Corn active peptide with effects of dispelling effects of alcohol, reducing uric acid and resisting oxidation, preparation and application of corn active peptide

By isolating and screening corn active peptides such as LMFP, FEGLFR, FLR and QLPSYR from corn germ meal, the adverse reaction problems of hyperuricemia and alcoholic liver disease in the existing technology have been solved, and the development of products with alcohol-relieving, uric acid-lowering and antioxidant effects has been achieved, which has significant biological activity and application potential.

CN120699098AActive Publication Date: 2025-09-26QINGDAO AGRI UNIV
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Patent Information

Application Number
CN202511231839.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-01
Publication Date
2025-09-26
Estimated Expiration
2045-09-01

AI Technical Summary

Technical Problem

Existing drugs for the treatment of hyperuricemia and alcoholic liver disease have adverse reactions, and there is a lack of effective targeted therapeutic drugs. The development of bioactive peptides in corn germ meal protein has not been fully utilized.

Method used

Corn active peptides with alcohol-relieving, uric acid-lowering and antioxidant effects are separated from corn germ meal through enzymatic hydrolysis, ultrafiltration and other technologies. The amino acid sequences are LMFP, FEGLFR, FLR and QLPSYR. They are used in food, medicine or health products. They achieve alcohol-relieving and uric acid-lowering effects by increasing the ADH activation rate and XOD inhibition rate, and have a DPPH free radical scavenging effect.

Benefits of technology

The obtained corn active peptides show significant alcohol-relieving, uric acid-lowering and antioxidant effects in food, medicine and health products. They have good XOD inhibition rate, DPPH clearance rate and ADH activation rate, and have important application prospects as natural antioxidants and uric acid-lowering supplements.

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Abstract

The invention discloses a corn active peptide with effects of dispelling effects of alcohol, reducing uric acid and resisting oxidation, a preparation and application of the corn active peptide, and belongs to the technical field of biological active peptides. The amino acid sequence of the corn active peptide is at least one of LMFP, FEGLFR, FLR and QLPSYR. The corn active peptide with the effects of dispelling the effects of alcohol, reducing uric acid and resisting oxidation is separated from corn germ meal through enzymolysis, ultrafiltration and other technologies, amino acid sequence determination is conducted on the separated peptide fragments, screening is conducted in combination with the bioinformatics technology, and finally four peptide fragments are obtained. According to the present invention, the corn active peptides are identified, chemical synthesis is performed according to the identified peptide fragment sequence, the effects of alcohol effect dispelling, uric acid reducing and oxidation resistance of the synthesized single peptide fragment and the compounded peptide fragment are determined, and the corn active peptides have good XOD inhibition rate, good DPPH clearance rate and good ADH activation rate, and have important application prospects in the development of the products with effects of alcohol effect dispelling, uric acid reducing and oxidation resistance.
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