Color-changeable nicotine bag body and nicotine bag

Abstract

The invention relates to the technical field of tobacco manufacturing, in particular to a nicotine bag body which comprises a bag body outer face and a bag body inner face, the bag body outer face contains a color-changing coating made of color-changing materials, and when the color-changing materials make contact with saliva, the color-changing coating changes color. Whether the nicotine bag is used by other people or not is visually judged by setting a chromogenic reaction mechanism, so that the nicotine bag which is in contact with the oral cavity of other people is prevented from being eaten by mistake, and the risk of cross infection of pathogens is reduced; discoloration is carried out according to discoloration of an acid-base indicator and enzymatic reaction of an enzyme response type material, and a natural material or a material safe to a human body is preferably selected; the invention further discloses a color-changeable nicotine bag. The nicotine bag comprises a nicotine bag body and a buccal material.

Description

Technical Field

[0001] This patent relates to the field of tobacco manufacturing technology, and specifically to a color-changing nicotine bag body and a nicotine bag. Background Art

[0002] Nicotine pouches are small, white bags pre-filled with food-grade nicotine. They are small, oral products placed between the lips and gums. The nicotine and auxiliary ingredients inside are absorbed through the oral mucosa through slow osmosis, rather than rapidly escaping in large quantities. Nicotine pouches do not contain tobacco. They are typically made by mixing nicotine base, nicotine salts, or nicotine complexes / adsorbents with fillers, dispersants, lubricants, sweeteners, flavorings, pH regulators, adhesives, and other materials to form granules, which are then packaged in a small, non-woven fabric pouch. Unlike traditional tobacco products such as cigarettes or chewing tobacco, nicotine pouches do not require burning or exhaling, and there is no need to inhale smoke or expose the lungs to harmful chemicals such as tar or carbon monoxide.

[0003] A significant issue with nicotine pouches currently on the market is the difficulty in visually determining whether they have been used. Nicotine pouches are typically placed between the user's lips and gums during use, leaving no visible signs of liquid residue, stains, or color changes on the pouch surface. This makes it difficult to visually determine whether the pouch has been used.

[0004] Existing nicotine pouches lack a mechanism for changing color in the presence of saliva, resulting in no discernible difference in appearance before and after use. This makes it difficult for consumers to visually determine whether a nicotine pouch has been used by someone else. Without the ability to determine the pouch's previous use, consumers are at high risk of accidentally ingesting a nicotine pouch that has come into contact with someone else's mouth, increasing the risk of cross-infection of pathogens and posing a threat to their health.

[0005] Therefore, there is a need for a nicotine pouch product that changes color when exposed to saliva. Through the color change characteristic of the product after contact with saliva, consumers can easily and quickly determine whether the nicotine pouch has been used, thereby solving the problem of existing nicotine pouch products that are difficult to determine the usage status. Summary of the Invention

[0006] The purpose of this patent is to provide a nicotine pouch product that changes color when exposed to saliva. By virtue of the color change characteristic of the product upon contact with saliva, consumers can easily and quickly determine whether the nicotine pouch has been used, thereby resolving the problem of existing nicotine pouch products being difficult to determine the usage status. This patent provides the following technical solutions:

[0007] A first aspect: provides a color-changing nicotine bag, which includes an outer bag surface and an inner bag surface. The outer bag surface includes a color-changing coating containing a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating changes color.

[0008] Furthermore, the color-changing material includes an acid-base indicator, and the acid-base indicator changes color according to the pH value in the saliva.

[0009] Furthermore, the acid-base indicator includes a synthetic food colorant or a natural pH indicator; the synthetic food colorant includes allura red; the natural pH indicator includes purple cabbage extract, blueberry extract, turmeric extract or red cabbage extract.

[0010] Furthermore, the color-changing material includes an enzyme-responsive color-changing material, which undergoes an enzymatic reaction based on enzymes in saliva.

[0011] Furthermore, the enzyme includes amylase; and the enzyme-responsive color-changing material includes an iodine reagent.

[0012] Furthermore, the nicotine bag is made of natural fiber, thermoplastic polymer or cellulose.

[0013] A second aspect: provides a color-changing nicotine bag, the nicotine bag comprising the above-mentioned nicotine bag body and an oral material contained in the nicotine bag body.

[0014] Furthermore, the oral material includes nicotine and additives, and the additives include flavorings, sweeteners, moisturizers, pH regulators, fillers and plant fibers.

[0015] This patent has the following beneficial effects:

[0016] 1. This patent discloses a nicotine bag, which includes an outer bag body and an inner bag body. The outer bag body contains a color-changing coating made of a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating changes color. By setting a color reaction mechanism, it is intuitively determined whether the nicotine bag has been used by others, thereby preventing accidental ingestion of nicotine bags that have come into contact with the mouth of others and reducing the risk of cross-infection of pathogens.

[0017] 2. The color change reaction is based on the enzymatic reaction mechanism of the acid-base indicator color change reaction enzyme responsive material, and natural materials or materials safe for the human body are preferred.

[0018] The products described herein are configured for oral use. As used herein, the term "configured for oral use" means that during use of the product, saliva in the user's mouth causes one or more components of the product (e.g., flavorings and / or buccal materials) to enter the user's mouth. In certain embodiments, the product is adapted to deliver the component to the user through mucous membranes in the user's mouth, the user's digestive system, or both, and in some cases, the component is an orally deliverable content that can be absorbed through the mucous membranes in the mouth or absorbed through the digestive tract when the product is used.

[0019] In some embodiments, a product is provided that contains a mixture of one or more components of a nicotine pouch. Such a nicotine pouch is typically used by placing the nicotine pouch containing the mixture in the user's mouth. Typically, the nicotine pouch is placed somewhere in the user's mouth, such as beneath the lips. The pouch is preferably not chewed or swallowed. Exposure to saliva then allows some of the flavoring and / or nicotine components of the mixture to pass through the water-permeable nicotine pouch, providing the user with flavor and satisfaction, without the user needing to spit out any portion of the mixture. After 10 to 60 minutes of use, a substantial amount of the mixture has been ingested, and the nicotine pouch can be removed from the mouth and discarded.

[0020] Nicotine pouches may be provided as individual pouches or multiple pouches connected together in an end-to-end arrangement.

[0021] Exemplary nicotine pouches can be made of bag material, and in such a way that during use by the user, the nicotine pouch experiences controlled dispersion or dissolution. This bag material can have forms such as a net, a screen, perforated paper, a permeable fabric, etc. For example, the nicotine pouch material made of rice paper in a mesh form or perforated rice paper may dissolve in the user's mouth. Under normal use conditions, the bag and the mixture can each experience complete dispersion in the oral cavity of the user, so that both the bag and the mixture can be taken in by the user. Other examples of the bag material can use water-dispersible film-forming materials (for example, adhesives, such as alginate, carboxymethyl cellulose, xanthan gum, pullulan, etc.) and those materials combined with materials such as ground cellulose (for example, fine particle size pulp) to manufacture. Preferred nicotine pouch materials, although water-dispersible or soluble, can be designed and manufactured so that under normal use conditions, before the nicotine pouch experiences the loss of its physical integrity, a large amount of mixture contents penetrate through the delivery pouch material. If desired, flavoring ingredients, disintegration aids, and other desired components may be incorporated into or applied to the pouch material.

[0022] The term "nonwoven" is used herein to refer to a fibrous material, web, mat, batt or sheet in which the fibers are arranged in an uncertain or random orientation. In one embodiment, the nonwoven fibers initially exist in the form of continuous, unbound fibers or filaments. The continuous fibers are arranged substantially parallel to each other in at least one direction. In certain embodiments, a first plurality of continuous fibers are arranged substantially parallel to each other in a first direction, and a second plurality of continuous fibers are arranged substantially parallel to each other in a transverse direction relative to the first plurality of continuous fibers. The manufacturing method of such a nonwoven generally includes bonding various fibers or filaments together. The bonding method of the fibers or filaments can vary, including heat, machinery and chemical techniques selected based on the desired properties of the final product. In some embodiments, the oriented fibers undergo a heat treatment process (e.g., a lamination process) to bond them together. Due to the limited orientation of the continuous fibers, the overlap of each fiber is low, and a thin nonwoven can be achieved. The surface of the nonwoven can also be uniform and smooth.

[0023] In some embodiments, nonwoven fabrics can be manufactured in a spun-to-web or melt-spinning process, which includes spunbonding and meltblowing processes, wherein such processes are understood to generally require melting, extruding, collecting and bonding thermoplastic polymer materials to form a fiber nonwoven web. Fiber can be spun and then directly dispersed into a web by a deflector. Spunbonding generally includes melt spinning, in which polymer melts into a liquid state and is forced to enter cold air through a small hole so that the polymer strands solidify according to the shape of the hole. The fiber bundle thus produced is then mechanically stretched so that the fibers are oriented. The nonwoven web is then formed by depositing the drawn fibers onto a moving belt.

[0024] Meltblowing is a process in which a polymer (or multiple polymers) is melted into a liquid state and extruded through a linear die containing many small holes. As the polymer is extruded, a stream of hot air is first blown onto the polymer, first stretching and / or attenuating the extruded polymer stream to form extremely fine filaments. The air stream typically stretches or attenuates the molten polymer by many orders of magnitude. The stretched polymer fibers are collected as a randomly entangled, self-bonded nonwoven web.

[0025] In some embodiments, the nonwoven web can be made in a process that combines orientation and spinning techniques. The nonwoven web can be formed by spinning continuous filament fibers, orienting the fibers parallel to each other in at least one direction, and thermally bonding the fibers. In various embodiments, the nonwoven web can be multilayered, with multiple layers laminated in more than one direction.

[0026] In thermal bonding embodiments, the nonwoven fabric can be formed using a thermoplastic polymer as the binder fiber. The thermoplastic polymer can exhibit a relatively low melting point to facilitate heat sealing of the bag material. For example, the thermoplastic polymer fiber can generally have a melting point of about 120° C. to 200° C. Exemplary thermoplastic polymers include various polyolefins and polyester materials.

[0027] In certain embodiments, the nonwoven fabric may include additional fiber types blended with the above-mentioned thermoplastic polymer fibers. Suitable fibers include those made from packaging layers, cotton, regenerated cellulose, cellulose acetate, cellulose triacetate, cellulose nitrate, ethyl cellulose, cellulose acetate propionate, cellulose acetate butyrate, hydroxypropyl cellulose, methylhydroxypropyl cellulose, protein fibers, and the like.

[0028] In some embodiments, the material of the nicotine bag is selected from one of non-woven fabrics, polylactic acid, cotton, linen, bamboo fiber, wood pulp cellulose, polyethylene, polypropylene, polyester fiber, silk, alginate, and starch.

[0029] The fibers used in the nonwoven fabrics according to the present disclosure can vary and include fibers having any type of cross-section, including but not limited to round, rectangular, square, oval, triangular, and multilobal. In certain embodiments, the fibers can have one or more void spaces, wherein the void spaces can have, for example, a round, rectangular, square, oval, triangular, or multilobal cross-section.

[0030] The physical parameters of the fibers present in the nonwoven fabric can vary. For example, the fibers used in the nonwoven fabric can have different sizes and curl characteristics. In some embodiments, the fibers used in the nonwoven fabric can be nanofibers, submicron fibers, and / or micron-sized fibers. In certain embodiments, the fibers used in the present invention measure 1.5 to 1.90 dpf.

[0031] The methods for producing nonwoven fabrics can be varied, and the formation of the web can be accomplished by any method known in the art.

[0032] The nonwoven web can be produced by a spunbond process and / or a meltblown process and can have varying thickness, porosity, and other parameters. The nonwoven web can be formed so that the fiber orientation and porosity of the bagged product formed therefrom can maintain the composition enclosed within the bag in some embodiments, but can also allow the consumer to enjoy the components of the composition.

[0033] In some embodiments, the nonwoven fabric comprises nanocellulose, and the nanocellulose in the nicotine pouch comprises cellulose nanofibrils having a diameter and a length, wherein the diameter is about 1 to 100 nm and the length is about 1 to 10 microns, and the amount of nanocellulose present in the nicotine pouch can vary.

[0034] In some embodiments, by combining two or more layers of fleece material, various beneficial properties can be exhibited by the resulting bag-like product.The layered structure of the disclosed bag can be provided, for example, by independently providing two fabrics and combining them such that the two fabrics are in contact with each other.

[0035] In some embodiments, the multilayer packaging layer is provided by the lamination of two or more layers, and namely the bagged product comprises the bag comprising the laminated multilayer material.Lamination is generally related to bonding two or more layers by applying heat and pressure.Those skilled in the art will recognize that the suitable laminate of any two or more nonwoven layers as provided herein is to produce the required necessary temperature and pressure of the multilayer bag material.

[0036] In some embodiments, the multilayer packaging layer is provided by attaching two or more packaging layers together using an adhesive or stitching. In the case where the multilayer fiber web comprises a wet-laid material, multiple headboxes can be used to connect the layers together. In some embodiments, the multilayer packaging layer is provided by needling two or more layers. In certain embodiments, the laminate structure is prepared using needling and then extruded. In some embodiments, the oral material can be laminated to the laminate structure before needling, and the oral material can be distributed throughout the resulting bagged product.

[0037] The nicotine pouch of the present disclosure may be soluble. As used herein, the term "soluble" refers to a composition having a water-soluble component that interacts with the moisture in the oral cavity and enters a solution, thereby causing the product to be gradually consumed. A soluble product can last for a given period of time in the user's oral cavity until it is completely dissolved. The dissolution rate can vary over a wide range, from about 1 minute to about 60 minutes. For example, the first release composition typically dissolves and / or releases the active substance within about 2 minutes, typically about 1 minute. Dissolution can occur by any means, such as melting, mechanical destruction (e.g., chewing), enzymatic or other chemical degradation, or by interactions between components that destroy the composition.

[0038] The amount of the composition contained in each pouch can vary. In some embodiments, the weight of the composition in each pouch is at least about 50 mg. In some smaller embodiments, the weight of the composition in each pouch can be from about 100 to about 300 mg. For larger embodiments, the weight of the composition in each pouch can be from about 300 mg to about 700 mg. If desired, other components can be accommodated in each pouch. For example, at least one flavored water-dispersible or water-soluble material band, sheet or piece can be provided in each pouch with or without at least one capsule. Such bands or sheets can be folded or wrinkled so as to be easily incorporated into the bag.

[0039] Oral materials

[0040] In some embodiments, the oral material comprises a nicotine component. "Nicotine component" refers to any suitable form of nicotine for providing oral absorption of at least a portion of the nicotine, for example, nicotine includes nicotine and nicotine derivatives, specifically including: free base nicotine, nicotine salts, nicotine in a matrix such as a sugar matrix or an organometallic complex, nicotine-ion exchange resin combinations, nicotine inclusion complexes, and non-covalently bound nicotine, wherein the non-covalently bound nicotine includes nicotine lactate, nicotine malate, nicotine salicylate, nicotine cyclodextrin inclusion complexes, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, and nicotine benzoate.

[0041] Typically, the nicotine component is selected from nicotine free base and nicotine salts. In some embodiments, the nicotine component is nicotine in its free base form, which can be readily adsorbed into, for example, a microcrystalline cellulose material to form a microcrystalline cellulose-nicotine carrier complex. See, for example, U.S. Patent Publication No. 2004 / 0191322 to Hansson for a discussion of nicotine in its free base form, which is incorporated herein by reference.

[0042] In some embodiments, at least a portion of the nicotine component may be used in the form of a salt.

[0043] In some embodiments, at least a portion of the nicotine can be in the form of a resin complex of nicotine, wherein the nicotine is bound to an ion exchange resin, such as a nicotine ion exchange resin.

[0044] Typically, the nicotine component (calculated as free base), when present, is present at a concentration of at least about 0.001% by weight of the composition, for example, from about 0.001% to about 10%. In some embodiments, the nicotine component is present at a concentration of from about 0.1% w / w to about 10% by weight, calculated as free base and based on the total weight of the composition. In some embodiments, the nicotine component is present at a concentration of from about 0.1% wt to about 3% wt, calculated as free base and based on the total weight of the composition.

[0045] Additional ingredients

[0046] Representative types of additional ingredients that may comprise the compositions disclosed herein or that may be used to manufacture the bagged products disclosed herein include fillers, thickeners, film formers, binders, buffers and pH control agents, anti-adherents, glidants, sweeteners, wetting agents, preservatives and antioxidants, surfactants, colorants, lubricants, and processing aids. In some embodiments, the compositions comprise additional components such as fillers, binders, wetting agents, sweeteners, salts, buffers, and the like.

[0047] In some embodiments, the plant fiber comprises water-insoluble fiber selected from wheat fiber, pea fiber, rice fiber, corn fiber, oat fiber, tomato fiber, barley fiber, rye fiber, beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, and powdered cellulose.

[0048] In some embodiments, the pH adjuster is selected from acetic acid, adipic acid, citric acid, fumaric acid, glucono-delta-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentapotassium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, and magnesium oxide.

[0049] In some embodiments, sweeteners include aspartame, acesulfame potassium, cyclamate, saccharin, saccharin sodium, sucralose, neotame, sodium cyclamate, stevia, licorice, disodium glycyrrhizate, tripotassium and trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, corn syrup, starch sugar and lactose, sorbitol, maltitol, isomalt, palatinitol, xylitol, lactitol, mannitol, erythritol, and dextran. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] In order to more clearly illustrate the technical solutions of the embodiments of this patent, the following is a brief introduction to the drawings required for use in the embodiments. It should be understood that the following drawings only show certain embodiments of this patent and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without creative work.

[0051] Figure 1 This is a schematic diagram of the three-dimensional structure of the nicotine bag in Example 1;

[0052] Figure 2 This is a schematic diagram of the three-dimensional structure of the nicotine bag after the color development reaction in Example 1.

[0053] The description of the accompanying drawings is as follows:

[0054] 10: Nicotine bag body;

[0055] 11: Outside of the bag. DETAILED DESCRIPTION

[0056] The detailed features and advantages of this patent are described in detail below in the specific implementation method. The content is sufficient to enable any technical personnel in this field to understand the technical content of this patent and implement it accordingly. Based on the description, claims and drawings disclosed in this specification, technical personnel in this field can easily understand the relevant purposes and advantages of this patent.

[0057] It should be noted that in this specification, similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0058] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this patent pertains. The terms used herein in the specification of this patent are for the purpose of describing specific embodiments only and are not intended to limit this patent. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0059] In order to make the purpose, technical solutions and advantages of this patent clearer, the implementation methods of this patent will be further described in detail below with reference to the accompanying drawings.

[0060] The color-changing material includes an acid-base indicator, and the acid-base indicator undergoes an acid-base indicator color-changing reaction according to the pH value in the saliva.

[0061] Specifically, based on the color change principle of acid-base indicators, the pH value of saliva is usually in the weakly acidic to neutral range of 6.6-7.1. However, the pH value fluctuates due to factors such as oral microbial activity and diet. For example, phenolphthalein derivatives, in an alkaline environment, the lactone ring in their molecular structure opens to form a quinone structure, resulting in a red color.

[0062] Specifically, when alkaline substances in saliva (such as alkaline metabolites produced by oral bacteria breaking down food) come into contact with phenolphthalein derivatives, they cause a molecular structural transformation, triggering a color change. Chemical modification, such as the introduction of hydrophilic groups such as carboxyl (-COOH) or hydroxyl (-OH) onto the phenolphthalein molecule, enhances its interaction with the acidic and alkaline components in saliva, improving the sensitivity and response speed of the color change.

[0063] The advantages of acid-base indicator color change reactions include a distinct color change, with the transition from colorless to red easily observable. Furthermore, acid-base indicators are widely used in chemistry and are relatively stable, allowing them to be stored for extended periods without losing their effectiveness under certain conditions. Furthermore, appropriately modified derivatives react with saliva to produce products that are essentially harmless to the human body, meeting product safety requirements.

[0064] Specifically, the color-changing material includes an enzyme-responsive color-changing material, which undergoes a redox indicator color-changing reaction according to the enzyme in the saliva.

[0065] Specifically, the various enzymes contained in saliva, such as amylase and lysozyme, are used to react with specific materials to produce an enzymatic reaction, resulting in a color change. Taking the starch-iodine reagent system as an example, when not in contact with saliva, iodine molecules form a blue complex with starch. When the amylase in the saliva comes into contact with starch, the amylase specifically catalyzes the hydrolysis of starch, breaking down the long starch chains into small molecular sugars. As the starch is hydrolyzed, the blue complex is gradually destroyed and the color gradually fades.

[0066] Another system based on catalase, which is present in small amounts in saliva, involves applying hydrogen peroxide and a specific color developer (such as o-tolidine) to a nicotine bag. When the catalase in saliva comes into contact with hydrogen peroxide, it catalyzes its decomposition to produce oxygen, which reacts with o-tolidine, turning it from colorless to blue.

[0067] The advantages of redox indicator color changes are: Enzymatic reactions are highly specific, acting only on specific enzymes in saliva, effectively preventing interference from other external factors and improving the accuracy of color change. Furthermore, these reactions typically occur rapidly under mild oral environmental conditions, resulting in a rapid color change and providing a timely and accurate indication of product use. Furthermore, the substances involved in the reactions are relatively safe for the human body at normal usage levels.

[0068] A color-changing nicotine bag comprises an outer bag surface and an inner bag surface. The outer bag surface comprises a color-changing coating containing a color-changing material, so that the color-changing coating undergoes a color-changing reaction when the color-changing material comes into contact with saliva.

[0069] Specifically, the color-changing material of this patent can be disposed on the outer layer of the bag in a variety of ways. For example, a coating process can be used to evenly apply a solution containing the color-changing material to the surface of the bag to form a thin and uniform color-changing coating. Alternatively, a printing technique can be used to make the color-changing material into an ink with good printability, and a pattern or area containing the color-changing material can be printed on the surface of the bag through gravure printing, screen printing, or other methods. Alternatively, during the manufacturing process of the bag material, color-changing material particles can be evenly embedded into a specific outer layer area of ​​the bag material, so that they can stably exist on the outside of the bag after the material is formed, and a color change reaction will occur when the area comes into contact with saliva.

[0070] Steps to make a color-changing nicotine bag:

[0071] Coating: Prepare a color-changing solution of a certain concentration, stir for 15-30 minutes, and filter to form a uniform, pure solution. Use a coating machine to coat the nonwoven fabric. Use a coating roller to evenly apply the solution to the surface of the nonwoven, ensuring a consistent coating thickness of 0.05-0.1mm. After coating, transfer the solution to a drying oven and dry it at 80°C for 5-10 minutes, forming a thin, uniform color-changing coating on the surface of the nonwoven.

[0072] Printing: Mix the color-changing agent with an ink base (such as acrylic resin) and additives (such as a defoamer and leveling agent) in a specific proportion to create the prepared color-changing ink. Grind the mixture using a three-roll mill 3-5 times to a fineness of 15-20 μm, ensuring a uniform and smooth ink. Screen-print the ink onto the non-woven bag. After printing, place the non-woven fabric in a drying oven at 60°C for 5-10 minutes to allow the ink to dry and solidify.

[0073] This patent does not specifically limit the coating or printing method, and any method known to those skilled in the art can be used.

[0074] In the following examples, the specific raw material names and purchasing manufacturers are as follows:

[0075] Table 1 Raw material names and purchasing manufacturers

[0076]

[0077]

[0078] Example 1

[0079] Follow the steps below to make the color-changing nicotine bag D1:

[0080] Step S1: preparing a first color-changing solution containing a color-changing material;

[0081] Specifically, the color-changing material in this embodiment is a natural pH indicator - anthocyanin (black wolfberry extract). Anthocyanin powder with a purity of 25% is mixed with water to form a mixed solution with a concentration of 1.0 g / L. Citric acid is added to adjust the pH to <6, and the mixed solution is stirred for 22 minutes to obtain a uniformly mixed first color-changing solution.

[0082] Step S2: applying the first color-changing solution to the outer surface of the bag;

[0083] Specifically, a nicotine bag made of non-woven fabric is selected, and a coating machine is used to coat the outside of the bag. The coating roller evenly coats the first color-changing solution on the outside of the bag. The coating thickness is controlled to be consistent during coating. The coating thickness in this embodiment is 0.08 mm.

[0084] Step S3: drying the outside of the bag to obtain a nicotine bag;

[0085] Specifically, the nicotine bag coated with the first color-changing solution is placed in a drying oven and dried at 80° C. for 8 minutes. After the drying is completed, a color-changing coating is formed on the outside of the bag.

[0086] Specifically, a color-changing nicotine bag D1 was obtained.

[0087] Specifically, the oral material is loaded into the nicotine bag body D1 to prepare an oral nicotine bag.

[0088] For details, please refer to Figure 1 Nicotine bag D1 includes the outside of the bag body and the inside of the bag body. The outside of the bag body includes a color-changing coating containing a color-changing material. Please refer to Figure 2 , when the color-changing material comes into contact with saliva, the color-changing coating undergoes a color-changing reaction.

[0089] Specifically, the front of the nicotine bag in this embodiment is square, the end is a serrated tear strip, the length of the nicotine bag is 30 mm, the width is 15 mm, and the thickness is 2 mm.

[0090] Example 2

[0091] Follow the steps below to make the color-changing nicotine bag D2:

[0092] Step S1: preparing a second color-changing solution containing a color-changing material;

[0093] Specifically, a 0.2% (mass-to-volume ratio) starch aqueous solution is prepared, an iodine reagent with a concentration of 0.05 mol / L is diluted to an iodine solution with a concentration of 0.001 mol / L, the starch aqueous solution and the iodine solution are mixed in a volume ratio of 1:1, and the pH is adjusted to 6.8-7.2 (close to the oral pH) with 0.1 mol / L sodium dihydrogen phosphate-disodium hydrogen phosphate buffer to obtain a second color-changing solution - starch-iodine reagent.

[0094] Step S2: applying the second color-changing solution to the outer surface of the bag;

[0095] Specifically, a nicotine bag made of non-woven fabric is selected, and the prepared second color-changing solution is printed on the outside of the nicotine bag using screen printing (mesh size 120-150 mesh), and the thickness of the ink layer is controlled to be 5-10 μm.

[0096] Step S3: drying the outside of the bag to obtain a nicotine bag;

[0097] Specifically, the nicotine bag coated with the second color-changing solution was dried at 50-60° C. with hot air for 10 minutes to obtain a color-changing nicotine bag D2.

[0098] Specifically, the oral material is loaded into the nicotine bag body D2 to prepare an oral nicotine bag.

[0099] Specifically, the nicotine bag D2 includes an outer bag body and an inner bag body. The outer bag body includes a color-changing coating containing a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating undergoes a color-changing reaction.

[0100] Specifically, the front of the nicotine bag in this embodiment is square, the end is a serrated tear strip, the length of the nicotine bag is 30 mm, the width is 15 mm, and the thickness is 2 mm.

[0101] Example 3

[0102] Follow these steps to make the color-changing nicotine bag D3:

[0103] Step S1: preparing a third color-changing solution containing a color-changing material;

[0104] Specifically, the color-changing material in this embodiment is a natural pH indicator - anthocyanin (purple cabbage extract). Anthocyanin powder with a purity of 25% is mixed with water to form a mixed solution with a concentration of 1.0 g / L. Citric acid is added to adjust the pH to <6, and the mixed solution is stirred for 22 minutes to obtain a uniformly mixed third color-changing solution.

[0105] Step S2: applying the third color-changing solution to the outer surface of the bag;

[0106] Specifically, a nicotine bag made of non-woven fabric is selected, and a coating machine is used to coat the outside of the bag. The coating roller evenly coats the third color-changing solution on the outside of the bag. The coating thickness is controlled to be consistent during coating. The coating thickness in this embodiment is 0.1 mm.

[0107] Step S3: drying the outside of the bag to obtain a nicotine bag;

[0108] Specifically, the nicotine bag coated with the third color-changing solution was placed in a drying oven and dried with hot air at 50° C. for 20 minutes. After the drying was completed, a color-changing coating was formed on the outside of the bag, thereby obtaining a color-changing nicotine bag D3.

[0109] Specifically, the oral material is loaded into the nicotine bag body D3 to prepare an oral nicotine bag.

[0110] Specifically, the nicotine bag D3 includes an outer bag body and an inner bag body. The outer bag body includes a color-changing coating containing a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating undergoes a color-changing reaction.

[0111] Specifically, the front of the nicotine bag in this embodiment is square, the end is a serrated tear strip, the length of the nicotine bag is 30 mm, the width is 15 mm, and the thickness is 2 mm.

[0112] Example 4

[0113] Follow these steps to make the color-changing nicotine bag D4:

[0114] Step S1: preparing a fourth color-changing solution containing a color-changing material;

[0115] Specifically, the color-changing material in this embodiment is betacyanin. The color-changing material, ink base material, and additives are prepared into a mixed solution in a ratio of 1:5:4. The mixed solution is ground using a three-roll grinder for 4 times to obtain a fourth color-changing solution.

[0116] Specifically, the fourth color-changing solution is uniform and fine, and the fineness of the fourth color-changing solution is in the range of 15 to 20 μm.

[0117] Step S2: printing the fourth color-changing solution onto the outer surface of the bag;

[0118] Specifically, a nicotine bag made of non-woven fabric is selected, and the prepared fourth color-changing solution is printed on the outside of the nicotine bag by screen printing (mesh size 120-150 mesh), and the thickness of the ink layer is controlled to be 5-10 μm.

[0119] Step S3: drying the outside of the bag to obtain a nicotine bag;

[0120] Specifically, the nicotine bag printed with the fourth color-changing solution is placed in a drying oven and dried at 60° C. for 8 minutes. After the drying is completed, a color-changing coating is formed on the outside of the bag.

[0121] Specifically, a color-changing nicotine bag D4 was obtained.

[0122] Specifically, the oral material is loaded into the nicotine bag D4 to prepare an oral nicotine system.

[0123] Specifically, the nicotine bag D4 includes an outer bag body and an inner bag body. The outer bag body includes a color-changing coating containing a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating undergoes a color-changing reaction.

[0124] Color reaction speed test experiment

[0125] The nicotine pouches from Examples D1 to D4 were subjected to a color development reaction speed test. A 20 μL droplet of artificial saliva was pipetted onto the surfaces of different samples to simulate localized oral moisture. Three replicates were set up for each sample group. The samples were placed in a 37°C incubator to simulate oral temperature. A stopwatch was started, and the expansion of the color change area and the color change time were observed every 5 seconds. The test results are recorded in Table 2.

[0126] Table 2 Color reaction speed test results

[0127]

[0128]

[0129] Color reaction persistence test experiment

[0130] The discolored samples D1 to D4 were placed in artificial saliva and kept in a 37°C incubator for 24 hours to observe whether the color faded, became lighter, or showed abnormal changes. The test results were recorded in Table 3.

[0131] Table 3 Color reaction speed test results

[0132] Sample number Color change after 24 hours D1 Slightly faded D2 No fading, lightening or abnormal changes D3 Slightly faded D4 Slightly faded

[0133] As used herein, the term "and / or" includes any one of two or more of the listed items, as well as any and all combinations of the listed items, including any combination of any two, any more, or all of the listed items. For example, "A and / or B" includes A, B, and the combination of A and B.

[0134] In this document, unless otherwise specified, "one or more" means any one of the listed items or any combination of the listed items. Similarly, "one or more" and other expressions that mean "one or more" are also understood in the same way unless otherwise specified.

[0135] As used herein, the terms "further," "further," "particularly," "for example," "such as," "example," and "for instance" are used for descriptive purposes to indicate that the preceding and following technical solutions are related in terms of their coverage, but should not be construed as limiting the preceding technical solution or the scope of protection herein. As used herein, unless otherwise specified, "A (such as B)" means that B is a non-limiting example of A, and it should be understood that A is not limited to B.

[0136] As used herein, "optionally," "optional," and "optional" mean optional, that is, any one of the two parallel options of "with" or "without." If multiple "optional" items appear in a technical solution, unless otherwise specified and there are no contradictions or mutual constraints, each "optional" item is independent of the other. In this application, descriptions such as "optionally contain" and "optionally include" mean "containing or not containing." "Optional component X" means the presence or absence of component X, or the presence or absence of component X.

[0137] In this document, the terms "first," "second," "third," and "fourth," etc., are used for descriptive purposes only and should not be understood as indicating or implying relative importance or quantity, nor as implicitly indicating the importance or quantity of the technical features indicated. Furthermore, "first," "second," "third," and "fourth," etc., serve only as non-exhaustive enumeration and description and should not constitute a closed-ended limitation on quantity.

[0138] In this article, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0139] Herein, when referring to a numerical interval (i.e., a numerical range), unless otherwise specified, the distribution of the optional numerical values ​​within the numerical interval is considered continuous and includes the two numerical endpoints (i.e., the minimum and maximum values) of the numerical interval, and each numerical value between the two numerical endpoints. Unless otherwise specified, when a numerical interval refers only to integers within the numerical interval, including the two endpoint integers of the numerical range, and each integer between the two endpoints, is equivalent to directly listing each integer. When multiple numerical ranges are provided to describe features or characteristics, these numerical ranges can be merged. In other words, unless otherwise specified, the numerical ranges disclosed herein should be understood to include any and all subranges included therein. The "numerical value" in the numerical interval can be any quantitative value, such as a number, a percentage, a ratio, etc. "Numerical interval" allows for broad inclusion of numerical interval types such as percentage intervals, ratio intervals, and ratio intervals.

[0140] Herein, the term "room temperature" or "normal temperature" generally refers to 4°C to 35°C, for example, 20°C ± 5°C. In some embodiments herein, "room temperature" or "normal temperature" refers to 10°C to 30°C. In some embodiments herein, "room temperature" or "normal temperature" refers to 20°C to 30°C.

[0141] In this article, if a plurality of steps are involved in the method flow, unless there is a clear different description in this article, the execution of these steps is not strictly limited in order, and they can be executed in other orders other than the description. Moreover, any step may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily performed at the same time, but can be performed at different times, and their execution order is not necessarily to be carried out in sequence, but can be performed in turn or alternately or simultaneously with other steps or a part of the sub-steps or stages of other steps. The terms and expressions based on here are only used for description, and this application should not be limited to these terms and expressions. The use of these terms and expressions does not mean to exclude any equivalent features of the schematic and description (or part thereof), and it should be recognized that various modifications that may exist should also be included in the scope of the claims. Other modifications, changes and replacements may also exist. Accordingly, the claims should be deemed to cover all these equivalents.

[0142] Similarly, it should be pointed out that although the present application has been described with reference to the current specific embodiments, ordinary technicians in this technical field should realize that the above embodiments are only used to illustrate the present application, and various equivalent changes or substitutions can be made without departing from the spirit of this patent. Therefore, as long as the changes and modifications to the above embodiments are within the scope of the essential spirit of the present application, they will fall within the scope of the claims of the present application.

Claims

1. A color-changing nicotine bag, characterized in that: The nicotine bag comprises an outer bag body and an inner bag body. The outer bag body comprises a color-changing coating containing a color-changing material. When the color-changing material comes into contact with saliva, the color-changing coating changes color.

2. The nicotine bag according to claim 1, characterized in that: The color-changing material includes an acid-base indicator, and the acid-base indicator changes color according to the pH value in the saliva.

3. The nicotine bag according to claim 2, characterized in that: The acid-base indicator includes a synthetic food colorant or a natural pH indicator; The synthetic food colorant includes allura red; The natural pH indicator includes purple cabbage extract, blueberry extract, turmeric extract or red cabbage extract.

4. The nicotine bag according to claim 1, characterized in that The color-changing material includes an enzyme-responsive color-changing material, and the enzyme-responsive color-changing material undergoes an enzymatic reaction according to an enzyme in the saliva.

5. The nicotine bag according to claim 4, characterized in that: The enzymes include amylase; The enzyme-responsive color-changing material includes an iodine reagent.

6. The nicotine bag according to claim 1, characterized in that The nicotine bag is made of natural fiber, thermoplastic polymer or cellulose.

7. A color-changing nicotine bag, characterized in that: The nicotine pouch comprises the nicotine pouch body according to any one of claims 1 to 6 and an oral material contained in the nicotine pouch body.

8. The nicotine bag according to claim 7, characterized in that The oral material comprises nicotine and additives, wherein the additives comprise flavorings, sweeteners, moisturizers, pH regulators, fillers and plant fibers.

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