Glass reaction kettle for preparing irinotecan hydrochloride injection

Abstract

The invention relates to the technical field of irinotecan hydrochloride injection preparation instruments, and discloses a glass reaction kettle for irinotecan hydrochloride injection preparation, the glass reaction kettle comprises a support bottom plate, a glass reaction kettle assembly is arranged above the support bottom plate, and a heating lantern ring is arranged outside the glass reaction kettle assembly; an adjusting mechanism; and a stirring mechanism. According to the glass reaction kettle for preparing the irinotecan hydrochloride injection, feeding and stirring of the glass reaction kettle body can be flexibly controlled by rotating a first supporting plate and a second supporting plate, and when the first supporting plate moves to the position above a feeding opening, a lifting clamping frame drives a stirrer to descend; a sealing cover plate is connected with a circular convex plate on the descending lifting bracket through a connecting clamping groove, so that a feeding hole is conveniently sealed, a heating lantern ring is convenient for heating an irinotecan hydrochloride injection in a stirring process, water for injection needs to be added in the stirring process, and raw and auxiliary materials are added for stirring and dissolving at a certain temperature under the control.

Description

Technical Field

[0001] The invention relates to the technical field of equipment for preparing irinotecan hydrochloride injection, in particular to a glass reactor for preparing irinotecan hydrochloride injection. Background Art

[0002] Irinotecan hydrochloride is a water-soluble, semisynthetic derivative of camptothecin. Camptothecin specifically binds to topoisomerase I, which induces reversible single-strand breaks, thereby unwinding the DNA double-strand structure. Irinotecan and its active metabolites bind to the topoisomerase I-DNA complex, preventing the reconnection of the broken single strands. Existing studies suggest that the cytotoxic effect of irinotecan is attributed to the interaction between the replicase and the topoisomerase I-DNA-irinotecan (or SN-38) triple complex during DNA synthesis, which causes DNA double-strand breaks. Mammalian cells cannot effectively repair these DNA double-strand breaks. Irinotecan's peers include hydroxycamptothecin, topotecan, etoposide, and teniposide. Dosage forms include oral immediate-release and injectable formulations. Currently, the main marketed dosage forms of irinotecan hydrochloride in China include lyophilized powder, regular injection, and liposome injection. The preparation of irinotecan hydrochloride injection requires a glass reactor.

[0003] In the prior art, for example, the Chinese authorization publication number CN118807648A states, "A High-Efficiency Mixing Glass-Lined Reactor," which includes a jacket, a reactor body disposed within the jacket, and a top cover disposed above the top of the reactor body. A motor frame is welded to the center of the top of the top cover, and a reduction motor is disposed within the motor frame. A transmission shaft is fixed to the output end of the reduction motor, and the bottom end of the transmission shaft extends into the reactor body. A propeller blade is welded to the transmission shaft, and a circular plate is welded to the bottom end of the transmission shaft, and the circular plate is located below the bottom of the propeller blade. A plurality of stirring plates are equidistantly welded to the periphery of the circular plate. The present invention effectively solves the problem that the prior art utilizes stirring plates to mix materials, which has limited mixing effect and low mixing efficiency, affects the mixing speed of the materials, and is not conducive to increasing the output of the mixed materials.

[0004] In the above-mentioned patent, although a stirring blade is used to mix the materials, thereby improving the mixing efficiency, it is inconvenient to flexibly control the feeding and stirring of the glass reactor. The glass reactor is inconvenient to disassemble and assemble, which affects the cleaning of the interior. It is inconvenient to heat during the stirring process, and the scope of application is limited. Therefore, there is an urgent need for a glass reactor for the preparation of irinotecan hydrochloride injection. Summary of the Invention

[0005] The object of the present invention is to provide a glass reactor for preparing irinotecan hydrochloride injection, so as to solve the problems raised in the above-mentioned background art, namely, the inconvenience in flexibly controlling the feeding and stirring of the glass reactor, the inconvenience in disassembling the glass reactor, which affects the cleaning of the interior, the inconvenience in heating during the stirring process, and the limited application range.

[0006] To achieve the above object, the present invention provides the following technical solution: a glass reactor for preparing irinotecan hydrochloride injection, comprising a supporting base plate, a glass reactor assembly disposed above the supporting base plate, and a heating collar disposed on the outside of the glass reactor assembly; An adjustment mechanism, the adjustment mechanism being located on one side of the glass reactor assembly, the adjustment mechanism comprising a rotating support rod, a first support plate being provided on one side of the top end of the rotating support rod, a second support plate being provided on the other side of the top end of the rotating support rod, and a material guide assembly being provided on one side of the second support plate; A stirring mechanism is located above the glass reactor assembly. The stirring mechanism includes a lifting bracket. A lifting card frame is provided on one side of the lifting bracket, and the lifting card frame is provided on the top of the first support plate. An electric motor is provided on one side of the lifting bracket, and a transmission gear is provided on the other side of the lifting card frame. Limiting racks meshing with the transmission gear are symmetrically provided on both sides of the opening of the lifting card frame.

[0007] As a preferred technical solution of the present invention, the glass reactor assembly includes a glass reactor body, a feed port is provided on the top of the glass reactor body, a support base is provided on the bottom of the glass reactor body, and the support base is provided on the top of the support bottom plate.

[0008] As a preferred technical solution of the present invention, the material guide assembly includes a limiting card hole, a material guide tube adapted thereto is provided inside the limiting card hole, a connected material guide funnel is provided at the top of the material guide tube, and a fixed card plate is provided at the bottom of the material guide funnel.

[0009] As a preferred technical solution of the present invention, a first gear is provided on the outer periphery of the bottom of the rotating support rod, one side of the first gear is meshed and connected with a second gear, a motor bracket is provided on the top of one side of the supporting base plate, a servo motor is provided at the bottom of the motor bracket, and the driving end of the servo motor is connected and fixed to the second gear.

[0010] As a preferred technical solution of the present invention, a closed cover is provided on one side of the first support plate, and a connecting slot adapted to the lifting bracket is provided on the open top of the closed cover.

[0011] As a preferred technical solution of the present invention, an AC motor is provided on the top of the lifting bracket, an agitator is provided on the bottom of the lifting bracket, and a driving end of the AC motor is fixedly connected to the top of the agitator.

[0012] As a preferred technical solution of the present invention, a fixed vertical plate is provided on the top of the other side of the supporting base plate, a fixed bracket is provided on one side of the top of the fixed vertical plate, and a disassembly opening is provided on one side of the heating ring.

[0013] As a preferred technical solution of the present invention, a fixing clamp ring adapted to the fixing bracket is provided on the top periphery of the glass reactor body, and auxiliary handles are symmetrically provided on both sides of the fixing clamp ring.

[0014] As a preferred technical solution of the present invention, a communicating discharge pipe is provided on one side of the bottom of the glass reactor body, and a stop valve is provided on the discharge pipe.

[0015] As a preferred technical solution of the present invention, the rotating support rod is rotatably connected to one side of the supporting base plate, and a rotating support plate rotatably connected to the top of the supporting base plate is provided at the bottom of the rotating support rod.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The glass reactor for preparing irinotecan hydrochloride injection is characterized by rotating the first and second support plates to facilitate flexible control of feeding and stirring of the glass reactor body. When the second support plate is moved above the feed port, the guide tube is inserted into the limit clamp hole, and the fixed clamp plate is connected to the top of the second support plate to improve the support stability. The raw materials for preparing irinotecan hydrochloride injection are sequentially introduced into the glass reactor body through the guide funnel. 2. The glass reactor for preparing irinotecan hydrochloride injection has an electric motor driving a transmission gear, which is connected to a limit rack to facilitate the control of the lifting and lowering of the lifting bracket. When the first support plate moves above the feed inlet, the lifting bracket drives the agitator to descend. The closing cover plate is connected to the circular convex plate on the descending lifting bracket through a connecting slot, which facilitates the sealing of the feed inlet and facilitates auxiliary stirring. After the agitator rises and resets, the first support plate can be moved; 3. The glass reactor for preparing irinotecan hydrochloride injection has a heating collar that facilitates temperature increase of the irinotecan hydrochloride injection during stirring, facilitating auxiliary stirring. During the stirring process, water for injection needs to be added and controlled at a certain temperature. Raw materials and auxiliary materials are added for stirring and dissolution. After stirring, heating needs to be stopped for cooling. The liquid medicine cools down, and attention is paid to the changes in the intermediate liquid medicine before subsequent processing. The heated mixed liquid is discharged through the discharge pipe for subsequent processing. The stop valve controls the opening and closing of the discharge, and the disassembly opening facilitates the release of the limit on the stop valve. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 2 This is a side structural schematic diagram of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 3 This is a schematic diagram of the bottom structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 4 This is a partial structural schematic diagram of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 5 This is a schematic structural diagram of an adjustment mechanism and a stirring mechanism of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 6 This is a schematic diagram of the supporting bottom plate structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 7 This is a schematic structural diagram of a glass reactor assembly for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 8 This is a schematic diagram of the heating collar structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 9 This is a schematic diagram of the lifting support structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention; Figure 10 The figure is a schematic diagram of the partial explosion structure of a glass reactor for preparing irinotecan hydrochloride injection in one embodiment of the present invention.

[0018] In the picture: 1. Support base plate; 2. Fixing vertical plate; 3. Fixing bracket; 4. Heating collar; 5. Disassembly opening; 6. Glass reactor assembly; 601. Glass reactor body; 602. Feed port; 603. Support base; 604. Fixing clamp; 605. Auxiliary handle; 606. Discharge pipe; 607. Stop valve; 7. Adjustment mechanism; 701. Rotating support rod; 702. First support plate; 703. Second support plate; 704. First gear; 705. Second gear; 706. Motor bracket; 707. Servo motor; 708. Rotating support plate; 8. Material guide assembly; 801. Position limiting hole; 802. Material guide tube; 803. Material guide funnel; 804. Fixed card; 9. Stirring mechanism; 901. Closing cover; 902. Connecting slot; 903. Lifting bracket; 904. AC motor; 905. Stirrer; 906. Lifting bracket; 907. Electric motor; 908. Transmission gear; 909. Limiting rack. DETAILED DESCRIPTION

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0020] See also Figures 1-10 The present invention provides a technical solution: a glass reactor for preparing irinotecan hydrochloride injection, comprising a fixed vertical plate 2 provided on the top of the other side of a supporting bottom plate 1, a fixed bracket 3 provided on one side of the top of the fixed vertical plate 2, a glass reactor assembly 6 provided above the supporting bottom plate 1, the fixed vertical plate 2 fixed the fixed bracket 3, the fixed bracket 3 is convenient for fixing a heating ring 4, a heating ring 4 is provided on the outside of the glass reactor assembly 6, the heating ring 4 is convenient for raising the temperature of the irinotecan hydrochloride injection during the stirring process, and is convenient for assisting stirring. In the stirring process, injection needs to be added. The injection water is controlled at a certain temperature, and the raw and auxiliary materials are added for stirring and dissolution. After stirring, the heating needs to be stopped to cool down, the liquid medicine is cooled, and attention is paid to the changes in the intermediate liquid medicine, and then subsequent processing is carried out. A fixed clamp ring 604 adapted to the fixed bracket 3 is provided on the top periphery of the glass reactor body 601, and auxiliary handles 605 are symmetrically provided on both sides of the fixed clamp ring 604. The fixed clamp ring 604 is placed on the fixed bracket 3 to facilitate the limiting of the glass reactor body 601, and the auxiliary handle 605 facilitates the lifting of the glass reactor body 601 for subsequent cleaning.

[0021] The glass reactor assembly 6 includes a glass reactor body 601, and a feed port 602 is provided on the top of the glass reactor body 601. The raw materials for preparing irinotecan hydrochloride injection enter the glass reactor body 601 through the feed port 602. A support base 603 is provided at the bottom of the glass reactor body 601, and the support base 603 is provided on the top of the supporting base plate 1. The support base 603 is convenient for improving the stability of the limit. A connected discharge pipe 606 is provided on one side of the bottom of the glass reactor body 601, and a stop valve 607 is provided on the discharge pipe 606. A disassembly opening 5 is provided on one side of the heating collar 4. The heated mixed liquid is discharged through the discharge pipe 606 for subsequent processing. The stop valve 607 controls the opening and closing of the discharge, and the disassembly opening 5 facilitates the release of the limit on the stop valve 607.

[0022] The adjustment mechanism 7 is located on one side of the glass reactor assembly 6. The adjustment mechanism 7 includes a rotating support rod 701. A first support plate 702 is provided on one side of the top of the rotating support rod 701. A second support plate 703 is provided on the other side of the top of the rotating support rod 701. Rotating the first support plate 702 and the second support plate 703 facilitates flexible control of the feeding and stirring of the glass reactor body 601. A first gear 704 is provided on the outer periphery of the bottom of the rotating support rod 701. A second gear 705 is engaged with one side of the first gear 704. A motor bracket 706 is provided on the top of one side of the supporting bottom plate 1. A servo motor 707 is provided at the bottom of 706, and the driving end of the servo motor 707 is connected and fixed to the second gear 705. The rotating support rod 701 is rotatably connected to one side of the supporting base plate 1. The bottom of the rotating support rod 701 is provided with a rotating support plate 708 rotatably connected to the top of the supporting base plate 1. The motor bracket 706 fixes the servo motor 707, and the servo motor 707 drives the second gear 705 to rotate. The second gear 705 is engaged with the first gear 704 to facilitate the driving of the rotating support rod 701 for rotation adjustment. The servo motor 707 can control the accuracy of the rotation position by setting parameters.

[0023] A material guide assembly 8 is provided on one side of the second support plate 703. The material guide assembly 8 includes a limiting card hole 801. A material guide tube 802 adapted to the limiting card hole 801 is provided inside the limiting card hole 801. A connecting material guide funnel 803 is provided at the top of the material guide tube 802. A fixed card plate 804 is provided at the bottom of the material guide funnel 803. When the second support plate 703 is moved above the feed inlet 602, the material guide tube 802 is inserted into the limiting card hole 801. The fixed card plate 804 is connected to the top of the second support plate 703 to facilitate improving the support stability. The raw materials for the preparation of irinotecan hydrochloride injection are sequentially introduced into the interior of the glass reactor body 601 through the material guide funnel 803.

[0024] A closed cover 901 is provided on one side of the first support plate 702, and a connecting slot 902 is provided on the open top of the closed cover 901 that is compatible with the lifting bracket 903. The closed cover 901 is connected to the circular convex plate on the descending lifting bracket 903 through the connecting slot 902, which is convenient for closing the feed port 602 and facilitating auxiliary stirring. The stirring mechanism 9 includes a lifting bracket 903, an AC motor 904 is provided on the top of the lifting bracket 903, and an agitator 905 is provided at the bottom of the lifting bracket 903. The driving end of the AC motor 904 is connected and fixed to the top of the agitator 905. The diameter of the agitator 905 is compatible with the feed port 602, which is convenient for penetrating into the interior of the glass reactor body 601. The AC motor 904 drives the agitator 905 to rotate to facilitate mixing and stirring the raw materials for preparing irinotecan hydrochloride injection. 03 is provided with a lifting bracket 906 on one side, and the lifting bracket 906 is provided on the top of the first support plate 702, an electric motor 907 is provided on one side of the lifting bracket 903, and a transmission gear 908 is provided on the other side of the lifting bracket 906, and limiting racks 909 that are meshed with the transmission gear 908 are symmetrically provided on both sides of the opening of the lifting bracket 906. The lifting bracket 903 is slidably connected to one side of the lifting bracket 906, and a lifting slide hole is provided on the lifting bracket 906. The transmission gear 908 is driven to rotate by the electric motor 907, and the transmission gear 908 is connected to the limiting rack 909, which is convenient for controlling the lifting and lowering of the lifting bracket 903. When the first support plate 702 moves to above the feed port 602, the lifting bracket 906 drives the agitator 905 to descend. After the agitator 905 rises and resets, the first support plate 702 can be moved.

[0025] Working principle: The servo motor 707 drives the second gear 705 to rotate. The second gear 705 engages with the first gear 704 to facilitate the rotation adjustment of the rotating support rod 701. The servo motor 707 can control the accuracy of the rotation position by setting parameters. Rotating the first support plate 702 and the second support plate 703 facilitates flexible control of the feeding and stirring of the glass reactor body 601. When the second support plate 703 moves to the top of the feed port 602, the guide tube 802 is inserted into the limit card hole 801, and the fixed card plate 804 is connected to the top of the second support plate 703 to facilitate improving the stability of the support. The raw materials for the preparation of irinotecan hydrochloride injection are sequentially introduced into the interior of the glass reactor body 601 through the guide funnel 803.

[0026] The diameter of the agitator 905 is adapted to the feed port 602, so that it can penetrate into the interior of the glass reactor body 601. The AC motor 904 drives the agitator 905 to rotate to facilitate mixing and stirring the raw materials for preparing irinotecan hydrochloride injection. The electric motor 907 drives the transmission gear 908 to rotate. The transmission gear 908 is connected to the limit rack 909 to facilitate controlling the lifting and lowering of the lifting bracket 903. When the first support plate 702 moves above the feed port 602, the lifting bracket 906 drives the agitator 905 to descend, and the closing cover plate 901 is connected to the circular convex plate on the descending lifting bracket 903 through the connecting slot 902, so as to facilitate closing the feed port 602 and assisting stirring. After the agitator 905 rises and resets, the first support plate 702 can be moved.

[0027] The fixed upright plate 2 fixes the fixed bracket 3, which is convenient for fixing the heating collar 4. The heating collar 4 is convenient for raising the temperature of the irinotecan hydrochloride injection during the stirring process to facilitate auxiliary stirring. During the stirring process, injection water needs to be added and controlled at a certain temperature. Raw materials and auxiliary materials are added for stirring and dissolution. After stirring, heating needs to be stopped to cool the liquid. The liquid medicine cools down and the changes of the intermediate liquid medicine are paid attention to before subsequent processing. The fixed collar 604 is placed on the fixed bracket 3 to facilitate limiting the glass reactor body 601. The auxiliary handle 605 facilitates lifting the glass reactor body 601 for subsequent cleaning. The raw materials for preparing the irinotecan hydrochloride injection enter the glass reactor body 601 through the feed port 602. The support base 603 facilitates improving the stability of the limit. The heated mixed liquid is discharged through the discharge pipe 606 for subsequent processing. The stop valve 607 controls the opening and closing of the discharge. The disassembly opening 5 facilitates releasing the limit of the stop valve 607.

[0028] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A glass reactor for preparing irinotecan hydrochloride injection, characterized in that: include: A supporting base plate (1), a glass reactor assembly (6) is provided above the supporting base plate (1), and a heating collar (4) is provided outside the glass reactor assembly (6); An adjusting mechanism (7), the adjusting mechanism (7) being located on one side of the glass reactor assembly (6), the adjusting mechanism (7) comprising a rotating support rod (701), a first support plate (702) being provided on one side of the top end of the rotating support rod (701), a second support plate (703) being provided on the other side of the top end of the rotating support rod (701), and a material guide assembly (8) being provided on one side of the second support plate (703); A stirring mechanism (9), the stirring mechanism (9) is located above the glass reactor assembly (6), the stirring mechanism (9) includes a lifting bracket (903), a lifting bracket (906) is provided on one side of the lifting bracket (903), and the lifting bracket (906) is provided on the top of the first support plate (702), an electric motor (907) is provided on one side of the lifting bracket (903), a transmission gear (908) is provided on the other side of the lifting bracket (906), and limiting racks (909) meshing with the transmission gear (908) are symmetrically provided on both sides of the opening of the lifting bracket (906).

2. A glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: The glass reactor assembly (6) comprises a glass reactor body (601), a feed port (602) is provided at the top of the glass reactor body (601), a support base (603) is provided at the bottom of the glass reactor body (601), and the support base (603) is arranged on the top of the support base plate (1).

3. The glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: The material guide assembly (8) comprises a limiting clamping hole (801), a material guide tube (802) adapted thereto is provided inside the limiting clamping hole (801), a connected material guide funnel (803) is provided at the top end of the material guide tube (802), and a fixed clamping plate (804) is provided at the bottom of the material guide funnel (803).

4. The glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: A first gear (704) is provided on the outer periphery of the bottom of the rotating support rod (701), and a second gear (705) is meshedly connected to one side of the first gear (704). A motor bracket (706) is provided on the top of one side of the supporting base plate (1), and a servo motor (707) is provided at the bottom of the motor bracket (706). The driving end of the servo motor (707) is connected and fixed to the second gear (705).

5. The glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: A closed cover plate (901) is provided on one side of the first support plate (702), and a connecting slot (902) adapted to the lifting bracket (903) is provided at the open top of the closed cover plate (901).

6. A glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: An AC motor (904) is provided at the top of the lifting bracket (903), a stirrer (905) is provided at the bottom of the lifting bracket (903), and a driving end of the AC motor (904) is fixedly connected to the top of the stirrer (905).

7. The glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: A fixed vertical plate (2) is provided on the top of the other side of the supporting bottom plate (1), a fixed bracket (3) is provided on one side of the top of the fixed vertical plate (2), and a disassembly opening (5) is provided on one side of the heating sleeve (4).

8. The glass reactor for preparing irinotecan hydrochloride injection according to claim 2, characterized in that: A fixing clamp ring (604) adapted to the fixing clamp frame (3) is provided on the top periphery of the glass reactor body (601), and auxiliary handles (605) are symmetrically provided on both sides of the fixing clamp ring (604).

9. A glass reactor for preparing irinotecan hydrochloride injection according to claim 2, characterized in that: A communicating discharge pipe (606) is provided on one side of the bottom of the glass reactor body (601), and a stop valve (607) is provided on the discharge pipe (606).

10. The glass reactor for preparing irinotecan hydrochloride injection according to claim 1, characterized in that: The rotating support rod (701) is rotatably connected to one side of the supporting base plate (1), and a rotating support plate (708) rotatably connected to the top of the supporting base plate (1) is provided at the bottom of the rotating support rod (701).

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