Preparation method of linolenic acid structure ester with synergistic biological activity

By preparing linolenic acid structural esters, the functional limitations of single ingredients of linolenic acid, quercetin and EPA are solved, the synergistic biological activity of multiple targets is achieved, and its application effect in the food and pharmaceutical fields is enhanced.

CN120683194APending Publication Date: 2025-09-23HEZE ZHONGHEJIANYUAN BIOLOGY TECH CO LTD
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Patent Information

Application Number
CN202510820696.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-19
Publication Date
2025-09-23

AI Technical Summary

Technical Problem

In the existing technology, the functions of single ingredients such as linolenic acid, quercetin and EPA have limitations, such as easy oxidation, low bioavailability, and single function. In addition, the synergistic effect of multiple ingredients is insufficient, which limits their application in the food and pharmaceutical fields.

Method used

By preparing a linolenic acid structured ester with synergistic biological activity, using Rhizopus dei to screen lipase, combining SBA-15 molecular sieve and composite catalyst, the preparation method includes the steps of esterification, transesterification and molecular distillation to form a complex ester of linolenic acid, quercetin and EPA.

Benefits of technology

It achieves the synergistic effect of linolenic acid, quercetin and EPA, enhances biological activity, improves stability, has a wide range of health benefits, and is suitable for improving cardiovascular and cerebrovascular health and enhancing immunity.

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Abstract

The invention discloses a preparation method of linolenic acid structural ester with synergistic biological activity, and relates to the technical field of linolenic acid structural ester preparation.The preparation method comprises the steps that specific lipase is prepared through rhizopus wei, and after an SBA-15 molecular sieve is treated, the lipase is fixed to prepare a composite catalyst; the preparation method comprises the following steps: after hydroxyl protection of quercetin, esterifying quercetin with EPA to obtain quercetin-EPA ester; esterifying glycerol and linolenic acid in the presence of a composite catalyst and microwaves, and purifying to obtain an intermediate product; carrying out microwave catalytic ester exchange on the intermediate product and quercetin-EPA ester in tert-butyl alcohol through a composite catalyst to obtain a crude product; and removing impurities from the crude product by a urea adduction method, and carrying out molecular distillation graded purification, column chromatography, deodorization and filtration to obtain a final product. According to the invention, linolenic acid, quercetin and EPA are combined through molecular design to form a compound structure ester with a multi-target effect, and the linolenic acid, quercetin and EPA achieve functional complementation through a synergistic effect, so that the biological activity of the compound structure ester is enhanced.
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