Coating device for artificial blood vessel collagen intima

Abstract

The invention provides a coating device for an artificial blood vessel collagen intima, and relates to the field of manufacturing of medical instruments, and the coating device for the artificial blood vessel collagen intima comprises an artificial blood vessel fixing part used for fixing an artificial blood vessel; the solution output assembly is used for outputting the collagen solution; the solution tube is communicated with the solution output assembly, the solution tube extends to form a free end, a solution outlet is formed in the position, close to the free end, of the solution tube, and the part, provided with the solution outlet, of the solution tube and the artificial blood vessel are coaxially arranged; the sponge delivery structure is used for installing a sponge, and the sponge can be arranged outside the liquid outlet in a sleeving mode; the solution tube driving assembly is connected with the solution tube and used for driving the part, provided with the liquid outlet, of the solution tube to move in the first direction, and the first direction is parallel to the length direction of the artificial blood vessel; the extruding device can extend into the artificial blood vessel and extrude the inner wall of the artificial blood vessel. According to the coating device, the coating efficiency is improved, and a more uniform collagen inner membrane can be formed.

Description

Technical Field

[0001] The present invention relates to the field of manufacturing medical devices, in particular to a coating device for an artificial blood vessel collagen endothelium. Background Art

[0002] During the manufacturing process of artificial blood vessels, collagen is coated on the inner wall of the artificial blood vessels to form a collagen lining to improve the anti-seepage performance of the artificial blood vessels. The existing manufacturing process uses manual coating to form this lining, which requires high labor costs, has low coating efficiency, and produces an uneven coating. Summary of the Invention

[0003] The present invention provides a device for coating collagen endothelium of an artificial blood vessel, which is used for reducing the labor cost of coating collagen endothelium, improving the coating efficiency of collagen endothelium, and making the formed collagen endothelium more uniform.

[0004] An embodiment of the present invention provides a device for coating the collagen endothelium of an artificial blood vessel, the coating device comprising: an artificial blood vessel fixing member for fixing the artificial blood vessel; a solution output assembly for outputting a collagen solution; a solution tube connected to the solution output assembly, the solution tube extending to form a free end, the solution tube being provided with a solution outlet near the free end, and the portion of the solution tube having the outlet being coaxially arranged with the artificial blood vessel; a sponge delivery structure for installing a sponge, the sponge being capable of being sleeved on the outside of the outlet; a solution tube driving assembly connected to the solution tube and configured to drive the portion of the solution tube having the outlet to move in a first direction, the first direction being parallel to the length direction of the artificial blood vessel; and an extrusion device capable of extending into the artificial blood vessel and extruding the inner wall of the artificial blood vessel.

[0005] In some embodiments, the extrusion device includes: an expansion structure capable of generating elastic deformation; a driving structure for driving the expansion structure to move in or out of the artificial blood vessel; and an air supply component connected to the expansion structure for expanding the expansion structure.

[0006] In some embodiments, the expansion structure is sleeved on the outside of the solution tube; wherein the driving structure is the solution tube driving assembly.

[0007] In some embodiments, the sponge delivery structure includes: a sponge mounting structure for mounting the sponge; a rotating motor connected to the sponge mounting structure for driving the sponge mounting structure to rotate; wherein the rotation axis of the sponge mounting structure is parallel to the first direction, and the sponge mounting structure can rotate between the free end and the artificial blood vessel.

[0008] In some embodiments, the sponge mounting structure includes: a mounting member, which surrounds a mounting cavity for mounting the sponge, and in the first direction, the opening of the mounting cavity is located on both sides of the mounting member; an elastic baffle, which is detachably installed in the mounting cavity and, in the first direction, is located on the side of the mounting cavity away from the free end; wherein, the elastic baffle is a ring-shaped member, and the elastic baffle can produce elastic deformation in the radial direction of the mounting cavity.

[0009] In some embodiments, the coating device further includes a drying device having a drying chamber therein; wherein the artificial blood vessel fixing member is located in the drying chamber, the drying device has a connecting port connected to the drying chamber, and the connecting port is located between the free end and the artificial blood vessel fixing member.

[0010] In some embodiments, the coating device further includes: an artificial blood vessel rotating structure connected to the artificial blood vessel fixing member, for driving the artificial blood vessel fixing member to rotate and drive the artificial blood vessel to rotate, and the rotation axis of the artificial blood vessel fixing member is parallel to the first direction.

[0011] In some embodiments, the coating device further includes: a sealing member; and a sealing member driving structure for driving the sealing member to move between a first position and a second position, wherein the sealing member blocks the communicating port at the first position and removes the blockage of the communicating port at the second position.

[0012] In some embodiments, the sponge delivery structure further includes: a rotating frame connected to the rotating motor, the rotation axis of the rotating frame being parallel to the first direction; wherein the sponge mounting structure and the sealing member are arranged at circumferential intervals along the rotating frame, and the sealing member can rotate to the first position.

[0013] In some embodiments, the solution output component includes: an injection syringe, which contains the collagen solution and is connected to the solution tube, and is used to output the collagen solution into the solution tube; and a drive syringe, which is connected to the solution tube, and is used to drive the collagen solution to move along the extension direction of the solution tube.

[0014] An embodiment of the present invention provides a coating device for the collagen endothelium of an artificial blood vessel, the coating device comprising an artificial blood vessel fixing part for fixing the artificial blood vessel, a solution output component for outputting collagen, a solution tube connected to the solution output component, one end of the solution tube is fixedly connected to the solution output component, and the other end extends to form a free end, the solution tube has a liquid outlet near the free end, and the solution output component can drive the collagen to flow to the liquid outlet along the extension direction of the solution tube; the coating device also comprises a sponge delivery structure and a solution tube driving component, the sponge delivery structure is used to install a sponge and the sponge can be sleeved on the outside of the liquid outlet of the solution tube, the solution tube driving component drives the part of the solution tube with the liquid outlet to move in a first direction, the first direction is the extension direction of the artificial blood vessel and The portion of the solution tube having the liquid outlet is coaxial with the artificial blood vessel. By driving the solution tube to move in a first direction, the solution tube can drive the sponge to extend into the artificial blood vessel and move along the extension direction of the artificial blood vessel. At the same time, the collagen solution flowing out of the liquid outlet is absorbed by the sponge and evenly applied to the inner wall of the artificial blood vessel. This coating device can automatically achieve the coating of the collagen endothelium, reducing labor costs, and can quickly achieve the coating of the collagen endothelium through one movement, thereby improving the coating efficiency of the collagen endothelium. Moreover, the coating device also includes an extrusion device, which can extend into the artificial blood vessel and extrude the inner wall coated with the collagen solution. The collagen endothelium formed under the action of the extrusion force can be more uniform and the combination of the collagen endothelium and the artificial blood vessel is also tighter. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A schematic structural diagram of a first artificial blood vessel collagen endothelium coating device provided in an embodiment of the invention; Figure 2 A schematic structural diagram of a solution tube in a device for coating an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 3 A schematic diagram of the assembly of a rotating motor, a sponge mounting structure, and a blocking member in a device for coating the collagen lining of an artificial blood vessel provided by an embodiment of the present invention; Figure 4 A schematic structural diagram of a sponge installation structure in a device for coating an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 5 A schematic diagram of the assembly of a drying device and an artificial blood vessel fixing member in a coating device for an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 6 A schematic diagram of the relative positional relationship between a blocking member and a communication port in a device for coating an artificial blood vessel collagen endothelium provided by an embodiment of the present invention; Figure 7A schematic diagram of the assembly of a solution driving component and a solution tube in a device for coating an artificial blood vessel collagen endothelium provided by an embodiment of the present invention; Figure 8 A schematic structural diagram of an extrusion device in a coating device for an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 9 A schematic structural diagram of an air supply structure in a device for coating an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 10 A schematic diagram of the assembly of an expansion structure, an air supply structure, and a solution tube in a device for coating an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 11 A schematic diagram of the assembly of an expansion structure and a solution tube in a device for coating an artificial blood vessel collagen lining provided by an embodiment of the present invention; Figure 12 A schematic structural diagram of a driving component in a device for coating an artificial blood vessel collagen endothelium provided by an embodiment of the present invention.

[0016] Description of Reference Numerals 10. Artificial blood vessel fixing structure; 20. Solution output assembly; 21. Liquid injection syringe; 22. Drive syringe; 30. Solution tube; 31. Liquid outlet; 40. Sponge delivery device; 41. Sponge mounting structure; 411. Mounting part; 412. Elastic baffle; 413. Mounting cavity; 42. Rotating motor; 50. Solution tube drive assembly; 60. Drying device; 61. Drying shell; 611. Drying cavity; 612. Connecting port; 62. Hot air blower; 63. Artificial blood vessel rotating structure; 71. Blocking part; 72. Blocking part drive structure; 80. Extrusion device; 81. Expansion structure; 82. Drive structure; 83. Air supply assembly; 831. Air supply syringe; 832. Air supply pipe; 833. Syringe drive part; 834. Pressure gauge; 91. Base; 92. Rotating drive motor; 93. Slider; 94. Guide rod; 95. Screw. DETAILED DESCRIPTION

[0017] In order to make the objectives, technical solutions and advantages of the present invention more clear, the present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0018] The various specific technical features in the various embodiments described in the specific implementation methods can be combined in various ways without contradiction. For example, different implementation methods can be formed by combining different specific technical features. In order to avoid unnecessary repetition, the various possible combinations of the specific technical features in the present invention will not be described separately.

[0019] It should also be noted here that, in order to avoid obscuring the present invention due to unnecessary details, only structures and / or processing steps closely related to the solutions of the present invention are shown in the drawings, while other details that are not closely related to the present invention are omitted.

[0020] In addition, it should be noted that the terms "include", "comprising" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the following description, the terms "first\second\..." involved are merely used to distinguish different objects and do not indicate that there is any similarity or connection between the objects. It should be understood that the directions described by the directional nouns such as "above", "below", "inside" and "outside" are all directions in normal use.

[0021] In the following specific embodiments, a device for coating an artificial blood vessel with collagen intima is used to coat the inner wall of an artificial blood vessel with collagen to form a collagen intima, thereby improving the artificial blood vessel's anti-seepage capabilities. The artificial blood vessel can be made of any harmless material. For example, the artificial blood vessel can be made of one or more of polyester, polytetrafluoroethylene, and polyurethane. The structure and function of the device for coating an artificial blood vessel with collagen intima will be described below, using an artificial blood vessel made of polyester as an example.

[0022] In some embodiments, as Figure 1 As shown, the device for coating the collagen endothelium of an artificial blood vessel includes: an artificial blood vessel fixing member 10, a solution output component 20, a solution tube 30, a sponge delivery device 40, and a solution tube driving member 50. The artificial blood vessel fixing member 10 is used to fix the artificial blood vessel and to flatten the wrinkles of the artificial blood vessel, thereby facilitating the subsequent coating of collagen on the inner wall of the artificial blood vessel; the solution output component 20 is used to output the collagen solution, and the solution tube 30 is connected to the solution output component 20. The collagen solution can move along the extension direction of the solution tube 30 under the drive of the solution output component 20. Specifically, one end of the solution tube 30 is connected to the solution output component 20, and the other end extends to form a free end, as shown in FIG. Figure 2As shown, the solution tube 30 is provided with a solution outlet 31 near the free end, and the collagen solution can flow from the solution output component 20 along the solution tube 30 to the solution outlet 31; wherein, the solution output component 20 accommodates the collagen solution through its own integrated accommodating cavity, and can also obtain externally stored collagen solution through the collagen input port, and the solution output component 20 can provide driving force for the collagen solution in any way. Exemplarily, the solution output component 20 includes a syringe and a syringe driver, and the syringe is driven by the syringe driver to drive the collagen solution to move. Exemplarily, the solution output component 20 includes a liquid pump, and the collagen solution is driven by the liquid pump to move; the solution output tube 30 can be made of any material. Exemplarily, the solution output tube 30 can be made of a plastic material or a metal material.

[0023] The sponge delivery structure 40 is used to install the sponge, and the solution tube driving assembly 50 is connected to the solution tube 30 and is used to drive the part of the solution tube 30 with the liquid outlet 31 to move in a first direction, which is parallel to the length direction of the artificial blood vessel. The part of the solution tube 30 with the liquid outlet 31 is coaxially arranged with the artificial blood vessel. The movement of the solution tube 30 in the first direction can make the part of the solution tube 30 with the liquid outlet 31 extend into or move out of the artificial blood vessel. At the same time, the sponge can be sleeved on the outside of the liquid outlet 31, and the collagen solution can flow out of the liquid outlet 31 and be absorbed by the sponge. The sponge can move in the artificial blood vessel with the solution tube 30 so that the absorbed collagen solution is evenly spread on the inner wall of the artificial blood vessel. The coating process does not require manual coating by personnel, and the sponge can achieve the coating of the collagen endothelium with one movement of the solution tube 30 in the artificial blood vessel, thereby improving the coating efficiency of the collagen endothelium. Optionally, the solution tube 30 can move as a whole along with the solution tube drive assembly 50, and the solution output component 20 moves along with the solution tube 30; optionally, the solution tube 30 includes a fixed part and a movable part, the fixed part is connected to the solution output assembly 20, the movable part is slidably connected to the fixed part and the movable part can move along the first direction, and the liquid outlet 31 is arranged on the movable part.

[0024] It should be noted that the sponge can be automatically installed in any way. Exemplarily, the sponge delivery structure 40 is a robot, so that the sponge can be actively installed on the outside of the solution tube 30. Exemplarily, the sponge delivery structure 40 can place the sponge in a predetermined position, and through the movement of the solution tube 30 in the first direction, the solution tube 30 can be poked into the sponge, thereby installing the sponge on the outside of the solution tube 30.

[0025] At the same time, the coating device also includes an extrusion device 80, which can extend into the interior of the artificial blood vessel and squeeze the inner wall of the artificial blood vessel coated with the collagen solution, so that the collagen solution can be more evenly distributed on the surface of the inner wall, thereby making the formation of the collagen inner membrane more uniform. This extrusion effect can also make the collagen and the inner wall of the artificial blood vessel more tightly combined. It should be noted that the extrusion device 80 is any structure that can be inserted into the artificial blood vessel and apply an extrusion force to the inner wall of the artificial blood vessel. Exemplarily, the extrusion device 80 is an elastic airbag and the elastic airbag can form a slight interference fit with the inner wall of the artificial blood vessel. In the process of inserting the elastic airbag into the artificial blood vessel, the elastic airbag generates elastic compression deformation, and after inserting into the artificial blood vessel, the elastic force generated by the elastic deformation applies an extrusion force to the inner wall of the artificial blood vessel; optionally, the extrusion device 80 can have an independent driving structure to drive the extrusion device 80 to extend into and out of the artificial blood vessel, or the extrusion structure of the extrusion device 80 is connected to the solution tube 30 so as to drive the extrusion structure to extend into or out of the artificial blood vessel through the solution tube driving assembly 50; optionally, the extrusion device 80 performs extrusion synchronously during the process of coating the sponge with the collagen solution, and / or the extrusion device 80 extrudes the collagen slurry after the collagen solution coating is completed and the collagen solution reaches a semi-solidified state (this semi-solidified state can be formed naturally or accelerated by drying) to form a collagen slurry.

[0026] An embodiment of the present invention provides a coating device for the collagen endothelium of an artificial blood vessel, the coating device comprising an artificial blood vessel fixing part for fixing the artificial blood vessel, a solution output component for outputting collagen, a solution tube connected to the solution output component, one end of the solution tube is fixedly connected to the solution output component, and the other end extends to form a free end, the solution tube has a liquid outlet near the free end, and the solution output component can drive the collagen to flow to the liquid outlet along the extension direction of the solution tube; the coating device also comprises a sponge delivery structure and a solution tube driving component, the sponge delivery structure is used to install a sponge and the sponge can be sleeved on the outside of the liquid outlet of the solution tube, the solution tube driving component drives the part of the solution tube with the liquid outlet to move in a first direction, the first direction is the extension direction of the artificial blood vessel and The portion of the solution tube having the liquid outlet is coaxial with the artificial blood vessel. By driving the solution tube to move in a first direction, the solution tube can drive the sponge to extend into the artificial blood vessel and move along the extension direction of the artificial blood vessel. At the same time, the collagen solution flowing out of the liquid outlet is absorbed by the sponge and evenly applied to the inner wall of the artificial blood vessel. This coating device can automatically achieve the coating of the collagen endothelium, reducing labor costs, and can quickly achieve the coating of the collagen endothelium through one movement, thereby improving the coating efficiency of the collagen endothelium. Moreover, the coating device also includes an extrusion device, which can extend into the artificial blood vessel and extrude the inner wall coated with the collagen solution. The collagen endothelium formed under the action of the extrusion force can be more uniform and the combination of the collagen endothelium and the artificial blood vessel is also tighter.

[0027] In some embodiments, as Figure 3As shown, the sponge delivery structure 40 includes a sponge mounting structure 41 and a rotating motor 42. The sponge mounting structure 41 is used to install the sponge. The rotating motor 42 is connected to the sponge mounting structure 41 to drive the sponge mounting structure 41 to rotate, and the rotation center of the sponge mounting structure 41 is parallel to the first direction, so that the sponge mounting structure 41 can rotate to between the free end of the solution tube 30 and the artificial blood vessel. It can be understood that when the sponge mounting structure 41 is driven by the rotating motor 42 to move between the free end and the artificial blood vessel, the solution tube driving assembly 50 is used to make the solution tube 30 move in the first direction so that the free end can poke into the interior of the sponge so that the sponge is sheathed on the outside of the liquid outlet 31, and then the solution tube 30 is reversed to make the sponge and The sponge mounting structure 41 is separated. At this time, the rotating motor 42 drives the sponge mounting structure 41 to rotate again to move the sponge mounting structure 41 away from the position between the free end and the artificial blood vessel, so that the sponge mounting structure 41 will not block the movement of the solution tube 30. In this state, the solution tube 30 is driven by the solution tube driving assembly 50 to move in the first direction so that the solution tube 30 and the sponge are extended into the artificial blood vessel together and the collagen solution absorbed by the sponge is smeared on the inner wall of the artificial blood vessel. It should be noted that this structure can realize the complex movement of the sponge delivery structure 40 without controlling the sponge delivery structure 40. The puncture installation of the sponge is achieved by coordinating the movement of the solution tube in the first direction with the rotational movement of the sponge mounting structure 41, thereby reducing the control difficulty of the coating device.

[0028] Optionally, the portion of the solution tube 30 near the free end has a limiting structure, such as Figure 2 As shown, the liquid outlet 31 is located between the free end and the limiting structure. During the installation process, the limiting structure can prevent the sponge from continuing to slide along the solution tube 30, so that the sponge can be sleeved on the outside of the liquid outlet 31.

[0029] In some embodiments, as Figure 4As shown, the sponge mounting structure 41 includes: a mounting member 411 and an elastic baffle 412, the mounting member 411 surrounds and forms a mounting cavity 413 for mounting the sponge, in the first direction, the opening of the mounting cavity 413 is located on both sides of the mounting member 411, and at the same time, the elastic baffle 412 is detachably mounted in the mounting cavity 413, in the first direction, the elastic baffle 412 is located on the side of the mounting cavity 413 away from the free end of the solution tube 30, wherein the elastic baffle 412 is an annular member, and it can be understood that when the free end moves along the first direction and extends into the mounting cavity 413 to poke the sponge, the elastic baffle 412 abuts against the sponge to prevent the sponge from being ejected from the mounting cavity 413 The other side is moved out of the installation cavity 413, thereby improving the installation reliability of the solution tube 30 and the sponge, and because the elastic baffle 412 is a ring-shaped part, that is, the middle part of the elastic baffle 412 has a through hole, so that the solution tube 30 can pass through the through hole, thereby reducing the risk of movement interference between the solution tube 30 and the elastic baffle 412, and the elastic baffle 412 can be elastically deformed in the radial direction of the installation cavity 413. Through the elastic deformation of the elastic baffle 412, the elastic baffle 412 can better form an interference fit with the inner wall of the accommodating cavity 413, which not only improves the installation reliability of the elastic baffle 412 but also improves the convenience of disassembly and assembly of the elastic baffle 412.

[0030] In some embodiments, as Figure 5 As shown, the coating device also includes a drying device 60, which includes a drying shell 61, and the drying shell 61 surrounds a drying chamber 611. The artificial blood vessel fixing part 10 is located in the drying chamber 611. After the collagen is coated on the inner wall of the artificial blood vessel through the sponge, the collagen solution on the inner wall of the artificial blood vessel is dried and solidified by the drying device 60, so that the collagen solution is reliably fixed to the inner wall of the artificial blood vessel. Optionally, the drying device 60 includes a hot air blower 62, which can dry the collagen solution on the inner wall of the artificial blood vessel by blowing hot air into the artificial blood vessel. Optionally, the drying device 60 can also include a heating wire arranged on the inner wall of the drying shell 61, so as to dry the collagen solution from the outside of the artificial blood vessel by heat radiation.

[0031] At the same time, the drying shell 61 has a communication port 612 connected to the drying chamber 611. The communication port 612 is located between the free end of the solution tube 30 and the artificial blood vessel fixing member 10, so that the free end of the solution tube 30 can extend into the artificial blood vessel in the drying chamber 611 through the communication port 612.

[0032] In some embodiments, as Figure 6 As shown, the coating device further includes a blocking member 71 and a blocking member driving structure 72. The blocking member driving structure 72 is used to drive the blocking member 71 to move between a first position and a second position. In the first position, the blocking member 71 can block the Figure 5Regarding the communication port 612 in the drying chamber, the blocking member 71 is in the second position and removes the blockage from the communication port 612. This can be understood as follows: during the drying process, the blocking member 71 is moved to the first position to block the communication port 612, reducing the amount of heat within the drying chamber 611 that leaks through the communication port 612, thereby improving drying efficiency; after drying, the blocking member 71 is moved to the second position to remove the blockage from the communication port 612, allowing the free end of the solution tube 30 to drive the sponge into the artificial blood vessel and achieve the next application of collagen solution. It should be noted that the blocking member driving structure 72 can move the blocking member 71 between the first position and the second position by any means. For example, the blocking member driving structure 72 can move horizontally in a direction perpendicular to the first direction, thereby moving the blocking member 71 between the first position and the second position.

[0033] Optional, such as Figure 3 As shown, the sponge delivery structure 40 also includes a rotating frame 43, which is connected to the rotating motor 42, and the rotation axis of the rotating frame 43 is parallel to the first direction, wherein the sponge mounting structure 41 and the sealing member 71 are arranged at intervals along the circumference of the rotating frame 43, and the sealing member can be rotated to the first position to achieve the sealing of the connecting port 612 by the sealing member 71, that is, the sponge mounting structure 41 and the sealing member 71 are both driven by the rotating motor 42, and the rotating motor 42 also has the function of the sealing member driving structure, thereby making the structure of the coating device more compact. Optionally, multiple sponge mounting structures 41 and multiple blocking members 71 are arranged at intervals around the rotating frame 43, and the blocking member 71 is located between two adjacent sponge mounting structures 41, so that the rotating motor 42 can respectively achieve the function of placing the sponge between the free end and the connecting port and the function of blocking the connecting port through a smaller rotation angle. Exemplarily, the number of sponge mounting structures 41 and blocking members 71 is 4, and the sponge mounting structures 41 and blocking members 71 are evenly distributed on the circumference of the rotating frame 43, so that the line connecting the geometric center points of the adjacent sponge mounting structures 41 and the rotating frame 43 is the same as the line connecting the geometric center points of the blocking member 71 and the rotating frame 43. The angle between them is 45 degrees. After a sponge mounting structure 41 places the sponge between the solution tube and the connecting port 611 and installs the solution tube with the sponge by puncturing, the rotating motor 42 drives the rotating frame 43 to rotate 22.5 degrees, so that the solution tube can extend into the artificial blood vessel along the first direction and coat the collagen solution on the inner wall of the artificial blood vessel, and then drives the rotating frame 43 to rotate 22.5 degrees to allow the sealing member 71 to seal the connecting port and dry the artificial blood vessel. After drying is completed, the rotating frame 43 is driven to rotate 45 degrees so that another sponge mounting structure 41 is located between the free single and the connecting port to realize the puncture installation of the next sponge and the solution tube 30.

[0034] In some embodiments, as Figure 7As shown, the solution output component 20 includes an injection syringe 21 and a drive syringe 22. The injection syringe 21 contains a collagen solution and is connected to the solution tube 30, and is used to output a certain amount of collagen solution into the solution tube 30. The drive syringe 22 is connected to the solution tube 30. The movement of the piston of the drive syringe 22 can drive the collagen solution to move along the extension direction of the solution tube 30 and flow out from the liquid outlet 31. After the injection syringe 21 completes the output of the collagen solution, the position of its piston is fixed. After the piston of the drive syringe 22 is driven, the piston of the drive syringe 22 needs to be reset. At this time, since the position of the piston of the injection syringe 21 is fixed, under the action of the internal air pressure of the injection syringe 21, the collagen solution in the injection syringe 21 will not be sucked into the solution tube 30 during the reset process of the piston of the drive syringe 22. During the reset process, the drive syringe 22 will only suck air into the solution tube 30 through the liquid outlet 31.

[0035] In some embodiments, as Figure 8 As shown, the coating device also includes an expansion structure 81, a driving structure 82 and an air supply component 83. The expansion structure 81 can generate elastic deformation, which can make the expansion structure 81 expand or contract. The driving structure 82 is connected to the expansion structure 81, and the driving structure 82 can drive the expansion structure 81 to extend into or move out of the artificial blood vessel. The air supply component 83 is connected to the expansion structure and is used to expand the expansion structure. Specifically, after the collagen solution is coated on the inner wall of the artificial blood vessel through the sponge, the collagen solution in the artificial blood vessel is preliminarily dried by the drying device 60 to form a semi-solidified collagen solution. In this case, the expansion structure 81 is extended into the artificial blood vessel and an extrusion force is applied to the slurry through the expansion of the expansion structure 81. Since the slurry is in a semi-solidified state after its fluidity is reduced, it can more easily maintain its extruded shape after being squeezed by the expansion structure 81, that is, it can be kept in a more evenly distributed state. After the extrusion is completed, the expansion structure 81 is removed from the artificial blood vessel, and the artificial blood vessel is continued to be dried by the drying device 60, so that the slurry that is evenly distributed and more tightly combined with the inner wall continues to be dried, thereby forming a collagen endothelium that is more evenly distributed and more tightly combined with the inner wall.

[0036] Optional, such as Figure 9As shown, the air supply assembly 83 includes an air supply syringe 831, an air supply pipe 832, an injector driver 833 and a pressure gauge 834. The injector driver 832 can drive the piston movement of the air supply syringe 831. The air supply syringe 831 is connected to the air supply pipe 832 and the air supply pipe 832 is connected to the expansion structure 81, so that the air supply syringe 831 can control the expansion and contraction of the expansion structure 81 through the movement of the piston. The pressure gauge 834 is connected to the air supply pipe 832, so that the pressure data in the air supply pipe 832 can be obtained through the pressure gauge 834, and the air pressure in the air supply pipe 832 can be accurately controlled.

[0037] Optionally, the driving structure 82 may be a driving structure independent of the solution tube driving assembly 50 , and the two driving structures may avoid each other by moving in a direction perpendicular to the second direction, thereby reducing the risk of motion interference between the two driving structures.

[0038] In some embodiments, as Figure 10 As shown, the expansion structure 81 is sleeved on the outside of the solution tube 30, so that the expansion structure 81 can move in the first direction together with the solution tube 30. The solution tube drive assembly 50 can also have Figure 8 The function of the driving structure 82 is utilized to make the structure of the coating device more compact. Moreover, when the sponge enters the artificial blood vessel along with the solution tube 30, the expansion structure 81 also enters the artificial blood vessel. Optionally, when the sponge coats the collagen solution on the inner wall of the artificial blood vessel, the expansion structure 81 can be in an expanded state, so that the expansion structure 81 can simultaneously press the collagen solution to the inner wall of the artificial blood vessel, thereby making the collagen solution evenly distributed before starting to flow freely, further improving the uniformity of the coating of the collagen solution.

[0039] Optional, such as Figure 11 As shown, in the first direction, the two expansion structures 81 are spaced apart. When the expansion structures 81 extend into the artificial blood vessel, the two expansion structures 81 and the inner wall of the artificial blood vessel form a closed space, so that the collagen slurry in a semi-solidified state is confined within the closed space. The two expansion structures can squeeze the collagen slurry in the closed space toward the inner wall of the artificial blood vessel, thereby further improving the degree of bonding between the collagen solution and the artificial blood vessel.

[0040] In some embodiments, as Figure 5As shown, the coating device also includes an artificial blood vessel rotating structure 63, which is connected to the artificial blood vessel fixing part 10 and is used to drive the artificial blood vessel fixing part 10 to drive the artificial blood vessel to rotate, and the rotation axis of the artificial blood vessel fixing part 10 is parallel to the first direction. It can be understood that in order to prevent the collagen solution from flowing under its own gravity during the baking process, resulting in uneven distribution of the collagen solution after solidification, the artificial blood vessel is driven to rotate by the artificial blood vessel rotating structure 63 during the baking process, so that the distribution of the collagen endothelium is more uniform, and the thickness distribution of the collagen endothelium is further uniform.

[0041] In some other embodiments, the driving structure of the solution tube driving assembly can be a linear motor, or a driving assembly including a rotary drive motor and a screw structure; the driving structure for driving the piston of the syringe 22 can be a linear motor, or a driving assembly including a rotary drive motor and a screw structure; the air supply of the air supply assembly can be achieved by an air pump, or by the piston movement of the syringe, and the structure for driving the piston movement can be a linear motor, or a driving assembly including a rotary drive motor and a screw structure. The structure of the driving assembly including the rotary drive motor and the screw structure is exemplarily described below, as shown in FIG. Figure 12 As shown, the driving assembly includes: a base 91, a rotation drive motor 92, a slider 93, a guide rod 94 and a screw rod 95. The shell of the rotation drive motor 92 is fixedly connected to the base 91, and the guide rod 94 is fixedly connected to the base 91. At the same time, the screw rod 95 is connected to the output shaft of the rotation drive motor 92 to rotate under the drive of the rotation drive motor 92. The slider 93 has a through hole and a threaded hole. The threaded hole is sleeved on the outside of the screw rod 95, and the through hole is sleeved on the outside of the guide rod 94. The guide rod 94 can limit the rotation of the slider 93 relative to the screw rod 95, so that the rotation of the screw rod 95 can drive the slider 93 to slide along the extension direction of the screw rod 95. When the slider 93 is connected to the solution tube 30, the slider 93 can drive the solution tube 30 to move in the first direction. When the slider 93 is connected to the piston of the syringe, the slider 93 can drive the piston to move, thereby realizing the driving of the collagen solution or the driving of the pressurized gas.

[0042] The above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A coating device for artificial blood vessel collagen lining, characterized in that: The coating device comprises: an artificial blood vessel fixing member, used for fixing the artificial blood vessel; A solution output component, used for outputting collagen solution; a solution tube, connected to the solution output assembly, the solution tube extending to form a free end, the solution tube being provided with a solution outlet near the free end, and the portion of the solution tube having the outlet being coaxially disposed with the artificial blood vessel; A sponge delivery structure, used for installing a sponge, wherein the sponge can be sleeved on the outside of the liquid outlet; a solution tube drive assembly connected to the solution tube and configured to drive a portion of the solution tube having a liquid outlet to move in a first direction, wherein the first direction is parallel to a length direction of the artificial blood vessel; The squeezing device can extend into the artificial blood vessel and squeeze the inner wall of the artificial blood vessel.

2. The coating device according to claim 1, characterized in that The extrusion device comprises: Expansion structure, capable of elastic deformation; a driving structure, configured to drive the expansion structure to move into or out of the artificial blood vessel; An air supply assembly is communicated with the expansion structure and is used to expand the expansion structure.

3. The coating device according to claim 2, characterized in that The expansion structure is sleeved on the outside of the solution tube; Wherein, the driving structure is the solution tube driving assembly.

4. The coating device according to claim 1, characterized in that The sponge delivery structure includes: A sponge mounting structure, used for mounting the sponge; a rotating motor connected to the sponge mounting structure and configured to drive the sponge mounting structure to rotate; Wherein, the rotation axis of the sponge mounting structure is parallel to the first direction, and the sponge mounting structure can be rotated to between the free end and the artificial blood vessel.

5. The coating device according to claim 4, characterized in that The sponge mounting structure includes: A mounting member, enclosing and forming a mounting cavity for mounting the sponge, wherein openings of the mounting cavity are located on both sides of the mounting member in the first direction; an elastic baffle, detachably mounted in the mounting cavity and located on a side of the mounting cavity away from the free end in a first direction; Wherein, the elastic baffle is a ring-shaped member, and the elastic baffle can generate elastic deformation in the radial direction of the installation cavity.

6. The coating device according to claim 4, characterized in that The coating device further comprises a drying device, wherein the drying device has a drying chamber therein; The artificial blood vessel fixing piece is located in the drying chamber, the drying device has a communication port communicating with the drying chamber, and the communication port is located between the free end and the artificial blood vessel fixing piece.

7. The coating device according to claim 6, characterized in that The coating device further comprises: The artificial blood vessel rotating structure is connected to the artificial blood vessel fixing member and is used to drive the artificial blood vessel fixing member to rotate and drive the artificial blood vessel to rotate. The rotation axis of the artificial blood vessel fixing member is parallel to the first direction.

8. The coating device according to claim 7, characterized in that The coating device further comprises: Blocking parts; The blocking member driving structure is used to drive the blocking member to move between a first position and a second position. At the first position, the blocking member blocks the communication port. At the second position, the blocking member removes the blockage of the communication port.

9. The coating device according to claim 8, characterized in that The sponge delivery structure also includes: a rotating frame connected to the rotating motor, wherein the rotating axis of the rotating frame is parallel to the first direction; The sponge mounting structure and the blocking member are spaced apart along the circumference of the rotating frame, and the blocking member can rotate to the first position.

10. The coating device according to claim 1, characterized in that The solution output assembly comprises: an injection syringe containing the collagen solution and connected to the solution tube, for outputting the collagen solution into the solution tube; A driving syringe is connected to the solution tube and is used to drive the collagen solution to move along the extension direction of the solution tube.

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