Traditional Chinese medicine composition for tonifying qi and soothing nerves and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for tonifying qi and soothing nerves and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 500 to 510 parts of rhizoma polygonati, 500 to 510 parts of radix astragali seu hedysari, 100 to 110 parts of fructus lycii, 20 to 25 parts of fructus citri, 20 to 25 parts of rhizoma dioscoreae, 50 to 55 parts of fructus corni, 100 to 110 parts of radix rehmanniae praeparata, 50 to 55 parts of fructus rubi, 50 to 55 parts of fructus crataegi, 20 to 25 parts of herba lophatheri, 100 to 110 parts of fructus jujubae, 20 to 25 parts of rhizoma zingiberis recens and 20 to 25 parts of liquorice root. The preparation method comprises the following steps: firstly, extracting rhizoma polygonati, astragalus membranaceus, citron, Chinese yam, dogwood, prepared rehmannia root, hawthorn, lophatherum gracile and liquorice to prepare extract; then the extract is mixed and fermented with dried fructus lycii, raspberry, jujube and ginger, traditional Chinese medicine composition medicinal liquor is prepared, a 65% ethanol solution is adopted for dynamic heat reflux extraction, the extraction rate is increased, and the concentration of active ingredients of the medicinal liquor is directly increased; through two times of gradient extraction, target components are synergistically dissolved out, through gradient cooling and fractional extraction, the retention rate of thermosensitive components is increased, and the efficacy of the traditional Chinese medicine composition medicinal liquor is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for invigorating qi and calming the mind and a preparation method thereof. Background Art

[0002] Chinese invention patent CN116370556B discloses a Chinese medicinal composition for promoting blood circulation, removing blood stasis, invigorating qi and calming the mind, and its preparation method. The composition comprises the following components: ginsenosides, ruscosapogenin, danshensu, salvianolic acid B, schisandra chinensis, longan pulp polysaccharide, wolfberry polysaccharide, paeoniflorin, darutoside, β-ecdysterone, triterpenoid saponins, curcumin, sesquiterpene lactone, linalool, hesperidin, limonene, poria, orientale and liquorice. The active ingredients and Chinese medicinal ingredients synergistically enhance the effect of promoting the nourishment of yin and calming the mind by reducing free movement, improving qi and blood deficiency, and enhancing the effect of promoting blood circulation and removing blood stasis.

[0003] However, the preparation process of the above-mentioned traditional Chinese medicine composition requires high temperature and long time extraction, and the extraction efficiency of active ingredients is low. Therefore, the present application proposes a traditional Chinese medicine composition for invigorating qi and calming the mind and a preparation method thereof. Summary of the Invention

[0004] The object of the present invention is to provide a Chinese medicine composition for invigorating qi and calming the mind and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] According to a first aspect of the present invention, there is provided a traditional Chinese medicine composition for invigorating qi and calming the mind, the traditional Chinese medicine composition comprising the following components in parts by weight:

[0006] 500-510 parts of polygonatum, 500-510 parts of astragalus, 100-110 parts of wolfberry, 20-25 parts of citron, 20-25 parts of yam, 50-55 parts of cornus officinalis, 100-110 parts of rehmannia root, 50-55 parts of raspberry, 50-55 parts of hawthorn, 20-25 parts of bamboo leaf, 100-110 parts of jujube, 20-25 parts of ginger, and 20-25 parts of liquorice;

[0007] The polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice are extracted to prepare an extract;

[0008] The extract is mixed with dried wolfberry, raspberry, jujube and ginger for fermentation to prepare a Chinese medicine composition medicinal wine.

[0009] According to an embodiment of the present invention: it also includes: grain raw materials, which are composed of the following components in parts by weight: 700-750 parts of rice, 200-250 parts of sorghum, and 100-150 parts of corn.

[0010] According to an embodiment of the present invention, the steps of extracting polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice into an extract include:

[0011] Step 1: Grind polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice into 20-40 mesh particles in sequence, mix them evenly, and obtain a mixed material;

[0012] Step 2: mixing the mixed material with 65% ethanol solution to obtain a mixed solution;

[0013] Step 3, extracting the mixed solution twice by dynamic heat reflux;

[0014] Step 4: Combine the two extracts, filter through a 200-mesh sieve, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 60°C;

[0015] Step 5: Dry the thick paste in a vacuum drying oven at 60-65°C to a moisture content of ≤5%, and grind it through an 80-mesh sieve to obtain an extract.

[0016] Polygonatum sibiricum (nourishing yin) + Astragalus membranaceus (replenishing qi) + Rehmannia root (benefiting the kidneys) form the core efficacy module, which retains polysaccharide active substances through 65% ethanol solution to enhance immune regulation function.

[0017] According to an embodiment of the present invention: in step 2, the weight ratio of the mixed material to the 65% ethanol solution is 1:8-10.

[0018] According to an embodiment of the present invention: In step 3, the mixed solution is subjected to dynamic heat reflux extraction twice as follows:

[0019] First time: Bring to a boil and keep it simmering for 1.5 hours;

[0020] Second time: add solvent to the original volume and extract for 1 hour.

[0021] According to an embodiment of the present invention, the specific steps of the first mixed solution dynamic heat reflux extraction are:

[0022] Heating stage: Raise the temperature to boiling at a rate of 3°C / min to avoid local overheating that may cause gelatinization of starch components (yam);

[0023] Slightly boiling extraction: maintain a slightly boiling state of 80±2℃ for 1.5 hours; the temperature is ≤82℃ to prevent the decomposition of Polygonatum sibiricum polysaccharide, and the dynamic circulation flow rate is 500L / h (the solvent refluxes to the extraction tank through the condenser).

[0024] Circulation control: Turn on the circulation pump for 5 minutes every 20 minutes to force the solvent to flow, break the concentration boundary layer on the surface of the medicinal materials, and obtain an extract.

[0025] According to an embodiment of the present invention, the specific steps of the second mixed liquid dynamic heat reflux extraction are:

[0026] Rehydration: Add 65% ethanol to the initial solvent volume to compensate for evaporation losses and maintain the solubility balance of the active ingredients;

[0027] Secondary extraction: Extraction at 75±2℃ for 1 hour to reduce the temperature and reduce the degradation of heat-sensitive components;

[0028] Circulation control: The circulation pump is continuously turned on with a flow rate of 300 L / h to obtain a secondary extract.

[0029] According to a second aspect of the present invention, a method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind is provided, wherein the method comprises the following steps:

[0030] Step 1: extracting polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice to prepare an extract;

[0031] Step 2: After drying, wolfberry, raspberry, jujube, and ginger are crushed and mixed evenly to obtain auxiliary materials;

[0032] Step 3: Rice, sorghum and corn are mixed and cooked to obtain grain raw materials, and extract, auxiliary materials and distiller's yeast are added for fermentation;

[0033] Step 4: After fermentation, the wine is distilled and blended with ultra-filtered water to a 38° wine body.

[0034] According to an embodiment of the present invention: in step 3, the specific process of fermentation is:

[0035] Pre-fermentation: at 28-30℃, closed anaerobic, for 5 days;

[0036] Secondary fermentation: at 32-34°C for 7 days to promote esterification reaction, and test the mash every 24 hours: dynamically monitor the end point of fermentation and terminate when residual sugar is ≤0.5g / 100g;

[0037] After-ripening: Leave to stand for 3 days at 25℃ to achieve alcohol-acid-ester equilibrium, reduce the content of higher alcohols, and reduce the content of isopentanol to ≤0.4g / L, and fermentation is complete.

[0038] According to an embodiment of the present invention, the weight ratio of the grain raw material, the extract, the auxiliary material and the distiller's yeast is: 100:10:5:1;

[0039] The koji includes high-temperature Daqu and red yeast rice, and the weight ratio of the high-temperature Daqu to the red yeast rice is 1:1.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] The present invention first extracts polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice to prepare an extract; then the extract is mixed and fermented with dried wolfberry, raspberry, jujube and ginger to prepare a Chinese medicine composition medicinal wine, and a 65% ethanol solution is used for dynamic heat reflux extraction, which improves the extraction rate and directly leads to an increase in the concentration of active ingredients in the medicinal wine; two gradient extractions are performed, and the target ingredients are synergistically dissolved. Through gradient cooling and multiple extractions, the retention rate of heat-sensitive ingredients is improved, the basic integrity of medicinal substances is improved, and the transfer rate of active ingredients is high, thereby enhancing the efficacy of the Chinese medicine composition medicinal wine. DETAILED DESCRIPTION

[0042] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0043] The polygonatum, astragalus, wolfberry, citron, yam, cornus officinalis, rehmannia root, raspberry, hawthorn, bamboo leaf, jujube, ginger, and liquorice in the embodiments of the present invention can all be purchased from the market. There is no specific limitation on their sources.

[0044] Example 1

[0045] A method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind comprises the following steps:

[0046] Step 1, 500 parts of polygonatum, 500 parts of astragalus, 20 parts of citron, 20 parts of yam, 50 parts of cornus, 100 parts of rehmannia root, 50 parts of hawthorn, 20 parts of bamboo leaves and 20 parts of liquorice are successively ground into 20-40 mesh particles, mixed uniformly, and obtained a mixed material;

[0047] The mixed material was mixed with a 65% ethanol solution in a weight ratio of 1:9 to obtain a mixed solution;

[0048] The mixed solution was extracted twice by dynamic heat reflux:

[0049] The specific steps of the first dynamic hot reflux extraction of the mixed liquid are as follows: heating stage: heating to boiling at a rate of 3°C / min, micro-boiling extraction: maintaining a micro-boiling state of 80±2°C for 1.5 hours; circulation control: turning on the circulation pump for 5 minutes every 20 minutes to force the solvent to flow, breaking the concentration boundary layer on the surface of the medicinal material, and obtaining an extract.

[0050] The specific steps of the second dynamic reflux extraction of the mixed solution are as follows: rehydration: add 65% ethanol to the initial solvent volume to compensate for evaporation loss and maintain the solubility balance of the active ingredients; secondary extraction: extract at 75±2°C for 1 hour, lowering the temperature to reduce degradation of heat-sensitive components; circulation control: the circulation pump is continuously turned on at a flow rate of 300 L / h to obtain the secondary extract;

[0051] Combine the two extracts, filter through a 200-mesh sieve, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 60°C;

[0052] The thick paste was dried in a vacuum drying oven at 60°C to a moisture content of ≤5%, and then pulverized through an 80-mesh sieve to obtain an extract;

[0053] Step 2: Dry 100 parts of wolfberries, 50 parts of raspberries, 100 parts of jujubes, and 20 parts of ginger, crush them, and mix them evenly to obtain an auxiliary material;

[0054] Step 3: 700 parts of rice, 200 parts of sorghum, and 100 parts of corn are mixed and cooked to obtain a grain raw material, and extract, auxiliary materials, and distiller's yeast are added for fermentation. The weight ratio of the grain raw material, extract, auxiliary materials, and distiller's yeast is 100:10:5:1;

[0055] The specific fermentation process is as follows: pre-fermentation: at 28-30℃, closed and anaerobic, for 5 days; mid-fermentation: at 32-34℃, for 7 days, to promote esterification reaction, and test the mash every 24 hours: dynamically monitor the fermentation end point, and terminate when residual sugar ≤0.5g / 100g; post-ripening: at 25℃, stand for 3 days, alcohol-acid-ester balance, reduce the content of higher alcohols, isopentanol ≤0.4g / L, and fermentation is completed.

[0056] The koji includes high-temperature Daqu and red yeast rice, and the weight ratio of the high-temperature Daqu to the red yeast rice is 1:1.

[0057] Step 4: After fermentation, the wine is distilled and blended with ultra-filtered water to a 38° wine body.

[0058] Example 2

[0059] A method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind comprises the following steps:

[0060] Step 1, 510 parts of polygonatum, 510 parts of astragalus, 25 parts of citron, 25 parts of yam, 55 parts of cornus, 110 parts of rehmannia root, 55 parts of hawthorn, 25 parts of loblolly bamboo leaf and 25 parts of liquorice are successively ground into 20-40 mesh particles, mixed uniformly, and obtained a mixed material;

[0061] The mixed material was mixed with a 65% ethanol solution in a weight ratio of 1:9 to obtain a mixed solution;

[0062] The mixed solution was extracted twice by dynamic heat reflux:

[0063] The specific steps of the first dynamic hot reflux extraction of the mixed liquid are as follows: heating stage: heating to boiling at a rate of 3°C / min, micro-boiling extraction: maintaining a micro-boiling state of 80±2°C for 1.5 hours; circulation control: turning on the circulation pump for 5 minutes every 20 minutes to force the solvent to flow, breaking the concentration boundary layer on the surface of the medicinal material, and obtaining an extract.

[0064] The specific steps of the second dynamic reflux extraction of the mixed solution are as follows: rehydration: add 65% ethanol to the initial solvent volume to compensate for evaporation loss and maintain the solubility balance of the active ingredients; secondary extraction: extract at 75±2°C for 1 hour, lowering the temperature to reduce degradation of heat-sensitive components; circulation control: the circulation pump is continuously turned on at a flow rate of 300 L / h to obtain the secondary extract;

[0065] Combine the two extracts, filter through a 200-mesh sieve, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 60°C;

[0066] The thick paste was dried in a vacuum drying oven at 60°C to a moisture content of ≤5%, and then pulverized through an 80-mesh sieve to obtain an extract;

[0067] Step 2: Dry 110 parts of wolfberries, 55 parts of raspberries, 110 parts of jujubes, and 25 parts of ginger, crush them, and mix them evenly to obtain an auxiliary material;

[0068] Step 3: 750 parts of rice, 250 parts of sorghum, and 150 parts of corn are mixed and cooked to obtain a grain raw material, and extract, auxiliary materials, and distiller's yeast are added for fermentation. The weight ratio of the grain raw material, extract, auxiliary materials, and distiller's yeast is 100:10:5:1;

[0069] The specific fermentation process is as follows: pre-fermentation: at 28-30℃, closed and anaerobic, for 5 days; mid-fermentation: at 32-34℃, for 7 days, to promote esterification reaction, and test the mash every 24 hours: dynamically monitor the fermentation end point, and terminate when residual sugar ≤0.5g / 100g; post-ripening: at 25℃, stand for 3 days, alcohol-acid-ester balance, reduce the content of higher alcohols, isopentanol ≤0.4g / L, and fermentation is completed.

[0070] The koji includes high-temperature Daqu and red yeast rice, and the weight ratio of the high-temperature Daqu to the red yeast rice is 1:1.

[0071] Step 4: After fermentation, the wine is distilled and blended with ultra-filtered water to a 38° wine body.

[0072] Comparative Example 1

[0073] A method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind comprises the following steps:

[0074] Step 1, 500 parts of polygonatum, 500 parts of astragalus, 20 parts of citron, 20 parts of yam, 50 parts of cornus, 100 parts of rehmannia root, 50 parts of hawthorn, 20 parts of bamboo leaves and 20 parts of liquorice are successively ground into 20-40 mesh particles, mixed uniformly, and obtained a mixed material;

[0075] Step 2: Dry 100 parts of wolfberries, 50 parts of raspberries, 100 parts of jujubes, and 20 parts of ginger, crush them, and mix them evenly to obtain an auxiliary material;

[0076] Step 3: 700 parts of rice, 200 parts of sorghum, and 100 parts of corn are mixed and cooked to obtain a grain raw material, and the mixed material, auxiliary materials, and distiller's yeast are added for fermentation. The weight ratio of the grain raw material, the mixed material, the auxiliary materials, and the distiller's yeast is 100:10:5:1;

[0077] The specific fermentation process is as follows: pre-fermentation: at 28-30℃, closed and anaerobic, for 5 days; mid-fermentation: at 32-34℃, for 7 days, to promote esterification reaction, and test the mash every 24 hours: dynamically monitor the fermentation end point, and terminate when residual sugar ≤0.5g / 100g; post-ripening: at 25℃, stand for 3 days, alcohol-acid-ester balance, reduce the content of higher alcohols, isopentanol ≤0.4g / L, and fermentation is completed.

[0078] The koji includes high-temperature Daqu and red yeast rice, and the weight ratio of the high-temperature Daqu to the red yeast rice is 1:1.

[0079] Step 4: After fermentation, the wine is distilled and blended with ultra-filtered water to a 38° wine body.

[0080] The difference between Comparative Example 1 and Example 1 is that the mixed material is not extracted to prepare the extract, and the weight parts of the composition are the same as those of the other preparation methods.

[0081] Test example: immune function experiment;

[0082] Sample selection: 48 mice of similar size and weight (weight 20±2g) were selected and divided into four groups: experimental group 1, experimental group 2, positive control group and blank control group;

[0083] Administration: Oral administration (dosage of 0.25 mL / 20 g), once a day for 14 consecutive days. The mice in experimental group 1 were administered with the 38° wine prepared in Example 1, the mice in experimental group 2 were administered with the 38° wine prepared in Example 2, the mice in the positive control group were administered with the 38° wine prepared in Comparative Example 1, and the mice in the blank control group were administered with normal saline.

[0084] Experimental steps:

[0085] Modeling: Except for the blank control group, the other groups were intraperitoneally injected with cyclophosphamide (80 mg / kg, qd×3d) to establish the immunosuppressive model.

[0086] Drug administration: The mice were divided into groups and given drugs for 14 days after model establishment.

[0087] Detection: 24 hours after the last administration: blood was collected and serum IgG and IL-2 were measured by ELISA;

[0088] The spleen was removed and the spleen index (spleen weight mg / body weight g) was calculated;

[0089] Flow cytometry to measure CD4 + / CD8 + T cell ratio;

[0090] The test data is shown in Table 1 below:

[0091] Table 1 Immunity test table

[0092] Group Spleen index (mg / g) IgG (μg / mL) IL-2 (pg / mL) <![CDATA[CD4 + / CD8 + ]]> Experimental Group 1 3.8±0.3## 898±79## 32.1±2.8## 1.59±0.12## Experimental Group 2 4.5±0.4## 998±91## 37.2±3.0## 1.77±0.16## Positive control group 4.1±0.4# 912±89# 34.8±3.1# 1.68±0.14# Blank control group 4.8±0.3 1052±98 38.5±3.2 1.82±0.15 Model Group 2.9±0.2* 623±75* 21.7±2.1* 1.21±0.11*

[0093] In the table, * indicates that the difference is <0.01 compared with the blank control group, which is extremely significant; # indicates that the difference is significantly effective compared with the model group, which is P<0.05; ## indicates that the difference is significantly effective compared with the model group, which is P<0.01; data are expressed as mean ± standard deviation.

[0094] Spleen index (mg / g) indicates the developmental status of immune organs; a larger value indicates enhanced immunity; IgG (μg / mL) indicates the core antibody of humoral immunity; a higher value indicates stronger humoral immunity; IL-2 (pg / mL) indicates the key factor for T cell activation; a higher value indicates stronger cellular immunity; CD4 + / CD8 + It represents a key indicator of immune balance (normal value 1.5-2.0), and the recovery of the ratio indicates the restoration of immune homeostasis.

[0095] The data in the above table show that the Chinese medicine composition wine prepared by the present application significantly improves the spleen index, humoral immunity (IgG), cellular immunity (IL-2, CD4 + / CD8 + ), the effect of experimental group 1-2 was better than that of the positive control group, which proved that the Chinese medicine composition wine prepared in this application has the effect of invigorating qi and calming the mind.

[0096] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0097] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for invigorating qi and calming the mind, characterized in that: The Chinese medicine composition is composed of the following components in parts by weight: 500-510 parts of polygonatum, 500-510 parts of astragalus, 100-110 parts of wolfberry, 20-25 parts of citron, 20-25 parts of yam, 50-55 parts of cornus officinalis, 100-110 parts of rehmannia root, 50-55 parts of raspberry, 50-55 parts of hawthorn, 20-25 parts of bamboo leaf, 100-110 parts of jujube, 20-25 parts of ginger, and 20-25 parts of liquorice; The polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice are extracted to prepare an extract; The extract is mixed with dried wolfberry, raspberry, jujube and ginger for fermentation to prepare a Chinese medicine composite medicinal wine.

2. A traditional Chinese medicine composition for invigorating qi and calming the mind according to claim 1, characterized in that: Also includes: The grain raw material consists of the following components in parts by weight: 700-750 parts of rice, 200-250 parts of sorghum, and 100-150 parts of corn.

3. A Chinese medicine composition for invigorating qi and calming the mind according to claim 2, characterized in that: The specific steps of extracting polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice into an extract include: Step 1: Grind polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice into 20-40 mesh particles in sequence, mix them evenly, and obtain a mixed material; Step 2: mixing the mixed material with 65% ethanol solution to obtain a mixed solution; Step 3, extracting the mixed solution twice by dynamic heat reflux; Step 4: Combine the two extracts, filter through a 200-mesh sieve, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.20-1.25 at 60°C; Step 5: Dry the thick paste in a vacuum drying oven at 60-65°C to a moisture content of ≤5%, and grind it through an 80-mesh sieve to obtain an extract.

4. A Chinese medicine composition for invigorating qi and calming the mind according to claim 3, characterized in that: In step 2, the weight ratio of the mixed material to the 65% ethanol solution is 1:8-10.

5. A Chinese medicine composition for invigorating qi and calming the mind according to claim 4, characterized in that: In step 3, the mixed solution is subjected to dynamic heat reflux extraction twice as follows: First time: Bring to a boil and keep it simmering for 1.5 hours; Second time: add solvent to the original volume and extract for 1 hour.

6. A Chinese medicine composition for invigorating qi and calming the mind according to claim 5, characterized in that: The specific steps of the first mixed solution dynamic heat reflux extraction are: Heating stage: heating to boiling at a rate of 3°C / min; Slightly boiling extraction: maintain a slightly boiling state at 80±2℃ for 1.5 hours; Circulation control: Turn on the circulation pump for 5 minutes every 20 minutes to force the solvent to flow, break the concentration boundary layer on the surface of the medicinal materials, and obtain an extract.

7. A Chinese medicine composition for invigorating qi and calming the mind according to claim 6, characterized in that: The specific steps of the second mixed solution dynamic heat reflux extraction are: Rehydration: Add 65% ethanol to the initial solvent volume to compensate for evaporation losses and maintain the solubility balance of the active ingredients; Secondary extraction: Extraction at 75±2℃ for 1 hour to reduce the temperature and reduce the degradation of heat-sensitive components; Circulation control: The circulation pump is continuously turned on with a flow rate of 300 L / h to obtain a secondary extract.

8. The method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind according to claim 7, characterized in that: The following steps are involved: Step 1: extracting polygonatum, astragalus, citron, yam, cornus officinalis, rehmannia root, hawthorn, bamboo leaf and liquorice to prepare an extract; Step 2: After drying, wolfberry, raspberry, jujube, and ginger are crushed and mixed evenly to obtain auxiliary materials; Step 3: Rice, sorghum and corn are mixed and cooked to obtain grain raw materials, and extract, auxiliary materials and distiller's yeast are added for fermentation; Step 4: After fermentation, the wine is distilled and blended with ultra-filtered water to a 38° wine body.

9. The method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind according to claim 8, characterized in that: In step 3, the specific process of fermentation is: Pre-fermentation: at 28-30℃, closed anaerobic, for 5 days; Secondary fermentation: at 32-34°C for 7 days to promote esterification reaction, and test the mash every 24 hours: dynamically monitor the end point of fermentation and terminate when residual sugar is ≤0.5g / 100g; After-ripening: Leave to stand for 3 days at 25℃ to achieve alcohol-acid-ester equilibrium, reduce the content of higher alcohols, and reduce the content of isopentanol to ≤0.4g / L, and fermentation is complete.

10. The method for preparing a traditional Chinese medicine composition for invigorating qi and calming the mind according to claim 8, characterized in that: The weight ratio of grain raw materials, extract, auxiliary materials and distiller's yeast is: 100:10:5:1; The koji includes high-temperature Daqu and red yeast rice, and the weight ratio of the high-temperature Daqu to the red yeast rice is 1:1.