Multi-channel electrical stimulation device based on skin impedance

Abstract

The invention provides a multi-channel electrical stimulation device based on skin impedance, and the device comprises a control module which is used for receiving an external control signal and a skin impedance signal, and outputting an internal control signal according to the received signal; the electrical stimulation output module is connected with the control module and used for outputting corresponding electrical stimulation current according to the control signal; the electrode connection module is connected with the electrical stimulation output module and is used for transmitting the electrical stimulation current; the electrode module is connected with the electrode connection module, outputs electrical stimulation current to the skin and transmits the collected skin impedance information to the electrode connection module; and the impedance detection module is respectively connected with the electrode connection module and the control module, converts the skin impedance information transmitted by the electrode connection module into a skin impedance signal and transmits the skin impedance signal to the control module so as to update the skin impedance signal. And the electrical stimulation parameters are optimally regulated and controlled according to the measured skin impedance, so that accurate treatment is realized.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a multi-channel electrical stimulation device based on skin impedance. Background Art

[0002] As electrical stimulation technology matures, it is increasingly being used in various fields, especially in the fields of pain treatment and rehabilitation. Human body impedance often reflects the condition of muscles to a certain extent, and studies have shown that a decrease in impedance will reflect changes related to physical pain. Therefore, by detecting the human skin impedance signal and controlling the electrical stimulation parameters according to a preset algorithm, feedback can be achieved. However, in the existing technology, impedance detection and electrical stimulation treatment are mostly achieved through two independent devices to achieve each other's functions, and the compatibility of the two when combined is poor. Summary of the Invention

[0003] The present invention is made to solve the above problems, and its purpose is to provide a multi-channel electrical stimulation device based on skin impedance.

[0004] The present invention provides a multi-channel electrical stimulation device based on skin impedance, which has the following characteristics: a control module, which is used to receive external control signals and skin impedance signals and output internal control signals according to the received signals; an electrical stimulation output module, which is connected to the control module and is used to output corresponding electrical stimulation current according to the internal control signal; an electrode connection module, which is connected to the electrical stimulation output module and is used to transmit electrical stimulation current; an electrode module, which is connected to the electrode connection module and is used to output electrical stimulation current to the skin and transmit collected skin impedance information to the electrode connection module; an impedance detection module, which is respectively connected to the electrode connection module and the control module, and is used to convert the skin impedance information transmitted by the electrode connection module into a skin impedance signal and transmit it to the control module, so as to update the skin impedance signal of the control module; wherein the internal control signal includes: a conduction control signal, an amplitude control signal and a polarity control signal, wherein the polarity control signal includes a frequency control signal and a pulse width control signal; the electrode connection module is also used to isolate the output of the electrical stimulation output module from interfering with the impedance detection module.

[0005] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein, the control module is configured as: active adjustment mode and intelligent adjustment mode; in the active adjustment mode, the corresponding stimulation parameters are adjusted based on the input parameter control signal; in the intelligent adjustment mode, stimulation is alternately performed at frequencies of 2 Hz and 100 Hz, each frequency lasting 10 seconds, and the human skin impedance is detected every five minutes, which is used as input to predict the optimal treatment frequency and pulse width, and transmitted to the control module for parameter implementation.

[0006] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein, the control module also uses a random forest model based on the skin impedance signal, traverses the treatment intensity and pulse width, and predicts the parameter combination that can cause the best change in the skin impedance signal.

[0007] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein, the electrical stimulation output module includes: a channel enabling unit, connected to the control module, for adjusting the conduction state of the channel according to the conduction control signal; a boosting unit, connected to the control module, for adjusting the amplitude of the electrical stimulation current according to the amplitude control signal; a polarity conversion unit, connected to the control module, for converting the type of electrical stimulation current from continuous current to bipolar pulse current according to the polarity control signal, and controlling the output frequency and pulse width.

[0008] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein, the channel enabling unit includes: a first resistor, a first end of which is connected to the control module through the EN1 network; a first MOSFET tube, a gate of the first MOSFET tube is connected to the second end of the first resistor, a source is connected to the power supply VCC, and a drain is connected to the boost unit.

[0009] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein, the boost unit includes: a first capacitor, a first end of which is connected to the control module through the PWM1 network; a first logic operation chip, the first pin and the eighth pin of the first logic operation chip are both connected to the power supply VCC, the second pin is connected to the second end of the first capacitor, the third pin, the fifth pin and the sixth pin are not connected, and the fourth pin is grounded; a second resistor, a first end is grounded, and the second end is connected to the second pin; a second capacitor, a first end is grounded; a first inductor, connected to the second end of the second capacitor; a first transistor, the collector of the first transistor is connected to the second end of the first inductor, and the emitter is grounded; a third resistor, a first end is connected to the seventh pin of the first logic operation chip, and the second end is connected to the base of the first transistor; a first diode, a first end is connected to the second end of the first inductor; a fourth resistor, a first end is connected to the second end of the first diode; a fifth resistor, a first end is connected to the second end of the fourth resistor, and the second end is grounded; a third capacitor, a first end is connected to the second end of the first diode, and the second end is grounded.

[0010] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein the polarity conversion unit includes: a sixth resistor, a first end of which is connected to the control module via the CON1 network; a second transistor, a base of which is connected to the second end of the sixth resistor, and an emitter is grounded; a seventh resistor, a first end of which is connected to the second end of the first diode, and a second end of which is connected to the collector of the second transistor;

[0011] a third transistor, the base of the third transistor being connected to the collector of the second transistor, and the collector being connected to the second end of the seventh resistor; an eighth resistor, a first end being connected to the emitter of the third transistor, and a second end being connected to the control module via the 1A1 network; a fourth transistor, an emitter being connected to the second end of the eighth resistor, a base being connected to the collector of the second transistor, and the collector being grounded;

[0012] A ninth resistor, having a first end connected to the first end of the seventh resistor; a fifth transistor, having a collector connected to the first end of the seventh resistor; a tenth resistor, having a first end connected to the control module via the CON2 network; a sixth transistor, having a collector respectively connected to the second end of the ninth resistor and the base of the fifth transistor, a base connected to the second end of the tenth resistor, and an emitter connected to ground; an eleventh resistor, having a first end connected to the emitter of the fifth transistor, and a second end connected to the control module via the 1A2 network; a seventh transistor, having an emitter connected to the second end of the eleventh resistor, a base connected to the collector of the sixth transistor, and a collector grounded.

[0013] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein the impedance detection module includes: a second logic operation chip, the first pin of which is connected to the control module via the VIN network. The fifth pin of which is connected to the control module via the VOUT network; a twelfth resistor, the first end of which is connected to the VIN network and the second end of which is connected to the second pin of the second logic operation chip; a thirteenth resistor, the first end of which is connected to the VIN network and the second end of which is connected to the third pin of the second logic operation chip; a fourteenth resistor, the first end of which is connected to the VIN network and the second end of which is connected to the fourth pin of the second logic operation chip;

[0014] A fifteenth resistor, having a first end connected to the power supply VCC; a sixteenth resistor, having a first end connected to ground; a first amplifier, having a non-inverting input end connected to the second end of the fifteenth resistor and the second end of the sixteenth resistor, respectively, and an inverting input end connected to the control module via the VIN network; a seventeenth resistor, having a first end connected to the power supply VCC; an eighteenth resistor, having a first end connected to ground; a second amplifier, having a positive power supply end connected to the power supply VCC, a negative power supply end connected to ground, an inverting input end and an output end both connected to the VOUT network, and a non-inverting input end connected to the second end of the seventeenth resistor and the second end of the eighteenth resistor, respectively; a nineteenth resistor, having a first end connected to the inverting input end of the first amplifier, and a second end connected to the output end of the first amplifier; a twentieth resistor, having a first end connected to the output end of the first amplifier;

[0015] a twenty-first resistor, having a first end connected to the second end of the twentieth resistor; a fourth capacitor, having a first end connected to the non-inverting input terminal of the second amplifier; a third logic operation chip, having a fourth pin connected to the second end of the twenty-first resistor, a fifth pin connected to the second end of the twentieth resistor, and a sixth pin connected to the second end of the fourth capacitor; a tenth pin and an eleventh pin connected to a power supply VCC; a thirteenth pin and a fourteenth pin connected to ground; a fifteenth pin connected to the control module via an I2C1SCL network; and a sixteenth pin connected to the control module via an I2C1SDA network; a twenty-second resistor, having a first end connected to the power supply VCC and a second end connected to the control module via an I2C1SCL network;

[0016] The twenty-third resistor has a first end connected to the twelfth pin of the third logic operation chip, and a second end connected to the ground; the twenty-fourth resistor has a first end connected to the ninth pin of the third logic operation chip, and a second end connected to the power supply VCC; the twenty-fifth resistor has a first end connected to the power supply VCC, and a second end connected to the control module via the I2C1SDA network; the fifth capacitor has a first end connected to the ninth pin of the third logic operation chip, and a second end connected to the ground; the sixth capacitor has a first end connected to the second end of the twenty-fourth resistor, and a second end connected to the ground; the seventh capacitor has a first end connected to the second end of the twenty-fourth resistor, and a second end connected to the ground.

[0017] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have the following features: wherein the impedance detection module obtains skin impedance information, amplifies and filters the skin impedance information, converts the AD into the real impedance part and the imaginary impedance part, and obtains the actual impedance through the following formula and transmits it to the control module:

[0018] Z=1 / (G*A)

[0019] Where Z is the actual measured impedance, G is the gain proportional coefficient, and A is the impedance amplitude;

[0020]

[0021] Where Re is the real part of impedance and Im is the imaginary part of impedance.

[0022] The multi-channel electrical stimulation device based on skin impedance provided by the present invention may also have such features, further comprising: an emergency stop module, connected to the electrical stimulation output module, for closing the channel of the electrical stimulation output module, so that the electrical stimulation input module stops outputting current. A display module, connected to the control module, for displaying the working status of each module. A power supply module, respectively connected to the control module, the electrical stimulation output module and the impedance detection module, for converting the battery voltage into a target voltage to supply power to each module and managing the battery charging.

[0023] Functions and effects of the invention

[0024] According to the present invention, it includes: a control module for receiving an external control signal and a skin impedance signal and outputting an internal control signal according to the received signal; an electrical stimulation output module connected to the control module for outputting a corresponding electrical stimulation current according to the control signal; an electrode connection module connected to the electrical stimulation output module for transmitting the electrical stimulation current; an electrode module connected to the electrode connection module for outputting the electrical stimulation current to the skin and transmitting the collected skin impedance information to the electrode connection module; an impedance detection module connected to the electrode connection module and the control module respectively for converting the skin impedance information transmitted by the electrode connection module into a skin impedance signal and transmitting it to the control module for updating the skin impedance signal of the control module; wherein the internal control signal includes: a conduction control signal, an amplitude control signal and a polarity control signal, wherein the polarity control signal further includes a frequency control signal and a pulse width control signal; the electrode connection module is also used to isolate the output of the electrical stimulation output module from interfering with the impedance detection module. Therefore, the multi-channel electrical stimulation device based on skin impedance of the present invention applies electrical stimulation current to the skin through multiple channels and collects skin impedance, and then optimally regulates the electrical stimulation parameters according to the measured skin impedance to achieve precise treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 3 is a schematic diagram of a module of a multi-channel electrical stimulation device based on skin impedance in an embodiment of the present invention.

[0026] Figure 2 is a circuit diagram of the electrical stimulation output module in an embodiment of the present invention.

[0027] Figure 3 4 is a circuit diagram of an impedance detection module in an embodiment of the present invention.

[0028] Figure 4 4 is a circuit diagram of an electrode connection module in an embodiment of the present invention.

[0029] Figure 5 This is a control flow chart of a multi-channel electrical stimulation device based on skin impedance in an embodiment of the present invention. DETAILED DESCRIPTION

[0030] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections, electrical connections, or mutual communication; they can refer to direct connections or indirect connections through an intermediate medium; they can refer to internal communication between two components or the interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on specific circumstances.

[0031] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the following embodiments and accompanying drawings specifically illustrate the multi-channel electrical stimulation device based on skin impedance of the present invention.

[0032] Example

[0033] Figure 1 3 is a schematic diagram of a module of a multi-channel electrical stimulation device based on skin impedance in an embodiment of the present invention.

[0034] like Figure 1 As shown, this embodiment provides a multi-channel electrical stimulation device 100 based on skin impedance, including: a control module 1, an electrical stimulation output module 2, an electrode connection module 3, an electrode module 4, and an impedance detection module 5.

[0035] The control module 1 is used to receive an external control signal and a skin impedance signal and output an internal control signal according to the received signal. The internal control signal includes: a conduction control signal, an amplitude control signal and a polarity control signal.

[0036] In this embodiment, the control module 1 is an MCU (Microcontroller Unit).

[0037] The control module 1 is configured as follows: active adjustment mode and intelligent adjustment mode: in the active adjustment mode, the stimulation parameters are adjusted based on the input parameters; in the intelligent adjustment mode, the stimulation is alternately performed at frequencies of 2 Hz and 100 Hz, with each frequency lasting 10 seconds, and the human skin impedance is detected every five minutes, which is used as input to predict the optimal treatment frequency and pulse width, and transmitted to the control module for parameter implementation.

[0038] Figure 2 is a circuit diagram of the electrical stimulation output module in an embodiment of the present invention.

[0039] like Figure 2 As shown, the electrical stimulation output module 2 is connected to the control module 1 and is used to output the corresponding electrical stimulation current according to the internal control signal. The electrical stimulation output module includes multiple channels for transmitting the electrical stimulation current.

[0040] The electrical stimulation output module 2 includes: a channel enabling unit 21 , a boosting unit 22 , and a polarity conversion unit 23 .

[0041] The channel enabling unit 21 is connected to the control module 1 and is used to adjust the conduction state of the channel according to the conduction control signal.

[0042] The channel enabling unit 21 includes: a first resistor R2, a first MOSFET tube Q1

[0043] A first resistor R2, a first end of which is connected to the control module 1 via the EN1 network;

[0044] The first MOSFET tube Q1 has a gate connected to the second end of the first resistor R2 , a source connected to the power supply VCC, and a drain connected to the boost unit 22 .

[0045] The boost unit 22 is connected to the control module 1 and is used to adjust the amplitude of the electrical stimulation current according to the amplitude control signal. In this embodiment, the boost unit 22 boosts the 3.3V supply voltage to a maximum of 100V electrical stimulation output voltage to provide the constant voltage required for electrical stimulation.

[0046] The boost unit 22 includes: a first capacitor C1, a first logic operation chip U1, a second resistor R1, a second capacitor C2, a first inductor L1, a first transistor Q2, a third resistor R3, a first diode D1, a fourth resistor R4, a fifth resistor R5, and a third capacitor C3.

[0047] A first end of the first capacitor C1 is connected to the control module 1 through the PWM1 network.

[0048] The first logic operation chip U1 has its first pin and eighth pin connected to the power supply VCC, its second pin connected to the second end of the first capacitor C1, its third pin, fifth pin and sixth pin unconnected, and its fourth pin grounded.

[0049] A first end of the second resistor R1 is grounded, and a second end is connected to the second pin.

[0050] A first terminal of the second capacitor C2 is grounded.

[0051] The first inductor L1 is connected to the second end of the second capacitor C2.

[0052] The collector of the first transistor Q2 is connected to the second end of the first inductor L1 , and the emitter is grounded.

[0053] A first end of the third resistor R3 is connected to the seventh pin of the first logic operation chip U1 , and a second end thereof is connected to the base of the first transistor Q2 .

[0054] A first end of the first diode D1 is connected to a second end of the first inductor L1 .

[0055] A first end of the fourth resistor R4 is connected to the second end of the first diode D1 .

[0056] A first end of the fifth resistor R5 is connected to the second end of the fourth resistor R4 , and a second end thereof is grounded.

[0057] A first end of the third capacitor C3 is connected to the second end of the first diode D1 , and a second end thereof is grounded.

[0058] The control waveform output by control module 1 is connected to the PWM1 network. After passing through a high-pass filter formed by the first capacitor C1 and the second resistor R1 to filter out any interference, it is input to the first logic chip U1 for a logical AND operation with a 3.3V continuous high voltage, which then serves as the control signal for turning the first transistor Q2 on or off. When the first diode D2 is turned on, the first inductor L1 is charged. When the first diode D2 is turned off, the first inductor L1 generates a reverse voltage to prevent sudden current changes, providing voltage to the third capacitor C3. The power supply itself also boosts the voltage of the third capacitor C3. The final voltage amplitude can be roughly calculated as VOUT = (1 / (1-D))VIN, where VOUT is the output voltage, VIN is the input voltage, and D is the high-level duty cycle of the PWM waveform that controls the transistor on and off.

[0059] The polarity conversion unit 23 is connected to the control module 1 and is used to convert the type of the electrical stimulation current from a continuous current to a bipolar pulse current according to the polarity control signal.

[0060] The polarity conversion unit 23 includes a sixth resistor R6, a second transistor Q3, a seventh resistor R7, a third transistor Q4, an eighth resistor R8, a fourth transistor Q5, a ninth resistor R9, a fifth transistor Q6, a tenth resistor R10, a sixth transistor Q7, an eleventh resistor R11, and a seventh transistor Q8.

[0061] A first end of the sixth resistor R6 is connected to the control module 1 through the CON1 network.

[0062] The base of the second transistor Q3 is connected to the second end of the sixth resistor R6 , and the emitter is grounded.

[0063] a seventh resistor R7, having a first end connected to the second end of the first diode D1, and a second end connected to the collector of the second transistor Q3;

[0064] The base of the third transistor Q4 is connected to the collector of the second transistor Q3 , and the collector is connected to the second end of the seventh resistor R7 .

[0065] A first end of the eighth resistor R8 is connected to the emitter of the third transistor Q4 , and a second end thereof is connected to the control module 1 via the 1A1 network.

[0066] The emitter of the fourth transistor Q5 is connected to the second end of the eighth resistor R8 , the base is connected to the collector of the second transistor Q3 , and the collector is grounded.

[0067] A first end of the ninth resistor R9 is connected to a first end of the seventh resistor R7 .

[0068] The collector of the fifth transistor Q6 is connected to the first end of the seventh resistor R7.

[0069] A first end of the tenth resistor R10 is connected to the control module 1 via the CON2 network.

[0070] The collector of the sixth transistor Q7 is respectively connected to the second end of the ninth resistor R9 and the base of the fifth transistor Q6 , the base is connected to the second end of the tenth resistor R10 , and the emitter is grounded.

[0071] A first end of the eleventh resistor R11 is connected to the emitter of the fifth transistor Q6 , and a second end thereof is connected to the control module 1 via the 1A2 network.

[0072] The emitter of the seventh transistor Q8 is connected to the second end of the eleventh resistor R11 , the base is connected to the collector of the sixth transistor Q7 , and the collector is grounded.

[0073] The first circuit includes an eighth resistor R8, a third transistor Q4, an eighth resistor R8, a seventh transistor Q8, a sixth transistor Q7, and a tenth resistor R10.

[0074] The second circuit includes: a ninth resistor R9, a fifth transistor Q6, an eleventh resistor R11, a fourth transistor Q5, a second transistor Q3, and a sixth resistor R6.

[0075] The first circuit and the second circuit have completely symmetrical structures, and only one circuit can work at most at the same time;

[0076] The first circuit and the second circuit are connected to the electrode connection module 3 and work in time-sharing mode so that the electrical stimulation current flows through only one of the circuits, and the control of the relevant parameters of the entire electrical stimulation output is achieved by controlling the frequency and pulse width of the circuit.

[0077] The control module 1 outputs a control waveform to the CON1 network and the CON2 network to control the states of the second transistor Q3 and the sixth transistor Q7, respectively. The first part is analyzed below. When CON1 is at a high level, the second transistor Q3 is turned on and the base voltage of the third transistor Q4 is 0V, so the third transistor Q4 is turned off. Similarly, when CON2 is at a high level, the fifth transistor Q6 is turned off. When CON1 is at a low level, the second transistor Q3 is turned off and the third transistor Q4 is turned on. At this time, the pulse current passes through the third transistor Q4 to the eighth resistor R8, and then through the 1A1 and 1A2 networks to the seventh transistor Q8 and connected to the ground, forming a loop.

[0078] Electrode module 4 is connected to electrode connection module 3 and is used to output electrical stimulation current to the skin and transmit the collected skin impedance information to electrode connection module 3. The electrode module includes: electrical stimulation electrodes and impedance detection electrodes. The electrical stimulation electrodes are used to transmit current to the human body, and the impedance detection electrodes are used to collect human skin impedance information.

[0079] The impedance detection module 5 is connected to the electrode connection module and the control module 1 respectively, and is used to convert the skin impedance information into a skin impedance signal and transmit it to the control module 1 for updating the skin impedance signal of the control module 1.

[0080] Figure 3 4 is a circuit diagram of an impedance detection module in an embodiment of the present invention.

[0081] like Figure 3 As shown, the impedance detection module 5 includes: a second logic operation chip H1, a twelfth resistor R12, a thirteenth resistor R13, a fourteenth resistor R14, a fifteenth resistor R15, a sixteenth resistor R16, a first amplifier U2.2, a seventeenth resistor R17, an eighteenth resistor R18, a second amplifier U2.1, a nineteenth resistor R19, a twentieth resistor R20, a twenty-first resistor R21, a fourth capacitor C4, a third logic operation chip U3, a twenty-second resistor R22, a twenty-third resistor R23, a twenty-fourth resistor R24, a twenty-fifth resistor R25, a fifth capacitor C5, a sixth capacitor C6, and a seventh capacitor C7.

[0082] The second logic operation chip H1 has a first pin connected to the control module 1 through the VIN network and a fifth pin connected to the control module 1 through the VOUT network.

[0083] A first end of the twelfth resistor R12 is connected to the VIN network, and a second end thereof is connected to the second pin of the second logic operation chip H1 .

[0084] A first end of the thirteenth resistor R13 is connected to the VIN network, and a second end thereof is connected to the third pin of the second logic operation chip H1 .

[0085] A first end of a fourteenth resistor R14 is connected to the VIN network, and a second end is connected to the fourth pin of the second logic operation chip H1;

[0086] A first end of the fifteenth resistor R15 is connected to the power supply VCC.

[0087] A first terminal of the sixteenth resistor R16 is grounded.

[0088] The first amplifier U2.2 has a non-inverting input connected to the second end of the fifteenth resistor R15 and the second end of the sixteenth resistor R16, and an inverting input connected to the control module 1 via the VIN network. In this embodiment, the first amplifier U2.2 is an AD8606 RF low noise amplifier.

[0089] A first end of the seventeenth resistor R17 is connected to the power supply VCC.

[0090] A first terminal of the eighteenth resistor R18 is grounded.

[0091] The second amplifier U2.1 has a positive power supply terminal connected to power supply VCC, a negative power supply terminal connected to ground, an inverting input terminal and an output terminal connected to the VOUT network, and a non-inverting input terminal connected to the second terminal of resistor R17 and the second terminal of resistor R18, respectively. In this embodiment, the second amplifier U2.2 is an AD8606 RF low-noise amplifier.

[0092] A first end of the nineteenth resistor R19 is connected to the inverting input end of the first amplifier U2.2, and a second end thereof is connected to the output end of the first amplifier U2.2.

[0093] A first end of the twentieth resistor R20 is connected to the output end of the first amplifier U2.2.

[0094] A first end of the twenty-first resistor R21 is connected to a second end of the twentieth resistor R20 .

[0095] A first end of the fourth capacitor C4 is connected to the non-inverting input end of the second amplifier U2.1.

[0096] The fourth pin of the third logic operation chip U3 is connected to the second end of the 21st resistor R21, the fifth pin is connected to the second end of the 20th resistor R20, the sixth pin is connected to the second end of the fourth capacitor C4, the tenth and eleventh pins are connected to the power supply VCC, the thirteenth and fourteenth pins are grounded, the fifteenth pin is connected to the control module 1 via the I2C1SCL network, and the sixteenth pin is connected to the control module 1 via the I2C1SDA network. In this embodiment, the third logic operation chip U3 is an AD5933 chip.

[0097] A first end of the twenty-second resistor R22 is connected to the power supply VCC, and a second end is connected to the control module 1 via the I2C1SCL network;

[0098] A first end of the twenty-third resistor R23 is connected to the twelfth pin of the third logic operation chip U3 , and a second end thereof is grounded.

[0099] A first end of the twenty-fourth resistor R24 ​​is connected to the ninth pin of the third logic operation chip U3 , and a second end thereof is connected to the power supply VCC.

[0100] A first end of the twenty-fifth resistor R25 is connected to the power supply VCC, and a second end thereof is connected to the control module 1 via the I2C1SDA network.

[0101] A first end of the fifth capacitor C5 is connected to the ninth pin of the third logic operation chip U3 , and a second end thereof is grounded.

[0102] A first end of the sixth capacitor C6 is connected to the second end of the twenty-fourth resistor R24 ​​, and a second end thereof is grounded.

[0103] A first end of the seventh capacitor C7 is connected to the second end of the twenty-fourth resistor R24 ​​, and a second end thereof is grounded.

[0104] The third logic chip U3 generates an excitation signal at a set frequency, which is filtered by the fourth capacitor C4 and then applied to the VCC power supply divided by R17 and R18. This new signal is then applied to the human skin. The resulting signal is then collected from the skin, amplified by the first amplifier U2.2, and input into the third logic chip U3 for processing. This data is then stored in registers within the third logic chip U3. This data is then communicated with the control module 1 via I2C1SDA and I2C1SCL, transmitting the real and imaginary impedance values. Finally, the final skin resistance value is determined by the algorithm within the control module 1.

[0105] The impedance detection module 5 obtains skin impedance information, amplifies and filters the skin impedance information, converts the A / D into the real and imaginary impedance parts, and obtains the actual impedance through the following formula and transmits it to the control module 1:

[0106] Z=1 / (G*A)

[0107] Where Z is the actual measured impedance, G is the gain proportional coefficient, and A is the impedance amplitude;

[0108]

[0109] Where Re is the real part of impedance and Im is the imaginary part of impedance.

[0110] The electrode connection module 3 is connected to the electrical stimulation output module 2 for transmitting electrical stimulation current and is also used to isolate the output of the electrical stimulation output module 2 from interfering with the impedance detection module 1 .

[0111] Figure 4 FIG. 4 is a circuit diagram of a circuit connection module in an embodiment of the present invention.

[0112] like Figure 4 As shown, the electrode connection module includes: a first connector CN1, a second connector CN2, a third connector CN3, a fourth logic operation chip U4, a fifth logic operation chip U5, an eighth capacitor C8, a ninth capacitor C9, a twenty-sixth resistor R26, a tenth capacitor C10, a twenty-seventh resistor R27, and an eleventh capacitor C11.

[0113] The fourth pin of the second connector CN2 is connected to the control module 1 through the 2A2 network, the fifth pin is connected to the control module 1 through the 2A2 network, the sixth pin is connected to the control module 1 through the 2A1 network, and the seventh pin is connected to the control module 1 through the 2A1 network.

[0114] The fourth pin of the third connector CN3 is connected to the control module 1 through the 1A2 network, the fifth pin is connected to the control module 1 through the 1A2 network, the sixth pin is connected to the control module 1 through the 1A1 network, and the seventh pin is connected to the control module 1 through the 1A1 network.

[0115] The first pin of the fourth logic operation chip U4 is connected to the control module 1 via the VINEN network. The second pin is connected to the power supply VCC. The third pin is grounded. The fourth pin is respectively connected to the sixth and seventh pins of the first connector CN1. In this embodiment, the fourth logic operation chip U4 is an ADG839YKSZ chip.

[0116] The first pin of the fifth logic operation chip U5 is connected to the control module 1 through the VOUTEN network, the second pin is connected to the power supply VCC, the third pin is grounded, the fourth pin is connected to the fourth pin and the fifth pin of the first connector CN1 respectively, and the fifth pin is connected to the control module 1 through the VOUT network. In this embodiment, the fifth logic operation chip U5 is an ADG839YKSZ chip

[0117] A first end of the eighth capacitor C8 is connected to the second pin of the fifth logic operation chip U5 , and a second end thereof is grounded.

[0118] A first end of the ninth capacitor C9 is connected to the second pin of the fifth logic operation chip U4 , and a second end thereof is grounded.

[0119] A first end of the twenty-sixth resistor R26 is connected to the fifth pin of the fifth logic operation chip U5 , and a second end thereof is grounded.

[0120] A first end of the tenth capacitor C10 is connected to the first end of the twenty-sixth resistor R26 , and a second end thereof is grounded.

[0121] A first end of the twenty-seventh resistor R27 is connected to the fifth pin of the fourth logic operation chip U4 , and a second end thereof is grounded.

[0122] The eleventh capacitor C11 has a first end connected to the first end of the twenty-seventh resistor R27 , and a second end grounded.

[0123] When the VINEN pin input of control module 1 is high, the switch between the fourth and fifth pins of the fourth logic chip U4 is closed, which is equivalent to connecting VIN to the first connector CN1. When VINEN is low, VIN is disconnected from the first connector CN1. Therefore, the connection between VIN and VOUT and the first connector CN1 is controlled by control module 1.

[0124] Figure 5 This is a flow chart of a multi-channel electrical stimulation device based on skin impedance in an embodiment of the present invention.

[0125] like Figure 5 As shown, in step 501, firstly, the parameters of each module are initialized.

[0126] Step 502: output fixed electrical stimulation according to initial parameters.

[0127] In step 503 , the control module 1 determines whether an external control signal and a skin impedance signal are received. If so, step 507 is executed to adjust the initial parameters according to the control signal.

[0128] If not, then execute step 504 and perform impedance detection every 300 seconds;

[0129] Step 505 , when the stimulation frequency is set to alternate between 2 Hz and 100 Hz, if yes, then execute step 506 to select the optimal parameters according to the random forest model; if no, then execute step 502 .

[0130] A random forest model was used to predict the change in skin impedance signal based on treatment intensity and pulse width. The combination that resulted in the greatest impedance reduction was selected and an electrical stimulus was output. When establishing the forest model, data was collected from the device of the present invention to reduce errors. The subject's impedance at the start of treatment (Z0), the initial treatment intensity (V0), the initial treatment pulse width (W0), and the skin impedance (Z1) five minutes after treatment were recorded. The treatment frequency was alternating between 2Hz and 100Hz. Data preprocessing and model training were performed in a Python environment. The collected data set was divided into a training set and a validation set in a 7:3 ratio. The data was read and outliers were filtered out. A data structure was constructed with [Z0, V1, W1] as input features and ΔZ = Z1 - Z0 as output labels. A CART decision tree algorithm was used to establish an impedance change prediction model. The trained prediction model was converted into C language code executable by an STM32 microcontroller and burned into the chip's memory area.

[0131] Get the current user's skin impedance value Z t , perform the following operations: generate a set of pulse intensity-width combinations {V a ,W a Substitute each combination into the prediction model to calculate the expected impedance change ΔZ a ; Select ΔZ a The smallest optimal parameter pair (V o ,W o ); applying selected electrical stimulation parameters through the electrical stimulation output module 2.

[0132] The multi-channel electrical stimulation device based on skin impedance provided in this embodiment further includes:

[0133] The emergency stop module is connected to the electrical stimulation output module 2 and is used to close the channel of the electrical stimulation output module 2 so that the electrical stimulation input module 2 stops outputting current.

[0134] The display module is connected to the control module 1 and is used to display the working status of each module.

[0135] The power supply module is connected to the control module 1, the electrical stimulation output module 2, and the electrical impedance detection module 5 respectively, and is used to convert the battery voltage into a target voltage to supply power to each module and manage the battery charging.

[0136] Control module 1 controls channel enable unit 21, boost unit 22 outputs a stable voltage, which is subsequently processed by polarity conversion unit 23 to generate multiple bipolar electrical stimulation pulse currents. These are then applied to the human body via electrode connection module 4 and electrode module 5, achieving multi-channel transcutaneous electrical nerve stimulation, improving the efficiency of the electrical stimulation circuit and reducing the potential harm to the human body caused by charge accumulation. Simultaneously, electrode module 5 is connected to impedance detection module 3 via electrode connection module 4, and ultimately transmitted to control module 1 for corresponding calculations. This enables the collection of information related to human skin impedance, which is then used as the basis for closed-loop control to adjust the electrical stimulation parameters.

[0137] Functions and Effects of the Embodiments

[0138] The multi-channel electrical stimulation device based on skin impedance provided in this embodiment includes: a control module for receiving an external control signal and a skin impedance signal and outputting an internal control signal based on the received signal; an electrical stimulation output module connected to the control module for outputting an electrical stimulation current corresponding to the control signal; an electrode connection module connected to the electrical stimulation output module for transmitting the electrical stimulation current; an electrode module connected to the electrode connection module for outputting the electrical stimulation current to the skin and transmitting the collected skin impedance information to the electrode connection module; an impedance detection module connected to the electrode connection module and the control module, respectively, for converting the skin impedance information transmitted by the electrode connection module into a skin impedance signal and transmitting it to the control module for updating the skin impedance signal of the control module; wherein the internal control signal includes a conduction control signal, an amplitude control signal, and a polarity control signal, wherein the polarity control signal includes a frequency control signal and a pulse width control signal; and the electrode connection module is further used to isolate the output of the electrical stimulation output module from interfering with the impedance detection module. Therefore, the multi-channel electrical stimulation device based on skin impedance of the present invention applies electrical stimulation current to the skin through multiple channels and collects skin impedance, and then optimizes the electrical stimulation parameters based on the measured skin impedance to achieve precise treatment.

[0139] This embodiment also provides an active adjustment mode and an intelligent adjustment mode, and selects the most appropriate mode for treatment according to different situations.

[0140] This embodiment also uses a random forest model based on the skin impedance signal to traverse the treatment intensity and pulse width, and predict the parameter combination that can cause the best change in the skin impedance signal, thereby achieving precise control.

[0141] This embodiment also controls the conduction state of the channel, the amplitude of the electrical stimulation current, and the type of the electrical stimulation current through different units.

[0142] This embodiment also uses the emergency stop module to stop the electrical stimulation input module from outputting current.

[0143] This embodiment also displays the working status of each module in the multi-channel electrical stimulation device based on skin impedance through a display module.

[0144] This embodiment also converts the battery voltage into a target voltage through the power module to supply power to each module of the multi-channel electrical stimulation device based on skin impedance and charges the battery.

[0145] Those skilled in the art will appreciate that the present invention is not limited to the foregoing embodiments. The foregoing embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A multi-channel electrical stimulation device based on skin impedance, characterized in that: include: a control module, configured to receive an external control signal and a skin impedance signal and output an internal control signal according to the received signals; an electrical stimulation output module, connected to the control module, and configured to output a corresponding electrical stimulation current according to the internal control signal; an electrode connection module, connected to the electrical stimulation output module, and configured to transmit the electrical stimulation current; an electrode module, connected to the electrode connection module, for outputting the electrical stimulation current to the skin and transmitting the collected skin impedance information to the electrode connection module; an impedance detection module, connected to the electrode connection module and the control module, respectively, for converting the skin impedance information transmitted by the electrode connection module into a skin impedance signal and transmitting the signal to the control module for updating the skin impedance signal of the control module; Among them, the internal control signal includes: a conduction control signal, an amplitude control signal and a polarity control signal, wherein the polarity control signal includes a frequency control signal and a pulse width control signal; the electrode connection module is also used to isolate the output of the electrical stimulation output module from interfering with the impedance detection module.

2. The multi-channel electrical stimulation device based on skin impedance according to claim 1, Its characteristics are: Wherein, the control module is configured as: active adjustment mode and intelligent adjustment mode; In the active adjustment mode, the corresponding stimulation parameters are adjusted based on the input parameter control signal; In the intelligent adjustment mode, stimulation is performed alternately at frequencies of 2 Hz and 100 Hz, with each frequency lasting 10 seconds, and the human skin impedance is detected every five minutes. This is used as input to predict the optimal treatment frequency and pulse width, and the input is transmitted to the control module for parameter implementation.

3. The multi-channel electrical stimulation device based on skin impedance according to claim 1, characterized in that: in, The control module also uses a random forest model to traverse the treatment intensity and pulse width based on the skin impedance signal to predict the parameter combination that can cause the skin impedance signal to produce the best change.

4. The multi-channel electrical stimulation device based on skin impedance according to claim 1, Its characteristics are: Wherein, the electrical stimulation output module includes: a channel enabling unit, connected to the control module, for adjusting the conduction state of the channel according to the conduction control signal; a boost unit, connected to the control module, and configured to adjust the amplitude of the electrical stimulation current according to the amplitude control signal; The polarity conversion unit is connected to the control module and is used to convert the type of the electrical stimulation current from a continuous current to a bipolar pulse current according to the polarity control signal, and to control the output frequency and pulse width.

5. The multi-channel electrical stimulation device based on skin impedance according to claim 4, characterized in that: The channel enabling unit includes: a first resistor, a first end of which is connected to the control module via the EN1 network; A first MOSFET tube, wherein the gate of the first MOSFET tube is connected to the second end of the first resistor, the source is connected to the power supply VCC, and the drain is connected to the boost unit.

6. The multi-channel electrical stimulation device based on skin impedance according to claim 4, characterized in that: The boost unit comprises: a first capacitor, a first end of which is connected to the control module via a PWM1 network; a first logic operation chip, wherein the first pin and the eighth pin of the first logic operation chip are both connected to the power supply VCC, the second pin is connected to the second end of the first capacitor, the third pin, the fifth pin, and the sixth pin are all unconnected, and the fourth pin is grounded; a second resistor, a first end of which is grounded and a second end of which is connected to the second pin; a second capacitor, a first end of which is grounded; a first inductor connected to the second end of the second capacitor; a first transistor, wherein the collector of the first transistor is connected to the second end of the first inductor, and the emitter is grounded; a third resistor, a first end of which is connected to the seventh pin of the first logic operation chip, and a second end of which is connected to the base of the first transistor; a first diode having a first end connected to the second end of the first inductor; a fourth resistor, a first end of which is connected to the second end of the first diode; a fifth resistor, having a first end connected to the second end of the fourth resistor and a second end grounded; A third capacitor has a first end connected to the second end of the first diode and a second end grounded.

7. The multi-channel electrical stimulation device based on skin impedance according to claim 4, characterized in that: The polarity conversion unit includes: a sixth resistor, a first end of which is connected to the control module via the CON1 network; a second triode, wherein the base of the second triode is connected to the second end of the sixth resistor and the emitter is grounded; a seventh resistor, having a first end connected to the second end of the first diode, and a second end connected to the collector of the second transistor; a third triode, wherein the base of the third triode is connected to the collector of the second triode, and the collector is connected to the second end of the seventh resistor; an eighth resistor, a first end of which is connected to the emitter of the third transistor, and a second end of which is connected to the control module via a 1A1 network; a fourth triode, having an emitter connected to the second end of the eighth resistor, a base connected to the collector of the second triode, and a collector grounded; a ninth resistor, a first end of which is connected to the first end of the seventh resistor; a fifth triode, a collector of which is connected to the first end of the seventh resistor; a tenth resistor, a first end of which is connected to the control module via a CON2 network; a sixth transistor, having a collector connected to the second end of the ninth resistor and the base of the fifth transistor respectively, a base connected to the second end of the tenth resistor, and an emitter grounded; an eleventh resistor, a first end of which is connected to the emitter of the fifth transistor, and a second end of which is connected to the control module via the 1A2 network; The seventh transistor has an emitter connected to the second end of the eleventh resistor, a base connected to the collector of the sixth transistor, and a collector grounded.

8. The multi-channel electrical stimulation device based on skin impedance according to claim 1, characterized in that: in, The impedance detection module includes: A second logic operation chip, wherein the first pin is connected to the control module via the VIN network and the fifth pin is connected to the control module via the VOUT network; a twelfth resistor, a first end of which is connected to the VIN network, and a second end of which is connected to the second pin of the second logic operation chip; a thirteenth resistor, a first end of which is connected to the VIN network, and a second end of which is connected to the third pin of the second logic operation chip; a fourteenth resistor, a first end of which is connected to the VIN network, and a second end of which is connected to the fourth pin of the second logic operation chip; A fifteenth resistor, a first end of which is connected to a power supply VCC; a sixteenth resistor, a first end of which is grounded; a first amplifier, wherein a non-inverting input terminal is connected to the second end of the fifteenth resistor and the second end of the sixteenth resistor respectively, and an inverting input terminal is connected to the control module via a VIN network; A seventeenth resistor, a first end of which is connected to a power supply VCC; an eighteenth resistor, a first end of which is grounded; a second amplifier, having a positive power supply terminal connected to the power supply VCC, a negative power supply terminal grounded, an inverting input terminal and an output terminal both connected to the VOUT network, and a non-inverting input terminal connected to the second terminal of the seventeenth resistor and the second terminal of the eighteenth resistor respectively; A first end of a nineteenth resistor is connected to the inverting input terminal of the first amplifier, and a second end thereof is connected to the output terminal of the first amplifier; a twentieth resistor, a first end of which is connected to the output end of the first amplifier; a twenty-first resistor, a first end of which is connected to the second end of the twenty-first resistor; a fourth capacitor, a first end of which is connected to the non-inverting input terminal of the second amplifier; a third logic operation chip, a fourth pin connected to the second end of the twenty-first resistor, a fifth pin connected to the second end of the twenty-second resistor, a sixth pin connected to the second end of the fourth capacitor, a tenth pin and an eleventh pin connected to a power supply VCC, a thirteenth pin and a fourteenth pin connected to ground, a fifteenth pin connected to the control module via an I2C1SCL network, and a sixteenth pin connected to the control module via an I2C1SDA network; A twenty-second resistor, a first end of which is connected to the power supply VCC, and a second end of which is connected to the control module via an I2C1SCL network; A twenty-third resistor, having a first end connected to the twelfth pin of the third logic operation chip and a second end grounded; A twenty-fourth resistor, having a first end connected to the ninth pin of the third logic operation chip and a second end connected to a power supply VCC; A twenty-fifth resistor, a first end of which is connected to the power supply VCC, and a second end of which is connected to the control module via the I2C1SDA network; a fifth capacitor, a first end of which is connected to the ninth pin of the third logic operation chip, and a second end of which is grounded; a sixth capacitor, having a first end connected to the second end of the twenty-fourth resistor and a second end grounded; A seventh capacitor has a first end connected to the second end of the twenty-fourth resistor and a second end grounded.

9. The multi-channel electrical stimulation device based on skin impedance according to claim 1, characterized in that: in, The impedance detection module obtains the skin impedance information, amplifies and filters the skin impedance information, performs AD conversion on the real impedance part and the imaginary impedance part, and obtains the actual impedance through the following formula and transmits it to the control module: Z=1 / (G*A) Where Z is the actual measured impedance, G is the gain proportional coefficient, and A is the impedance amplitude; Where Re is the real part of impedance and Im is the imaginary part of impedance.

10. The multi-channel electrical stimulation device based on skin impedance according to claim 1, characterized in that: Also includes: The emergency stop module is connected to the electrical stimulation output module and is used to close the channel of the electrical stimulation output module to stop the electrical stimulation input module from outputting current. The display module is connected to the control module and is used to display the working status of each module. The power supply module is respectively connected to the control module, the electrical stimulation output module and the impedance detection module, and is used to convert the battery voltage into a target voltage to supply power to each module and manage the battery charging.

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