Development of special medical food for diabetes mellitus compounded by marine active substances and medicine and food homology

Abstract

The invention belongs to the technical field of special medical food, and particularly relates to development of special medical food for diabetes by compounding marine active substances with homology of medicine and food. The product is prepared by compounding marine active substances (such as algal polysaccharides, alginic acid and marine collagen) and medicinal and edible components (such as cyclocarya paliurus, folium mori and radix puerariae) as a core through scientific proportioning and a special medical food compliance process. The product has a remarkable blood sugar reducing effect, provides comprehensive nutrition support and is suitable for diabetics. The core technology comprises the steps of extraction and purification of marine active substances, synergistic interaction proportioning of medicinal and edible components and standardized production process of special medical food. Clinical tests show that the product can effectively regulate the blood sugar level and improve blood fat metabolism, and has no side effect.

Description

Technical Field

[0001] The present invention relates to the technical field of special medical foods, and in particular to a diabetic food with a specific complete nutritional formula based on a combination of marine active substances and medicinal and edible ingredients, which is suitable for patients with diabetes and its complications. Background Art

[0002] Diabetes is a global health problem, and traditional glucose-lowering medications often come with side effects. Existing special medical foods are mostly single-ingredient, with limited effectiveness. Marine bioactive substances possess unique biological activities, but they have yet to be fully utilized in the diabetes field. Summary of the Invention

[0003] The present invention combines marine active substances with medicinal and edible ingredients, and provides a safe and efficient diabetic food through scientific proportioning and special medical technology. DETAILED DESCRIPTION

[0004] Example 1: - Formula: 20 parts of seaweed polysaccharide, 10 parts of alginic acid, 15 parts of Cyclocarya paliurus extract, 20 parts of oligofructose; - Preparation: After enzymatic hydrolysis of the seaweed, mix it with the other ingredients and granulate it;

[0005] Example 2 - Formula: Marine collagen 10 parts, mulberry leaf extract 12 parts, resistant dextrin 25 parts; - Preparation: Spray drying followed by tableting. clinical trials

[0006] After 30 days of taking the drug, 100 subjects saw their average fasting blood sugar drop by 2.5 mmol / L and their glycosylated hemoglobin drop by 1.2%, with no adverse reactions. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] Figure 1-2 illustrate: Figure 1 The product preparation process flow chart is as follows: Figure 2 This is a comparison chart of blood sugar changes in clinical trials. Remarks

[0008] This invention has completed nine months of continuous, comprehensive animal testing at the National Animal Laboratory of Shenzhen People's Hospital and has passed genetic testing at BGI. Following completion of clinical trials, the project plans to apply for registration with the National Special Medical Food Registration Authority. The project has already won the Gold Award at the 2024 China International University Student Innovation Competition in Shanxi Province. Its nutritionally complete diabetes food formula has been incorporated into Tianjin Baina Biotechnology Co., Ltd.'s product lines, including "Medical Food Worry-Free" and "Medical Food Delicious," and has established a solid foundation for industrialization.

Claims

1. Development and application of a specific complete nutritional formula diabetic food based on marine active substances and medicine-food compounding technology, characterized by: Includes the following components: - Marine active ingredients: 10-30 parts of seaweed polysaccharides, 5-20 parts of alginic acid, 5-15 parts of marine collagen; - Medicinal and edible ingredients: 10-25 parts of Cyclocarya paliurus extract, 8-20 parts of mulberry leaf extract, and 5-15 parts of Pueraria root extract; - Nutritional supplements: 1-5 parts multivitamins, 1-5 parts minerals, 10-30 parts dietary fiber; - Excipients: 0.1-2 parts of stabilizer, 0.1-1 parts of flavoring agent.

2. The diabetic food according to claim 1, wherein The molecular weight of the seaweed polysaccharide is 100,000-1,000,000 Da, the deacetylation degree of alginic acid is 70-90%, and the molecular weight of the peptide segment of marine collagen is 1,000-5,000 Da.

3. The diabetic food according to claim 1, wherein The extract of the medicinal and edible component is a water extract or an alcohol extract, and the active ingredient content thereof is ≥50%.

4. The diabetic food according to claim 1, wherein The dietary fiber is one or more of oligofructose, inulin or resistant dextrin.

5. The method for preparing the diabetic food according to any one of claims 1 to 4, wherein: The following steps are involved: - Extraction of marine active substances: seaweed is crushed and then purified by enzymatic hydrolysis, centrifugation and ultrafiltration; - Extraction of medicinal and edible ingredients: using water extraction or alcohol extraction, followed by concentration and spray drying; - Mixing and formulation: Mix the components in proportion, add excipients and prepare into granules, tablets or liquid dosage forms.

6. The preparation method according to claim 5, wherein The extraction of the marine active substance requires controlling the pH to be 6-8, the temperature to be 40-60° C., and the enzymatic hydrolysis time to be 2-6 hours.

7. The method for taking the diabetic food according to any one of claims 1 to 4, characterized in that: Take 5-10 grams twice a day with warm water before meals.

8. Use of the diabetic food according to any one of claims 1 to 4 in the preparation of a special medical food for lowering blood sugar or improving diabetic complications.

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