Antibacterial dressing

Abstract

The invention relates to the technical field of biomedical materials, in particular to an antibacterial dressing which comprises a dressing base layer and a colloidal sulfur film layer stacked on the dressing base layer. The colloidal sulfur film layer is prepared according to the following method: S1: mixing sulfur with glycerol to obtain a mixture I; s2, mixing a macromolecular substance with water to obtain a mixture II; and S3, mixing the mixture I and the mixture II, and carrying out gradient drying to obtain the colloidal sulfur film layer. According to the antibacterial dressing provided by the invention, the colloidal sulfur film layer is introduced, so that the antibacterial dressing not only has excellent broad-spectrum antibacterial activity and good antibacterial durability, but also is beneficial to promoting wound healing and accelerating hemostasis, therefore, the antibacterial dressing is not only suitable for treating superficial wounds, I-degree burns and scalds, but also suitable for treating the superficial wounds, I-degree burns and scalds and shallow II-degree burns and scalds. The ointment can also be used for treating small acute hemorrhagic wounds, and has the effects of protecting wounds, providing a suitable environment for promoting wound healing, inhibiting microorganism growth of the wounds and reducing irritation.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical materials, in particular to an antibacterial dressing. Background Art

[0002] With the development and improvement of medical technology, there are more and more types of dressings related to wound care. Polyurethane dressing is a medical wound care material based on polyurethane film or foam. It has the characteristics of breathability, waterproofness, and low allergenicity. It is suitable for superficial wounds, postoperative incisions, chronic ulcers with less exudate, etc. It can maintain a moist environment and promote healing, while reducing the frequency of dressing changes and reducing irritation to the skin. Compared with traditional dressings, polyurethane dressings are more comfortable and convenient to use, and can reduce the pain of dressing changes for patients. However, for some infected wounds, the use of ordinary polyurethane dressings will lead to slower wound healing due to insufficient antibacterial properties. Therefore, it is necessary to inhibit the growth of microorganisms while caring for the wound. Summary of the Invention

[0003] In order to solve the problem of insufficient antibacterial performance of polyurethane dressings in the prior art, the present invention provides an antibacterial dressing, which imparts antibacterial performance by introducing a colloidal sulfur film layer, thereby solving the problem of insufficient antibacterial performance of polyurethane dressings in the prior art.

[0004] The technical solution adopted by the present invention to solve its technical problem is: An antibacterial dressing comprises a dressing base layer and a colloidal sulfur film layer stacked on the dressing base layer; The colloidal sulfur film layer is prepared according to the following method: S1: mixing sulfur and glycerol to obtain mixture I; S2: mixing the polymer substance with water to obtain mixture II; S3: Mixing the mixture I and the mixture II, and performing gradient drying to obtain a colloidal sulfur film layer.

[0005] Optionally, the gradient drying process includes a first drying stage, a second drying stage and a third drying stage; wherein the temperature in the first drying stage is increased from 30°C to 35°C, the vacuum degree is -0.03~-0.05MPa, and the drying time is 2-3h; the temperature in the second drying stage is increased from 35°C to 45°C, the vacuum degree is -0.07~-0.08MPa, and the drying time is 2-3h; the temperature in the third drying stage is increased from 45°C to 50°C, the vacuum degree is -0.09~-0.095MPa, and the drying time is 2-3h.

[0006] Optionally, based on weight fractions, the added amount of the sulfur is 5-50 parts; the added amount of the glycerol is 1-20 parts; and the added amount of the polymer substance is 0.1-5 parts.

[0007] Optionally, the polymer substance is selected from at least one of sodium carboxymethyl cellulose, xanthan gum, sodium alginate, and gelatin.

[0008] Optionally, the dressing base layer includes a first polyurethane film layer.

[0009] Optionally, the dressing base layer further includes a first polyurethane foam layer disposed between the first polyurethane film layer and the colloidal sulfur film layer.

[0010] Optionally, the antibacterial dressing further comprises a dressing cover layer stacked with the colloidal sulfur film layer; the colloidal sulfur film layer is located between the dressing base layer and the dressing cover layer.

[0011] Optionally, the dressing covering layer includes a second polyurethane foam layer; the second polyurethane foam layer is provided with an open-cell structure.

[0012] Optionally, the dressing covering layer includes a second polyurethane film layer; the second polyurethane film layer is provided with an open-pore structure.

[0013] Optionally, the dressing covering layer includes a silicone gel layer; an open-pore structure is provided on the silicone gel layer.

[0014] The beneficial effects of the present invention are: The antibacterial dressing provided by the present invention, by introducing a colloidal sulfur film layer, not only has excellent broad-spectrum antibacterial activity and good antibacterial durability, but also helps promote wound healing and accelerate hemostasis. Therefore, the antibacterial dressing is not only suitable for the treatment of superficial trauma, first-degree and shallow second-degree burns and scalds, but can also be used to treat small acute bleeding wounds. It has the effects of protecting wounds, providing a suitable environment for promoting wound healing, inhibiting the growth of wound microorganisms, and reducing irritation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The present invention will be further described below with reference to the accompanying drawings and examples.

[0016] Figure 1 It is a simplified structural diagram of the antibacterial dressing of the present invention.

[0017] In the figure: 1 - dressing base layer; 11 - first polyurethane film layer; 12 - first polyurethane foam layer; 2 - colloidal sulfur film layer; 3 - dressing cover layer. DETAILED DESCRIPTION

[0018] The present invention will now be described in further detail. The embodiments described below are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention. All other embodiments obtained by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are intended to fall within the scope of protection of the present invention.

[0019] In the description of the present invention, it should be understood that the terms "first" and "second" are used only to simplify the description and should not be understood to indicate or imply relative importance, or implicitly specify the number of the technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise specifically defined.

[0020] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" the first feature may include the first feature being in direct contact with the second feature, or may include the first feature being in contact with the second feature through another feature between them instead of being in direct contact. Moreover, a first feature being "above," "above," and "above" the second feature includes the first feature being directly above or obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" the second feature includes the first feature being directly below or obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0021] In order to solve the problem of insufficient antibacterial performance of polyurethane dressings in the prior art, the present invention provides an antibacterial dressing, see Figure 1 As shown, the antimicrobial dressing includes a dressing base 1 and a colloidal sulfur film layer 2 stacked on the dressing base 1. The dressing base 1 can be made of an existing polyurethane dressing, such as a polyurethane film or polyurethane foam. To improve the antimicrobial properties of the dressing, the colloidal sulfur film layer 2 is introduced into the dressing as an antimicrobial layer. During use, the colloidal sulfur film layer 2 is in contact with the wound.

[0022] Traditional polyurethane antibacterial dressings usually obtain their antibacterial properties by introducing silver ions or antibiotics as antibacterial agents; among these antibacterial agents, silver ions have broad-spectrum antibacterial properties, but high concentrations of silver ions are toxic to fibroblasts and, when used on wounds, will delay wound healing; antibiotics have a narrow antibacterial spectrum and it is difficult to fully cover pathogens in the wound.

[0023] Colloidal sulfur, also known as delta-sulfur, is a type of sulfur that is so fine that it can be suspended in water. Its main component is sulfur, which kills many bacteria and fungi and exhibits excellent broad-spectrum antimicrobial activity. This broad spectrum is highly beneficial for treating complex wounds or infections with unidentified pathogens. Colloidal sulfur primarily releases sulfur molecules / sulfide ions, interfering with microbial enzyme systems and protein structures (particularly disrupting disulfide bonds), inhibiting respiration and metabolism, and ultimately leading to microbial death. Due to its nonspecific, multi-target mode of action, it is difficult for microorganisms to develop effective resistance to colloidal sulfur through a single mutation. This is particularly important in combating the growing prevalence of antibiotic-resistant and silver-resistant bacteria. Furthermore, sulfur is an essential trace element for the human body and is involved in numerous important physiological processes. Appropriate amounts of sulfur have anti-inflammatory effects, promote keratinization, and stimulate fibroblast proliferation and collagen synthesis. Therefore, using a colloidal sulfur film as an antimicrobial layer not only exhibits excellent antimicrobial properties but also helps promote wound healing and accelerate hemostasis.

[0024] The present application introduces a colloidal sulfur film layer into the dressing, so that the colloidal sulfur film layer can slowly and continuously release active sulfur components in the environment of wound exudate, providing long-term antibacterial protection and reducing the number of frequent dressing changes.

[0025] However, due to the high surface energy of sulfur ions, they are prone to agglomeration, sedimentation, crystallization, etc., which can easily lead to cracks, holes or uneven distribution during film formation; pure sulfur particles are mainly bound by van der Waals forces, lacking the chain entanglement or chemical cross-linking of polymer materials, and it is difficult to spontaneously form a flexible, continuous film; during the drying process of the colloid, the solvent evaporates, and stress is generated when the particles aggregate and shrink, which can easily lead to brittle cracking of the film; therefore, although colloidal sulfur has excellent antibacterial properties, due to its difficulty in forming a film, it is currently impossible to introduce colloidal sulfur into dressings for antibacterial purposes through a colloidal sulfur film layer, which limits its application in antibacterial dressings.

[0026] Based on this, in order to facilitate the introduction of colloidal sulfur into the dressing in the form of a film layer, the colloidal sulfur film layer 2 is preferably prepared according to the following method: S1: mixing sulfur and glycerol to obtain mixture I; By mixing sulfur with glycerin, the high viscosity and polarity of glycerin are utilized to improve the dispersibility and stability of sulfur, allowing sulfur particles to be evenly suspended and preventing them from settling and clumping. Furthermore, glycerin acts as a powerful hygroscopic agent. When the dressing comes into contact with the wound, glycerin absorbs moisture, softens the skin's stratum corneum, and promotes the penetration of sulfur into the hair follicles or deeper layers of the epidermis. The synergistic effect of glycerin and sulfur further enhances the antibacterial properties. S2: mixing the polymer substance with water to obtain mixture II; S3: Mixing mixture I and mixture II, and performing gradient drying to obtain a colloidal sulfur film layer.

[0027] By mixing mixture I and mixture II, the polymer substance fills the gaps between the sulfide ions, providing a flexible skeleton to enhance the continuity and mechanical strength of the membrane; further, through gradient drying, the surface and shallow moisture is slowly removed, and the internal moisture is promoted to gradually migrate to the surface layer, so that the internal moisture is evenly removed, and gradual drying from the surface layer to the inner layer is achieved, reducing the accumulation of internal stress. At the same time, the polymer substance is gradually cross-linked under the action of glycerol to form a flexible network, thereby obtaining a colloidal sulfur film layer suitable for dressings.

[0028] The antibacterial dressing provided by the present invention, by introducing the colloidal sulfur film layer 2, not only has excellent broad-spectrum antibacterial activity and good antibacterial durability, but also helps to promote wound healing and accelerate hemostasis. Therefore, the antibacterial dressing is not only suitable for the treatment of superficial trauma, first-degree and shallow second-degree burns and scalds, but can also be used for the treatment of acute minor bleeding wounds, and has the effects of protecting wounds, providing a suitable environment for promoting wound healing, inhibiting the growth of wound microorganisms, and reducing irritation.

[0029] The gradient drying process in the present invention can be repeated for 48-72 hours from room temperature to low temperature (4° C.) to room temperature to form a thin film and obtain the colloidal sulfur film layer 2 .

[0030] To further avoid film brittle cracking during the drying process, the present invention preferably adopts a gradient drying process comprising a first drying stage, a second drying stage, and a third drying stage; wherein the temperature in the first drying stage is increased from 30° C. to 35° C., the vacuum degree is -0.03 to -0.05 MPa, and the drying time is 2 to 3 hours; the temperature in the second drying stage is increased from 35° C. to 45° C., the vacuum degree is -0.07 to -0.08 MPa, and the drying time is 2 to 3 hours; and the temperature in the third drying stage is increased from 45° C. to 50° C., the vacuum degree is -0.09 to -0.095 MPa, and the drying time is 2 to 3 hours, to form a thin film and obtain a colloidal sulfur film layer 2.

[0031] Specifically, during the first drying stage, the vacuum degree is slowly increased to remove free water, so that the membrane is initially formed (forming a certain mechanical strength) and avoiding boiling. The boiling point of water at -0.03~-0.05MPa is about 70-85℃, which is close to the mild state of evaporation at room temperature. 30 to 35℃ is lower than the glass transition temperature of the colloid matrix, avoiding matrix denaturation. In the second drying stage, the process is to accelerate the removal of bound water (hydrogen bond between colloid and water). At this time, the membrane has formed a certain strength (when the water content is 40%, the colloid matrix begins to cross-link), which can be improved. To improve dehydration efficiency, the boiling point of water at -0.07~-0.08MPa is about 55-60℃, which is still lower than the denaturation temperature of most colloids. The temperature should be raised slowly from 35 to 45℃, 5℃ per hour, to avoid a sudden temperature rise that causes sulfur particles to agglomerate. In the third drying stage, the process is to remove residual microporous water and ensure the stability of the membrane (when the moisture content is <5%, sulfur particles are not easy to migrate). The boiling point of water at -0.09~-0.095MPa is about 40-45℃, which is low temperature and high efficiency. At 45 to 50℃, the membrane strength is sufficient, and the temperature can be appropriately raised to accelerate dehydration.

[0032] The present invention successfully prepares a colloidal sulfur film layer 2 suitable for a dressing by dispersing sulfur with glycerol, providing a flexible skeleton with a polymer, and combining it with a gradient drying method. The colloidal sulfur is introduced in a film-like form, further improving the antibacterial properties of the dressing and prolonging the durability of its antibacterial properties.

[0033] In order to take into account both antibacterial properties and film-forming properties, the present invention preferably adds 5-50 parts of sulfur, 1-20 parts of glycerol, 0.1-5 parts of polymer substances, and 100-500 parts of water, based on weight.

[0034] Furthermore, the present invention preferably uses at least one polymer selected from sodium carboxymethyl cellulose, xanthan gum, sodium alginate, and gelatin.

[0035] In the present invention, the thickness of the colloidal sulfur film layer 2 is preferably 500-1000 μm.

[0036] The dressing base layer 1 in the present invention can be made of existing polyurethane dressings; the dressing base layer 1 preferably includes a polyurethane film layer, which is referred to as the first polyurethane film layer 11. The first polyurethane film layer 11 can be a self-adhesive polyurethane film layer.

[0037] The dressing base layer in the present invention may further include a polyurethane foam layer, specifically, a polyurethane foam layer arranged between the first polyurethane film layer 11 and the colloidal sulfur film layer 2, denoted as the first polyurethane foam layer 12; when the polyurethane foam layer is introduced, the first polyurethane film layer is preferably a self-adhesive polyurethane film layer.

[0038] To further improve comfort during use, the antibacterial dressing of the present invention preferably further includes a dressing cover layer 3 stacked on the colloidal sulfur film layer 2; the colloidal sulfur film layer 2 is located between the dressing base layer 1 and the dressing cover layer 3; during use, the dressing cover layer 3 is in contact with the skin; to ensure antibacterial properties, the dressing cover layer 3 is provided with an open-pore structure so that the colloidal sulfur film layer 2 can come into contact with wound exudate during use, allowing the colloidal sulfur film layer 2 to release active sulfur components. The released active sulfur components can then migrate to the wound through the open-pore structure, thereby exerting an antibacterial and hemostatic effect.

[0039] Specifically, the dressing covering layer 3 includes a polyurethane foam layer, which is referred to as a second polyurethane foam layer; an open-pore structure is provided on the second polyurethane foam layer.

[0040] The dressing covering layer 3 may further include a polyurethane film layer, referred to as a second polyurethane film layer; an open-pore structure is provided on the second polyurethane film layer, and the second polyurethane film layer is a self-adhesive polyurethane film layer.

[0041] The dressing covering layer 3 further includes a silicone gel layer; an open-pore structure is provided on the silicone gel layer.

[0042] The polyurethane foam layer of the present invention can be prepared according to the following method: Material A and material B are mixed evenly in a mass ratio of (2-3):1 and then coated on release paper. After the reaction, they are dried in a microwave oven to obtain the obtained material. Material A is prepared by adding PEG3350 and PE6400 to purified water and mixing them evenly. The mass ratio of PEG3350, PE6400 and purified water is 5:3:20. Material B is prepared by mixing isocyanate and SAP in a mass ratio of 10:1.

[0043] The silicone gel layer of the present invention can be prepared by the following method: component A and component B are mixed evenly in a mass ratio of 10:1, coated on a release film, and cured; wherein component A is a polydimethylsiloxane base glue; component B is an organic tin curing agent.

[0044] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0045] Example 1 This embodiment provides an antibacterial dressing, comprising a first polyurethane film layer 11, a first polyurethane foam layer 12, a colloidal sulfur film layer 2, and a second polyurethane foam layer stacked in sequence from bottom to top. The second polyurethane foam layer is provided with an open-pore structure, the pore size of the open-pore structure is 500 μm, and the pores are evenly distributed. The open-pore ratio of the second polyurethane foam layer is 40%.

[0046] The first polyurethane film layer 11 was purchased from Shanghai Jiaji Technology Co., Ltd.

[0047] The first polyurethane foam layer 12 and the second polyurethane foam layer are prepared according to the following method: Material A and material B are mixed evenly in a mass ratio of 2:1 and then coated on release paper, and dried in a microwave oven after the reaction; material A is obtained by adding PEG3350 and PE6400 to purified water and mixing them evenly, and the mass ratio of PEG3350, PE6400 and purified water is 5:3:20; material B is obtained by mixing isocyanate and SAP in a mass ratio of 10:1.

[0048] The thickness of the first polyurethane foam layer 12 and the second polyurethane foam layer is 2 mm.

[0049] The colloidal sulfur film layer 2 is prepared as follows: S1: Based on parts by weight, 30 parts of sulfur powder and 10 parts of glycerol were stirred at 500 rpm for 15 minutes to obtain a mixture I; S2: 3 parts of sodium carboxymethyl cellulose powder and 300 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mix mixture I and mixture II, stir at 500 rpm for 30 min, and then dry them in a vacuum drying oven according to the following process: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film to obtain colloidal sulfur film layer 2.

[0050] The thickness of the colloidal sulfur film layer 2 is 0.8 mm.

[0051] Example 2 The difference between this embodiment and embodiment 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: Based on parts by weight, 50 parts of sulfur powder and 20 parts of glycerol were stirred at 500 rpm for 15 minutes to obtain a mixture I; S2: 5 parts of sodium carboxymethyl cellulose powder and 500 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mix mixture I and mixture II, stir at 500 rpm for 30 min, and then dry them in a vacuum drying oven according to the following process: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film to obtain colloidal sulfur film layer 2.

[0052] The thickness of the colloidal sulfur film layer 2 is 1 mm.

[0053] Example 3 The difference between this embodiment and embodiment 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: Based on parts by weight, 5 parts of sulfur powder and 1 part of glycerol were stirred at 300 rpm for 10 minutes to obtain a mixture I; S2: 0.1 parts of sodium carboxymethyl cellulose powder and 10 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mix mixture I and mixture II, stir at 500 rpm for 30 min, and then dry them in a vacuum drying oven according to the following process: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film to obtain colloidal sulfur film layer 2.

[0054] The thickness of the colloidal sulfur film layer 2 is 0.6 mm.

[0055] Example 4 The difference between this embodiment and embodiment 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: 30 parts by weight of sulfur powder and 10 parts by weight of glycerol were stirred at 500 rpm for 15 minutes to obtain a mixture I. S2: 3 parts of sodium carboxymethyl cellulose powder, 1 part of xanthan gum, 1 part of sodium alginate and 500 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mix mixture I and mixture II, stir at 500 rpm for 30 min, and then dry them in a vacuum drying oven according to the following process: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film to obtain colloidal sulfur film layer 2.

[0056] Example 5 The difference between this embodiment and embodiment 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: Based on parts by weight, 30 parts of sulfur powder and 10 parts of glycerol were stirred at 500 rpm for 15 minutes to obtain a mixture I; S2: 3 parts of sodium carboxymethylcellulose powder, 1 part of gelatin, and 400 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mix mixture I and mixture II, stir at 500 rpm for 30 min, and then dry them in a vacuum drying oven according to the following process: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film to obtain colloidal sulfur film layer 2.

[0057] Example 6 The difference between this embodiment and embodiment 1 is that the second polyurethane foam layer is replaced by a silicone gel layer; an open-pore structure is provided on the silicone gel layer, the pore size of the open-pore structure is 500 μm, and the pores are evenly distributed, and the open-pore ratio of the second polyurethane foam layer is 40%.

[0058] The silicone gel layer was prepared as follows: Component A and component B are mixed evenly in a mass ratio of 10:1 and then coated on release paper, and dried in a microwave oven after the reaction; wherein component A is polydimethylsiloxane base glue; component B is an organic tin curing agent.

[0059] The thickness of the silicone gel layer is 0.5 mm.

[0060] Each comparative example in the present invention is compared with Example 1.

[0061] Comparative Example 1 The difference between this comparative example and Example 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: 30 parts by weight of sulfur powder and 10 parts by weight of glycerol were stirred at 500 rpm for 15 minutes to obtain a mixture I. S2: 3 parts of sodium carboxymethyl cellulose powder and 300 parts of water were stirred at 600 rpm for 15 minutes to obtain mixture II; S3: Mixture I and mixture II were mixed, stirred at 500 rpm for 30 min, and then dried in an oven at 60° C. and 30% humidity for 18 h to form a thin film, thereby obtaining a colloidal sulfur film layer 2.

[0062] Comparative Example 2 The difference between this comparative example and Example 1 is that the colloidal sulfur film layer 2 is prepared according to the following method: S1: According to parts by weight, 30 parts of sulfur powder, 10 parts of glycerol, 3 parts of sodium carboxymethyl cellulose powder and 300 parts of water were stirred at 600 rpm for 15 minutes to obtain a mixture; S2: The mixture was dried in a vacuum drying oven in the following order: -0.04 MPa, 30°C to 35°C, 2.5 h; -0.07 MPa, 35°C to 45°C, 2.5 h; -0.09 MPa, 45°C to 50°C, 2.5 h to form a thin film, thereby obtaining colloidal sulfur film layer 2.

[0063] The antibacterial performance and antibacterial durability of the antibacterial dressings prepared in the above examples and comparative examples were tested using the following test methods: Antibacterial performance: Refer to Appendix C of GB 15979-2002 "Hygienic Standard for Disposable Sanitary Products" and test the antibacterial rate against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 6538), and Candida albicans (ATCC 10231). The antibacterial rate is required to be ≥90%; Antibacterial persistence: Soak the dressing in normal saline (37°C, 100 rpm) and take it out after 1 day, 3 days, and 7 days respectively. Test the antibacterial rate according to the above method. The antibacterial rate is required to be ≥90% after 7 days.

[0064] The test results are shown in Table 1 and Table 2: Table 1 Antibacterial performance (antibacterial rate %) Escherichia coli Staphylococcus aureus Candida albicans Example 1 98.5 99.2 95.6 Example 2 99.3 99.5 96.8 Example 3 92.1 93.5 92.2 Example 4 97.8 98.9 94.3 Example 5 97.5 98.6 93.9 Example 6 96.9 98.2 92.7 Comparative Example 1 82.3 83.6 78.5 Comparative Example 2 79.6 81.2 76.8 Table 2 Antibacterial persistence (antibacterial rate, 7 days later) Escherichia coli Staphylococcus aureus Candida albicans Example 1 95.3 96.1 93.5 Example 2 96.8 97.2 94.8 Example 3 90.5 91.2 90.1 Example 4 94.6 95.8 91.7 Example 5 94.2 95.3 91.2 Example 6 93.8 94.9 90.5 Comparative Example 1 75.6 76.3 72.1 Comparative Example 2 73.2 74.5 69.8 The difference between Comparative Example 1 and Example 1 is that the gradient drying method is not adopted. Due to the excessively fast drying speed, stress concentration occurs inside the film layer, cracks and holes appear on the surface, sulfur is unevenly distributed, and antibacterial performance and durability are reduced.

[0065] The difference between Comparative Example 2 and Example 1 is that the sulfur is not premixed with glycerol. Due to direct mixing, the sulfur agglomerates and is unevenly dispersed, resulting in insufficient local antibacterial components in the film layer and poor stability of the antibacterial effect.

[0066] With the above-described preferred embodiments of the present invention as a guide, and with reference to the above description, relevant personnel are fully capable of making various changes and modifications without departing from the technical scope of this invention. The technical scope of this invention is not limited to the contents of the specification and must be determined according to the scope of the claims.

Claims

1. An antibacterial dressing, characterized in that: It comprises a dressing base layer (1), and a colloidal sulfur film layer (2) stacked on the dressing base layer (1); The colloidal sulfur film layer (2) is prepared according to the following method: S1: mixing sulfur and glycerol to obtain mixture I; S2: mixing the polymer substance with water to obtain mixture II; S3: Mixing the mixture I and the mixture II, and performing gradient drying to obtain a colloidal sulfur film layer.

2. The antibacterial dressing according to claim 1, wherein The gradient drying process includes a first drying stage, a second drying stage and a third drying stage; wherein the temperature in the first drying stage is increased from 30°C to 35°C, the vacuum degree is -0.03~-0.05MPa, and the drying time is 2-3h; the temperature in the second drying stage is increased from 35°C to 45°C, the vacuum degree is -0.07~-0.08MPa, and the drying time is 2-3h; the temperature in the third drying stage is increased from 45°C to 50°C, the vacuum degree is -0.09~-0.095MPa, and the drying time is 2-3h.

3. The antibacterial dressing according to claim 1, wherein Calculated by weight, the added amount of the sulfur is 5-50 parts; the added amount of the glycerol is 1-20 parts; and the added amount of the high molecular weight substance is 0.1-5 parts.

4. The antibacterial dressing according to claim 1, wherein The polymer substance is selected from at least one of sodium carboxymethyl cellulose, xanthan gum, sodium alginate and gelatin.

5. The antibacterial dressing according to any one of claims 1 to 4, characterized in that: The dressing base layer (1) comprises a first polyurethane film layer (11).

6. The antibacterial dressing according to claim 5, characterized in that The dressing base layer further comprises a first polyurethane foam layer (12) arranged between the first polyurethane film layer (11) and the colloidal sulfur film layer (2).

7. The antibacterial dressing according to claim 6, characterized in that The antibacterial dressing further comprises a dressing covering layer (3) stacked on the colloidal sulfur film layer (2); the colloidal sulfur film layer (2) is located between the dressing base layer (1) and the dressing covering layer (3).

8. The antibacterial dressing according to claim 7, characterized in that The dressing covering layer (3) comprises a second polyurethane foam layer; an open-cell structure is provided on the second polyurethane foam layer.

9. The antibacterial dressing according to claim 7, characterized in that The dressing covering layer (3) comprises a second polyurethane film layer; an open-pore structure is provided on the second polyurethane film layer.

10. The antibacterial dressing according to claim 7, characterized in that The dressing covering layer (3) comprises a silicone gel layer; an open-pore structure is provided on the silicone gel layer.

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