External medicine for treating various skin diseases

Abstract

The invention discloses an external medicine for treating various skin diseases, and relates to the technical field of external medicines for the dermatology department. The mask has a remarkable curative effect on tinea of hands and feet, scalds and infectious wounds, the raw materials are easy to obtain, and the cost is low. The agent is prepared from castor oil, sulfur and quick lime through a special process. The core technology comprises the following steps: gradient temperature control boiling: activating castor oil at 130 DEG C, vulcanizing and cracking at 85 DEG C, and calcifying lime at 105 DEG C; forming a functional compound in situ: sulfurized ricinoleate (antifungal) and nano calcium hydroxide (antibacterial and healing-promoting); safe cooling and filtering: filtering with cotton cloth below 50 DEG C to remove irritant particles; and sulfur and ricinoleic acid react to generate sulfurized ricinoleic acid ester through a temperature-controlled decocting and gradient adding process, and meanwhile, the lime forms a nano calcium hydroxide colloid in an oil phase.

Description

Technical Field

[0001] The present invention relates to the technical field of dermatological external-use medicines, in particular to an external-use medicine for treating various skin diseases. Background Art

[0002] Skin diseases refer to pathological conditions that occur in the skin, hair, nails, and underlying tissues. Causes range from infection to immunity, metabolism, genetics, and physical / chemical damage. Topical medications are pharmaceutical preparations that are applied or sprayed directly onto the skin to treat localized skin problems without systemic side effects.

[0003] In the process of realizing the present invention, the inventors found that the existing technology has the following problems: Treatment of tinea pedis and tinea manuum: Commonly used azole antifungal drugs (such as ketoconazole) are prone to drug resistance and are ineffective against chapped tinea; Treatment of burns: Sulfadiazine silver cream may cause silver poisoning, and the cost of biological dressings is high; Wound repair: Long-term use of antibiotic ointments (such as mupirocin) destroys the skin microecology. Summary of the Invention

[0004] In response to the deficiencies of the existing technology, the present invention provides an external-use medicine for treating a variety of skin diseases, solving the existing problems in the treatment of tinea pedis and tinea manuum: commonly used azole antifungal drugs (such as ketoconazole) are prone to drug resistance and are ineffective against chapped tinea; burn treatment: sulfadiazine silver cream may cause argyria poisoning, and biological dressings are expensive; wound repair: long-term use of antibiotic ointments (such as mupirocin) damages the skin microecology.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solution: an external-use medicine for treating various skin diseases, which is prepared from the following raw materials in parts by weight:

[0006] 30-50 parts of castor oil, 10-17 parts of sulfur, 10-17 parts of quicklime;

[0007] Preferred:

[0008] The quicklime is calcium oxide (CaO) obtained by calcining limestone, with a purity of ≥90%;

[0009] The sulfur is refined sulfur powder with a sulfur content of ≥99.5%.

[0010] Preferably, the method comprises the following steps:

[0011] (1) Heat castor oil to 120-130°C and hold for 1-2 minutes;

[0012] (2) Add sulfur powder and simmer over medium-low heat at 80-90°C for 3-5 minutes;

[0013] (3) Add quicklime powder, heat to 100-110°C, boil and then stop heating;

[0014] (4) Cool naturally to 45-50°C and filter through 200-mesh cotton cloth;

[0015] (5) Add auxiliary materials: add borneol accounting for 1-5% of the total amount or menthol 0.5-2% of the total amount.

[0016] Preferably, the invention is used in the preparation of medicines for treating tinea pedis, burns and skin contusions.

[0017] Mechanism of action

[0018] Composition: Sulfur, converted into pentasulfide (S5 2 -), destroying fungal keratinase

[0019] Quicklime, generates Ca(OH)2 colloid, maintains pH 9-10 antibacterial environment

[0020] Castor oil, ricinoleic acid complexed with sulfur / calcium to form a transdermal carrier system

[0021] Process innovation advantages

[0022] Step-by-step temperature control addition:

[0023] Add sulfur first (80-90℃): promote the opening of sulfur ring to form active sulfide;

[0024] Add lime later (100-110℃): to avoid premature hydration and heat release of CaO;

[0025] Filtration below 50℃: intercept unreacted lime particles to prevent local strong alkali damage;

[0026] Cotton cloth filtration: adsorbs macromolecular polymers and improves the stability of the preparation.

[0027] Beneficial effects

[0028] This invention provides a topical medication for treating a variety of skin diseases. It exhibits significant efficacy for tinea pedis, burns, and infectious wounds, and utilizes readily available, low-cost raw materials. It is manufactured using a special process involving castor oil, sulfur, and quicklime. The core technology includes gradient temperature-controlled boiling, in-situ formation of a functional complex, and safe cooling and filtration. Through this temperature-controlled boiling combined with a gradient addition process, sulfur reacts with ricinoleic acid to form ricinoleic acid sulfide, while the lime simultaneously forms nano-calcium hydroxide colloids in the oil phase. DETAILED DESCRIPTION

[0029] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] The present invention provides a technical solution: an external-use medicine for treating various skin diseases, which is prepared from the following raw materials in parts by weight:

[0031] 30-50 parts of castor oil, 10-17 parts of sulfur, 10-17 parts of quicklime;

[0032] This embodiment is further configured as follows:

[0033] The quicklime is calcium oxide (CaO) obtained by calcining limestone, with a purity of ≥90%;

[0034] The sulfur is refined sulfur powder with a sulfur content of ≥99.5%.

[0035] This embodiment is further configured to include the following steps:

[0036] (1) Heat castor oil to 120-130°C and hold for 1-2 minutes;

[0037] (2) Add sulfur powder and simmer over medium-low heat at 80-90°C for 3-5 minutes;

[0038] (3) Add quicklime powder, heat to 100-110°C, boil and then stop heating;

[0039] (4) Cool naturally to 45-50°C and filter through 200-mesh cotton cloth;

[0040] (5) Add auxiliary materials: add borneol accounting for 1-5% of the total amount or menthol 0.5-2% of the total amount.

[0041] This embodiment is further configured to be used in the preparation of medicines for treating tinea pedis, burns, and skin contusions.

[0042] The detailed connection means are well-known technologies in this field. The following mainly introduces the working principle and process. The specific operations are as follows.

[0043] Example: Basic formula

[0044] Ingredients: 40g castor oil, 13g sulfur, 13g quicklime

[0045] Steps: Boil castor oil at 130℃ for 2 minutes; add sulfur and stir at 85℃ for 4 minutes until it turns orange-red; add quicklime powder and boil at 105℃ for 1 minute before turning off the heat; cool to 48℃ and filter through cotton cloth to obtain an orange-yellow ointment.

[0046] Synergistic formula

[0047] The filtrate of Example 1 was added with: 1.2g of borneol (antipruritic and penetrating) and 0.5g of baicalin (anti-inflammatory). Wound and infection: The bacterial clearance rate of the present invention group was 98.3% vs. 91.7% in the mupirocin group;

[0048] Mechanism: Ca(OH)2 continuously releases OH- to destroy the biofilm, and sulfur blocks the formation of biofilm.

[0049] The skin is bruised or broken, and there are minor skin injuries. After applying it, it will not get infected and will peel off. The wound will heal quickly, reduce swelling, relieve pain, prevent bacterial infection, and leave no scars.

[0050] If you have peeling skin ringworm and tinea pedis, apply it twice a day for a few days and the symptoms will disappear.

[0051] It should be noted that, in this document, relational terms such as first and second, etc. are merely used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations.

Claims

1. A medicine for external use for treating various skin diseases, characterized in that: It is prepared from the following raw materials in parts by weight: 30-50 parts of castor oil, 10-17 parts of sulfur, and 10-17 parts of quicklime.

2. The external medicine according to claim 1, characterized in that: The quicklime is calcium oxide (CaO) obtained by calcining limestone, with a purity of ≥90%; The sulfur is refined sulfur powder with a sulfur content of ≥99.5%.

3. The method for preparing the external medicine according to any one of claims 1-2, comprising the following steps: (1) Heat castor oil to 120-130°C and hold for 1-2 minutes; (2) Add sulfur powder and simmer over medium-low heat at 80-90°C for 3-5 minutes; (3) Add quicklime powder, heat to 100-110°C, boil and then stop heating; (4) Cool naturally to 45-50°C and filter through 200-mesh cotton cloth; (5) Add auxiliary materials: add borneol accounting for 1-5% of the total amount or menthol 0.5-2% of the total amount.

4. Use of the external-use medicine according to any one of claims 1 to 3 in preparing medicines for treating tinea manuum, pedis, burns, and skin contusions.