Micro-fluidic chip with quantitative and controllable Harnes jump and working method of micro-fluidic chip

Abstract

The invention belongs to the technical field of microfluidics, and discloses a Harnes jump quantitative controllable micro-fluidic chip and a working method thereof. According to the micro-fluidic chip with the quantitative and controllable Harnes jump, a micro-fluidic chip body is internally provided with a flow channel, and the flow channel is provided with a necking structure; one end of the control pipeline is used for introducing a liquid medium, and the other end of the control pipeline is used for packaging a gas medium under the combined action of the liquid medium and atmospheric pressure; the micro-fluidic chip body is also provided with a pipeline mounting channel for mounting a control pipeline; wherein the magnitude of the jump distance of the Haines jump generated at the necking structure and the dwell time of the working fluid before the Haines jump occur are controlled by adjusting the volume of the encapsulated gas medium. According to the technical scheme of the invention, the simulation control of the Harnes jump process of the fluid can be realized, the simulation authenticity of the fluid flow process can be improved, and the simulation analysis of the fluid flow process can be better assisted.

Description

Technical Field

[0001] The present invention belongs to the field of microfluidics technology, and in particular relates to a microfluidics chip with controllable Haynes jump quantity and a working method thereof. Background Art

[0002] Microfluidics is a technology that conducts analysis based on fluid flow in the fields of biology, chemistry, medicine, geology, etc. This technology integrates basic operating units such as sample preparation, reaction, separation, and detection onto a micron-scale chip, and can automatically complete the entire analysis process. Among them, microfluidic chip technology is widely used. It uses chips as an operating platform, analytical chemistry as a basis, micro-electromechanical micro-nanoscale processing technology as a support, micro-pipeline networks as structural features, and many disciplines in life sciences as its main application objects. It is the current focus of development in the field of micro-total analysis systems.

[0003] Currently, most technologies that require microfluidic chips to simulate basic flow processes to explore corresponding mechanisms, such as underground carbon dioxide storage, energy extraction, and human blood flow research, all experience the Haynes jump phenomenon during actual production or microfluidic research. However, the design of existing microfluidic chips generally does not consider the impact of the Haynes jump on the flow process, resulting in poor realism in the simulated fluid flow process. Specifically, some existing microfluidic chip designs use relatively hard materials, which increases the stiffness of the system and makes it difficult to simulate the occurrence of the Haynes jump. In addition, other microfluidic chips use relatively soft materials, and their designs have not been carefully calculated, making it difficult to unify the system stiffness and the occurrence of the Haynes jump difficult to control.

[0004] In summary, designing a new microfluidic chip with quantitatively controllable Haynes jump to better simulate a more realistic fluid flow process has become a technical problem that needs to be solved urgently. Summary of the Invention

[0005] The present invention aims to provide a microfluidic chip with quantitatively controllable Haynes jumps and its operating method to address one or more of the aforementioned technical problems. The disclosed technical solution can simulate and control the Haynes jump process of a fluid, improving the realism of fluid flow simulation and better assisting in the simulation and analysis of fluid flow processes.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions: In a first aspect, the present invention provides a microfluidic chip with a controlled Haynes jump quantity, comprising: a microfluidic chip body, a first syringe, a control pipe, a second syringe, and a pipe installation channel; wherein, The microfluidic chip body is provided with a flow channel, and the flow channel is provided with a neck structure; the inlet of the flow channel is connected to the injection port of the first syringe through an inlet pipe for introducing the working fluid; the outlet of the flow channel is connected to the atmosphere through an outlet pipe; One end of the control pipe is connected to the injection port of the second syringe for introducing the liquid medium; the other end of the control pipe is used to encapsulate a certain volume of gaseous medium under the combined action of the liquid medium and atmospheric pressure; The microfluidic chip body is further provided with a pipe installation channel for installing the control pipe; wherein one end of the pipe installation channel is connected to the flow channel and is arranged between the inlet of the flow channel and the necking structure; the other end of the pipe installation channel is used to pass through the end of the control pipe encapsulated with the gas medium; The jump distance of the Haynes jump generated at the necking structure and the pause time of the working fluid before the Haynes jump occur are controlled by adjusting the volume of the encapsulated gas medium.

[0007] A further improvement of the technical solution of the present invention is that the microfluidic chip body is made of a material with an elastic modulus greater than 10 MPa.

[0008] A further improvement of the technical solution of the present invention is that the material of the microfluidic chip body is quartz glass, silicon, polydimethylsiloxane, polymethyl methacrylate or cycloolefin polymer.

[0009] A further improvement of the technical solution of the present invention is that the microfluidic chip body adopts an upper and lower splicing structure, including an upper body and a lower body, and one or both of the upper body and the lower body are transparent.

[0010] A further improvement of the technical solution of the present invention is that the liquid medium is an incompressible fluid that is not easy to evaporate; the gas medium is a compressible ideal gas; and the working fluid is an incompressible fluid.

[0011] A further improvement of the technical solution of the present invention is that the liquid medium is hydraulic oil or water; the gaseous medium is air or nitrogen; and the working fluid is water, ethanol or glycerol.

[0012] A further improvement of the technical solution of the present invention is that both the first syringe and the second syringe are provided with a microinjection pump for controlling the injection volume.

[0013] A further improvement of the technical solution of the present invention is that it also includes: A microscope camera is used to obtain the jump distance of the Haynes jump generated at the necking structure.

[0014] A further improvement of the technical solution of the present invention is that, in the step of controlling the distance of the Haynes jump generated at the necking structure and the pause time of the working fluid before the Haynes jump occurs by adjusting the volume of the encapsulated gas medium, the relationship between the volume of the encapsulated gas medium and the distance of the Haynes jump is expressed as: V 0= LhDP 2 / ( P 1- P 2); Where, V 0 is the volume of the encapsulated gas medium; L the jump distance for Haines; h is the height of the microfluidic chip body; D is the maximum diameter of the flow channel; P 1 is the capillary pressure at the control channel interface, P 2 is the capillary pressure at the necking structure; P 1= P 0+ c cos( i )(2 / d +2 / h ); P 2= P 0+ c cos( i )(2 / D +2 / h ); Where, P 0 is the atmospheric pressure; i、c are the contact angle and surface tension of the working fluid, respectively; d It is the minimum diameter of the necking structure.

[0015] A second aspect of the present invention provides a method for operating a microfluidic chip with quantitatively controllable Haynes jumps, comprising: The working fluid in the first syringe is introduced into the flow channel in the microfluidic chip body through the inlet pipe, the outlet of the flow channel is connected to the atmosphere, and the working fluid flows in the flow channel; The liquid medium in the second syringe is introduced into the control pipe through one end of the control pipe, and under the combined action of the liquid medium and atmospheric pressure, a certain volume of gas medium is encapsulated at the other end of the control pipe; One end of the control pipe encapsulated with the gas medium is installed in the pipe installation channel provided in the microfluidic chip body and is connected to the flow channel; The volume of the gas medium encapsulated in the control pipe is adjusted to quantitatively control the Haynes jump generated at the necking structure; wherein the quantitative control includes controlling the jump distance of the Haynes jump or controlling the pause time of the working fluid before the Haynes jump occurs.

[0016] Compared with the prior art, the present invention has the following beneficial effects: Exploring the fluid flow behavior at the pore scale in porous media is a key issue in the fields of geology, biology, medicine, thermodynamics, etc. To study this process, the existing technology usually uses microfluidics methods to visualize the flow behavior at the pore scale. However, in the existing microfluidic chip technology solutions, microfluidic chips made of hard materials may cause the loss of the Haynes jump phenomenon, and microfluidic chips made of soft materials may cause uncontrollable Haynes jump phenomena. Both of the above phenomena will cause the infiltration behavior at the pore scale to deviate significantly from expectations, which will bring difficulties to subsequent analysis. In view of the above existing technical problems, the present invention specifically discloses a new microfluidic chip with quantitative controllable Haynes jump, which introduces an encapsulated gas medium as a technical means to adjust the stiffness of the microfluidic chip body, thereby achieving accurate, fast and low-cost quantitative control of the Haynes jump, and can simulate the Haynes jump behavior in different application scenarios, greatly enhancing the accuracy of the pore-scale fluid flow behavior and making the research results more realistic and reliable. In summary, the technical solution of the present invention improves the controllability of microfluidic chip simulation experiments and improves the authenticity and reliability of the experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below; obviously, the drawings described below are some embodiments of the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 This is a schematic structural diagram of a microfluidic chip with quantitatively controllable Haynes jumps in an embodiment of the present invention; The explanation of the reference numerals in the figures is as follows: 1. Microfluidic chip body; 2. Flow channel; 3. Inlet pipe; 4. Outlet pipe; 5. First syringe; 6. Working fluid; 7. Neck structure; 8. Pipe installation channel; 9. Control pipe; 10. Second syringe; 11. Gas medium; 12. Liquid medium. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention; it is obvious that the described embodiments and technical solutions are only part of the embodiments of the present invention, not all of the embodiments.

[0020] All other embodiments obtained by persons of ordinary skill in the art based on the technical solutions disclosed in the embodiments of the present invention without creative effort shall fall within the scope of protection of the present invention. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units that are not explicitly listed or that are inherent to these processes, methods, products, or apparatuses.

[0021] See also Figure 1 The embodiment of the present invention provides a microfluidic chip with controllable Haynes jump quantity, comprising: a microfluidic chip body 1, a first syringe 5, a control pipe 9, a second syringe 10 and a pipe installation channel 8; wherein, The microfluidic chip body 1 is provided with a flow channel 2 for introducing a working fluid 6. The flow channel 2 is provided with a necking structure 7. The inlet of the flow channel 2 is connected to the injection port of the first syringe 5 through an inlet pipe 3, and the outlet of the flow channel 2 is connected to the atmosphere through an outlet pipe 4. One end of the control pipe 9 is connected to the injection port of the second syringe 10 for introducing a liquid medium 12; the other end of the control pipe 9 is used to encapsulate a certain volume of gas medium 11 under the combined action of the liquid medium 12 and atmospheric pressure; The microfluidic chip body 1 is provided with a pipe installation channel 8 for installing the control pipe 9; wherein, one end of the pipe installation channel 8 is connected to the flow channel 2 and is arranged between the inlet of the flow channel 2 and the necking structure 7; the other end of the pipe installation channel 8 is used to pass through the end of the control pipe 9 encapsulated with the gas medium 11; Explanatoryally, under the influence of the encapsulated gas medium 11, the stiffness of the microfluidic chip body 1 is adjustable, and a quantitatively controllable Haynes jump can be generated at the necking structure 7 of the flow channel 2; wherein, the jump distance of the Haynes jump generated at the necking structure 7 and the pause time of the liquid working fluid 6 before the Haynes jump occurs are controlled by adjusting the volume of the encapsulated gas medium 11.

[0022] The technical solution disclosed in the embodiment of the present invention can control the distance and size of the Haynes jump generated in the microfluidic chip body, which can not only well simulate and analyze the impact of the size of the Haynes jump on the fluid flow, but also eliminate or reduce the impact of the Haynes jump on the fluid flow test when necessary through this control method, thereby improving the controllability of the microfluidic chip simulation test and improving the reliability of the test.

[0023] In a specific exemplary technical solution of an embodiment of the present invention, the microfluidic chip body 1 is made of a material with an elastic modulus greater than 10 MPa, such as quartz glass, silicon, polydimethylsiloxane, polymethyl methacrylate, cycloolefin polymer, etc.; in a further exemplary technical solution, the microfluidic chip body 1 adopts an upper and lower splicing structure, including an upper body and a lower body, and one or both of the upper body and the lower body are transparent.

[0024] In a specific exemplary embodiment of the present invention, the liquid medium 12 can be an incompressible fluid that is not easily evaporated, such as hydraulic oil or water; the gaseous medium 11 can be a compressible ideal gas, such as air or nitrogen; and the working fluid 6 can be an incompressible fluid, such as water, ethanol, or glycerol. In this specific exemplary embodiment, the control liquid medium 12 is hydraulic oil, which is less miscible with the pressurized gas, enabling better control. Furthermore, hydraulic oil has low compressibility and does not introduce additional elastic deformation.

[0025] In a specific exemplary technical solution of the present invention, both the first syringe 5 and the second syringe 10 are provided with a microinjection pump for controlling the injection volume.

[0026] In the preferred technical solution disclosed in the embodiment of the present invention, the overall system stiffness of the microfluidic chip body is limited by limiting the material of the microfluidic chip body; at the same time, a gas volume control system is introduced to accurately adjust the volume of the encapsulated gas medium. The encapsulated gas medium is a compressible gas. By adjusting the volume of the pressurized gas medium, the stiffness of the microfluidic chip body can be flexibly adjusted. The gas volume control system and the rigid microfluidic chip constitute a microfluidic experimental system with adjustable system stiffness. In a one-dimensional system, the distance of the Haynes jump and the corresponding waiting time are only determined by the system stiffness. The distance of the Haynes jump and the pause time before the Haynes jump are linearly proportional to the deformation variable of the encapsulated gas system; therefore, by adjusting the system stiffness, the deformation variable of the overall system can be controlled, thereby achieving control of the distance of the Haynes jump and the pause time before the Haynes jump.

[0027] The principle explanation of the technical solution disclosed in the embodiment of the present invention is that the micro-injection pump controls the flow of the working fluid in the first syringe, and after passing through the control channel position, the gas at the front end of the control channel is sealed to form a section of sealed gas. When the working fluid continues to pass through the necking structure, it is compressed and squeezed. In this way, a mutual squeezing force is formed between the working fluid and the gas medium encapsulated at the front end of the control channel. This force will cause the deformation of the encapsulated gas medium. Under the same force, the larger the original volume of the encapsulated gas medium, the greater the deformation generated, and the smaller the original volume of the encapsulated gas medium, the smaller the deformation generated. The degree of this deformation will affect the distance of the Haynes jump. Based on the above theory, the position of the front end of the control liquid medium can be adjusted in advance by the second syringe controlled by the micro-injection pump to adjust the volume of the encapsulated gas medium, thereby controlling the rebound force of the sealed gas medium when the Haynes jump occurs, and thus controlling the distance of the Haynes jump.

[0028] In summary, the technical solution of the embodiment of the present invention utilizes the incompatibility of the gas and liquid interface to control the distance of the Haynes jump by adjusting the volume of the sealed gas medium at the control channel connection, thereby better achieving the regulation and control of micro-pressure. Moreover, this force is passively applied, which has better reliability and controllability than the active pressure regulation method. At the same time, because the Haynes jump occurs in an extremely short time, the passive regulation method can achieve a more precise regulation effect. In addition, the relationship between the volume of the sealed gas medium at the control channel connection and the distance of the Haynes jump can be obtained by calculation or experimentally determined using a test device.

[0029] In an embodiment of the present invention, the relationship between the volume of the sealed gas medium at the connection of the control channel and the jump distance of the Haynes jump is obtained by calculation, including the following steps: Determination of the Haynes jump distance, including: determining the required Haynes jump distance based on the specific application and experimental distance requirements L , input the results into the computer; Determination of the geometric parameters of the neck structure, including: determining the minimum diameter of the neck structure based on the pore geometric parameters of the neck structure designed by the microfluidic chip d , microfluidic chip body height h , and the maximum diameter of the flow channel D , input the results into the computer; Determine the physical properties of the working fluid, including: determining the contact angle of the working fluid according to the physical properties of the working fluid i and surface tension c , input the results into the computer; Determine atmospheric pressure P0, enter the result into the computer; Calculate the capillary pressure at the control channel interface P 1 and capillary pressure at the neck P 2. According to the Young-Laplace equation (Young's equation), P 1= P 0+ c cos( i )(2 / d +2 / h ); P 2= P 0+ c cos( i )(2 / D +2 / h ); Calculation implementation jump L Desired bubble size V 0: LhD P 2 / ( P 1- P 2); Adjust the syringe piston position of the second microinjection pump to keep the remaining air volume at the control channel interface at V 0 is enough.

[0030] In an embodiment of the present invention, the relationship between the volume of the sealed gas medium at the connection of the control channel and the distance of the Haynes jump is obtained through experiments, including the following steps: The relationship between the volume of the sealed gas at the control channel connection and the distance of the Haynes jump at the flow channel necking is measured by a microfluidic chip Haynes jump test device; wherein, In the microfluidic chip Haynes jump test device, a test flow channel is provided in the front and rear flow channels of the necking structure of the microfluidic chip body to be tested, which simulates the necking structure of the microfluidic chip body to be tested; a test necking structure is provided in the test flow channel, which simulates the necking structure of the microfluidic chip body to be tested; an inlet is provided at one end of the test flow channel and is connected to the test inlet pipe, and an outlet is provided at the other end and is connected to the test outlet pipe, the test inlet pipe is connected to the syringe of a first micro-injection pump for testing, the syringe of the first micro-injection pump for testing is filled with working fluid, and the test microfluidic chip is connected to the test outlet pipe. A test control channel is vertically connected to the test flow channel at the position before the test necking structure. The test control channel is consistent in size with the simulated control channel and is externally connected to a test control pipe. The test control pipe is connected to the syringe of a second micro-injection pump for testing. A section of control gas is encapsulated at the junction of the front end of the test control channel and the test flow channel, and the rear end of the test control channel and the corresponding syringe of the second micro-injection pump for testing are filled with control liquid; the test microfluidic chip is made of transparent material and a microscope camera is arranged at the upper end.

[0031] In a preferred embodiment of the present invention, the front-to-back positional structure of the constriction of the test microfluidic chip and the microfluidic chip to be simulated in the microfluidic chip Haynes jump test apparatus is identical. This allows the control process of the Haynes jump to be simulated. A one-to-one correspondence between the volume of control gas at the front end of the control channel and the distance of the Haynes jump is obtained through observation and measurement with a microscope and camera. In the actual control process, the volume of the control gas can be adjusted based on this correspondence to control the distance of the Haynes jump.

[0032] To explain the term, the Haines jump refers to the physical phenomenon that occurs when a fluid flows through a pore. Liquid flow in porous media is not uniform, but rather exhibits a dynamic, unbalanced state. As the fluid interface passes through irregular pores, its shape adjusts as the pore dimensions change, causing the curvature of the interface to continuously change. This change not only affects the shape of the interface but also causes the capillary pressure on both sides of the interface to fluctuate. As a result, the meniscus expands and contracts, often with sudden, abrupt changes in shape due to the irregularities of the pores and the dynamic changes in the interface. This abrupt change indicates that the fluid is not flowing uniformly through the porous medium, but rather exhibits a jump-like flow pattern. This jump phenomenon is known as the Haines jump.

[0033] An embodiment of the present invention discloses a microfluidic chip capable of achieving quantitative control of a Haynes jump. In the microfluidic chip body, a working fluid is controlled to pass through a constriction in the flow channel under pressure, generating a quantitatively controllable Haynes jump. A control channel is connected to the microfluidic chip body before the flow channel enters the constriction. After the working fluid flows through the control channel and before reaching the constriction, a gas medium encapsulated in the control channel applies lateral pressure to the working fluid. By (pre-)adjusting the volume of the gas medium, the distance of the Haynes jump generated at the constriction is controlled. The technical solution of the embodiment of the present invention can simulate and control the Haynes jump process of a fluid, thereby improving the authenticity of fluid flow simulation and assisting in the simulation analysis of fluid flow processes.

[0034] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in the field should understand that the specific implementation methods of the present invention can still be modified or replaced by equivalents. Any modification or equivalent replacement that does not depart from the spirit and scope of the present invention should be covered by the scope of protection of the claims of the present invention.

Claims

1. A microfluidic chip with quantitatively controllable Haynes jump, characterized in that: include: A microfluidic chip body (1), a first syringe (5), a control pipeline (9), a second syringe (10) and a pipeline installation channel (8); wherein, A flow channel (2) is provided in the microfluidic chip body (1), and the flow channel (2) is provided with a necking structure (7); the inlet of the flow channel (2) is connected to the injection port of the first syringe (5) through the inlet pipe (3) for introducing the working fluid (6); the outlet of the flow channel (2) is connected to the atmosphere through the outlet pipe (4); One end of the control pipe (9) is connected to the injection port of the second syringe (10) for introducing the liquid medium (12); the other end of the control pipe (9) is used to encapsulate a certain volume of gas medium (11) under the combined action of the liquid medium (12) and atmospheric pressure; The microfluidic chip body (1) is further provided with a pipe installation channel (8) for installing the control pipe (9); wherein one end of the pipe installation channel (8) is connected to the flow channel (2) and is arranged between the inlet of the flow channel (2) and the necking structure (7); the other end of the pipe installation channel (8) is used to pass through one end of the control pipe (9) encapsulated with the gas medium (11); The jump distance of the Haynes jump generated at the necking structure (7) and the pause time of the working fluid (6) before the Haynes jump occur are controlled by adjusting the volume of the encapsulated gas medium (11).

2. A microfluidic chip with quantitatively controllable Haynes jump according to claim 1, characterized in that: The microfluidic chip body (1) is made of a material with an elastic modulus greater than 10 MPa.

3. A microfluidic chip with quantitatively controllable Haynes jump according to claim 2, characterized in that: The material of the microfluidic chip body (1) is quartz glass, silicon, polydimethylsiloxane, polymethyl methacrylate or cycloolefin polymer.

4. A microfluidic chip with quantitatively controllable Haynes jump according to claim 2, characterized in that: The microfluidic chip body (1) adopts an upper and lower splicing structure, comprising an upper body and a lower body, and one or both of the upper body and the lower body are transparent.

5. The microfluidic chip with quantitatively controllable Haynes jump according to claim 1, characterized in that: The liquid medium (12) is an incompressible fluid that is not easy to evaporate; The gas medium (11) is a compressible ideal gas; and the working fluid (6) is an incompressible fluid.

6. The microfluidic chip with quantitatively controllable Haynes jump according to claim 5, characterized in that: The liquid medium (12) is hydraulic oil or water; the gaseous medium (11) is air or nitrogen; and the working fluid (6) is water, ethanol, or glycerol.

7. The microfluidic chip with quantitatively controllable Haynes jump according to claim 1, characterized in that: The first syringe (5) and the second syringe (10) are both provided with a microinjection pump for controlling the injection volume.

8. The microfluidic chip with quantitatively controllable Haynes jump according to claim 1, characterized in that: Also includes: A microscope camera is used to obtain the jump distance of the Haynes jump generated at the necking structure (7).

9. The microfluidic chip with quantitatively controllable Haynes jump according to claim 1, characterized in that: In the step of controlling the distance of the Haynes jump generated at the necking structure (7) and the pause time of the working fluid (6) before the Haynes jump occurs by adjusting the volume of the encapsulated gas medium (11), the relationship between the volume of the encapsulated gas medium and the distance of the Haynes jump is expressed as: V 0= LqCy 2 / ( P 1- P 2)； Where, V 0 is the volume of the encapsulated gas medium; L the jump distance for Haines; h is the height of the microfluidic chip body; D is the maximum diameter of the flow channel; P 1 is the capillary pressure at the control channel interface, P 2 is the capillary pressure at the necking structure; P 1 = P 0+ γ cos( θ )(2 / d +2 / h ); P 2 = P 0+ γ cos( θ )(2 / D +2 / h ); Where, P 0 is the atmospheric pressure; θ, γ are the contact angle and surface tension of the working fluid, respectively; d It is the minimum diameter of the necking structure.

10. A method for operating the microfluidic chip with quantitatively controllable Haynes jumps according to claim 1, characterized in that: include: The working fluid (6) in the first syringe (5) is introduced into the flow channel (2) in the microfluidic chip body (1) through the inlet pipe (3), and the working fluid (6) flows in the flow channel (2); The liquid medium (12) in the second syringe (10) is introduced into the control pipe (9) through one end of the control pipe (9), and under the combined action of the liquid medium (12) and atmospheric pressure, a certain volume of gas medium (11) is encapsulated at the other end of the control pipe (9); One end of the control pipe (9) encapsulating the gas medium (11) is installed in the pipe installation channel (8) provided in the microfluidic chip body (1) and is connected to the flow channel (2); The volume of the gas medium (11) encapsulated in the control pipe (9) is adjusted to quantitatively control the Haynes jump generated at the necking structure (7); wherein the quantitative control includes controlling the jump distance of the Haynes jump or controlling the pause time of the working fluid (6) before the Haynes jump occurs.

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