Toothpaste for efficiently removing dental calculus and preparation method thereof

Abstract

The invention provides toothpaste for efficiently removing dental calculus and a preparation method thereof, and belongs to the technical field of oral care materials. The invention provides toothpaste capable of efficiently removing dental calculi. The toothpaste is prepared from an anti-anaerobe drug, sodium phytate, phosphate, nano hexagonal boron nitride, organic peroxide, beta-cyclodextrin, a slow release agent, silicon dioxide, a fluorine ion source and a carrier. The preparation method comprises the following steps: carrying out ultrasonic treatment on the nano hexagonal boron nitride, carrying out grinding and inclusion on the organic peroxide and the beta-cyclodextrin, and carrying out multi-step mixing and stirring. According to the toothpaste capable of efficiently removing the dental calculus and the preparation method of the toothpaste, the technical problems that in the prior art, the dental calculus removing efficiency is low, tooth enamel is abraded, oral mucosa is stimulated, and the toothpaste stability is poor are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of oral care materials, and in particular to a toothpaste for efficiently removing dental calculus and a preparation method thereof. Background Art

[0002] Dental tartar is a common oral disease, and its formation is related to a variety of factors, including oral hygiene habits and dietary habits. Dental tartar not only affects appearance but can also cause oral diseases such as gingivitis and periodontitis, posing a threat to oral health. With the improvement of people's living standards and the strengthening of oral health awareness, consumers are increasingly demanding toothpaste with efficient stain removal capabilities. However, traditional toothpastes primarily use abrasives and foaming agents to clean the tooth surface, which has limited effectiveness in removing tartar and makes it difficult to meet consumers' demand for efficient tartar removal.

[0003] In order to enhance the stain removal effect of toothpaste, the existing technology has proposed some improvement schemes. For example, some toothpastes have added biotechnology ingredients such as biological enzymes and probiotics to dissolve or inhibit the formation of dental plaque; some toothpastes have adopted new physical technologies, such as ultrasound and laser, to remove dental plaque more efficiently. However, these technical solutions still have some problems in practical application. On the one hand, some toothpaste ingredients may cause wear on tooth enamel, and long-term use may damage dental health; on the other hand, some toothpastes may irritate the oral mucosa, causing oral discomfort or allergic reactions. In addition, there are some toothpaste products on the market that are exaggerated, have unsafe ingredients, and are counterfeit and inferior, which bring troubles to consumers' choices.

[0004] The present invention provides a toothpaste for efficiently removing dental calculus and a preparation method thereof, which achieves the effect of efficiently removing dental calculus by combining ingredients such as nano hexagonal boron nitride, organic peroxide, phosphate, a sustained-release agent and magnesium aluminum silicate. Summary of the Invention

[0005] The present invention provides a toothpaste for efficiently removing dental calculus and a preparation method thereof, which are used to solve the technical problems in the prior art of low dental calculus removal efficiency, wear on tooth enamel, irritation to oral mucosa and poor stability of toothpaste.

[0006] In one aspect, the present invention provides a toothpaste for efficiently removing dental calculus, comprising the following components: Anti-anaerobic drugs 0.005%~3%; Sodium phytate 0.1%~6%; Phosphate 3%~8%; Nano hexagonal boron nitride 0.05%~2%; Organic peroxide 0.1%~3%; β-cyclodextrin 0.1%~3%; Sustained-release agent 0.05%~2%; Silicon dioxide 3%~35%; Fluoride ion source 0.03%~1%; The remainder is the carrier; The pH value of the toothpaste is 7.5-10.5; The particle size of the nano hexagonal boron nitride is 20-800 nm.

[0007] According to the present invention, a toothpaste for efficiently removing dental calculus is provided, wherein the carrier comprises the following components: Glycerol 8%~15%; Sorbitol solution 25%~38%; Xanthan gum 0.4%~1.2%; Magnesium aluminum silicate 0.3%~1%; Sodium lauryl sulfate 0.5%~2%; Polybutene 0.3%~1.8%; Sodium hydroxide solution 0.3%~1.5%; Saccharin sodium 0.05%~0.5%; Mint flavor 0.3%~1.5%; Titanium dioxide 0.2%~1%; The balance is deionized water; The concentration of the sodium hydroxide solution is 10%.

[0008] According to the toothpaste for efficiently removing dental calculus provided by the present invention, the anti-anaerobic drug is one or more of tinidazole, ornidazole, and metronidazole benzoate.

[0009] According to the toothpaste for efficiently removing dental calculus provided by the present invention, the phosphate is one or more of sodium tripolyphosphate, tetrapotassium pyrophosphate, and sodium hexametaphosphate.

[0010] According to the toothpaste for efficiently removing dental calculus provided by the present invention, the organic peroxide is one or more of phthalimidoperoxycaproic acid, urea peroxide, and potassium peroxymonosulfate.

[0011] According to the toothpaste for efficiently removing dental calculus provided by the present invention, the sustained-release agent is one or more of maleic anhydride-ethylene copolymer, polyvinyl pyrrolidone, and chitosan quaternary ammonium salt.

[0012] According to the toothpaste for efficiently removing dental calculus provided by the present invention, the fluoride ion source is one or more of sodium fluoride, sodium monofluorophosphate, and stannous fluoride.

[0013] On the other hand, the present invention also provides a method for preparing a toothpaste for efficiently removing dental calculus, which is characterized by comprising the following steps: (1) Adding nano-hexagonal boron nitride to glycerol and ultrasonically treating the mixture to obtain a dispersion; (2) mixing the organic peroxide with β-cyclodextrin and grinding to form an inclusion compound; (3) Mixing deionized water, sorbitol solution, sodium phytate, and a fluoride ion source, and adding sodium hydroxide to adjust the pH to 9 to obtain an aqueous phase; (4) mixing polybutene, magnesium aluminum silicate, xanthan gum and a sustained-release agent to obtain an oil phase; (5) Add the oil phase to the 60°C water phase and homogenize and emulsify. After cooling to 40°C, add phosphate, dispersion and inclusion compound and stir to mix. (6) Add anti-anaerobic drugs, silicon dioxide, sodium lauryl sulfate, sodium saccharin, mint essence and titanium dioxide, stir, vacuum degas, and then fill to obtain a toothpaste that is highly effective in removing dental calculus.

[0014] According to the method for preparing a toothpaste for efficiently removing dental calculus provided by the present invention, in step (1), the frequency of the ultrasonic treatment is 30-50 kHz, and the ultrasonic treatment time is 20-40 minutes; In step (5), the speed of the homogenization and emulsification is 1500-2500 rpm, and the time of the homogenization and emulsification is 5-30 min; In step (6), the rotation speed of the stirring treatment is 300~1200 rpm, the stirring treatment time is 5~20 min, the vacuum degassing pressure is -0.05~-0.1 MPa, and the vacuum degassing time is 3~15 min.

[0015] According to the method for preparing a toothpaste for efficiently removing dental calculus provided by the present invention, silicon dioxide and titanium dioxide are premixed before adding silicon dioxide.

[0016] The present invention provides a toothpaste for efficiently removing dental calculus and a preparation method thereof. By combining specific components such as nano hexagonal boron nitride, organic peroxide, phosphate, a sustained-release agent and magnesium aluminum silicate, and adopting a specific preparation method of adding nano hexagonal boron nitride to glycerin for ultrasonic treatment, mixing and grinding the organic peroxide with β-cyclodextrin to form an inclusion complex, and multi-step mixing and stirring, the technical problems of low dental calculus removal efficiency, wear on tooth enamel, irritation to oral mucosa and poor stability of toothpaste in the prior art are solved. The technical effects of significantly improving the dental calculus removal rate, effectively inhibiting plaque formation, significantly extending the stability of toothpaste ingredients, greatly reducing enamel wear and mucosal irritation, and the toothpaste having excellent emulsification, stable pH value, stable paste, and easy mechanical stirring and vacuum degassing are achieved. DETAILED DESCRIPTION

[0017] The present invention provides a toothpaste for removing dental calculus efficiently, comprising: 0.005% to 3%, preferably 0.5% to 1.5%, more preferably 0.75% to 1% of an anti-anaerobic drug; 0.1% to 6%, preferably 0.5% to 3%, more preferably 1% to 1% of sodium phytate; %~2%; phosphate 3%~8%, preferably 4%~6%, more preferably 4.5%~5.5%; nano hexagonal boron nitride 0.05%~2%, preferably 0.1%~1%, more preferably 0.25%~0.75%; organic peroxide 0.1%~3%, preferably 0.5%~1.5%, more preferably 0.8%~1.2%; β-cyclodextrin 0.1%~3%, preferably 0.5%~1.5%, more preferably 0.8%~1.2%; sustained-release agent 0.05%~2%, preferably 0.1%~1%, more preferably 0.25%~0.75%; silicon dioxide 3%~35%, preferably 10%~25%, more preferably 15%~20%; fluoride ion source 0.03%~1%, preferably 0.1%~0.5%, more preferably 0.22%~0.26%; the balance is carrier; The pH value of the toothpaste is 7.5-10.5, preferably 8-9.5, more preferably 8.5-9; The particle size of the nano hexagonal boron nitride is 20-800 nm, preferably 100-400 nm, and more preferably 150-300 nm.

[0018] In the present invention, the carrier comprises: 8% to 15% glycerol, preferably 10% to 12%; 25% to 38% sorbitol solution, preferably 28% to 32%; 0.4% to 1.2% xanthan gum, preferably 0.6% to 0.9%; 0.3% to 1% magnesium aluminum silicate, preferably 0.5% to 0.7%; 0.5% to 2% sodium lauryl sulfate, preferably 1% to 1.5%; 0.3% to 1.8% polybutene, preferably 0.8% to 1.2%; 0.3% to 1.5% sodium hydroxide solution, preferably 0.5% to 1%; 0.05% to 0.5% sodium saccharin, preferably 0.1% to 0.3%; 0.3% to 1.5% mint essence, preferably 0.6% to 1.2%; 0.2% to 1% titanium dioxide, preferably 0.4% to 0.6%; the balance is deionized water; and the concentration of the sodium hydroxide solution is 10%.

[0019] In the present invention, the anti-anaerobic drug is one or more of tinidazole, ornidazole, and metronidazole benzoate, preferably one of tinidazole, ornidazole, and metronidazole benzoate, and more preferably tinidazole or ornidazole.

[0020] In the present invention, the phosphate is one or more of sodium tripolyphosphate, tetrapotassium pyrophosphate, and sodium hexametaphosphate, preferably one of sodium tripolyphosphate, tetrapotassium pyrophosphate, and sodium hexametaphosphate, and more preferably sodium tripolyphosphate or tetrapotassium pyrophosphate.

[0021] In the present invention, the organic peroxide is one or more of phthalimidoperoxycaproic acid, urea peroxide, and potassium peroxymonosulfate, preferably one of phthalimidoperoxycaproic acid, urea peroxide, and potassium peroxymonosulfate, more preferably phthalimidoperoxycaproic acid or urea peroxide.

[0022] In the present invention, the sustained-release agent is one or more of maleic anhydride-ethylene copolymer, polyvinyl pyrrolidone, and chitosan quaternary ammonium salt, preferably one of maleic anhydride-ethylene copolymer, polyvinyl pyrrolidone, and chitosan quaternary ammonium salt, and more preferably maleic anhydride-ethylene copolymer or polyvinyl pyrrolidone.

[0023] In the present invention, the fluoride ion source is one or more of sodium fluoride, sodium monofluorophosphate, and stannous fluoride, preferably one of sodium fluoride, sodium monofluorophosphate, and stannous fluoride, and more preferably sodium fluoride or sodium monofluorophosphate.

[0024] On the other hand, the present invention also provides a method for preparing a toothpaste for efficiently removing dental calculus, which is characterized by comprising the following steps: (1) Adding nano-hexagonal boron nitride to glycerol and ultrasonically treating the mixture to obtain a dispersion; (2) mixing the organic peroxide with β-cyclodextrin and grinding to form an inclusion compound; (3) Mixing deionized water, sorbitol solution, sodium phytate, and a fluoride ion source, and adding sodium hydroxide to adjust the pH to 9 to obtain an aqueous phase; (4) mixing polybutene, magnesium aluminum silicate, xanthan gum and a sustained-release agent to obtain an oil phase; (5) Add the oil phase to the 60°C water phase and homogenize and emulsify. After cooling to 40°C, add phosphate, dispersion and inclusion compound and stir to mix. (6) Add anti-anaerobic drugs, silicon dioxide, sodium lauryl sulfate, sodium saccharin, mint essence and titanium dioxide, stir, vacuum degas, and then fill to obtain a toothpaste that is highly effective in removing dental calculus.

[0025] In the present invention, in step (1), the frequency of the ultrasonic treatment is 30-50 kHz, preferably 35-45 kHz, more preferably 38-42 kHz; the time of the ultrasonic treatment is 20-40 min, preferably 25-35 min, more preferably 28-42 min; in step (5), the speed of the homogenization and emulsification is 1500-2500 rpm, preferably 1700-2300 rpm, more preferably 1900-2100 rpm; the time of the homogenization and emulsification is 5-30 min, preferably 10-20 min, more preferably 12-15 min n; in step (6), the rotation speed of the stirring treatment is 300~1200 rpm, preferably 500~1000 rpm, and more preferably 700~800 rpm; the stirring treatment time is 5~20 min, preferably 10~15 min, and more preferably 12~13 min; the vacuum degassing pressure is -0.05~-0.1 MPa, preferably -0.07~-0.085 MPa, and more preferably -0.075~-0.08 MPa; the vacuum degassing time is 3~15 min, preferably 5~10 min, and more preferably 7~8 min.

[0026] In the present invention, silicon dioxide and titanium dioxide are premixed before adding silicon dioxide.

[0027] The technical solutions provided by the present invention are described in detail with reference to the embodiments, but they should not be understood as limiting the scope of protection of the present invention.

[0028] Example 1 3 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 6 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 437.5 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 1.5 g of sodium fluoride were mixed, and 8 g of 10% sodium hydroxide solution was added to adjust the pH to 8.5 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 40g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 800 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 8 min and then filled to obtain a toothpaste that is highly effective in removing dental calculus.

[0029] Example 2 5 g of nano-hexagonal boron nitride (particle size 150 nm) was added to 110 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 10 g of phthalimidoperoxycaproic acid was mixed with 6 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 422.5 g of deionized water, 280 g of sorbitol solution, 20 g of sodium phytate, and 1.5 g of sodium fluoride were mixed, and 8 g of 10% sodium hydroxide solution was added to adjust the pH to 8.5 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 6 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 800 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 8 min and then filled to obtain a toothpaste that is highly effective in removing dental calculus.

[0030] Example 3 5 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 417.1 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 2.4 g of sodium fluoride were mixed, and 9.5 g of 10% sodium hydroxide solution was added to adjust the pH to 8.8 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 7.5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste that is highly effective in removing dental calculus.

[0031] Example 4 5 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 417.1 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 2.4 g of sodium fluoride were mixed, and 9.5 g of 10% sodium hydroxide solution was added to adjust the pH to 8.8 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 7.5 g of ornidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste that is highly effective in removing dental calculus.

[0032] Example 5 5 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 417.1 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 2.4 g of sodium fluoride were mixed, and 9.5 g of 10% sodium hydroxide solution was added to adjust the pH to 8.8 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum, and 4 g of chitosan quaternary ammonium salt were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 7.5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste that is highly effective in removing dental calculus.

[0033] Comparative Example 1 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 422.1 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 2.4 g of sodium fluoride were mixed, and 9.5 g of 10% sodium hydroxide solution was added to adjust the pH to 8.8 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, 100g of glycerol and the inclusion compound, and stir to mix; A premix of 7.5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste.

[0034] Comparative Example 2 5 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 424.6 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 2.4 g of sodium fluoride were mixed, and 2 g of 10% sodium hydroxide solution was added to adjust the pH to 7 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 7.5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of silicon dioxide was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste.

[0035] Comparative Example 3 5 g of nano-hexagonal boron nitride (particle size 200 nm) was added to 100 g of glycerol and ultrasonicated at a frequency of 40 kHz for 30 min to obtain a dispersion; 6 g of phthalimidoperoxycaproic acid was mixed with 10 g of β-cyclodextrin and ground for 20 min to form an inclusion complex; 411.9 g of deionized water, 280 g of sorbitol solution, 15 g of sodium phytate, and 7.6 g of sodium monofluorophosphate were mixed, and 9.5 g of 10% sodium hydroxide solution was added to adjust the pH to 8.8 to obtain an aqueous phase; 10 g of polybutene (MW = 1200), 5 g of magnesium aluminum silicate, 7 g of xanthan gum and 4 g of maleic anhydride-ethylene copolymer were mixed to obtain an oil phase; Add the oil phase to the 60°C water phase, homogenize and emulsify at 2000 rpm for 15 minutes, cool to 40°C, add 50g of sodium tripolyphosphate, dispersion and inclusion compound, and stir to mix; A premix of 7.5 g of tinidazole, 12 g of sodium lauryl sulfate, 2 g of sodium saccharin, 9 g of mint essence, 5 g of titanium dioxide, and 150 g of calcium carbonate was added and stirred at 750 rpm for 12 min. The mixture was vacuum degassed at a pressure of -0.08 MPa for 7.5 min and then filled to obtain a toothpaste.

[0036] The products of Examples 1 to 5 and Comparative Examples 1 to 3 were tested, and their properties are shown in Table 1.

[0037] Table 1 Laboratory evaluation report on comprehensive performance of highly effective tartar removal toothpaste

[0038] Comparison of Example 3 and Comparative Example 1 shows that the calculus removal rate of Comparative Example 1 decreased by 20% compared to Example 3. Analysis suggests that the physical scale barrier is lost due to the absence of nano hexagonal boron nitride, resulting in a lower calculus removal rate due to chemical dissolution alone.

[0039] Comparative Example 2 shows that sodium tripolyphosphate degrades by 31.6% at pH 7.0. Under acidic conditions, sodium tripolyphosphate hydrolyzes to form orthophosphate, losing its chelating ability. This demonstrates the necessity of an alkaline environment.

[0040] Comparison of Example 3 and Comparative Example 3 shows that the enamel wear depth in Comparative Example 3 increased by 288% compared to Example 3. Analysis suggests that the CaF2 particles generated by the calcium carbonate and sodium fluoride in Comparative Example 3, which have a Mohs hardness of 4.0, cause enamel scratches. Furthermore, the CaF2 particles mechanically damage the mucosa, causing moderate irritation.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A toothpaste for effectively removing dental calculus, characterized in that: Contains the following components: Anti-anaerobic drugs 0.005%~3.0%; Sodium phytate 0.1%~6%; Phosphate 3%~8%; Nano hexagonal boron nitride 0.05%~2%; Organic peroxide 0.1%~3%; β-cyclodextrin 0.1%~3%; Sustained-release agent 0.05%~2%; Silicon dioxide 3%~35%; Fluoride ion source 0.03%~1%; The remainder is the carrier; The pH value of the toothpaste is 7.5-10.5; The particle size of the nano hexagonal boron nitride is 20-800 nm.

2. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The carrier comprises the following components: Glycerol 8%~15%; Sorbitol solution 25%~38%; Xanthan gum 0.4%~1.2%; Magnesium aluminum silicate 0.3%~1%; Sodium lauryl sulfate 0.5%~2%; Polybutene 0.3%~1.8%; Sodium hydroxide solution 0.3%~1.5%; Saccharin sodium 0.05%~0.5%; Mint flavor 0.3%~1.5%; Titanium dioxide 0.2%~1%; The balance is deionized water; The concentration of the sodium hydroxide solution is 10%.

3. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The anti-anaerobic drug is one or more of tinidazole, ornidazole, and metronidazole benzoate.

4. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The phosphate is one or more of sodium tripolyphosphate, tetrapotassium pyrophosphate, and sodium hexametaphosphate.

5. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The organic peroxide is one or more of phthalimidoperoxycaproic acid, urea peroxide, and potassium peroxymonosulfate.

6. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The sustained-release agent is one or more of maleic anhydride-ethylene copolymer, polyvinyl pyrrolidone, and chitosan quaternary ammonium salt.

7. The toothpaste for efficiently removing dental calculus according to claim 1, characterized in that: The fluoride ion source is one or more of sodium fluoride, sodium monofluorophosphate, and stannous fluoride.

8. A method for preparing a toothpaste for effectively removing dental calculus, characterized in that: The following steps are involved: (1) Adding nano-hexagonal boron nitride to glycerol and ultrasonically treating the mixture to obtain a dispersion; (2) mixing the organic peroxide with β-cyclodextrin and grinding to form an inclusion compound; (3) Mixing deionized water, sorbitol solution, sodium phytate, and a fluoride ion source, and adding sodium hydroxide to adjust the pH to 9 to obtain an aqueous phase; (4) mixing polybutene, magnesium aluminum silicate, xanthan gum and a sustained-release agent to obtain an oil phase; (5) Add the oil phase to the 60°C water phase and homogenize and emulsify. After cooling to 40°C, add phosphate, dispersion and inclusion compound and stir to mix. (6) Add anti-anaerobic drugs, silicon dioxide, sodium lauryl sulfate, sodium saccharin, mint essence and titanium dioxide, stir, vacuum degas, and then fill to obtain a toothpaste that is highly effective in removing dental calculus.

9. The method for preparing a toothpaste for efficiently removing dental calculus according to claim 8, characterized in that: In step (1), the frequency of the ultrasonic treatment is 30-50 kHz, and the ultrasonic treatment time is 20-40 min; In step (5), the speed of the homogenization and emulsification is 1500-2500 rpm, and the time of the homogenization and emulsification is 5-30 min; In step (6), the rotation speed of the stirring treatment is 300~1200 rpm, the stirring treatment time is 5~20 min, the vacuum degassing pressure is -0.05~-0.1 MPa, and the vacuum degassing time is 3~15 min.

10. The method for preparing a toothpaste for efficiently removing dental calculus according to claim 8, characterized in that: Before adding silica, premix silica with titanium dioxide.

Images