Whitening, anti-wrinkle, firming and soothing multi-effect composition and application thereof

Abstract

The invention discloses a whitening, anti-wrinkle, firming and soothing multi-effect composition, which is prepared from the following raw material components: nicotinamide, hydroxypropyl tetrahydropyrantriol, p-hydroxyacetophenone, glycerol, 1, 2-pentanediol, 1, 2-hexanediol, a barley extract composition, panthenol, a radix gentianae extract composition, an oat kernel extract composition and the balance of water. The barley extract, the radix gentianae extract and the oat kernel extract are added into the whitening, anti-wrinkle, firming and soothing multi-effect composition, so that melanosome can be inhibited from being transferred to the skin surface, DNA damage caused by UV is repaired, photoimmunosuppression is intervened, elastase and hyaluronidase are inhibited, and the whitening, anti-wrinkle, firming and soothing multi-effect composition has the advantages that the whitening, anti-wrinkle, firming and soothing functions are realized; the face cream prepared from the multi-effect composition for whitening, resisting wrinkles, tightening and relieving has the effects of whitening, resisting wrinkles, tightening and relieving.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to a whitening, anti-wrinkle, firming and soothing multi-effect composition and application thereof. Background Art

[0002] New cosmetics regulations define product efficacy differently. Anti-freckle and whitening products refer to products that "help reduce or slow down skin pigmentation, achieving a whitening and brightening effect; achieving a whitening and brightening effect through physical concealing." Anti-wrinkle products refer to products that "help slow down the development of wrinkles or make them less noticeable." Firming products refer to products that "help maintain skin firmness and elasticity." Soothing products refer to products that "help improve skin irritation and other conditions." Many factors influence skin condition. External factors, such as light exposure and pre-existing genetic and endocrine disorders, can cause DNA damage, increased ROS production, activation of the NF-κB inflammatory pathway, slowed keratinocyte growth, disrupted elastic fibers, and decreased collagen production, leading to skin aging, sagging, wrinkles, dilated capillaries, and uneven skin tone.

[0003] Currently, there are many methods for skin whitening, anti-wrinkle, and firming. In pursuit of significant results, some consumers resort to "drastic" treatments or non-compliant cosmetics to achieve immediate whitening, firming, and anti-wrinkle effects. However, these methods can disrupt skin metabolism, leading to sagging, darkening, allergies, and even dependence, resulting in dark spots. Given the increasing demand for all-in-one whitening, anti-wrinkle, and firming products, and the increasing consumer preference for "green, safe, and effective" whitening and other functional cosmetics among those with sensitive skin, there is an urgent need to develop a cosmetic combination with all-in-one whitening, anti-wrinkle, firming, and soothing effects for widespread application. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a whitening, anti-wrinkle, firming and soothing multi-effect composition and its application.

[0005] A whitening, anti-wrinkle, firming and soothing multi-effect composition comprises the following raw materials, calculated by mass percentage: 1-20% niacinamide, 1-40% hydroxypropyl tetrahydropyrantriol, 0.1-1% p-hydroxyacetophenone, 1-5% glycerol, 0.1-1% 1,2-pentanediol, 0.1-1% 1,2-hexanediol, 1-15% barley extract composition, 1-5% panthenol, 0.02-2% gentian root extract composition, 0.02-2% oat kernel extract composition, and the balance water.

[0006] Furthermore, the barley extract composition comprises, by weight percentage, 45-55% 1,3-propylene glycol, 1.8-2.2% barley extract, and the balance water;

[0007] Furthermore, the raw materials of the gentian root extract composition include 4-6% gentian root extract, 45-55% butylene glycol and the balance water, calculated by mass percentage;

[0008] Furthermore, the oat kernel extract composition comprises, by weight percentage, 4-6% oat kernel extract, 20-30% butanediol, 17-23% 1,2-pentanediol, and the balance water;

[0009] Furthermore, the preparation method of the whitening, anti-wrinkle, firming and soothing multi-effect composition comprises the following steps:

[0010] (1) Pour water into a production tank, stir and heat to 80-85°C, keep warm for 20-40 minutes, cool to 55-65°C, add niacinamide and hydroxypropyl tetrahydropyrantriol, mix, and cool to 40-50°C to prepare component A;

[0011] (2) mixing p-hydroxyacetophenone, glycerol, 1,2-pentanediol and 1,2-hexanediol, and adding the mixture to component A to prepare component B;

[0012] (3) The barley extract composition, panthenol, gentian root extract composition, and oat kernel extract composition are added to component B and mixed to prepare a whitening, anti-wrinkle, firming, and soothing multi-effect composition.

[0013] Furthermore, the barley extract is a barley (HORDEUM VULGARE) extract or a barley fermentation extract; the gentian root extract is a gentian (GENTIANA SCABRA) root extract; and the oat kernel extract is an oat (AVENASATIVA) kernel extract.

[0014] Furthermore, the raw materials include the following components, calculated by mass percentage: 10% niacinamide, 20% hydroxypropyl tetrahydropyrantriol, 0.5% p-hydroxyacetophenone, 3% glycerol, 0.5% 1,2-pentanediol, 0.5% 1,2-hexanediol, 7% barley extract composition, 3% panthenol, 1% gentian root extract composition, 1% oat kernel extract composition and the balance water.

[0015] Furthermore, the whitening, anti-wrinkle, firming and soothing multi-effect composition is used in the preparation of skin care products with skin whitening, firming, anti-wrinkle and soothing effects.

[0016] Furthermore, the skin care product is one of lotion, moisturizer, and face cream.

[0017] Furthermore, the cream comprises, by mass percentage, 1-10% glycerin, 0.01-0.1% sodium polyacrylate, 0.01-1% xanthan gum, 0.01-1% hydrogenated lecithin, 0.01-0.1% disodium EDTA, 0.04-4% cetearyl olivate, 0.04-4% sorbitan olivate, 1-6% behenyl alcohol, 1-10% caprylic / capric triglyceride, 1-5% dimethicone, 0.02-2% tocopheryl acetate, 0.1-1% parahydroxyacetophenone, 1-5% 1,3-propylene glycol, 0.02-2% 1,2-pentanediol, 0.02-2% 1,2-hexanediol, 1-30% whitening, anti-wrinkle, firming and soothing multi-effect composition, and the balance water;

[0018] Material A is prepared by mixing water, glycerin, sodium polyacrylate, xanthan gum, hydrogenated lecithin, and disodium EDTA;

[0019] Material B is prepared by mixing cetearyl olivate, sorbitan olivate, behenyl alcohol, caprylic / capric triglyceride, dimethicone, and tocopheryl acetate;

[0020] Material C was prepared by mixing p-hydroxyacetophenone, 1,3-propylene glycol, 1,2-pentanediol and 1,2-hexanediol.

[0021] Furthermore, the preparation method of the facial cream comprises the following steps:

[0022] S1: Add material A into the production tank, homogenize at 2000-3000r / min for 8-20min, stir, and the temperature of the production tank is 83-85℃;

[0023] S2: Add material B to the oil phase pot and stir. The oil phase pot temperature is 83-85℃;

[0024] S3: Add material B obtained in step S2 into the production tank, homogenize at 2000-3000 r / min under vacuum for 10-20 min, keep at 83-85°C for 15-25 min, and start cooling. When the temperature drops to 42-45°C, material D is obtained;

[0025] S4: Add material C and the whitening, anti-wrinkle, firming and soothing multi-effect composition to material D and mix to obtain a finished product.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The whitening, anti-wrinkle, firming, and soothing multi-effect composition of the present invention comprises ingredients such as niacinamide, hydroxypropyl tetrahydropyrantriol, a barley extract composition, panthenol, a gentian root extract composition, and an oat kernel extract composition. The composition achieves whitening, anti-wrinkle, firming, and soothing effects by inhibiting the transfer of melanosomes to the skin surface, repairing UV-induced DNA damage, intervening in photoimmunosuppression, inhibiting elastase, and inhibiting hyaluronidase. It mitigates skin darkening, sagging, and wrinkles caused by factors such as aging and sun exposure. The overall formula is very mild and non-irritating, expanding the composition's scope of application.

[0028] The rational proportion of the raw materials of the present invention improves the whitening, anti-wrinkle, firming and soothing effects of the composition and improves the stability of the finished product. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 Experimental Example 3: Facial Image Comparison Analysis DETAILED DESCRIPTION

[0030] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0031] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0032] Unless otherwise specified, the materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources.

[0033] Example 1 Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition

[0034] (1) Weigh the raw materials:

[0035] Calculated by mass percentage, 10% niacinamide, 20% hydroxypropyl tetrahydropyrantriol, 0.5% p-hydroxyacetophenone, 3% glycerol, 0.5% 1,2-pentanediol, 0.5% 1,2-hexanediol, 7% barley extract composition, 3% D-panthenol, 1% gentian root extract composition, 1% oat kernel extract composition and the balance water were weighed.

[0036] The barley extract composition is composed of 50% 1,3-propylene glycol, 2% hordeum vulgare extract and the balance water, calculated by mass percentage.

[0037] The gentian root extract composition is weighed by weight: 5% gentian root extract, 50% butylene glycol and the balance water;

[0038] The oat kernel extract composition is calculated by weight percentage, and 5% of oat kernel extract (AVENA SATIVA), 25% of butylene glycol, 20% of 1,2-pentanediol and the balance of water are weighed.

[0039] (3) Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition:

[0040] S1: Pour water into a production tank, stir and heat to 85°C, keep warm for 30 minutes, cool to 60°C, add niacinamide and hydroxypropyl tetrahydropyrantriol, mix, and cool to 45°C to prepare component A;

[0041] S2: mixing p-hydroxyacetophenone, glycerol, 1,2-pentanediol and 1,2-hexanediol, and adding the mixture to component A to prepare component B;

[0042] S3: adding the barley extract composition, D-panthenol, the gentian root extract composition, and the oat kernel extract composition to component B, stirring evenly, and filtering the material through a 400-mesh filter.

[0043] Example 2 Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition

[0044] (1) Weigh the raw materials:

[0045] Calculated by mass percentage, 1% niacinamide, 1% hydroxypropyl tetrahydropyrantriol, 0.1% p-hydroxyacetophenone, 1% glycerol, 0.1% 1,2-pentanediol, 0.1% 1,2-hexanediol, 1% barley extract composition, 1% D-panthenol, 0.02% gentian root extract composition, 0.02% oat kernel extract composition and the balance water were weighed.

[0046] The barley extract composition comprises, by weight percentage, 45% 1,3-propylene glycol, 1.8% hordeum vulgare extract and the remainder water;

[0047] The gentian root extract composition comprises, by weight percentage, 4% gentian root extract, 45% butylene glycol and the balance water;

[0048] The oat kernel extract composition is composed of 4% of oat kernel extract (AVENA SATIVA), 20% of butylene glycol, 17% of 1,2-pentanediol and the balance of water in terms of mass percentage.

[0049] (3) Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition:

[0050] S1: Pour water into a production tank, stir and heat to 85°C, keep warm for 30 minutes, cool to 60°C, add niacinamide and hydroxypropyl tetrahydropyrantriol, mix, and cool to 45°C to prepare component A;

[0051] S2: mixing p-hydroxyacetophenone, glycerol, 1,2-pentanediol and 1,2-hexanediol, and adding the mixture to component A to prepare component B;

[0052] S3: adding the barley extract composition, D-panthenol, the gentian root extract composition, and the oat kernel extract composition to component B, stirring evenly, and filtering the material through a 400-mesh filter.

[0053] Example 3 Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition

[0054] (1) Weigh the raw materials:

[0055] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 15% barley extract composition, 5% D-panthenol, 2% gentian root extract composition, 2% oat kernel extract composition and the balance water were weighed.

[0056] The barley extract composition comprises, by weight percentage, 55% 1,3-propylene glycol, 2.2% hordeum vulgare extract and the balance water;

[0057] The gentian root extract composition comprises, by weight percentage, 6% of gentian root extract, 55% of butylene glycol and the balance of water;

[0058] The oat kernel extract composition is composed of 6% of oat kernel extract (AVENA SATIVA), 30% of butylene glycol, 23% of 1,2-pentanediol and the balance of water in terms of mass percentage.

[0059] (3) Preparation method of whitening, anti-wrinkle, firming and soothing multi-effect composition:

[0060] S1: Pour water into a production tank, stir and heat to 85°C, keep warm for 30 minutes, cool to 60°C, add niacinamide and hydroxypropyl tetrahydropyrantriol, mix, and cool to 45°C to prepare component A;

[0061] S2: mixing p-hydroxyacetophenone, glycerol, 1,2-pentanediol and 1,2-hexanediol, and adding the mixture to component A to prepare component B;

[0062] S3: adding the barley extract composition, D-panthenol, the gentian root extract composition, and the oat kernel extract composition to component B, stirring evenly, and filtering the material through a 400-mesh filter.

[0063] Comparative Example 1

[0064] On the basis of Example 1, the gentiana scabra root extract was replaced with the sedum rosea root extract and the centella asiatica extract. The specific scheme is:

[0065] Calculated by mass percentage, 10% niacinamide, 20% hydroxypropyl tetrahydropyrantriol, 0.5% p-hydroxyacetophenone, 3% glycerol, 0.5% 1,2-pentanediol, 0.5% 1,2-hexanediol, 7% barley extract composition, 3% D-panthenol, 1% Centella asiatica and Rhodiola rosea composition, 1% oat kernel extract composition and the balance water were weighed.

[0066] The barley extract composition is composed of 50% 1,3-propylene glycol, 2% hordeum vulgare extract and the balance water, calculated by mass percentage.

[0067] The gentian root extract composition is prepared by weighing, by mass percentage, 3% of Sedum rosea root extract, 3% of Centella asiatica extract, 50% of butylene glycol and the balance of water;

[0068] The oat kernel extract composition is calculated by weight percentage, and 5% of oat kernel extract (AVENA SATIVA), 25% of butylene glycol, 20% of 1,2-pentanediol and the balance of water are weighed.

[0069] The remaining steps are the same as those in Example 1.

[0070] Comparative Example 2

[0071] The raw material ratio was adjusted on the basis of Example 1, and the specific solution was as follows:

[0072] Calculated by mass percentage, 15% niacinamide, 20% hydroxypropyl tetrahydropyrantriol, 0.5% p-hydroxyacetophenone, 3% glycerol, 0.5% 1,2-pentanediol, 0.5% 1,2-hexanediol, 3% barley extract composition, 7% D-panthenol, 4% gentian root extract composition, 3% oat kernel extract composition and the balance water were weighed.

[0073] The barley extract composition is composed of 50% 1,3-propylene glycol, 2% hordeum vulgare extract and the balance water, calculated by mass percentage.

[0074] The gentian root extract composition is weighed by weight: 5% gentian root extract, 50% butylene glycol and the balance water;

[0075] The oat kernel extract composition is calculated by weight percentage, and 5% of oat kernel extract (AVENA SATIVA), 25% of butylene glycol, 20% of 1,2-pentanediol and the balance of water are weighed.

[0076] The remaining steps are the same as in Example 1.

[0077] Example 4 Preparation method of a facial cream containing a whitening, anti-wrinkle, firming and soothing multi-effect composition

[0078] (1) Weighing the sample:

[0079] Calculated by weight percentage, weigh 5% glycerin, 0.05% sodium polyacrylate, 0.05% xanthan gum, 0.5% hydrogenated lecithin, 0.05% disodium EDTA, 2% cetearyl olivate, 2% sorbitan olivate, 3% behenyl alcohol, 5% caprylic / capric triglyceride, 3% dimethicone, 1% tocopheryl acetate, 0.5% parahydroxyacetophenone, 3% 1,3-propylene glycol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 15% whitening, anti-wrinkle, firming and soothing multi-effect composition and the balance water.

[0080] Material A is prepared by mixing water, glycerin, sodium polyacrylate, xanthan gum, hydrogenated lecithin, and disodium EDTA;

[0081] Material B is prepared by mixing cetearyl olivate, sorbitan olivate, behenyl alcohol, caprylic / capric triglyceride, dimethicone, and tocopheryl acetate;

[0082] Material C was prepared by mixing p-hydroxyacetophenone, 1,3-propylene glycol, 1,2-pentanediol and 1,2-hexanediol.

[0083] (2) Preparation method of facial cream:

[0084] S1: Add material A into the production tank, homogenize at 2500r / min for 15min, stir, and the temperature of the production tank is 84℃;

[0085] S2: Add material B to the oil phase pot and stir. The oil phase pot temperature is 84°C.

[0086] S3: Add material B obtained in step S2 into the production tank, homogenize at 2500 r / min under vacuum for 15 minutes, keep the temperature at 84°C for 20 minutes, and start cooling. When the temperature drops to 43°C, material D is obtained;

[0087] S4: Add material C and the whitening, anti-wrinkle, firming and soothing multi-effect composition to material D and mix to obtain a finished product.

[0088] The whitening, anti-wrinkle, firming and soothing multi-effect compositions prepared in Examples 1-3 and Comparative Examples 1-2 were used to prepare facial creams according to the method of Example 4.

[0089] Test Example 1:

[0090] The whitening, anti-wrinkle, firming and soothing multi-effect composition of Example 1 was used to prepare a facial cream according to Example 4, and subjected to a freckle and whitening efficacy test according to Chapter 8, Method 1 of the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0091] The subjects were 25 women and 5 men, and the back was tested. First, the MED (minimal erythema dose) for each subject's test site was determined. Then, test areas were selected within the test site and irradiated once daily for four consecutive days using a solar simulator at a dose of 0.75 times the MED at the same irradiation point. This established a melanin model.

[0092] The test substance and positive control substance (7% ascorbic acid) were applied to the test site twice a day, with an interval of at least 4 hours between the two applications and a sample area of ​​6 cm 2 , the coating amount is 2.00±0.05mg / cm 2 The interval between each test area should be no less than 1.0 cm.

[0093] Apply the test substance continuously for 4 weeks. Perform visual assessment and instrumental testing of skin color 1 week, 2 weeks, 3 weeks, and 4 weeks after application, and record the results.

[0094] The measurement indicators are: MI (Melanin Index): This parameter characterizes the melanin content in the skin by measuring the absorption of specific wavelengths of light by the skin surface. A lower MI value indicates a lower melanin content, and vice versa. MI values ​​are measured using skin melanin and hemoglobin test probes.

[0095] ITA° (Individual Type Angle): A parameter that characterizes human skin color, measured using a skin colorimeter or reflectance spectrophotometer in the L*a*b* color space. A larger ITA° value indicates lighter skin, and vice versa. ITA° = {arctan(L*-50) / b*}180 / π.

[0096] The average results of ITA° and MI of the cream prepared in Example 3 and the positive and negative control groups are shown in Table 1:

[0097] Table 1

[0098]

[0099] The test results show that the facial cream containing the whitening, anti-wrinkle, firming and soothing multi-effect composition prepared by the present invention has the effects of removing spots and whitening.

[0100] Test Example 2:

[0101] Elastase is mainly synthesized and secreted by fibroblasts. It is a highly selective and specific proteolytic enzyme that catalyzes the hydrolysis of carboxyl-containing polypeptide bonds of many amino acids such as glycine, leucine, alanine, and valine. It can decompose elastin in connective tissue protein and lead to skin aging.

[0102] Referring to QTC-C-LAB-TOP-056, "In Vitro Test Method for Anti-Wrinkle and Firming Efficacy of Cosmetics (Elastase Inhibition Method)," the test concentration was 75 mg / mL, the positive control group consisted of a quercetin solution (200 μg / mL), and the negative control group consisted of water. The whitening, anti-wrinkle, firming, and soothing multi-effect compositions prepared in Examples 1-3 and Comparative Examples 1-2, and the cream prepared in Example 4, were tested for their elastase inhibition rates. The experimental results are shown in Table 2:

[0103] Table 2

[0104]

[0105]

[0106] The experimental results demonstrate that the whitening, anti-wrinkle, firming, and soothing multi-benefit composition of the present invention exhibits a significant inhibitory effect on elastase activity. Compared to the experimental results of Comparative Example 1, the rational proportioning of the components in the present invention further enhances the inhibitory effect of the finished product on elastase activity. The experimental results of Comparative Example 2 demonstrate that the rational use of raw materials can enhance the inhibitory effect of the finished product on elastase activity.

[0107] Test Example 3

[0108] The whitening, anti-wrinkle, firming and soothing multi-effect composition of Example 3 was prepared with reference to the cream prepared in Example 4, and the results were as follows: ALS-SOP-LT-032 "Human Anti-Wrinkle Efficacy Test Operation Specification", ALS-SOP-LT-033 "Human Firming Efficacy Test Operation Specification", ALS-SOP-LT-038 "Human Glossiness Test Operation Specification", ALS-SOP-IE-005 "Facial Image Analyzer VISIA-CR Standard Operating Procedure", ALS-SOP-IE-037 "Fiji Software Analysis of Roughness", The test was conducted in accordance with the "Standard Operating Procedure for Cosmetic Efficacy", ALS-SOP-LT-037 "Operational Specification for Consumer Use Testing of Cosmetics Efficacy", and T / CAB0152-2022 "Test Methods for Seven Efficacy of Cosmetics: Anti-wrinkle, Firming, Moisturizing, Oil Control, Repairing, Nourishing, and Soothing". Photos were taken using VISIA-CR, skin gloss was measured using a Glossymeter GL200, and skin elasticity R2 value and skin firmness F4 value were measured using a Cutometer.

[0109] The subjects were healthy men and women aged 35-60 years with prominent nasolabial folds, no skin diseases, and no previous cosmetic facial treatments within the past month. A total of 30 participants (29 women and 1 man, with an average age of 51.60 years) participated in the trial, with testing periods of 14 and 28 days.

[0110] See also Figure 1 Based on the results of instrument testing and image analysis, the 30 Asian subjects who completed the test had a significant improvement of 12.05% in the area of ​​nasolabial folds, 8.21% in the R2 value of skin elasticity, and 16.69% in skin glossiness after using the cream prepared by the present invention for 14 days; and a significant improvement of 19.34% in the area of ​​nasolabial folds, 22.57% in the R2 value of skin elasticity, 21.73% in the F4 value of skin firmness, and 32.51% in skin glossiness after using the cream prepared by the present invention for 28 days; this indicates that the cream prepared by the present invention has anti-wrinkle and firming effects.

[0111] Test Example 4

[0112] The whitening, anti-wrinkle, firming and soothing multi-effect composition of Example 3 was used to prepare the facial cream with reference to Example 4, and a human skin patch test was performed in accordance with the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0113] Subjects: A total of 30 subjects, including 8 males and 22 females, aged 19 to 59 years, with an average age of 37.60±12.20, met the volunteer inclusion criteria.

[0114] Patch test method: Select qualified patch test equipment and use the closed patch test method. Place approximately 0.020g to 0.025g of the test substance in the patch test device. Apply several strips of hypoallergenic tape to the subject's back to reinforce the patch test device. Remove the test substance after 24 hours. Observe the skin reaction 0.5, 24, and 48 hours after removal. Record the results according to the skin reaction grading standards in the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0115] The experimental results are shown in Table 3:

[0116] Table 3

[0117]

[0118] The test results show that the facial cream prepared by the present invention has no adverse reaction on the skin.

[0119] In order to further clarify the specific effects of each substance in the skin anti-wrinkle and firming effect of the present invention, the applicant further carried out the following sample preparation and testing:

[0120] Comparative Example 3

[0121] Whitening, anti-wrinkle, firming and soothing multi-effect composition

[0122] The same as Example 3, except for the formula, which is as follows:

[0123] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 15% barley extract composition, 5% D-panthenol, 4% gentian root extract composition and the balance water were weighed.

[0124] Comparative Example 4

[0125] The same as Example 3, except for the formula, which is as follows:

[0126] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 15% barley extract composition, 5% D-panthenol, 4% oat kernel extract composition and the balance water were weighed.

[0127] Comparative Example 5

[0128] The same as Example 3, except for the formula, which is as follows:

[0129] Calculate the mixture by mass: 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 15% barley extract composition, 5% D-panthenol, and the balance water.

[0130] Creams were prepared using the method of Example 4 for Example 3 and Comparative Examples 3 to 5, and the elastase inhibition rate test was performed again using the same test method as in Test Example 2.

[0131] The test results refer to Table 4;

[0132] Table 4

[0133] name Elastase inhibition rate (%) Example 3 35.21 Comparative Example 3 29.69 Comparative Example 4 31.07 Comparative Example 5 27.53 Negative control group 2.99 Positive control group 92.11

[0134] Result analysis:

[0135] 1. As shown in Example 3 and Comparative Example 5, the oat kernel extract composition and the gentian root extract composition of the present invention can improve the elastase inhibition ability of the basic component;

[0136] In practical applications, the oat kernel extract and gentian root extract compositions are added to the formula of the present invention primarily for soothing effects, thereby suppressing the irritation of the whitening and anti-aging ingredients. Experiments conducted by the present invention have shown that either the oat kernel extract or the gentian root extract not only has a soothing effect (details of which can be seen in subsequent experimental test results), but also slightly enhances the anti-wrinkle and firming effects of the barley extract and hydroxypropyl tetrahydropyrantriol compositions. When used in combination, the anti-wrinkle and firming effects are even more pronounced.

[0137] 2. As can be seen from Example 3 and Comparative Example 5, Comparative Example 3 and Comparative Example 5, and Comparative Example 4 and Comparative Example 5, when the oat kernel extract composition and the gentian root extract group are present simultaneously, their ability to improve the inhibitory ability of the base component against elastase is significant, indicating that the two have a significant synergistic effect on improving the inhibitory ability of niacinamide, hydroxypropyltetrahydropyrantriol, and barley extract composition against elastase.

[0138] In order to verify the skin soothing effect of the present invention, the applicant further carried out the following sample preparation and testing:

[0139] Example 5

[0140] Whitening, anti-wrinkle, firming and soothing multi-effect composition

[0141] The same as Example 3, except for the formula, which is as follows:

[0142] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 1% barley extract composition, 5% D-panthenol, 1% gentian root extract composition, 1% oat kernel extract composition and the balance water were weighed.

[0143] Example 6

[0144] Whitening, anti-wrinkle, firming and soothing multi-effect composition

[0145] The same as Example 3, except for the formula, which is as follows:

[0146] Calculate the mixture by mass: 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 2% barley extract composition, 5% D-panthenol, 2% gentian root extract composition, 2% oat kernel extract composition, and the balance water.

[0147] Comparative Example 6

[0148] The same as Example 5, except for the formula, is as follows:

[0149] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 1% barley extract composition, 5% D-panthenol, 2% oat kernel extract composition and the balance water were weighed.

[0150] Comparative Example 7

[0151] The same as Example 5, except for the formula, is as follows:

[0152] Calculate the mixture by mass: 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 1% barley extract composition, 5% D-panthenol, 2% gentian root extract composition, and the balance water.

[0153] Comparative Example 8

[0154] The same as Example 5, except for the formula, is as follows:

[0155] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 1.5% oat kernel extract composition, 5% D-panthenol, 1.5% gentian root extract composition and the balance water were weighed.

[0156] Comparative Example 9

[0157] The same as Example 5, except for the formula, is as follows:

[0158] Calculated by mass percentage, 20% niacinamide, 40% hydroxypropyl tetrahydropyrantriol, 1% p-hydroxyacetophenone, 5% glycerol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 3% barley extract composition, 5% D-panthenol and the balance water were weighed.

[0159] Creams were prepared according to the method of Example 4 using Example 5, Example 6, and Comparative Examples 6 to 9, and hyaluronidase inhibition experiments were performed to verify the soothing effects of each case.

[0160] The detection method is:

[0161] Macromolecular hyaluronic acid can inhibit inflammatory responses, thereby alleviating the discomfort caused by skin inflammation. Macromolecular hyaluronic acid degrades under the action of hyaluronidase, resulting in a decrease in macromolecular hyaluronic acid content. This degradation product, N-acetylglucosamine, is produced. Measuring the N-acetylglucosamine content in the reaction system indirectly reflects hyaluronidase activity.

[0162] The experimental method is:

[0163] 1. Weigh the sample;

[0164] 2. Pre-treating the sample groups to prepare a mixed solution;

[0165] 3. Add the reactants, mix well, and place in a water bath at 37°C;

[0166] 4. Add pH adjuster, boil in water for 10 minutes, and cool to room temperature;

[0167] 5. Measure the OD value on the test machine and calculate the hyaluronidase activity inhibition rate;

[0168] The above method is an in vitro method, and the N-acetylglucosamine content in the reaction system is measured to determine the inhibition rate of the sample group on hyaluronidase.

[0169] The test results can be found in Table 5;

[0170] Table 5

[0171] name Hyaluronidase inhibition rate (%) Example 5 43.68 Example 6 47.99 Comparative Example 6 36.43 Comparative Example 7 32.25 Comparative Example 8 42.92 Comparative Example 9 14.47 control group 3.41

[0172] Result analysis:

[0173] It can be seen from Example 5, Example 6, and Comparative Examples 6 to 9 that any combination of the barley extract composition, the gentian root extract composition, and the oat kernel extract composition can have a relatively obvious soothing effect; among them, the soothing effect of Comparative Example 8 is better than that of Comparative Example 6 and Comparative Example 7, and its effect is similar to that of Example 5, and the effect of Example 6 is better than that of Example 5;

[0174] These results suggest that the gentian root extract and oat kernel extract combination exerts the primary soothing effect, and that using both together provides the best results. Existing research also demonstrates that barley extract is merely a mild whitening and firming ingredient, with no data reporting its soothing properties.

[0175] When the three are used in combination, the soothing effect is not reduced due to the use of the barley extract composition, indicating that the gentian root extract composition, the oat kernel extract composition and the barley extract composition have good compatibility.

[0176] Another advantage of Example 5 over Comparative Example 8 is that it can exert a more significant anti-wrinkle and firming effect.

[0177] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A whitening, anti-wrinkle, firming and soothing multi-effect composition, characterized in that: The raw materials include the following components by mass percentage: 1-20% of niacinamide, 1-40% of hydroxypropyl tetrahydropyrantriol, 0.1-1% of p-hydroxyacetophenone, 1-5% of glycerin, 0.1-1% of 1,2-pentanediol, 0.1-1% of 1,2-hexanediol, 1-15% of barley extract composition, 1-5% of panthenol, 0.02-2% of gentian root extract composition, 0.02-2% of oat kernel extract composition and the balance of water.

2. The whitening, anti-wrinkle, firming and soothing multi-effect composition according to claim 1, characterized in that: The barley extract composition comprises raw materials including 45-55% of 1,3-propylene glycol, 1.8-2.2% of barley extract and the balance of water, calculated by mass percentage.

3. The whitening, anti-wrinkle, firming and soothing multi-effect composition according to claim 1, characterized in that: The raw materials of the gentian root extract composition include 4-6% of gentian root extract, 45-55% of butylene glycol and the balance of water, calculated by mass percentage.

4. The whitening, anti-wrinkle, firming and soothing multi-effect composition according to claim 1, characterized in that: The oat kernel extract composition comprises, by weight percentage, 4-6% of oat kernel extract, 20-30% of butanediol, 17-23% of 1,2-pentanediol and the balance of water.

5. The whitening, anti-wrinkle, firming and soothing multi-effect composition according to claim 1, characterized in that: The preparation method of the whitening, anti-wrinkle, firming and soothing multi-effect composition comprises the following steps: (1) Pour water into a production tank, stir and heat to 80-85°C, keep warm for 20-40 minutes, cool to 55-65°C, add niacinamide and hydroxypropyl tetrahydropyrantriol, mix, and cool to 40-50°C to prepare component A; (2) mixing p-hydroxyacetophenone, glycerol, 1,2-pentanediol and 1,2-hexanediol, and adding the mixture to component A to prepare component B; (3) The barley extract composition, panthenol, gentian root extract composition, and oat kernel extract composition are added to component B and mixed to prepare a whitening, anti-wrinkle, firming, and soothing multi-effect composition.

6. The whitening, anti-wrinkle, firming and soothing multi-effect composition according to claim 1, characterized in that: The raw materials include the following components by mass percentage: 10% niacinamide, 20% hydroxypropyl tetrahydropyrantriol, 0.5% p-hydroxyacetophenone, 3% glycerol, 0.5% 1,2-pentanediol, 0.5% 1,2-hexanediol, 7% barley extract composition, 3% panthenol, 1% gentian root extract composition, 1% oat kernel extract composition and the balance water.

7. Use of the whitening, anti-wrinkle, firming and soothing multi-effect composition according to any one of claims 1 to 6 in the preparation of a skin care product with skin whitening, firming, anti-wrinkle and soothing effects.

8. The use according to claim 7, characterized in that The skin care product is one of lotion, moisturizing lotion and facial cream.

9. The use according to claim 8, characterized in that The facial cream comprises, by mass percentage, 1-10% of glycerin, 0.01-0.1% of sodium polyacrylate, 0.01-1% of xanthan gum, 0.01-1% of hydrogenated lecithin, 0.01-0.1% of disodium EDTA, 0.04-4% of cetearyl olivate, 0.04-4% of sorbitan olivate, 1-6% of behenyl alcohol, 1-10% of caprylic / capric triglyceride, 1-5% of polydimethylsiloxane, 0.02-2% of tocopheryl acetate, 0.1-1% of p-hydroxyacetophenone, 1-5% of 1,3-propylene glycol, 0.02-2% of 1,2-pentanediol, 0.02-2% of 1,2-hexanediol, 1-30% of a whitening, anti-wrinkle, firming and soothing multi-effect composition, and the balance of water. Material A is prepared by mixing water, glycerin, sodium polyacrylate, xanthan gum, hydrogenated lecithin, and disodium EDTA; Material B is prepared by mixing cetearyl olivate, sorbitan olivate, behenyl alcohol, caprylic / capric triglyceride, dimethicone, and tocopheryl acetate; Material C was prepared by mixing p-hydroxyacetophenone, 1,3-propylene glycol, 1,2-pentanediol and 1,2-hexanediol.

10. The use according to claim 9, characterized in that The preparation method of the facial cream comprises the following steps: S1: Add material A into the production tank, homogenize at 2000-3000r / min for 8-20min, stir, and the temperature of the production tank is 83-85℃; S2: Add material B to the oil phase pot and stir. The oil phase pot temperature is 83-85℃; S3: Add material B obtained in step S2 into the production tank, homogenize at 2000-3000 r / min under vacuum for 10-20 min, keep at 83-85°C for 15-25 min, and start cooling. When the temperature drops to 42-45°C, material D is obtained; S4: Add material C and the whitening, anti-wrinkle, firming and soothing multi-effect composition to material D and mix to obtain a finished product.

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