Biological fluid sample detection device

Abstract

The invention relates to the technical field of sample detection, in particular to a biological fluid sample detection device, which comprises a box body, and a conveying mechanism, a consumable storage mechanism, a sampling mechanism, a waste collection mechanism and a detection mechanism which are arranged in the box body, the conveying mechanism is used for feeding and discharging the sample cups in the box body; a slide and a gun head are stored in the consumable storage mechanism; the sampling mechanism comprises a slide grabbing assembly and a pipetting assembly; the slide grabbing assembly has multiple degrees of freedom so as to transfer slides; the pipetting assembly has multiple degrees of freedom to realize sample transfer; and the detection mechanism is used for detecting a sample carried on the slide. According to the invention, the sample cup enters and exits from the box body through the conveying mechanism, the volume of the sample sucked each time and / or the volume of the sample used for detection are ensured to be consistent through the pipetting assembly, and pollution between the samples is avoided by using the disposable slide and the gun head, so that the detection efficiency is improved, and the accuracy of the detection result is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of sample detection, and in particular to a detection device for biological fluid samples. Background Art

[0002] When testing biological fluid samples (such as semen), observation and / or image / video capture are often performed using a microscope or other testing device. Existing microscopes are typically semi-automatic, often requiring manual sampling, reagent addition, and placement under the microscope for testing. This process is time-consuming and laborious when testing a large number of samples. Furthermore, during the testing process, it is not possible to ensure that the amount of sample taken and reagent added each time remains within a stable and controllable range, which can easily affect the accuracy of the test results. Summary of the Invention

[0003] In view of this, the present invention provides a detection device for biological fluid samples, aiming to improve detection efficiency and ensure the accuracy of detection results.

[0004] In order to solve the above technical problems, the technical solution adopted by the present invention is: A biological fluid sample detection device includes a housing and a conveying mechanism, a consumables storage mechanism, a sampling mechanism, a waste collection mechanism, and a detection mechanism disposed within the housing. The housing is provided with an inlet and an outlet corresponding to the input and output ends of the conveying mechanism, respectively. The conveying mechanism is used to convey a sample cup containing a sample into the housing or to convey a sample cup that has completed testing out of the housing. The consumables storage mechanism contains a glass slide and a gun tip. The sampling mechanism includes a glass slide grabbing assembly and a pipetting assembly. The glass slide grabbing assembly has multiple degrees of freedom for removing a glass slide from the consumables storage mechanism and transferring the removed glass slide to the detection mechanism, or transferring a glass slide that has completed testing from the detection mechanism to the waste collection mechanism. The pipetting assembly has multiple degrees of freedom for installing a gun tip within the consumables storage mechanism, aspirating a sample from a sample cup into the gun tip and discharging the sample onto a removed glass slide, or dropping a used gun tip into the waste collection mechanism. The detection mechanism is used to detect the sample carried on the glass slide.

[0005] In some optional embodiments, the system further includes a sample cup transport mechanism and a sample cup placement mechanism disposed within the housing; the sample cup transport mechanism includes a clamping mechanism with multiple degrees of freedom to transfer the sample cup from the conveying mechanism to the sample cup placement mechanism, or to transfer the sample cup that has completed testing from the sample cup placement mechanism to the conveying mechanism.

[0006] In some optional embodiments, the sample cup placement mechanism includes a weighing assembly and a placement seat; the clamping mechanism can also transfer the sample cup from the conveying mechanism to the weighing assembly for weighing, transfer the weighed sample cup from the weighing assembly to the placement seat, or transfer the tested sample cup from the placement seat to the conveying mechanism; the consumables storage mechanism also stores reagent bottles; the pipetting assembly can also absorb the reagent from the reagent bottle into the gun tip and discharge the reagent into the sample cup.

[0007] In some optional embodiments, the sample cup placement mechanism further includes a vibration mechanism; the vibration mechanism cooperates with the placement seat to apply an excitation force to the placement seat.

[0008] In some optional embodiments, it further includes a glass slide placement table provided in the box; the glass slide grabbing component is also provided with a sample property judgment component; the glass slide grabbing component can also take out the glass slide from the consumables storage mechanism and transfer it to the glass slide placement table so that the sample can be sucked from the sample cup by the pipetting component and the sample can be discharged onto the taken out glass slide, and the sample property judgment component can be used to judge the property of the sample to determine whether reagents need to be added.

[0009] In some optional embodiments, the glass slides stored in the consumables storage mechanism include glass slides with test papers and ordinary glass slides; the glass slide grabbing component can take out the glass slide with test papers from the consumables storage mechanism and transfer it to the glass slide placement table so that the sample can be aspirated from the sample cup by the pipetting component and the sample can be discharged onto the glass slide with test papers to react with the sample carried thereon, and the sample property judgment component can judge the property of the sample to determine whether reagents need to be added; or, the glass slide grabbing component can take out the ordinary glass slide from the consumables storage mechanism and transfer it to the detection mechanism so that the sample or a mixture of sample and reagent can be aspirated from the sample cup by the pipetting component and the sample or the mixture can be discharged onto the ordinary glass slide on the detection mechanism.

[0010] In some optional embodiments, the sampling mechanism further includes a first driving mechanism for driving the pipetting component to take and discharge liquid, and a second driving mechanism for driving the pipetting component to detach the gun tip.

[0011] In some optional embodiments, the consumable material storage mechanism and the waste collection mechanism are both slidably disposed on the box body to achieve entry and exit relative to the box body.

[0012] In some optional embodiments, a temperature detection component and a temperature adjustment component are further provided in the box.

[0013] In some optional embodiments, the box is further provided with a code scanning component to read the graphic code identification information on the sample cup.

[0014] In summary, compared with the prior art, the present invention has the following advantages and beneficial effects: the present invention uses a conveying mechanism to complete the entry and exit of the sample cup in the box, uses a pipetting component to ensure that the volume of the sample aspirated each time and / or the sample used for testing is consistent, and uses disposable glass slides and gun tips to avoid contamination between samples, thereby improving detection efficiency and ensuring the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural schematic diagram of the present invention, Figure 1 The housing is omitted.

[0016] Figure 2 It mainly shows the assembly structure of the sample cup transport mechanism and the sampling mechanism on the box body in the present invention.

[0017] Figure 3 for Figure 2 The structure shown is a schematic diagram of the structure after the box is omitted.

[0018] Figure 4 Shown Figure 3 Related structures of the sample cup transport mechanism.

[0019] Figure 5 Shown Figure 3 Related structures of the sampling agency.

[0020] Figure 6 It mainly shows the assembly structure among the conveying mechanism, sample cup placement mechanism, consumables storage mechanism, slide placement table, waste collection mechanism and detection mechanism in the present invention.

[0021] Figure 7 It is a structural schematic diagram of the sample cup placement mechanism in the present invention.

[0022] Figure 8 for Figure 7 The structure shown omits the schematic diagram of the structure after the platform is placed.

[0023] Figure 9 It is a structural schematic diagram of the consumables storage mechanism in the present invention.

[0024] : The meanings of the reference numerals in the figure are: box 1, conveying mechanism 2, sample cup transport mechanism 3, second lateral moving component 31, third longitudinal moving component 32, third vertical moving component 33, clamping mechanism 34, sample cup placement mechanism 4, bottom plate 41, weighing component 42, weighing sensor 43, tray 44, detection sensor 45, elastic reset member 46, vibration mechanism 47, placement platform 48, placement seat 49, consumables storage mechanism 5, first base 51, slide rail 52, slide box 53, slide 54, gun tip box 55, gun tip 56, reagent bottle 57, sampling mechanism 6, first lateral moving component 61, first longitudinal moving component 62, first vertical moving component 63, first rotating component 64, slide grabbing component 65, sample property judgment component 66, second longitudinal moving component 67, second vertical moving component 68, second rotating component 69, pipetting component 610, slide placement table 7, waste collection mechanism 8, detection mechanism 9, sample cup 10. DETAILED DESCRIPTION

[0025] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention is further described in detail below in conjunction with specific implementation methods.

[0026] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present invention.

[0027] In the description of the present invention, "several" means one or more, "many" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of terms such as "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0028] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, and connecting should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0029] like Figure 1As shown, the present invention introduces a biological fluid sample detection device, including a housing 1, a conveying mechanism 2, a consumable material storage mechanism 5, a sampling mechanism 6, a waste collection mechanism 8, and a detection mechanism 9. For ease of description, the spatial rectangular coordinate system shown in the accompanying drawings is introduced to illustrate the relevant structure of the present invention, wherein the positive direction of the X axis is the back, the positive direction of the Y axis is the left, and the positive direction of the Z axis is the top.

[0030] The housing 1 serves as the mounting base for the other mechanisms. It includes a shell that creates a closed space within the housing, preventing air flow and maintaining a stable internal temperature. The conveying mechanism 2, consumables storage mechanism 5, sampling mechanism 6, waste collection mechanism 8, and detection mechanism 9 are all mounted within the housing 1.

[0031] The housing 1 is provided with an inlet and an outlet, respectively, corresponding to the input and output ends of the conveying mechanism 2. For example, the inlet is provided on the left side of the housing 1, and the outlet is provided on the right side. The shape and opening size of the inlet and outlet are preferably consistent with those of the sample cup 10 to minimize the impact of the sample cup 10 on the internal temperature when entering and exiting the housing 1.

[0032] The conveying mechanism 2 is used to convey the sample cup 10 containing the sample from the outside to the box 1, or to convey the sample cup 10 after testing from the box 1 to the outside. The conveying mechanism 2 can be a belt conveyor, a roller conveyor, a chain conveyor, a mesh belt conveyor, a chain conveyor, or a combination of one or more of the following.

[0033] like Figure 9 As shown, a glass slide 54 and a gun tip 56 are stored in the consumables storage mechanism 5. The glass slide 54 is used to carry the sample in the sample cup 10, and the gun tip 56 is used to be assembled on the pipetting component 610 in the sampling mechanism 6.

[0034] like Figure 2 、 Figure 3 and Figure 5 As shown, the sampling mechanism 6 includes a glass slide grabbing component 65 and a pipetting component 610.

[0035] Among them, the glass slide grabbing assembly 65 has multiple degrees of freedom, including at least the translational freedom for reciprocating linear motion in the X, Y, and Z axes and at least the rotational freedom for rotation around the Z axis, so as to realize operations including taking out the glass slide 54 from the consumable storage mechanism 5, carrying the sample on the taken out glass slide 54 and transferring it to the detection mechanism 9, or transferring the glass slide 54 that has completed the inspection from the detection mechanism 9 to the waste collection mechanism 8.

[0036] The pipetting assembly 610 also has multiple degrees of freedom, including at least a translational degree of freedom for reciprocating linear motion in the X, Y, and Z axes and a rotational degree of freedom for rotating at least about the X axis, so as to realize operations including installing the gun tip 56 in the consumable storage mechanism 5, sucking the sample from the sample cup 10 into the gun tip 56 and discharging the sample onto the removed glass slide 54, or dropping the used gun tip 56 into the waste collection mechanism 8.

[0037] The detection mechanism 9 is used to detect the sample carried on the glass slide 54. The detection mechanism 9 can be a microscope, especially an electron microscope to meet the detection requirements.

[0038] The workflow of the present invention is roughly as follows: In process 1, the sample cup 10 containing the sample is transported to a designated position in the housing 1 by the transport mechanism 2; for example, when the sample cup 10 reaches the designated position, the transport mechanism 2 stops running so that the sample cup 10 stops at the designated position on the transport mechanism 2; In process 2, the glass slide grabbing assembly 65 in the sampling mechanism 6 takes the glass slide 54 out of the consumables storage mechanism 5 and places it in a designated position; In process three, the pipetting assembly 610 in the sampling mechanism 6 first moves to the consumables storage mechanism 5 to install the pipette tip 56, then moves to the sample cup 10 to suck the sample into the pipette tip 56, then moves to the top of the removed glass slide 54 and discharges the sample in the pipette tip 56 onto the glass slide 54, and finally moves to the waste collection mechanism 8 to drop the used pipette tip 56 into the waste collection mechanism 8; Here, it should be ensured that the capacity of the pipette tip 56 used is greater than the capacity of the sample to be aspirated, so that the sample aspirated from the sample cup 10 is located within the pipette tip 56, avoiding aspiration of the sample into the pipetting assembly 610 itself, and preventing the pipetting assembly 610 itself from being contaminated for subsequent reuse; Process 4: The glass slide grabbing assembly 65 transfers the glass slide 54 carrying the sample to the detection mechanism 9; In process five, the testing mechanism 9 tests the sample on the glass slide 54; the testing items include observing the sample and / or obtaining an image / video of the sample; Process 6: The glass slide grabbing assembly 65 transfers the glass slide 54 that has completed the inspection to the waste collection mechanism 8; Process seven: The sample cup 10 that has completed the test is transported to the outside of the box 1 by the transport mechanism 2 .

[0039] The order of processes 1 to 7 is not strict. For example, before executing process 1, the pipetting component 610 in the sampling mechanism 6 in process 2 and / or process 3 can be moved to the consumables storage mechanism 5 to install the gun tip 56.

[0040] The present invention uses a conveying mechanism 2 to complete the entry and exit of the sample cup 10 in the box 1, and uses a pipetting component 610 to ensure that the volume of the sample sucked each time and / or the sample used for testing is consistent. Disposable glass slides 54 and gun tips 56 are used to avoid contamination between samples, thereby improving detection efficiency and ensuring the accuracy of detection results.

[0041] As mentioned above, the sampling mechanism 6 of the present invention includes a glass slide grabbing component 65 and a liquid transfer component 610. As an optional embodiment, Figure 2 、 Figure 3 and Figure 5 As shown, the sampling mechanism 6 may include a first transverse moving assembly 61 mounted on the housing 1 and capable of reciprocating along the Y-axis, a first longitudinal moving assembly 62 mounted on the right side of the first transverse moving assembly 61 and capable of reciprocating along the X-axis, a first vertical moving assembly 63 mounted on the first longitudinal moving assembly 62 and capable of reciprocating along the Z-axis, a first rotating assembly 64 mounted on the first vertical moving assembly 63 and capable of rotating about the Z-axis, a second longitudinal moving assembly 67 mounted on the left side of the first transverse moving assembly 61 and capable of reciprocating along the X-axis, a second vertical moving assembly 68 mounted on the second longitudinal moving assembly 67 and capable of reciprocating along the Z-axis, and a second rotating assembly 69 mounted on the second vertical moving assembly 68 and capable of rotating about the X-axis. The slide grabbing assembly 65 is mounted on the first rotating assembly 64, and the pipetting assembly 610 is mounted on the second rotating assembly 69.

[0042] The glass slide grabbing assembly 65 and the pipetting assembly 610 share the first lateral moving assembly 61 to achieve reciprocating movement in the Y-axis direction to simplify the structure.

[0043] The first transverse movement assembly 61, the first longitudinal movement assembly 62, the first vertical movement assembly 63, the second longitudinal movement assembly 67, and the second vertical movement assembly 68 can be motor-screw transmission mechanisms, gear rack transmission mechanisms, belt transmission mechanisms, telescopic mechanisms such as electric cylinders, pneumatic cylinders, and hydraulic cylinders, or other mechanisms capable of linear reciprocating movement. The first rotation assembly 64 and the second rotation assembly 69 can be implemented by mounting a motor on the first vertical movement assembly 63 and the second vertical movement assembly 68, and then mounting the slide grabbing assembly 65 and the liquid transfer assembly 610 on the motor's rotating shaft.

[0044] The above-mentioned mechanism capable of achieving reciprocating motion on the X, Y, and Z axes can also be configured with reference to the relevant contents in CN223027687U.

[0045] Optionally, the slide gripping assembly 65 includes a suction cup. A pneumatic control system provides negative suction to the suction cup to securely grip the slide 54. The pneumatic control system adjusts the pressure inside and outside the suction cup to release the slide 54. Two suction cups can be provided to grip the two ends of the slide 54. Even if a sample is placed in the middle of the slide 54, this will not affect the suction cup's grip on the slide 54.

[0046] Optionally, the pipetting assembly 610 includes a channel and an air pressure control system, with a tip at the end of the channel for mounting a gun tip 56. The air pressure control system provides negative pressure to the channel and the gun tip 56 connected to the channel to draw the sample into the gun tip 56. The negative pressure in the channel and the gun tip 56 connected to the channel needs to be precisely controlled to prevent the sample from being drawn into the channel; the air pressure control system adjusts the pressure in the channel and the gun tip 56 connected to the channel to expel the sample from the gun tip 56.

[0047] The pipetting assembly 610 can also be directly configured as a pipette, and is equipped with a first drive mechanism for driving the pipette to draw and discharge liquid, and a second drive mechanism for driving the pipette to remove the tip 56. The first drive mechanism is used to press a control button on the pipette to draw and discharge the desired volume of sample, and the second drive mechanism is used to press a tip 56 ejection button on the pipette to eject the tip 56. The first drive mechanism and the second drive mechanism can be any of a pneumatic cylinder, an electric cylinder, and a hydraulic cylinder.

[0048] The pipetting assembly 610 can also be equipped with the pipetting air pump ADP1000 produced by Shenzhen Daken Technology Co., Ltd. to meet the needs. (See http: / / www.daken-tech.com / ProductDetail / 9275599.html) The gun tip 56 used in the present invention is a gun tip 56 used with conventional pipettes. Therefore, when the pipette assembly 610 includes a channel and an air pressure control system, the end of the channel for mounting the gun tip 56 has the same structure as that used at the end of conventional pipettes. If the gun tip 56 needs to be removed, a gun tip removal mechanism, such as a slot, can be provided on the waste collection mechanism 8. The pipette assembly 610 and gun tip 56 are then moved to the waste collection mechanism 8, where the gun tip 56 is locked in the slot. The pipette assembly 610 is then moved to cause the gun tip 56 to fall from the pipette assembly 610 and into the waste collection mechanism 8. If the pipette assembly 610 is a pipette, the pipette and gun tip 56 are moved to the waste collection mechanism 8, and the second drive mechanism is used to squeeze the gun tip 56 release button, causing the gun tip 56 to fall from the pipette into the waste collection mechanism 8.

[0049] like Figure 9As shown, the consumables storage mechanism 5 may include a first base 51 and a slide box 53 and a tip box 55 disposed on the first base 51. Multiple slides 54 may be stacked in the slide box 53, and a slide grabbing assembly 65 may sequentially remove the slides 54 from the top of the slide box 53. Multiple tips 56 may be neatly arranged in the tip box 55, with the tips 56 positioned vertically so that the mounting end of the tips 56 is located at the top, facilitating mounting of the tips 56 by the pipetting assembly 610.

[0050] The first base 51 and the box body 1 can be slidably connected by, for example, a slide rail 52, so that the entire consumables storage mechanism 5 can slide in the front and rear directions relative to the box body 1. The consumables storage mechanism 5 can be pulled out of the box body 1 to add glass slides 54 and gun tips 56, and the consumables storage mechanism 5 can be pushed into the box body 1 for testing.

[0051] The waste collection mechanism 8 may include a second base and a slide collection box and a gun tip collection box arranged on the second base. The slides 54 that have completed the test are placed in the slide collection box, and the used gun tips 56 are placed in the gun tip collection box to achieve classified collection of waste.

[0052] Optionally, the second base and the box body 1 can also be slidably connected by, for example, a slide rail, so that the entire waste collection mechanism 8 can slide in the front and rear directions relative to the box body 1. The waste collection mechanism 8 can be pulled out of the box body 1 to clean the collected glass slides 54 and gun tips 56, and the waste collection mechanism 8 can be pushed into the box body 1 to continue collecting glass slides 54 and gun tips 56.

[0053] As an optional implementation, Figure 1 and Figure 2 As shown, the present invention may further include a sample cup transport mechanism 3 and a sample cup placement mechanism 4 provided in the box body 1 .

[0054] Among them, such as Figure 3 and Figure 4 As shown, the sample cup transport mechanism 3 includes a clamping mechanism 34, which has multiple degrees of freedom, including at least translational freedom for reciprocating linear motion in the X, Y, and Z axes, so as to realize operations including transferring the sample cup 10 from the conveying mechanism 2 to the sample cup placement mechanism 4, or transferring the sample cup 10 that has completed testing from the sample cup placement mechanism 4 to the conveying mechanism 2.

[0055] The present invention can transfer a sample cup 10 delivered by the conveying mechanism 2 to the sample cup placement mechanism 4 for temporary storage and further processing via the sample cup transport mechanism 3, thereby facilitating subsequent liquid extraction by the liquid transfer assembly 610. After the sample cup 10 has completed testing, the sample cup transport mechanism 3 can transfer the sample cup 10 from the sample cup placement mechanism 4 to the conveying mechanism 2 and deliver it. The sample cup placement mechanism 4 can temporarily store and process multiple sample cups 10 at a time, thereby improving testing efficiency.

[0056] Optional, such as Figure 4 As shown, the sample cup transport mechanism 3 may include a second lateral moving component 31 mounted on the box body 1 and capable of reciprocating along the Y axis, a third longitudinal moving component 32 mounted on the second lateral moving component 31 and capable of reciprocating along the X axis, a third vertical moving component 33 mounted on the third longitudinal moving component 32 and capable of reciprocating along the Z axis, and a clamping mechanism 34 mounted on the third vertical moving component 33.

[0057] The second transverse moving assembly 31, the third longitudinal moving assembly 32, and the third vertical moving assembly 33 can also be a motor screw transmission mechanism, a gear rack transmission mechanism, a belt transmission mechanism, an electric cylinder / pneumatic cylinder / hydraulic cylinder and other telescopic mechanisms or other mechanisms that can achieve linear reciprocating movement.

[0058] The clamping mechanism 34 may include two openable and closable jaws, a gear may be installed on the rotating shaft of the motor, a support with two parallel slide grooves is connected to the motor, a rack is slidably installed in the slide groove, so that the two racks are simultaneously meshed with the gear and are arranged on both sides of the gear, and the two jaws are respectively connected to the two racks, thereby realizing the synchronous opening and closing of the two jaws.

[0059] The above-mentioned clamping mechanism 34 can also be configured with reference to the relevant contents in CN223027687U.

[0060] As an optional implementation, Figure 7 and Figure 8 As shown, the sample cup placement mechanism 4 may include a base plate 41 , a placement platform 48 and a weighing assembly 42 .

[0061] The bottom plate 41 and the placement platform 48 are both horizontally arranged. The bottom plate 41 is mounted on the box body 1, and the placement platform 48 is located above the bottom plate 41. The placement platform 48 has multiple placement seats 49 for storing weighed sample cups 5. Optionally, the placement seats 49 can be formed by an upwardly protruding annular structure from the placement platform 48 itself, forming a cup holder, and a through hole can be provided in the center of the cup holder to reduce weight.

[0062] Weighing assembly 42 includes a load cell 43 and a tray 44 connected to load cell 43. The lower end of load cell 43 is mounted on base plate 41, and tray 44 is mounted on the upper end of load cell 43. The placement platform 48 has a through-hole for tray 44 to pass through. Tray 44 can pass through the through-hole and protrude from the upper surface of placement platform 48, facilitating placement of sample cup 5 on tray 44 for weighing by load cell 43. Load cell 43 can be selected from the SP4M series from HBM Germany to meet requirements.

[0063] The clamping mechanism 34 can also transfer the sample cup 10 from the conveying mechanism 2 to the weighing assembly 42 for weighing, transfer the weighed sample cup 10 from the weighing assembly 42 to the placement seat 49, or transfer the tested sample cup 10 from the placement seat 49 to the conveying mechanism 2.

[0064] The present invention can weigh the sample cup 5 through the weighing component 42 to know how much sample is contained in the sample cup 5 so as to determine the amount of reagent to be added subsequently.

[0065] Some samples require the addition of reagents during testing. Figure 9 As shown, a reagent bottle 57 can also be stored in the consumable storage mechanism 5 , and the pipetting component 610 can also absorb the reagent from the reagent bottle 57 into the gun head 56 and discharge the reagent into the sample cup 10 .

[0066] The gun tip 56 for adding reagents and the gun tip 56 for drawing samples are both disposable and will be thrown away after use. They will not be mixed to avoid contamination and affect the test results.

[0067] like Figure 8 As shown, the sample cup placement mechanism 4 may further include a vibration mechanism 47. The vibration mechanism 47 cooperates with the placement platform 48 to apply an excitation force to the sample cup 5 placed in the placement seat 49. For example, the vibration mechanism 47 includes a motor mounted on the base plate 41 and a paddle mounted on the motor shaft. The vibration mechanism 47 is entirely located below the placement platform 48. When the motor rotates, the paddle strikes the placement platform 48 to apply an excitation force, causing the sample cup 5 in the placement seat 49 to vibrate. As a result, the sample in the sample cup 5 is evenly mixed under the action of the excitation force and flows downward from the cup wall to be concentrated at the bottom of the sample cup 5 for subsequent liquid collection.

[0068] The sample cup placement mechanism 4 may further include elastic reset members 46, with multiple elastic reset members 46 dispersedly disposed between the placement platform 48 and the base plate 41. The elastic reset members 46 may be springs or elastic rubber columns, with their lower ends connected to the upper surface of the base plate 41 and their upper ends connected to the lower surface of the placement platform 48. The elastic reset members 46 can provide elastic reset force for the placement platform 48, keeping the placement platform 48 horizontal during the placement of the sample cup 5 in the placement seat 49, and particularly quickly restoring the balance and horizontality of the placement platform 48 when the vibration mechanism 47 applies an excitation force to the placement platform 48.

[0069] The sample cup placement mechanism 4 may also include a detection sensor 45. Each placement seat 49 may be provided with a detection sensor 45 to detect whether a sample cup 5 is stored therein. The detection sensor 45 can also count the number of sample cups 5 placed on the placement platform 48. The detection sensor 45 may be mounted on the base plate 41, with detection light emitted upward through a through-hole in the center of the cup seat. Laser sensors may be used to meet specific requirements.

[0070] In the present invention, after the sample cup 10 containing the sample is transferred to the sample cup placement mechanism 4 by the sample cup transport mechanism 3, a small and quantitative amount of the sample can be removed from the sample cup 5 by the pipetting assembly 610 and discharged onto the glass slide 54, which is removed by the glass slide grabbing assembly 65 and placed on the detection mechanism 9 for observation. The detection mechanism 9 then observes the sample and / or obtains an image / video of the sample to determine the nature of the sample and whether reagent addition is necessary. For example, if the number of samples per unit area is excessive, exceeding the number suitable for viewing, or if there is overlap or intersection between the samples, then the sample is too thick and a diluent needs to be added. Conversely, if there is no overlap or intersection between the samples per unit area and the state of the sample can be clearly observed, then the sample concentration is appropriate and no further diluent needs to be added.

[0071] If no reagent needs to be added, the observation result of the sample and / or the image / video of the sample obtained by the detection mechanism 9 is used as the detection result information and can be output externally.

[0072] If reagents need to be added, for example, if the sample is too thick to be detected by the detection mechanism 9, the sample needs to be diluted. In this case, the slide 54 carrying the sample is first discarded into the waste collection mechanism 8 via the slide grabbing assembly 65, and a new slide 54 is grabbed and placed in the detection mechanism 9. The pipetting assembly 610 then replaces the pipette tip 56 with a new one, draws the diluent from the reagent bottle 57, and discharges it into the sample cup 10 on the sample cup placement mechanism 4. Wait for the diluent and sample to be fully and evenly mixed, or activate the vibration mechanism 47 to accelerate the mixing of the diluent and sample. After the diluent and sample are evenly mixed, the pipetting assembly 610 replaces the pipette tip 56 with a new one, draws the resulting solution (hereinafter referred to as the mixed solution) from the sample cup 10 into the pipette tip 56, and then discharges the mixed solution onto the slide 54 on the detection mechanism 9 for observation. The detection mechanism 9 then observes the sample and / or captures an image / video of the sample, thereby obtaining test results and information, which can be output externally. During this process, the amount of reagent required to be added is determined by weighing the sample cup 5 by the weighing component 42 and taking into account the properties of the sample. The purpose of adding the reagent is to enable the detection mechanism 9 to clearly observe the sample and / or obtain a clear image / video of the sample. Therefore, the amount of the added reagent is not required to be very accurate and can fluctuate within a certain range.

[0073] As an optional implementation, Figure 6 As shown, the present invention further includes a slide placement table 7 provided in the box 1. Figure 5 As shown, the slide grabbing assembly 65 can also be provided with a sample property determination assembly 66. The slide grabbing assembly 65 can also remove the slide 54 from the consumables storage mechanism 5 and transfer it to the slide placement table 7 so that the pipetting assembly 610 can aspirate the sample from the sample cup 10 and discharge the sample onto the slide 54 placed on the slide placement table 7. The sample property determination assembly 66 can also determine the properties of the sample to determine whether reagents need to be added.

[0074] The slide placement table 7 has a platform, boss or groove for placing the slide 54. The surface of the slide placement table 7 is made of a pure single-color material, preferably a non-transparent material that is non-reflective. For example, a smooth metal surface is sprayed with uniform black paint and the paint surface is polished smooth to facilitate the sample property judgment component 66 to judge the properties of the sample on the slide 54 placed thereon.

[0075] The sample property judgment component 66 can use an industrial camera or other component capable of capturing sample images / videos to obtain clear images / videos, and observe changes in the sample's properties by comparing them before and after. For example, when it is necessary to determine whether to add a diluent based on the sample's consistency, a small and quantitative amount of the sample can be taken onto a glass slide 54 placed on a glass slide placement table 7. The sample property judgment component 66 can then observe the diffusion area of ​​the sample on the glass slide 54 after a certain period of time to determine the sample's consistency. If the diffusion area is less than the preset value, it indicates that the sample is too thick and is not conducive to direct detection of the sample by the detection mechanism 9, and a diluent needs to be added. If the diffusion area is greater than or equal to the preset value, it indicates that the sample's consistency is appropriate and can be directly detected by the detection mechanism 9, without the need for a diluent.

[0076] As an optional embodiment, the glass slides 54 stored in the consumables storage mechanism 5 may include glass slides with test papers and ordinary glass slides.

[0077] At this time, the glass slide grabbing component 65 can take out the glass slide with the test paper from the consumables storage mechanism 5 and transfer it to the glass slide placement table 7 so that the sample can be sucked from the sample cup 10 by the pipetting component 610 and the sample can be discharged onto the glass slide with the test paper placed on the glass slide placement table 7 to react with the sample carried thereon, and the sample property judgment component 66 can judge the property of the sample to determine whether reagents need to be added. Alternatively, the glass slide grabbing component 65 can take out the ordinary glass slide from the consumables storage mechanism 5 and transfer it to the detection mechanism 9 so that the sample or the mixture of the sample and the reagent can be sucked from the sample cup 10 by the pipetting component 610 and the sample or the mixture can be discharged onto the ordinary glass slide on the detection mechanism 9.

[0078] Optionally, two slide boxes 53 are provided on the consumables storage mechanism 5 , wherein one slide box 53 is used to store slides with test papers, and the other slide box 53 is used to store ordinary slides.

[0079] The glass slide with the test paper can be a regular glass slide with a test paper attached. The test paper can react with the sample to determine the properties of the sample. For example, to determine the consistency of the sample, the test paper can be pH test paper. The sample is dropped onto the middle of the pH test paper. The sample's diffusion on the pH test paper over a certain period of time is observed (primarily observing the diffusion of the sample droplet along the length of the pH test paper) to determine the sample's consistency. If the diffusion is less than a preset value, the sample is too thick and is not suitable for direct detection by the detection mechanism 9, requiring the addition of a diluent. If the diffusion is greater than or equal to the preset value, the sample's consistency is appropriate and can be directly detected by the detection mechanism 9 without the need for a diluent.

[0080] The present invention may further include a temperature detection component and a temperature adjustment component within the housing 1. The temperature detection component may be a temperature sensor, preferably mounted on the sample cup placement mechanism 4. The temperature detection component is used to detect the temperature within the housing 1 to prevent the sample from being in an environment with excessively low or high temperatures that would affect its activity. The temperature adjustment component may be a device capable of adjusting temperature, such as an air conditioner. Since biological fluid samples (such as semen) are in a constant temperature state within the body (for example, human body temperature is typically between 36°C and 38°C) and are higher than room temperature, the temperature adjustment component may also be a device capable of only heating air, such as a hot air blower, to adjust the temperature within the housing 1 to a temperature environment where the biological fluid sample can maintain normal activity, thereby improving the accuracy of the test results.

[0081] Since the present invention can test multiple samples at once, to facilitate identification of sample sources and recording of individual sample information, a graphically coded identifier, such as a QR code or barcode, recording information such as the source and sampling time, can be affixed to the sample cup 10. A barcode scanning component, such as a barcode scanner, is also provided within the housing 1. This component, preferably a barcode scanner gun, is preferably mounted near the input end of the conveyor mechanism 2 to read the graphically coded identifier information on the sample cup 10 and output it together with the information detected by the detection mechanism 9.

[0082] In the present invention, the installation position of each mechanism can be adjusted as needed. Figure 1 and Figure 2 As shown, the sample cup transport mechanism 3 and the sampling mechanism 6 are installed at the upper part of the interior of the box body 1 , and the sample cup transport mechanism 3 is arranged on the left side of the sampling mechanism 6 .

[0083] like Figure 6 As shown, the conveying mechanism 2, the sample cup placement mechanism 4, the consumables storage mechanism 5, the slide placement table 7, the waste collection mechanism 8, and the detection mechanism 9 are all installed in the lower part of the interior of the box body 1. Among them, the conveying mechanism 2 is arranged on the left side, the rear side, and the front side. The sample cup placement mechanism 4 is arranged on the right side of the left conveying mechanism 2, the consumables storage mechanism 5 and the slide placement table 7 are arranged on the right side of the sample cup placement mechanism 4, and the consumables storage mechanism 5 is arranged in front of the slide placement table 7. The waste collection mechanism 8 is arranged on the right side of the consumables storage mechanism 5, the detection mechanism 9 is arranged on the right side of the slide placement table 7, and the waste collection mechanism 8 is arranged in front of the detection mechanism 9. The waste collection mechanism 8 and the detection mechanism 9 are both arranged on the left side of the right conveying mechanism 2. In addition, the sample cup placement mechanism 4, the consumables storage mechanism 5, the slide placement table 7, the waste collection mechanism 8, and the detection mechanism 9 are all arranged in front of the rear conveying mechanism 2.

[0084] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0085] The above preferred embodiments should not be construed as limiting the present invention. The scope of protection of the present invention should be determined by the scope defined in the claims. Persons skilled in the art will appreciate that improvements and modifications may be made without departing from the spirit and scope of the present invention, and such improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A biological fluid sample detection device, characterized in that: It comprises a box body (1) and a conveying mechanism (2), a consumable material storage mechanism (5), a sampling mechanism (6), a waste collection mechanism (8) and a detection mechanism (9) arranged in the box body (1); The box (1) is provided with an inlet and an outlet corresponding to the input end and the output end of the conveying mechanism (2), respectively; the conveying mechanism (2) is used to convey the sample cup (10) containing the sample into the box (1), or to convey the sample cup (10) that has completed the test out of the box (1); The consumable material storage mechanism (5) stores a glass slide (54) and a gun tip (56); The sampling mechanism (6) includes a glass slide grabbing component (65) and a liquid transfer component (610); The glass slide grabbing assembly (65) has multiple degrees of freedom to remove the glass slide (54) from the consumable material storage mechanism (5), transfer the removed glass slide (54) to the detection mechanism (9), or transfer the glass slide (54) that has completed the detection from the detection mechanism (9) to the waste collection mechanism (8); The pipetting assembly (610) has multiple degrees of freedom to install a gun tip (56) in a consumable storage mechanism (5), draw a sample from a sample cup (10) into the gun tip (56) and discharge the sample onto a removed glass slide (54), or drop a used gun tip (56) into a waste collection mechanism (8); The detection mechanism (9) is used to detect the sample carried on the glass slide (54).

2. The biological fluid sample detection device according to claim 1, characterized in that: It also includes a sample cup transport mechanism (3) and a sample cup placement mechanism (4) disposed in the box (1); The sample cup transport mechanism (3) includes a clamping mechanism (34) with multiple degrees of freedom for transferring a sample cup (10) from a conveying mechanism (2) to a sample cup placement mechanism (4), or transferring a sample cup (10) that has completed testing from the sample cup placement mechanism (4) to the conveying mechanism (2).

3. The biological fluid sample detection device according to claim 2, characterized in that: The sample cup placement mechanism (4) includes a weighing component (42) and a placement seat (49); The clamping mechanism (34) can also transfer the sample cup (10) from the conveying mechanism (2) to the weighing assembly (42) for weighing, transfer the weighed sample cup (10) from the weighing assembly (42) to the placement seat (49), or transfer the tested sample cup (10) from the placement seat (49) to the conveying mechanism (2); The consumable material storage mechanism (5) further stores a reagent bottle (57); the pipetting assembly (610) is further capable of drawing the reagent from the reagent bottle (57) into the gun tip (56) and discharging the reagent into the sample cup (10).

4. The biological fluid sample detection device according to claim 3, characterized in that: The sample cup placement mechanism (4) further includes a vibration mechanism (47); the vibration mechanism (47) is linked with the placement seat (49) to apply an exciting force to the placement seat (49).

5. A biological fluid sample detection device according to claim 3 or 4, characterized in that: It also includes a slide placement table (7) provided in the box (1); The slide grabbing component (65) is also provided with a sample property determination component (66); The glass slide grabbing assembly (65) can also remove the glass slide (54) from the consumables storage mechanism (5) and transfer it to the glass slide placement table (7) so that the sample can be sucked from the sample cup (10) by the pipetting assembly (610) and discharged onto the removed glass slide (54), and the sample property judgment assembly (66) can judge the properties of the sample to determine whether reagents need to be added.

6. The biological fluid sample detection device according to claim 5, characterized in that: The glass slides (54) stored in the consumable material storage mechanism (5) include glass slides with test paper and ordinary glass slides; The glass slide grabbing assembly (65) can take out the glass slide with the test paper from the consumable material storage mechanism (5) and transfer it to the glass slide placement table (7) so that the sample can be sucked from the sample cup (10) by the pipetting assembly (610) and the sample can be discharged onto the glass slide with the test paper to react with the sample carried thereon, and the sample property judgment assembly (66) can judge the property of the sample to determine whether a reagent needs to be added. Alternatively, the glass slide grabbing assembly (65) can take out the ordinary glass slide from the consumable material storage mechanism (5) and transfer it to the detection mechanism (9) so that the sample or a mixture of the sample and the reagent can be sucked from the sample cup (10) by the pipetting assembly (610) and the sample or the mixture can be discharged onto the ordinary glass slide on the detection mechanism (9).

7. The biological fluid sample detection device according to claim 1, characterized in that: The sampling mechanism (6) further comprises a first driving mechanism for driving the pipetting assembly (610) to take and discharge liquid, and a second driving mechanism for driving the pipetting assembly (610) to detach the gun tip (56).

8. The biological fluid sample detection device according to claim 1, wherein: The consumable material storage mechanism (5) and the waste collection mechanism (8) are both slidably arranged on the box body (1) to move in and out relative to the box body (1).

9. The biological fluid sample detection device according to claim 1, wherein: A temperature detection component and a temperature adjustment component are also provided in the box (1).

10. The biological fluid sample detection device according to claim 1, characterized in that: The box (1) is also provided with a code scanning component for reading the graphic code identification information on the sample cup (10).

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