A redness-reducing treatment composition, and methods of making and using the same

Abstract

The application belongs to the technical field of cosmetics, and discloses a red fading repair composition, a preparation method thereof and application. The preparation method of the red fading repair composition comprises the following steps: (1) crushing oat kernels, sieving and extracting with pure water to obtain oat kernel extract; (2) adding fresh green beans to a glycerol / water mixed solution containing hydroxyacetic acid, crushing and dispersing with a high-speed homogenizer to obtain a homogenate without particles, and stirring and extracting under low-temperature conditions of 4-10 DEG C to obtain green bean seed extract; and (3) uniformly mixing glycerophosphoinositol choline salt, oat kernel extract and green bean seed extract according to a mass ratio of 0.1-2:10-40:50-80 to obtain the red fading repair composition. The red fading repair composition of the application uses green bean seed extract prepared by a specific process as a main raw material, and can achieve a significantly improved red fading repair effect through the synergistic effect of oat kernel extract and GPI.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a redness-removing repair composition as well as a preparation method and application thereof. BACKGROUND

[0002] With the improvement of modern living standards, the application and promotion of minimally invasive and non-invasive medical and beauty technologies, and the overuse of quick-acting cosmetics, the stratum corneum of the skin is often damaged to a certain extent. This leads to a weakened skin barrier function, which is easily stimulated by environmental factors (such as wind, cold air, sunlight) and cosmetic ingredients, resulting in skin problems such as redness, itching, and burning sensation. A care solution that can be applied in the above multiple scenarios is urgently needed.

[0003] The patent document with the publication number CN112603867A discloses a film repair essence, which uses glycerophosphoinositol choline salt, tetrahydro pyrimidine, and radix stephaniae tetrandrae extract to cooperate with each other, thereby achieving excellent anti-allergy, anti-inflammatory, and anti-itching effects, regenerating damaged skin, and having good skin barrier repair function, and also regulating skin oil secretion to achieve oil control effect. The patent document with the publication number CN119454555A discloses a composition with after-sun repair and whitening effects, which uses glycerophosphoinositol choline salt and citrus peel extract compound, and skin lightening agent compound to improve the after-sun repair and whitening effects of the composition.

[0004] The patent document with the publication number CN112842985A discloses a moisturizing repair composition, which uses dextran and AVENA SATIVA kernel extract to compound, thereby soothing and caring, helping skin self-repair, and maintaining skin moisture. The patent document with the publication number CN119112748A discloses a soothing repair composition, which includes 45% to 55% raspberry fruit extract solution, 40% to 50% needle leaf cherry extract solution, and 5% to 15% oat kernel extract powder, and the combination of the three can improve the soothing repair effect of raspberry fruit.

[0005] The patent document with the publication number CN107961199A discloses a skin repair cream for acne and inflammation, which uses traditional Chinese medicine ingredients including mung beans and natural plant active ingredients to cooperate with each other, thereby having no side effects on the skin and good acne and inflammation-removing effects.

[0006] Currently available technologies mainly focus on synergistic effects of glycerophosphate inositol choline salt, oat kernel extract, and mung bean extract with different functional components to achieve corresponding soothing, repairing, acne-reducing, and anti-inflammatory effects. However, no research has been conducted on the synergistic effects among glycerophosphate inositol choline salt, oat kernel extract, and mung bean seed extract, or on the influence of the preparation process conditions of mung bean seed extract on the efficacy of the composition. Summary of the Invention

[0007] In view of the shortcomings and deficiencies of the existing technology, the primary objective of this invention is to provide a method for preparing a redness-reducing and repairing composition.

[0008] Another object of the present invention is to provide a redness-reducing and repairing composition prepared by the above method.

[0009] Another object of the present invention is to provide the application of the above-mentioned redness-reducing and repairing composition in cosmetics.

[0010] The objective of this invention is achieved through the following technical solution:

[0011] A method for preparing a redness-reducing and repairing composition includes the following preparation steps:

[0012] (1) Preparation of oat kernel extract: Oat kernels (unripe) were crushed, sieved and extracted with pure water to obtain oat kernel extract;

[0013] (2) Preparation of mung bean seed extract: Fresh mung beans were added to a glycerol / water mixed solution containing glycolic acid, and the mixture was crushed, dispersed and homogenized with a high-speed homogenizer until no particles were present. The mixture was then stirred and extracted at a low temperature of 4-10℃ to obtain mung bean seed extract.

[0014] (3) Glycerol phosphate inositol choline (GPI) was mixed with oat kernel extract and mung bean seed extract in a mass ratio of 0.1-2:10-40:50-80 to obtain a redness-reducing and repairing composition.

[0015] Furthermore, the crushing and sieving mentioned in step (1) refers to passing the material through a 60-mesh sieve.

[0016] Furthermore, in step (1), the mass ratio of the material to the liquid in the pure water extraction is 1:20-40, the extraction temperature is 85-95℃, and the extraction time is 1-3h.

[0017] Further, the mixture extracted with pure water in step (1) is naturally cooled and then refrigerated at 0-4℃ for 12-36 hours. The supernatant is then collected by centrifugation at 5000-10000rpm for 10-30 minutes to obtain oat kernel extract.

[0018] Oat kernels mainly contain β-glucan, flavonoids, phenolic acids and their derivatives, vitamin E, phytic acid compounds, and unsaturated oils. They have moisturizing, skin-repairing, barrier-repairing, anti-wrinkle, antioxidant, whitening, and spot-removing effects. This invention utilizes oat kernel extract to further synergistically enhance the redness-reducing and repairing effects of mung bean seed extract.

[0019] Further, in step (2), the glycerol / water mixed solution containing glycolic acid has a glycerol content of 20-40% by mass, and the glycolic acid content makes the pH of the mixed solution 4.5-6. The extraction process of the mung bean seed extract of the present invention has a significant impact on the redness-reducing and repairing efficacy of the obtained composition. By using a mixed solvent of glycerol and water for extraction, the affinity and compatibility of glycerol with chlorogenic acid and other polyhydroxy active ingredients can be utilized to obtain an extract rich in chlorogenic acid. Furthermore, by extracting under acidic conditions of glycolic acid and at a low temperature of 4-10℃, the activity of chlorogenic acid and other components is effectively guaranteed, thereby significantly improving the redness-reducing and repairing efficacy of the composition.

[0020] Further, in step (2), the fresh mung beans are added to a glycerol / water mixed solution containing glycolic acid at a mass ratio of 1:5-15.

[0021] Further, the stirring extraction time in step (2) is 2-4 hours, and the supernatant is obtained by centrifuging the extracted mixture at 5000-10000 rpm for 10-30 minutes to obtain mung bean seed extract.

[0022] Mung bean seed extract has moisturizing, anti-inflammatory, and anti-allergic effects. It can inhibit the release of inflammatory mediators to reduce skin allergic reactions, soothe irritated skin, and rebuild a healthy lipid barrier, providing long-lasting skin relief. The composition of this invention uses mung bean seed extract as the main ingredient, and its redness-reducing and repairing effects are enhanced through multi-component synergy and a specific preparation process.

[0023] The glycerophosphoinositol choline (GPI) used in this invention is a semi-synthetic derivative of glycerophosphoinositol, a natural cellular component produced by lipid metabolism. It can prevent the production of advanced glycation end products (AGEs) of inflammation caused by the glycosylation of proteins such as transcription factor NF-κB, collagen, and enzymes; and reduce the transcription of inflammatory and aging factors by inhibiting the transfer of NF-κB to the nucleus. As a natural phospholipid derivative, it can promote normal differentiation of keratinocytes, enhance epidermal barrier function, and reduce water loss.

[0024] The molecular structure of GPI is shown below:

[0025]

[0026] This invention utilizes GPI to further synergistically enhance the redness-reducing and repairing effects of mung bean seed extract.

[0027] Further, the mass ratio of the glycerophosphate inositol choline salt to oat kernel extract and mung bean seed extract in step (3) is 1-2:20-40:59-79.

[0028] A redness-reducing and repairing composition was prepared by the above method.

[0029] Application of the above-mentioned redness-reducing and repairing composition in cosmetics.

[0030] Furthermore, the cosmetic product is a redness-reducing and repairing essence, and its formula composition by weight percentage is as follows:

[0031] The redness-reducing and repairing composition comprises 10-40% 1,3-butanediol 3-8%, D-panthenol 1-3%, glyceryl stearate and / or PEG-100 stearate 1-2%, allantoin 0.5-2%, 1,2-hexanediol 0.5-1%, p-hydroxyacetophenone 0.2-1%, jojoba oil 0.2-1%, ammonium acryloyldimethyl taurate / VP copolymer 0.1-0.3%, hyaluronic acid 0.1-0.2%, vitamin E (VE) 0.05-0.2%, and the balance being water.

[0032] Compared with the prior art, the beneficial effects of the present invention are:

[0033] (1) The redness-reducing and repairing composition of the present invention uses mung bean seed extract, which is widely available and low in cost, as the main raw material. Through the synergistic effect of oat kernel extract and GPI, it can achieve a significantly improved redness-reducing and repairing effect.

[0034] (2) The present invention further uses a specific process to prepare mung bean seed extract, which can further improve the redness-reducing and repairing effects of the obtained composition. Detailed Implementation

[0035] The present invention will be further described in detail below with reference to embodiments, but the implementation of the present invention is not limited thereto.

[0036] Example 1

[0037] A method for preparing a redness-reducing and repairing composition includes the following preparation steps:

[0038] (1) Preparation of oat kernel extract: Oat kernels (unripe) were crushed and passed through a 60-mesh sieve and then extracted with pure water at a mass ratio of 1:30. After extraction at 85-95℃ for 2 hours, the extract was naturally cooled and refrigerated at 4℃ for 24 hours. The supernatant was collected by centrifugation at 8000rpm*15min to obtain oat kernel extract (hereinafter referred to as AS).

[0039] (2) Preparation of mung bean seed extract: Fresh mung beans were added to a 30% (w / w) glycerol / water mixed solution with a material-to-liquid mass ratio of 1:10. Glycolic acid was added to adjust the pH to 5.0. Then, the mixture was crushed, dispersed and homogenized with a high-speed homogenizer until no particles were present. The temperature was controlled at 4-10℃ and stirred for 3 hours. The supernatant was collected by centrifugation at 8000 rpm for 15 minutes to obtain mung bean seed extract (hereinafter referred to as VR).

[0040] (3) Glycerol phosphate inositol choline (GPI) was mixed with oat kernel extract (AS) and mung bean seed extract (VR) in a mass ratio of 1:20:79 to obtain a redness-reducing and repairing composition.

[0041] Examples 2-6 and Comparative Examples 1-5

[0042] The preparation methods of redness-reducing and repairing compositions in Examples 2-6 and Comparative Examples 1-5 are the same as those in Example 1, except that the raw material ratio in step (3) is adjusted according to Table 1.

[0043] Table 1. Raw material ratios for Examples 1-6 and Comparative Examples 1-5

[0044] Example / Comparative Example Raw Material Ratio % (w / w) Example 1 GPI:AS:VR 1:20:79 Example 2 GPI:AS:VR 0.1:20:79.9 Example 3 GPI:AS:VR 2:20:78 Example 4 GPI:AS:VR 1:40:59 Example 5 GPI:AS:VR:water 1:10:79:10 Example 6 GPI:AS:VR:water 1:20:50:29 Comparative Example 1 GPI:water 2:98 Comparative Example 2 AS:water 40:60 Comparative Example 3 VR 100 Comparative Example 4 GPI:VR 1:99 Comparative Example 5 AS:VR 20:80

[0045] Comparative Example 6

[0046] A method for preparing a redness-reducing and repairing composition includes the following preparation steps:

[0047] (1) The preparation of oat kernel extract is the same as in Example 1.

[0048] (2) Preparation of mung bean seed extract: Fresh mung beans were added to pure water at a mass ratio of 1:10. Then, the mixture was crushed, dispersed and homogenized with a high-speed homogenizer until no particles were present. The temperature was controlled at 4-10℃ and the mixture was stirred and extracted for 3 hours. The supernatant was collected by centrifugation at 8000 rpm for 15 minutes to obtain mung bean seed extract (VR).

[0049] (3) The preparation method of the redness-reducing and repairing composition is the same as that in Example 1.

[0050] Performance Test 1: Redness Reduction Test

[0051] Experiments were conducted on the products prepared in the examples and comparative examples, with 8 subjects for each product. The subjects were healthy women (i.e., non-allergic) aged between 20 and 53.

[0052] Usage: After cleansing your face daily, apply an appropriate amount of product to your face twice a day, morning and evening, for 7 consecutive days.

[0053] The Visia 7 skin image analysis system was used to detect and analyze all facial aging and lesions from the epidermis to the dermis through photography. The red area mainly analyzes the red area of ​​the facial dermis, which represents the location, number, shape, size and clinical severity of red blood vessels. The higher the measurement value, the more severe the inflammation.

[0054] The improvement rate in the red zone was calculated by comparing the values ​​on day 7 after product use, day 10 after product discontinuation, and the initial values ​​before product use.

[0055] The formula for calculating the improvement rate in the red zone is: {(red discrimination value of the subject before use - red discrimination value of the same subject after 7 days / 10 days of use) / red discrimination value of the subject before use} × 100%.

[0056] The test results are shown in Table 2 below:

[0057] Table 2. Redness reduction test results of Examples 1-6 and Comparative Examples 1-6

[0058]

[0059]

[0060] The test results show that Examples 1 and 3 are highly effective. Considering the usage limits and cost of GPI, the overall optimal ratio of GPI:AS:VR is 1:20:79. Furthermore, the comparison between Comparative Examples 1-5 and the Examples shows that GPI, AS, and VR in the composition of this invention have a significant synergistic effect in reducing redness; the absence of any component or a reduction in its content leads to a significant decrease in the redness-reducing effect. Additionally, the comparison between Comparative Example 6 and Example 1 shows that the composition prepared using the mixed solvent of glycerol and water of this invention for extraction, and the composition prepared by extracting VR under acidic conditions of glycolic acid, exhibits significantly improved redness-reducing efficacy.

[0061] The experimental results also showed that there were no significant fluctuations in the data after 3 days of discontinuation (compared to 7 days of use). This further demonstrates the effectiveness in reducing redness, and there was no recurrence.

[0062] Performance Test 2: Repair Effect Test

[0063] The test subjects and methods for performance test 2 are the same as those for performance test 1. The difference lies in the testing methods. The specific testing methods for the repair effect are as follows:

[0064] Data on transepidermal water loss rate of the subject's cheek skin were measured using the Tewameter™ Hex probe. A lower measurement value indicates less transepidermal water loss per unit time and unit cross-sectional area, signifying a better skin barrier. Data on transepidermal water loss rate were analyzed on day 7 of product use, day 10 after discontinuation, and before product use. The formula for calculating the improvement rate of transepidermal water loss rate was: {(Transepidermal water loss rate of the subject's skin before use - Transepidermal water loss rate of the same area of ​​the same subject after 7 (10) days of use) / Transepidermal water loss rate of the subject's skin before use} × 100%.

[0065] The test results are shown in Table 3 below:

[0066] Table 3. Test results of repair effects in Examples 1-6 and Comparative Examples 1-6

[0067]

[0068] The above results show that GPI, AS, and VR in the composition of the present invention have a significant synergistic effect in repair efficacy, and the absence of any one of these components will lead to a significant reduction in repair efficacy. Furthermore, the comparison between Comparative Example 6 and Example 1 shows that the composition prepared using the mixed solvent of glycerol and water of the present invention for extraction, and the composition prepared by extracting VR under acidic conditions of glycolic acid, has significantly improved repair efficacy.

[0069] The transdermal water loss value did not increase significantly after 3 days of discontinuation, indicating that the skin barrier was improved.

[0070] Performance Test 3: Formula Application and Redness Relief and Soothing Effects

[0071] The test subjects and methods for performance test 3 are the same as those for test example 1, except for the testing methods. The specific testing method for the redness-reducing and soothing effect is as follows:

[0072] A facial image analyzer was used to analyze the α value of the red area on the cheek using IPP. The higher the measured value, the more severe the skin redness.

[0073] The formula for calculating the improvement rate of the α-value is: {(red zone α-value of the subject before use - red zone α-value of the same subject 7 days later) / red zone α-value of the subject before use} × 100%.

[0074] The test formulations are shown in Table 4 below:

[0075] Table 4 Application Formula Table

[0076]

[0077]

[0078] The corresponding test results are shown in Table 5 below:

[0079] Table 5. Application effect test results of Examples 1-6 and Comparative Examples 1-6

[0080]

[0081]

[0082] Table 5 shows that Examples 1 and 3 exhibit the best application performance, showing a certain positive correlation with the results of Performance Test 1. Simultaneously, the compositions of the present invention also demonstrate a significant synergistic effect in reducing redness and soothing sensitivity within the formulation. Furthermore, the compositions prepared using the mixed solvent of glycerol and water of the present invention, and those prepared by extraction under acidic conditions of glycolic acid, show significantly enhanced redness-reducing efficacy, consistent with the results of Performance Test 1. Even though the amount of composition used in the application formulation (30%) is far less than that used in Performance Test 1, this may be related to the formulation itself.

[0083] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A method of preparing a redness-reducing treatment composition, characterized in that, It comprises the following preparation steps: (1) Preparation of oat kernel extract: after the oat kernel is crushed and sieved, it is extracted with pure water at an extraction temperature of 85-95°C to obtain the oat kernel extract; (2) Preparation of mung bean seed extract: fresh mung beans are added to a glycerol / water mixed solution containing glycolic acid, the mass percentage of glycerol in the mixed solution is 20-40%, and the content of glycolic acid is such that the pH value of the mixed solution is 4.5-6; the mixture is broken and dispersed by a high-speed homogenizer until no particles are present, and then it is stirred for extraction under low-temperature conditions of 4-10°C to obtain the mung bean seed extract; (3) The glycerophosphoinositol choline salt is mixed with the oat kernel extract and the mung bean seed extract in a mass ratio of 0.1-2:10-40:50-80 to obtain the redness-reducing and repairing composition.

2. The method of claim 1, wherein the red fade repair composition is prepared by the steps of: In step (1), the crushing and sieving refers to passing through a 60-mesh sieve.

3. The method of claim 1, wherein the red fade repair composition is prepared by the steps of: In step (1), the mass ratio of the material to the liquid in the pure water extraction is 1:20-40, and the extraction time is 1-3 h.

4. The method of claim 3, wherein the red fade repair composition is prepared by mixing the red fade repair composition with water in a ratio of 1 : 1 to 1 :

10. After the mixed solution after the pure water extraction is naturally cooled, it is stored at 0-4°C for 12-36 h, and then it is centrifuged at 5000-10000 rpm for 10-30 min to obtain the oat kernel extract.

5. The method of claim 1, wherein the red fade repair composition is prepared by the steps of: In step (2), the mass ratio of the fresh mung beans to the liquid in the glycerol / water mixed solution containing glycolic acid is 1:5-15; the stirring extraction time is 2-4 h, and then the mixed solution after the extraction is centrifuged at 5000-10000 rpm for 10-30 min to obtain the mung bean seed extract.

6. The method of claim 1, wherein the red fade repair composition is prepared by the steps of: In step (3), the mass ratio of the glycerophosphoinositol choline salt to the oat kernel extract and the mung bean seed extract is 1-2:20-40:59-79.

7. A redness-reducing treatment composition characterized in that, It is prepared by the method of any one of claims 1-6.

8. Use of the redness-reducing and repairing composition of claim 7 in the preparation of a cosmetic product.

9. Use of a redness-reducing repair composition according to claim 8 for the manufacture of a cosmetic product, characterized in that, The cosmetic product is a redness-reducing and repairing essence, and the mass percentage composition of the formula is as follows: The redness-reducing and repairing composition of claim 7 is 10-40%, 1,3-butanediol is 3-8%, D-panthenol is 1-3%, glyceryl stearate and / or PEG-100 stearate is 1-2%, allantoin is 0.5-2%, 1,2-hexanediol is 0.5-1%, p-hydroxyacetophenone is 0.2-1%, jojoba oil is 0.2-1%, acryloyldimethyltauramide / VP copolymer is 0.1-0.3%, hyaluronic acid is 0.1-0.2%, vitamin E is 0.05-0.2%, and the balance is water.

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