Biological sample storage device and management system thereof

Abstract

The invention relates to the technical field of biological sample storage, in particular to a biological sample storage device and a management system thereof, and can solve the problems that an existing biological sample storage device is limited in storage density, insufficient in sample safety guarantee and lack of intelligent management to a certain extent. Comprising a porous net plate type structure storage area, a plate frame storage area, a fan-shaped disc storage area, a blood bag box storage area and a corresponding management system, the porous net plate type structure storage area comprises different specifications of test tube storage areas and is formed by arranging high-density aluminum tubes, the inner walls of the aluminum tubes are plated with polytetrafluoroethylene coatings, and the test tube plate frame storage area is arranged at the top of each aluminum tube. The fan-shaped disc storage area is located on the lower portion of the porous net plate type structure, composed of multiple material discs and capable of storing cryopreservation tubes independently or in a mixed mode, the blood bag box storage areas are evenly distributed on the periphery of the fan-shaped disc and capable of storing blood bag boxes of different specifications, and the management system is used for monitoring and managing sample information, environment parameters, operation records and the like in the storage device.

Description

Technical Field

[0001] The present application relates to the technical field of biological sample storage, and in particular to a biological sample storage device and a management system thereof. Background Art

[0002] Early methods of preserving biological samples relied primarily on cryogenic refrigerators and liquid nitrogen tanks. While these devices could provide a low-temperature environment, their storage conditions were limited, making it difficult to fully guarantee the viability and safety of the samples. With the rapid development of precision medicine, genomics, translational medicine, big data, and artificial intelligence, the demand for biological sample resources is increasing. Biological samples are non-renewable resources that serve as the foundation for exploring the occurrence, diagnosis, treatment, and distribution of diseases. They are also a crucial component of disease prevention, intervention, control, diagnosis, treatment, and drug development.

[0003] Traditional storage systems that rely on manual racks and cryoboxes have limited storage density due to insufficient structural clearance and vertical space utilization, making them unable to meet the current demand for efficient biological sample storage. Furthermore, most existing biological sample storage devices lack intelligent management systems, making it impossible to monitor sample information and storage environment parameters in real time, making it difficult to effectively manage and trace the sample storage process.

[0004] Therefore, there is an urgent need for a biological sample storage device and its management system that can improve space utilization, ensure sample safety and stability, and have intelligent management functions. Summary of the Invention

[0005] In order to solve the problems of limited storage density, insufficient sample security and lack of intelligent management in existing biological sample storage devices, the present application provides a biological sample storage device and a management system thereof.

[0006] The embodiment of the present application is implemented as follows: In a first aspect, the present application provides a biological sample storage device, comprising a porous mesh plate structure storage area, a plate rack storage area, a fan-shaped disc storage area, and a blood bag box storage area; The porous mesh plate structure storage area includes a 2ml test tube storage area and a 0.5ml test tube storage area, which are formed by a sealed arrangement of high-density aluminum tubes of different sizes. The gaps between the 2ml test tube storage high-density aluminum tubes are used to store 0.5ml test tube storage high-density aluminum tubes. The inner walls of the high-density aluminum tubes are coated with polytetrafluoroethylene. The top of the porous mesh plate structure is provided with a storage area for a 2ml 48-well test tube plate rack, a 0.5ml 96-well test tube plate rack, and a 10×10 standard test tube plate rack; The sector-shaped disc storage area is located at the bottom of the porous mesh structure. The disc can be made of copper, aluminum or ABS. Each disc can store 0.5ml or 2.0ml cryotubes individually or in a mixed manner. The blood bag box storage area is evenly distributed around the sector-shaped disc and is used to store 25ml blood bag boxes, 50ml blood bag boxes and 250ml blood bag boxes; the management system is used to monitor and manage sample information, environmental parameters and operation records in the storage device.

[0007] In a possible implementation, the high-density aluminum tubes in the porous mesh plate structure storage area are arranged in a regular and dense array with an arrangement density of not less than 10 storage locations per square decimeter to maximize the use of storage space.

[0008] In a possible implementation, the outer wall of the high-density aluminum tube is provided with a reinforcing rib structure. The cross-section of the reinforcing rib is triangular and the height is 1 / 5 to 1 / 4 of the outer diameter of the aluminum tube to enhance the structural strength of the aluminum tube and prevent deformation.

[0009] In one possible implementation, the sector-shaped disc is in the shape of a sector with a central angle of 45° to 90°, a thickness of 3mm to 5mm, and a surface with an anti-slip texture with a texture depth of 0.1mm to 0.2mm to improve the stability and operational safety of the disc.

[0010] In one possible implementation, an elastic fixing device is provided inside each storage position of the blood bag box storage area. The elastic fixing device is made of silicone rubber material with an elastic coefficient of 0.1MPa to 0.3MPa, which can adapt to the sizes of blood bag boxes of different specifications and ensure the stability of the blood bag boxes during storage.

[0011] In one possible implementation, the plate racks in the plate rack storage area are made of aluminum alloy material, the surface is anodized, the oxide film thickness is 10μm to 15μm, and it has good wear resistance and corrosion resistance. The plate racks are provided with multiple ventilation holes, the diameter of the ventilation holes is 3mm to 5mm, and the hole spacing is 8mm to 10mm to promote gas exchange in the storage environment.

[0012] In a second aspect, the present application provides a biological sample storage device management system, including a sample information management module, an environmental parameter monitoring module, an operation recording module, and an alarm module; The sample information management module is used to store and query the basic information, storage location and status information of the sample; The environmental parameter monitoring module is used to monitor the temperature, humidity and gas composition in the storage device in real time and transmit the data to the monitoring terminal; The operation record module is used to record the time, operator and operation content of operations such as opening, closing, and sample access of the storage device; The alarm module emits an audible and visual alarm signal when the environmental parameters exceed a preset range or an abnormal situation occurs, and sends an alarm message to a preset mobile terminal.

[0013] In one possible implementation, a user rights management module is also included. This module adopts a multi-level rights management mechanism, dividing users into three levels: administrator, operator, and guest. Users of different levels have different operating rights and data access rights. Administrators can perform system settings and user management operations. The operator can perform operations such as sample storage and access and daily maintenance; Visitors are only allowed to conduct limited information queries to ensure the security of the system and the confidentiality of data.

[0014] In one possible implementation, the environmental parameter monitoring module includes a plurality of temperature sensors, humidity sensors, and gas sensors; The temperature sensor is made of high-precision thermal resistance material, with a measurement accuracy of ±0.1°C and a response time of 1s to 2s; The humidity sensor is based on the capacitive measurement principle, with a measurement accuracy of ±2%RH and a response time of 3s to 5s; The gas sensors are used to detect the concentration of gases such as oxygen and carbon dioxide, with a measurement accuracy of ±0.5% and a response time of 5s to 8s. The sensors are evenly distributed inside the storage device to ensure the accuracy and representativeness of the monitoring data.

[0015] In one possible implementation, the storage device as a whole adopts a double-layer structure design, the outer layer is an insulation layer, the insulation layer material is polyurethane foam, the thickness is 50mm to 80mm, and it has good thermal insulation performance, the inner layer is a storage layer, and a plurality of partitions are provided inside the storage layer. The partitions are removable, and the layout of the storage area can be flexibly adjusted according to different sample storage requirements. A mobile base is provided at the bottom of the storage device, and four universal wheels are installed on the base. The universal wheels have a self-locking function to facilitate the movement and fixation of the storage device.

[0016] The technical solution provided by this application can achieve at least the following beneficial effects: The present invention realizes the mixed storage of test tubes of different specifications through the innovative design of the porous mesh plate structure, and adopts physical isolation to solve the technical problem of mixed storage of test tubes of different specifications, improves storage efficiency and space utilization, and is compatible with the storage of whole plates of biological samples and blood boxes (bags). The various storage areas cooperate with each other to form an integrated storage system, which can realize independent operation control, flexible and convenient operation, and meet the storage needs of different biological samples.

[0017] The present invention adopts high-density aluminum tubes as test tube storage structures, and the inner wall is coated with polytetrafluoroethylene, which increases lubricity, reduces the risk of test tube jamming, and improves the safety and reliability of sample storage. The fan-shaped disc storage area can select discs of different materials according to actual needs, adapting to the storage of cryopreservation tubes of different specifications and types, further improving the versatility and flexibility of the storage device. The evenly distributed layout of the blood bag box storage area rationally utilizes the space of the storage device, improves the storage density, and facilitates the storage and retrieval of blood bag boxes. The plate rack storage area is made of aluminum alloy material, and the surface is anodized, which has good wear resistance and corrosion resistance. The vent design on the plate rack promotes gas exchange in the storage environment, which is beneficial to the preservation of samples.

[0018] The present invention realizes comprehensive monitoring and management of sample information, environmental parameters and operation records in the storage device through the management system, improves the management level and security of sample storage through intelligent means, and facilitates management personnel to query, count and trace samples. The alarm function of the management system can issue an alarm and notify relevant personnel in time when the environmental parameters are abnormal, effectively ensuring the safety of samples and reducing the risk of sample loss due to environmental changes. The user authority management module ensures the security of the system and the confidentiality of data, prevents unauthorized access and operation, and ensures the security of sample information.

[0019] The storage device of the present invention adopts a double-layer structure design as a whole. The outer insulation layer is made of polyurethane foam material with good thermal insulation performance. The detachable partition design of the inner storage layer can flexibly adjust the layout according to different sample storage requirements. The mobile base at the bottom is equipped with self-locking universal wheels, which facilitates the movement and fixation of the storage device, thereby improving the practicality and convenience of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0021] Figure 1is a schematic diagram of the three-dimensional structure of a biological sample storage device shown in an exemplary embodiment of the present application; Figure 2 is a schematic diagram of an axial structure of a biological sample storage device according to an exemplary embodiment of the present application; Figure 3 This is a schematic diagram of the three-dimensional structure of a porous mesh plate structure storage area shown in an exemplary embodiment of the present application; Figure 4 This is an axial structural diagram of a porous mesh plate structure storage area shown in an exemplary embodiment of the present application; Figure 5 1 is a schematic structural diagram of a rack structure storage area according to an exemplary embodiment of the present application; Figure 6 1 is a schematic structural diagram of a blood bag box storage area according to an exemplary embodiment of the present application; Figure 7 1 is a schematic structural diagram of a disk storage area according to an exemplary embodiment of the present application; Figure 8 FIG1 is a structural diagram of a biological sample storage device management system shown in an exemplary embodiment of the present application.

[0022] Reference numerals: 1. 2ml cryogenic tubes; 2. 0.5ml cryogenic tubes; 3. 48-well 2ml cryogenic tube plate rack; 4. 96-well 0.5ml cryogenic tube plate rack; 5. 10×10 standard plate rack; 6. Fan-shaped disc; 7. Blood bag box; 81. Sample information management module; 82. Environmental parameter monitoring module; 83. Operation record module; 84. Alarm module; 85. User authority management module. DETAILED DESCRIPTION

[0023] In order to make the purpose, implementation methods and advantages of the present application clearer, the exemplary implementation methods of the present application will be clearly and completely described below in conjunction with the drawings in the exemplary embodiments of the present application. Obviously, the described exemplary embodiments are only part of the embodiments of the present application, not all of the embodiments. It should be understood that the specific embodiments described here are only used to explain the present application and are not used to limit the present application.

[0024] It should be noted that the brief descriptions of terms in this application are only for the purpose of facilitating the understanding of the embodiments described below, and are not intended to limit the embodiments of this application. Unless otherwise specified, these terms should be understood according to their ordinary and usual meanings.

[0025] In the specification and claims of this application and the accompanying drawings, the terms "first," "second," "third," etc. are used to distinguish similar or similar objects or entities, and are not necessarily intended to limit a particular order or sequence, unless otherwise noted. It should be understood that the terms used in this manner are interchangeable under appropriate circumstances.

[0026] The terms "comprise," "include," and "have," and any variations thereof, are intended to cover but not exclude inclusion; for example, a product or device comprising a list of components is not necessarily limited to all the components expressly listed but may include other components not expressly listed or inherent to such product or device.

[0027] Before explaining the biological sample storage device provided by the embodiment of the present application, the application scenario and implementation environment of the embodiment of the present application are first introduced.

[0028] Early methods of preserving biological samples relied primarily on cryogenic refrigerators and liquid nitrogen tanks. While these devices could provide a low-temperature environment, their storage conditions were limited, making it difficult to fully guarantee the viability and safety of the samples. With the rapid development of precision medicine, genomics, translational medicine, big data, and artificial intelligence, the demand for biological sample resources is increasing. Biological samples are non-renewable resources that serve as the foundation for exploring the occurrence, diagnosis, treatment, and distribution of diseases. They are also a crucial component of disease prevention, intervention, control, diagnosis, treatment, and drug development.

[0029] Traditional storage systems that rely on manual racks and cryoboxes have limited storage density due to insufficient structural clearance and vertical space utilization, making them unable to meet the current demand for efficient biological sample storage. Furthermore, most existing biological sample storage devices lack intelligent management systems, making it impossible to monitor sample information and storage environment parameters in real time, making it difficult to effectively manage and trace the sample storage process.

[0030] Therefore, there is an urgent need for a biological sample storage device and its management system that can improve space utilization, ensure sample safety and stability, and have intelligent management functions.

[0031] Based on this, this application provides a biological sample storage device and its management system. Through innovative design and integration of multiple structures, it effectively improves space utilization, achieves ultra-high-density storage, ensures sample safety and stability, and at the same time uses the management system to achieve intelligent management. It is suitable for the long-term preservation of various biological samples and provides efficient and reliable sample storage solutions for scientific research and medical fields.

[0032] Next, the technical solution of the present application and how the technical solution of the present application solves the above-mentioned technical problems will be described in detail through embodiments and in conjunction with the accompanying drawings. The various embodiments can be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments. Obviously, the described embodiments are only part of the embodiments of the present application, not all of them.

[0033] Figure 1 FIG1 is a schematic diagram of the three-dimensional structure of a biological sample storage device shown in an exemplary embodiment of the present application.

[0034] In an exemplary embodiment, Figure 1 As shown, a biological sample storage device is provided. In this embodiment, the storage device may include a porous mesh plate structure storage area, a plate rack storage area, a fan-shaped disc storage area and a blood bag box storage area; The porous mesh plate structure storage area includes a 2ml test tube storage area and a 0.5ml test tube storage area, which are formed by a sealed arrangement of high-density aluminum tubes of different sizes. The gaps between the 2ml test tube storage high-density aluminum tubes are used to store 0.5ml test tube storage high-density aluminum tubes. The inner walls of the high-density aluminum tubes are coated with polytetrafluoroethylene to increase lubrication and reduce the risk of test tube jamming.

[0035] The sector-shaped disc storage area is located at the bottom of the porous mesh structure. The disc can be made of different materials such as copper, aluminum or ABS. Each disc can store 0.5ml cryotube 2 or 2.0ml cryotube 1 separately, or can store 0.5ml or 2.0ml cryotubes in a mixed manner.

[0036] The blood bag box storage area is evenly distributed around the fan-shaped disc and is used to store 25ml blood bag boxes, 50ml blood bag boxes and 250ml blood bag boxes.

[0037] The plate racks in the plate rack storage area are made of aluminum alloy material, the surface is anodized, the oxide film thickness is 10μm to 15μm, and it has good wear resistance and corrosion resistance. The plate racks are provided with multiple ventilation holes with a diameter of 3mm to 5mm and a hole spacing of 8mm to 10mm to promote gas exchange in the storage environment.

[0038] Figure 2 FIG1 is a schematic diagram of an axial structure of a biological sample storage device according to an exemplary embodiment of the present application. Figure 3 This is a schematic diagram of the three-dimensional structure of a porous mesh plate structure storage area shown in an exemplary embodiment of the present application. Figure 4 This is an axial structural diagram of a porous mesh plate structure storage area shown in an exemplary embodiment of the present application. Figure 5is a structural diagram of a rack structure storage area shown in an exemplary embodiment of the present application. Figure 6 FIG. 1 is a structural diagram of a blood bag box storage area shown in an exemplary embodiment of the present application. Figure 7 FIG. 1 is a schematic structural diagram of a disk storage area according to an exemplary embodiment of the present application.

[0039] In some embodiments, as Figure 2 As shown, the specific structure of the storage device includes a porous mesh plate structure storage area, a plate rack storage area, a fan-shaped disc storage area and a blood bag box storage area.

[0040] like Figure 3 and Figure 4 As shown, the porous mesh storage area is a core component of the device. It comprises a 2ml test tube storage area and a 0.5ml test tube storage area, each composed of a sealed arrangement of high-density aluminum tubes of corresponding specifications. These high-density aluminum tubes are arranged in a regular and dense array, with a density of no less than 10 storage locations per square decimeter, to maximize storage space utilization.

[0041] The 0.5ml test tube storage high-density aluminum tubes are cleverly stored in the gaps between the 2ml test tube storage high-density aluminum tubes, achieving a compact layout of the storage structure for test tubes of different specifications and improving the storage density.

[0042] To reduce the risk of test tubes getting stuck during insertion and removal, the inner wall of the high-density aluminum tube is coated with a polytetrafluoroethylene coating. This coating has excellent lubricating properties, allowing the test tubes to move in and out of the aluminum tube smoothly, effectively ensuring the smooth progress of sample storage operations.

[0043] The top of the porous mesh plate structure is also provided with storage areas for a 48-well 2ml cryotube rack 3, a 96-well 0.5ml cryotube rack 4, and a 10×10 standard rack 5, which facilitates the storage and use of test tube racks of different specifications and further improves the flexibility and versatility of the storage device.

[0044] The porous mesh panel structure adopts a double-layer reinforcement design, with a metal support frame at the bottom. The frame is made of aluminum alloy profiles with a rectangular cross-section and a wall thickness of 3mm to 5mm. The support frame is connected to the main structure of the storage device by bolts. The strength grade of the connecting bolts is 8.8 to ensure the stability and load-bearing capacity of the porous mesh panel structure.

[0045] like Figure 7As shown, the sector-shaped disc storage area is located at the bottom of the porous mesh plate structure. The disc can be made of different materials such as copper, aluminum or ABS. The design of each sector-shaped disc 6 fully takes into account the actual needs of biological sample storage. It can store 0.5ml or 2.0ml cryotubes separately or in a mixed manner, meeting diverse storage requirements. The sector-shaped disc is in the shape of a sector with a central angle of 45° to 90°, a thickness of 3mm to 5mm, and a non-slip texture on the surface with a texture depth of 0.1mm to 0.2mm to improve the stability and operational safety of the disc. The disc is installed in the storage device through a rotating bracket. The rotating bracket is made of stainless steel. The diameter of the rotating shaft of the bracket is 8mm to 10mm. The surface of the shaft is chrome-plated and the hardness reaches HRC55 to 60, ensuring that the disc can rotate flexibly and be used stably for a long time.

[0046] like Figure 6 As shown, the blood bag storage area is evenly distributed around the sector-shaped disc, forming a wraparound layout. This layout allows the blood bag storage area to fully utilize the space surrounding the storage device, improving space utilization. Each storage location in the blood bag storage area is equipped with an elastic fixture. Made of silicone rubber, the elastic modulus ranges from 0.1MPa to 0.3MPa, adapting to the dimensions of blood bags of varying specifications and ensuring the stability of the blood bag boxes 7 during storage. A transparent cover is installed at the opening of the storage location. The cover is made of high-strength polycarbonate and is 3mm to 5mm thick. The cover is connected to the storage location via a hinge made of stainless steel, which is corrosion-resistant and reliable. This hinge protects the blood bag boxes from external contamination while facilitating easy observation and access.

[0047] like Figure 5 As shown, the plate rack in the plate rack storage area is made of aluminum alloy material, the surface is anodized, the oxide film thickness is 10μm to 15μm, with good wear resistance and corrosion resistance, and a plurality of ventilation holes are provided on the plate rack. The diameter of the ventilation holes is 3mm to 5mm, and the hole spacing is 8mm to 10mm to promote gas exchange in the storage environment. The plate rack is installed in the storage device through an adjustable support column. The diameter of the support column is 15mm to 20mm, the adjustable length range is 100mm to 200mm, and the adjustment accuracy is 1mm. The material of the support column is stainless steel, and the surface is polished with a roughness Ra≤0.8μm to ensure the stability and adjustability of the plate rack and meet the installation requirements of plate racks of different heights.

[0048] It should be understood that, although the various steps in the flowcharts involved in the above-described embodiments are displayed in sequence according to the instructions, these steps are not necessarily executed in the order indicated. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and these steps can be executed in other orders. Moreover, at least a portion of the steps in the flowcharts involved in the above-described embodiments may include multiple steps or multiple stages, and these steps or stages are not necessarily executed at the same time, but can be executed at different times. The execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a portion of steps or stages in other steps.

[0049] Corresponding to the aforementioned embodiments of the biological sample storage device, the present application also provides an embodiment of a biological sample storage device management system.

[0050] Figure 8 FIG1 is a structural diagram of a biological sample storage device management system shown in an exemplary embodiment of the present application.

[0051] In an exemplary embodiment, Figure 8 As shown, the biological sample storage device management system includes a sample information management module 81, an environmental parameter monitoring module 82, an operation recording module 83 and an alarm module 84; The sample information management module is used to store and query the basic information, storage location and status information of the sample.

[0052] In some embodiments, the basic information, storage location and status information of the sample include sample number, name, type, collection time, collection location, project, storage location coordinates, entry time, exit time, sample status (normal, abnormal, expired, etc.). This module uses a relational database for data storage. The database supports concurrent access by multiple users and has data backup and recovery functions to ensure data security and integrity.

[0053] The environmental parameter monitoring module is used to monitor the temperature, humidity and gas composition in the storage device in real time and transmit the data to the monitoring terminal.

[0054] The operation record module is used to record the time, operator and operation content of operations such as opening, closing, and sample access of the storage device.

[0055] The alarm module emits an audible and visual alarm signal when the environmental parameters exceed a preset range or an abnormal situation occurs, and sends an alarm message to a preset mobile terminal.

[0056] Furthermore, this application also includes a user rights management module 85, which uses a multi-level rights management mechanism to divide users into three levels: administrator, operator, and guest. Different levels of users have different operating permissions and data access rights. Administrators can perform operations such as system settings, user management, and data backup and recovery; operators can perform operations such as sample access, daily maintenance, and environmental parameter settings; and guests can only perform limited information queries. Users are required to authenticate their identities when logging into the system. Authentication methods include username and password, fingerprint recognition, facial recognition, and other methods to ensure system security and data confidentiality.

[0057] In some embodiments, the management system specifically includes a sample information management module, an environmental parameter monitoring module, an operation record module, an alarm module and a user authority management module.

[0058] The sample information management module is used to store and query the basic information, storage location and status information of the sample, including sample number, name, type, collection time, collection location, project, storage location coordinates, entry time, exit time, sample status, etc. This module uses a relational database for data storage. The database supports concurrent access by multiple users and has data backup and recovery functions to ensure data security and integrity.

[0059] The environmental parameter monitoring module monitors the temperature, humidity, and gas composition within the storage device in real time and transmits this data to the monitoring terminal. The temperature sensor, made of high-precision thermal resistor material, offers a measurement accuracy of ±0.1°C and a response time of 1 to 2 seconds. The humidity sensor, based on a capacitive measurement principle, offers a measurement accuracy of ±2%RH and a response time of 3 to 5 seconds. The gas sensor detects the concentration of gases such as oxygen and carbon dioxide, with a measurement accuracy of ±0.5% and a response time of 5 to 8 seconds. These sensors are evenly distributed within the storage device to ensure the accuracy and representativeness of the monitored data. The monitoring terminal displays real-time environmental parameter curves and data tables, and also supports historical data query and analysis.

[0060] The operation record module is used to record the time, operator and operation content of operations such as opening, closing, and sample access of the storage device. Each time an operation is triggered, the system automatically records the relevant information and stores it in the operation log database. The operation log supports filtering and querying by time, operator, operation type and other conditions, making it convenient for managers to trace and audit the operation process of the storage device.

[0061] The alarm module generates audible and visual alarm signals when environmental parameters exceed preset ranges or abnormal conditions occur, and sends an alert message to a pre-set mobile terminal. Alarm thresholds can be flexibly configured to suit the storage requirements of different samples. For example, the temperature alarm threshold can be set to -20°C ±2°C, and the humidity alarm threshold can be set from 30%RH to 70%RH. Alarm information includes details such as the alarm time, alarm type, and alarm location, ensuring that managers receive alerts promptly and take appropriate measures.

[0062] The user authority management module adopts a multi-level authority management mechanism, dividing users into three levels: administrators, operators and visitors. Users at different levels have different operating permissions and data access rights. Administrators can perform system settings, user management, data backup and recovery, etc.; operators can perform sample access, daily maintenance, environmental parameter settings, etc.; visitors can only perform limited information queries. Users are required to authenticate their identities when logging into the system. Verification methods include username and password, fingerprint recognition, facial recognition, etc. to ensure the security of the system and the confidentiality of data.

[0063] In actual applications, staff enter sample information through the management system, including sample number, name, type, collection time and other detailed information, and allocate appropriate storage locations for samples according to the layout of the storage device.

[0064] When samples need to be stored, staff place the samples in the designated storage location according to the system prompts. The management system automatically updates the storage status and location information of the samples. At the same time, the environmental parameter monitoring module monitors the temperature, humidity and other environmental parameters in the storage device in real time and transmits the data to the monitoring terminal.

[0065] Managers can view environmental parameter curves and data tables in real time through the monitoring terminal to ensure that the storage environment meets the sample preservation requirements. If the environmental parameters are abnormal, the alarm module will immediately emit an audible and visual alarm signal and send an alarm message to the preset mobile terminal to remind managers to take timely measures.

[0066] All operation records, including sample access, environmental parameter settings, alarm processing, etc., will be recorded in detail by the operation record module for subsequent traceability and auditing. Through the user authority management module, the system ensures that only authorized personnel can perform corresponding operations, ensuring the security of sample information and the stable operation of the system.

[0067] It can be seen that the biological sample storage device and management system thereof provided in some embodiments of the present application have demonstrated many advantages in practical applications.

[0068] On the one hand, through innovative structural design, efficient storage of biological samples of different specifications and types is achieved, and storage density and space utilization are improved.

[0069] On the other hand, with the help of an intelligent management system, refined management and monitoring of the entire sample storage process is achieved, improving the safety and reliability of sample storage.

[0070] This device and its management system provide a comprehensive and intelligent solution for the long-term preservation and effective utilization of biological samples, and have broad application prospects and important practical significance.

[0071] It should be understood that the technical solutions in the embodiments of the present application can be implemented by means of software plus a necessary general-purpose hardware platform. Therefore, the technical solutions in the embodiments of the present application, in essence, or the portion that contributes to the prior art, can be embodied in the form of a software product, which can be stored in a computer-readable storage medium.

[0072] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0073] The embodiments described above merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art could make various modifications and improvements without departing from the spirit of the present application, all of which fall within the scope of protection of the present application. Therefore, the scope of protection of the present patent application shall be determined by the appended claims.

Claims

1. A biological sample storage device, characterized in that: It includes porous mesh plate structure storage area, plate rack storage area, fan-shaped disc storage area and blood bag box storage area; The porous mesh plate structure storage area includes a 2ml test tube storage area and a 0.5ml test tube storage area, which are formed by a sealed arrangement of high-density aluminum tubes of different sizes. The gaps between the 2ml test tube storage high-density aluminum tubes are used to store 0.5ml test tube storage high-density aluminum tubes. The inner walls of the high-density aluminum tubes are coated with polytetrafluoroethylene. The top of the porous mesh plate structure is provided with a storage area for a 2ml 48-well test tube plate rack, a 0.5ml 96-well test tube plate rack, and a 10×10 standard test tube plate rack; The sector-shaped disc storage area is located at the bottom of the porous mesh structure. The disc can be made of copper, aluminum or ABS. Each disc can store 0.5ml or 2.0ml cryotubes individually or in a mixed manner. The blood bag box storage area is evenly distributed around the sector-shaped disc and is used to store 25ml blood bag boxes, 50ml blood bag boxes and 250ml blood bag boxes; the management system is used to monitor and manage sample information, environmental parameters and operation records in the storage device.

2. The biological sample storage device according to claim 1, wherein: The high-density aluminum tubes in the porous mesh plate structure storage area are arranged in a regular and dense array with an arrangement density of not less than 10 storage locations per square decimeter to maximize the use of storage space.

3. The biological sample storage device according to claim 1, wherein: The outer wall of the high-density aluminum tube is provided with a reinforcing rib structure. The cross-section of the reinforcing rib is triangular and the height is 1 / 5 to 1 / 4 of the outer diameter of the aluminum tube to enhance the structural strength of the aluminum tube and prevent deformation.

4. The biological sample storage device according to claim 1, wherein: The sector-shaped disc is in the shape of a sector with a central angle of 45° to 90°, a thickness of 3mm to 5mm, and a surface with an anti-slip texture with a texture depth of 0.1mm to 0.2mm to improve the stability and operational safety of the disc.

5. The biological sample storage device according to claim 1, wherein: Each storage position in the blood bag box storage area is provided with an elastic fixing device, which is made of silicone rubber material with an elastic coefficient of 0.1MPa to 0.3MPa, and can adapt to the sizes of blood bag boxes of different specifications to ensure the stability of the blood bag boxes during storage.

6. The biological sample storage device according to claim 1, wherein: The plate racks in the plate rack storage area are made of aluminum alloy material, the surface is anodized, the oxide film thickness is 10μm to 15μm, and it has good wear resistance and corrosion resistance. The plate racks are provided with multiple ventilation holes with a diameter of 3mm to 5mm and a hole spacing of 8mm to 10mm to promote gas exchange in the storage environment.

7. A biological sample storage device management system, characterized in that: It includes sample information management module, environmental parameter monitoring module, operation record module and alarm module; The sample information management module is used to store and query the basic information, storage location and status information of the sample; The environmental parameter monitoring module is used to monitor the temperature, humidity and gas composition in the storage device in real time and transmit the data to the monitoring terminal; The operation record module is used to record the time, operator and operation content of operations such as opening, closing, and sample access of the storage device; The alarm module emits an audible and visual alarm signal when the environmental parameters exceed a preset range or an abnormal situation occurs, and sends an alarm message to a preset mobile terminal.

8. The biological sample storage device management system according to claim 7, wherein: It also includes a user rights management module, which adopts a multi-level rights management mechanism and divides users into three levels: administrator, operator and visitor. Different levels of users have different operating permissions and data access permissions. Administrators can perform system settings and user management operations. The operator can perform operations such as sample storage and access and daily maintenance; Visitors are only allowed to conduct limited information queries to ensure the security of the system and the confidentiality of data.

9. The biological sample storage device management system according to claim 7, wherein: The environmental parameter monitoring module includes multiple temperature sensors, humidity sensors and gas sensors; The temperature sensor is made of high-precision thermal resistance material, with a measurement accuracy of ±0.1°C and a response time of 1s to 2s; The humidity sensor is based on the capacitive measurement principle, with a measurement accuracy of ±2%RH and a response time of 3s to 5s; The gas sensors are used to detect the concentration of gases such as oxygen and carbon dioxide, with a measurement accuracy of ±0.5% and a response time of 5s to 8s. The sensors are evenly distributed inside the storage device to ensure the accuracy and representativeness of the monitoring data.

10. The biological sample storage device management system according to claim 7, wherein: The storage device adopts a double-layer structure design as a whole. The outer layer is an insulation layer. The insulation layer material is polyurethane foam with a thickness of 50mm to 80mm, which has good thermal insulation performance. The inner layer is a storage layer. There are multiple partitions inside the storage layer. The partitions are removable and the layout of the storage area can be flexibly adjusted according to different sample storage requirements. A mobile base is provided at the bottom of the storage device. The base is equipped with four universal wheels. The universal wheels have a self-locking function to facilitate the movement and fixation of the storage device.

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