Novel angelica sinensis anti-aging tablet candy formula

Abstract

The invention belongs to the technical field of health food, and discloses a novel angelica sinensis anti-aging tablet candy formula, which comprises the following components by weight: 15-25% of angelica sinensis extract powder; 10-20% of cordyceps militaris extract powder; and 0.5-2% of spermidine. Through scientific compatibility of core components such as the angelica sinensis extract powder, the cordyceps militaris extract powder and the spermidine, a multilayer anti-aging network of oxidation resistance, autophagy activation and immunoregulation is constructed; ferulic acid in angelica sinensis and cordyceps militaris polysaccharide synergistically scavenge free radicals, spermidine activates a cell autophagy pathway, astaxanthin and curcumin form a water-oil two-phase antioxidant system, and the comprehensive anti-aging effect is remarkably improved; compared with traditional single-component tabletted candies, the formula has the advantages that through the synergistic effect of multiple components, the skin elasticity can be improved, the cell aging can be delayed, the nerve protection function can be enhanced, and the full-dimensional anti-aging target can be achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of health-care foods, and in particular relates to a novel formula of angelica sinensis anti-aging compressed candy. Background Art

[0002] Angelica Anti-Aging Candy is a health food made with the traditional Chinese medicinal herb Angelica sinensis as its primary ingredient, combined with other ingredients that may have antioxidant and tonic properties. Its promotional claims often revolve around concepts like "anti-aging" and "regulating Qi and blood."

[0003] Existing anti-aging compressed candies often use a single active ingredient (such as collagen or vitamin E), resulting in a single mechanism of action and insufficient synergistic effects. While the combination of angelica sinensis, Cordyceps militaris, and spermidine has some anti-aging effects, it still suffers from limited antioxidant capacity and low absorption rate. Therefore, improvements are needed. Summary of the Invention

[0004] The purpose of the present invention is to provide a novel formula of Angelica sinensis anti-aging tablet candy to solve the problems raised in the above background technology.

[0005] In order to achieve the above object, the present invention provides the following technical solution: a novel Angelica anti-aging tablet candy formula, comprising the following ingredients and weight percentages: Angelica extract powder 15-25%; Cordyceps militaris extract powder 10~20%; Spermidine 0.5~2%; Astaxanthin 0.1~0.5%; Sodium hyaluronate 0.5~1.5%; Curcumin 0.2~1%; Glycyrrhizin 1~3%; β-cyclodextrin 20-30%; Magnesium stearate 0.5~1%; Other auxiliary materials remainder; Among them, the ferulic acid content in the angelica extract powder is ≥1 mg / g; the cordycepin content in the Cordyceps militaris extract powder is ≥0.3 mg / g, and the polysaccharide is ≥30 mg / g; the astaxanthin is an extract of Haematococcus pluvialis with a purity of ≥5%; the curcumin is encapsulated by β-cyclodextrin, the molecular weight of the sodium hyaluronate is 800~1500 kDa, and other excipients include sweeteners, disintegrants, etc.

[0006] Preferably, the following steps are included: A1. Prepare raw materials: Accurately weigh the raw materials according to the formula ratio to ensure that they are free of lumps and contamination. Use an electronic precision balance and a vibration screening machine for pre-processing to lay the foundation for the subsequent mixing process; A2. Raw material pretreatment: Angelica sinensis extract powder, Cordyceps militaris extract powder, and β-cyclodextrin are sieved through an 80-mesh sieve to prevent agglomeration and affect uniformity. Curcumin and β-cyclodextrin are premixed in a ratio of 1:5 and then placed in a high-speed shear emulsifier (3000 rpm, 10 minutes) for embedding. A3. Mixing process: First, place the angelica extract powder, Cordyceps militaris extract powder, and the encapsulated curcumin mixture into a three-dimensional motion mixer and mix for 15 minutes. Then, add spermidine, astaxanthin, sodium hyaluronate, and glycyrrhizin in sequence and mix for 10 minutes. Finally, add β-cyclodextrin, magnesium stearate, and sweetener and mix for 20 minutes to ensure that all ingredients are evenly distributed without stratification or aggregation. A4. Granulation and Drying: Spray the evenly mixed powder into a 5% ethanol solution to form a soft material. Granulate the material using an oscillating granulator (20-mesh screen). Dry the wet granules in a hot air circulation oven (50±5°C) for 2 hours to control the moisture content to ≤5%. After drying, pass the granules through a 30-mesh screen to ensure that the granule fluidity meets the requirements for tableting. A5. Tablet Compression: Add magnesium stearate to the granules after granulation and mix for 5 minutes. Use a rotary tablet press to adjust the pressure to 5-8 kN, compress 0.3 g / tablet, control the tablet hardness to 50-80 N, and the disintegration time to ≤30 minutes to ensure the tablet shape is intact and the taste is moderate. A6. Packaging and Storage: Immediately after tableting, seal the tablets using an aluminum-plastic blister packaging machine or pack them into PE bottles. Each box contains 10 bottles, covered with a light-proof film, and labeled "Protect from light, seal, and store in a cool and dark place." The finished product should be stored in a cool and dry environment (temperature ≤ 25°C, humidity ≤ 60%).

[0007] Preferably, the spermidine is a wheat germ extract with a purity of ≥98%. During the mixing process, the ambient temperature needs to be controlled at ≤25°C to avoid degradation of the active ingredient.

[0008] Preferably, the astaxanthin addition process needs to be carried out in the dark, and an amber container is used for packaging, and an aluminum-plastic composite light-proof material is used in the packaging process to ensure its antioxidant activity.

[0009] Preferably, after the curcumin is encapsulated with β-cyclodextrin, its water solubility is increased by more than 50%, and its bioavailability is increased by 30-40%.

[0010] Preferably, the sodium hyaluronate is a pharmaceutical grade raw material with a molecular weight of 800-1500 kDa, which can synergistically increase the moisture content of the skin by more than 25% with the angelica extract powder.

[0011] Preferably, during the tableting process, the die system needs to maintain a temperature of 20-25°C and the pressure fluctuation range is controlled within ±0.5kN to ensure that the tablets have a smooth appearance and a weight difference of ≤3%.

[0012] Preferably, the packaging process needs to be carried out in a 100,000-class clean environment, the heat sealing temperature of the aluminum-plastic blister packaging is controlled at 150-180°C, and the sealing strength is ≥3.0N / 15mm.

[0013] The beneficial effects of the present invention are as follows: 1. This invention constructs a multi-level anti-aging network of "antioxidation-autophagy activation-immunomodulation" by scientifically combining core ingredients such as angelica extract powder, Cordyceps militaris extract powder, and spermidine. Ferulic acid in angelica and Cordyceps militaris polysaccharides synergistically scavenge free radicals, spermidine activates the cellular autophagy pathway, and astaxanthin and curcumin form a water-oil dual-phase antioxidant system, significantly enhancing the comprehensive anti-aging effect. Compared with traditional single-ingredient compressed candies, this formula can simultaneously improve skin elasticity, delay cell aging, and enhance neuroprotective function through the synergistic action of multiple ingredients, achieving a full-dimensional anti-aging goal.

[0014] 2. This invention utilizes β-cyclodextrin encapsulation technology to increase the water solubility of curcumin by over 50% and its bioavailability by 30%-40%. Furthermore, by precisely controlling the molecular weight of sodium hyaluronate and spermidine during a low-temperature mixing process, the stability of each active ingredient during processing and storage is ensured. Accelerated testing demonstrated that the encapsulated curcumin retention rate reached 91.2% at 40°C for six months, compared to only 32.5% in the unencapsulated control group. This technology effectively addresses the key issues of active ingredient degradation and insufficient absorption in traditional anti-aging candies, fully unleashing the product's efficacy.

[0015] 3. The present invention ensures stable product quality through strict process parameter design and full light-proof operation. The packaging process in a 100,000-level clean environment ensures that the product seal strength is ≥3.0N / 15mm. Combined with the aluminum-plastic composite light-proof material, the photodegradation rate of astaxanthin is reduced to below 10%. The precise management of the temperature control and pressure fluctuation range of the die system ensures that the tablet weight difference is ≤3% and the hardness is stable at 50-80N, which not only ensures the taste but also is easy to swallow. Compared with anti-aging candies produced by traditional methods, the active ingredient retention rate of this product is greater than 90% within the 30-month shelf life, solving the common problems in the industry such as poor storage stability and large batch differences. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the preparation process of the present invention. DETAILED DESCRIPTION

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0018] Example 1 The embodiment of the present invention provides a novel formula of Angelica sinensis anti-aging tablet candy, which includes the following ingredients and weight percentages: Angelica extract powder 15-25%; Cordyceps militaris extract powder 10~20%; Spermidine 0.5~2%; Astaxanthin 0.1~0.5%; Sodium hyaluronate 0.5~1.5%; Curcumin 0.2~1%; Glycyrrhizin 1~3%; β-cyclodextrin 20-30%; Magnesium stearate 0.5~1%; Other auxiliary materials remainder; Among them, the ferulic acid content in the angelica extract powder is ≥1 mg / g; the cordycepin content in the Cordyceps militaris extract powder is ≥0.3 mg / g, and the polysaccharide is ≥30 mg / g; the astaxanthin is an extract of Haematococcus pluvialis with a purity of ≥5%; the curcumin is encapsulated by β-cyclodextrin, the molecular weight of the sodium hyaluronate is 800~1500 kDa, and other excipients include sweeteners, disintegrants, etc.

[0019] By scientifically combining a variety of natural active ingredients, a multi-target synergistic anti-aging system has been constructed; advanced encapsulation technology has been used to significantly improve the bioavailability of active ingredients, and the free radical scavenging ability has been greatly enhanced through a unique water-oil dual-phase antioxidant system. A strict photothermal stability control system has been established to ensure product quality. This formula breaks through the limitations of traditional anti-aging products with a single efficacy and achieves a full range of anti-aging effects from skin repair to nerve protection, from anti-oxidation to immune regulation.

[0020] Example 2 The following steps are included: A1. Prepare raw materials: Accurately weigh the raw materials according to the formula ratio to ensure that they are free of lumps and contamination. Use an electronic precision balance and a vibration screening machine for pre-processing to lay the foundation for the subsequent mixing process; A2. Raw material pretreatment: Angelica sinensis extract powder, Cordyceps militaris extract powder, and β-cyclodextrin are sieved through an 80-mesh sieve to prevent agglomeration and affect uniformity. Curcumin and β-cyclodextrin are premixed in a ratio of 1:5 and then placed in a high-speed shear emulsifier (3000 rpm, 10 minutes) for embedding. A3. Mixing process: First, place the angelica extract powder, Cordyceps militaris extract powder, and the encapsulated curcumin mixture into a three-dimensional motion mixer and mix for 15 minutes. Then, add spermidine, astaxanthin, sodium hyaluronate, and glycyrrhizin in sequence and mix for 10 minutes. Finally, add β-cyclodextrin, magnesium stearate, and sweetener and mix for 20 minutes to ensure that all ingredients are evenly distributed without stratification or aggregation. A4. Granulation and Drying: Spray the evenly mixed powder into a 5% ethanol solution to form a soft material. Granulate the material using an oscillating granulator (20-mesh screen). Dry the wet granules in a hot air circulation oven (50±5°C) for 2 hours to control the moisture content to ≤5%. After drying, pass the granules through a 30-mesh screen to ensure that the granule fluidity meets the requirements for tableting. A5. Tablet Compression: Add magnesium stearate to the granules after granulation and mix for 5 minutes. Use a rotary tablet press to adjust the pressure to 5-8 kN, compress 0.3 g / tablet, control the tablet hardness to 50-80 N, and the disintegration time to ≤30 minutes to ensure the tablet shape is intact and the taste is moderate. A6. Packaging and Storage: Immediately after tableting, seal the tablets using an aluminum-plastic blister packaging machine or pack them into PE bottles. Each box contains 10 bottles, covered with a light-proof film, and labeled "Protect from light, seal, and store in a cool and dark place." The finished product should be stored in a cool and dry environment (temperature ≤ 25°C, humidity ≤ 60%).

[0021] Through scientific step-by-step operations, efficient integration and protection of active ingredients are achieved; precise screening and encapsulation technology is used in the raw material pretreatment stage to significantly improve the uniformity and stability of the ingredients; the staged mixing process ensures that the components are fully dispersed to avoid mutual interference of active ingredients; strict temperature and humidity control and light-proof packaging design effectively maintain the biological activity of heat-sensitive ingredients such as spermidine and astaxanthin; the entire process flow is reasonably designed and highly operational, and can stably produce products with uniform quality and precise efficacy.

[0022] Example 3 The spermidine is a wheat germ extract with a purity of ≥98%. During the mixing process, the ambient temperature needs to be controlled at ≤25°C to avoid degradation of the active ingredient.

[0023] The use of spermidine extracted from high-purity wheat germ and a strict low-temperature mixing process ensures that the activity retention rate of this key anti-aging ingredient reaches over 98%. Temperature control not only avoids the degradation of spermidine, but also prevents the destruction of other heat-sensitive ingredients, ensuring the stability of the product and the continuity of its efficacy.

[0024] Example 4 The astaxanthin addition process needs to be carried out in the dark, and an amber container is used for packaging. Aluminum-plastic composite light-proof materials are used in the packaging process to ensure its antioxidant activity.

[0025] The full light-proof operation and the use of special packaging materials have reduced the photodegradation rate of astaxanthin, a powerful antioxidant, to below 10%; the use of amber containers and the dual protection of aluminum-plastic composite light-proof packaging have effectively maintained the integrity of astaxanthin's molecular structure, ensuring its stable antioxidant activity during the shelf life, significantly improving the product's shelf life and actual use effect.

[0026] Example 5 After the curcumin is embedded in β-cyclodextrin, its water solubility is increased by more than 50% and its bioavailability is increased by 30-40%.

[0027] β-cyclodextrin encapsulation technology increases the water solubility of curcumin by more than 50% and its bioavailability by 30-40%, solving the key problem of low oral absorption rate of curcumin. This technology not only improves the stability of curcumin, but also enhances its synergistic effect with other active ingredients, significantly improving the product's anti-inflammatory and antioxidant effects, and providing strong protection for the efficacy of the formula.

[0028] Example 6 The sodium hyaluronate is a pharmaceutical-grade raw material with a molecular weight of 800-1500 kDa, and can synergistically increase the moisture content of the skin by more than 25% with the angelica extract powder.

[0029] The scientific combination of sodium hyaluronate in a specific molecular weight range and angelica extract powder produces a significant synergistic effect. This combination can increase skin moisture content by more than 25%, while improving skin elasticity and reducing the formation of fine lines. This synergistic effect not only enhances the product's anti-aging effect, but also makes it particularly outstanding in improving skin condition.

[0030] Example 7 During the tableting process, the die system needs to maintain a temperature of 20-25°C and a pressure fluctuation range of ±0.5kN to ensure that the tablets have a smooth appearance and a weight difference of ≤3%.

[0031] Precisely controlled tableting process parameters ensure consistent tablet quality. Temperature is maintained at 20-25°C, and pressure fluctuations adhere to strict standards of ±0.5kN. This results in tablets with a smooth, aesthetically pleasing appearance, a weight variance of ≤3%, and a moderate hardness (50-80N), ensuring both a pleasant taste and the stable release of the active ingredients.

[0032] Example 8 The packaging process must be carried out in a 100,000-class clean environment, the heat sealing temperature of the aluminum-plastic blister packaging must be controlled at 150~180°C, and the sealing strength must be ≥3.0N / 15mm.

[0033] The packaging process in a 100,000-class clean environment and precise heat-sealing temperature control (150-180°C) ensure that the product's sealing strength reaches a high standard of ≥3.0N / 15mm. This rigorous packaging process not only effectively isolates oxygen and moisture, but also prevents microbial contamination, allowing the product to have a shelf life of up to 30 months in a cool and dry environment, greatly enhancing the product's commercial value and user experience.

[0034] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0035] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A new type of angelica anti-aging tablet candy formula, characterized in that: It includes the following ingredients and weight percentages: Angelica extract powder 15-25%; Cordyceps militaris extract powder 10~20%; Spermidine 0.5~2%; Astaxanthin 0.1~0.5%; Sodium hyaluronate 0.5~1.5%; Curcumin 0.2~1%; Glycyrrhizin 1~3%; β-cyclodextrin 20-30%; Magnesium stearate 0.5~1%; Other auxiliary materials remainder; Among them, the ferulic acid content in the angelica extract powder is ≥1 mg / g; the cordycepin content in the Cordyceps militaris extract powder is ≥0.3 mg / g, and the polysaccharide is ≥30 mg / g; the astaxanthin is an extract of Haematococcus pluvialis with a purity of ≥5%; the curcumin is encapsulated by β-cyclodextrin, the molecular weight of the sodium hyaluronate is 800~1500 kDa, and other excipients include sweeteners and disintegrants.

2. The novel angelica anti-aging tablet candy formula according to claim 1, characterized in that: The following steps are included: A1. Prepare raw materials: Accurately weigh the raw materials according to the formula ratio to ensure that they are free of lumps and contamination. Use an electronic precision balance and a vibration screening machine for pre-processing to lay the foundation for the subsequent mixing process; A2. Raw material pretreatment: Pass angelica extract powder, Cordyceps militaris extract powder, and β-cyclodextrin through an 80-mesh sieve to prevent agglomeration that affects uniformity. Premix curcumin and β-cyclodextrin at a ratio of 1:5 and place in a high-speed shear emulsifier for encapsulation. A3. Mixing process: First, place the angelica extract powder, Cordyceps militaris extract powder, and the encapsulated curcumin mixture into a three-dimensional motion mixer and mix for 15 minutes. Then, add spermidine, astaxanthin, sodium hyaluronate, and glycyrrhizin in sequence and mix for 10 minutes. Finally, add β-cyclodextrin, magnesium stearate, and sweetener and mix for 20 minutes to ensure that all ingredients are evenly distributed without stratification or aggregation. A4. Granulation and Drying: The uniformly mixed powder is sprayed into a 5% ethanol solution to form a soft material. The granules are granulated using an oscillating granulator. The wet granules are placed in a hot air circulation oven and dried for 2 hours. The moisture content is controlled at ≤5%. After drying, the granules are sieved through a 30-mesh sieve to ensure that the granule fluidity meets the requirements for tableting. A5. Tablet Compression: Add magnesium stearate to the granules after granulation and mix for 5 minutes. Use a rotary tablet press to adjust the pressure to 5-8 kN, compress 0.3 g / tablet, control the tablet hardness to 50-80 N, and the disintegration time to ≤30 minutes to ensure the tablet shape is intact and the taste is moderate. A6. Packaging and storage: After tableting, immediately seal the tablets using an aluminum-plastic blister packaging machine or pack them into PE bottles. Each box contains 10 bottles, covered with light-proof film, and marked "Protect from light, seal, and store in a cool and dark place". The finished product should be stored in a cool and dry environment.

3. The novel angelica anti-aging tablet candy formula according to claim 2, characterized in that: The spermidine is a wheat germ extract with a purity of ≥98%. During the mixing process, the ambient temperature needs to be controlled at ≤25°C to avoid degradation of the active ingredient.

4. The novel angelica anti-aging tablet candy formula according to claim 3, characterized in that: The astaxanthin addition process needs to be carried out in the dark, and an amber container is used for packaging. Aluminum-plastic composite light-proof materials are used in the packaging process to ensure its antioxidant activity.

5. The novel angelica anti-aging tablet candy formula according to claim 4, characterized in that: After the curcumin is embedded in β-cyclodextrin, its water solubility is increased by more than 50% and its bioavailability is increased by 30-40%.

6. The novel angelica anti-aging tablet candy formula according to claim 5, characterized in that: The sodium hyaluronate is a pharmaceutical-grade raw material with a molecular weight of 800-1500 kDa, and can synergistically increase the moisture content of the skin by more than 25% with the angelica extract powder.

7. The novel angelica anti-aging tablet candy formula according to claim 6, characterized in that: During the tableting process, the die system needs to maintain a temperature of 20-25°C and a pressure fluctuation range of ±0.5kN to ensure that the tablets have a smooth appearance and a weight difference of ≤3%.

8. The novel angelica anti-aging tablet candy formula according to claim 7, characterized in that: The packaging process must be carried out in a 100,000-class clean environment, the heat sealing temperature of the aluminum-plastic blister packaging must be controlled at 150~180°C, and the sealing strength must be ≥3.0N / 15mm.

Images