Traditional Chinese medicine composition for delaying cardiovascular aging and preparation method thereof

Abstract

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 12 to 15 parts of radix astragali seu hedysari, 12 to 15 parts of radix codonopsis, 10 to 13 parts of semen ziziphi spinosae, 8 to 15 parts of rhizoma chuanxiong, 10 to 15 parts of radix puerariae, 6 to 10 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of pericarpium citri reticulatae, 5 to 9 parts of ramulus cinnamomi, 3 to 8 parts of herba lycopi and 2 to 6 parts of folium ginkgo. The traditional Chinese medicine composition is prepared according to the principle of monarch, minister, assistant and guide under the guidance of traditional Chinese medicine syndrome differentiation and disease differentiation treatment theories, is mainly used for tonifying qi, promoting blood circulation to remove blood stasis, improving blood circulation and delaying cardiovascular aging, has the effects of soothing the nerves, nourishing sleep and improving the life quality of patients, and is safe in clinical application and free of side effects.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for delaying cardiovascular aging and a preparation method thereof. Background Art

[0002] Cardiovascular aging is an important hub connecting aging and aging-related diseases. Cardiovascular aging refers to the aging of the heart and blood vessels. The antioxidant capacity of aging cells is weakened, and the elasticity of blood vessels and arterial stiffness increase, leading to many problems such as hypertension, myocardial damage, and inflammation. Patients with cardiovascular diseases are often troubled by too little sleep.

[0003] Existing Western medicines for improving cardiovascular health have obvious side effects. For example, diuretics or calcium channel blockers may cause electrolyte imbalance, increased nocturia or ankle edema in patients, affecting their sleep. Traditional Chinese medicine has unique advantages in delaying cardiovascular aging from the perspective of dialectical argumentation and holistic treatment.

[0004] Therefore, the present invention is specially proposed to solve the above technical problems. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition for delaying cardiovascular aging.

[0006] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are adopted: A traditional Chinese medicine composition for delaying cardiovascular aging, comprising the following traditional Chinese medicine raw materials in parts by weight: 12-15 parts of Astragalus, 12-15 parts of Codonopsis, 10-13 parts of Ziziphus jujuba seeds, 8-15 parts of Chuanxiong, 10-15 parts of Pueraria root, 6-10 parts of Atractylodes macrocephala, 5-10 parts of Citrus reticulata, 5-9 parts of cinnamon twig, 3-8 parts of Zedoaria, and 2-6 parts of Ginkgo biloba leaves.

[0007] Preferably, the traditional Chinese medicine composition for delaying cardiovascular aging is composed of the following traditional Chinese medicine raw materials in parts by weight: 14 parts of astragalus, 13 parts of codonopsis, 10 parts of jujube seeds, 8 parts of ligusticum, 15 parts of kudzu root, 10 parts of atractylodes, 5 parts of tangerine peel, 9 parts of cinnamon twig, 3 parts of zedoaria, and 6 parts of ginkgo leaves.

[0008] Preferably, the ginkgo leaves are vinegar ginkgo leaves.

[0009] Another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition.

[0010] A method for preparing a traditional Chinese medicine composition for delaying cardiovascular aging comprises the following steps: S1. Take coarse powder of Chuanxiong rhizome, add warm water and extract twice, combine the two medicinal solutions for standby use, and prepare the first decoction; S2. Chop the ginkgo leaves and add white vinegar, with the weight ratio of ginkgo leaves to white vinegar being 1:3. Then, ultrasonicate and filter. Grind the resulting residue through an 80-100 mesh sieve for later use. S3, taking the chuanxiong residue left in step S1, the vinegar ginkgo leaves prepared in step S2, and astragalus, codonopsis, jujube seeds, kudzu root, atractylodes, tangerine peel, cassia twig, and zedoaria officinalis, decocting with water, filtering, and cooling to prepare a second decoction; S4. Add the first decoction prepared in step S1 to the second decoction, mix them evenly in a blender, and filter them again to obtain a water decoction of the traditional Chinese medicine composition for delaying cardiovascular aging.

[0011] Preferably, in step S1, the warm soaking temperature is 60°C, 6 times the amount of water is added each time the extraction is performed, and each extraction is performed for 2 hours.

[0012] Preferably, in step S2, the ultrasonic temperature is 20-30° C., the ultrasonic time is 0.5-1.5 h, and the ultrasonic frequency is 30-40 kHz.

[0013] Preferably, in step S3, water is added and decocted three times in total, with 10, 5, and 5 times the weight of water added respectively, and decocted for 1 hour each time.

[0014] Pharmacological effects of the above raw materials: monarch drug Astragalus: slightly warm in nature, sweet in taste; enters the spleen and lung meridians, and treats spleen qi deficiency with poor appetite and loose stools, and long-term diarrhea and prolapse of the anus due to sinking of the middle qi. It can raise the clear yang qi, eliminate qi deficiency edema and dysuria, strengthen the spleen to help transport and transform water and dampness, moisten internal heat and quench thirst, and replenish qi and blood deficiency caused by sallow complexion and palpitations; the lungs control qi and help the heart circulate blood, and by replenishing the qi of the spleen and lungs, it promotes the transformation of qi and blood, and improves palpitations and fatigue caused by heart qi deficiency.

[0015] Codonopsis: sweet in taste, neutral in nature; it mainly enters the spleen and lung meridians, and also enters the heart meridian, replenishing the middle and benefiting qi, nourishing blood and producing body fluids, improving symptoms such as spleen and lung qi deficiency, poor appetite and fatigue, cough and shortness of breath, qi and blood deficiency, sallow complexion, palpitations and shortness of breath, thirst due to loss of body fluids, internal heat and thirst.

[0016] Ziziphus jujuba seeds: They are mild in nature, sweet and sour in taste; they enter the liver, gallbladder and heart meridians, and are mainly used to nourish blood and liver, calm the mind and tranquilize the nerves, astringe sweat and produce body fluid, relieve numbness and relieve pain. "Shennong's Herbal Classic" records that they can treat "cold and heat in the heart and abdomen, accumulation of evil qi, soreness and pain in the limbs, and dampness." "Ming Yi Bie Lu" says that it "treats restlessness and insomnia, spontaneous sweating and thirst."

[0017] Minister medicine Chuanxiong: It is pungent and warm in nature, and enters the liver, gallbladder, and pericardium meridians. It is mainly used to treat chest pain, heart pain, and stabbing pain in the ribs caused by qi stagnation and blood stasis. It is a "qi medicine in the blood" and is good at unblocking blood stasis.

[0018] Pueraria root: cool in nature, sweet and spicy in taste; enters the spleen, stomach, and lung meridians, relieves muscles and reduces fever, promotes fluid production and quenches thirst, clears rashes and detoxifies, raises yang and stops diarrhea, and promotes blood circulation and activates the meridians.

[0019] adjuvant Atractylodes macrocephala: warm in nature, bitter and sweet in taste; enters the spleen and stomach meridians, strengthens the spleen and replenishes Qi, dries dampness and promotes diuresis, consolidates the exterior and stops sweating, treats spleen deficiency, loss of appetite, abdominal distension and diarrhea, strengthens the transportation and transformation of the middle burner, treats edema, phlegm and fluid retention, and dysuria, and regulates water metabolism by strengthening the spleen and removing dampness; "Compendium of Materia Medica" calls it "the essential medicine for nourishing the spleen and stomach", saying that "when the earth is prosperous, the clear Qi rises and the essence and fine particles are delivered upward."

[0020] Tangerine peel: warm in nature, pungent and bitter in taste; it enters the spleen and lung meridians, can regulate qi and strengthen the spleen, relieve depression and relieve fullness. "Shennong's Herbal Classic" records that it "treats chest heat and reverse qi, and promotes water and food intake." It also contains flavonoids, which are antioxidants and can delay cell aging.

[0021] Cinnamon twig: warm in nature, spicy and sweet in taste; it enters the heart, lung and bladder meridians, and has the effects of inducing sweating and relieving muscles, warming and unblocking the meridians, assisting yang and transforming qi, and balancing and relieving adverse reactions. "Compendium of Materia Medica" states that it "treats all wind-cold phlegm and fluid, opens the pores, and dredges the blood vessels."

[0022] Ze Lan: slightly warm in nature, bitter and pungent in taste; it enters the liver and spleen meridians, can promote blood circulation and regulate menstruation, remove blood stasis and eliminate carbuncles, promote diuresis and reduce swelling. The modern "Chinese Pharmacopoeia" clearly defines its function of "promoting blood circulation, removing blood stasis, promoting diuresis and reducing swelling".

[0023] Ginkgo biloba: It is mild in nature, sweet, bitter and astringent in taste; it enters the heart and lung meridians, and has the effects of promoting blood circulation and removing blood stasis, unblocking meridians and relieving pain, strengthening the lungs and relieving asthma, and clearing turbidity and lowering blood lipids.

[0024] Enhancing drug Ziziphus jujuba seeds: They are mild in nature, sweet and sour in taste; they enter the liver, gallbladder and heart meridians, and are mainly used to nourish blood and liver, calm the mind and tranquilize the nerves, astringe sweat and produce body fluid, relieve numbness and relieve pain. "Shennong's Herbal Classic" records that they can treat "cold and heat in the heart and abdomen, accumulation of evil qi, soreness and pain in the limbs, and dampness." "Ming Yi Bie Lu" says that it "treats restlessness and insomnia, spontaneous sweating and thirst."

[0025] Beneficial effects of the present invention: The traditional Chinese medicine composition provided by the present invention is safe and effective, has a simple and convenient preparation process, has little toxic and side effect, and the original medicinal materials are economically easy to obtain and have low cost. In the formula of the present invention, astragalus, codonopsis, and spinach seed are used as monarch drugs, ligusticum chuanxiong and kudzu root are used as ministerial drugs, atractylodes, tangerine peel, cassia twig, zedoaria, and ginkgo leaf are used as adjuvant drugs, and spinach seed is used as a guiding drug. One drug has two uses. The present invention prepares the prescription according to the monarch-minister-assistant-guiding principle, and the combined use of the drugs can delay cardiovascular aging while improving the patient's sleep quality and improving the quality of life. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a picture of cell senescence of vascular endothelial cells in the normal control group under a 200x optical microscope; Figure 2 This is a picture of cell senescence of vascular endothelial cells in the model group under a 200x optical microscope; Figure 3This is a cell senescence image of the vascular endothelial cells in Example 1 under a 200x optical microscope; Figure 4 This is a cell senescence image of vascular endothelial cells in Example 2 under a 200x optical microscope; Figure 5 This is a picture of cell senescence of vascular endothelial cells in Example 3 under a 200x optical microscope. DETAILED DESCRIPTION

[0027] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0028] Example 1 The traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment is composed of the following traditional Chinese medicine raw materials in parts by weight: 14 parts of astragalus, 13 parts of codonopsis, 10 parts of jujube seeds, 8 parts of ligusticum, 15 parts of kudzu root, 10 parts of atractylodes, 5 parts of tangerine peel, 9 parts of cinnamon twig, 3 parts of zedoaria, and 6 parts of ginkgo leaves.

[0029] The preparation method of the traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment comprises the following steps: S1. Grind Chuanxiong into coarse powder, pass through an 80-100 mesh sieve, add 6 times the amount of 60°C warm water and soak and extract twice, each time for 2 hours, combine the two medicinal solutions and use them for later use to prepare the first decoction; S2. Chop the ginkgo leaves, add white vinegar, and the weight ratio of ginkgo leaves to white vinegar is 1:3. Then, ultrasonicate the mixture. Set the ultrasonic frequency to 35kHz and the ultrasonic temperature to 30°C for 1 hour. Then filter the mixture and grind the resulting residue through an 80-100 mesh sieve for later use. S3, take the remaining Chuanxiong residue from step S1, the vinegar ginkgo leaf and astragalus, Codonopsis, Ziziphus jujuba seed, Pueraria, Atractylodes macrocephala, dried tangerine peel, cinnamon twig, and Herba Lycopodii obtained in step S2, add water and decoct. The decoction is completed in three times. The amount of water added in the first decoction is 10 times the weight of the Chinese medicine raw material, and the decoction time is 1 hour. The amount of water added in the second and third decoctions is 5 times the weight of the raw material, and the decoction is carried out for 1 hour. The decoction is filtered and cooled to obtain the second decoction. S4. Add the first decoction prepared in step S1 to the second decoction, mix them evenly in a blender, and filter them again to obtain a water decoction of the traditional Chinese medicine composition for delaying cardiovascular aging.

[0030] Example 2 The traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment is composed of the following traditional Chinese medicine raw materials in parts by weight: 15 parts of astragalus, 15 parts of codonopsis, 13 parts of jujube seeds, 10 parts of chuanxiong, 12 parts of kudzu root, 7 parts of atractylodes, 6 parts of tangerine peel, 7 parts of cinnamon twig, 5 parts of zedoaria, and 3 parts of ginkgo leaves.

[0031] The preparation method of the traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment comprises the following steps: S1. Grind Chuanxiong into coarse powder, pass through an 80-100 mesh sieve, add 6 times the amount of 60°C warm water and soak and extract twice, each time for 2 hours, combine the two medicinal solutions and use them for later use to prepare the first decoction; S2. Cut the ginkgo leaves into small pieces, add white vinegar, and use a weight ratio of ginkgo leaves to white vinegar of 1:3. Then, perform ultrasonic treatment. Set the ultrasonic frequency to 40 kHz and the ultrasonic temperature to 20°C for 0.5 h. Then, filter and crush the resulting residue through an 80-100 mesh sieve for later use. S3, take the remaining Chuanxiong residue from step S1, the vinegar ginkgo leaf and astragalus, Codonopsis, Ziziphus jujuba seed, Pueraria, Atractylodes macrocephala, dried tangerine peel, cinnamon twig, and Herba Lycopodii obtained in step S2, add water and decoct. The decoction is completed in three times. The amount of water added in the first decoction is 10 times the weight of the Chinese medicine raw material, and the decoction time is 1 hour. The amount of water added in the second and third decoctions is 5 times the weight of the raw material, and the decoction is carried out for 1 hour. The decoction is filtered and cooled to obtain the second decoction. S4. Add the first decoction prepared in step S1 to the second decoction, mix them evenly in a blender, and filter them again to obtain a water decoction of the traditional Chinese medicine composition for delaying cardiovascular aging.

[0032] Example 3 The traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment is composed of the following traditional Chinese medicine raw materials in parts by weight: 12 parts of astragalus, 12 parts of codonopsis, 12 parts of jujube seeds, 15 parts of ligusticum, 10 parts of kudzu root, 6 parts of atractylodes, 10 parts of tangerine peel, 5 parts of cinnamon twig, 8 parts of zedoaria, and 2 parts of ginkgo leaves.

[0033] The preparation method of the traditional Chinese medicine composition for delaying cardiovascular aging provided in this embodiment comprises the following steps: S1. Grind Chuanxiong into coarse powder, pass through an 80-100 mesh sieve, add 6 times the amount of 60°C warm water and soak and extract twice, each time for 2 hours, combine the two medicinal solutions and use them for later use to prepare the first decoction; S2. Cut the ginkgo leaves into small pieces, add white vinegar, and use a weight ratio of ginkgo leaves to white vinegar of 1:3. Then, perform ultrasonic treatment. Set the ultrasonic frequency to 30 kHz and the ultrasonic temperature to 25°C for 1.5 hours. Then, filter and crush the filter residue through an 80-100 mesh sieve for later use. S3, take the remaining Chuanxiong residue from step S1, the vinegar ginkgo leaf and astragalus, Codonopsis, Ziziphus jujuba seed, Pueraria, Atractylodes macrocephala, dried tangerine peel, cinnamon twig, and Herba Lycopodii obtained in step S2, add water and decoct. The decoction is completed in three times. The amount of water added in the first decoction is 10 times the weight of the Chinese medicine raw material, and the decoction time is 1 hour. The amount of water added in the second and third decoctions is 5 times the weight of the raw material, and the decoction is carried out for 1 hour. The decoction is filtered and cooled to obtain the second decoction. S4. Add the first decoction prepared in step S1 to the second decoction, mix them evenly in a blender, and filter them again to obtain a water decoction of the traditional Chinese medicine composition for delaying cardiovascular aging.

[0034] Experimental Example 1 Cell senescence experiment Cell culture and grouping: Human umbilical cord endothelial cells (HUVECs) were purchased from the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. HUVECs were cultured in an incubator at 37°C with 5% CO2 using endothelial cell medium (ECM) containing 10% fetal bovine serum (FBS), 100 U / ml penicillin, 100 U / ml streptomycin, and 5 ng / ml VEGF.

[0035] Cell seeding and senescence-associated β-gal activity assay: Senescence-associated β-galactosidase (SA-β-gal) positive detection is a commonly used method to determine cell aging. Its principle is based on the significant increase in β-gal activity in aging cells, which catalyzes the substrate to produce a blue substance in an acidic environment.

[0036] The concentration of cultured HUVECs was adjusted to 1×10 5 Cells were inoculated into 24-well plates at a concentration of 1 ml per well and cultured. After the cells reached 80% or more fusion, the cells were divided into 5 groups with 3 replicates per group. The normal control group received no other treatment. The model group received AngII (10 -6 M) for 24 hours, Example 1 group: treated with the Chinese medicine composition prepared in Example 1 (1 mg / ml) for 0.5 hours, and then treated with AngII (10 -6 M) for 24 hours; Example 2 group: treated with the Chinese medicine composition prepared in Example 2 (1 mg / ml) for 0.5 hours, and then treated with AngII (10 -6 M) for 24 hours; Example 3 group: treated with the Chinese medicine composition prepared in Example 3 (1 mg / ml) for 0.5 hours, and then treated with AngII (10 -6 M) for 24 hours. Group processing endsAfterwards, the cells were washed three times with PBS and incubated overnight at 37°C with X-Gal solution (5-bromo-4-chloro-3-indolyl-X-gal). The culture plates were sealed with plastic wrap to prevent evaporation. The staining solution was discarded and the cells were washed three times with PBS. Senescent cells were observed under a 200x optical microscope and the number and proportion of senescent cells were calculated. The data are shown in Tables 1 and 2. Figures 1 to 5 shown.

[0037] Table 1 *Compared with normal control group; # Compared with the model group The results are shown in Table 1 and Figures 1 to 5 As shown, Figure 1 For the normal control group, Figure 2 For the model group, Figures 3 to 5 The cells in Examples 1-3 were stained sparingly in the normal control group, while a large number of blue-stained cells were observed in the model group. The number of blue-stained cells in the cells in Examples 1-3 decreased to varying degrees. This suggests that different drug ratios can improve the senescent state of vascular endothelial cells. The improvement in Example 1 was particularly significant.

[0038] Experimental Example 2 Antioxidant Activity SOD and MDA Detection The concentration of cultured HUVECs was adjusted to 1×10 5 Cells were plated in 24-well plates at a concentration of 1 ml per well. After the cells reached 80% fusion, the cells were divided into 5 groups with 3 replicates per group. Normal control group: no other treatment was performed. Model group: AngII (10 -6 M) for 24 hours, Example 1 group: treated with the Chinese medicine composition prepared in Example 1 (1 mg / ml) for 0.5 hours, and then treated with AngII (10 -6 M) for 24 hours; Example 2 group: treated with the Chinese medicine composition prepared in Example 2 (1 mg / ml) for 0.5 hours, and then treated with AngII (10 -6 M) for 24 hours; Example 3 group: first treated with the Chinese medicine composition prepared in Example 3 (1 mg / ml) for 0.5 hours, then treated with AngII (10 -6 After each treatment, the cell supernatant was collected and the SOD and MDA contents in the supernatant were detected. The results are shown in Table 2 below.

[0039] Table 2 *Compared with normal control group; # Compared with the model group The SOD activity of cells in the normal control group was higher, while that in the model group was lower. The SOD activity of cells in groups 1, 2, and 3 increased to varying degrees. This suggests that different ratios of the drug can improve the SOD activity of vascular endothelial cells. The improvement in group 1 was more significant.

[0040] The MDA content of cells in the normal control group was low, while that in the model group was high. The MDA content of cells in groups 1, 2, and 3 all decreased. This suggests that different ratios of the drug can reduce the MDA content of vascular endothelial cells, and the improvement in group 1 was more obvious.

[0041] Experimental Example 3 Continuous Sleep Time A continuous sleep test was performed on the Chinese medicinal compositions for delaying cardiovascular aging provided in Examples 1-3.

[0042] Test method: Fifty 8-week-old SPF Kunming mice, half male and half female, were randomly divided into 5 groups: a normal control group, a positive drug control group, and groups 1 to 3 of Examples, with 10 mice in each group. The normal control group was gavaged with the same volume of distilled water, the positive drug control group was gavaged with eszopiclone, and groups 1 to 3 of Examples were gavaged with the Chinese medicine composition provided in Examples 1 to 3 at a dosage of 4 g / kg for 7 consecutive days. One hour after the last dose, 50 mg / kg of sodium pentobarbital was intraperitoneally injected. The mice were then placed on a 30°C preheated platform to prevent hypothermia awakening. The mice were observed for the loss of righting reflex and recovery time, and the average sleep duration of each group was recorded and calculated. The test results are shown in Table 3.

[0043] Table 3 Group Average continuous sleep time (min) Normal control group 61.50±10.98 Positive drug control group 87.00±9.96* Example 1 group <![CDATA[101.00±5.97 *# ]]> Example 2 group <![CDATA[95.50±5.37 *# ]]> Example 3 group <![CDATA[98.50±6.06 *# ]]> *Compared with normal control group; #Compared with positive drug control group As can be seen from Table 3, when the drug was administered on the basis of the injection of sodium pentobarbital, the sleep time of the pentobarbital group + drug group was longer than that of the pentobarbital group alone, indicating that the drug had a better effect on improving sleep. The whole prescription was perfect and played a synergistic role, which promoted the sleep of mice and prolonged their sleep time.

[0044] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for delaying cardiovascular aging, characterized in that: The invention is composed of the following Chinese medicinal raw materials in parts by weight: 12-15 parts of astragalus, 12-15 parts of codonopsis, 10-13 parts of jujube seeds, 8-15 parts of chuanxiong, 10-15 parts of kudzu root, 6-10 parts of atractylodes, 5-10 parts of tangerine peel, 5-9 parts of cinnamon twig, 3-8 parts of zedoaria, and 2-6 parts of ginkgo leaves.

2. The Chinese medicine composition for delaying cardiovascular aging according to claim 1, characterized in that The medicine is composed of the following Chinese medicinal raw materials in parts by weight: 14 parts of astragalus, 13 parts of codonopsis, 10 parts of spinach seeds, 8 parts of ligusticum, 15 parts of kudzu root, 10 parts of atractylodes, 5 parts of tangerine peel, 9 parts of cinnamon twig, 3 parts of zedoaria, and 6 parts of ginkgo leaves.

3. The Chinese medicine composition for delaying cardiovascular aging according to claim 1 or 2, characterized in that: The ginkgo leaves are vinegar ginkgo leaves.

4. A method for preparing the traditional Chinese medicine composition for delaying cardiovascular aging according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Take coarse powder of Chuanxiong rhizome, add warm water and extract twice, combine the two medicinal solutions for standby use, and prepare the first decoction; S2. Chop the ginkgo leaves and add white vinegar. The weight ratio of ginkgo leaves to white vinegar is 1:

3. Then, ultrasonicate and filter. Grind the resulting residue through an 80-100 mesh sieve for later use. S3, taking the chuanxiong residue left in step S1, the vinegar ginkgo leaves prepared in step S2, and astragalus, codonopsis, jujube seeds, kudzu root, atractylodes, tangerine peel, cassia twig, and zedoaria officinalis, decocting with water, filtering, and cooling to prepare a second decoction; S4. Add the first decoction prepared in step S1 to the second decoction, mix them evenly in a blender, and filter them again to obtain a water decoction of the traditional Chinese medicine composition for delaying cardiovascular aging.

5. The method for preparing the Chinese medicine composition for delaying cardiovascular aging according to claim 4, characterized in that: In step S1, the warm soaking temperature is 60° C., 6 times the amount of water is added each time the extraction is performed, and each extraction takes 2 hours.

6. The method for preparing the Chinese medicine composition for delaying cardiovascular aging according to claim 4, characterized in that: In step S2, the ultrasonic temperature is 20-30° C., the ultrasonic time is 0.5-1.5 h, and the ultrasonic frequency is 30-40 kHz.

7. The method for preparing the Chinese medicine composition for delaying cardiovascular aging according to claim 4, characterized in that: In step S3, water is added and decocted for three times in total, with 10, 5, and 5 times the weight of water added respectively, and decocted for 1 hour each time.

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