Method for detecting pressure in intracranial aneurysm cavity

Abstract

The invention provides a method for detecting pressure in an intracranial aneurysm cavity, and belongs to the technical field of pressure detection in an aneurysm cavity. The detection method comprises the following steps: S1, planning an implantation path, positioning an aneurysm focus position under the guidance of image equipment before an operation, and planning the implantation path of a pressure monitoring system; s2, a pressure monitoring system is implanted, a guide catheter is intervened through femoral artery puncture, and the pressure monitoring system is sent to a target blood vessel section; s3, data are collected, and pressure values in the aneurysm cavity and the aneurysm neck opening are collected before the operation, during the operation and after the operation respectively; s4, data analysis: analyzing the collected data so as to respectively determine changes of pressure values in the aneurysm cavity and the aneurysm neck opening before, during and after an operation; the method is mainly used for solving the technical problems that in the prior art, real-time monitoring means for the pressure of an aneurysm cavity is lacked, and the force change in the aneurysm cavity cannot be accurately measured.

Description

Technical Field

[0001] The present invention belongs to the technical field of aneurysm intracavity pressure detection, and in particular relates to a method for detecting intracavity pressure of an intracranial aneurysm. Background Art

[0002] An intracranial aneurysm is a tumor-like bulge caused by the abnormal, localized expansion of a cerebral artery wall. It is not a true tumor, but rather a vascular disease. It most commonly occurs in the basilar arterial circle (Circle of Willis) and its branches. Due to the weakened vessel wall, it gradually bulges under the impact of blood flow, resembling a "balloon" on the vessel wall. Unruptured aneurysms have a good prognosis with prompt treatment, and most patients can lead a normal life. However, ruptured aneurysms can cause subarachnoid hemorrhage, a serious and potentially life-threatening condition.

[0003] Existing clinical evaluation methods mainly rely on imaging examinations and hemodynamic simulations. They lack real-time monitoring of the intracavitary pressure of the aneurysm and cannot dynamically reflect the actual pressure-bearing state of the aneurysm, nor can they determine the risk of rupture in a short period of time. Especially after coil packing surgery, existing evaluation methods cannot accurately assess the surgical effect, and thus cannot correctly guide the next step of treatment direction.

[0004] Therefore, it is necessary to provide an improved technical solution to the above-mentioned deficiencies in the prior art. Summary of the Invention

[0005] The purpose of the present invention is to provide a method for detecting the pressure within the aneurysm cavity of an intracranial aneurysm, so as to solve the technical problems existing in the prior art of lacking a means for real-time monitoring of the aneurysm cavity pressure and being unable to accurately measure the changes in aneurysm pressure.

[0006] In order to achieve the above-mentioned object, the method for detecting the intracavitary pressure of an intracranial aneurysm of the present invention provides the following technical solutions:

[0007] A method for detecting intracavitary pressure of an intracranial aneurysm comprises the following steps:

[0008] S1, planning the implantation path: locating the aneurysm lesion under the guidance of imaging equipment before surgery, and planning the implantation path of the pressure monitoring system;

[0009] S2, implanting the pressure monitoring system, inserting the guide catheter through the femoral artery, and delivering the pressure monitoring system to the target vascular segment;

[0010] S3, data collection, collecting pressure values ​​inside the aneurysm cavity and at the aneurysm neck before, during, and after the operation;

[0011] S4, data analysis, analyzes the collected data to determine the changes in the pressure values ​​within the aneurysm cavity and at the neck of the aneurysm before, during, and after the operation.

[0012] As a further optimized technical solution, the pressure monitoring system includes a signal acquisition module, a signal processing module and a signal display module. The signal acquisition module includes an implantable microcatheter. A first pressure sensor is provided at the distal end of the implantable microcatheter for collecting the pressure inside the aneurysm cavity. A second pressure sensor is provided at a set distance from the first pressure sensor for collecting the pressure at the neck of the aneurysm. The signal processing module is provided at the proximal end of the implantable microcatheter and is electrically connected to the first pressure sensor and the second pressure sensor to synchronously process the collected data. The signal display module is electrically connected to the signal processing module for displaying the processed data.

[0013] As a further optimized technical solution, in step S2, the distal end of the implantable microcatheter of the pressure monitoring system is advanced into the aneurysm cavity, and the position of the distal end of the implantable microcatheter is adjusted to ensure that the first pressure sensor is located in the aneurysm cavity and the second pressure sensor is located in the arterial segment outside the aneurysm neck.

[0014] As a further optimized technical solution, the distal end of the implantable microcatheter has a plurality of self-expandable measuring branches, and a first pressure sensor is arranged at the distal end of each measuring branch.

[0015] As a further optimized technical solution, the lengths of the multiple measurement branches are different so as to collect pressure values ​​in the aneurysm cavity from different positions.

[0016] As a further optimized technical solution, in step S2, the pressure inside the aneurysm cavity collected is the average value of data collected by multiple first pressure sensors.

[0017] As a further optimized technical solution, the pressure monitoring system further includes a temperature compensation module for correcting the temperature drift error of the signal acquisition module.

[0018] As a further optimized technical solution, the method for correcting the temperature drift error by the temperature compensation module includes: under a set test environment, establishing a multi-point temperature-pressure offset model of the first pressure sensor and the second pressure sensor respectively, and bringing the data collected in the body into the offset model for correction to reduce the impact of temperature on the collected pressure value.

[0019] As a further optimized technical solution, in step S4, when analyzing the collected data, the ratio or pressure difference between the pressure inside the aneurysm cavity and the pressure at the aneurysm neck after each data collection is analyzed.

[0020] As a further optimized technical solution, the pressure monitoring system also includes an early warning module, which is electrically connected to the signal processing module and is used to compare the results of data processing with a preset threshold value, and trigger an early warning when the preset threshold value is exceeded.

[0021] Beneficial effects: In the present invention, by implanting a pressure monitoring system, the pressure inside the aneurysm cavity and at the neck of the aneurysm can be monitored in real time. Compared with existing imaging examinations and hemodynamic simulation evaluation methods, the pressure values ​​inside the aneurysm cavity and at the neck of the aneurysm can be accurately collected, and the pressure status inside the aneurysm cavity can be obtained more accurately, which makes up for the deficiency of the existing technology in lacking real-time monitoring means and dynamically reflects the actual pressure status of the aneurysm.

[0022] Furthermore, this detection method, with the help of the implantable microcatheter in the signal acquisition module, can obtain pressure data from different positions inside the aneurysm cavity through the distal first pressure sensor and multiple self-expandable measurement branches, and significantly improve the data accuracy by taking the average value of multiple first pressure sensors; the second pressure sensor accurately collects the pressure of the aneurysm neck, and cooperates with the synchronous processing of the signal processing module to achieve high-precision real-time monitoring of the pressure inside the aneurysm cavity, which can dynamically reflect the actual pressure changes of the tumor under different physiological states, and provide more comprehensive and accurate data support for clinical diagnosis.

[0023] Furthermore, during coil packing surgery to treat intracranial aneurysms, existing evaluation methods are difficult to accurately judge the effectiveness of the surgery. This method continuously collects and analyzes the pressure values ​​of the aneurysm cavity and the aneurysm neck before, during, and after the surgery, and compares the changing trends, ratios, or differences of the pressure values. This method can intuitively reflect the impact of the surgery on the aneurysm pressure distribution, effectively evaluate the stability of the aneurysm after coil packing, and provide a reliable basis for doctors to judge whether the surgery has achieved the expected results and whether the treatment strategy needs to be adjusted, greatly improving the accuracy and scientific nature of the surgical effect evaluation.

[0024] Furthermore, the introduction of the temperature compensation module in the pressure monitoring system establishes a multi-point temperature-pressure offset model based on the first pressure sensor and the second pressure sensor in vitro. This model can accurately correct the temperature drift error caused by temperature changes during the in vivo pressure acquisition process, effectively eliminate the interference of environmental factors on the data, ensure that the collected pressure data is true and reliable, provide a data basis for subsequent data analysis and clinical decision-making, and reduce the risk of misdiagnosis due to data errors.

[0025] Furthermore, the early warning module works closely with the signal processing module to preset reasonable pressure thresholds based on a large amount of clinical data and professional medical knowledge. During real-time data analysis, once the aneurysm pressure value or pressure ratio is detected to exceed the preset threshold, the early warning module will quickly trigger an alarm and promptly notify medical staff through visual or sound prompts. This intelligent early warning mechanism can help doctors detect the increased risk of aneurysm rupture in the first place, gain precious time for emergency intervention and treatment, significantly improve the patient's treatment success rate, and ensure the patient's life safety.

[0026] Furthermore, by combining the comprehensive, accurate and real-time aneurysm pressure data obtained through this detection method with early warning information, doctors can gain a deeper understanding of the patient's disease progression. Based on this, they can formulate more personalized and targeted treatment plans, reasonably arrange the time and means of subsequent treatment, avoid over-treatment or under-treatment, optimize the entire treatment decision-making process, enhance the comprehensive treatment level of intracranial aneurysms, and improve patient prognosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The drawings and the accompanying drawings, which constitute part of this application, are intended to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are intended to explain the present invention and do not constitute an undue limitation of the present invention. Among them:

[0028] Figure 1 This is a flow chart of a method for detecting intracavitary pressure of an intracranial aneurysm according to one embodiment of the present invention;

[0029] Figure 2 Schematic diagram of a method for detecting intracavitary pressure of an intracranial aneurysm according to an embodiment of the present invention.

[0030] In the figure: 1. Guide catheter; 2. Aneurysm; 3. Signal acquisition module; 301. Implantable microcatheter; 3011. Measurement branch; 302. First pressure sensor; 303. Second pressure sensor; 4. Signal processing module; 5. Signal display module; 6. Blood vessel. DETAILED DESCRIPTION

[0031] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field are within the scope of protection of the present invention.

[0032] In the description of the present invention, the terms "longitudinal", "transverse", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and do not require that the present invention must be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present invention. The terms "connected" and "connected" used in the present invention should be understood in a broad sense. For example, they can be fixedly connected or detachably connected; they can be directly connected or indirectly connected through an intermediate component. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances. In addition, the term "proximal end" refers to the end close to the operator, and "distal end" refers to the end away from the operator.

[0033] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments. It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other.

[0034] The shapes and sizes of the components in the drawings do not reflect the actual proportions of the products, and are only intended to illustrate the contents of the present invention.

[0035] The present invention provides a method for detecting the pressure of an intracranial aneurysm. The implantation path of the pressure monitoring system is planned under the guidance of an imaging device before surgery, and the system is delivered to the target vascular segment via a femoral artery puncture interventional guide catheter. The first pressure sensor at the distal end of the implanted microcatheter in the pressure monitoring system is used to collect the internal pressure of the aneurysm cavity, and the second pressure sensor collects the pressure at the neck of the aneurysm. Multiple self-expandable measurement branches assist in obtaining the pressure at multiple points in the aneurysm cavity and taking the average value. The signal processing module synchronously processes the data, and the temperature drift error is corrected in combination with the temperature compensation module. Data is collected and analyzed before, during, and after surgery, and the pressure value ratio or difference is compared. The early warning module compares the analysis results with the preset threshold value, and triggers an early warning when the threshold value is exceeded. This method realizes high-precision real-time monitoring of intracranial aneurysm pressure, accurately evaluates surgical effects, reduces data errors, provides intelligent risk warnings, optimizes treatment decisions, and improves the success rate of patient treatment. It has significant clinical application value.

[0036] Example 1

[0037] like Figure 1 、 Figure 2 As shown, a method for detecting intracranial aneurysm pressure includes the following steps:

[0038] S1, planning the implantation path. Before the operation, locate the lesion of aneurysm 2 under the guidance of imaging equipment, and plan the implantation path of the pressure monitoring system. Specifically, before the operation, use existing imaging equipment, such as CT angiography (CTA) or digital subtraction angiography (DSA), to perform a detailed scan of the patient's brain, accurately locate the lesion of aneurysm 2, and plan the optimal implantation path of the pressure monitoring system based on the specific location, shape and size of aneurysm 2 and the structure of the patient's blood vessels 6 to ensure the smooth progress of subsequent operations. For example, the operation can use bilateral femoral artery puncture, one side is used to deliver the pressure monitoring system, and the other side is used to perform a packing operation on the aneurysm 2. This can reduce mutual interference during the placement of the device and reduce the difficulty of placing the device in place.

[0039] S2, implanting the pressure monitoring system, inserting the guide catheter 1 through femoral artery puncture, and delivering the pressure monitoring system to the target blood vessel 6 segment along the previously planned path.

[0040] In this embodiment, the pressure monitoring system includes a signal acquisition module 3, a signal processing module 4 and a signal display module 5. The signal acquisition module 3 includes an implantable microcatheter 301. The distal end of the implantable microcatheter 301 has multiple self-expandable measuring branches 3011. A first pressure sensor 302 is arranged at the distal end of each measuring branch 3011. A second pressure sensor 303 is set at a set distance from the first pressure sensor 302. During the implantation process, the distal end of the implantable microcatheter 301 is pushed into the aneurysm 2 body, and the position of the distal end of the implantable microcatheter 301 is adjusted to ensure that the first pressure sensor 302 is completely located in the aneurysm 2 body, and the second pressure sensor 303 is located in the arterial segment outside the aneurysm neck 2. The first pressure sensor 302 is used to collect the pressure inside the aneurysm 2 body, and the second pressure sensor 303 is used to collect the pressure at the aneurysm neck 2. The signal processing module 4 is disposed at the proximal end of the implantable microcatheter 301 and is electrically connected to the first pressure sensor 302 and the second pressure sensor 303 to synchronously process the collected data. The signal display module 5 is electrically connected to the signal processing module 4 for displaying the processed data.

[0041] Preferably, the lengths of the multiple measurement branches 3011 are different so as to collect pressure values ​​within the aneurysm 2 from different positions. Specifically, the measurement branches 3011 of different lengths can penetrate into different areas (such as the top, side wall, and bifurcation) within the aneurysm 2, thereby forming spatially distributed pressure monitoring points, which can more comprehensively reflect the changes in the pressure gradient within the aneurysm compared to single-point measurement. In addition, the morphology of aneurysms in different patients varies significantly, and single-point measurement cannot meet personalized needs. By distributing the measurement branches 3011, this design can optimize the layout of sampling points based on the geometric characteristics of each aneurysm, provide accurate data support for material selection and packing density planning for coil embolization, and improve the success rate of the operation.

[0042] Furthermore, the pressure monitoring system includes a temperature compensation module, which is provided between the signal acquisition module 3 and the signal processing module 4 and is used to correct the temperature drift error of the signal acquisition module 3 .

[0043] The specific method for correcting temperature drift error by the temperature compensation module is as follows:

[0044] First, consider the selection of first and second pressure sensors 302 and 303: These sensors utilize integrated temperature measurement components, such as NTC thermistors or TMP117 digital temperature sensors. These components accurately sense temperature changes in the surrounding environment and the sensor itself, converting the temperature signals into recognizable electrical or digital signals, providing fundamental data for subsequent temperature-pressure offset calculations.

[0045] Secondly, establish a temperature-pressure offset model: construct a multi-point temperature-pressure offset model for each sensor under the test environment set in vitro, such as the quadratic function ΔP=aT 2 +bT+c. This model performs a large number of calibration experiments on the pressure sensor under different temperature conditions, collects data corresponding to temperature T and pressure offset ΔP, and uses mathematical fitting methods to determine the coefficients a, b, and c. For example, in a laboratory environment, the pressure sensor is placed in a constant temperature box at different temperatures (such as 25°C, 30°C, 35°C, etc.). After stabilization at each temperature point, the pressure value is measured multiple times and compared with the standard pressure value. The pressure offset data at different temperatures is obtained, and then accurate model parameters are fitted.

[0046] Real-time temperature sampling and calculation: During system operation, the MCU (microcontroller unit) controls the integrated temperature measurement element to perform temperature sampling in real time and obtain the current temperature value T. This temperature value is then substituted into the established temperature-pressure offset model ΔP = aT 2 +bT+c, calculate the offset ΔP of the pressure data at the current temperature. For example, if the current temperature T is 32°C and the model calculates ΔP as 0.5 mmHg, then the pressure sensor's measured value has an offset of 0.5 mmHg at that temperature.

[0047] Pressure Data Correction: The original collected pressure data is corrected based on the calculated offset ΔP. If the original pressure measurement is P1, the temperature-compensated pressure value P = P1 - ΔP. This eliminates measurement errors in the collected pressure values ​​due to temperature fluctuations (i.e., temperature drift errors), ensuring that the pressure data truly reflects the actual pressure conditions inside and outside the cerebral artery aneurysm cavity, keeping the measurement error within ±1 mmHg and significantly improving the accuracy and reliability of the monitoring data.

[0048] S3, collecting data, collecting pressure values ​​inside the aneurysm 2 and at the neck of the aneurysm before, during, and after the operation.

[0049] Specifically, the pressure monitoring system's signal acquisition module 3 collects data before, during, and after the tamponade procedure. A first pressure sensor 302 collects pressure data at various locations within the aneurysm 2, aggregates this data, and takes the average value as the pressure within the aneurysm 2. A second pressure sensor 303 collects pressure data at the neck of the aneurysm 2. The data collected by the signal acquisition module 3 is transmitted to the temperature compensation module, where it is corrected and transmitted in real time to the signal processing module 4.

[0050] S4, data analysis, analyzes the collected data to determine the changes in the pressure values ​​within the aneurysm body and at the aneurysm neck before, during, and after the operation.

[0051] The signal processing module 4 synchronously processes the collected data and transmits the processed data to the signal display module 5 for display, so that the doctor can analyze the displayed data. In the specific processing, it is necessary to calculate the ratio or pressure difference between the pressure inside the aneurysm 2 and the pressure at the neck of the aneurysm 2 after each data collection, and comprehensively judge the changes in the safety status of the aneurysm 2. The monitoring results of the ratio or pressure difference can reflect the following situations: for example, whether the pressure fluctuations in the aneurysm 2 are severe, whether there is increased pulsation, whether the abnormal increase in the pressure ratio indicates that the elasticity of the aneurysm wall has deteriorated or the risk of rupture has increased, whether there is local blood flow abnormality caused by stimulation of the interventional device during the operation, and whether there are signs of aneurysm refilling, regeneration or micro-exudation after the operation.

[0052] Furthermore, the pressure monitoring system includes an early warning module, which is electrically connected to the signal processing module 4 and is configured to compare the data analysis results with a preset threshold value and trigger an early warning when the threshold value is exceeded. Specifically, in this embodiment, the processed data is graphed, and the early warning module generates a pressure fluctuation chart and a real-time risk trend chart for real-time output. If the ratio or pressure difference continuously exceeds the preset threshold value, the system automatically triggers an alarm, providing doctors with timely decision-making basis.

[0053] In summary, the method for detecting the intracavitary pressure of an intracranial aneurysm provided by the present invention can achieve accurate pressure detection and timely risk warning, which helps to reduce unnecessary repeated examinations and excessive medical treatment. At the same time, accurate diagnosis of the disease and scientific formulation of treatment plans can effectively reduce the risks during surgery and subsequent treatment, reduce the probability of complications, alleviate patient suffering, improve the efficiency of medical resource utilization, and achieve accurate detection of intracavitary pressure of intracranial aneurysm and risk warning, which has important clinical application value and broad market prospects.

[0054] It will be understood that the above description is merely exemplary and the embodiments of the present application do not limit this.

[0055] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention are within the scope of protection of the pending claims of the present invention.

Claims

1. A method for detecting intracavitary pressure of an intracranial aneurysm, characterized in that: The following steps are involved: S1, planning the implantation path, locating the aneurysm (2) lesion under the guidance of imaging equipment before surgery, and planning the implantation path of the pressure monitoring system; S2, implanting a pressure monitoring system, inserting an interventional guide catheter (1) through the femoral artery, and delivering the pressure monitoring system to the target blood vessel (6) segment; S3, collecting data, collecting pressure values ​​of the aneurysm (2) cavity and aneurysm neck before, during and after the operation; S4, data analysis, analyzes the collected data to determine the changes in the pressure values ​​in the aneurysm cavity and the aneurysm neck before, during and after the operation.

2. The method for detecting intracranial aneurysm pressure according to claim 1, characterized in that: The pressure monitoring system comprises a signal acquisition module (3), a signal processing module (4) and a signal display module (5), wherein the signal acquisition module (3) comprises an implantable microcatheter (301), a first pressure sensor (302) is provided at the distal end of the implantable microcatheter (301) for collecting the pressure inside the aneurysm cavity of the aneurysm (2), a second pressure sensor (303) is provided at a set distance from the first pressure sensor (302) for collecting the pressure at the neck of the aneurysm (2), the signal processing module (4) is provided at the proximal end of the implantable microcatheter (301) and is electrically connected to the first pressure sensor (302) and the second pressure sensor (303) for synchronously processing the collected data, and the signal display module (5) is electrically connected to the signal processing module (4) for displaying the processed data.

3. The method for detecting intracranial aneurysm pressure according to claim 2, characterized in that: In step S2, the distal end of the implantable microcatheter (301) of the pressure monitoring system is advanced into the aneurysm (2) cavity, and the position of the distal end of the implantable microcatheter (301) is adjusted to ensure that the first pressure sensor (302) is located in the aneurysm (2) cavity and the second pressure sensor (303) is located in the arterial segment outside the aneurysm neck (2).

4. The method for detecting intracranial aneurysm pressure according to claim 2, wherein: The distal end of the implantable microcatheter (301) has a plurality of self-expandable measuring branches (3011), and a first pressure sensor (302) is arranged at the distal end of each measuring branch (3011).

5. The method for detecting intracranial aneurysm pressure according to claim 4, characterized in that: The lengths of the plurality of measuring branches (3011) are different so as to collect pressure values ​​in the aneurysm cavity of the aneurysm (2) from different positions.

6. The method for detecting intracranial aneurysm pressure according to claim 5, characterized in that: In step S2, the pressure inside the aneurysm cavity of the aneurysm (2) is collected as an average value of the data collected by the plurality of first pressure sensors (302).

7. The method for detecting intracranial aneurysm pressure according to claim 2, characterized in that: The pressure monitoring system further comprises a temperature compensation module for correcting the temperature drift error of the signal acquisition module (3).

8. The method for detecting intracranial aneurysm intracavity pressure according to claim 7, characterized in that: The method for correcting the temperature drift error of the temperature compensation module includes: under a set test environment, establishing a multi-point temperature-pressure offset model of the first pressure sensor (302) and the second pressure sensor (303), respectively, bringing the data collected in the body into the offset model for correction, and reducing the influence of temperature on the collected pressure value.

9. The method for detecting intracranial aneurysm pressure according to claim 4, characterized in that: In step S4, when analyzing the collected data, the ratio or pressure difference between the pressure inside the aneurysm cavity (2) and the pressure at the aneurysm neck (2) after each data collection is analyzed.

10. The method for detecting intracranial aneurysm intracavity pressure according to claim 2, characterized in that: The pressure monitoring system further comprises an early warning module, which is electrically connected to the signal processing module (4) and is used to compare the result of data processing with a preset threshold value, and trigger an early warning when the preset threshold value is exceeded.

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