Cleaning composition and skin cleaning product containing same

Abstract

The invention provides a cleaning composition. The cleaning composition comprises the following components in parts by weight: (i) 0.1-0.5 part of a soapberry fruit extract; (ii) 0.1-0.5 part of a camellia seed extract; (iii) 0.5-2 parts of low molecular weight hyaluronic acid; and (iv) 0.01 to 0.2 part of electrolyte. The present disclosure also provides a skin cleansing product comprising the cleansing composition. The cleaning composition provided by the invention not only can effectively clean grease and dirt on the skin surface, but also can improve the condition of grease accumulation in pores and dredge the pores, and in addition, can effectively protect a skin sebum film, tough a barrier and improve the water content of the skin, so that the skin is not dry after being washed, and is very friendly to sensitive skin and crispy skin.

Description

Technical Field

[0001] The present disclosure relates to the technical field of cleaning products, and in particular to a cleaning composition and a skin cleaning product containing the same. Background Art

[0002] Skin cleansing is a basic step in daily care. The principle of skin cleansing is to gently remove excess sebum, keratin and dirt on the skin surface without destroying the skin's normal lipid layer to avoid damaging the skin's barrier function, ensuring that the skin has sufficient moisture and preventing large molecules from penetrating the skin to cause irritation or allergic reactions.

[0003] Existing commercially available facial cleansing products are mainly divided into two categories: strong cleansing (such as foam cleansers containing soap bases and high concentrations of surfactants) and mild cleansing (such as amino acid surfactant cleansers and foam-free cleansing products). Among them, strong cleansing products use soap bases, sodium lauryl sulfate (SLS) and other ingredients as main ingredients. They have excellent cleaning power but strong degreasing ability, which can easily damage the sebum film on the skin surface (a natural barrier composed of oil secreted by sebaceous glands, keratinocyte lipids, etc.), causing dry and sensitive skin, and even triggering skin diseases related to impaired barrier function (such as atopic dermatitis and rosacea). Mild products often use low-irritation ingredients such as amino acid surfactants (such as potassium cocoyl glycinate) and APG (alkyl glycosides), or rely on the natural cleansing ability of plant extracts (such as soapberry saponins and tea saponins). Although they reduce damage to the sebum film, they generally have the problem of insufficient cleaning power (such as the inability to effectively remove oil, dirt and sunscreen residues on the skin surface), and their applicability is particularly limited for people with combination skin and oily skin.

[0004] With the increasing environmental pressure and the influence of factors such as excessive skin care, the proportion of people with sensitive skin has increased significantly (according to epidemiological surveys, the incidence of sensitive skin in Asian women is about 40% to 56%). This group of people has a weak skin barrier function and poor tolerance to traditional cleansing products. They are in urgent need of cleansing products with the following characteristics: (1) Mildness: Avoid excessive removal of key lipids in the sebum membrane (such as ceramides and cholesterol); (2) Effectiveness: Remove pollutants, excess oil and metabolic waste from the skin surface, especially the oil accumulated in the pores. Summary of the Invention

[0005] In response to the deficiencies in the prior art, the present disclosure provides a cleansing composition that has the characteristics of mild cleansing. It can not only effectively clean the grease and dirt on the skin surface, but also improve the accumulation of oil in the pores and unclog the pores. In addition, it can effectively protect the skin's sebum film, strengthen the barrier, and increase the skin's moisture content, so that the skin does not dry out after washing. It is very friendly to sensitive skin and brittle skin.

[0006] In a first aspect of the present disclosure, a cleaning composition is provided, comprising the following components in parts by weight:

[0007] (i) 0.1-0.5 parts of soapberry fruit extract;

[0008] (ii) 0.1-0.5 parts of camellia seed extract;

[0009] (iii) 0.5-2 parts of low molecular weight hyaluronic acid;

[0010] (iv) 0.01 to 0.2 parts of electrolyte.

[0011] Sapindus mukorossi fruit extract is extracted from the peel of mature Sapindus mukorossi fruit. Sapindus mukorossi fruit extract contains saponins, which have strong detergency and stable properties. It is an excellent natural nonionic surfactant that gently removes oil and keratin from the skin's surface, leaving it feeling refreshed.

[0012] Camellia japonica seed extract is extracted from the mature fruit of the camellia plant. Camellia seeds contain a variety of beneficial ingredients, such as tea polyphenols and tea saponins. Tea polyphenols have antioxidant properties, scavenging free radicals and reducing oxidative stress damage to the skin, helping to maintain normal skin function. Tea saponins, on the other hand, have surface-active properties that cleanse the skin and remove surface oil and dirt.

[0013] A combination of soapberry fruit extract and camellia seed extract has excellent cleansing properties, effectively removing grease and dirt from the skin's surface. For oily skin, excessive oil secretion can easily lead to excessive oil accumulation in pores, causing pore clogging. However, due to the large steric hindrance of saponin molecules, they are difficult to enter the pores and stratum corneum. Therefore, a combination of soapberry fruit extract and camellia seed extract is unable to remove accumulated oil in pores. Furthermore, long-term use can impair the skin's barrier function, leading to dry and sensitive skin.

[0014] In the present disclosure, a specific amount of low-molecular-weight hyaluronic acid is added to the cleaning composition, wherein the low-molecular-weight hyaluronic acid has a smaller molecular structure and can more easily penetrate the stratum corneum of the skin. It can serve as a carrier to help the two extracts, soapberry fruit extract and camellia seed extract, penetrate deeper into the pores, so that they can be closer to the oil in the pores, thereby more effectively playing its role in cleaning and removing oil. Secondly, low-molecular-weight hyaluronic acid has the function of moisturizing and regulating the water-oil balance of the skin. It can reduce the secretion of skin oil, thereby reducing the accumulation of oil in the pores; it can also keep the stratum corneum of the skin moisturized, make the skin cells around the pores healthier, and contribute to the natural expansion and contraction of the pores, thereby making it easier for the soapberry extract and camellia seed extract to play their cleaning role and bring out the oil in the pores. Again, low molecular weight hyaluronic acid can penetrate deep into the stratum corneum of the skin. Its powerful water absorption and water-locking ability can keep the stratum corneum sufficiently hydrated, making the skin cells plump, thereby enhancing the skin's barrier function; it can also promote the proliferation and differentiation of skin cells, accelerate the shedding of aging keratinocytes, and speed up the renewal of skin cells, thereby helping to maintain the normal structure and function of the skin barrier.

[0015] Electrolytes play an important role in the functioning of the skin. They can maintain the skin's moisture balance, stabilize the skin's barrier function, and participate in skin cell metabolism. During the skin cleansing process, some electrolytes are lost, causing local electrolyte imbalance in the skin and affecting the skin's barrier function. Therefore, in the present disclosure, a specific amount of electrolytes is added to the cleansing composition to replenish the electrolytes lost by the skin during cleansing. The electrolytes and low molecular weight hyaluronic acid can produce a synergistic effect, better regulating skin oil secretion, protecting the skin's sebum film, strengthening the barrier, and increasing the skin's moisture content, so that the skin does not dry out after washing.

[0016] In the cleaning composition disclosed herein, the content of the soapberry fruit extract is 0.1 to 0.5 parts, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 parts, etc.

[0017] In the cleaning composition disclosed herein, the camellia seed extract may be present in an amount of 0.1 to 0.5 parts, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 parts, and the like.

[0018] In the cleansing composition of the present disclosure, the content of low molecular weight hyaluronic acid is 0.5 to 2 parts, for example, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.5, 1.6, 1.8, 2.0 parts, etc.

[0019] In the cleaning composition of the present disclosure, the content of the electrolyte is 0.01 to 0.2 parts, for example, 0.01, 0.02, 0.04, 0.05, 0.06, 0.08, 0.1, 0.12, 0.14, 0.15, 0.16, 0.18, 0.2 parts, etc.

[0020] Furthermore, in the cleansing composition of the present disclosure, the low molecular weight hyaluronic acid has a molecular weight of 10 to 50 kDa, for example, 10, 20, 30, 40, 50 kDa, etc. Compared with hyaluronic acid of conventional molecular weight, low molecular weight hyaluronic acid has a smaller molecular structure and can more easily penetrate the stratum corneum of the skin, thereby helping the cleansing ingredients penetrate into the stratum corneum and pores, and improving the removal of oil accumulated in the pores.

[0021] Furthermore, in the cleaning composition of the present disclosure, the electrolyte includes at least sodium chloride and dipotassium glycyrrhizate.

[0022] Sodium ions and potassium ions are the electrolytes with the highest content in the skin. Sodium is mainly in the intercellular fluid, and potassium is mainly in the cytoplasm. Both play an important role in maintaining the osmotic pressure and acid-base balance of tissue cells, repairing the skin barrier, and maintaining the function of the skin barrier.

[0023] Furthermore, in the electrolyte, the content of sodium chloride is 0.001 to 0.05 parts, for example, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05 parts; more preferably 0.001 to 0.005 parts. The content of dipotassium glycyrrhizate is 0.01 to 0.15 parts, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.12, 0.14, 0.15 parts; more preferably 0.02 to 0.1 parts.

[0024] Furthermore, the electrolyte further includes at least one of magnesium sulfate and calcium chloride.

[0025] The presence of magnesium ions not only prevents water loss from the skin but also significantly increases stratum corneum hydration. This is because magnesium salts are hygroscopic and bind water within their crystal lattice. Consequently, magnesium ions reside in the extracellular space of the stratum corneum, where they bind water through physicochemical interactions. Furthermore, magnesium ions can regulate epidermal proliferation, differentiation, and barrier function, indirectly affecting stratum corneum hydration.

[0026] In addition, calcium ions and magnesium ions play a key role in the homeostasis of the skin barrier. In normal skin, the concentrations of magnesium ions and calcium ions are higher in the upper layer of the epidermis. When the barrier is damaged by washing the skin, the calcium and magnesium gradients in the epidermis disappear, while the pH value does not change. The loss of ion gradients is a signal for increased proliferation, differentiation, and lipid synthesis, aimed at repairing the damaged barrier. Magnesium ions and calcium ions have a significant promoting effect on the recovery rate of the skin barrier after barrier damage, and can more effectively accelerate barrier repair. Preferably, the electrolyte includes magnesium sulfate and calcium chloride at the same time.

[0027] Furthermore, in the electrolyte, the content of magnesium sulfate and calcium chloride is 0.001 to 0.01 parts, for example, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, or 0.01 parts; more preferably 0.001 to 0.005 parts.

[0028] In one embodiment of the present disclosure, the cleaning composition comprises the following components in parts by weight:

[0029] (i) 0.1-0.2 parts of soapberry fruit extract;

[0030] (ii) 0.1-0.2 parts of camellia seed extract;

[0031] (iii) 1-2 parts of low molecular weight hyaluronic acid;

[0032] (iv) 0.02 to 0.1 parts of electrolyte.

[0033] In a preferred embodiment of the present disclosure, the cleaning composition comprises the following components in parts by weight:

[0034] (i) 0.12 parts of soapberry fruit extract;

[0035] (ii) 0.15 parts of camellia seed extract;

[0036] (iii) 1.2 parts of low molecular weight hyaluronic acid;

[0037] (iv) 0.001 part of sodium chloride;

[0038] (v) 0.001 parts of calcium chloride;

[0039] (vi) 0.001 part of magnesium sulfate;

[0040] (vii) 0.05 parts of dipotassium glycyrrhizate.

[0041] A second aspect of the present disclosure provides use of the cleaning composition in preparing a skin cleaning product.

[0042] Furthermore, the dosage form of the skin cleansing product includes but is not limited to spray, water, lotion, and cream.

[0043] A third aspect of the present disclosure provides a cleaning spray comprising 0.1 to 5 wt % of the cleaning composition. In some embodiments, the cleaning spray may comprise 0.1 wt %, 0.2 wt %, 0.4 wt %, 0.5 wt %, 0.8 wt %, 1.0 wt %, 1.5 wt %, 2.0 wt %, 2.5 wt %, 3.0 wt %, 3.5 wt %, 4.0 wt %, 4.5 wt %, 5.0 wt %, or the like of the cleaning composition.

[0044] In one embodiment of the present disclosure, the cleaning spray comprises the following components in percentage by mass:

[0045] 0.1-5% of the cleaning composition, 1-3% of butylene glycol, 0.5-2% of glycerin, 0.05-0.1% of methylpropanediol, 0.1-1% of p-hydroxyacetophenone, 0.05-2% of babassu seed oil glyceryl polyether-8 esters, 0.1-0.3% of caprylhydroxyvaleric acid, 0.01-0.5% of arginine, 0.001-0.01% of 1,2-hexanediol, 0.005-0.01% of fragrance, 0.01-0.03% of potassium sorbate, 0.1-0.3% of glyceryl caprylate, and the balance of water.

[0046] Compared with the prior art, the present disclosure has the following beneficial effects:

[0047] The cleaning composition provided by the present disclosure has the characteristics of gentle cleansing. It can not only effectively clean the oil and dirt on the skin surface, but also improve the accumulation of oil in the pores and unclog the pores. In addition, it can effectively protect the skin's sebum film, strengthen the barrier, and increase the skin's moisture content, so that the skin will not dry out after washing. It is very friendly to sensitive skin and brittle skin. DETAILED DESCRIPTION

[0048] The technical solutions of the present disclosure will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanations of the present disclosure and should not be construed as limiting the scope of protection of the present disclosure. All technologies implemented based on the above content of the present disclosure are included within the scope of protection intended by the present disclosure.

[0049] Unless otherwise specified, the raw materials and reagents used in the following examples are commercially available or can be prepared by known methods.

[0050] Soapberry fruit extract was purchased from Modern Biolande Biotechnology (Jiangsu) Co., Ltd.;

[0051] Camellia seed extract was purchased from Guangdong Jingcui Biotechnology Co., Ltd.;

[0052] Low molecular weight hyaluronic acid and high molecular weight hyaluronic acid were purchased from Shandong Runxin Biotechnology Co., Ltd. The molecular weight of low molecular weight hyaluronic acid ranged from 10 to 50 kDa, and the molecular weight of high molecular weight hyaluronic acid ranged from 200 to 500 kDa.

[0053] Sodium chloride, calcium chloride, magnesium sulfate, and dipotassium glycyrrhizate were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0054] Example 1

[0055] This embodiment provides a cleaning composition comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, 1.2 parts of low molecular weight hyaluronic acid, 0.001 parts of sodium chloride, 0.001 parts of calcium chloride, 0.001 parts of magnesium sulfate, and 0.05 parts of dipotassium glycyrrhizate.

[0056] Example 2

[0057] This embodiment provides a cleaning composition comprising the following components in parts by weight: 0.2 parts of soapberry fruit extract, 0.2 parts of camellia seed extract, 1.0 parts of low molecular weight hyaluronic acid, 0.02 parts of sodium chloride, 0.005 parts of calcium chloride, 0.01 parts of magnesium sulfate, and 0.01 parts of dipotassium glycyrrhizate.

[0058] Example 3

[0059] This embodiment provides a cleaning composition comprising the following components in parts by weight: 0.5 parts of soapberry fruit extract, 0.1 parts of camellia seed extract, 0.6 parts of low molecular weight hyaluronic acid, 0.005 parts of sodium chloride, 0.01 parts of calcium chloride, 0.005 parts of magnesium sulfate, and 0.1 parts of dipotassium glycyrrhizate.

[0060] Example 4

[0061] This embodiment provides a cleaning composition comprising the following components in parts by weight: 0.1 part of soapberry fruit extract, 0.5 part of camellia seed extract, 1.8 parts of low molecular weight hyaluronic acid, 0.01 part of sodium chloride, 0.001 part of calcium chloride, 0.003 part of magnesium sulfate, and 0.06 part of dipotassium glycyrrhizate.

[0062] Example 5

[0063] This embodiment provides a cleaning composition comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, 1.2 parts of low molecular weight hyaluronic acid, 0.001 parts of sodium chloride, and 0.05 parts of dipotassium glycyrrhizate.

[0064] Comparative Example 1

[0065] This comparative example provides a cleaning composition, comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract and 0.15 parts of camellia seed extract.

[0066] Comparative Example 2

[0067] This comparative example provides a cleaning composition, comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, and 1.2 parts of low-molecular-weight hyaluronic acid.

[0068] Comparative Example 3

[0069] This comparative example provides a cleaning composition comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, 0.001 parts of sodium chloride, 0.001 parts of calcium chloride, 0.001 parts of magnesium sulfate, and 0.05 parts of dipotassium glycyrrhizate.

[0070] Comparative Example 4

[0071] This comparative example provides a cleaning composition, comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, and 0.05 parts of dipotassium glycyrrhizate.

[0072] Comparative Example 5

[0073] This comparative example provides a cleaning composition comprising the following components in parts by weight: 0.12 parts of soapberry fruit extract, 0.15 parts of camellia seed extract, 1.2 parts of high molecular weight hyaluronic acid, 0.001 parts of sodium chloride, 0.001 parts of calcium chloride, 0.001 parts of magnesium sulfate, and 0.05 parts of dipotassium glycyrrhizate.

[0074] The specific formulas of the cleaning compositions in the above examples and comparative examples are shown in Table 1.

[0075] Table 1

[0076]

[0077] Application Examples 1-10

[0078] According to the ratio in Table 2, the cleaning compositions of Examples 1 to 5 and Comparative Examples 1 to 5 were further prepared into cleaning sprays, which were Application Examples 1 to 10, respectively. The specific preparation method is as follows:

[0079] 1. Add butylene glycol, glycerol, and methylpropylene glycol to deionized water and stir until completely dissolved;

[0080] 2. Then, add p-hydroxyacetophenone and babassu seed oil glyceryl ether-8 esters and stir until fully dissolved;

[0081] 3. Then, dissolve the camellia seed extract, soapberry extract and hyaluronic acid in a small amount of deionized water, add them to the above solution, and stir until uniform;

[0082] 4. Next, add dipotassium glycyrrhizate, caprylhydroxyvaleric acid, arginine, 1,2-hexanediol, and flavor and stir until completely dissolved.

[0083] 5. Finally, add sodium chloride, calcium chloride, and magnesium sulfate and stir until completely dissolved;

[0084] 6. After passing the inspection, filter and discharge the material.

[0085] Table 2

[0086] raw material effect parts by weight Cleaning composition - - Butanediol moisturizer 2 glycerin moisturizer 2 Methylpropanediol solvent 0.05 p-Hydroxyacetophenone antioxidants 0.15 Babassu Seed Oil Glycereth-8 Esters cleaning agents 0.3 Octanoylhydroxyvaleric acid preservative 0.2 Arginine pH adjusters 0.02 1,2-Hexanediol moisturizer 0.01 essence fragrances 0.005 Potassium sorbate preservative 0.02 Glyceryl Caprylate moisturizer 0.15 water solvent TO100

[0087] Note: The weight parts of the cleaning composition are the total weight parts of all components in the corresponding examples / comparative examples.

[0088] Experimental Example 1: Skin Porphyrin Area

[0089] Healthy people aged between 18 and 50 years old, regardless of gender (pregnant or lactating women are excluded); those with relatively strong facial oil secretion and a certain degree of acne; those without severe systemic diseases, immunodeficiency or autoimmune diseases, and the test site has not received skin treatment, cosmetic treatment, or other tests that may affect the results; those without active allergic diseases or highly sensitive constitutions; those who have not used hormonal drugs or immunosuppressants in the past month; and those whose test site has not participated in other clinical trials currently or in the past three months.

[0090] Sample Usage: Wash your face and spray the samples from Application Examples 1-10 onto your face for four consecutive weeks. Simultaneously, set up a blank control group using plain water. Volunteers were not allowed to use other skincare products during the test period.

[0091] Before and after use, the facial porphyrin area was measured using the facial image analysis system Visia CR. The results are shown in Table 3.

[0092] Table 3 (n=32)

[0093]

[0094] Note: P<0.001 and P<0.05 indicate that there is a significant difference in the rate of change in skin porphyrin area reduction compared with the blank control group.

[0095] Oil is the foundation for the growth of acne-causing bacteria. High levels of oil in the skin increase the risk of acne. Porphyrins are metabolic products of bacteria that live in hair follicles. The area of ​​porphyrins on the skin can reflect the skin's oil secretion and the accumulation of oil within the pores.

[0096] Please refer to Table 3. After the volunteers used the cleansing spray of Application Examples 1 to 5 for 4 weeks, the skin porphyrin area decreased significantly, with the change rate exceeding 40%. The P value of the change rate compared with the blank control group was <0.001, which was significantly different. In comparison, the skin porphyrin area of ​​the blank control group using clean water only decreased by 8.99%.

[0097] In Application Example 8, when the cleansing composition did not contain low molecular weight hyaluronic acid, the skin porphyrin area also showed a significant decrease after 4 weeks of use by volunteers, and the rate of change was compared with the blank control group with a P value <0.05, showing a significant difference. However, the magnitude of the decrease was much lower than that in Example 1, at only 25.51%. This is because low molecular weight hyaluronic acid can play a role in promoting penetration, allowing the cleansing ingredients to penetrate deeply into the pores, thereby more effectively exerting its role in cleaning and removing grease from the pores, improving the situation of grease accumulation in the pores of people with oily skin, thereby helping to unclog the pores and thus reducing the skin porphyrin area.

[0098] In Application Example 7, when the cleaning composition does not contain electrolytes, the area of ​​skin porphyrins decreased significantly after 4 weeks of use by volunteers, and the rate of change was compared with the blank control group with a P value <0.05, showing a significant difference. However, the decline was less than that in Example 1, at 34.50%. This is because the supplementation of electrolytes helps maintain the normal function of sebaceous gland cells, keeping oil secretion in a balanced state. At the same time, the supplementation of electrolytes helps maintain the acid-base balance on the skin surface, inhibits the growth of harmful microorganisms, and also helps maintain the integrity of the skin barrier function, thereby indirectly affecting oil secretion. Therefore, the supplementation of electrolytes also reduces the area of ​​skin porphyrins to a certain extent.

[0099] In Application Example 6, when the cleansing composition did not contain low molecular weight hyaluronic acid and electrolytes, the area of ​​skin porphyrins decreased significantly after four weeks of use in volunteers, with a rate of change compared to the blank control group (P value < 0.05), indicating a significant difference. However, the decrease in this group was minimal, at only 25.51%. This suggests that low molecular weight hyaluronic acid and electrolytes can synergistically reduce the area of ​​skin porphyrins.

[0100] In Application Example 9, when the cleansing composition contained only one electrolyte, dipotassium glycyrrhizate, the area of ​​skin porphyrins also showed a significant decrease after 4 weeks of use by the volunteers, with a change rate of 36.17%. The change rate was significantly different from that of the blank control group with a P value of <0.05. However, the change rate was still much lower than the 47.62% in Application Example 1. This shows that the effect of supplementing with dipotassium glycyrrhizate alone is not good, while supplementing with sodium chloride, calcium chloride, magnesium sulfate, and dipotassium glycyrrhizate at the same time can better repair the skin barrier and maintain the integrity of the skin barrier function, thereby indirectly affecting oil secretion.

[0101] In Application Example 10, when high molecular weight hyaluronic acid was used in the cleansing composition, the area of ​​porphyrins on the skin of volunteers also showed a significant decrease after 4 weeks of use, with a change rate of 35.20%. The change rate was significantly different from the blank control group with a P value of <0.05. However, this change rate was still much lower than the 47.62% in Application Example 1. This is because, although high molecular weight hyaluronic acid has good hydration and moisturizing effects, its molecular chain is relatively large and cannot act as a penetration enhancer. It cannot help cleansing ingredients such as saponin molecules enter the pores to clean the oil in the pores, and thus cannot improve the accumulation of oil in the pores.

[0102] Experimental Example 2: Skin Moisture Content

[0103] Healthy people aged between 18 and 50 years old, regardless of gender (pregnant or lactating women are excluded); those with relatively strong facial oil secretion and a certain degree of acne; those without severe systemic diseases, immunodeficiency or autoimmune diseases, and the test site has not received skin treatment, cosmetic treatment, or other tests that may affect the results; those without active allergic diseases or highly sensitive constitutions; those who have not used hormonal drugs or immunosuppressants in the past month; and those whose test site has not participated in other clinical trials currently or in the past three months.

[0104] Sample Usage: Wash your face and spray the samples from Application Examples 1-10 onto your face for four consecutive weeks. Simultaneously, set up a blank control group using plain water. Volunteers were not allowed to use other skincare products during the test period.

[0105] Before and after use, the transepidermal water loss rate of the face was tested using a TEWL transepidermal water loss meter, and the water content of the facial stratum corneum was tested using a Corneometer skin moisture tester. The results are shown in Table 4.

[0106] Table 4 (n=30)

[0107]

[0108] Note: P<0.001 and P<0.05 indicate that compared with the blank control group, the change rate of transepidermal water loss / the change rate of stratum corneum water content have significant differences; P>0.05 indicates that compared with the blank control group, the change rate of transepidermal water loss / the change rate of stratum corneum water content have no significant differences.

[0109] Please refer to Table 4. After the volunteers in the blank control group used clean water for 4 weeks, there was no significant change in the transepidermal water loss rate and the stratum corneum water content. In contrast, after the volunteers used the cleaning spray of Application Examples 1 to 5 for 4 weeks, the transepidermal water loss rate decreased significantly, with a decrease of more than 20%, and the change rate was compared with the blank control group with a P value of <0.001, which was significantly different; at the same time, the stratum corneum water content increased significantly, with an increase of about 60% or more, and the change rate was compared with the blank control group with a P value of <0.001, which was significantly different. This shows that the cleaning spray of Application Examples 1 to 5 of the present disclosure is beneficial to reducing the transepidermal water loss rate and increasing the water content of the stratum corneum of the skin, thereby improving the skin barrier function and preventing the skin from drying out after washing.

[0110] Compared to Application Example 1, the decrease in transepidermal water loss in Application Example 5 was smaller, and the increase in stratum corneum water content was also smaller. This is because the electrolytes in the cleansing combination in Application Example 5 only contained sodium chloride and dipotassium glycyrrhizate, but not calcium chloride and magnesium sulfate. Since magnesium sulfate has a very significant effect in preventing skin water loss and improving stratum corneum hydration, and can synergistically promote skin barrier repair after barrier damage with calcium chloride, Application Example 1 achieved significantly higher transepidermal water loss and stratum corneum water content than Application Example 5.

[0111] In Application Example 8, when the cleansing composition did not contain low-molecular-weight hyaluronic acid, volunteers experienced a modest decrease in transepidermal water loss (TEWL) and a modest increase in stratum corneum water content after four weeks of use. The rate of change was statistically significant (P value < 0.05) compared to the blank control group. However, the decrease in TEL in Application Example 8 was much lower than in Application Example 1, at only 8.5%. The increase in stratum corneum water content was also much lower than in Application Example 1, at only 23.0%.

[0112] Similarly, in Application Example 7, when the cleansing composition did not contain electrolytes, after 4 weeks of use by volunteers, the transepidermal water loss rate decreased by 17.9%, and the rate of change compared with the blank control group had a P value of <0.05, which was significantly different; the stratum corneum water content increased by 41.8%, and the rate of change compared with the blank control group had a P value of <0.001, which was significantly different; however, the changes in the transepidermal water loss rate and stratum corneum water content in Application Example 7 were also much lower than those in Application Example 1.

[0113] In Application Example 6, when the cleansing composition did not contain low molecular weight hyaluronic acid and electrolytes, after four weeks of use, the volunteers showed the lowest reduction in transepidermal water loss and the lowest increase in stratum corneum water content, at only 5.1% and 11.6%, respectively. Furthermore, the rate of change was not significantly different from that of the blank control group, with a P value greater than 0.05.

[0114] In Application Example 9, when the cleansing composition contained only dipotassium glycyrrhizate as one electrolyte, after four weeks of use, volunteers experienced a 18.3% decrease in transepidermal water loss (TEWL) and a significant difference (P value < 0.05) compared to the blank control group. The stratum corneum water content also increased by 53.8%, with a significant difference (P value < 0.001) compared to the blank control group. However, compared to Application Example 1, the decrease in TEWL and the increase in TEWL in Application Example 9 were significantly lower than those in Application Example 1. This suggests that the type of electrolyte in the cleansing composition significantly influences TEWL and TEWL. When only dipotassium glycyrrhizate was included in the cleansing composition, the improvement in TEWL and TEWL was ineffective. However, the simultaneous addition of sodium chloride, calcium chloride, magnesium sulfate, and dipotassium glycyrrhizate effectively repaired the skin barrier and maintained the integrity of the skin barrier function, thereby reducing TEWL and increasing TEWL.

[0115] In Application Example 10, when high-molecular-weight hyaluronic acid was used in the cleansing composition, after four weeks of use, the transepidermal water loss rate decreased by 31.4%, with a significant difference (P value < 0.001) compared to the blank control group. The stratum corneum water content increased by 72.2%, with a significant difference (P value < 0.001) compared to the blank control group. The reduction in transepidermal water loss rate and the increase in stratum corneum water content in Application Example 10 were both similar to those in Application Example 1. This demonstrates that high-molecular-weight hyaluronic acid has similar effects on increasing skin hydration as low-molecular-weight hyaluronic acid.

[0116] These results demonstrate that the low-molecular-weight hyaluronic acid and electrolytes in the cleansing composition have a significant impact on transepidermal water loss (TEWL) and stratum corneum water content, synergistically reducing TEL and increasing stratum corneum water content. This is because low-molecular-weight hyaluronic acid penetrates deeply into the stratum corneum, where its powerful water-absorbing and water-locking abilities help maintain sufficient moisture in the stratum corneum, plumping up skin cells and strengthening the skin's barrier function. Sodium chloride, calcium chloride, and magnesium sulfate, on the other hand, replenish electrolytes lost during cleansing, maintaining electrolyte balance and regulating water distribution inside and outside the cells, keeping skin cells plump, preventing dryness and dehydration, and maintaining skin hydration and elasticity. Furthermore, electrolytes help maintain the integrity and tightness of the stratum corneum, enhancing the skin's barrier function. Therefore, low-molecular-weight hyaluronic acid and electrolytes create a synergistic effect, better protecting the skin's sebum membrane, strengthening the barrier, and increasing skin hydration, preventing dryness after washing.

[0117] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present disclosure and are not limiting. Although the present disclosure has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present disclosure may be modified or replaced by equivalents without departing from the purpose and scope of the technical solutions of the present disclosure, and all of these should be included in the scope of the claims of the present disclosure.

Claims

1. A cleaning composition, characterized in that The cleaning composition comprises the following components in parts by weight: (i) 0.1-0.5 parts of soapberry fruit extract; (ii) 0.1-0.5 parts of camellia seed extract; (iii) 0.5-2 parts of low molecular weight hyaluronic acid; (iv) 0.01 to 0.2 parts of electrolyte.

2. A cleaning composition according to claim 1, characterized in that The molecular weight of the low molecular weight hyaluronic acid is 10 to 50 kDa.

3. A cleaning composition according to claim 1, characterized in that The electrolyte includes at least sodium chloride and dipotassium glycyrrhizate.

4. A cleaning composition according to claim 3, characterized in that The electrolyte further includes at least one of calcium chloride and magnesium sulfate.

5. A cleaning composition according to claim 1, characterized in that The cleaning composition comprises the following components in parts by weight: (i) 0.1-0.2 parts of soapberry fruit extract; (ii) 0.1-0.2 parts of camellia seed extract; (iii) 1-2 parts of low molecular weight hyaluronic acid; (iv) 0.02 to 0.1 parts of electrolyte.

6. A cleaning composition according to claim 1, characterized in that The cleaning composition comprises the following components in parts by weight: (i) 0.12 parts of soapberry fruit extract; (ii) 0.15 parts of camellia seed extract; (iii) 1.2 parts of low molecular weight hyaluronic acid; (iv) 0.001 part of sodium chloride; (v) 0.001 parts of calcium chloride; (vi) 0.001 part of magnesium sulfate; (vii) 0.05 parts of dipotassium glycyrrhizate.

7. Use of the cleaning composition according to any one of claims 1 to 6 in the preparation of skin cleaning products.

8. The use according to claim 7, characterized in that The dosage forms of the skin cleaning product include spray, water, emulsion and cream.

9. A cleaning spray, characterized in that: The cleaning spray contains 0.1 to 5 wt % of the cleaning composition according to any one of claims 1 to 6.

10. A cleaning spray according to claim 9, characterized in that: The cleaning spray comprises the following components by mass percentage: 0.1-5% of the cleaning composition, 1-3% of butylene glycol, 0.5-2% of glycerin, 0.05-0.1% of methylpropanediol, 0.1-1% of p-hydroxyacetophenone, 0.05-2% of babassu seed oil glyceryl polyether-8 esters, 0.1-0.3% of caprylhydroxyvaleric acid, 0.01-0.5% of arginine, 0.001-0.01% of 1,2-hexanediol, 0.005-0.01% of fragrance, 0.01-0.03% of potassium sorbate, 0.1-0.3% of glyceryl caprylate, and the balance of water.

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