Program control equipment and medical system

Abstract

The embodiment of the invention discloses program control equipment and a medical system. The program control equipment is in communication connection with a stimulator implanted into a target object, and comprises a display interface and a processor, the display interface comprises a display unit for at least displaying a postoperative brain model of a target object, an operation unit for an operation object to execute parameter selection, and a program control unit for delivering a stimulation instruction to the stimulator; wherein the processor is configured to select and generate a target electric field model displayed on the postoperative brain model displayed on the display unit in an overlapping manner based on target stimulation parameters of an operation object on the operation unit, so that the operation object adjusts the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit; and under the condition that the operation object triggers the program control unit, the target stimulation parameter is sent to the stimulator in a soft output mode. According to the technical scheme, the accuracy of the adopted stimulation parameters can be improved.

Description

Technical Field

[0001] The embodiments of the present disclosure relate to the field of electrical stimulation technology, and in particular to a program-controlled device and a medical system. Background Art

[0002] With the rapid development of neuroscience, biomedical engineering and materials science, neuromodulation technology is increasingly used in clinical medicine and basic research, becoming an important means to treat neurological diseases, restore neural function and explore neural mechanisms.

[0003] Deep brain stimulation (DBS) is an invasive neuromodulation technique. It involves implanting stimulating electrodes into specific neural structures in the brain through stereotactic surgery. A neurostimulator is then implanted in the body to connect to the electrodes. This delivers controlled, weak electrical pulses, thereby altering the electrical activity and function of brain neural circuits and networks, ultimately controlling and improving symptoms.

[0004] However, currently the stimulation parameters are generally debugged based on the doctor's experience and the patient's real-time feedback until the parameters with better effects are determined. The process of adjusting the electrical stimulation parameters is time-consuming and requires multiple trials, which increases the patient's discomfort and time cost of treatment. The treatment effect may be limited due to inaccurate positioning or improper parameter selection, which will affect the stimulation experience of electrical stimulation of the target object. Currently, rapid and accurate debugging for patients has become a technical problem that needs to be solved urgently. Summary of the Invention

[0005] The embodiments of the present disclosure provide a program-controlled device and a medical system to improve the accuracy of stimulation parameters used.

[0006] According to one aspect of the present invention, there is provided a program-controlled device communicatively connected to a stimulator implanted in a target subject, the program-controlled device comprising: a display interface and a processor;

[0007] The display interface includes a display unit for displaying at least a postoperative brain model of the target subject, an operation unit for the operator to select parameters, and a program control unit for delivering stimulation instructions to the stimulator; wherein,

[0008] The processor is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating subject on the operating unit, so that the operating subject can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and send the target stimulation parameters to the stimulator in a soft output mode when the operating subject triggers the program-controlled unit.

[0009] According to another aspect of the present invention, a medical system is provided, the system comprising:

[0010] A stimulator, implanted into the body of the target subject;

[0011] at least one implanted electrode, at least a portion of each implanted electrode being implanted in a target nucleus of the brain of the target subject, the implanted electrode being connected to a stimulator and configured to deliver electrical stimulation to the target nucleus;

[0012] The program-controlled device provided in any embodiment of the present invention is communicatively connected to the stimulator.

[0013] The technical solution of the embodiment of the present disclosure is that the program-controlled device can be connected to the stimulator implanted in the body of the target object in communication, and the program-controlled device includes: a display interface and a processor; the display interface includes a display unit that at least displays the postoperative brain model of the target object, an operation unit for the operating object to perform parameter selection, and a program-controlled unit that delivers stimulation instructions to the stimulator; the processor can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating object on the operation unit, so that the operating object can adjust the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit, and when the operating object triggers the program-controlled unit, the target stimulation parameters are sent to the stimulator in a soft output mode to achieve electrical stimulation of the target object. The above technical solution can display the target electric field model generated according to the target stimulation parameters so that the operating object can accurately adjust the target stimulation parameters based on the displayed target electric field model, thereby improving the accuracy of the stimulation parameters adopted.

[0014] It should be understood that the content described in this section is not intended to identify the key or important features of the embodiments of the present invention, nor is it intended to limit the scope of the present invention. Other features of the present invention will become readily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0016] Figure 1 This is a structural block diagram of a program-controlled device provided according to an embodiment of the present disclosure.

[0017] Figure 2 This is a schematic diagram of a display interface in a program-controlled device provided according to an embodiment of the present disclosure.

[0018] Figure 3This is a structural block diagram of another program-controlled device provided according to an embodiment of the present disclosure.

[0019] Figure 4 This is a structural block diagram of another program-controlled device provided according to an embodiment of the present disclosure.

[0020] Figure 5 It is a schematic diagram of a display interface of mode 1 in an optional example in another program-controlled device provided according to an embodiment of the present disclosure.

[0021] Figure 6 It is a schematic diagram of a display interface of mode 2 in an optional example in another program-controlled device provided according to an embodiment of the present disclosure.

[0022] Figure 7 It is a structural block diagram of a medical system provided according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0023] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0024] It should be noted that the terms "first", "second", etc. in the description and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. The situations of "target", "original", etc. are similar and will not be repeated here. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0025] It is understandable that before using the technical solutions disclosed in the various embodiments of this disclosure, the type, scope of use, usage scenarios, etc. of the personal information involved in this disclosure should be informed to the user and the user's authorization should be obtained in an appropriate manner in accordance with relevant laws and regulations.

[0026] Before introducing the embodiments of the present disclosure, the technical fields and related terms of the application of programmable devices, the current programmable device solutions and the reasons for the problem that the accuracy of the stimulation parameters used therein is not high are first exemplified to better understand why the programmable device solution proposed in the embodiments of the present disclosure can improve the accuracy of the stimulation parameters used.

[0027] Implantable medical systems may include implantable neural stimulation systems, implantable cardiac stimulation systems (also known as pacemakers), implantable drug delivery systems (IDDS), and lead switching systems. Implantable neural stimulation systems may be, for example, DBS, implantable cortical nerve stimulation systems (CNS), implantable spinal cord stimulation systems (SCS), implantable sacral nerve stimulation systems (SNS), and / or implantable vagus nerve stimulation systems (VNS). An implantable neural stimulation system includes a stimulator implanted in the body of a target subject (i.e., an implantable neural stimulator) and a programmable device disposed outside the body of the target subject. In other words, the stimulator is a medical device, or in other words, the medical device includes a stimulator. Related neuromodulation technologies mainly involve implanting electrodes (electrodes, for example, in the form of electrode wires) at specific locations (i.e., targets, also known as target nuclei) in the tissues of an organism through stereotactic surgery, delivering electrical stimulation to the targets through the electrodes to regulate the electrical activity and function of the corresponding neural structures and networks.

[0028] DBS can include an implantable pulse generator (IPG), an extension lead, and an electrode lead. The IPG is connected to the electrode lead via the extension lead and can be implanted in the target subject's body, for example, on the target subject's chest or other internal body part. DBS can also include an IPG and a lead body, with the IPG directly connected to the lead body and the IPG implanted in the target subject's head. For example, a groove is cut into the target subject's skull and the IPG is then installed in the groove. In this case, the IPG may not protrude from the outer surface of the skull, or it may partially protrude from the outer surface of the skull. The IPG can respond to programmable instructions sent by a programmable device and, relying on a sealed battery and circuitry, provide controllable electrical stimulation therapy (or electrical stimulation energy) to the target subject's internal tissues. The IPG delivers one or more controllable, specific electrical stimulations to specific areas of the tissue through the lead body. The extension lead, used in conjunction with the IPG, serves as a transmission medium for the electrical stimulation, transmitting the electrical stimulation generated by the IPG to the lead body.

[0029] The electrical stimulation can be delivered in the form of a pulse signal or a non-pulse signal. For example, the electrical stimulation can be delivered as a signal with various waveform shapes, frequencies and amplitudes. Therefore, the electrical stimulation in the form of a non-pulse signal can be a continuous signal, which can have a sinusoidal waveform or other continuous waveform. After receiving the electrical stimulation transmitted by the IPG or the extension wire, the lead body delivers the electrical stimulation to a specific area of ​​the tissue in the body through a plurality of electrode contacts. The stimulator is provided with, for example, one or more lead bodies on one side or two sides, and a plurality of electrode contacts are provided on the lead body. The electrode contacts can be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) on the circumference of the lead body. The electrode contacts can include stimulation electrode contacts and / or collection electrode contacts. The electrode contacts can be in the shape of sheets, rings or dots.

[0030] The stimulated tissue in the body can be the brain tissue of the target subject, and the stimulated site can be a specific site of the brain tissue. The stimulated sites generally vary from target subject to target subject, and the number of stimulation contacts (single source or multiple sources), the use of one or more specific electrical stimulation channels (single channel or multi-channel), and the stimulation parameters (values) also vary. The target subject tissue type for stimulation is not limited and can include deep brain stimulation (DBS), spinal cord stimulation (SCS), sacral nerve stimulation, gastric stimulation, peripheral nerve stimulation, and / or functional electrical stimulation, among others.

[0031] Currently, during the DBS process, the operator directly selects stimulation parameters based on the individual situation of the target object to optimize the stimulation effect. However, this method lacks an intuitive and accurate stimulation parameter feedback mechanism, which may lead to low accuracy of the stimulation parameters used for electrical stimulation, and may further cause the electrical stimulation range for the target object to be too large or too small, thereby affecting the stimulation effect of the target object and even causing side effects.

[0032] To address this, embodiments of the present disclosure can display a target electric field model generated based on target stimulation parameters, allowing the operator to accurately adjust the target stimulation parameters based on the displayed target electric field model, thereby improving the accuracy of the adopted stimulation parameters. This will be explained in detail below.

[0033] Figure 1 This is a structural block diagram of a program-controlled device provided by an embodiment of the present disclosure. This embodiment is applicable to situations where electrical stimulation is performed on a target object.

[0034] See also Figure 1The program-controlled device 110 of the embodiment of the present disclosure is in communication with the stimulator 120 implanted in the body of the target object. The program-controlled device 110 includes: a display interface 1101 and a processor 1102;

[0035] The display interface 1101 includes a display unit 11011 for displaying at least a postoperative brain model of the target subject, an operation unit 11012 for the operator to select parameters, and a program control unit 11013 for delivering stimulation instructions to the stimulator;

[0036] The processor 1102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameter selection of the operating object on the operating unit 11012, so that the operating object can adjust the target stimulation parameters on the operating unit 11012 based on the target electric field model displayed on the display unit 11011, and send the target stimulation parameters to the stimulator 120 in a soft output mode when the operating object triggers the program control unit 11013.

[0037] In the disclosed embodiments, the programmable device 110 may include a doctor-controlled device (i.e., a programmable device 110 used by a doctor) and / or a user-controlled device (i.e., a programmable device used by a patient). In this application, the programmable device may be a doctor-controlled device, and accordingly, the doctor operating the programmable device 110 may be referred to as an operation object. The doctor-controlled device may be, for example, a tablet computer, laptop computer, desktop computer, and / or mobile phone equipped with programmable software.

[0038] In the embodiment of the present disclosure, the programmable device 110 can be communicatively connected with the stimulator 120 implanted in the body of the target object, that is, the programmable device 110 can be used to adjust one or more stimulation parameters of the stimulator 120 (or one or more stimulation parameters of the pulse generator, different stimulation parameters correspond to different electrical stimulations) so that the stimulator 120 delivers electrical stimulation to the implanted electrode according to the adjusted stimulation parameters to electrically stimulate the target object.

[0039] The target object can be understood as an object implanted with the stimulator 120 and requiring electrical stimulation, which may be a patient. Different patients may have different symptoms, and the locations of the implanted electrodes in the patient's body may also be different.

[0040] The display interface 1101 can be understood as an interface with a display function.

[0041] The processor 1102 can be understood as a processor 1102 having processing functions.

[0042] The post-operative brain model may be understood as a model corresponding to the brain of the target subject after surgery in which the implanted electrodes are implanted.

[0043] In the embodiment of the present disclosure, the processor 1102 can read a medical image of the target object, such as magnetic resonance imaging (MRI) or computed tomography (CT) image data of the target object, and convert the medical image into a three-dimensional space coordinate system to obtain coordinate data; automatically identify brain tissue (such as nuclei, cerebrospinal fluid, and other tissues) in the medical image through an image processing algorithm, and determine the location of the brain tissue in the medical image based on the identification result, wherein the brain tissue at least includes a target nucleus associated with the patient's condition, and the target nucleus can be understood as the area of ​​the target object's brain that needs to be electrically stimulated; determine at least one of the coordinates and shape of the brain tissue in the three-dimensional space coordinate system based on the location and coordinate data; and The coordinates and shape of the brain tissue in the three-dimensional spatial coordinate system are used to determine the position data of the brain tissue in the brain, wherein the position of the target nucleus represented by the position data has a certain matching relationship with the position of the implanted electrode in the brain, thereby ensuring that the electrical stimulation can accurately act on the target nucleus; based on the medical image, coordinate data and position data, a postoperative brain model including the target nucleus can be generated. The generation of the postoperative brain model including the target nucleus can also display the target nucleus when the postoperative brain model is subsequently displayed, so that the operating subject can more accurately adjust the target stimulation parameters through the displayed target nucleus and target electric field model.

[0044] It should be understood that the patient's postoperative medical images may include some features of the implanted electrodes. Of course, different cross-sections in the CT images may contain different features. The electrode model of the implanted electrodes (including electrode wires and electrode contacts) in the patient's brain can be simulated based on the electrode features in the medical images, and the electrode model and the patient's brain tissue module can be aligned and fused to obtain the patient's postoperative brain model.

[0045] The display unit 11011 can be understood as a unit that at least displays the postoperative brain model; in addition to displaying the postoperative brain model, the display unit can also display at least one of the target electric field model, the initial electric field model, and the overlap rate display box, etc., so that the operating object can understand more information through the content displayed by the display unit, which is conducive to more accurate adjustment or setting of parameters related to electrical stimulation.

[0046] The operation object can be understood as an object for operating the program-controlled device 110 .

[0047] Parameter selection can be understood as the selection operation of selecting target stimulation parameters.

[0048] The operation unit 11012 can be understood as a unit that can be operated by an operation object.

[0049] The stimulation instruction may be understood as an instruction delivered to the stimulator 120 to cause the stimulator 120 to electrically stimulate the target object.

[0050] The programming unit 11013 can be understood as a unit that delivers stimulation instructions to the stimulator 120.

[0051] The target stimulation parameters can be understood as parameters involved in causing the stimulator 120 to stimulate the target object. The target stimulation parameters may include at least one of the following: an electrode contact combination for delivering electrical stimulation (the electrode contact combination may include at least one electrode contact identifier, such as electrode contact #2 and electrode contact #3) and electrode stimulation parameters; the electrode stimulation parameters may include at least one of the following: frequency (for example, the number of electrical stimulation pulse signals per unit time 1s, in units of Hz), pulse width (the duration of each pulse, in units of μs), amplitude (generally expressed in voltage, i.e., the intensity of each pulse, in units of V), timing (for example, continuous or burst, where burst refers to a discontinuous timing behavior composed of multiple processes), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode, and cyclic stimulation mode), upper and lower control limits of the operating object (the range within which the operating object can be adjusted), and upper and lower control limits of the target object (the range within which the target object can be adjusted autonomously).

[0052] The target electric field model can be understood as an electric field model generated based on the target stimulation parameters; the target electric field model can also be understood as a model corresponding to the spatial distribution of the activated tissue volume (VTA), which represents the range of influence of the electric field generated by the electrical stimulation on the brain tissue under the electrical stimulation corresponding to the target stimulation parameters.

[0053] In an embodiment of the present disclosure, the processor 1102 can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameter selection of the operating object on the operating unit 11012, so that the operating object can adjust the target stimulation parameters on the operating unit 11012 based on the target electric field model displayed on the display unit 11011. The process of generating the target electric field model can be, for example, that the processor 1102 can calculate the spatial distribution of the VTA under electrical stimulation based on the target stimulation parameters and the principle of a physical model (such as an electric field model) (for example, dynamically calculate the spatial distribution based on the position of the implanted electrode in the brain, the target stimulation parameters and the brain structure through the principle of a physical model), and generate a target electric field model based on the spatial distribution (for example, it can be expressed in the form of a three-dimensional VTA range); for another example, it can be that the individualized data of the target object (the individualized data can, for example, include at least one of a medical image of the brain, the three-dimensional coordinates of the target nucleus in a three-dimensional coordinate system, and the position of the implanted electrode in the brain), electrode parameters (the electrode parameters can, for example, include at least one of the model, polarity, size, material and electrode spacing of the implanted electrode), and brain tissue characteristics (at least one of the brain tissue conductivity, dielectric constant and anisotropy characteristics), determine at least one candidate stimulation parameter based on the target stimulation parameters, the individualized data, the electrode parameters and the brain tissue characteristics, and generate a target electric field model that is superimposed and displayed on the postoperative brain model displayed on the display unit 11011.

[0054] In the embodiment of the present disclosure, before the processor 1102 generates the target electric field model, the processor 1102 may obtain the target stimulation parameter selected by the operating subject on the operating unit 11012. It should be noted that the target stimulation parameter may be selected by the operating subject from at least one candidate stimulation parameter displayed on the operating unit 11012. This method of selecting the target stimulation parameter may help the operating subject to efficiently select the target stimulation parameter. Alternatively, the target stimulation parameter may be directly input by the operating subject through the operating unit 11012. This method of selecting the target stimulation parameter may help to obtain the target stimulation parameter that better meets the needs of the operating subject.

[0055] In the embodiment of the present disclosure, after the operating object adjusts the target stimulation parameters on the operating unit 11012 based on the target electric field model displayed on the display unit 11011, the target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 can be updated in real time based on the target stimulation parameters, so that the operating object can adjust the target stimulation parameters on the operating unit 11012 based on the updated target electric field model displayed on the display unit 11011, and repeat the step of updating the target electric field model superimposed on the postoperative brain model displayed on the display unit 11011 based on the target stimulation parameters until the operating object believes that the target stimulation parameters are accurate and no longer adjusts the target stimulation parameters. The above-mentioned process of dynamically adjusting the target electric field model displayed on the display unit 11011 in real time can enable the operating object to timely understand the target electric field model under the current target stimulation parameters, thereby facilitating the adjustment of the target stimulation parameters more accurately.

[0056] In the embodiment of the present disclosure, the display unit 11011 can also display the changes in the target electric field model displayed under different target stimulation parameters (for example, the target stimulation parameters corresponding to before and after adjustment or multiple sets of different target stimulation parameters selected), so as to provide more information for the operating object to adjust the target stimulation parameters.

[0057] In the embodiment of the present disclosure, the selection and / or adjustment of the target stimulation parameters can be performed in the current mode or the voltage mode, so that the voltage or current of the electrical stimulation delivered to the patient can be more accurate through the selection and / or adjustment of the target stimulation parameters.

[0058] Soft Output Mode can be understood as a mode of progressively outputting target stimulation parameters. This is because when delivering electrical stimulation to the patient's brain nuclei, if a higher stimulation intensity is suddenly delivered, it may cause greater discomfort to the patient, which is not conducive to subsequent treatment and the doctor's accurate control of the patient's treatment condition. Through the soft output module, electrical stimulation can be delivered to the patient in a progressive manner, so that the patient can gradually adapt to the intensity of the stimulation, thereby improving the patient's treatment experience.

[0059] In an embodiment of the present disclosure, the processor 1102 may send the target stimulation parameters to the stimulator 120 in a soft output mode when the operation object triggers the program control unit 11013 .

[0060] Exemplarily, the processor 1102 can generate a target electric field model superimposed on the display unit 11011 based on the target stimulation parameters selected by the operating object through the operating unit 11012; the display unit 11011 can display the postoperative brain model and the target electric field model superimposed on the postoperative brain model, so that the operating object can adjust the target stimulation parameters through the operating unit 11012 based on the target electric field model displayed on the display unit 11011 (if the operating object believes that the target stimulation parameters are accurate based on the target electric field model displayed on the display unit 11011, the target stimulation parameters may not be adjusted); the processor 1102 can send the target stimulation parameters to the stimulator 120 in a soft output mode through a stimulation instruction when the operating object triggers the program control unit 11013, so that the stimulator 120 electrically stimulates the target object according to the target stimulation parameters.

[0061] In the embodiment of the present disclosure, the processor 1102 can also be configured to sense the electrophysiological activity of the target object through the stimulator 120 to acquire electrophysiological signals, and adjust the target stimulation parameters according to the electrophysiological activity and electrophysiological signals to achieve closed-loop control (or adaptive adjustment) of the target stimulation parameters.

[0062] The solutions of the embodiments of the present disclosure can be applied to the field of biomedical engineering, and more specifically, to medical fields such as neuromodulation and electrical stimulation therapy.

[0063] The programmable device 110 of the embodiment of the present disclosure can provide the operating object with an efficient, intuitive and friendly display interface 1101, supporting the operating object to freely adjust the target stimulation parameters and view real-time electric field model feedback, so as to help the operating object understand the specific effects of electrical stimulation on brain tissue through the displayed target electric field model, so that the operating object can accurately adjust the target stimulation parameters based on the displayed target electric field model, thereby improving the accuracy of the stimulation parameters used, avoiding excessive or insufficient electrical stimulation, reducing unnecessary side effects, and ensuring that electrical stimulation is safe and effective.

[0064] Optionally, the operating unit 11012 includes at least a stimulation parameter adjustment control, so as to adjust the target stimulation parameter through the stimulation parameter adjustment control, and the adjusted target stimulation parameter includes at least one of frequency, pulse width and amplitude.

[0065] The stimulation parameter adjustment control may be understood as a control for adjusting target stimulation parameters.

[0066] In the embodiment of the present disclosure, the operating unit 11012 includes at least a stimulation parameter adjustment control to adjust the target stimulation parameter through the stimulation parameter adjustment control. The adjusted target stimulation parameter includes at least one of the frequency, pulse width and amplitude of the electrical stimulation, so as to provide an adjustment function for at least one of the frequency, pulse width and amplitude of the electrical stimulation. The adjustment of at least one of the frequency, pulse width and amplitude of the electrical stimulation can effectively adjust the intensity dimension of the electrical stimulation, thereby improving the patient's treatment experience.

[0067] The technical solution of the embodiment of the present disclosure is that the program-controlled device can be connected to the stimulator implanted in the body of the target object in communication, and the program-controlled device includes: a display interface and a processor; the display interface includes a display unit that at least displays the postoperative brain model of the target object, an operation unit for the operating object to perform parameter selection, and a program-controlled unit that delivers stimulation instructions to the stimulator; the processor can generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating object on the operation unit, so that the operating object can adjust the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit, and when the operating object triggers the program-controlled unit, the target stimulation parameters are sent to the stimulator in a soft output mode to achieve electrical stimulation of the target object. The above technical solution can display the target electric field model generated according to the target stimulation parameters so that the operating object can accurately adjust the target stimulation parameters based on the displayed target electric field model, thereby improving the accuracy of the stimulation parameters adopted.

[0068] An optional technical solution, at least one implanted electrode is implanted in the target nucleus of the target object's brain, the stimulator is configured to deliver electrical stimulation to at least part of the implanted electrodes, and the target stimulation parameters include electrode contact combinations and electrode stimulation parameters; the processor is further configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating object on the operating unit, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and when the operating object triggers the program-controlled unit, the electrode contact combination and electrode stimulation parameters are sent to the stimulator in a soft output mode, so that the stimulator delivers electrical stimulation to the implanted electrodes corresponding to the electrode contact combination according to the electrode stimulation parameters, so as to electrically stimulate the target nucleus.

[0069] Among them, the implanted electrode can be understood as an electrode implanted in the target nucleus of the brain of the target object; by implanting the implanted electrode in the brain, electrical stimulation of the target object can be achieved.

[0070] The electrode contact combination can be understood as the combination of contacts on the implanted electrode to which the electrical stimulation is required to be delivered; using different electrode contact combinations, the electric field generated by the electrical stimulation has different influence ranges on the brain tissue. Adjusting the electrode contact combination can effectively adjust the influence range of the electrical stimulation on the brain.

[0071] The electrode stimulation parameters can be understood as the parameters used for electrical stimulation; the electrode stimulation parameters may include, for example, at least one of the current intensity, frequency, pulse width and amplitude of the electrical stimulation.

[0072] In an embodiment of the present disclosure, at least one implanted electrode is implanted at the target nucleus, and the stimulator is configured to deliver electrical stimulation to at least part of the implanted electrodes, and the target stimulation parameters include an electrode contact combination and an electrode stimulation parameter; through a processor, based on the target stimulation parameter selection of the operating object on the operating unit, a target electric field model superimposed on the postoperative brain model displayed on the display unit is generated, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and when the operating object triggers the program-controlled unit, the electrode contact combination and the electrode stimulation parameters are sent to the stimulator in a soft output mode, so that the stimulator delivers electrical stimulation to the implanted electrode corresponding to the electrode contact combination according to the electrode stimulation parameters, so as to electrically stimulate the target nucleus. The above technical solution can more accurately electrically stimulate the target nucleus by using target stimulation parameters including electrode contact combinations and electrode stimulation parameters.

[0073] Based on the above solution, another optional technical solution is that the display unit further includes an overlap rate display frame, and the overlap rate display frame is configured to display the overlap rate between the target electric field model and the target nucleus.

[0074] Among them, see, for example, Figure 2 The coincidence rate display box can be understood as a box that displays the coincidence rate. The box can exist in the form of a pop-up box and does not affect the display of the target nucleus and the target electric field model.

[0075] The coincidence rate can be understood as the coincidence rate between the target electric field model and the target nucleus. The display of the coincidence rate can quickly remind the doctor of the degree of influence of the current stimulation parameters on the target nucleus, which is conducive to the rapid adjustment of the stimulation parameters and the improvement of the efficiency and convenience of programming.

[0076] In the embodiment of the present disclosure, the postoperative brain model may include a target nucleus. When the display unit displays the postoperative brain model, the target nucleus may also be displayed. On this basis, the display unit may also display the overlapping area between the target nucleus and the target electric field model, so as to display the VTA range of the electrical stimulation represented by the target electric field model and its relationship with the target nucleus in an intuitive manner on the display interface, so that the operating subject can clearly understand the size, shape and spatial overlap of the target electric field model with the target nucleus, providing a basis for the operating subject to adjust the target stimulation parameters.

[0077] In the embodiment of the present disclosure, the display unit can also display the coverage area of ​​the target electric field model, the position of the target nucleus, and the relationship between the target nucleus and the target electric field model, etc., so that the operating object can understand more relevant information that can characterize whether the target stimulation parameters are accurate, thereby facilitating more accurate adjustment of the target stimulation parameters.

[0078] In an embodiment of the present disclosure, the processor can also be configured to adjust the content displayed on the display unit by rotating or scaling corresponding to the operation instruction when the operation object triggers an operation instruction such as rotation or scaling for the display unit, so that the operation object can more accurately view the spatial contrast between the target nucleus and the target electric field model in real time, so as to further optimize and adjust the target stimulation parameters.

[0079] In the disclosed embodiment, the display unit may include a coincidence rate display box that displays the coincidence rate between the target electric field model and the target nucleus. The above technical solution can provide a basis for the operator to more accurately adjust the target stimulation parameters by displaying the coincidence rate.

[0080] Another optional technical solution is that the processor is further configured to send the adjusted target stimulation parameters to the stimulator in a soft output mode when the operating object adjusts the target stimulation parameters on the operating unit according to the second object feedback of the target object, so that the stimulator adjusts the electrical stimulation of the target object according to the adjusted target stimulation parameters.

[0081] The second object feedback can be understood as relevant feedback from the target object to itself; the second object feedback may include, for example, physiological indicators and / or subjective feelings of the target object.

[0082] In an embodiment of the present disclosure, when the operating object adjusts the target stimulation parameters on the operating unit according to the feedback from the second object, the processor can send the adjusted target stimulation parameters to the stimulator in a soft output mode, so that the stimulator adjusts the electrical stimulation performed on the target object according to the adjusted target stimulation parameters. The above technical solution can achieve electrical stimulation of the target object that is more in line with the actual situation of the target object, especially when the second object feedback indicates that the target object has discomfort, the target stimulation parameters can be adjusted in time to make the electrical stimulation more in line with the actual situation of the target object and avoid the occurrence of discomfort.

[0083] Figure 3 1 is a block diagram of another program-controlled device provided by an embodiment of the present disclosure. This embodiment is optimized based on the above-mentioned technical solutions. In this embodiment, optionally, the processor is further configured to: before sending the target stimulation parameters to the stimulator in a soft output mode, when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, update the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate; send the initial stimulation parameters to the stimulator in a soft output mode so that the stimulator performs electrical stimulation on the target object according to the initial stimulation parameters; and repeatedly execute the step of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters. The explanations of the terms identical or corresponding to the above-mentioned embodiments are not repeated here.

[0084] For details, see Figure 3 The program-controlled device 210 of this embodiment is in communication with the stimulator 220 implanted in the target object. The program-controlled device includes: a display interface 2101 and a processor 2102;

[0085] The display interface includes a display unit 21011 for displaying at least a postoperative brain model of the target subject, an operation unit 21012 for the operator to select parameters, and a program control unit 21013 for delivering stimulation instructions to the stimulator;

[0086] The processor 2102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 21011 based on the target stimulation parameter selection of the operating subject on the operating unit 21012, so that the operating subject can adjust the target stimulation parameter on the operating unit 21012 based on the target electric field model displayed on the display unit 21011, and send the target stimulation parameter to the stimulator 220 in a soft output mode when the operating subject triggers the program control unit 21013;

[0087] The processor 2102 is further configured to: before sending the target stimulation parameters to the stimulator 220 in a soft output mode, when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, update the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate; send the initial stimulation parameters to the stimulator 220 in a soft output mode so that the stimulator 220 electrically stimulates the target object according to the initial stimulation parameters; and repeat the steps of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator 220 are less than or equal to the target stimulation parameters.

[0088] Among them, the initial stimulation parameters can be understood as the stimulation parameters used by the stimulator to initially electrically stimulate the target object, and the initial stimulation parameters can be understood as the stimulation parameters used by the stimulator to electrically stimulate the target object before the target stimulation parameters are used to electrically stimulate the target object.

[0089] The parameter adjustment rate can be understood as the rate of adjusting the initial stimulation parameters; the parameter adjustment rate can be understood as the rate of change of electrical stimulation in the process of progressively delivering electrical stimulation to the patient. By setting an appropriate parameter adjustment rate, it is possible to achieve progressive delivery of electrical stimulation to the patient at an appropriate speed, so that the patient can gradually adapt to the intensity of the stimulation, thereby improving the patient's treatment experience.

[0090] It should be noted that in the embodiments of the present disclosure, when judging that the initial stimulation parameters are less than or equal to the target stimulation parameters, and adjusting the initial stimulation parameters, the stimulation parameters judged or adjusted may not be all stimulation parameters. Specifically, the stimulation parameters judged or adjusted may be for at least one of the current intensity, frequency, pulse width and amplitude in the initial stimulation parameters, which can be adjusted and compared.

[0091] The technical solution of the embodiment of the present disclosure is that before the target stimulation parameters are sent to the stimulator in a soft output mode, the processor updates the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, and then sends the initial stimulation parameters to the stimulator in a soft output mode so that the stimulator electrically stimulates the target object according to the initial stimulation parameters, and finally repeats the step of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters. The above technical solution can add a mechanism that can gradually adjust the stimulation parameters through the initial stimulation parameters and the parameter adjustment rate, and gradually adjust the initial stimulation parameters used to electrically stimulate the target object until the target stimulation parameters are reached. This can provide the target object with an electrical stimulation adaptation process, and avoid directly stimulating the target object according to the electrical stimulation corresponding to the target stimulation parameters, which may cause discomfort or side effects to the target object.

[0092] An optional technical solution, the processor is further configured to: when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, before updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, generate an initial electric field model superimposed on the postoperative brain model displayed on the display unit based on the initial stimulation parameters; after updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, adjust the initial electric field model displayed on the display unit based on the initial stimulation parameters.

[0093] The initial electric field model can be understood as an electric field model generated based on the initial stimulation parameters.

[0094] In an embodiment of the present disclosure, through a processor, when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, before updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, an initial electric field model superimposed on the postoperative brain model displayed on the display unit is generated based on the initial stimulation parameters, and after updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, the initial electric field model displayed on the display unit is adjusted based on the initial stimulation parameters. A progressively enhanced visualized initial electric field model can be provided to the operating object, so that the operating object can understand the degree of electrical stimulation to the target object.

[0095] In another optional technical solution, the processor is further configured to update the parameter adjustment rate according to an adjustment result obtained when the operating object adjusts the parameter adjustment rate on the operating unit according to the first object feedback of the target object.

[0096] The first object feedback can be understood as relevant feedback from the target object to itself when the target object is electrically stimulated according to the initial stimulation parameters; for example, it can include physiological indicators and / or subjective feelings, etc.

[0097] In the embodiment of the present disclosure, when the operating object adjusts the parameter adjustment rate on the operating unit according to the feedback from the first object, the processor updates the parameter adjustment rate according to the adjustment result, thereby increasing the controllability of the electrical stimulation change process. When the first object feedback indicates that the target object has discomfort, the parameter adjustment rate can be updated in a timely manner to avoid discomfort or side effects caused to the target object by the parameter adjustment rate that does not meet the requirements of the target object.

[0098] Figure 4 This is a structural block diagram of another program-controlled device provided by an embodiment of the present disclosure. This embodiment is optimized based on the above-mentioned technical solutions. In this embodiment, optionally, the processor is further configured to determine at least one similar case that is similar to the target case of the target object from at least one alternative case, and determine the candidate stimulation parameters corresponding to the at least one similar case displayed on the operating unit, so that the operating object can select the target stimulation parameter from the at least one candidate stimulation parameter on the operating unit. The explanations of the terms that are the same as or corresponding to the above-mentioned embodiments are not repeated here.

[0099] For details, see Figure 4 The program-controlled device 310 of this embodiment is in communication with the stimulator 320 implanted in the target object. The program-controlled device includes: a display interface 3101 and a processor 3102;

[0100] The display interface 3101 includes a display unit 31011 for displaying at least a postoperative brain model of the target subject, an operation unit 31012 for the operator to select parameters, and a program control unit 31013 for delivering stimulation instructions to the stimulator.

[0101] The processor 3102 is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit 31011 based on the target stimulation parameter selection by the operating subject on the operating unit 31012, so that the operating subject can adjust the target stimulation parameter on the operating unit 31012 based on the target electric field model displayed on the display unit 31011, and send the target stimulation parameter to the stimulator 320 in a soft output mode when the operating subject triggers the program control unit;

[0102] The processor 3102 is also configured to determine at least one similar case that is similar to the target case of the target object from at least one alternative case, and determine the candidate stimulation parameters corresponding to the at least one similar case displayed on the operation unit 31012, so that the operation object can select the target stimulation parameter from the at least one candidate stimulation parameter on the operation unit 31012.

[0103] The alternative case can be understood as a case that is selected as a similar case; for example, the alternative case can be a case of an alternative subject who has been electrically stimulated.

[0104] The target case can be understood as the case of the target object.

[0105] Similar cases can be understood as alternative cases that are similar to the target case.

[0106] In the disclosed embodiment, the processor 3102 may determine at least one similar case similar to the target case of the target subject from the at least one candidate case. For example, the processor 3102 may retrieve at least one similar case similar to the target case of the target subject from the at least one candidate case in the electrical stimulation parameter database.

[0107] The candidate stimulation parameters can be understood as the stimulation parameters used when the candidate objects corresponding to similar cases are electrically stimulated.

[0108] It can be understood that since the similarity ratio is similar to that of the target case, the candidate stimulation parameters adopted by the similar case are also more likely to be the target stimulation parameters that can be used by the target case. Therefore, the processor 3102 can determine the candidate stimulation parameters corresponding to at least one similar case displayed on the operation unit 31012, so that the operating object can select the target stimulation parameters from at least one candidate stimulation parameter on the operation unit 31012.

[0109] In the embodiment of the present disclosure, it is also possible to determine the case stimulation parameters corresponding to at least one similar case displayed on the operation unit 31012, determine the stimulation parameter range based on the case stimulation parameters corresponding to at least one similar case, and then determine at least one to-be-selected stimulation parameter based on the stimulation parameter range, so that the operation object can select the target stimulation parameter from at least one to-be-selected stimulation parameter on the operation unit 31012. Determining at least one to-be-selected stimulation parameter based on the stimulation parameter range can avoid the situation where the number of case stimulation parameters corresponding to at least one similar case is too small or too discrete, making it difficult to provide more and more comprehensive options that can be selected by the operation object.

[0110] In the embodiment of the present disclosure, the processor 3102 can also determine, for each candidate stimulation parameter, a candidate electric field model displayed on the display unit 31011 based on the candidate stimulation parameter, so that the operating subject can understand the scope of influence of the electrical stimulation on the brain under each candidate stimulation parameter, and the operating subject can select a target stimulation parameter from at least one candidate stimulation parameter on the operating unit 31012 based on the candidate electric field model corresponding to at least one displayed candidate stimulation parameter.

[0111] The technical solution of the disclosed embodiment uses a processor to determine at least one similar case from at least one candidate case that is similar to the target case, and to determine candidate stimulation parameters corresponding to each of the at least one similar case displayed on an operating unit, so that the operator can select a target stimulation parameter from the at least one candidate stimulation parameter on the operating unit. This technical solution can provide at least one optimal candidate stimulation parameter based on the individual differences of the target subject, thereby helping to further improve the accuracy of the adopted stimulation parameters.

[0112] An optional technical solution, the processor is further configured to: determine a similar electric field model of the similar case for each similar case in at least one similar case, superimpose the similar electric field model on the postoperative brain model with a framed reference electric field area, and determine the overlap rate between the similar electric field model superimposed on the postoperative brain model and the reference electric field area; determine a target candidate case from at least one similar case based on the overlap rate corresponding to the at least one similar case, and update at least one similar case based on the target candidate case.

[0113] The similar electric field model can be understood as an electric field model generated based on corresponding candidate stimulation parameters of similar cases.

[0114] The reference electric field region can be understood as the region in the postoperative brain model corresponding to the framed brain region requiring electrical stimulation.

[0115] The overlap ratio can be understood as the overlap ratio between the similar electric field model and the reference electric field region.

[0116] In an embodiment of the present disclosure, the processor can determine a similar electric field model for each similar case. For example, the processor can determine the similar electric field model based on the selected stimulation parameters, individualized data, electrode parameters and brain tissue characteristics corresponding to the similar case; superimpose the similar electric field model on the postoperative brain model of the framed reference electric field area to determine the overlap rate. For example, the similar electric field model can be superimposed on the postoperative brain model of the framed reference electric field area presented in a three-dimensional voxel grid, and the voxel overlap rate between the voxel volume corresponding to the similar electric field model and the voxel volume corresponding to the reference electric field area is calculated.

[0117] The target case to be selected can be understood as a similar case used to update at least one similar case; the number of the target case to be selected can be at least one.

[0118] In an embodiment of the present disclosure, the processor can determine a target candidate case from at least one similar case based on the overlap rate corresponding to at least one similar case. For example, a preset number of similar cases (for example, 3-5) with the highest overlap rate among at least one similar case, or similar cases with an overlap rate greater than a preset overlap rate, can be used as target candidate cases to ensure that the subsequent target electric field model coverage is as accurate as possible, and at least one similar case can be updated based on the target candidate case.

[0119] In the embodiment of the present disclosure, the processor may update at least one similar case according to the target case to be selected. For example, the target case to be selected may be updated to at least one similar case.

[0120] In the embodiment of the present disclosure, the display unit can also display the degree of matching between at least one candidate stimulation parameter and the reference electric field area (which can be determined based on the overlapping rate corresponding to the candidate stimulation parameters), so that the operating object can select the target stimulation parameter from at least one candidate stimulation parameter on the operating unit based on the degree of matching corresponding to the displayed at least one candidate stimulation parameter. The display of the degree of matching can quickly remind the operating object whether each candidate stimulation parameter matches the reference electric field area, thereby facilitating the rapid selection of the target stimulation parameter and improving the efficiency and convenience of programming.

[0121] For example, referring to Table 1 below, the display unit can display at least one candidate stimulation parameter (current intensity in Table 1) and the matching degree corresponding to at least one candidate stimulation parameter, so that the operating object can select the target stimulation parameter that best suits the target object from at least one candidate stimulation parameter on the operating unit based on the above content displayed on the display unit.

[0122] Table 1 Contents displayed by the display unit

[0123] Options Current intensity (mA) Match 1 1.2 92％ 2 2.0 88％ 3 1.8 95％ 4 2.5 85％

[0124] In the embodiment of the present disclosure, a processor determines a similar electric field model for each similar case, superimposes the similar electric field model on a postoperative brain model of a framed reference electric field region, determines an overlap rate, and then determines a target candidate case from at least one similar case based on the overlap rate corresponding to at least one similar case, and updates at least one similar case based on the target candidate case. The above technical solution can determine a similar case that better satisfies the brain region corresponding to the reference electric field region framed by electrical stimulation, thereby helping to provide at least one candidate stimulation parameter for the brain region corresponding to the reference electric field region framed by electrical stimulation, and helping to further improve the accuracy of the stimulation parameters used.

[0125] Based on the above scheme, another optional technical scheme is that the display unit is also configured to display the postoperative brain model before superimposing the similar electric field model onto the postoperative brain model with the determined reference electric field area, so that the operating subject can frame the reference electric field area in the displayed postoperative brain model.

[0126] In the embodiment of the present disclosure, the reference electric field area can be obtained by manually framing the operating subject in the displayed postoperative brain model. For example, the processor can divide the postoperative brain model or medical image into multiple voxels (Voxels) according to the spatial resolution based on individualized data such as the location of the implanted electrode in the brain, and obtain an interactive three-dimensional voxel grid corresponding to the brain displayed on the operating unit, so that the operating subject can frame or adjust the reference electric field area (the reference electric field area usually covers the target nucleus) in the three-dimensional voxel grid displayed on the operating unit through mouse or touch screen operation based on clinical experience, specific stimulation needs or specific neuroanatomical structure. The voxel is a small cube in three-dimensional space, and each voxel represents a tiny volume unit of brain tissue, which can be used for fine electric field calculations. The size and number of voxels are closely related to the resolution of the postoperative brain model or medical image.

[0127] In an embodiment of the present disclosure, a postoperative brain model can be displayed through a display unit before a similar electric field model is superimposed on a postoperative brain model in which a reference electric field area has been determined, so that the operating subject can frame the reference electric field area in the displayed postoperative brain model, thereby providing the operating subject with a function for framing the reference electric field area.

[0128] To better understand the technical solutions of the above disclosed embodiments, an optional example is provided herein. For example, according to target objects with different stimulation requirements and adaptability, the programmable device can provide two modes for the operating object to choose from, including Model 1 and Model 2.

[0129] In the case of operation object selection mode 1, see Figure 5The left part of the user interface (UI) view operation unit in the display interface can be used by the operating subject to select an appropriate electrode contact combination in the target stimulation parameters; the display unit can display a three-dimensional (3D) view of the postoperative brain model. When the operating subject selects the electrode contact combination, the activation effect of the corresponding implanted electrode can be superimposed on the display unit; the right part of the UI view operation unit can be used by the operating subject to adjust the electrode stimulation parameters in the target stimulation parameters. After the electrode contact combination has been selected, the operating subject can manually adjust the electrode stimulation parameters through the operation unit; the display unit can display a target electric field model in a 3D view, which is generated according to the electrode contact combination and the electrode stimulation parameters. When the target stimulation parameters are adjusted, the display unit can update the displayed target electric field model in real time so that the operating subject can immediately see the range of the target electric field model. changes to determine whether the current target stimulation parameters meet the requirements; the UI view programmable control unit can be used to perform electrical stimulation. When the operating object believes that the range of the target electric field model has a high overlap rate with the target nucleus, the operating object can click the "Program Control" button on the programmable control unit to perform electrical stimulation. In this case, the processor automatically sends the current target stimulation parameters and the VTA range represented by the target electric field model to the stimulator, and the stimulator will immediately issue electrical stimulation commands according to the target stimulation parameters and the VTA range. After applying electrical stimulation to the target object, the operating object can observe the target object's reaction and the changes in the displayed target electric field model in real time to determine whether adjustment is needed. If adjustment is required, the operating object can continue to adjust the target stimulation parameters through the operating unit and execute the step of sending the current target stimulation parameters and the VTA range represented by the target electric field model to the stimulator until the best electrical stimulation effect is achieved.

[0130] In the case of operation object selection mode 2, see Figure 6The functions that can be achieved in the display interface of mode 2 are the same as those of mode 1. In addition, after the operating object clicks the "Program" button on the programmable unit, the processor will slowly and gradually increase the current intensity and / or other stimulation parameters in the initial stimulation parameters based on the initial stimulation parameters, and send the increased initial stimulation parameters to the stimulator to ensure that the electrical stimulation intensity is low in the initial stage of electrical stimulation, and the increase is controlled to gradually increase within an adaptation range to ensure that the target object can adapt to the physiological changes brought about by electrical stimulation. The increase rate of the current intensity and / or other stimulation parameters can be adjusted based on the displayed initial electric field model and the first object feedback of the target object, thereby increasing the controllability of the electrical stimulation process to avoid discomfort or side effects caused by sudden changes in stimulation intensity; the display unit can display the initial electric field model of the 3D view, which can be generated by the initial stimulation parameters. The initial electric field model can gradually reach the shape of the target electric field model as the electrical stimulation gradually increases, so that the target object has enough time to adapt to the electrical stimulation process and reduce the risk of discomfort and side effects.

[0131] Figure 7 This is a block diagram of a medical system provided by an embodiment of the present disclosure. This embodiment is applicable to situations where electrical stimulation is performed on a target object.

[0132] See also Figure 7 ,The medical system of the embodiment of the present disclosure includes: a stimulator 410, implanted into the body of a target subject;

[0133] at least one implanted electrode 420 , at least a portion of each implanted electrode 420 being implanted in a target nucleus of the target subject's brain, the implanted electrode 420 being connected to the stimulator 410 and configured to deliver electrical stimulation to the target nucleus;

[0134] The program-controlled device 430 provided in any embodiment of the present disclosure is communicatively connected to the stimulator 410 .

[0135] The technical solution of the embodiments of the present disclosure includes a stimulator implanted in the body of a target subject; at least one implanted electrode, at least a portion of each implanted electrode being implanted in a target nucleus in the brain of the target subject, the implanted electrode being connected to the stimulator and configured to deliver electrical stimulation to the target nucleus; and a programmable device provided in any embodiment of the present disclosure being communicatively connected to the stimulator. The above technical solution improves the accuracy of the stimulation parameters used by the programmable device through the display of a target electric field model generated according to the target stimulation parameters so that the operating subject can accurately adjust the target stimulation parameters based on the displayed target electric field model.

[0136] The above specific embodiments do not limit the scope of protection of the present invention. Those skilled in the art will appreciate that various modifications, combinations, sub-combinations, and substitutions may be made based on design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention are intended to be included within the scope of protection of the present invention.

Claims

1. A program-controlled device, characterized in that: The program-controlled device is communicatively connected to a stimulator implanted in a target subject, and includes: a display interface and a processor; The display interface includes a display unit for displaying at least a postoperative brain model of the target subject, an operation unit for the operator to perform parameter selection, and a program control unit for delivering stimulation instructions to the stimulator; wherein, The processor is configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating object on the operating unit, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and send the target stimulation parameters to the stimulator in a soft output mode when the operating object triggers the programmable unit.

2. The program-controlled device according to claim 1, wherein: The processor is further configured to: Before sending the target stimulation parameter to the stimulator in a soft output mode, if the initial stimulation parameter of the stimulator is less than or equal to the target stimulation parameter, updating the initial stimulation parameter according to the initial stimulation parameter and a parameter adjustment rate; sending the initial stimulation parameters to the stimulator in a soft output mode, so that the stimulator performs electrical stimulation on the target object according to the initial stimulation parameters; Repeating the step of updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate when the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters.

3. The program-controlled device according to claim 2, characterized in that: The processor is further configured to: In a case where the initial stimulation parameters of the stimulator are less than or equal to the target stimulation parameters, before updating the initial stimulation parameters according to the initial stimulation parameters and the parameter adjustment rate, generating an initial electric field model superimposed on the postoperative brain model displayed on the display unit based on the initial stimulation parameters; After the initial stimulation parameters are updated according to the initial stimulation parameters and the parameter adjustment rate, the initial electric field model displayed by the display unit is adjusted based on the initial stimulation parameters.

4. The program-controlled device according to claim 2, characterized in that: The processor is further configured to update the parameter adjustment rate according to an adjustment result obtained when the operating object adjusts the parameter adjustment rate on the operating unit according to the first object feedback of the target object.

5. The program-controlled device according to claim 1, wherein: The operating unit at least includes a stimulation parameter adjustment control, so as to adjust the target stimulation parameter through the stimulation parameter adjustment control, and the adjusted target stimulation parameter includes at least one of frequency, pulse width and amplitude.

6. The program-controlled device according to claim 1, wherein: The processor is further configured to determine at least one similar case that is similar to the target case of the target object from at least one alternative case, and determine the candidate stimulation parameters corresponding to at least one of the similar cases displayed on the operating unit, so that the operating object can select the target stimulation parameter from at least one of the candidate stimulation parameters on the operating unit.

7. The program-controlled device according to claim 6, characterized in that: The processor is further configured to: For each of the at least one similar case, determining a similar electric field model of the similar case, superimposing the similar electric field model onto the postoperative brain model having a framed reference electric field region, and determining an overlap rate between the similar electric field model superimposed onto the postoperative brain model and the reference electric field region; According to the overlapping rates respectively corresponding to at least one of the similar cases, a target case to be selected is determined from at least one of the similar cases, and at least one of the similar cases is updated according to the target case to be selected.

8. The program-controlled device according to claim 7, characterized in that: The display unit is further configured to display the postoperative brain model before superimposing the similar electric field model onto the postoperative brain model in which the reference electric field area has been determined, so that the operator can frame the reference electric field area in the displayed postoperative brain model.

9. The program-controlled device according to claim 1, wherein: At least one implanted electrode is implanted in a target nucleus of the brain of the target subject, the stimulator is configured to deliver electrical stimulation to at least part of the implanted electrode, and the target stimulation parameters include an electrode contact combination and an electrode stimulation parameter; The processor is specifically further configured to generate a target electric field model superimposed on the postoperative brain model displayed on the display unit based on the target stimulation parameter selection of the operating object on the operating unit, so that the operating object can adjust the target stimulation parameters on the operating unit based on the target electric field model displayed on the display unit, and when the operating object triggers the program-controlled unit, send the electrode contact combination and the electrode stimulation parameters to the stimulator in a soft output mode, so that the stimulator delivers electrical stimulation to the implanted electrode corresponding to the electrode contact combination according to the electrode stimulation parameters, so as to electrically stimulate the target nucleus.

10. The program-controlled device according to claim 9, characterized in that: The display unit further includes a coincidence rate display frame configured to display a coincidence rate between the target electric field model and the target nucleus.

11. The program-controlled device according to claim 1, wherein: The processor is further configured to send the adjusted target stimulation parameters to the stimulator in a soft output mode when the operating object adjusts the target stimulation parameters on the operating unit according to the second object feedback of the target object, so that the stimulator adjusts the electrical stimulation of the target object according to the adjusted target stimulation parameters.

12. A medical system, characterized in that: The system comprises: A stimulator, implanted into the body of the target subject; at least one implanted electrode, at least a portion of each of the implanted electrodes being implanted in a target nucleus of the target subject's brain, the implanted electrode being connected to the stimulator and configured to deliver electrical stimulation to the target nucleus; The programmable device according to any one of claims 1 to 11, wherein the programmable device is communicatively connected to the stimulator.

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