Sweat collection detection device and method

Abstract

This invention discloses a sweat collection and detection device and method, comprising: a shell capable of adsorbing onto the skin surface, a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and a sensor; the method includes: setting the air pressure inside the shell to allow the shell to adsorb onto the skin surface; setting the temperature inside the shell to promote sweat gland secretion; and using the MCU to acquire the set indicators in the sweat collected by the microfluidic chip, detected by the sensor. This invention discloses a sweat collection and detection device and method that can adsorb onto the surface of human skin, offering excellent convenience and requiring no invasive operation. Simultaneously, this device utilizes a microfluidic chip to collect sweat from the human skin surface, improving the quality and efficiency of sweat collection. Furthermore, this device can promote the secretion of sweat from localized skin through heating, effectively solving the problem of the inability to produce sweat in special environments, thus hindering sweat detection.

Description

Technical Field

[0001] This invention belongs to the field of biomedical engineering, and in particular relates to a sweat collection and detection device and method. Background Technology

[0002] Wearable sensing technology can continuously monitor an individual's health status, which is crucial for realizing personalized medicine. In recent years, with the rapid development of wearable electronic devices, it has become possible to accurately measure vital signs such as heart rate, body temperature, and blood pressure. However, these physiological parameters cannot reflect direct information about the body's metabolic processes. Human sweat contains abundant metabolic substances and can be collected relatively easily and non-invasively from the skin surface, thus holding great potential in health diagnosis and exercise monitoring. According to relevant research, sweat indicators are highly correlated with physiological indicators of blood and urine. Therefore, collecting sweat physiological indicators can effectively avoid the cumbersome blood sampling procedure. However, under current technological conditions, how to conveniently, quickly, and pollution-free collect and test sweat is an urgent problem that needs to be solved. Summary of the Invention

[0003] In view of this, the present invention aims to overcome the defects in the prior art and proposes a sweat collection and detection device and method.

[0004] To achieve the above objectives, the technical solution of the present invention is implemented as follows:

[0005] In a first aspect, the present invention discloses a sweat collection and detection device, comprising: a shell capable of being adsorbed onto the skin surface; the shell is provided with a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and a sensor;

[0006] The pressure module is connected to the microcontroller unit (MCU). The pressure module is used to adjust the pressure difference between the inside and outside of the housing, so that the housing can adhere to or leave the skin surface.

[0007] The heating module is connected to the microcontroller unit (MCU). The heating module is used to increase the temperature inside the housing, causing sweat to be generated on the skin surface.

[0008] The microfluidic chip comes into contact with the skin surface and is used to collect sweat generated on the skin surface;

[0009] The sensor is connected to the microcontroller unit (MCU) and is used to detect set parameters in the sweat collected by the microfluidic chip.

[0010] In one implementation of the present invention, the pressure module includes a pressure sensor and an air pump; the pressure sensor is used to collect the internal air pressure of the housing, and the microcontroller unit (MCU) controls the start and stop of the air pump based on a predetermined comparison result between the external air pressure and the internal air pressure, and the air pump can discharge the air inside the housing.

[0011] In one implementation of the present invention, the heating module includes a temperature sensor and a heating resistance wire; the heating resistance wire and the temperature sensor are respectively connected to a microcontroller unit (MCU); the temperature sensor is used to collect the internal temperature of the housing, the heating resistance wire is used to heat the internal space of the housing, and the MCU controls the operating current of the heating resistance wire based on the comparison result between the internal temperature and a set threshold.

[0012] In one implementation of the present invention, the sensor is a glucose sensor.

[0013] In one implementation of the present invention, the sensor is a lactic acid sensor.

[0014] In one implementation of the present invention, the sensor is a pH sensor.

[0015] In one implementation of the present invention, the device further includes: a signal generator; the signal generator outputs an excitation signal to an auxiliary port of a constant potential circuit, the constant potential circuit being connected to a sensor.

[0016] In one implementation of the present invention, the microfluidic chip is a polydimethylsiloxane (PDMS) material microfluidic chip.

[0017] In one implementation of the present invention, the microcontroller unit (MCU) controls the operating current of the heating resistor wire through a power controller.

[0018] Secondly, this invention discloses a sweat collection and detection method, using the aforementioned sweat collection and detection device, comprising:

[0019] Set the air pressure inside the shell to allow it to adhere to the skin surface;

[0020] Set the temperature inside the casing to promote sweat gland secretion;

[0021] Using a microcontroller unit (MCU), the system acquires set parameters from the sweat collected by the microfluidic chip and detected by sensors.

[0022] Compared with the prior art, the present invention has the following advantages:

[0023] This invention discloses a sweat collection and detection device and method, comprising: a shell capable of adsorbing onto the skin surface, a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and a sensor; the method includes: setting the air pressure inside the shell to allow the shell to adsorb onto the skin surface; setting the temperature inside the shell to promote sweat gland secretion; and using the MCU to acquire the set indicators in the sweat collected by the microfluidic chip as detected by the sensor. This invention discloses a sweat collection and detection device and method that can adsorb onto the surface of human skin, offering excellent convenience and requiring no invasive operation. Furthermore, this device utilizes a microfluidic chip to collect sweat from the human skin surface, improving the quality and efficiency of sweat collection. Moreover, this device can promote the secretion of sweat from localized skin through heating, effectively solving the problem of the inability to produce sweat in special environments, thus hindering sweat detection. Attached Figure Description

[0024] The accompanying drawings, which form part of this invention, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an improper limitation of the invention.

[0025] In the attached diagram:

[0026] Figure 1 This is a schematic diagram of a sweat collection and detection device according to an embodiment of the present invention;

[0027] Figure 2 This is a schematic diagram of a microcontroller unit (MCU) for a sweat collection and detection device according to an embodiment of the present invention;

[0028] Figure 3 This is a schematic diagram of a microfluidic chip for a sweat collection and detection device according to an embodiment of the present invention;

[0029] Figure 4 This is a structurally exploded diagram of a microfluidic chip relative to the skin in a sweat collection and detection device according to an embodiment of the present invention;

[0030] Figure 5 This is a schematic diagram of the internal components of a sweat collection and detection device according to an embodiment of the present invention. Detailed Implementation

[0031] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other.

[0032] In the description of this invention, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0033] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art will understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0034] In the description of this invention, it should be further noted that the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0035] Under current technological conditions, how to conveniently, quickly, and pollution-free collect and detect sweat is an urgent problem that needs to be solved. This invention discloses a sweat collection and detection device and method, comprising: a shell capable of adsorbing onto the skin surface, a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and a sensor. This sweat collection and detection device can be adsorbed onto the surface of human skin, offering excellent convenience. Simultaneously, this device utilizes a microfluidic chip to collect sweat from the human skin surface, improving the quality and efficiency of sweat collection. Furthermore, this device can promote the secretion of sweat from localized skin through heating, effectively solving the problem of the inability to produce sweat under special environmental conditions, thus hindering sweat detection.

[0036] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0037] In one embodiment of the present invention, such as Figure 1As shown, the present invention discloses a sweat collection and detection device, comprising: a shell capable of adsorbing onto the skin surface; the shell is equipped with a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and a sensor;

[0038] The pressure module is connected to the microcontroller unit (MCU). The pressure module is used to adjust the pressure difference between the inside and outside of the housing, so that the housing can adhere to or leave the skin surface.

[0039] The heating module is connected to the microcontroller unit (MCU). The heating module is used to increase the temperature inside the housing, causing sweat to be generated on the skin surface.

[0040] The microfluidic chip comes into contact with the skin surface and is used to collect sweat generated on the skin surface;

[0041] The sensor is connected to the microcontroller unit (MCU) and is used to detect set parameters in the sweat collected by the microfluidic chip.

[0042] Based on the previous embodiment, in one embodiment of the present invention, such as Figure 2 As shown, the pressure module includes a pressure sensor and an air pump. The pressure sensor is used to collect the internal air pressure of the housing. The microcontroller unit (MCU) controls the start and stop of the air pump based on the pre-determined comparison result between the acquired external air pressure and the internal air pressure. The air pump can expel the air from inside the housing.

[0043] Based on the previous embodiment, in one embodiment of the present invention, such as Figure 2 As shown, the heating module includes a temperature sensor and a heating resistance wire; the heating resistance wire and the temperature sensor are respectively connected to the microcontroller unit (MCU); the temperature sensor is used to collect the internal temperature of the housing, the heating resistance wire is used to heat the internal space of the housing, and the MCU controls the operating current of the heating resistance wire based on the comparison result between the internal temperature and the set threshold.

[0044] In this embodiment, the sensor is a combination of three sensors: a glucose sensor, a lactic acid sensor, and a pH sensor.

[0045] Based on the previous embodiment, in one embodiment of the present invention, such as Figure 1 As shown, the device also includes: a signal generator; the signal generator outputs an excitation signal to the auxiliary port of the constant potential circuit, and the constant potential circuit is connected to the sensor.

[0046] In this embodiment, as Figure 4As shown, the microfluidic chip may include an adhesive layer, a microfluidic channel layer, and a sweat sensor, arranged sequentially from near to far from the skin. The adhesive layer can be a flexible medical tape with good skin compatibility, such as fiber-filled polyester adhesive transfer tape, which facilitates close adhesion to the skin surface and forms a relatively sealed space together with the housing. An inlet can be provided on the adhesive layer, through which sweat enters the microfluidic channel. The microfluidic channel layer can be made of polydimethylsiloxane (PDMS) material, making the microfluidic chip more flexible and conforming to the skin, facilitating the collection of human sweat.

[0047] In this embodiment, the microcontroller unit (MCU) controls the operating current of the heating resistor wire through a power controller.

[0048] The microcontroller unit (MCU) is the control center of this device. It receives signals from the temperature and pressure sensors and adjusts the operating status of the heating element and the air pump based on these signals. The temperature sensor monitors the internal temperature of the housing in real time and sends the results to the MCU. The pressure sensor monitors the internal pressure of the housing in real time and sends the results to the MCU. The heating element is the heat-generating component in this device; its operating status is adjusted by the MCU based on feedback from the temperature sensor to maintain the internal temperature of the housing within a preset range. The air pump controls the internal pressure of the housing, which is adjusted in real time by the MCU based on feedback from the pressure sensor to maintain a stable internal pressure. Figure 5 As shown, the internal components of the housing may include: an air pump, a pressurization control circuit, thermal insulation material, a PTC heating pad, a heating control circuit, and a microfluidic chip. The pressurization control circuit integrates a pressure module that adjusts the adsorption intensity based on air pressure feedback, ensuring a flexible fit between the device and the skin. This allows the microfluidic chip at the bottom layer to adhere tightly to the skin surface, enabling the collection of sweat. The heating module employs a PID temperature control algorithm to heat the target area at a constant power, thereby activating sweat gland secretion.

[0049] For example, the current output pin is fine-tuned and compensated by the power controller to adjust the magnitude of the current flowing through the heating resistor wire. This involves generating a PWM waveform to act on the power controller, and the process includes:

[0050] ① Set the target temperature Ts that you want to maintain inside the housing of this device;

[0051] ② During the control cycle, the temperature sensor continuously detects the instantaneous internal temperature Tm of the housing and calculates the error e(t) between the current temperature Tm and the target temperature Ts, as follows:

[0052] ;

[0053] Where t represents time;

[0054] ③ Based on the sampling rate of the temperature sensor, initialize the relevant system constants, with the proportional gain denoted as K. P The integral gain is represented by K. i The differential gain is expressed as K d The integral time constant represents T. i The differential time constant represents T. d ;

[0055] ④ The control signal u(t) is output through the PID algorithm as follows: ;

[0056] Where t represents time;

[0057] ⑤ Repeat steps ① to ④ of the above process for the next control cycle.

[0058] Furthermore, the process for controlling the internal air pressure of the casing is as follows:

[0059] ① By external detection, the atmospheric pressure PA in the external environment of the shell is obtained, and the target pressure difference P that can meet the adsorption purpose of the shell is determined. Z ;

[0060] ② During the control cycle, the current internal pressure Ph inside the shell is continuously monitored, and the error e(t) between the current internal pressure and the target pressure is calculated:

[0061] ;

[0062] Where t represents time;

[0063] ③ Based on the sampling rate of the pressure sensor, initialize the relevant constants of the pressure control loop; the proportional gain is expressed as K. P The integral gain is represented by K. i The differential gain is expressed as K d The integral time constant represents T. i The differential time constant represents T. d ;

[0064] ④ The control signal u(t) is output through the PID algorithm as follows:

[0065] ;

[0066] Where t represents time;

[0067] ⑤ Repeat steps ① to ④ of the above process for the next control cycle.

[0068] Based on the previous embodiment, in another embodiment of the present invention, such as Figure 3 As shown:

[0069] The microfluidic chip includes interconnected inlets, microfluidic channels, a reservoir, flow resistance, and outlets. The inlet is where sweat enters the microfluidic channels, and its main function is to guide and control the sweat inlet. The microfluidic chip is designed with a uniform array of 500μm diameter circular inlets to ensure accurate and sufficient skin coverage. The number of uniformly arrayed inlets was optimized, and ultimately, eight uniformly arrayed 500μm diameter circular inlets were selected in the multi-channel sweat collection microfluidic chip. The multi-channel sweat collection microfluidic chip has good flowability.

[0070] Microfluidic channels are the primary flow regions, and their function is to control the mixing, transport, and reaction of fluids by designing their shape and width. The sweat rise height H and pressure drop VP within the microfluidic channel can be designed as follows:

[0071] ;

[0072] ;

[0073] Where σ is the surface tension of sweat on the PDMS surface, θ is the wetting angle of sweat on the inner wall of the capillary, r is the capillary radius, ρ is the sweat density, g is the acceleration due to gravity; μ is the dynamic viscosity of sweat, L is the length of the microfluidic channel; h0 is the initial height of the microfluidic channel, which refers to the vertical dimension of the channel; and w is the width of the microfluidic channel.

[0074] In the design of microfluidic channels, w should be greater than 100μm to avoid high pressure drop, and w should not exceed 200μm to avoid sweat evaporation.

[0075] The main function of the liquid reservoir is to maintain a stable liquid supply, avoiding problems such as insufficient and uneven reaction caused by the short residence time of liquid in traditional channel structures. The size of the liquid reservoir is consistent with the size of the sensor, and the sensor and the liquid reservoir are aligned in the center. This reduces the impact of alignment errors on the offset of the two pattern areas, and achieves a close fit between the liquid reservoir and the sensor in the flow channel layer of the microfluidic chip for multi-channel sweat collection.

[0076] Flow resistance is a key design parameter in the microfluidic chip for multi-channel sweat collection. By reasonably adjusting the flow resistance, the flow rate of the collected sweat can be controlled, mixing and diffusion can be promoted, separation and grading can be achieved, pressure loss can be reduced, and mass transfer efficiency can be improved, providing important support for the effective and efficient processing and analysis of sweat samples. The Reynolds number Re (Reynolds Number, Re) is an important parameter for designing the flow resistance. The Reynolds number can be used to judge the flow pattern and flow state of the fluid in the microfluidic chip channel. The flow pattern can be judged according to the Reynolds number: laminar flow (Re < 2000), transitional flow (2000 < Re < 4000), and turbulent flow (Re > 4000). Among them, laminar flow is relatively stable and is more suitable for applications that require precise control and uniform mixing; while turbulent flow has a higher mixing effect, but it is easy to produce irregular velocity and pressure distributions. By controlling the Reynolds number, the flow pattern suitable for specific applications can be selected.

[0077] ;

[0078] Among them, ρ is the density of sweat, v is the characteristic velocity of sweat, μ is the viscosity of sweat, and D is the characteristic length of the microfluidic chip; determine the characteristic length D, design the flow resistance, and calculate the corresponding value of Re to make the flow pattern of sweat with flow resistance be laminar flow.

[0079] The sample discharge port is located at the outlet of the microfluidic chip channel for multi-channel sweat collection and is used to collect the processed sweat samples.

[0080] Based on the theory of fluid mechanics, the microfluidic channels, flow resistance and other structural units of the microfluidic chip are designed to enable the microfluidic chip to collect human sweat with high quality.

[0081] As Figure 1 shown, the microcontroller unit MCU is used for signal connection and logical operation. The sensors include a glucose sensor, a lactate sensor, and a pH sensor; the signal generator is used to output the excitation signal required for the reaction to the potentiostat circuit. The potentiostat circuit is connected to the sensors to maintain the normal operation of the three-electrode system and collect the current on the working electrode, and convert it into a voltage signal that is easy to measure; the ADC channel of the microcontroller unit MCU has qualified stability, but the accuracy is not enough to meet the needs. Therefore, an ADS1298 chip with 4-bit high precision is used for data acquisition. The signals output by the three sensors are sent to the gain amplifier through the multiplexer and the detection port, and then the internal data is calibrated through the modulator, and then converted into a 24-bit digital signal through A / D and transmitted to the microcontroller unit MCU through the SPI interface communication. At the same time, during this process, a stable positive reference input voltage is provided by an external wide linear voltage regulator chip to ensure high stability during data measurement.

[0082] In this embodiment, the ADS1298 chip is a 24-bit analog-to-digital converter that provides complete high-resolution measurements and has low power consumption, with a power consumption of 0.75mW per channel in normal operating mode.

[0083] In a practical application embodiment of the present invention, the effect of the device was demonstrated through a 10-minute sweat detection experiment. The subject was a healthy male (20 years old), the ambient temperature was 25°C, the ambient atmospheric pressure was 101.3 kPa, and the device was worn on the forearm.

[0084] Temperature control: Set the target temperature Ts = 40°C (suitable for promoting sweat secretion), the temperature sensor detects the initial temperature Tm = 25°C, and the error e(s) = 40 - 25 = 15°C. Initialize PID parameters: K P =0.5, K i =0.1, K d =0.05, T i =0.2, T d =0.05. By adjusting the duty cycle of the power controller of the heating resistor wire to 60% using the PID algorithm, the temperature stabilized at 40±0.5°C after 10 seconds, and the sweat secretion rate reached 0.1 μL / min / cm².

[0085] Pressure control: The ambient atmospheric pressure PA = 101.3 kPa is detected, and the target internal pressure P is set. Z =90 kPa (pressure difference 11.3 kPa, ensuring adsorption). Initial internal pressure Ph = 101.3 kPa, error e(t) = 90 - 101.3 = -11.3 kPa, initialize PID parameters: K P =0.4, K i =0.08, K d =0.03, and after 5 seconds the internal pressure stabilizes at 90±0.2 kPa, and the device is firmly attached to the skin.

[0086] Microfluidic chips:

[0087] Inlet: Eight circular inlets with a diameter of 500 μm are used, covering an area of ​​approximately 1.57 mm², with a sweat flow rate of 0.05 μL / s. The microfluidic channel width is 150 μm. The calculated Reynolds number Re is: ρ = 1000 kg / m³, v = 4.5 μm / s, μ = 1 mPa·s, D = 150 μm, Re ≈ 0.000675 (laminar flow, steady flow).

[0088] Storage tank: Dimensions 2 mm × 2 mm × 0.5 mm, capacity 2 μL, aligned with the sensor with a deviation of <50 μm. Sweat remains in the storage tank for approximately 20 seconds to ensure sufficient reaction.

[0089] Flow resistance: The design flow resistance controls the flow rate to 0.05 μL / s and the pressure drop to approximately 0.1 Pa, meeting the low pressure drop requirement.

[0090] Sensors: A glucose sensor, a lactic acid sensor, and a pH sensor are used. The three-electrode system (RE, CE, WE) is driven by a constant potential circuit, and a signal generator outputs a 1 kHz excitation signal to the constant potential circuit.

[0091] Test results: Glucose concentration 0.1 mM (normal range 0.02-0.2 mM), lactate concentration 1.5 mM (normal range 0.5-2.2 mM), pH=6.5 (normal range 4.5-7.5).

[0092] Data processing: The ADS1298 chip (24-bit ADC) converts the voltage signal with a gain of 6 and a sampling rate of 1kHz. The signal undergoes secondary hardware filtering, resulting in a noise level of <0.1μV. The data is transmitted to the microcontroller unit (MCU) via SPI, with a post-processing error of <±2%.

[0093] Experimental results show that the device stably collects sweat within 10 minutes, with a biomarker detection accuracy of 98%, meeting the needs of long-term monitoring. Heating and adsorption control ensure sweat secretion under special conditions (such as low temperature 25°C), the microfluidic chip achieves efficient collection, and the glucose, lactic acid, and pH sensors provide high-precision detection, verifying that the device achieves satisfactory performance.

[0094] This invention also discloses a method for collecting and detecting sweat, using the aforementioned sweat collection and detection device, the method comprising:

[0095] Set the air pressure inside the shell to allow it to adhere to the skin surface;

[0096] Set the temperature inside the casing to promote sweat gland secretion;

[0097] Using a microcontroller unit (MCU), the system acquires set parameters from the sweat collected by the microfluidic chip and detected by sensors.

[0098] The embodiments of the present invention have been described above. However, these embodiments are merely illustrative and not intended to limit the scope of the invention. Although various embodiments have been described above, this does not mean that the measures in the various embodiments cannot be used advantageously in combination. The scope of the invention is defined by the appended claims and their equivalents. Without departing from the scope of the invention, various substitutions and modifications can be made by those skilled in the art, and all such substitutions and modifications should fall within the scope of the invention.

Claims

1. A sweat collection and detection device, characterized in that, include: A shell capable of adsorbing onto the skin surface; the shell contains a microcontroller unit (MCU), a pressure module, a heating module, a microfluidic chip, and sensors. The pressure module is connected to the microcontroller unit (MCU), and the pressure module is used to adjust the pressure difference between the inside and outside of the housing so that the housing can adhere to or leave the skin surface. The heating module is connected to the microcontroller unit (MCU), and the heating module is used to increase the temperature inside the housing to generate sweat on the skin surface. The microfluidic chip is in contact with the skin surface and is used to collect sweat generated on the skin surface; The sensor is connected to the microcontroller unit (MCU) and is used to detect a set index in the sweat collected by the microfluidic chip.

2. The sweat collection and detection device according to claim 1, characterized in that, The pressure module includes a pressure sensor and an air pump. The pressure sensor is used to collect the internal air pressure of the housing. The microcontroller unit (MCU) controls the start and stop of the air pump based on a pre-determined comparison between the external air pressure and the internal air pressure. The air pump can expel the air from inside the housing.

3. The sweat collection and detection device according to claim 1, characterized in that, The heating module includes a temperature sensor and a heating resistance wire; the heating resistance wire and the temperature sensor are respectively connected to the microcontroller unit (MCU); the temperature sensor is used to collect the internal temperature of the housing, the heating resistance wire is used to heat the internal space of the housing, and the MCU controls the operating current of the heating resistance wire based on the comparison result of the internal temperature and a set threshold.

4. The sweat collection and detection device according to claim 1, characterized in that, The sensor is a glucose sensor.

5. The sweat collection and detection device according to claim 1, characterized in that, The sensor is a lactic acid sensor.

6. The sweat collection and detection device according to claim 1, characterized in that, The sensor is a pH sensor.

7. The sweat collection and detection device according to claim 1, characterized in that, The device further includes: a signal generator; the signal generator outputs an excitation signal to an auxiliary port of a constant potential circuit, the constant potential circuit being connected to the sensor.

8. The sweat collection and detection device according to claim 1, characterized in that, The microfluidic chip is a polydimethylsiloxane (PDMS) microfluidic chip.

9. The sweat collection and detection device according to claim 3, characterized in that, The microcontroller unit (MCU) controls the operating current of the heating resistor wire via a power controller.

10. A method for collecting and detecting sweat, characterized in that: Using the sweat collection and detection device as described in any one of claims 1 to 9, the method comprises: The air pressure inside the housing is set to allow the housing to adhere to the skin surface; The temperature inside the housing is set to promote sweat gland secretion. Using the microcontroller unit (MCU), the set parameters in the sweat collected by the microfluidic chip and detected by the sensor are obtained.

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