing assembly and sprayer are all located inside the top box. A touch screen and a main control panel are provided on the inner top of the top box. The touch screen is flush with the top slope of the top box. Several visual sensors are provided at the lower end and inside of the top box.

[0009] Working Principle of the Invention: Preliminary Setup: The touch screen is the human-machine interface, through which the operator starts the device, selects programs, sets parameters, and monitors status; the main control board is the brain of the device, receiving instructions from the touch screen, processing sensor information, and precisely controlling all motors and components;

[0010] Patch loading and positioning: Place the roll of the microneedle patch tape containing the microneedle patch into the reel-up assembly on the right side of the base box, and extend the end of the roll of the microneedle patch tape into the interior of the top box;

[0011] Arm placement: The patient places their arm into the arm placement component, which tightens the arm. The visual sensor locates the position of the arm, which in turn locates the spatial location where the microneedle patch is inserted.

[0012] Dynamic adjustment of spraying alcohol disinfection: The sliding adjustment component drives the arm placement component to adjust its position according to the insertion position. The lateral adjustment component drives the two lifting and positioning components to move according to the insertion position, so that the arm insertion position is directly below the sprayer. The lifting and positioning component drives the sprayer to descend and be placed above the insertion position. The spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer, and the sprayer sprays at the insertion position. After the spraying is completed, the lifting and positioning component drives the sprayer to rise and reset;

[0013] Dynamic adjustment of insertion and drug administration: the sliding adjustment component drives the arm placement component to adjust its position according to the insertion position, and the lateral adjustment component drives the two lifting and positioning components to move according to the insertion position, so that the arm insertion position is located directly below the pressing component, and at this time the pressing component is located directly above the lifting and placing component; the lifting and positioning component drives the pressing component to descend, and the lifting and placing component is raised and lowered to a height equal to or higher than the height of the arm insertion position. The pressing component first cooperates with the lifting and placing component to clamp the microneedle patch original tape to prevent the microneedle patch original tape from being displaced during pressing. The pressing component then presses the microneedle patch down and inserts it into the insertion position on the arm. After pressing for a period of time, the lifting and positioning component drives the pressing component to rise and reset;

[0014] Pull out the arm: the arm placement component releases the arm from its binding, and the patient pulls the arm out of the arm placement component;

[0015] Patch removal and post-treatment: After a period of time, tear off the microneedle patch from the arm and apply healing gel to the puncture site;

[0016] Rewinding waste tape: After the next patient places his arm inside the arm placement assembly and positions it, the rewinding motors of the rewinding assembly on the left and the rewinding assembly on the top box rotate forward. The rewinding assembly on the left side of the base box is the adhesive tape rewinding reel, which is used to rewind the adhesive tape, and the rewinding assembly on the top box is the pressing tape rewinding reel, which is used to rewind the pressing tape.

[0017] The interior of the base box is provided with two symmetrically arranged mounting vertical plates, the upper end of the base box is provided with an avoidance slide hole, and two support frames are fixed to the upper end of the base box, and tensioning rollers are rotatably provided on the support frames. Tape holes are provided on the left and right sides of the base box, and the support frames are located above the tape holes on the same side. A control button is provided on the top box, and the control button is located on the side of the touch screen. The control button and the visual sensor are electrically connected to the main control board.

[0018] With the above structure, a vertical plate is installed to fix the sliding adjustment component, and the avoidance sliding hole provides a horizontal movement channel for the arm placement component. The bottom of the arm placement component passes through this hole and is connected to the sliding adjustment component. The shape of the hole groove matches the motion trajectory to ensure flexible movement; the support frame cooperates with the tensioning roller to guide and tension the microneedle patch original tape to ensure that the material is flat and wrinkle-free during transmission; the microneedle patch original tape is led out from the right side → bypasses the tensioning roller on the same side → horizontally passes through the working area above the base box → bypasses the tensioning roller on the left → enters the material reel on the left; the tape hole is used to supply the microneedle patch original tape, etc. The channel for roll materials to enter and exit the base box, the right side tape feed hole imports new dressing, and the left side tape feed hole exports waste base paper to prevent the material from rubbing against the box; the control button and the physical button for emergency stop / quick start and stop serve as redundant control of the touch screen, directly connected to the main control board circuit, and immediately interrupt all moving components when triggered to ensure safe operation; the visual sensor locates the arm and identifies the target area in real time; through image capture and algorithm analysis, the arm position and the coordinates of the area to be processed are determined; the coordinate data is sent to the main control board, and the electrical equipment is dynamically adjusted to achieve precise operation.

[0019] The sliding adjustment assembly includes two symmetrically arranged transverse bases, the two transverse bases are vertically fixed between the two mounting vertical plates, a transverse base frame is vertically fixed to the upper ends of the two transverse bases, two second pulleys are rotatably provided at the upper ends of the transverse base frames, a second transmission belt is provided between the two second pulleys, a second transmission motor is fixed to the lower ends of the transverse base frames, an output shaft of the second transmission motor is fixedly connected to the rotating shaft of one of the second pulleys, a second slide rail is fixed to the upper end of the transverse base frame, a sliding slide is slidably provided on the second slide rail, the sliding slide is fixedly connected to the second transmission belt, a sliding block is fixed to the upper end of the sliding slide, the sliding block is slidably arranged inside the avoidance slide hole, and the sliding block extends upward out of the avoidance slide hole, and the second transmission motor is electrically connected to the main control board.

[0020] With the above structure, the main control board generates a sliding target position instruction according to the coordinates set by the touch screen or feedback from the visual sensor; the main control board sends a pulse signal to the second transmission motor to control its speed, direction and rotation angle; the output shaft of the second transmission motor drives the rotating shaft of one of the second pulleys to rotate, and drives the other second pulley to rotate synchronously through the second transmission belt; the second transmission belt is fixed to the sliding slide, and when the second transmission belt moves, it is forced to push / pull the sliding slide to slide in a straight line along the second slide rail; the sliding slide drives the sliding block to move horizontally in the avoidance slide hole, and the sliding block pushes the arm placement assembly connected above to reach the target position; slide rail guidance: the second slide rail eliminates lateral deviation to ensure that the moving path is a pure straight line; closed-loop control: the main control board feeds back the real-time position through the motor encoder, and dynamically adjusts until the error approaches zero.

[0021] The arm placement assembly includes an arm seat and an air pump. The arm seat is fixed above the sliding block, the arm seat slide is in contact with the upper end of the base box, the air pump is fixed to the upper end of the base box, and an elbow seat and an arm tube are fixed to the upper end of the arm seat. The elbow seat is located at the front side of the arm tube, and an arm half-tube is provided on the rear side of the arm tube and the arm seat. The inner arc wall of the arm half-tube is connected to the inner arc wall of the arm tube, and an inflatable bag is provided inside the arm tube. The inflatable bag is connected to the air outlet end of the air pump by a hose, and the air pump is electrically connected to the main control board.

[0022] With the above structure, the patient extends his forearm into the armrest tube, places his forearm above the armrest half-tube, and presses his elbow against the elbow support. The main control panel starts the air pump, and the gas is injected into the inflatable bag through the hose. The inflatable bag expands and gently presses the arm. Pressure adjustment: The main control panel intelligently controls the inflation volume according to the preset pressure value to avoid overpressure; the inflatable bag maintains low pressure and fixation throughout the process to prevent the arm from shifting due to equipment vibration or operation; after the end, the air pump is exhausted, the inflatable bag contracts and loosens the arm, and the patient removes the arm.

[0023] The lateral adjustment assembly includes two symmetrically arranged mounting seats, the two mounting seats are fixed on the upper rear side of the base box, a lateral base is fixed at the front end of the two mounting seats, two first pulleys are rotatably provided on the front side of the lateral base, a first transmission belt is provided between the two first pulleys, a first transmission motor is fixed on the rear side of the lateral base, an output shaft of the first transmission motor is fixedly connected to the rotating shaft of one of the first pulleys, a first slide rail is fixed on the front side of the lateral base, two lateral slides are slidably provided on the first slide rail, the lateral slide is fixedly connected to the first pulley, and the first transmission motor is electrically connected to the main control board.

[0024] With the above structure, the main control board generates the target tool coordinates according to the touch screen settings or visual sensor feedback; the main control board sends a control signal to the first transmission motor, the output shaft of the first transmission motor drives the rotating shaft of one of the first pulleys to rotate, the first pulley pulls the first transmission belt to circulate, and the belt forces the transverse slide to slide in a straight line along the first slide rail through a fixed point to ensure that there is no deviation in the moving path. The movement of the slide drives the movement of the upper lifting and positioning assembly, and finally the sprayer and the pressing assembly reach the target coordinates.

[0025] The lifting and positioning adjustment component includes a guide base, which is fixed to the front end of the transverse slide at the corresponding position, a lifting motor is fixed to the upper end of the guide base, a lifting screw is rotatably provided on the guide base, and a limit sensor is fixed on the guide base, the output shaft of the lifting motor is fixedly connected to the lifting screw, a lifting slide is slidingly provided on the front side of the guide base, the lifting slide is transmission-connected to the lifting screw, a mounting frame is fixed to the front end of the lifting slide, a quick-release connecting seat is fixed to the lower end of the mounting frame, the lifting motor is electrically connected to the main control board, and the sprayer is detachably arranged under the quick-release connecting seat of one of the lifting and positioning adjustment components.

[0026] With the above structure, the main control board calculates the target height according to the operation type; the output shaft of the lifting motor drives the lifting screw to rotate, and the lifting screw pushes the lifting slide to move vertically. The limit sensor triggers a signal when the lifting slide approaches the upper and lower limits, and the main control board is forced to shut down for protection. The sprayer and the pressing assembly are fixedly installed through the quick-release connector at the corresponding position, and the operation is performed when the lifting slide reaches the target height.

[0027] The pressing assembly includes a pressing rod and a locking cross seat. The pressing rod is detachably arranged below the quick-release connecting seat of another lifting and adjusting assembly. The locking cross seat is detachably arranged on the side of the quick-release connecting seat of another lifting and adjusting assembly. A connecting rod is fixed to the lower end of the locking cross seat. A plurality of compression spring connecting rods are provided at the lower end of the connecting rod. A pressing plate is fixed to the lower end of the plurality of compression spring connecting rods.

[0028] With the above structure, the lifting and positioning assembly drives the pressing rod and the locking cross seat to descend, and the locking cross seat drives several compression spring connecting rods to descend through the connecting rod, thereby driving the pressing plate to descend, and the pressing plate cooperates with the lifting and placing assembly to clamp the microneedle patch original tape. The lifting and positioning assembly continues to press down, and several compression spring connecting rods begin to deform under pressure to prevent the microneedle patch original tape from shaking; the lifting and positioning assembly continues to press down, driving the pressing rod to press the microneedle patch area of ​​the microneedle patch original tape downward, tearing the microneedle patch from the microneedle patch original tape, and stably pressing down the puncture The microneedle patch is inserted into the insertion position on the arm. The main control board controls the lifting and positioning assembly to maintain the position for a period of time, ensuring that the lower surface of the microneedle patch is covered with grooves filled with liquid medicine and tiny needles. The tiny needles will pass through the outermost stratum corneum of the skin and deliver the liquid medicine to the subcutaneous cells of the human body; the lifting and positioning assembly moves up and resets, driving the pressing rod to separate from the upper surface of the microneedle patch, and the microneedle patch remains on the arm. At the same time, it also drives several compression spring connecting rods to move up, and then drives the pressing plate to separate from the original upper surface of the microneedle patch, so that it can be pressed again next time.

[0029] The lifting and placing assembly includes a base, which is fixed at the middle of the upper end of the base box. An electric lifting wire rod is provided at the upper end of the base, and a placing platform is transmitted on the electric lifting wire rod. The electric lifting wire rod is electrically connected to the main control board. A support frame is fixed at the left end of the placing platform, and a tensioning roller is rotatably provided on the support frame. The placing platform is located below the pressing plate.

[0030] With the above structure, the dressing tape path is: loading and unloading rolls, tensioning roller on the right side of the base box, horizontally across the top of the placement platform, tensioning roller on the left end of the placement platform, and material collection roll on the left side. After visual positioning, the main control board starts the electric lifting wire rod to drive the placement platform to the target height. The placement platform is close to the lower surface of the microneedle patch original tape, supporting the microneedle patch original tape, and cooperating with the pressing assembly to clamp the microneedle patch original tape; after pressing is completed, the electric lifting wire rod drives the placement platform to descend and reset.

[0031] The lifting mechanism is a kind of key which is set up in the trunk lid, and the lifting mechanism is a kind of key which is set up in the trunk lid, and the lifting mechanism is a kind of key which makes the lifting mechanism of the lifting mechanism a kind of key which makes the lifting mechanism a kind of key that can be lifted out of the trunk lid.

[0032] Using the above structure, slide the hinge seat to the position suitable for the coil, loosen the locking nut, push the adjustment mounting rod, slide the sliding screw along the arc hole, set the inclination angle of the reel, and then tighten the locking nut to prevent vibration deviation; put the roll of the original tape of the microneedle patch into the reel of the reel assembly on the right, and lead the tape around the tensioning wheel to the working area; the main control board starts the rewinding motor to reverse, release the dressing tape, and the tensioning wheel sags due to gravity, triggering the motor to slow down; at the same time, the rewinding motors of the rewinding assembly on the left and the rewinding assembly on the top box rotate forward to rewind the waste tape.

[0033] A microneedle patch original tape is placed inside the loading and unloading roll, and the microneedle patch original tape consists of a pressing tape placed on the top and an adhesive tape placed on the bottom. A number of patch placement holes are opened on the pressing tape, and microneedle patches are arranged inside the patch placement holes in a micro-connection manner. The microneedle patch original tape is tensioned by the tensioning roller on the right side of the top box and enters the interior of the top box through the tape running hole on the right. After the microneedle patch original tape is separated, the adhesive tape passes through the tensioning roller on the supporting platform, the two tensioning rollers at the upper end of the base box, and the tensioning wheel of the left reel assembly and is connected to the reeling wheel of the left reel assembly; the pressing tape after stamping the microneedle patch passes through the left tape running hole, the tensioning roller on the left side of the top box, and the tensioning wheel of the reeling wheel of the reeling wheel assembly on the top box and is connected to the reeling wheel of the reeling wheel assembly on the top box.

[0034] The adhesive tape below is connected to the reel of the left reel assembly; the upper adhesive tape passes through the tensioning roller on the supporting platform, the two tensioning rollers at the upper end of the base box, the tape hole on the left and the tensioning wheel of the left reel assembly; the upper adhesive tape passes through the tensioning roller on the supporting platform, the two tensioning rollers at the upper end of the base box, the tape hole on the left and the tensioning wheel of the left reel assembly in turn, and is connected to the reel assembly on the left reel assembly in turn; the upper adhesive tape passes through the tensioning roller on the left The tensioning roller with a hole and the left side of the top box and the tensioning wheel of the rewinding and unwinding assembly on the top box are connected to the rewinding and unwinding wheel of the rewinding and unwinding assembly on the top box. The pressing rod is facing one of the patch holes below. At this time, the microneedle patch is located directly above the arm insertion position. The pressing rod applies a vertical downward force to the microneedle patch, and the micro connection point breaks. The microneedle patch detaches from the pressing belt, penetrates the arm and remains on the arm, and then the pressing rod and the pressing plate move up and reset in turn; the adhesive tape continues to move forward and is wound on the rewinding and unwinding wheel of the rewinding and unwinding assembly on the left; the pressing tape continues to move forward and is wound on the rewinding and unwinding wheel of the rewinding and unwinding assembly on the top box, and the next patch hole with a microneedle patch is located directly below the pressing rod.

[0035] A microneedle patch medication application method with an automatic mechanical medication application structure comprises the following steps:

[0036] Step 1: Preliminary Setup: The touch screen serves as the human-machine interface, allowing operators to start the equipment, select programs, set parameters, and monitor status. The main control board receives commands from the touch screen, processes sensor information, and precisely controls all motors and components.

[0037] Step 2: Patch loading and positioning: Place the roll of the microneedle patch tape loaded with the microneedle patch on the reel-up and reel-down assembly on the right side of the base box, and tension the end of the roll of the microneedle patch tape by the tensioning roller on the right side of the top box and pass it through the tape feed hole on the right side into the interior of the top box;

[0038] Step 3: Place the arm: The patient places the arm into the arm placement assembly, which tightens the arm. The visual sensor locates the position of the arm, i.e., the spatial position where the microneedle patch is inserted.

[0039] Step 4: Dynamically adjust the spraying of alcohol for disinfection: the sliding adjustment component drives the arm placement component to adjust its position according to the insertion position, and the lateral adjustment component drives the two lifting and positioning components to move according to the insertion position, so that the arm insertion position is directly below the sprayer, and the lifting and positioning component drives the sprayer to descend and be placed above the insertion position. The spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer, and the sprayer sprays at the insertion position. After the spraying is completed, the lifting and positioning component drives the sprayer to rise and reset;

[0040] Step 5, dynamically adjust the insertion and drug administration: the sliding adjustment component drives the arm placement component to adjust its position according to the insertion position, and the lateral adjustment component drives the two lifting and positioning components to move according to the insertion position, so that the arm insertion position is directly below the pressing component, and at this time the pressing component is directly above the lifting and placing component; the lifting and positioning component drives the pressing component to descend, and the lifting and placing component is lifted and adjusted to a height equal to or higher than the height of the arm insertion position. The pressing component first cooperates with the lifting and placing component to clamp the microneedle patch original tape to prevent the microneedle patch original tape from being displaced during pressing. The pressing component then presses the microneedle patch down and inserts it into the insertion position on the arm. After pressing for a period of time, the lifting and positioning component drives the pressing component to rise and reset;

[0041] Step 6: Pull out the arm: The arm placement assembly releases the arm from its binding, and the patient pulls the arm out of the arm placement assembly;

[0042] Step 7: Patch removal and post-processing: After a period of time, tear off the microneedle patch from the arm and apply healing gel to the puncture site;

[0043] Step 8. Rewinding the waste tape: After the next patient places his arm inside the arm placement assembly and positions it, the rewinding and unrewinding assembly on the left side of the base box is the adhesive tape rewinding reel, which is used to rewind the adhesive tape, and the rewinding and unrewinding assembly on the top box is the pressing tape rewinding reel, which is used to rewind the pressing tape. The two rewinding and unrewinding assemblies work simultaneously to rewind the waste tape.

[0044] Compared with the existing technology, the automatic mechanical drug dispensing structure and drug dispensing method for microneedle patch drug dispensing have the following advantages:

[0045] The microneedle patch is accurately positioned through the visual sensor + linkage system to ensure that the microneedle accurately penetrates the target point;

[0046] The pressing assembly cooperates with the lifting and placing assembly to ensure stable clamping of the microneedle patch tape to prevent the microneedle patch tape from shifting during pressing;

[0047] The microneedle patch is carried by three reel-and-roll components, with the original microneedle patch tape consisting of a pressing tape placed on top and an adhesive tape placed on the bottom. The entire process from alcohol spraying to patch pressing is automated, eliminating hand contamination and achieving high efficiency.

[0048] Three rewinding and unwinding components manage the original tape, waste adhesive tape, and waste lamination tape respectively, achieving synchronous unwinding and rewinding to avoid material jamming or tearing;

[0049] Microneedle integrity is guaranteed: the stamping transfer pressing rod is embedded in the patch hole, applying vertical shear force, and the microneedle breakage rate is low;

[0050] The intelligent rewinding system recycles waste tape simultaneously and the working surface automatically resets;

[0051] The arm placement component stably places and binds the arm, adapts to different arm circumferences, and cooperates with the sliding adjustment component to drive the arm to move and accurately locate the insertion position of the arm;

[0052] The lifting and positioning assembly cooperates with the quick release of the sprayer, and the lifting and positioning assembly cooperates with the quick release of the pressing rod, supporting quick release and high operating efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 It is a schematic diagram of the upper three-dimensional structure of the pesticide application structure in the present invention.

[0054] Figure 2 It is a schematic diagram of the lower three-dimensional structure of the pesticide application structure in the present invention.

[0055] Figure 3 It is a schematic structural diagram of the drug application structure of the present invention when it is cut open.

[0056] Figure 4 It is a structural schematic diagram of some components of the pesticide dispensing structure in the present invention.

[0057] Figure 5 It is a structural schematic diagram of the drug dispensing structure of the present invention when it is in the microneedle patch belt conveying state.

[0058] Figure 6 It is a schematic diagram of the front three-dimensional structure of the drug dispensing structure of the present invention when the microneedle patch is dispensing the drug.

[0059] Figure 7 It is a schematic diagram of the rear three-dimensional structure of the drug application structure of the present invention when the microneedle patch is applying the drug.

[0060] Figure 8 It is a structural schematic diagram of the sliding adjustment component and the arm placement component in the present invention.

[0061] Figure 9 It is a structural schematic diagram of the rewinding and unwinding assembly in the present invention.

[0062] Figure 10 It is a schematic flow diagram of the pesticide application method of the present invention.

[0063] In the figure, 1. base box; 2. arm placement assembly; 3. top box; 4. control button; 5. rewinding assembly; 6. touch screen; 7. sliding adjustment assembly; 8. visual sensor; 9. lifting and positioning assembly; 10. lateral adjustment assembly; 11. lifting and placing assembly; 12. pressing assembly; 13. sprayer; 14. microneedle patch; 15. pressing belt; 16. patch placement hole; 17. support frame; 18. adhesive tape; 19. tensioning roller; 20. base; 21. electric lifting wire rod; 22. pressing rod; 23. placing platform; 24. pressing plate; 25. pressing spring connecting rod; 26. connecting rod; 27. locking cross seat; 28. quick release connecting seat; 29. ​​mounting frame; 30. first pulley; 31. first transmission belt; 32. first transmission motor; 3 3. Lifting motor; 34. Lifting slide; 35. Guide base; 36. Transverse base; 37. First slide rail; 38. Transverse slide; 39. Mounting seat; 40. Lifting screw; 41. Limit sensor; 42. Transverse base; 43. Second transmission motor; 44. Transverse base; 45. Second pulley; 46. Second transmission belt; 47. Second slide rail; 48. Sliding block; 49. Arm support seat; 50. Elbow support seat; 51. Inflatable bag; 52. Arm tube; 53. Arm half tube; 54. Sliding slide; 55. Articulated seat; 56. Adjusting mounting rod; 57. Sliding screw; 58. Motor seat; 59. Tensioning pulley; 60. Take-up motor; 61. Take-up and unwinding reel; 62. Side stand; 63. Avoidance slide hole; 64. Mounting plate; 65. Main control board. DETAILED DESCRIPTION

[0064] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solutions of the present invention, but the present invention is not limited to these embodiments.

[0065] like Figures 1-9As shown, the automatic mechanical dispensing structure for microneedle patch dispensing includes a base box 1 and a top box 3 arranged on the upper and rear side of the base box 1, the top box 3 is located above the base box 1, and a sliding adjustment component 7 is provided inside the base box 1. The upper end of the sliding adjustment component 7 is provided with an arm placement component 2, the arm placement component 2 is located above the base box 1 and the arm placement component 2 is located below the top box 3, a medical alcohol box, a lateral adjustment component 10, a lifting and placing component 11 and two symmetrically arranged reeling components 5 are provided above the base box 1, and a reeling component 5 is provided above the top box 3. The reeling component 5 on the right side of the base box 1 is a material loading and unloading reel, and the reeling component 5 on the left side of the base box 1 is an adhesive tape reel. The reel assembly 5 on the top box 3 is a pressing belt reel, and the lateral adjustment assembly 10 is driven by two lifting and positioning assemblies 9, one of which is provided with a sprayer 13, and a spray pump is provided between the sprayer 13 and the medical alcohol tank. The other lifting and positioning assembly 9 is provided with a pressing assembly 12, and the pressing assembly 12 is located above the lifting and placing assembly 11. The lifting and positioning assembly 9, the lateral adjustment assembly 10, the lifting and placing assembly 11, the pressing assembly 12 and the sprayer 13 are all located inside the top box 3. A touch screen 6 and a main control board 65 are provided on the inner top of the top box 3. The touch screen 6 is flush with the top slope of the top box 3, and a number of visual sensors 8 are provided at the lower end and inside of the top box 3.

[0066] Preliminary setup: The touch screen 6 is the human-machine interface, through which the operator starts the device, selects programs, sets parameters (such as disinfection position, pressing force, movement distance, etc.), and monitors the status; the main control board 65 is the brain of the device, receiving instructions from the touch screen 6, processing sensor information, and precisely controlling all motors and components;

[0067] Patch loading and positioning: Place the roll of the microneedle patch tape containing the microneedle patch 14 into the reel assembly 5 on the right side of the base box 1, and extend the end of the roll of the microneedle patch tape into the interior of the top box 3;

[0068] Arm placement: The patient extends his arm into the arm placement component 2, which tightens the arm. The visual sensor 8 locates the position of the arm, i.e., the spatial position where the microneedle patch 14 is inserted.

[0069] Dynamic adjustment of spraying alcohol disinfection: The sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, and the lateral adjustment component 10 drives the two lifting and positioning components 9 to move according to the insertion position, so that the arm insertion position is directly below the sprayer 13, and the lifting and positioning component 9 drives the sprayer 13 to descend and be placed above the insertion position. The spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer 13, and the sprayer 13 sprays at the insertion position. After the spraying is completed, the lifting and positioning component 9 drives the sprayer 13 to rise and reset;

[0070] Dynamic adjustment of insertion and drug administration: the sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, and the lateral adjustment component 10 drives the two lifting and positioning components 9 to move according to the insertion position, so that the arm insertion position is located directly below the pressing component 12, and at this time the pressing component 12 is located directly above the lifting and placing component 11; the lifting and positioning component 9 drives the pressing component 12 to descend, and the lifting and placing component 11 is lifted and adjusted to a height equal to or higher than the height of the arm insertion position, the pressing component 12 first cooperates with the lifting and placing component 11 to clamp the microneedle patch original tape to prevent the microneedle patch original tape from being displaced during pressing, and the pressing component 12 then presses the microneedle patch 14 down to insert it into the insertion position on the arm. After pressing for a period of time, the lifting and positioning component 9 drives the pressing component 12 to rise and reset;

[0071] Pull out the arm: the arm placement component 2 releases the arm from being tied, and the patient pulls the arm out of the arm placement component 2;

[0072] Patch removal and post-treatment: After a period of time, the microneedle patch 14 is torn off from the arm, and a healing gel may be applied to the puncture site;

[0073] Rewinding waste tape: After the next patient places his arm inside the arm placement component 2 and positions it, the rewinding motor 60 of the rewinding component 5 on the left and the rewinding component 5 on the top box 3 rotate forward. The rewinding component 5 on the left side of the base box 1 is the adhesive tape rewinding reel, which is used to rewind the adhesive tape 18, and the rewinding component 5 on the top box 3 is the pressing tape rewinding reel, which is used to rewind the pressing tape 15.

[0074] Two symmetrically arranged mounting vertical plates 64 are provided inside the base box 1, an avoidance slide hole 63 is provided at the upper end of the base box 1, two support frames 17 are fixed at the upper end of the base box 1, and tensioning rollers 19 are rotatably provided on the support frames 17. Belt holes are provided on the left and right sides of the base box 1, and the support frames 17 are located above the belt holes on the same side. A control button 4 is provided on the top box 3, and the control button 4 is located on the side of the touch screen 6. The control button 4 and the visual sensor 8 are electrically connected to the main control board 65.

[0075] The vertical plate 64 is installed to fix the sliding adjustment component 7, and the sliding hole 63 is avoided to provide a horizontal movement channel for the arm placement component 2. The bottom of the arm placement component 2 is connected to the sliding adjustment component 7 through this hole. The shape of the hole groove matches the motion trajectory to ensure flexible movement; the support frame 17 cooperates with the tensioning roller 19 to guide and tension the microneedle patch original tape to ensure that the material is flat and wrinkle-free during transmission; the microneedle patch original tape is led out from the right side (loading and unloading roll) → bypasses the tensioning roller 19 on the same side → horizontally passes through the working area above the base box → bypasses the tensioning roller 19 on the left → enters the left material collection roll; the tape hole is used for the microneedle patch original tape, etc. The channel for roll materials to enter and exit the base box, the right side tape hole is used to import new dressings, and the left side tape hole is used to export waste base paper to avoid material friction with the box; the control button 4, the physical button for emergency stop / quick start and stop, serves as a redundant control of the touch screen, and is directly connected to the main control board 65 circuit. When triggered, all moving components are immediately interrupted to ensure safe operation; the visual sensor 8 locates the arm and identifies the target area (such as the wound / disinfection area) in real time; through image capture and algorithm analysis, the arm position and the coordinates of the area to be processed are determined; the coordinate data is sent to the main control board 65, and the electrical equipment is dynamically adjusted to achieve precise operation.

[0076] The sliding adjustment assembly 7 includes two symmetrically arranged transverse bases 42, and the two transverse bases 42 are vertically fixed between the two mounting vertical plates 64. A transverse base frame 44 is vertically fixed to the upper ends of the two transverse bases 42. Two second pulleys 45 are rotatably provided on the upper ends of the transverse base frames 44. A second transmission belt 46 is provided between the two second pulleys 45. A second transmission motor 43 is fixed to the lower end of the transverse base frame 44. The output shaft of the second transmission motor 43 is fixedly connected to the rotating shaft of one of the second pulleys 45. A second slide rail 47 is fixed to the upper end of the transverse base frame 44. A sliding slide 54 is slidingly provided on the second slide rail 47. The sliding slide 54 is fixedly connected to the second transmission belt 46. A sliding block 48 is fixed to the upper end of the sliding slide 54. The sliding block 48 is slidably arranged inside the avoidance slide hole 63, and the sliding block 48 extends upward out of the avoidance slide hole 63. The second transmission motor 43 is electrically connected to the main control board 65.

[0077] The main control board 65 generates a sliding target position instruction based on the coordinates set by the touch screen 6 or feedback from the visual sensor 8; the main control board 65 sends a pulse signal to the second transmission motor 43 to control its speed, direction and rotation angle; the output shaft of the second transmission motor 43 drives the rotating shaft of one of the second pulleys 45 to rotate, and drives the other second pulley 45 to rotate synchronously through the second transmission belt 46; the second transmission belt 46 is fixed to the sliding slide 54, and when the second transmission belt 46 moves, it forces the sliding slide 54 to push / pull the sliding slide 54 to slide linearly along the second slide rail 47; the sliding slide 54 drives the sliding block 48 to move horizontally in the avoidance slide hole 63, and the sliding block 48 pushes the arm placement component 2 connected above to reach the target position; slide rail guidance: the second slide rail 47 eliminates lateral deviation to ensure that the moving path is a pure straight line; closed-loop control: the main control board 65 feeds back the real-time position through the motor encoder and dynamically adjusts until the error approaches zero.

[0078] The arm placement assembly 2 includes an arm placement seat 49 and an air pump. The arm placement seat 49 is fixed above the sliding block 48. The slide of the arm placement seat 49 is in contact with the upper end of the base box 1. The air pump is fixed to the upper end of the base box 1. The upper end of the arm placement seat 49 is fixed with an elbow seat 50 and an arm placement tube 52. The elbow seat 50 is located on the front side of the arm placement tube 52. The arm placement tube 52 and the arm placement seat 49 are provided with an arm placement half-tube 53 on the rear side. The inner arc wall of the arm placement half-tube 53 is connected to the inner arc wall of the arm placement tube 52. An air bag 51 is provided inside the arm placement tube 52. The air bag 51 is connected to the air outlet end of the air pump by a hose. The air pump is electrically connected to the main control board 65.

[0079] The patient extends his forearm into the armrest tube 52, places his forearm on the armrest half-tube 53, and presses his elbow against the elbow support 50. The main control panel 65 starts the air pump, and the gas is injected into the air bag 51 through the hose. The air bag 51 expands and gently presses the arm. Pressure adjustment: the main control panel 65 intelligently controls the inflation volume according to the preset pressure value (such as 10-30kPa) to avoid overpressure; the air bag 51 maintains low pressure and fixation throughout the process to prevent the arm from shifting due to equipment vibration or operation; after completion, the air pump is exhausted, the air bag 51 contracts and loosens the arm, and the patient removes the arm.

[0080] The lateral adjustment assembly 10 includes two symmetrically arranged mounting seats 39, and the two mounting seats 39 are fixed to the upper rear side of the base box 1. The front ends of the two mounting seats 39 are fixed with a lateral base 36. The front side of the lateral base 36 is rotatably provided with two first pulleys 30, and a first transmission belt 31 is provided between the two first pulleys 30. The rear side of the lateral base 36 is fixed with a first transmission motor 32, and the output shaft of the first transmission motor 32 is fixedly connected to the rotating shaft of one of the first pulleys 30. The front side of the lateral base 36 is fixed with a first slide rail 37, and two lateral slides 38 are slidingly provided on the first slide rail 37. The lateral slide 38 is fixedly connected to the first pulley 30, and the first transmission motor 32 is electrically connected to the main control board 65.

[0081] The main control board 65 generates the target tool coordinates according to the touch screen settings or the feedback from the visual sensor 8; the main control board 65 sends a control signal to the first transmission motor 32, and the output shaft of the first transmission motor 32 drives the rotating shaft of one of the first pulleys 30 to rotate, and the first pulley 30 pulls the first transmission belt 31 to circulate, and the belt forces the transverse slide 38 to slide in a straight line along the first slide rail 37 through a fixed point to ensure that there is no deviation in the moving path. The movement of the slide drives the upper lifting and positioning assembly 9 to move, and finally the sprayer 13 and the pressing assembly 12 reach the target coordinates.

[0082] The lifting and positioning adjustment component 9 includes a guide base 35, which is fixed to the front end of the transverse slide 38 at the corresponding position. A lifting motor 33 is fixed to the upper end of the guide base 35. A lifting screw 40 is rotatably provided on the guide base 35. A limit sensor 41 is fixed on the guide base 35. The output shaft of the lifting motor 33 is fixedly connected to the lifting screw 40. A lifting slide 34 is slidingly provided on the front side of the guide base 35. The lifting slide 34 is transmission-connected to the lifting screw 40. A mounting frame 29 is fixed to the front end of the lifting slide 34. A quick-release connecting seat 28 is fixed to the lower end of the mounting frame 29. The lifting motor 33 is electrically connected to the main control board 65. The sprayer 13 is detachably arranged under the quick-release connecting seat 28 of one of the lifting and positioning adjustment components 9.

[0083] The main control board 65 calculates the target height according to the operation type (spraying / pressing) (such as the spraying distance from the skin is 5 cm, and the pressing distance is 0 cm); the output shaft of the lifting motor 33 drives the lifting screw 40 to rotate, and the lifting screw 40 pushes the lifting slide 34 to move vertically. The limit sensor 41 triggers a signal when the lifting slide 34 approaches the upper and lower limits, and the main control board 65 forces a shutdown protection. The sprayer 13 and the pressing assembly 12 are fixedly installed by the quick-release connecting seat 28 at the corresponding position, and the operation is performed when the lifting slide 34 reaches the target height.

[0084] The pressing assembly 12 includes a pressing rod 22 and a locking cross seat 27. The pressing rod 22 is detachably arranged below the quick-release connecting seat 28 of another lifting and adjusting assembly 9. The locking cross seat 27 is detachably arranged on the side of the quick-release connecting seat 28 of another lifting and adjusting assembly 9. A connecting rod 26 is fixed to the lower end of the locking cross seat 27. A plurality of compression spring connecting rods 25 are provided at the lower end of the connecting rod 26. A pressing plate 24 is fixed to the lower end of the plurality of compression spring connecting rods 25.

[0085] The lifting and positioning assembly 9 drives the pressing rod 22 and the engaging cross seat 27 to descend, and the engaging cross seat 27 drives the plurality of compression spring connecting rods 25 to descend through the connecting rod 26, thereby driving the pressing plate 24 to descend, and the pressing plate 24 cooperates with the lifting and placing assembly 11 to clamp the microneedle patch original tape, and the lifting and positioning assembly 9 continues to press down, and the plurality of compression spring connecting rods 25 begin to deform under pressure to prevent the microneedle patch original tape from shaking; the lifting and positioning assembly 9 continues to press down, driving the pressing rod 22 to press the microneedle patch 14 area of ​​the microneedle patch original tape downward, tearing the microneedle patch 14 from the microneedle patch original tape, and stabilizing The insertion position on the arm is pressed down, and the main control board 65 controls the lifting and positioning assembly 9 to maintain the position for a period of time, ensuring that the lower surface of the microneedle patch 14 is covered with grooves filled with liquid medicine and tiny needles. The tiny needles will pass through the outermost stratum corneum of the skin and deliver the liquid medicine to the subcutaneous cells of the human body; the lifting and positioning assembly 9 moves up and resets, driving the pressing rod 22 to separate from the upper surface of the microneedle patch 14, and the microneedle patch 14 remains on the arm, and at the same time drives several compression spring connecting rods 25 to move up, and then drives the pressing plate 24 to separate from the upper surface of the original microneedle patch, so as to facilitate the next pressing.

[0086] The lifting and placing assembly 11 includes a base 20, which is fixed at the middle of the upper end of the base box 1. An electric lifting wire rod 21 is provided at the upper end of the base 20, and a placing platform 23 is transmitted on the electric lifting wire rod 21. The electric lifting wire rod 21 is electrically connected to the main control board 65. A support frame 17 is fixed at the left end of the placing platform 23, and a tensioning roller 19 is rotatably provided on the support frame 17. The placing platform 23 is located below the pressing plate 24.

[0087] Dressing tape path: loading and unloading rolls, tensioning roller on the right side of base box 1, horizontally across the top of the receiving platform 23, tensioning roller 19 at the left end of the receiving platform, material collection roll on the left, visual positioning, main control board 65 starts the electric lifting wire rod 21, driving the receiving platform 23 to rise to the target height, the receiving platform 23 is close to the lower surface of the microneedle patch original tape, supporting the microneedle patch original tape, and cooperating with the pressing assembly 12 to clamp the microneedle patch original tape; after pressing is completed, the electric lifting wire rod 21 drives the receiving platform 23 to descend and reset.

[0088] The reel assembly 5 includes an articulated seat 55 and two symmetrically arranged side frames 62. The articulated seat 55 is slidably arranged on the upper end of the base box 1 or the upper end of the top box 3. The two side frames 62 are fixed to the upper end of the base box 1 or the upper end of the top box 3. An arc hole is opened on the side frames 62. The upper end of the articulated seat 55 is hinged with a position adjustment mounting rod 56. Both ends of the position adjustment mounting rod 56 are fixed with a sliding screw 57. The sliding screw 57 is slidably arranged on the side frames on the same side. Inside the arc-shaped hole of the frame 62, the sliding screw 57 is threaded with a locking nut, the adjusting mounting rod 56 is fixed with a motor seat 58, the motor seat 58 is fixed with a take-up motor 60, and the output shaft of the take-up motor 60 is fixed with a tensioning wheel 59. The side of the adjusting mounting rod 56 is provided with a take-up reel 61 for rotation, and a pulley pair is provided between the output shaft of the take-up motor 60 and the rotating shaft of the take-up reel 61. The take-up reel 61 is located at the upper end of the tensioning wheel 59.

[0089] Slide the hinge seat 55 to the position suitable for the coil, loosen the locking nut, push the adjustment mounting rod 56, the sliding screw 57 slides along the arc hole, set the inclination angle of the reel 61, and then tighten the locking nut to prevent vibration deviation; put the roll of the microneedle patch original tape into the reel 61 of the reel assembly 5 on the right, and lead the tape around the tensioning wheel 59 to the working area; the main control board 65 starts the rewinding motor 60 to reverse, release the dressing tape, and the tensioning wheel 59 sags due to gravity, triggering the motor to slow down (to prevent excessive looseness); at the same time, the rewinding motor 60 of the rewinding assembly 5 on the left and the rewinding assembly 5 on the top box 3 rotates forward to rewind the waste tape.

[0090] The microneedle patch tape is placed inside the feeding and unloading roll. The microneedle patch tape consists of a pressing tape 15 placed on the top and an adhesive tape 18 placed on the bottom. The pressing tape 15 is provided with a number of patch holes 16 evenly spaced at equal intervals. The patch holes 16 are each provided with microneedle patches 14 in a micro-connected manner. The microneedle patch tape is tensioned by the tensioning roller 19 on the right side of the top box 3 and enters the interior of the top box 3 through the tape hole on the right. The adhesive tape after the microneedle patch tape is separated 18 passes through the tensioning roller 19 on the supporting platform 23, the two tensioning rollers 19 on the upper end of the base box 1, and the tensioning wheel 59 of the left side rewinding assembly 5 and is connected to the rewinding wheel 61 of the left side rewinding assembly 5; the pressing belt 15 after punching the microneedle patch 14 passes through the tape feed hole on the left, the tensioning roller 19 on the left side of the top box 3, and the tensioning wheel 59 of the rewinding assembly 5 on the top box 3 and is connected to the rewinding wheel 61 of the rewinding assembly 5 on the top box 3.

[0091] The microneedle patch original tape is composed of a pressing tape 15 placed on the top and an adhesive tape 18 placed on the bottom. The adhesive tape 18 is adhered to the lower end surface of the pressing tape 15. The adhesive tape 18 is used to protect the microneedle patch 14. The pressing tape 15 carries the microneedle patch 14 and moves to the top of the supporting platform 23. The lifting and placing assembly 11 is lifted to place the microneedle patch original tape (which is in contact with the lower end surface of the adhesive tape 18). The pressing plate 24 is pressed down and cooperates with the lifting and placing assembly 11 to press the microneedle patch original tape. The microneedle patch original tape is separated at the pressing plate 24. The adhesive tape 18 below passes through the tensioning roller 19 on the supporting platform 23, the two tensioning rollers 19 at the upper end of the base box 1, the tape running hole on the left and the tensioning wheel 59 of the left rewinding assembly 5 and is connected to the rewinding wheel 61 of the left rewinding assembly 5; the pressing tape 15 above passes through the left in turn. The tape hole, the tensioning roller 19 on the left side of the top box 3 and the tensioning wheel 59 of the rewinding and unwinding assembly 5 on the top box 3 are connected to the rewinding and unwinding wheel 61 of the rewinding and unwinding assembly 5 on the top box 3, and the pressing rod 22 is facing one of the patch holes 16 below. At this time, the microneedle patch 14 is located directly above the arm insertion position, and the pressing rod 22 applies a vertical downward force to the microneedle patch 14, the micro connection point breaks, the microneedle patch 14 breaks away from the pressing tape 15, penetrates the arm and remains on the arm, and then the pressing rod 22 and the pressing plate 24 move up and reset in sequence; the adhesive tape 18 continues to move forward and is wound on the rewinding and unwinding wheel 61 of the rewinding and unwinding assembly 5 on the left; the pressing tape 15 continues to move forward and is wound on the rewinding and unwinding wheel 61 of the rewinding and unwinding assembly 5 on the top box 3, and the next patch hole 16 with the microneedle patch 14 is located directly below the pressing rod 22.

[0092] like Figure 10 As shown, the microneedle patch dispensing method of the automatic mechanical dispensing structure has the following steps:

[0093] Step 1: Preliminary setup: The touch screen 6 is the human-machine interface, through which the operator starts the device, selects programs, sets parameters, and monitors status; the main control board 65 receives instructions from the touch screen 6, processes sensor information, and precisely controls all motors and components;

[0094] Step 2: Patch loading and positioning: Place the roll of the microneedle patch tape loaded with the microneedle patch 14 on the reel-up reel 61 of the reel-up reel assembly 5 on the right side of the base box 1, and tension the end of the microneedle patch tape by the tensioning roller 19 on the right side of the top box 3 and enter the interior of the top box 3 through the tape feed hole on the right side;

[0095] Step 3: Place the arm: The patient extends the arm into the arm placement assembly 2, which tightens the arm. The visual sensor 8 locates the position of the arm, i.e., the spatial position where the microneedle patch 14 is inserted.

[0096] Step 4: Dynamically adjust the spraying of alcohol for disinfection: the sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, and the lateral adjustment component 10 drives the two lifting and positioning components 9 to move according to the insertion position, so that the arm insertion position is directly below the sprayer 13, and the lifting and positioning component 9 drives the sprayer 13 to descend and be placed above the insertion position. The spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer 13, and the sprayer 13 sprays at the insertion position. After the spraying is completed, the lifting and positioning component 9 drives the sprayer 13 to rise and reset;

[0097] Step five, dynamically adjust the insertion and drug administration: the sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, and the lateral adjustment component 10 drives the two lifting and positioning components 9 to move according to the insertion position, so that the arm insertion position is located directly below the pressing component 12, and at this time the pressing component 12 is located directly above the lifting and placing component 11; the lifting and positioning component 9 drives the pressing component 12 to descend, and the lifting and placing component 11 is lifted and adjusted to a height equal to or higher than the height of the arm insertion position, the pressing component 12 first cooperates with the lifting and placing component 11 to clamp the microneedle patch original belt to prevent the microneedle patch original belt from being displaced during pressing, and the pressing component 12 then presses the microneedle patch 14 down to insert it into the insertion position on the arm. After pressing for a period of time, the lifting and positioning component 9 drives the pressing component 12 to rise and reset;

[0098] Step 6: Pull out the arm: The arm placement component 2 releases the arm from being tied tightly, and the patient pulls the arm out of the arm placement component 2;

[0099] Step 7: Patch removal and post-processing: After a period of time, the microneedle patch 14 is torn off the arm, and a healing gel may be applied to the puncture site;

[0100] Step eight, winding up the waste tape: After the next patient places his arm inside the arm placement component 2 and positions it, the reel assembly 5 on the left side of the base box 1 is the adhesive tape reel, used to wind up the adhesive tape 18, and the reel assembly 5 on the top box 3 is the pressing tape reel, used to wind up the pressing tape 15. The two reel assemblies 5 work simultaneously to wind up the waste tape.

[0101] Working principle of the present invention: Preliminary setup: The touch screen 6 is the human-machine interface, through which the operator starts the device, selects a program, sets parameters (such as disinfection position, pressing force, moving distance, etc.), and monitors the status; the main control board 65 receives instructions from the touch screen 6, processes sensor information, and accurately controls all motors and components;

[0102] Patch loading and positioning: The roll of the microneedle patch tape with the microneedle patch 14 is placed on the rewinding and unwinding reel 61 of the rewinding and unwinding reel assembly 5 on the right side of the base box 1, and the end of the roll of the microneedle patch tape is tensioned by the tensioning roller 19 on the right side of the top box 3 and enters the interior of the top box 3 through the tape run hole on the right; the microneedle patch tape is separated at the pressing plate 24, and the adhesive tape 18 below passes through the tensioning roller 19 on the supporting platform 23, the two tensioning rollers 19 at the upper end of the base box 1, the tape run hole on the left and the tensioning wheel 59 of the rewinding and unwinding reel assembly 5 on the left in turn, and is connected to the rewinding and unwinding reel 61 of the rewinding and unwinding reel assembly 5 on the left; the pressing tape 15 above passes through the tape run hole on the left, the tensioning roller 19 on the left side of the top box 3 and the tensioning wheel 59 of the rewinding and unwinding reel assembly 5 on the top box 3 in turn, and is connected to the rewinding and unwinding reel 61 of the rewinding and unwinding reel assembly 5 on the top box 3;

[0103] Arm placement: The patient extends his or her forearm into the arm placement cylinder 52, places the forearm on the arm placement half cylinder 53, and presses the elbow against the elbow support 50. The main control board 65 activates the air pump, and gas is injected into the air bag 51 through the hose. The air bag 51 expands and gently presses the arm. The visual sensor 8 locates the position of the arm, that is, the spatial position where the microneedle patch 14 is inserted;

[0104] Dynamic adjustment of spraying alcohol disinfection: the sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, that is, the main control board 65 sends a pulse signal to the second transmission motor 43 to control its speed, direction and rotation angle; the output shaft of the second transmission motor 43 drives the rotating shaft of one of the second pulleys 45 to rotate, and drives the other second pulley 45 to rotate synchronously through the second transmission belt 46; the second transmission belt 46 is fixed to the sliding slide 54, and when the second transmission belt 46 moves, it is forced to push / pull the sliding slide 54 to slide linearly along the second slide rail 47; the sliding slide 54 drives the sliding block 48 to move horizontally in the avoidance slide hole 63, and the sliding block 48 pushes the arm placement component 2 connected above to reach the target position; the lateral adjustment component 10 drives according to the insertion position The two lifting and positioning components 9 move, that is, the main control board 65 sends a control signal to the first transmission motor 32, and the output shaft of the first transmission motor 32 drives the rotating shaft of one of the first pulleys 30 to rotate, and the first pulley 30 pulls the first transmission belt 31 to circulate, and the belt forcibly pushes / pull the transverse slide 38 to slide in a straight line along the first slide rail 37 through a fixed point to ensure that the moving path has no deviation. The movement of the slide drives the upper lifting and positioning component 9 to move, so that the position where the arm is inserted is directly below the sprayer 13, and the lifting and positioning component 9 drives the sprayer 13 to descend and be placed above the insertion position. The spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer 13, and the sprayer 13 sprays at the insertion position. After the spraying is completed, the lifting and positioning component 9 drives the sprayer 13 to rise and reset;

[0105] Dynamic adjustment of insertion and drug administration: the sliding adjustment component 7 drives the arm placement component 2 to adjust its position according to the insertion position, that is, the main control board 65 sends a pulse signal to the second transmission motor 43 to control its speed, direction and rotation angle; the output shaft of the second transmission motor 43 drives the rotating shaft of one of the second pulleys 45 to rotate, and drives the other second pulley 45 to rotate synchronously through the second transmission belt 46; the second transmission belt 46 is fixed to the sliding slide 54, and when the second transmission belt 46 moves, it is forced to push / pull the sliding slide 54 to slide linearly along the second slide rail 47, and the lateral adjustment component 10 drives the two lifting and positioning components 9 to move according to the insertion position, that is The main control board 65 sends a control signal to the first transmission motor 32. The output shaft of the first transmission motor 32 drives the rotating shaft of one of the first pulleys 30 to rotate. The first pulley 30 pulls the first transmission belt 31 to circulate. The belt pushes / pull the transverse slide 38 to slide in a straight line along the first slide rail 37 through a fixed point to ensure that there is no deviation in the moving path. The movement of the slide drives the upper lifting and positioning assembly 9 to move, so that the position where the arm is inserted is directly below the pressing assembly 12, and at this time the pressing assembly 12 is directly above the lifting and placing assembly 11; the lifting and positioning assembly 9 drives the pressing assembly 12 to descend, that is, the lifting and positioning assembly 9 drives the pressing rod 22 and the locking rod 22. The horizontal seat 27 descends, and the engaging horizontal seat 27 drives the several compression spring connecting rods 25 to descend through the connecting rod 26, thereby driving the pressing plate 24 to descend, and the lifting and placing assembly 11 is lifted and adjusted to a height equal to or higher than the height of the position where the arm is inserted, and the main control board 65 starts the electric lifting wire rod 21 to drive the placing platform 23 to rise to the target height, and the placing platform 23 is close to the lower surface of the microneedle patch original tape to support the microneedle patch original tape, and the pressing assembly 12 first cooperates with the lifting and placing assembly 11 to clamp the microneedle patch original tape to prevent the microneedle patch original tape from being displaced during pressing, and the pressing assembly 12 then presses the microneedle patch 14 downward, that is, the lifting and positioning assembly 9 continues to press downward, and several compressions are made. The spring connecting rod 25 begins to deform under pressure to prevent the original tape of the microneedle patch from shaking. The lifting and positioning assembly 9 continues to press down, driving the pressing rod 22 to press the microneedle patch 14 of the original tape of the microneedle patch downward, breaking the micro-connection point, and the microneedle patch 14 is separated from the patch placement hole 16 of the pressing tape 15, and is stably pressed down to insert into the insertion position on the arm; the main control board 65 controls the lifting and positioning assembly 9 to maintain the position for a period of time, ensuring that the lower surface of the microneedle patch 14 is covered with grooves filled with liquid medicine and tiny needles. The tiny needles will penetrate the stratum corneum of the outermost layer of the skin and deliver the liquid medicine to the subcutaneous cells of the human body. After pressing for a period of time, the lifting and positioning assembly 9 drives the pressing assembly 12 to rise and reset;

[0106] Pulling out the arm: the arm placement assembly 2 releases the arm from its binding, i.e. the air pump is exhausted, the air binding bag 51 contracts and loosens the arm, and the patient pulls the arm out of the arm placement assembly 2;

[0107] Patch removal and post-processing: After a period of time, the microneedle patch 14 is torn off from the arm, and a healing gel may be applied to the puncture site;

[0108] Rewinding the waste tape: After the next patient places his arm inside the arm placement component 2 and positions it, the tape rewinding motor 60 of the rewinding component 5 on the left and the rewinding component 5 on the top box 3 rotates forward, driving the adhesive tape 18 to continue moving forward and rewinding on the rewinding wheel 61 of the rewinding component 5 on the left, and at the same time driving the pressing tape 15 to continue moving forward and rewinding on the rewinding wheel 61 of the rewinding component 5 on the top box 3, so that the next patch placement hole 16 with the microneedle patch 14 is located directly below the pressing rod 22.

[0109] In summary, this drug administration method can achieve precise drug administration and safe operation. The microneedle patch 14 is accurately positioned through the visual sensor 8 + linkage system (sliding adjustment component 7 / lateral adjustment component 10 / lifting adjustment component 9), ensuring that the microneedles accurately penetrate the target site.

[0110] The pressing assembly 12 cooperates with the lifting and placing assembly 11 to ensure stable clamping of the microneedle patch tape to prevent the microneedle patch tape from being displaced during pressing;

[0111] The microneedle patch 14 is carried by three reel-and-roll assemblies 5 and is supported by a microneedle patch tape consisting of a pressing tape 15 placed above and an adhesive tape 18 placed below. The entire process of alcohol spraying and patch pressing is automated, eliminating hand contamination and achieving high efficiency.

[0112] The three rewinding and unwinding components 5 manage the original tape (feeding), waste adhesive tape (recycling) and waste pressing tape (recycling) respectively, realizing synchronous unwinding and rewinding, with high tension control accuracy to avoid material jamming or tearing;

[0113] Microneedle integrity is guaranteed: the stamping transfer pressing rod 22 is embedded in the patch hole 16, applying vertical shear force, and the microneedle breakage rate is low;

[0114] The intelligent rewinding system recycles waste tape (pressing tape 15 / adhesive tape 18) simultaneously, and the working surface automatically resets;

[0115] The arm placement component 2 stably places and binds the arm, adapts to different arm circumferences, and cooperates with the sliding adjustment component 7 to drive the arm to move and accurately locate the insertion position of the arm;

[0116] The lifting and positioning component 9 is quickly disassembled with the sprayer 13, and the lifting and positioning component 9 is quickly disassembled with the pressing rod 22, which supports quick disassembly and has high operating efficiency.

[0117] The specific embodiments described herein are merely illustrative of the spirit of the present invention. Persons skilled in the art may make various modifications, additions, or substitutions to the described specific embodiments without departing from the spirit of the present invention or exceeding the scope of the appended claims.

Claims

1. An automatic mechanical drug dispensing structure for microneedle patch drug dispensing, comprising a base box (1) and a top box (3) arranged above and behind the base box (1), characterized in that: The top box (3) is located above the base box (1), a sliding adjustment component (7) is provided inside the base box (1), an arm placement component (2) is provided on the upper end of the sliding adjustment component (7), the arm placement component (2) is located above the base box (1) and the arm placement component (2) is located below the top box (3), a medical alcohol box, a transverse adjustment component (10), a lifting and placing component (11) and two symmetrically arranged reeling components (5) are provided above the base box (1), a reeling and reeling component (5) is provided above the top box (3), the reeling and reeling component (5) on the right side of the base box (1) is a loading and unloading reel, the reeling and reeling component (5) on the left side of the base box (1) is an adhesive tape reel, the reeling and reeling component (5) on the top box (3) is a pressing tape reel, and the transverse The shift adjustment component (10) is provided with two lifting and positioning components (9) for transmission, wherein one lifting and positioning component (9) is provided with a liquid sprayer (13), and a liquid spray pump is provided between the liquid sprayer (13) and the medical alcohol tank. The other lifting and positioning component (9) is provided with a pressing component (12), and the pressing component (12) is located above the lifting and placing component (11). The lifting and positioning component (9), the lateral shift adjustment component (10), the lifting and placing component (11), the pressing component (12) and the liquid sprayer (13) are all located inside the top box (3). The inner top of the top box (3) is provided with a touch screen (6) and a main control board (65), and the touch screen (6) is flush with the top inclined surface of the top box (3). The lower end and the interior of the top box (3) are provided with a plurality of visual sensors (8).

2. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 1, characterized in that: The interior of the base box (1) is provided with two symmetrically arranged mounting vertical plates (64), the upper end of the base box (1) is provided with an avoidance slide hole (63), the upper end of the base box (1) is fixed with two support frames (17), and the support frames (17) are rotatably provided with tensioning rollers (19), the left and right sides of the base box (1) are provided with tape holes, and the support frames (17) are located above the tape holes on the same side, and the top box (3) is provided with a control button (4), and the control button (4) is located on the side of the touch screen (6), and the control button (4) and the visual sensor (8) are both electrically connected to the main control board (65).

3. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 2, characterized in that: The sliding adjustment assembly (7) comprises two symmetrically arranged transverse bases (42), the two transverse bases (42) are vertically fixed between two mounting vertical plates (64), a transverse base frame (44) is vertically fixed to the upper ends of the two transverse bases (42), two second pulleys (45) are rotatably provided on the upper ends of the transverse base frame (44), a second transmission belt (46) is provided between the two second pulleys (45), a second transmission motor (43) is fixed to the lower end of the transverse base frame (44), and an output shaft of the second transmission motor (43) is connected to the upper end of the transverse base frame (44). A rotating shaft of a second pulley (45) is fixedly connected, a second slide rail (47) is fixed to the upper end of the horizontal base frame (44), a sliding slide (54) is slidably provided on the second slide rail (47), the sliding slide (54) and the second transmission belt (46) are fixedly connected, a sliding block (48) is fixed to the upper end of the sliding slide (54), the sliding block (48) is slidably set inside the avoidance slide hole (63), and the sliding block (48) extends upward from the avoidance slide hole (63), and the second transmission motor (43) is electrically connected to the main control board (65).

4. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 3, characterized in that: The arm placement assembly (2) comprises an arm placement seat (49) and an air pump. The arm placement seat (49) is fixed above the sliding block (48). The slideway of the arm placement seat (49) contacts the upper end of the base box (1). The air pump is fixed to the upper end of the base box (1). An elbow support seat (50) and an arm placement tube (52) are fixed to the upper end of the arm placement seat (49). The elbow support seat (50) is located at the front side of the arm placement tube (52). An arm placement half tube (53) is provided at the rear side of the arm placement tube (52) and the arm placement seat (49). The inner arc wall of the arm placement half tube (53) is connected to the inner arc wall of the arm placement tube (52). An air bag (51) is provided inside the arm placement tube (52). The air bag (51) is connected to the air outlet end of the air pump through a hose. The air pump is electrically connected to the main control board (65).

5. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 4, characterized in that: The transverse adjustment assembly (10) includes two symmetrically arranged mounting seats (39), the two mounting seats (39) are fixed to the upper rear side of the base box (1), a transverse base frame (36) is fixed at the front end of the two mounting seats (39), the front side of the transverse base frame (36) is rotatably provided with two first pulleys (30), a first transmission belt (31) is provided between the two first pulleys (30), a first transmission motor (32) is fixed to the rear side of the transverse base frame (36), an output shaft of the first transmission motor (32) is fixedly connected to the rotating shaft of one of the first pulleys (30), a first slide rail (37) is fixed to the front side of the transverse base frame (36), two transverse slides (38) are slidably provided on the first slide rail (37), the transverse slide (38) is fixedly connected to the first pulley (30), and the first transmission motor (32) is electrically connected to the main control board (65).

6. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 5, characterized in that: The lifting and positioning adjustment component (9) includes a guide base (35), the guide base (35) is fixed to the front end of the transverse sliding seat (38) at the corresponding position, a lifting motor (33) is fixed to the upper end of the guide base (35), a lifting screw (40) is rotatably provided on the guide base (35), a limit sensor (41) is fixed on the guide base (35), the output shaft of the lifting motor (33) is fixedly connected to the lifting screw (40), a lifting slide (34) is slidably provided on the front side of the guide base (35), the lifting slide (34) is transmission-connected to the lifting screw (40), a mounting frame (29) is fixed to the front end of the lifting slide (34), a quick-release connecting seat (28) is fixed to the lower end of the mounting frame (29), the lifting motor (33) is electrically connected to the main control board (65), and the sprayer (13) is detachably arranged below the quick-release connecting seat (28) of one of the lifting and positioning adjustment components (9).

7. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 6, characterized in that: The pressing assembly (12) comprises a pressing rod (22) and a clamping cross seat (27), wherein the pressing rod (22) is detachably arranged below a quick-release connecting seat (28) of another lifting and positioning assembly (9), and the clamping cross seat (27) is detachably arranged on the side of the quick-release connecting seat (28) of another lifting and positioning assembly (9), and a connecting rod (26) is fixed to the lower end of the clamping cross seat (27), and a plurality of compression spring connecting rods (25) are provided at the lower end of the plurality of compression spring connecting rods (25), and a pressing plate (26) is fixed to the lower end of the plurality of compression spring connecting rods (25). 4); the lifting and placing assembly (11) includes a base (20), the base (20) is fixed to the middle of the upper end of the base box (1), the upper end of the base (20) is provided with an electric lifting wire rod (21), the electric lifting wire rod (21) is provided with a placing platform (23) for transmission, the electric lifting wire rod (21) is electrically connected to the main control board (65), the left end of the placing platform (23) is fixed with a support frame (17), the support frame (17) is rotatably provided with a tensioning roller (19), and the placing platform (23) is located below the pressing plate (24).

8. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 7, characterized in that: The rewinding and unwinding assembly (5) comprises an articulated seat (55) and two symmetrically arranged side frames (62). The articulated seat (55) is slidably arranged on the upper end of the base box (1) or the upper end of the top box (3). The two side frames (62) are fixed to the upper end of the base box (1) or the upper end of the top box (3). An arc hole is provided on the side frames (62). The upper end of the articulated seat (55) is hinged with a position adjustment mounting rod (56). Both ends of the position adjustment mounting rod (56) are fixed with a sliding screw (57). The sliding screw (57) is slidably arranged on the same side. Inside the arc-shaped hole of the side stand (62), a locking nut is screwed on the sliding screw (57), a motor seat (58) is fixed on the position adjustment mounting rod (56), a take-up motor (60) is fixed on the motor seat (58), a tensioning wheel (59) is fixed on the output shaft of the take-up motor (60), a side portion of the position adjustment mounting rod (56) is provided with a take-up and unwinding wheel (61) for rotation, a pulley pair is provided between the output shaft of the take-up motor (60) and the rotating shaft of the take-up and unwinding wheel (61), and the take-up and unwinding wheel (61) is located at the upper end of the tensioning wheel (59).

9. The automatic mechanical drug dispensing structure for microneedle patch drug dispensing according to claim 8, characterized in that: A microneedle patch tape is placed inside the loading and unloading roll, and the microneedle patch tape consists of a pressing tape (15) placed on the top and an adhesive tape (18) placed on the bottom. The pressing tape (15) is provided with a number of patch holes (16) evenly spaced and evenly distributed. Microneedle patches (14) are arranged inside the patch holes (16) in a micro-connection manner. The microneedle patch tape is tensioned by a tensioning roller (19) on the right side of the top box (3) and enters the interior of the top box (3) through the tape running hole on the right side. After the microneedle patch tape is separated, the adhesive tape (18) passes through the supporting roller (19) in sequence. The tensioning roller (19) on the unloading platform (23), the two tensioning rollers (19) at the upper end of the base box (1), and the tensioning wheel (59) of the left side unwinding and rewinding assembly (5) are connected to the unwinding and rewinding wheel (61) of the left side unwinding and rewinding assembly (5); the pressing tape (15) after punching the microneedle patch (14) passes through the tape running hole on the left side, the tensioning roller (19) on the left side of the top box (3), and the tensioning wheel (59) of the unwinding and rewinding assembly (5) on the top box (3) in sequence, and is connected to the unwinding and rewinding wheel (61) of the unwinding and rewinding assembly (5) on the top box (3).

10. A method for administering medicine using an automatic mechanical drug dispensing structure for microneedle patch administration according to any one of claims 1 to 9, characterized in that: The following steps are required: Step 1, preliminary settings: The touch screen (6) is the human-machine interface, through which the operator starts the device, selects programs, sets parameters, and monitors status; the main control board (65) receives instructions from the touch screen (6), processes sensor information, and accurately controls all motors and components; Step 2, patch loading and positioning: placing the roll of the microneedle patch tape loaded with the microneedle patch (14) on the reel-up reel (61) of the reel-up reel assembly (5) on the right side of the base box (1), and tensioning the end of the roll of the microneedle patch tape by the tensioning roller (19) on the right side of the top box (3) and passing the tape feed hole on the right side into the interior of the top box (3); Step 3, placing the arm: the patient extends the arm into the arm placement component (2), the arm placement component (2) tightens the arm, and the visual sensor (8) locates the position of the arm, that is, locates the spatial position of the microneedle patch (14) inserted; Step 4, dynamically adjusting the spraying alcohol disinfection: the sliding adjustment component (7) drives the arm placement component (2) to adjust its position according to the insertion position, and the lateral adjustment component (10) drives the two lifting and positioning components (9) to move according to the insertion position, so that the arm insertion position is located directly below the sprayer (13), and the lifting and positioning component (9) drives the sprayer (13) to descend and be placed above the insertion position, and the spray pump injects the medical alcohol inside the medical alcohol tank into the sprayer (13), and the sprayer (13) sprays at the insertion position. After the spraying is completed, the lifting and positioning component (9) drives the sprayer (13) to rise and reset; Step 5, dynamically adjusting the insertion and drug administration: the sliding adjustment component (7) drives the arm placement component (2) to adjust its position according to the insertion position, and the lateral adjustment component (10) drives the two lifting and positioning components (9) to move according to the insertion position, so that the insertion position of the arm is located directly below the pressing component (12), and at this time the pressing component (12) is located directly above the lifting and placing component (11); the lifting and positioning component (9) drives the pressing component (12) to descend, and the lifting and placing component (11) is lifted and adjusted to a height equal to or higher than the height of the insertion position of the arm, and the pressing component (12) first cooperates with the lifting and placing component (11) to clamp the original tape of the microneedle patch to prevent the original tape of the microneedle patch from being displaced during pressing, and the pressing component (12) then presses the microneedle patch (14) downward to insert it into the insertion position on the arm. After pressing for a period of time, the lifting and positioning component (9) drives the pressing component (12) to rise and reset; Step 6, pulling out the arm: the arm placement component (2) releases the arm from being tied tightly, and the patient pulls the arm out of the arm placement component (2); Step 7: patch removal and post-processing; After a period of time, the microneedle patch (14) is torn off from the arm, and a healing gel may be applied to the puncture site; Step 8, rewinding the waste tape: After the next patient places his arm inside the arm placement assembly (2) and positions it, the rewinding and unwinding assembly (5) on the left side of the base box (1) is an adhesive tape rewinding roll for rewinding the adhesive tape (18), and the rewinding and unwinding assembly (5) on the top box (3) is a pressing tape rewinding roll for rewinding the pressing tape (15). The two rewinding and unwinding assemblies (5) work simultaneously to rewind the waste tape.

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