Imidazo [1, 2-a] pyridine derivatives

By using imidazo[1,2-a]pyridine derivatives and compositions thereof, the difficulty in controlling plant pathogenic fungi in the prior art, especially infection by Oomycetes, is solved, thereby achieving effective protection of plants.

CN120752236APending Publication Date: 2025-10-03SYNGENTA CROP PROTECITON AG
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Patent Information

Application Number
CN202380085814.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-12-14
Filing Date
2023-12-11
Publication Date
2025-10-03

AI Technical Summary

Technical Problem

It is difficult to effectively control the infection of plant pathogenic fungi, especially Oomycetes, with existing technologies.

Method used

Provided are imidazo[1,2-a]pyridine derivatives of formula (I) and agricultural chemical compositions thereof, which exert fungicidal activity to control the infection of oomycetes by directly applying to plant pathogens or their loci.

Benefits of technology

Effectively reduce the infection and attack of plant pathogenic fungi, especially Oomycetes, and improve the disease resistance of plants.

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Abstract

The present invention relates to compounds of the formula (I) wherein the substituents are as described in claim 1, to processes and methods for preparing compounds of the formula (I), to agrochemical compositions comprising compounds of the formula (I) as described in claim 1, and to methods for preparing the same. To the preparation of these compositions and to the use of these compounds or compositions in agriculture or horticulture for combating, preventing or controlling infestation of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi.
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Description

[0001] The present invention relates to microbicidal imidazo[1,2-a]pyridine derivatives, for example as active ingredients, which have microbicidal activity, in particular fungicidal activity, more particularly activity against Oomycetes. The present invention also relates to the preparation of these imidazo[1,2-a]pyridine derivatives, to intermediates useful in the preparation of these imidazo[1,2-a]pyridine derivatives, to the preparation of these intermediates, to agrochemical compositions comprising at least one of these imidazo[1,2-a]pyridine derivatives, to the preparation of these compositions, and to the use of these imidazo[1,2-a]pyridine derivatives or compositions in agriculture or horticulture for combating, controlling or preventing infection of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi, more particularly Oomycetes.

[0002] It has now been surprisingly found that certain novel imidazo[1,2-a]pyridine derivatives have advantageous fungicidal properties, in particular against Oomycetes.

[0003] Thus, in a first aspect, the present invention provides a compound having formula (I)

[0004]

[0005] wherein Ring W is a 5-8 membered carbocyclic ring, a 5-8 membered heterocyclic ring, a 6-12 membered aromatic ring or a 5-11 membered heteroaromatic ring, wherein each of the 5-8 membered carbocyclic ring, the 5-8 membered heterocyclic ring, the 6-12 membered aromatic ring or the 5-11 membered heteroaromatic ring is optionally replaced by one to four independently selected 1 Substituents substituted;

[0006] A is CH or N;

[0007] A 1 is a carbon atom or a nitrogen atom;

[0008] A 2 is a carbon atom or a nitrogen atom;

[0009] A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A's 3 It's CR 4 ;

[0010] R 1 Selected from halogen, hydroxy, amino, C 1-6Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group;

[0011] R 2a 、R 2b and R 2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy;

[0012] R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and

[0013] R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Alkoxyamino, where C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Each of the alkoxyamino groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen and CN;

[0014] or a salt or N-oxide thereof.

[0015] In a second aspect, the present invention provides an agrochemical composition comprising a compound of formula (I), and more particularly an agrochemical composition comprising a fungicidally effective amount of a compound of formula (I). The composition may further comprise at least one compound selected from the group consisting of additional active ingredients, suitable formulation inerts, carriers, adjuvants, and any mixtures thereof.

[0016] The compounds of formula (I) can be used to control phytopathogenic microorganisms. Thus, in order to control phytopathogens, the compounds of formula (I) according to the invention or compositions comprising the compounds of formula (I) can be applied directly to the phytopathogens, the sites of the phytopathogens, in particular plants susceptible to phytopathogen attack or the propagation material of the plants.

[0017] Thus, in a third aspect, the present invention provides the use of a compound of formula (I), or a composition comprising a compound of formula (I), as described herein, for combating, preventing or controlling plant pathogens.

[0018] In a fourth aspect, the present invention provides a method for combating, preventing or controlling plant pathogens, which method comprises applying a compound of formula (I) as described herein, or a composition comprising a compound of formula (I), to the plant pathogen, to the location of the plant pathogen, in particular to a plant susceptible to attack by the plant pathogen, or to the propagation material of the plant.

[0019] Compounds of formula (I) are particularly effective in combating, preventing or controlling phytopathogenic fungi, in particular Oomycetes. Thus, in a fifth aspect, the present invention provides the use of a compound of formula (I) as described herein, or a composition comprising a compound of formula (I), for controlling phytopathogenic fungi, in particular Oomycetes.

[0020] In a sixth aspect, the present invention provides a method for combating, preventing or controlling plant pathogenic diseases such as plant pathogenic fungi, which comprises applying a compound of formula (I) as described herein, or a composition comprising a compound of formula (I), to the plant pathogenic fungi, or to the location of the plant pathogenic fungi, in particular to plants susceptible to attack by plant pathogenic fungi, in particular Oomycetes, or to the propagation material of the plant.

[0021] Where a group is indicated as being substituted by, for example, alkyl, this includes those groups which are part of other groups, for example alkyl in alkylthio.

[0022] definition:

[0023] - The term "halogen" refers to fluorine (fluoro or F), chlorine (chloro or Cl), bromine (bromo or Br) or iodine (iodo or I), preferably fluorine, chlorine or bromine.

[0024] - As used herein, the term "alkyl" (in isolation or as part of a chemical group) denotes a straight-chain or branched hydrocarbon, preferably having 1 to 6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,2-dimethylpropyl, 1,3-dimethylbutyl, 1,4-dimethylbutyl, 2,3-dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethylbutyl and 2-ethylbutyl. Alkyl groups having 1 to 4 carbon atoms are preferred, for example methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl.

[0025] - The term "alkenyl" (in isolation or as part of a chemical group) denotes a straight-chain or branched hydrocarbon, preferably having 2 to 6 carbon atoms and at least one double bond, for example ethenyl, 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4- -methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl- Alkenyl groups having 2 to 4 carbon atoms are preferred, for example, 2-propenyl, 2-butenyl or 1-methyl-2-propenyl.

[0026] - The term "alkynyl" (in isolation or as part of a chemical group) denotes a straight-chain or branched hydrocarbon, preferably having 2 to 6 carbon atoms and at least one triple bond, for example 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl Alkynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1-ethyl-1-methyl-2-propynyl and 2,5-hexadiynyl. Alkynyl groups having 2 to 4 carbon atoms are preferred, for example, ethynyl, 2-propynyl or 2-butynyl-2-propenyl.

[0027] The term "cycloalkyl" (in isolation or as part of a chemical group) denotes a saturated or partially unsaturated monocyclic, bicyclic or tricyclic hydrocarbon, preferably having 3 to 10 carbon atoms, for example cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl or adamantyl. Cycloalkyl groups having 3, 4, 5, 6 or 7 carbon atoms are preferred, for example cyclopropyl or cyclobutyl.

[0028] -The term "alkoxy" refers to a group having the formula -OR a A group in which R a is an alkyl group as generally defined above. Examples of alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy, isopropoxy, and tert-butoxy.

[0029] -The term "alkylsulfanyl" refers to a group having the formula -SR a A group in which R a is an alkyl group as generally defined above.

[0030] -The term "alkylsulfinyl" refers to a group having the formula -S(O)R a A group in which R a is an alkyl group as generally defined above.

[0031] The term "alkylsulfonyl" refers to a group having the formula -S(O)2R a A group in which R a is an alkyl group as generally defined above.

[0032] - The term "alkoxycarbonyl" refers to a group having the formula R a OC(O)- group, where R a is an alkyl group as generally defined above.

[0033] - The term "alkylaminocarbonyl" refers to a group having the formula R a NHC(O)- group, where R a is an alkyl group as generally defined above.

[0034] "Hydroxy" or "hydroxy" represents an -OH group.

[0035] In the context of the present invention, the terms "combat", "prevent" or "control" and variations thereof mean reducing any undesirable influence, such as pathogenic, more particularly phytopathogenic, in particular infestation or attack of plants or plant-derived products by fungi such as Oomycetes and pathogenic damage to a level that shows improvement.

[0036] As used herein, the term "effective amount" refers to an amount of a compound, salt, or N-oxide thereof, which provides the desired effect upon single or multiple administrations.

[0037] The effective amount is readily determined by one skilled in the art by using known techniques and by observing the results obtained under similar circumstances. In determining the effective amount, many factors are considered, including, but not limited to: the type of plant or derived product to be applied; the pathogen to be controlled and its life cycle; the specific compound to be applied; the type of application; and other relevant circumstances.

[0038] Compounds of formula (I) with at least one basic center can form acid addition salts, for example, with strong inorganic acids (such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, phosphoric acid or hydrohalic acids), strong organic carboxylic acids (such as unsubstituted or, for example, halogen-substituted C1-C4-alkanecarboxylic acids, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, for example oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid, such as hydroxycarboxylic acids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or such as benzoic acid), or organic sulfonic acids (such as unsubstituted or, for example, halogen-substituted C1-C4-alkanesulfonic acids or arylsulfonic acids, for example methanesulfonic acid or p-toluenesulfonic acid). Compounds of formula (I) having at least one acidic group can, for example, form salts with bases, for example mineral salts, such as alkali metal or alkaline earth metal salts, for example sodium, potassium or magnesium salts; or with ammonia or organic amines such as morpholine, piperidine, pyrrolidine, mono-, di- or tri-lower alkylamines, for example ethylamine, diethylamine, triethylamine or dimethylpropylamine, or mono-, di- or trihydroxy-lower alkylamines, for example monoethanolamine, diethanolamine or triethanolamine.

[0039] In each case, the compound with formula (I) according to the present invention is in free form, oxidized form (as N-oxide), covalent hydrated form or salt form (for example, agronomically available or agrochemically acceptable salt form). N-oxide is an oxidized form of a tertiary amine or an oxidized form of a nitrogen-containing heteroaromatic compound. For example, A.Albini and S.Pietra described them in the book "Heterocyclic N-oxides" published by CRC Press, Boca Raton, in 1991. The compound with formula (I) according to the present invention also includes hydrates that can be formed during salt formation.

[0040] The compounds of formula (I) according to the invention also include hydrates which may be formed during salt formation.

[0041] In another embodiment, there is provided a compound according to the present invention having formula (I), wherein the four A 3 It's CR 4 And an A 3 It's N.

[0042] In another embodiment, there is provided a compound according to the present invention having formula (I), wherein

[0043] yes Four A's preferred 3 It's CR 4 .

[0044] In another embodiment, there is provided a compound according to the present invention having formula (I), wherein

[0045] yes Four A's preferred 3 It's CR 4 .

[0046] In another embodiment, there is provided a compound according to the present invention having formula (I), wherein the five A 3 It's CR 4 .

[0047] In another embodiment, there is provided a compound of formula (I) according to the present invention, wherein A 1 is a carbon atom and A 2 It's a nitrogen atom.

[0048] In another embodiment, there is provided a compound of formula (I) according to the present invention, wherein A 1 is a carbon atom and A 2 It is a carbon atom.

[0049] In another embodiment, there is provided a compound of formula (I) according to the present invention, wherein A 1 is a nitrogen atom and A 2 It is a carbon atom.

[0050] In another embodiment, there is provided a compound of formula (I) according to the present invention, wherein A 1 is a nitrogen atom and A 2 It's a nitrogen atom.

[0051] In another embodiment, there is provided a compound according to the present invention having formula (I), wherein ring W

[0052] Selected from:

[0053]

[0054] wherein * represents the point of attachment to the imidazopyridine group in formula (I), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, and

[0055] where R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

[0056] Ring W may be optionally replaced by one to four independently selected R 1 substituted by a substituent.

[0057] More preferably, ring W

[0058] Can be selected from:

[0059]

[0060] wherein * represents the point of attachment to the imidazopyridine group in formula (I), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 As defined in the present invention.

[0061] Ring W may be optionally replaced by one to four independently selected R 1 substituted by a substituent.

[0062] In a specific embodiment, there is provided a compound according to the present invention having formula (I), wherein

[0063] Ring W is a 5-8 membered heterocyclic ring or a 5-11 membered heteroaromatic ring, wherein each of the 5-8 membered heterocyclic ring or the 5-11 membered heteroaromatic ring is optionally substituted by one to four independently selected R 1 Substituents substituted,

[0064] A 1 is a carbon atom or a nitrogen atom;

[0065] A 2 is a carbon atom or a nitrogen atom;

[0066] And more preferably ring W Selected from:

[0067]

[0068] wherein * represents the point of attachment to the imidazopyridine group in formula (I), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, the ring W is optionally substituted by one to four independently selected R as defined in the present invention 1 substituted by a substituent, and wherein R 11 As defined in the present invention; A is N;

[0069] A 3 Independently CR 4 or N, provided there are no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A's 3 It's CR 4 ;

[0070] R 1 Selected from halogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6Alkoxy and CN, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 Each of the alkoxy groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN;

[0071] R 2a 、R 2b and R 2c independently selected from hydrogen, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkoxy and -NHC(O)C 1-6 Alkyl; preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 Alkoxy; and preferably R 2a and R 2c is hydrogen and R 2b Selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy;

[0072] R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6Alkyl and hydroxyl groups, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Each of the alkyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; preferably R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Alkyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Each of the alkyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; and more preferably R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, CN and halogen, where C 1-6 Alkyl and C 1-6 Each of the alkoxy groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and

[0073] R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C1-6 Alkyl, C 1-6 Alkoxy C 1-6 Each of the alkyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen and CN; preferably, R 6 Selected from C 1-6 Alkyl and C 1-6 Alkoxy, where C 1-6 Alkyl and C 1-6 Each of the alkoxy groups is optionally substituted with one to three substituents independently selected from halogen and CN.

[0074] In another embodiment, the compound according to the present invention is selected from:

[0075] Methyl N-[5-[6-[4-(4-fluorophenyl)-5,6-dihydro-1,2,4-oxadiazin-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0076] Methyl N-[5-[8-cyclopropyl-6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0077] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5,6-dihydro-1,2,4-oxadiazin-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0078] Methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0079] Methyl N-[5-[6-[4-(4-fluoro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0080] Methyl N-[5-[6-[4-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0081] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0082] Methyl N-[5-[6-[1-(4-fluoro-3-methoxy-phenyl)imidazol-2-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0083] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0084] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5,6-dihydro-1,2,4-oxadiazin-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0085] Methyl N-[5-[6-[1-(4-fluoro-3-methoxy-phenyl)imidazol-2-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0086] Methyl N-[5-[6-[4-(4-fluoro-3-methyl-phenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0087] Methyl N-[5-[6-[4-(3,4-difluorophenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0088] Methyl N-[5-[6-[4-(4-fluorophenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0089] Methyl N-[5-[8-cyclopropyl-6-[4-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0090] Methyl N-[5-[6-[2-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0091] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-methyl-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0092] Methyl N-[5-[6-[1-(4-fluorophenyl)imidazol-2-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0093] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1,3-dimethyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0094] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1-methyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0095] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)oxazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0096] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1-methyl-imidazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0097] Methyl N-[5-[6-[5-(4-fluorophenyl)-1-methyl-imidazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0098] Methyl N-[5-[6-[4-(4-fluorophenyl)-5,6-dihydro-1,2,4-oxadiazin-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0099] Methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0100] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-methyl-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0101] Methyl N-[5-[6-[2-(4-chloro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0102] Methyl N-[5-[6-[3-(4-fluorophenyl)pyrazin-2-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0103] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0104] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0105] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1-methyl-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0106] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-oxo-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0107] Methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-5-methyl-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0108] Methyl N-[5-[6-[4-(4-fluorophenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0109] Methyl N-[5-[6-[4-(4-fluoro-3-methyl-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0110] Methyl N-[5-[6-[2-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0111] Methyl N-[5-[6-[5-(4-fluorophenyl)-1,3-dimethyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0112] Methyl N-[5-[6-[5-(4-fluorophenyl)-1,2,4-triazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0113] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1H-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0114] Methyl N-[5-[6-[4-(4-fluorophenyl)-1-methyl-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0115] Methyl N-[5-[6-[3-(4-fluorophenyl)-5-methyl-imidazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0116] Methyl N-[5-[6-[4-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0117] Methyl N-[5-[6-[1-(4-fluorophenyl)imidazol-2-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0118] Methyl N-[5-[6-[2-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0119] Methyl N-[5-[6-[4-(4-fluoro-3-methyl-phenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0120] Methyl N-[5-[6-[4-(3,4-difluorophenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0121] Methyl N-[5-[6-[2-(4-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0122] Methyl N-[5-[6-[(2R)-2-(4-fluorophenyl)-5-oxo-pyrrolidin-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0123] Methyl N-[5-[6-[2-(4-fluorophenyl)-5-oxo-pyrrolidin-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0124] Methyl N-[5-[6-[4-(4-fluorophenyl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0125] Methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-5-methyl-imidazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0126] Methyl N-[5-[6-[2-(4-fluorophenyl)-5-methyl-imidazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0127] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-2-methyl-imidazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0128] Methyl N-[5-[6-[5-(4-fluorophenyl)-2-methyl-imidazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0129] Methyl N-[5-[6-[5-(4-fluorophenyl)-1-methyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0130] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-2-methyl-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0131] Methyl N-[5-[6-[4-(4-fluorophenyl)-2-methyl-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0132] Methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)pyrazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0133] Methyl N-[5-[6-[5-(4-fluorophenyl)pyrazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0134] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)oxazol-5-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0135] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)isoxazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0136] Methyl N-[5-[6-[4-(4-fluorophenyl)oxazol-5-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0137] Methyl N-[5-[6-[5-(4-fluorophenyl)oxazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0138] Methyl N-[5-[6-[4-(4-fluorophenyl)isoxazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0139] Methyl N-[5-[6-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0140] Methyl N-[5-[6-[4-(4-fluorophenyl)-5-oxo-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0141] 3-(4-fluorophenyl)-2-[3-[6-(methoxycarbonylamino)-3-pyridinyl]imidazo[1,2-a]pyridin-6-yl]imidazole-4-carboxylic acid ethyl ester;

[0142] Methyl N-[5-[6-[(2R)-2-(4-fluorophenyl)-5-oxo-pyrrolidin-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0143] Methyl N-[5-[6-[5-(4-fluorophenyl)pyrimidin-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0144] Methyl N-[5-[6-[4-(4-fluorophenyl)pyridazin-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0145] Methyl N-[5-[6-[5-cyano-1-(4-fluorophenyl)imidazol-2-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0146] Methyl N-[5-[6-[5-chloro-1-(4-fluorophenyl)imidazol-2-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0147] Methyl N-[5-[6-[5-chloro-2-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0148] Methyl N-[5-[6-[5-cyano-2-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0149] Methyl N-[5-[6-[4-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0150] Methyl N-[5-[6-[2-(4-fluorophenyl)pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0151] Methyl N-[5-[6-[4-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0152] Methyl N-[5-[6-[4-(6-methoxy-3-pyridinyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0153] N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]-2-methoxy-acetamide;

[0154] N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]cyclopropanecarboxamide;

[0155] 1-ethyl-3-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]urea;

[0156] 3-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]-1,1-dimethyl-urea;

[0157] Benzyl N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0158] 1-ethyl-3-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridyl]urea;

[0159] N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]acetamide;

[0160] N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]cyclopropanecarboxamide;

[0161] Methyl N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0162] tert-Butyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0163] tert-Butyl N-[4-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0164] N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]acetamide;

[0165] Methyl N-[5-[6-[5-(3-fluoro-4-methylsulfonyl-phenyl)-1-methyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0166] Methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0167] N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]acetamide;

[0168] tert-Butyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0169] Methyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0170] tert-Butyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate;

[0171] N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]acetamide;

[0172] Benzyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0173] 3-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]-1,1-dimethyl-urea;

[0174] 1-ethyl-3-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]urea;

[0175] N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]cyclopropanecarboxamide;

[0176] N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]phenyl]-2-methoxy-acetamide;

[0177] 1-ethyl-3-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridyl]urea;

[0178] N-[5-[6-[4-(4-Fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]acetamide;

[0179] tert-Butyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0180] N-[5-[6-[4-(4-Fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamic acid tert-butyl ester;

[0181] Methyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0182] N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]acetamide;

[0183] Benzyl N-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]carbamate;

[0184] 3-[4-[6-[4-(4-Fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]-1,1-dimethyl-urea;

[0185] 1-ethyl-3-[4-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]urea;

[0186] N-[4-[6-[4-(4-Fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]cyclopropanecarboxamide;

[0187] N-[4-[6-[4-(4-Fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]phenyl]-2-methoxy-acetamide; and

[0188] 1-Ethyl-3-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridyl]urea.

[0189] The method according to the invention has the advantageous property of protecting plants from attack or infection by pathogens (e.g. phytopathogens), in particular fungi (e.g. Oomycetes), which cause diseases and damage to plants; in particular in the case of plants, the invention makes it possible to control, limit or prevent pathogenic damage to plants, plant parts, plant propagation material and / or growing plants.

[0190] The compounds in Tables 1.1 to 1.162 below illustrate compounds of the present invention.

[0191] Table 1.1 Compounds E1.1 to E1.1078 of formula (I-1) are provided

[0192]

[0193] Where A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b、R 4 As defined in Table Z.

[0194] Tables 1.2 to 1.162 (followed by Table 1.1) each disclose a compound of formula (I-1) wherein A, R 2a 、R 2c 、R 6 and Ring W are specifically defined in Tables 1.2 to 1.162, which reference Table Z (where A 3a 、A 3b 、R 2b 、R 4 is specifically defined).

[0195] Table Z: A 3a 、A 3b 、R 2b and R 4 Definition of substituents

[0196]

[0197]

[0198]

[0199]

[0200]

[0201]

[0202]

[0203]

[0204]

[0205]

[0206]

[0207]

[0208]

[0209]

[0210]

[0211]

[0212]

[0213]

[0214]

[0215]

[0216]

[0217]

[0218]

[0219]

[0220]

[0221]

[0222]

[0223]

[0224]

[0225]

[0226]

[0227]

[0228]

[0229]

[0230]

[0231]

[0232]

[0233]

[0234]

[0235]

[0236]

[0237]

[0238]

[0239]

[0240]

[0241]

[0242]

[0243]

[0244]

[0245]

[0246] Table 1.2 Provided are compounds E2.1 to E2.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0247] Table 1.3 Provided are compounds E3.1 to E3.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0248] Table 1.4 Provided are compounds E4.1 to E4.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0249] Table 1.5 Provided are compounds E5.1 to E5.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0250] Table 1.6 Provided are compounds E6.1 to E6.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0251] Table 1.7 Provided are compounds E7.1 to E7.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0252] Table 1.8 Provided are compounds E8.1 to E8.1078 of formula (I-1) wherein A is CH, R 2aIt's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0253] Table 1.9 Provided are compounds E9.1 to E9.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0254] Table 1.10 Provided are compounds E10.1 to E10.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0255] Table 1.11 Provided are compounds E11.1 to E11.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A3b 、R 2b 、R 4 As defined in Table Z.

[0256] Table 1.12 Provided are compounds E12.1 to E12.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0257] Table 1.13 Provided are compounds E13.1 to E13.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0258] Table 1.14 Provided are compounds E14.1 to E14.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0259] Table 1.15 Provided are compounds 1.15.1 to E15.1078 of formula (I-1) wherein A is CH, R 2a It's H, R2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0260] Table 1.16 Provided are compounds E16.1 to E16.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0261] Table 1.17 Provided are compounds E17.1 to E17.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0262] Table 1.18 Provided are compounds E18.1 to E18.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A3b 、R 2b 、R 4 As defined in Table Z.

[0263] Table 1.19 Provided are compounds E19.1 to E19.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0264] Table 1.20 Provided are compounds E20.1 to E20.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0265] Table 1.21 Provided are compounds E21.1 to E21.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0266] Table 1.22 Provided are compounds E22.1 to E22.1078 of formula (I-1) wherein A is CH, R 2a It's H, R2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0267] Table 1.23 Provided are compounds E23.1 to E23.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0268] Table 1.24 Provided are compounds E24.1 to E24.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0269] Table 1.25 Provided are compounds E25.1 to E25.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A3b 、R 2b 、R 4 As defined in Table Z.

[0270] Table 1.26 Provided are compounds E26.1 to E26.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0271] Table 1.27 Provided are compounds E27.1 to E27.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z. Table 1.28 Provided are compounds E28.1 to E28.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0272] Table 1.29 Provided are compounds E29.1 to E29.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0273] Table 1.30 Provided are compounds E30.1 to 1.30.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0274] Table 1.31 Provided are compounds E31.1 to E31.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0275] Table 1.32 Provided are compounds E32.1 to E32.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R2b 、R 4 As defined in Table Z.

[0276] Table 1.33 Provided are compounds E33.1 to E33.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0277] Table 1.34 Provided are compounds E34.1 to E34.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0278] Table 1.35 Provided are compounds E35.1 to E35.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0279] Table 1.36 Provided are compounds E36.1 to E36.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2cIt's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0280] Table 1.37 Provided are compounds E37.1 to E37.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0281] Table 1.38 Provided are compounds E38.1 to E38.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0282] Table 1.39 Provided are compounds E39.1 to E39.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R2b 、R 4 As defined in Table Z.

[0283] Table 1.40 Provided are compounds E40.1 to E40.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0284] Table 1.41 Provided are compounds E41.1 to E41.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0285] Table 1.42 Provided are compounds E42.1 to E42.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0286] Table 1.43 Provided are compounds E43.1 to E43.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0287] Table 1.44 Provided are compounds E44.1 to E44.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0288] Table 1.45 Provided are compounds E45.1 to E45.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0289] Table 1.46 Provided are compounds E46.1 to E46.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R4 As defined in Table Z.

[0290] Table 1.47 Provided are compounds E47.1 to E47.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0291] Table 1.48 Provided are compounds E48.1 to E48.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0292] Table 1.49 Provided are compounds E49.1 to E49.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0293] Table 1.50 Provided are compounds E50.1 to E50.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0294] Table 1.51 Provided are compounds E51.1 to E51.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0295] Table 1.52 Provided are compounds E52.1 to E52.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0296] Table 1.53 Provided are compounds E53.1 to E53.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R4 As defined in Table Z.

[0297] Table 1.54 Provided are compounds E54.1 to E54.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0298] Table 1.55 Provided are compounds E55.1 to E55.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0299] Table 1.56 Provided are compounds E56.1 to E56.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0300] Table 1.57 Provided are compounds E57.1 to E57.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0301] Table 1.58 Provided are compounds E58.1 to E58.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0302] Table 1.59 Provided are compounds E59.1 to E59.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0303] Table 1.60 Provided are compounds E60.1 to E60.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a、A 3b 、R 2b 、R 4 As defined in Table Z.

[0304] Table 1.61 Provided are compounds E61.1 to E61.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0305] Table 1.62 Provided are compounds E62.1 to E62.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0306] Table 1.63 Provided are compounds E63.1 to E63.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0307] Table 1.64Provided are compounds E64.1 to E64.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0308] Table 1.65 Provided are compounds E65.1 to E65.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0309] Table 1.66 Provided are compounds E66.1 to E66.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0310] Table 1.67 Provided are compounds E67.1 to E67.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0311] Table 1.68 Provided are compounds E68.1 to E68.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0312] Table 1.69 Provided are compounds E69.1 to E69.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0313] Table 1.70 Provided are compounds E70.1 to E70.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4As defined in Table Z.

[0314] Table 1.71 Provided are compounds E71.1 to E71.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0315] Table 1.72 Provided are compounds E72.1 to E72.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0316] Table 1.73 Provided are compounds E73.1 to E73.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0317] Table 1.74 Provided are compounds E74.1 to E74.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0318] Table 1.75 Provided are compounds E75.1 to E75.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0319] Table 1.76 Provided are compounds E76.1 to E76.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0320] Table 1.77 Provided are compounds E77.1 to E77.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a、A 3b 、R 2b 、R 4 As defined in Table Z.

[0321] Table 1.78 Provided are compounds E78.1 to E78.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0322] Table 1.79 Provided are compounds E79.1 to E79.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0323] Table 1.80 Provided are compounds E80.1 to E80.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0324] Table 1.81 Provided are compounds E81.1 to E81.1078 of formula (I-1) wherein A is CH, R2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0325] Table 1.82 Provided are compounds E82.1 to E82.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0326] Table 1.83 Provided are compounds E83.1 to E83.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0327] Table 1.84 Provided are compounds E84.1 to E84.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A3b 、R 2b 、R 4 As defined in Table Z.

[0328] Table 1.85 Provided are compounds E85.1 to E85.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0329] Table 1.86 Provided are compounds E86.1 to E86.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0330] Table 1.87 Provided are compounds E87.1 to E87.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0331] Table 1.88 Provided are compounds E88.1 to E88.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2cIt's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0332] Table 1.89 Provided are compounds E89.1 to E89.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0333] Table 1.90 Provided are compounds E90.1 to E90.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0334] Table 1.91 Provided are compounds E91.1 to E91.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R4 As defined in Table Z.

[0335] Table 1.92 Provided are compounds E92.1 to E92.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0336] Table 1.93 Provided are compounds E93.1 to E93.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0337] Table 1.94 Provided are compounds E94.1 to E94.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0338] Table 1.95 Provided are compounds E95.1 to E95.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0339] Table 1.96 Provided are compounds E96.1 to E96.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0340] Table 1.97 Provided are compounds E97.1 to E97.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0341] Table 1.98 Provided are compounds E98.1 to E98.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0342] Table 1.99 Provided are compounds E99.1 to E99.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0343] Table 1.100 Provided are compounds E100.1 to E100.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0344] Table 1.101 Provided are compounds E101.1 to E101.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0345] Table 1.102 Provided are compounds E102.1 to E102.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0346] Table 1.103 Provided are compounds E103.1 to E103.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0347] Table 1.104 Provided are compounds E104.1 to E104.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0348] Table 1.105 Provided are compounds E105.1 to E105.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0349] Table 1.106 Provided are compounds E106.1 to E106.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0350] Table 1.107 Provided are compounds E107.1 to E107.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0351] Table 1.108 Provided are compounds E108.1 to E108.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0352] Table 1.109 Provided are compounds E109.1 to E109.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0353] Table 1.110 Provided are compounds E110.1 to E110.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0354] Table 1.111 Provided are compounds E111.1 to E111.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0355] Table 1.112 Provided are compounds E112.1 to E112.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0356] Table 1.113 Provided are compounds E113.1 to E113.1078 of formula (I-1), wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0357] Table 1.114 Provided are compounds E114.1 to E114.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0358] Table 1.115 Provided are compounds E115.1 to E115.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0359] Table 1.116 Provided are compounds E116.1 to E116.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0360] Table 1.117 Provided are compounds E117.1 to E117.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0361] Table 1.118 Provided are compounds E118.1 to E118.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0362] Table 1.119 Provided are compounds E119.1 to E119.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0363] Table 1.120 Provided are compounds E120.1 to E120.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0364] Table 1.121 Provided are compounds E121.1 to E121.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0365] Table 1.122 Provided are compounds E122.1 to E122.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0366] Table 1.123 Provided are compounds E123.1 to E123.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0367] Table 1.124 Provided are compounds E124.1 to E124.1078 of formula (I-1), wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0368] Table 1.125 Provided are compounds E125.1 to E125.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0369] Table 1.126 Provided are compounds E126.1 to E126.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0370] Table 1.127 Provided are compounds E127.1 to E127.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0371] Table 1.128 Provided are compounds E128.1 to E128.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0372] Table 1.129 Provided are compounds E129.1 to E129.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0373] Table 1.130 Provided are compounds E130.1 to E130.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0374] Table 1.131 Provided are compounds E131.1 to E131.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0375] Table 1.132 Provided are compounds E132.1 to E132.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0376] Table 1.133 Provided are compounds E133.1 to E133.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 It is OCH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0377] Table 1.134 Provided are compounds E134.1 to E134.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0378] Table 1.135 Provided are compounds E135.1 to E135.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0379] Table 1.136 Provided are compounds E136.1 to E136.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0380] Table 1.137 Provided are compounds E137.1 to E137.1078 of formula (I-1), wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0381] Table 1.138 Provided are compounds E138.1 to E138.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0382] Table 1.139 Provided are compounds E139.1 to E139.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0383] Table 1.140 Provided are compounds E140.1 to E140.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R2b 、R 4 As defined in Table Z.

[0384] Table 1.141 Provided are compounds E141.1 to E141.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0385] Table 1.142 Provided are compounds E142.1 to E142.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0386] Table 1.143 Provided are compounds E143.1 to E143.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0387] Table 1.144 Provided are compounds E144.1 to E144.1078 of formula (I-1) wherein A is N, R2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0388] Table 1.145 Provided are compounds E145.1 to E145.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0389] Table 1.146 provides compounds E146.1 to E146.1078 of formula (I-1), which

[0390] A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0391] Table 1.147 Provided are compounds E147.1 to E147.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0392] Table 1.148 Provided are compounds E148.1 to E148.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0393] Table 1.149 Provided are compounds E149.1 to E149.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0394] Table 1.150 Provided are compounds E150.1 to E150.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4As defined in Table Z.

[0395] Table 1.151 Provided are compounds E151.1 to E151.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0396] Table 1.152 Provided are compounds E152.1 to E152.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0397] Table 1.153 Provided are compounds E153.1 to E153.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0398] Table 1.154 Provided are compounds E154.1 to E154.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0399] Table 1.155 Provided are compounds E155.1 to E155.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0400] Table 1.156 Provided are compounds E156.1 to E156.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0401] Table 1.157 Provided are compounds E157.1 to E157.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0402] Table 1.158 Provided are compounds E158.1 to E158.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0403] Table 1.159 Provided are compounds E159.1 to E159.1078 of formula (I-1) wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0404] Table 1.160 Provided are compounds E160.1 to E160.1078 of formula (I-1), wherein A is N, R 2a It's H, R 2c It's H, R 6 yes Ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The attachment point of the ring formed by the group, A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0405] Table 1.161Provided are compounds E161.1 to E161.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0406] Table 1.162 Provided are compounds E162.1 to E162.1078 of formula (I-1) wherein A is CH, R 2a It's H, R 2c It's H, R 6 It is CH3, ring W yes wherein * represents the point of attachment to the imidazopyridine group in formula (I-1), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the attachment point of the ring, and A 3a 、A 3b 、R 2b 、R 4 As defined in Table Z.

[0407] The compounds according to the invention may have a number of benefits, including, among others, favorable levels of biological activity for protecting plants against diseases caused by fungi or superior properties for use as active ingredients in agrochemicals (e.g., higher biological activity, favorable activity spectrum, increased safety, improved physico-chemical properties, or increased biodegradability). The compounds according to the invention have particularly favorable levels of biological activity for protecting plants against oomycetes such as Phytophthora, Plasmopara and Pythium.

[0408] The compounds of formula (I) according to the present invention can be prepared as shown in the following Schemes 1 to 22, wherein (unless otherwise stated) the definition of each variable is as defined in the present invention.

[0409] The compound of formula (I) can be prepared by mixing a compound of formula (II) (wherein X is Cl, Br or I) with a compound of formula (III) (wherein either R 8 are independently hydrogen, C1-C6 alkyl, or two of R 8(together can form C3-C8 cycloalkyl) in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate, chloro(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water to prepare by Suzuki cross-coupling. This transformation is depicted in Scheme 1.

[0410]

[0411] A compound of formula (IIa) (wherein A 1 is a carbon atom in formula II, wherein X is Cl, Br or I, and wherein X is more preferably Cl) can be prepared by reacting a compound of formula (Va) (wherein X is Cl, Br, I or a triflate group, and wherein X is more preferably Br, I or a triflate group) with a compound of formula (IV) (wherein X is Cl, Br or I, and wherein X is more preferably Cl, and wherein any R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The cycloalkyl radicals (together to form a C3-C8 cycloalkyl) are prepared by reacting in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. This transformation is depicted in Scheme 2.

[0412]

[0413] Compound (wherein X is Cl, Br or I) with formula (Va) can be prepared by reacting a compound and a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, bromine or iodine and optional alkali such as lithium diisopropylamine or butyllithium with formula (VIa). Alternatively, a compound (wherein X is Cl, Br, I or a trifluoromethanesulfonate group) with formula (VIIa) can be prepared by reacting a compound and trifluoromethanesulfonic anhydride and optional alkali such as triethylamine or pyridine, or a halogenating agent such as phosphorus oxychloride, phosphorus oxybromide, or by reacting with phosphorus oxychloride and sodium iodide continuously. These conversions are carried out in a pure solvent or in a suitable solvent such as dichloromethane, toluene or dimethylbenzene. These conversions are depicted in scheme 3.

[0414]

[0415] Compounds of formula (VIa) and compounds of formula (VIIa) are commercially available, or those skilled in the art will know that they can be synthesized by known methods. Some methods for synthesizing such heteroaromatic compounds can be found in the following publications: J.A. Joule and K. Mills (2010), Heterocyclic Chemistry, 5th ed., Wiley-Blackwell; V.J. Ram, A. Sethi, M. Nath, R. Pratap (2019) The Chemistry of Heterocycles Nomenclature and Chemistry of Three to Five Membered Heterocycles, 1st ed., Elsevier; V.J. Ram, A. Sethi, M. Nath, R. Pratap (2019) The Chemistry of Heterocycles Chemistry of Six to Eight Membered N, O, S, P and Se Heterocycles, 1st ed., Elsevier. Furthermore, one skilled in the art will also recognize that compounds of formula (VIa) and compounds of formula (VIIa) can be readily obtained by CC cross-coupling, CN cross-coupling or by direct CH activation.A subset of the extensive literature describing such transformations is cited here: J.-Q. Chen, J.-H. Li, Z.-B. Dong, Adv. Synth Catal. 2020, 362, 3311; F. Bellina, R. Rossi, Adv. Synth Catal. 2010, 1223; E. Kang, HT Kim, JM Joo, Org. Biomol. Chem. 2020, 18, 6192; Q. Yang, Y. Zhao, D. Ma, Org. Process Res. Dev. [Organic Process Research and Development] 2022, 26, 1690; H. Kaddouri, V. Vicente, A. Ouali, F. Ouazzani, M. Taillefer, Angew. Chem. Int. Ed. [German Applied Chemistry International Edition] 2009, 48, 333; JJ Li and GW Gribble (2007) Palladium in Heterocyclic Chemistry [Palladium in Heterocyclic Chemistry], 2nd edition, Elsevier [Elsevier Publishing]; A. de Meijere, S. M. Oestreich (2014) Metal-Catalyzed Cross-Coupling Reactions and More, Volumes 1-3, Wiley-VCH.

[0416] A compound of formula (IV) wherein X is Cl, Br or I, and wherein X is more preferably Cl, and wherein any R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 Together they can form a C3-C8 cycloalkyl) can be prepared by reacting a compound of formula (VIII) with a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide in a suitable solvent such as DMF, acetonitrile, dichloromethane or tetrahydrofuran. This conversion is depicted in Scheme 4.

[0417]

[0418] A compound of formula (VIII) (wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8can form a C3-C8 cycloalkyl) by reacting a compound having formula (IX) (wherein X is Cl, Br or I) with a compound having formula (X) (wherein either R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 Together they can form a C3-C8 cycloalkyl) in the presence of, for example, bis(pinacol)diborane, bis(neopentyl glycolate)diboron or diboric acid, a catalyst such as dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II)dichloromethane adduct or dichlorobis(tricyclohexylphosphine)palladium and optionally a base such as potassium acetate, in a suitable solvent such as DMF, acetonitrile, toluene, dioxane or tetrahydrofuran to prepare. Alternatively, a compound of formula (VIII) wherein either R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 can form a C3-C8 cycloalkyl) by reacting a compound having formula (IX) (wherein X is Cl, Br or I) with a compound having formula (XI) (wherein either R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The alkyl radicals (together to form a C3-C8 cycloalkyl) are prepared by reacting, for example, trimethyl borate, triisopropyl borate, isopropoxy 4,4,5,5-tetramethyl-1,3,2-dioxaborolane or 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and a metal halogen exchange reagent such as butyl lithium or ethyl magnesium bromide in a suitable solvent such as tetrahydrofuran, diethyl ether or dioxane. These transformations are depicted in Scheme 5.

[0419]

[0420] Compounds of formula (IX) are commercially available or alternatively can be prepared by reacting a compound of formula (XII) (wherein X is Cl, Br or I) and a compound of formula (XIII) (wherein X is Cl, Br or I) or its corresponding acetal of formula (XIV) (wherein X is Cl, Br or I and either R 10 are independently C1-C6 alkyl, or two of R 10 The reaction can be prepared by reacting the alkyl group (together to form a C3-C8 cycloalkyl) in a solvent such as water, ethanol, acetone or acetonitrile. In some cases, the result of the reaction can be improved by using a base such as sodium bicarbonate or potassium carbonate or by using an acid such as p-toluenesulfonic acid or hydrogen bromide. This conversion is depicted in Scheme 6.

[0421]

[0422] Compounds of formula (XII) wherein X is Cl, Br or I are prepared by known methods or are commercially available.

[0423] Alternatively, compounds of formula (II) (wherein X is Cl, Br or I, and wherein X is more preferably Cl) can be prepared by reacting a compound of formula (XV) with a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide in a suitable solvent such as DMF, acetonitrile, dichloromethane or tetrahydrofuran. This conversion is depicted in Scheme 7.

[0424]

[0425] A compound of formula (XVa) wherein A 1 is a carbon atom in formula (XV)) can be prepared by reacting a compound of formula (Va) (wherein X is Cl, Br, I or a triflate group) with a compound of formula (VIII) (wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The cycloalkyl radicals (together to form a C3-C8 cycloalkyl) are prepared by reacting in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. This transformation is depicted in Scheme 8.

[0426]

[0427] Alternatively, a compound of formula (Ia) wherein A 1 is a carbon atom in formula (I), described herein as compound (Ia)) can be obtained by a compound having formula (XVI) wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The cycloalkyl radicals (together to form a C3-C8 cycloalkyl) and compounds of formula (Va) (wherein X is Cl, Br, I or a triflate group) are prepared by Suzuki cross-coupling in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. This transformation is depicted in Scheme 9.

[0428]

[0429] A compound of formula (XVI) (wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 can form a C3-C8 cycloalkyl) by reacting a compound having formula (XVII) (wherein X is Cl, Br or I) with a compound having formula (X) (wherein any R 8 are independently hydrogen, C1-C6 alkyl or two of R 8

[0066] The present invention relates to a cycloalkyl radical (together to form a C3-C8 cycloalkyl) in the presence of, for example, bis(pinacol)diborane, bis(neopentyl glycolate)diboron or diboronic acid, a catalyst such as dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II)dichloromethane adduct or dichlorobis(tricyclohexylphosphine)palladium and optionally a base such as potassium acetate in a suitable solvent such as DMF, acetonitrile, toluene, dioxane or tetrahydrofuran. This transformation is depicted in Scheme 10.

[0430]

[0431] Compounds of formula (XVII) (wherein X is Cl, Br or I) can be prepared by reacting compounds of formula (III) (wherein any of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The compounds of formula (XVIII) wherein X is independently Cl, Br or I are prepared by Suzuki cross-coupling in the presence of a base such as CsCO, KCO or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. It is well understood by those skilled in the art that in order to obtain compounds of formula (XVII), the halogen X from the imidazole ring of the imidazopyridine bicyclic system should have the same or higher reactivity as the halogen X from the pyridine ring of the imidazopyridine bicyclic system. It will be appreciated by those skilled in the art that halogen reactivity increases from chlorine to bromine to iodine. This transformation is depicted in Scheme 11.

[0432]

[0433] Compounds of formula (XVIII) (wherein X is independently Cl, Br or I) can be prepared by reacting compounds of formula (IX) (wherein X is Cl, Br or I) with a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide in a suitable solvent such as DMF, acetonitrile, dichloromethane or tetrahydrofuran. This transformation is depicted in Scheme 12.

[0434]

[0435] Alternatively, a compound of formula (IIa) wherein A 1 is a carbon atom in formula (II), wherein X is Cl, Br or I, and wherein X is more preferably Cl) can be prepared by combining a compound of formula (XVIII) wherein X is independently Cl, Br or I with a compound of formula (XIXa) wherein any R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The alkyl group (together to form a C3-C8 cycloalkyl) is prepared by reacting in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. This transformation is depicted in Scheme 13.

[0436]

[0437] A compound of formula (IIb) wherein A 2 is a carbon atom in formula (II), wherein X is Cl, Br or I, and wherein X is more preferably Cl) can be obtained by combining a compound of formula (XXb) wherein X is independently Cl, Br or I with a compound of formula (XXI) wherein any R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The alkyl radicals (together to form a C3-C8 cycloalkyl) are prepared by reacting in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. This transformation is depicted in Scheme 14.

[0438]

[0439] Compounds of formula (XXI) are either commercially available or can be prepared by one skilled in the art using well-described procedures.

[0440] Compounds of formula (XXb) (wherein X is independently Cl, Br or I) can be prepared by reacting compounds of formula (XXIIb) (wherein X is Cl, Br or I) with a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide in a suitable solvent such as DMF, acetonitrile, dichloromethane or tetrahydrofuran. This conversion is depicted in Scheme 15.

[0441]

[0442] A compound of formula (XXIId) (wherein A 1 and A 2 is a carbon atom in formula (XXII), and wherein X is Cl, Br or I) can be obtained by a compound having formula (XXIIId) wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The compounds of formula (XVIII) wherein X is independently Cl, Br or I are prepared by Suzuki cross-coupling in the presence of a base such as CsCO, KCO or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. It is well understood by those skilled in the art that in order to obtain compounds of formula (XXIId), the halogen X from the pyridine ring of the imidazopyridine bicyclic system should have the same or higher reactivity as the halogen X from the imidazole ring of the imidazopyridine bicyclic system. It will be appreciated by those skilled in the art that halogen reactivity increases from chlorine to bromine to iodine. This transformation is depicted in Scheme 16.

[0443]

[0444] Compounds of formula (XXIIId) are either commercially available or can be prepared by one skilled in the art using well-described procedures.

[0445] A compound of formula (XVc) wherein A 1 is a nitrogen atom in formula (XV)) can be prepared by reacting a compound having formula (IX) (wherein X is Cl, Br or I) with a compound having formula (XXIVc) (wherein A 1(is the nitrogen atom in formula (XXIV)) in the presence of a base such as CsCO, KCO, KHPO or NaOtBu and a suitable palladium catalyst and a suitable palladium catalyst such as XPhos PdG, t-BuXPhos Pd G, MetBuXPhos Pd G, JohnPhos Pd G, RuPhos Pd G, BrettPhos PdG or tBuBrettPhos Pd G in a suitable solvent such as dimethylformamide, dimethylacetamide, dioxane, tetrahydrofuran or toluene to prepare. This transformation is depicted in Scheme 17.

[0446]

[0447] Alternatively, a compound of formula (XVc) wherein A 1 is a nitrogen atom in formula (XV)) can be obtained by a compound having formula (VIII) (wherein any one of R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 The compound of formula (XXIVc) is prepared by reacting a base such as triethylamine, diisopropylethylamine, pyridine, CsCO, KCO, KHPO or NaOtBu and a suitable catalyst such as copper acetate (II), copper carbonate (II), copper hydroxide (II), copper oxide, copper iodide (I) or copper bromide (I) in a suitable solvent such as dimethylformamide, dimethylacetamide, dioxane, acetonitrile, tetrahydrofuran or toluene. In some cases, the reaction result can be improved by adding boric acid or molecular sieves to the reaction mixture. It is understood that these conversions are completed under air because oxygen is required as the final oxidant. In some cases, a copper substance can be used in a stoichiometric amount. This conversion is depicted in Scheme 18.

[0448]

[0449] Those skilled in the art will also recognize that compounds of formula (I) can alternatively be prepared by de novo construction of ring W. This synthetic route has been used and is described in the experimental section of the present invention. Those skilled in the art will appreciate that the synthetic routes described for obtaining these specific compounds can also be used to synthesize similar compounds of formula (I) for the specific compounds, wherein the compounds have the same ring W. Therefore, these routes described in the experimental section should also be considered as general routes for obtaining compounds of formula (I).

[0450] The following compounds of formula (Ia) and (II-a) can be prepared according to the synthetic route used in Example 30. Example 30 describes the preparation of methyl N-[5-[6-[2-(4-fluorophenyl)pyrazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 76). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is pyrazole (compounds of formula (Ia)) and the synthesis of compounds of formula (II) wherein W is pyrazole and X is Cl, Br or I (compounds of formula (II-a)). This method can be generally used to obtain similar compounds of formula (Ia) and formula (II-a).

[0451]

[0452] The following compounds of formula (Ib) and (II-b) can be prepared according to the synthetic route used in Example 29. Example 29 describes the preparation of methyl N-[5-[6-[4-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 75). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is triazole (compounds of formula (Ib)) and the synthesis of compounds of formula (II) wherein W is triazole and X is Cl, Br or I (compounds of formula (II-b)). This method can be generally used to obtain similar compounds of formula (Ib) and formula (II-b).

[0453]

[0454] The following compounds of formula (Ic) and (II-c) can be prepared according to the synthetic routes used in Examples 25, 27 and 28. Example 28 describes the preparation of methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 4), Example 27 describes the preparation of methyl N-[5-[6-[5-cyano-2-(4-fluorophenyl)-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 74), and Example 25 describes the preparation of methyl N-[5-[6-[2-(4-fluoro-3-methoxy-phenyl)-5-methyl-1,2,4-triazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 33). These synthetic routes describe the de novo synthesis of compounds of formula (I) wherein ring W is triazole (compounds of formula (Ic)) and the synthesis of compounds of formula (II) wherein W is triazole and X is Cl, Br or I (compounds of formula (II-c)). These methods can be generally applied to obtain similar compounds of formula (Ic) and formula (II-c).

[0455]

[0456] The following compounds of formula (Id) and (II-d) can be prepared according to the synthetic route used in Example 9. Example 9 describes the preparation of methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5,6-dihydro-1,2,4-oxadiazin-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 10). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is oxadiazine (compounds of formula (Id)) and the synthesis of compounds of formula (II) wherein W is oxadiazine and X is Cl, Br or I (compounds of formula (II-d)). This method can be generally used to obtain similar compounds of formula (Id) and formula (II-d).

[0457]

[0458] The following compounds of formula (Ie) and (II-e) can be prepared according to the synthetic route used in Example 7. Example 7 describes the preparation of methyl N-[5-[6-[4-(4-fluoro-3-methoxy-phenyl)-5-oxo-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 32). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is oxadiazolone (compounds of formula (Ie)) and the synthesis of compounds of formula (II) wherein W is oxadiazolone and X is Cl, Br or I (compounds of formula (II-e)). This method can be generally used to obtain similar compounds of formula (Ie) and formula (II-e).

[0459]

[0460] The following compounds of formula (If) and (II-f) can be prepared according to the synthetic route used in Example 38. Example 38 describes the preparation of methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1,2,4-triazol-1-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 9). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is triazole (compounds of formula (If)) and the synthesis of compounds of formula (II) wherein W is triazole and X is Cl, Br or I (compounds of formula (II-f)). This method can be generally used to obtain similar compounds of formula (If) and formula (II-f).

[0461]

[0462] The following compounds of formula (Ig) and (II-g) can be prepared according to the synthetic route used in Example 35. Example 35 describes the preparation of methyl N-[5-[6-[1-(4-fluoro-3-methoxy-phenyl)imidazol-2-yl]-8-methyl-imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 8). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is imidazole (compounds of formula (Ig)) and the synthesis of compounds of formula (II) wherein W is imidazole and X is Cl, Br or I (compounds of formula (II-g)). This method can be generally used to obtain similar compounds of formula (Ig) and formula (II-g).

[0463]

[0464] The following compounds of formula (Ih) and (II-h) can be prepared according to the synthetic route used in Example 6. Example 6 describes the preparation of methyl N-[5-[6-[5-(4-fluoro-3-methoxy-phenyl)-1-methyl-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-pyridinyl]carbamate (Compound 20). This synthetic route describes the de novo synthesis of compounds of formula (I) wherein ring W is pyrazole (compounds of formula (Ih)) and the synthesis of compounds of formula (II) wherein W is pyrazole and X is Cl, Br or I (compounds of formula (II-h)). This method can be generally used to obtain similar compounds of formula (Ih) and formula (II-h).

[0465]

[0466] In some cases, these de novo syntheses may require the use of compounds of formula (XVI) wherein X is Cl, Br, or I, and R 9 is hydrogen or C1-C6 alkyl) or a compound of formula (XVII) (wherein R 9 is hydrogen or C1-C6 alkyl).

[0467] Compounds of formula (XVI) wherein X is Cl, Br or I and R 9 is hydrogen or C1-C6 alkyl) is commercially available or alternatively can be prepared from a compound of formula (XVII) wherein R 9 is hydrogen or C1-C6 alkyl) and a halogenating agent such as N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide or bromine in a suitable solvent such as dichloromethane, chloroform, tetrahydrofuran or acetonitrile. This transformation is depicted in Scheme 19.

[0468]

[0469] The compound of formula (XVII) (wherein R 9 is hydrogen or C1-C6 alkyl) is commercially available or alternatively can be prepared by reacting a compound of formula (IX) wherein X is Cl, Br or I with carbon monoxide and an alcohol R 9 OH (where R 9 is C1-C6 alkyl or water), in the presence of a catalyst such as PdCl2dppf, and optionally a base such as triethylamine. This transformation is depicted in Scheme 20.

[0470]

[0471] Alternatively, a compound of formula (XVII) wherein R 9is hydrogen or C1-C6 alkyl) can be obtained by a compound having formula (XXV) (wherein R 9 is hydrogen or C1-C6 alkyl) and a compound of formula (XIII) (wherein X is Cl, Br or I) or its corresponding acetal of formula (XIV) (wherein X is Cl, Br or I, and any R 10 are independently C1-C6 alkyl, or two of R 10 The compound of formula (XXV) wherein R 9 is hydrogen or C1-C6 alkyl) are prepared by known methods or are commercially available. This transformation is depicted in Scheme 21.

[0472]

[0473] Alternatively, the compound of formula (I) can be obtained by acylation of a compound of formula (XXVI) using an acylating agent of formula (XXVII) (wherein X is Cl or Br) in the presence of a base such as triethylamine, pyridine or potassium carbonate. The compound of formula (XXVI) can be obtained by reacting a compound of formula (II) (wherein X is Cl, Br or I) and a compound of formula (XXVIII) (wherein either R 8 are independently hydrogen, C1-C6 alkyl, or two of R 8 Together they can form a C3-C8 cycloalkyl) in the presence of a base such as Cs2CO3, K2CO3 or NaOtBu and a suitable palladium catalyst such as tetrakis(triphenylphosphine)palladium, palladium dichloride, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), palladium acetate, chloro(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) or bis(diphenylphosphine)palladium(II) chloride in a suitable solvent such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water to prepare a compound of formula (XXVII) wherein X is Cl or Br and a compound of formula (XXVIII) wherein either R 8 are independently hydrogen, C1-C6 alkyl or two of R 8 Together they can form a C3-C8 cycloalkyl) are commercially available or prepared by known methods. This transformation is depicted in Scheme 22.

[0474]

[0475] When the term "compound / compounds according to the invention" is used this refers to compounds according to the invention.

[0476] Alternatively, the compounds according to the present invention can be obtained by using standard synthesis techniques known to those skilled in the art. Non-exhaustive examples include oxidation reactions, reduction reactions, hydrolysis reactions, coupling reactions, aromatic nucleophilic or electrophilic substitution reactions, nucleophilic substitution reactions, nucleophilic addition reactions, olefination reactions, oxime formation, alkylation and halogenation reactions.

[0477] A compound according to the invention can be converted in a manner known per se into another compound according to the invention by replacing one or more substituents of the starting compound according to the invention with another or further substituent(s) according to the invention in a customary manner.

[0478] Depending on the reaction conditions and starting materials chosen as appropriate in the respective case, it is possible, for example, to replace only one substituent with another substituent according to the invention in one reaction step or to replace several substituents with other substituents according to the invention in one and the same reaction step.

[0479] The salts of the compounds according to the invention can be prepared in a manner known per se. Thus, for example, acid addition salts of the compounds according to the invention are obtained by treatment with a suitable acid or a suitable ion exchanger reagent, and salts with bases are obtained by treatment with a suitable base or with a suitable ion exchanger reagent.

[0480] The salts of the compounds according to the invention can be converted in a customary manner into the free compounds, acid addition salts (for example by treatment with suitable basic compounds or with suitable ion exchange reagents) and salts with bases (for example by treatment with suitable acids or with suitable ion exchange reagents).

[0481] The salts of the compounds according to the invention can be converted into other salts, acid addition salts of the compounds according to the invention in a manner known per se, for example into other acid addition salts, for example by treating salts of inorganic acids (such as hydrochlorides) with suitable metal salts of the acid (such as sodium, barium or silver salts, for example with silver acetate) in a suitable solvent in which the inorganic salt formed (such as silver chloride) is insoluble and therefore precipitates from the reaction mixture.

[0482] Depending on the procedure or reaction conditions, the compounds according to the invention which have salt-forming properties can be obtained in free form or in the form of salts.

[0483] Depending on the number, the absolute and relative configuration of the asymmetric carbon atoms present in the molecule and / or on the configuration of the non-aromatic double bonds present in the molecule, the compounds according to the invention and, where appropriate, their tautomers (in each case in free form or in salt form) may be present in the form of one of the possible stereoisomers or as a mixture of these, for example in the form of pure stereoisomers, such as enantiomers and / or diastereomers, or as stereoisomer mixtures, such as enantiomeric mixtures, for example racemates, diastereomeric mixtures or racemic mixtures; the present invention relates to the pure stereoisomers and also to all possible stereoisomer mixtures, and the above and below are to be understood in this sense in each case, even when stereochemical details are not explicitly mentioned in each case.

[0484] Diastereomeric mixtures or racemic mixtures of the compounds according to the invention in free form or in salt form, the acquisition of which may depend on the starting materials and procedures chosen, can be separated in a known manner into the pure diastereomers or racemates on the basis of the physicochemical differences of the components, for example by fractional crystallization, distillation and / or chromatography.

[0485] Enantiomeric mixtures obtainable in an analogous manner (e.g., racemates) can be resolved into the optical antipodes by known methods, for example, by recrystallization from optically active solvents; by chromatography on chiral adsorbents, for example, high performance liquid chromatography (HPLC) on acetylcellulose; by cleavage with specific immobilized enzymes with the aid of suitable microorganisms; by forming inclusion compounds, for example, using chiral crown ethers, in which only one enantiomer is complexed; or by conversion into diastereomeric salts, for example, by reacting the basic end product racemate with an optically active acid (e.g., a carboxylic acid, for example, camphoric acid, tartaric acid or malic acid, or a sulfonic acid, for example, camphorsulfonic acid) and separating the diastereomeric mixtures obtainable in this way, for example, by fractional crystallization on the basis of their different solubilities, thereby obtaining the diastereomers from which the desired enantiomer can be freed by the action of suitable reagents, for example, basic reagents.

[0486] Pure diastereomers or enantiomers can be obtained according to the invention not only by separation of the appropriate stereoisomer mixtures, but also by generally known methods of diastereoselective or enantioselective synthesis, for example by carrying out the process according to the invention with starting materials having the appropriate stereochemistry.

[0487] N-oxides can be prepared by reacting the compounds according to the invention with a suitable oxidizing agent (e.g. H O / urea adduct) in the presence of an anhydride (e.g. trifluoroacetic anhydride). Such oxidations are known from the literature, for example from J. Med. Chem. 32 (12), 2561-73, 1989 or WO 00 / 15615.

[0488] If the individual components have different biological activities, it is advantageous to isolate or synthesize the biologically more effective stereoisomers, such as enantiomers or diastereomers or stereoisomer mixtures, such as enantiomeric mixtures or diastereomeric mixtures, in each case.

[0489] If appropriate, the compounds according to the invention and, where appropriate, their tautomers (in each case in free form or in salt form) can also be obtained in the form of hydrates and / or include other solvents, such as those which can be used for crystallization of compounds present in solid form.

[0490] The following examples illustrate but do not limit the invention.

[0491] The present invention also provides intermediates useful in preparing the compounds according to the present invention.

[0492] The following intermediates form further aspects of the invention.

[0493] A compound having formula (II)

[0494]

[0495] Among them, ring W Selected from:

[0496]

[0497] wherein * represents the point of attachment to the imidazopyridine group in formula (II), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN;

[0498] A 1 is a carbon atom or a nitrogen atom;

[0499] A 2 is a carbon atom or a nitrogen atom;

[0500] A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A's 3 It's CR 4 ;

[0501] R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group;

[0502] R 2a 、R 2b and R 2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy;

[0503] R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and

[0504] X is Cl, Br or I.

[0505] A compound having formula (XV)

[0506]

[0507] Among them, ring W Selected from:

[0508]

[0509] wherein * represents the point of attachment to the imidazopyridine group in formula (XV), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN;

[0510] A 1 is a carbon atom or a nitrogen atom;

[0511] A 2 is a carbon atom or a nitrogen atom;

[0512] A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A's 3 It's CR 4 ;

[0513] R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group;

[0514] R 2a 、R 2b and R2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and

[0515] R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

[0516] A compound having formula (XXVI)

[0517]

[0518] Among them, ring W Selected from:

[0519]

[0520] wherein * represents the point of attachment to the imidazopyridine group in formula (XXVI), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN;

[0521] A is CH or N;

[0522] A 1 is a carbon atom or a nitrogen atom;

[0523] A 2 is a carbon atom or a nitrogen atom;

[0524] A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A's 3 It's CR 4 ;

[0525] R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group;

[0526] R 2a 、R 2b and R 2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and

[0527] R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, where C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

[0528] A compound having formula (XXII)

[0529]

[0530] Among them, ring W Selected from:

[0531]

[0532] wherein * represents the point of attachment to the imidazopyridine group in formula (XXII) and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, where C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN;

[0533] A 1 is a carbon atom or a nitrogen atom;

[0534] R 2a 、R 2b and R 2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and

[0535] X is Cl, Br or I.

[0536] A compound having formula (XVII)

[0537]

[0538] Wherein A is CH or N;

[0539] R 2a 、R 2b and R 2c Independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy;

[0540] R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6Alkoxyamino, where C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Each of the alkoxyamino groups is optionally substituted with one to three substituents independently selected from halogen and CN; and

[0541] X is Cl, Br or I.

[0542] The compound with formula (I) defined by the present invention can be used as the active ingredient such as for controlling plant pathogens in the agricultural sector and related fields of use, or for controlling spoilage microorganisms or potentially harmful organisms to people on non-living materials. The feature of these novel compounds is to have excellent activity under low application rates, and plant tolerance is good and safe to the environment. They have very useful treatment, prevention and systemic characteristics, and can be used to protect many cultivated plants. The compound with formula (I) defined by the present invention can be used to suppress or destroy the pathogen occurring on the plant or plant part (fruit, flower, leaf, stem, tuber, root) of different useful plant crops, while also protecting those plant parts grown later from the infringement of, for example, plant pathogenic microorganisms.

[0543] Compounds of formula (I) as defined herein may also be used as fungicides. As used herein, the term "fungicide" means a compound that controls, modifies, or prevents the growth of fungi. The term "fungicidally effective amount" means an amount of such a compound or combination of such compounds that is capable of producing an effect on the growth of fungi. Controlling or modifying effects include all deviations from natural development, such as killing, retardation, etc., and prevention includes forming a barrier or other defense in or on a plant to prevent fungal infestation.

[0544] The compound with formula (I) as defined by the present invention can also be used as processing plant propagation material, for example seed (such as fruit, tuber or grain), or the seed dressing of plant cuttings (such as rice), for protecting from fungal infection together with antagonism of the phytopathogenic fungi present in the soil. Can be used before planting with the composition processing propagation material comprising the compound with formula (I) as defined by the present invention: for example, can be seed dressing before sowing. Can also be by dipping seeds in liquid formulations or by coating them with solid formulations, thereby the compound with formula (I) as defined by the present invention is applied to cereals (coating). Can also when planting propagation material, composition is applied to the planting site, for example, is applied to the furrow of seed during sowing. The invention still further relates to this type of method for processing plant propagation material, and relates to the plant propagation material so processed.

[0545] Furthermore, the compounds of formula (I) defined in the present invention can be used for controlling fungi in related fields, for example in the protection of industrial materials (including wood and wood-related technical products), in food storage, in hygiene management.

[0546] Additionally, the present invention can be used to protect non-living materials such as wood, siding, and paint from fungal attack.

[0547] The compounds of formula (I) and fungicidal compositions containing them as defined herein can be used to control plant diseases caused by a broad spectrum of fungal plant pathogens. They effectively control a broad spectrum of plant diseases, such as foliar pathogens of ornamental plants, turf, vegetables, fields, cereals, and fruit crops.

[0548] These fungi and fungal vectors of diseases which can be controlled together with phytopathogenic bacteria and viruses are, for example:

[0549] Psoralea corylifolia, Alternaria species, Aphanomyces species, Ascochyta species, Aspergillus species (including A. flavus, A. fumigatus, A. nidulans, A. niger, A. terreus), Aureobasidium species (including A. pullulans), Blastomyces dermatitidis, B. graminis, Bremia lactucae, Botrytis species (including B. dothidea, B. obtusa), Botrytis species (including B. cinerea), Candida species (including Candida albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis), Cephaloascus fragrans, Cercosporidium species, Cercosporidium species (including C. arachidicola), Cercosporidium personatum, Cladosporium species, Claviceps,

[0550] Coccidioides immitis, Coccidioidomyces species, Colletotrichum species (including C. musae),

[0551] Cryptococcus neoformans, Diaporthe spp., Didymella spp., Entomophthora spp., Entomophthora spp.,

[0552] Epidermophyton species, Erwinia amylovora, Erysiphe species (including E. cichoracearum),

[0553] Grape blight pathogen (Eutypa lata), Fusarium spp. (including Fusarium graminearum, Fusarium graminearum, Fusarium langnerii, Fusarium moniliforme, Fusarium gloeosporium, Fusarium solani, Fusarium oxysporum, and Fusarium laminarum), wheat take-all pathogen (Gaeumannomyces graminis), Gibberella fujikuroi, Gloeodespomigena, Gloeosporium mmusarum, Glomerella cingulate, and Guignardia graminis. bidwellii), Gymnosporangium juniperi-virginianae, Helminthosporium, H. capsulatum, Histoplasma (including H. capsulatum), red thread pathogen, Leptographium lindbergi, Leveillula taurica, Lophodermium seditiosum, Microdochium nivale), Microsporum, Streptoceras, Mucor, Mycosphaeria (including Mycosphaeria graminicola and M. pomi), Blight, Picea, Paracoccidioides, Penicillium (including Penicillium digitatum and Penicillium italicum), Euphrasia, Downy Mildew (including Downy Mildew of maize, Downy Mildew of philippinarum and Downy Mildew of sorghum), Downy Mildew, Septoria glumene, Phellinuigniarus, Phellinuigniarus, Phomopsis, Phomopsis viticola, Phomopsis infestans (including Phomopsis infestans), Monosporus (including Monosporus hallii and P. viticola), Gastrosporium, Pseudomonas (including Pseudomonas leucotricha), Polymyxa graminearum (including Polymyxa graminearum), graminis), Polymyxa betae, Pseudocercosporella herpotrichoides, Pseudomonas, Downy Mildew (including barley rust (P. hordei), wheat leaf rust (P. recondita), stripe rust (P. Striformis), wheat brown rust (P. triticina)), Sclerotinia, Pyricularia, Pyricularia (including rice blast (P.oryzae), Pythium (including Pythium ultimum), Sclerotium, Rhizoctonia, Rhizomucor pusillus, Rhizopus arrhizus, Rhizosporium, Trichosporon (including Scedosporium apiosporum and Scedosporium prolificum), Schizothyrium pomi,

[0554] Sclerotinia species, Sclerotium species, Septoria species (including S. nodorum, S. tritici), Sphaerotheca macularis, Sphaerotheca fusca (Sphaerotheca fuliginea), Sporothorix species, Stagonospora nodorum, Stemphylium species, Stereum hirsutum, Thanatephorus cucumeris, Thielaviopsis basicola, Tilletia species, Trichoderma species (including Trichoderma harzianum, Trichoderma pseudokoningii, Trichoderma viride),

[0555] Trichophyton spp., Cynocystis spp., Uncinaria spp., Urocystis spp., Ustilago spp., Venturia spp. (including V. inaequalis), Verticillium spp., and Xanthomonas spp.

[0556] In particular, the compounds of formula (I) as defined herein and fungicidal compositions containing them can be used to control plant diseases caused by a broad spectrum of fungal plant pathogens from the classes Basidiomycetes, Ascomycetes, Oomycetes and / or Deuteromycetes, Blasocladiomycetes, Chytridiomycetes, Glomeromycetes and / or Mucoromycetes. More particularly, the compounds of formula (I) as defined herein can be used to control Oomycetes.

[0557] These pathogens can include:

[0558] Oomycetes, including Phytophthora diseases such as those caused by Phytophthora capsici, Phytophthora infestans, Phytophthora sojae, Phytophthora fragariae, Phytophthora nicotianae, Phytophthora cinnamomi, Phytophthora citricola, Phytophthora citrophthora, and Phytophthora erythroseptica; Pythium diseases such as those caused by Pythium aphanidermatum, Pythium arrhenomanes, Pythium graminearum, Pythium irregulare, Pythium sylvaticum, and Pythium ultimum; and Peronosporales such as Peronospora serrata. destructor), cabbage downy mildew, grape downy mildew, sunflower downy mildew, cucumber downy mildew, white rust (Albugo candida), rice downy mildew, and lettuce downy mildew; and others, such as Aphanomyces spiralis, Labyrinthula zosterae, Peronosclerospora sorghi, and Sclerospora graminicola.

[0559] Ascomycetes, including stripe, spot, blast or blight and / or rot diseases, such as those caused by the order Stemphylales, such as Stemphylium solani, Stagonospora tainanensis, Oleaceae, Setosphaeria turcica, Pyrenochaeta lycoperisici, Phoma destructiva, Phaeosphaeria herpotrichoides, Phaeocryptocus gaeumannii, Ophiosphaerella graminicola, Ophiobolus graminis, Leptosphaeria maculans, Hendersonia creberrima, Helminthosporium tritici-repentis), Setosphaeria turcica, Drechslera glycines, Didymella bryoniae, Cycloconium oleagineum, Corynespora cassiicola, Cycloconium graminearum, Bipolaris cactivora, Black spot of pitaya, Pyrenophora tritici-repentis, Alternaria interspersed, Alternaria brassicicola, Alternaria solanacea, and Alternaria tomatophila;Capnodiales, such as Septoria spp., Septoria glycines, Cercospora arachidicola, soybean gray spot, corn gray spot, Cercosporella capsellae, and wheat leaf white mold, Cladosporium carpophilum, Cladosporium effusum, Passalora fulva, Cladosporium oxysporum, Dothistromaseptosporum, Isariopsis clavispora, banana black leaf spot, Mycosphaerella graminicola, Mycovellosiella koepkeii), Phaeosariopsis bataticola of sweet potato, Pseudocercospora vitis of grape, wheat base rot, beet leaf spot, Ramularia collo-cygni; Megalochorales such as wheat take-all, Magnaporthe grisea, and Pyricularia oryzae; Mesochorales such as eastern hazelnut wilt, Apiognomonia errabunda, Cytospora platani, northern soybean stem canker, Discula destructiva, Gnomonia fructicola, bitter rot of grape, Melanconium juglandinum, Phomopsis viticola of grape, and Sirococcus clavigignenti-juglandacearum), Tubakia dryina, Dicarpella spp., and Valsa ceratosperma;and others, such as Actinothyrium graminis, Diplosporus gracilis, Aspergillus flavus, Aspergillus fumigatus, Aspergillus nidulans, Blumeriella jaapii, Candida species, Capnodium ramosum, Cephaloascus spp., Cephalosporium gramineum, Ceratocystis paradoxa, Chaetomium species, Hymenoscyphus pseudoalbidus, Coccidioides species, Cylindrosporium padi, Diplocarpon malae, Drepanopeziza campestris, Elsinoe ampelina), Ephemerococcus nigricans, Epidermophyton species, grape dieback, Geotrichum candidum, Gibellina cerealis, Gloeocercospora sorghi, Gloeodes pomigena, and Gloeosporium perennans;Endophytic fungi include Gloeotinia temulenta, Griphospaeria corticola, Kabatiella lini, Leptographium microsporum, Leptosphaerulinia crassiasca, Lophodermium seditiosum, Marssonina graminicola, Microdochium nivale, Monilinia fructicola, Monographella albescens, Monosporascus cannonballus, Naemacyclus spp., Ophiostoma novo-ulmi, Paracoccidioides brasiliensis, and Penicillium expansum), Pestalotia rhododendri, Petriellidium spp., Pezicula spp., Phialophora gregata, Phyllacorapomigena, Phymatotrichum omnivora, Physalospora abdita, Plectosporium tabacinum, Polyscytalumpus tulans, Pseudopeziza medicaginis, Pyrenopeziza brassicae, Ramulispora sorghi, Rhabdocline pseudotsugae, and Rhynchosporium sorghi. secalis), Sacrocladium oryzae, Scedosporium spp., Schizosporium spp. othyrium pomi), Sclerotinia sclerotiorum, Sclerotinia minor; Sclerotium spp., Typhula ishikariensis, Seimatosporium mariae, Lepteutypa cupressi, Septocytaruborum, Sphaceloma perseae, Sporonema phacidioides, Stigmina palmivora, Tapesia yallundae, Taphrina bullata, Thielviopsis basicola, Trichoseptoria fructigena), Zygophialajamaicensis; powdery mildews, for example, those caused by the Powdery Mildews order, such as B. graminis, B. graminis, Sphaerotheca fuligena, Sphaerotheca fuligena, Podospaera macularis, Golovinomyces cichoracearum, Leveillula taurica, Podospaera diffusa, Oidiopsis gossypii, Phyllactinia guttata, and Oidium arachidis; mildews, for example, those caused by Botrytis cinerea, such as Dothiorella aromatica, Diplodia seriata, Guignardia bidwellii, Botrytis cinerea, and Psoralea corylifolia. cinerea), Botryotinia allii, Botryotinia fabae, Fusicoccum amygdali, Lasiodiplodia theobromae, Macrophoma theicola, Coccidioides phaseoli, and Phyllosticta cucurbitacearum;Anthracnose, such as those caused by Glommerelales, such as Colletotrichum lagenarium, Colletotrichum oleraceus, Colletotrichum graminearum, and Colletotrichum graminearum; and blight or disease, such as those caused by Hypocreales, such as Acremonium serratum, Claviceps purpurogenum, Fusarium graminearum, Fusarium virguliforme, Fusarium oxysporum, Fusarium gloeosporum, Fusarium oxysporumf.sp.cubense, Gerlachia nivale, Gibberella fujikura, Gibberella zeae, Glucobra species, Myrocyporus verrucosa, Nectria ramulariae, Trichoderma viride, Trichothecene rosea, and Verticillium theobromae.;

[0560] Basidiomycetes, including powdery mildews such as those caused by the Ustilaginoidea, such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae, rusts such as those caused by stem rust fungi, such as Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, Puccinia cacabata, Puccinia graminis, Puccinia recondita, Puccinia sorghi, Puccinia hordei, Puccinia striiformis f.sp. Hordei), Puccinia striiformis f.sp. Secalis, Pucciniastrum coryli; or those of the Urticales such as Cronartium ribicola, Gymnosporangium juniperi-viginianae, Melampsora medusae, Phakopsora pachyrhizi, etc. zi), Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor, and Uromyces viciae-fabae; and other rots and diseases, such as those caused by Cryptococcus species, Psoralea corylifolia, Marasmiellus inoderma, Agaricus species, Sphacelotheca reiliana, Typhula ishikariensis, Urocystis agropyri, Itersonilia perplexans, Corticium invisum, Laetisaria fuciformis, Waitea circinata, Rhizoctonia solani, Thanetephorus cucurmeris), Entyloma dahliae, Entylomella microspora, Neovossia moliniae, and Tilletia caries.

[0561] Cladomycetes, such as Physoderma maydis.

[0562] Mucorales, e.g. Choanephora cucurbitarum; Mucor species; Rhizopus arrhizus.

[0563] along with diseases caused by other species and genera closely related to those listed above.

[0564] In addition to their fungicidal activity, the compounds and compositions comprising compounds of formula (I) as defined herein may also be active against bacteria such as Erwinia amylovora, Erwinia caratovora, Xanthomonas campestris, Pseudomonas syringae, Strptomyces scabies and other related species, as well as certain protozoa.

[0565] Within the scope of the present invention, target crops and / or useful plants to be protected typically include perennial and annual crops, such as berry plants, for example blackberries, blueberries, cranberries, raspberries and strawberries; cereals, for example barley, maize (corn), millet, oats, rice, rye, sorghum, triticale and wheat; fiber plants, for example cotton, flax, hemp, jute and sisal; field crops, for example sugar beets and fodder beets, coffee beans, hops, mustard, rapeseed (canola), poppy, sugarcane, sunflower, tea and tobacco; fruit trees, for example apples, apricots, avocados, bananas, cherries, citrus, nectarines, peaches, pears and plums; grasses, for example Bermuda grass, bluegrass, bentgrass, centipede grass, fescue, rye, Augustine grass, and zoysia grass; herbs such as basil, borage, chives, cilantro, lavender, lovage, mint, oregano, parsley, rosemary, sage, and thyme; legumes such as beans, lentils, peas, and soybeans; tree nuts such as almonds, cashews, groundnuts, hazelnuts, peanuts, pecans, pistachios, and walnuts; palms such as oil palms; ornamental plants such as flowers, shrubs, and trees; other trees such as cocoa, coconut, olive, and rubber trees; vegetables such as asparagus, eggplant, broccoli, cabbage, carrots, cucumbers, garlic, lettuce, zucchini, melon, okra, onions, peppers, potatoes, pumpkin, rhubarb, spinach, and tomatoes; and vines such as grapes.

[0566] Useful plants and / or target crops according to the invention include conventional as well as genetically enhanced or genetically engineered varieties, such as, for example, insect-resistant (e.g., Bt. and VIP varieties) as well as disease-resistant, herbicide-tolerant (e.g., glyphosate-resistant and glufosinate-resistant maize varieties sold under the trade names Roundup and VIP). and By way of example, suitable genetically enhanced or genetically engineered crop varieties include Stoneville 5599BR cotton and Stoneville 4892BR cotton varieties.

[0567] The terms "useful plants" and / or "target crops" are to be understood as also including useful plants which have been rendered tolerant to herbicides such as bromoxynil or classes of herbicides such as, for example, HPPD inhibitors, ALS inhibitors such as primisulfuron, prosulfuron and trifloxysulfuron, EPSPS (5-enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS (glutamine synthetase) inhibitors or PPO (protoporphyrinogen-oxidase) inhibitors as a result of conventional methods of breeding or genetic engineering. Examples of crops which have been rendered tolerant to imidazolinones such as imazamox by conventional methods of breeding (mutagenesis) are Summer rapeseed (canola). Examples of crops that have been rendered tolerant to herbicides or herbicides by genetic engineering methods include glyphosate-resistant and glufosinate-resistant corn varieties sold under the trade names Roundup Ready and Roundup Ready. Herculex and Commercially available.

[0568] The terms "useful plants" and / or "target crops" are to be understood as including those that are naturally or have been rendered resistant to harmful insects. This includes plants that have been transformed using recombinant DNA technology so as to be able to synthesize, for example, one or more selectively acting toxins, such as are known from, for example, toxin-producing bacteria. Examples of toxins that can be expressed include delta-endotoxins, vegetative insecticidal proteins (Vips), insecticidal proteins of bacterially colonizing nematodes, and toxins produced by scorpions, arachnids, wasps and fungi. Examples of crops that have been modified to express Bacillus thuringiensis toxins are Bt maize. (Syngenta Seeds). Examples of crops that include more than one gene encoding insecticidal resistance and thereby expressing more than one toxin are (Syngenta Seeds). Crops or their seed material can also be resistant to multiple types of pests (so-called stacked transgenic events when produced by genetic modification). For example, a plant can have the ability to express an insecticidal protein while being tolerant to a herbicide, such as Herculex (Dow AgroSciences, Pioneer Hi-Bred International).

[0569] The terms "useful plants" and / or "target crops" are to be understood as also including useful plants that have been transformed using recombinant DNA technology so that they can synthesize selectively active antipathogenic substances, such as, for example, so-called "pathogenesis-related proteins" (PRPs, see, for example, EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants that can synthesize such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95 / 33818, and EP-A-0 353 191. Methods for producing such transgenic plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above.

[0570] Toxins that can be expressed by transgenic plants include, for example, insecticidal proteins from Bacillus cereus or Bacillus japonicus; or insecticidal proteins from Bacillus thuringiensis, such as delta-endotoxins, for example Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C, or vegetative insecticidal proteins (Vips), for example Vip1, Vip2, Vip3, or Vip3A; or insecticidal proteins of nematode-parasitic bacteria, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophila, or Xenorhabdus spp. nematophilus); toxins produced by animals, such as scorpion toxins, spider toxins, bee toxins and other insect-specific neurotoxins; toxins produced by fungi, such as streptomycin, plant lectins, such as pea lectin, barley lectin or snowdrop lectin; lectins (agglutinin); protease inhibitors, such as trypsin inhibitors, serine protease inhibitors, potato glycoproteins, cysteine ​​protease inhibitors, papain inhibitors; ribosome inactivating proteins (RIPs), such as ricin, maize-RIP, abrin, luffain, saporin or bryophyllin; steroid metabolizing enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidase, ecdysteroid inhibitors, HMG-COA-reductase, ion channel blockers, such as sodium channel or calcium channel blockers, juvenile hormone esterase, diuretic hormone receptor, stilbene synthase, bibenzyl synthase, chitinase and glucanase.

[0571] Further, in the context of the present invention, δ-endotoxins (e.g., Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C) or vegetative insecticidal proteins (Vips) (e.g., Vip1, Vip2, Vip3, or Vip3A) should be understood to include, obviously, mixed toxins, truncated toxins, and modified toxins. Mixed toxins are recombinantly produced by new combinations of the different domains of those proteins (see, e.g., WO 02 / 15701). Truncated toxins, such as truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of a naturally occurring toxin are replaced. In such amino acid replacements, it is preferred that a non-naturally occurring protease recognition sequence be inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G recognition sequence is inserted into the Cry3A toxin (see WO 03 / 018810).

[0572] Further examples of such toxins or transgenic plants capable of synthesizing such toxins are disclosed in, for example, EP-A-0 374 753, WO 93 / 07278, WO 95 / 34656, EP-A-0 427 529, EP-A-451 878 and WO 03 / 052073.

[0573] Methods for preparing such transgenic plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95 / 34656, EP-A-0 367474, EP-A-0 401 979 and WO 90 / 13651.

[0574] The toxins contained in the transgenic plants confer tolerance to harmful insects. Such insects can be found in any insect taxonomic group, but are particularly common among beetles (Coleoptera), two-winged insects (Diptera), and moths (Lepidoptera).

[0575] Transgenic plants comprising one or more genes encoding insecticide resistance and expressing one or more toxins are known and some of them are commercially available. Examples of such plants are: (Zea mays variety expressing Cry1Ab toxin); YieldGard (maize variety expressing Cry3Bb1 toxin); YieldGard (Zea mays varieties expressing Cry1Ab and Cry3Bb1 toxins); (Zea mays variety expressing Cry9C toxin); Herculex (a maize variety expressing the Cry1Fa2 toxin and the enzyme phosphinothricin N-acetyltransferase (PAT) that confers tolerance to the herbicide glufosinate-ammonium); NuCOTN (cotton variety expressing Cry1Ac toxin); Bollgard (cotton variety expressing Cry1Ac toxin); Bollgard (cotton varieties expressing Cry1Ac and Cry2Ab toxins); (cotton variety expressing Vip3A and Cry1Ab toxins); (potato variety expressing Cry3A toxin); GT Advantage (GA21 glyphosate tolerance trait), CB Advantage (Bt11 corn borer (CB) trait) and

[0576] Further examples of such genetically modified crops are:

[0577] 1. Bt11 maize, from Syngenta Seeds SAS, 27 Chemin de l'Hobit, F-31 790 St. Sauveur, France, registration number C / FR / 96 / 05 / 10. This genetically modified maize is resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia inermis) by transgenic expression of a truncated Cry1Ab toxin. Bt11 maize also transgenicly expresses the PAT enzyme to confer tolerance to the herbicide glufosinate-ammonium.

[0578] 2. Bt176 maize, from Syngenta Seeds, 27 Rue de Hobbitt, F-31 790 Saint-Sauveur, France, registration number C / FR / 96 / 05 / 10. This genetically modified maize is resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia inermis) by transgenic expression of the toxin Cry1Ab. Bt176 maize also transgenicly expresses the enzyme PAT to confer tolerance to the herbicide glufosinate-ammonium.

[0579] 3. MIR604 maize, from Syngenta Seeds, rue Hobbitt 27, F-31790 Saint-Sauveur, France, registration number C / FR / 96 / 05 / 10. This maize plant is rendered insect-resistant by transgenic expression of a modified Cry3A toxin. This toxin is Cry3A055, modified by insertion of a cathepsin G protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03 / 018810.

[0580] 4. MON 863 maize, from Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / DE / 02 / 9. MON 863 expresses the Cry3Bb1 toxin and confers resistance to certain coleopteran insects.

[0581] 5. IPC 531 cotton, from Monsanto Europe SA, 270-272 Avenue Tervuren, B-1150 Brussels, Belgium, registration number C / ES / 96 / 02.

[0582] 6.1507 maize, from Pioneer Overseas Corporation, Avenue Tedesco, 7B-1160 Brussels, Belgium, registration number C / NL / 00 / 10. Genetically modified maize expressing the protein Cry1F for resistance to certain lepidopteran insects and the protein PAT for tolerance to the herbicide glufosinate.

[0583] 7. NK603×MON 810 maize, from Monsanto Europe, 270-272 Boulevard Tervuren, B-1150 Brussels, Belgium, registration number C / GB / 02 / M3 / 03. This is a conventionally bred hybrid maize variety, constructed by crossing the genetically modified varieties NK603 and MON 810. NK603×MON 810 maize transgenically expresses the protein CP4 EPSPS obtained from the Agrobacterium strain CP4, which confers resistance to herbicides. The strain also expresses the Cry1Ab toxin from Bacillus thuringiensis subsp. kurstakia, which confers tolerance to certain lepidopteran insects, including the European corn borer.

[0584] As used herein, the term "locus" means a place in or on which plants grow, or where seeds of cultivated plants are sown, or where seeds are to be placed in the soil. It includes soil, seeds, and seedlings, as well as established vegetation.

[0585] The term "plant" refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, leaves and fruit.

[0586] The term "plant propagation material" should be construed as meaning the reproductive parts of a plant, such as seeds, which can be used for the propagation of a plant, and vegetative materials, such as cuttings or tubers (e.g., potatoes). Examples of the term "plant propagation material" include seed (strictly speaking), root, fruit, tuber, corm, rhizome, and plant parts. Examples of the term "plant propagation material" include germinated plants and young plants that will be transplanted after germination or after emergence. These young plants can be protected before transplanting by being processed completely or in part by dipping. Preferably, "plant propagation material" should be construed as meaning a seed.

[0587] The pesticides referred to herein using their common names are known, for example, from “The Pesticide Manual”, 19th edition, British Crop Protection Council 2021.

[0588] The compound with formula (I) defined by the present invention can be used in unmodified form, or preferably, used together with the adjuvant conventionally adopted in the preparation field.For this purpose, they can be conveniently formulated as emulsifiable concentrates, pastes that can be coated, directly sprayable or dilutable solutions or suspensions, dilute emulsions, wettable powders, soluble powders, pulvis, granules and also capsules (for example in polymeric substances) in a known manner.For the type of composition, according to the intended purpose and the environment at that time, application method is selected, such as spraying, atomizing, dusting, broadcasting, smearing or watering.Composition can also contain other adjuvants, such as stabilizers, defoamers, viscosity modifiers, adhesives or tackifiers, together with fertilizers, micronutrient donors or other preparations for obtaining special effects.

[0589] Suitable carriers and / or adjuvants, for example for agricultural use, can be solid or liquid and are substances useful in formulation technology, such as natural or regenerated mineral substances, solvents, dispersants, wetting agents, tackifiers, thickeners, adhesives or fertilizers. Such carriers are for example described in WO 97 / 33890.

[0590] Suspension concentrates are aqueous formulations in which finely divided solid particles of the active compound are suspended. Such formulations contain anti-settling agents and dispersants and may further include wetting agents to enhance activity, as well as defoamers and crystal growth inhibitors. For use, these concentrates are diluted in water and typically applied as a spray to the area to be treated. The amount of active ingredient can range from 0.5% to 95% of the concentrate.

[0591] Wettable powders are in the form of finely divided particles that disperse easily in water or other liquid carriers. These particles contain the active ingredient held within a solid matrix. Typical solid matrices include Fuller's earth, kaolin, silica, and other readily wettable organic or inorganic solids. Wettable powders typically contain from 5% to 95% active ingredient plus a small amount of a wetting agent, dispersant, or emulsifier.

[0592] Emulsifiable concentrates are homogeneous liquid compositions dispersible in water or other liquids and may consist entirely of the active compound and a liquid or solid emulsifier, or may also contain a liquid carrier such as xylene, heavy aromatic naphtha, isophorone, and other nonvolatile organic solvents. In use, these concentrates are dispersed in water or other liquids and typically applied as a spray to the area to be treated. The amount of active ingredient may range from 0.5% to 95% of the concentrate.

[0593] Granular formulations include both extrudates and coarser granules and are typically applied undiluted to the area to be treated. Typical carriers for granular formulations include sand, fuller's earth, attapulgite clay, bentonite, montmorillonite, vermiculite, perlite, calcium carbonate, brick, pumice, pyrophyllite, kaolin, dolomite, plaster, wood flour, crushed corn cobs, crushed peanut shells, sugar, sodium chloride, sodium sulfate, sodium silicate, sodium borate, magnesium oxide, mica, iron oxide, zinc oxide, titanium oxide, antimony oxide, cryolite, gypsum, diatomaceous earth, calcium sulfate, and other organic or inorganic materials that absorb or can be coated with the active compound. Granular formulations typically contain 5% to 25% active ingredient, which may include surfactants such as heavy aromatic naphtha, kerosene and other petroleum fractions, or vegetable oils; and / or adhesives such as dextrins, glues, or synthetic resins.

[0594] Dusts are free-flowing mixtures of the active ingredient with finely divided solids such as talc, clay, flour and other organic and inorganic solids which act as dispersants and carriers.

[0595] Microcapsules are typically droplets or particles of the active ingredient encapsulated within an inert porous shell that allows the encapsulated material to escape into the environment at a controlled rate. The encapsulated droplets typically have a diameter of 1 to 50 microns. The encapsulated liquid typically accounts for 50% to 95% of the capsule's weight and may contain a solvent in addition to the active compound. The encapsulated particles are usually porous particles, in which a porous membrane seals the particle pores, retaining the active species in liquid form within the particle pores. The particle diameter typically ranges from 1 mm to 1 cm and preferably 1 mm to 2 mm. The particles are formed by extrusion, coagulation, or spheronization, or are naturally occurring. Examples of such materials include vermiculite, sintered clay, kaolin, attapulgite clay, sawdust, and carbon granules. Shell or membrane materials include natural and synthetic rubbers, fiber materials, styrene-butadiene copolymers, polyacrylonitrile, polyacrylates, polyesters, polyamides, polyureas, polyurethanes, and starch xanthate.

[0596] Other useful formulations for agrochemical applications include simple solutions of the active ingredient in a solvent (such as acetone, alkylated naphthalenes, xylene and other organic solvents) in which the active ingredient is completely soluble at the desired concentration. Pressurized sprays can also be used, in which the active ingredient is dispersed in finely divided form due to evaporation of a low-boiling dispersant solvent carrier.

[0597] Suitable agricultural adjuvants and / or carriers useful for formulating the compositions of the present invention in the above-mentioned formulation types are well known to those skilled in the art.

[0598] Liquid carriers that can be used include, for example, water, toluene, xylene, naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, acetic anhydride, acetonitrile, acetophenone, amyl acetate, 2-butanone, chlorobenzene, cyclohexane, cyclohexanol, alkyl acetates, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol rosin acid ester, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethyl Formamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, dipropylene glycol (diproxitol), alkyl pyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, α-pinene, d-limonene, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, γ-butyrolactone, glycerol, glycerol diacetate, glycerol monoethyl Acid esters, triacetin, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, cumene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, dichloromethane, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate, oleic acid, oleylamine, o-xylene, phenol, polyol Ethylene glycol (PEG400), propionic acid, propylene glycol, propylene glycol monomethyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylenesulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, methanol, ethanol, isopropanol, and higher molecular weight alcohols (such as amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, etc.), ethylene glycol, propylene glycol, glycerol, and N-methyl-2-pyrrolidone. Water is generally the carrier of choice for dilution of concentrates.

[0599] Suitable solid carriers include, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kieselguhr, chalk, diatomaxeous earth, lime, calcium carbonate, bentonite, Fuller's earth, cottonseed hulls, wheat flour, soy flour, pumice, wood flour, walnut shell flour, and lignin.

[0600] A wide range of surfactants are advantageously employed in the liquid and solid compositions, especially those designed to be diluted with a carrier prior to application. These agents, when used, typically comprise from 0.1% to 15% by weight of the formulation. They may be anionic, cationic, nonionic, or polymeric in nature and may serve as emulsifiers, wetting agents, suspending agents, or for other purposes. Typical surfactants include alkyl sulfates such as diethanolammonium lauryl sulfate; alkylaryl sulfonates such as calcium dodecylbenzenesulfonate; alkylphenol-alkylene oxide addition products such as nonylphenol-C.sub.18 ethoxylate; alcohol-alkylene oxide addition products such as tridecyl alcohol-C.sub.16 ethoxylate; soaps such as sodium stearate; alkylnaphthalenesulfonates such as sodium dibutylnaphthalenesulfonate; salts of dialkyl sulfosuccinates such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters such as sorbitol oleate; quaternary amines such as lauryltrimethylammonium chloride; polyethylene glycol esters of fatty acids such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono- and dialkyl phosphates.

[0601] Other adjuvants commonly used in agricultural compositions include crystallization inhibitors, viscosity modifiers, suspending agents, spray droplet regulators, pigments, antioxidants, foaming agents, defoamers, opacifiers, compatibilizing agents, antifoaming agents, masking agents, neutralizing and buffering agents, corrosion inhibitors, dyes, flavor enhancers, spreading agents, penetration aids, micronutrients, emollients, lubricants, and fixatives.

[0602] In addition, further, other biocidal active ingredients or compositions can be combined with the composition of the present invention and used in the method of the present invention and applied simultaneously or sequentially with the composition of the present invention. When applied simultaneously, these other active ingredients can be formulated together with the composition of the present invention or mixed in, for example, a spray tank. These other biocidal active ingredients can be fungicides, weedicides, insecticides, bactericides, acaricides, nematicides, plant growth regulators and / or biological preparations.

[0603] Preference is given to the following combinations of a compound of formula I with another active substance in a weight ratio of 1:1 (wherein the abbreviation "TX" means "a compound selected from the group consisting of the compounds defined in Tables 1.1 to 1.162 and Table A"):

[0604] An auxiliary agent selected from the group consisting of: petroleum (alias) (628) + TX;

[0605] Abamectin + TX, acetamiprid + TX, acetamiprid + TX, acetofluanid + TX, flumethrin + TX, acynonapyr + TX, cyclohexanil + TX, afoxolaner + TX, cotton boll carbendazim + TX, allethrin + TX, α-cypermethrin + TX, alpha-cypermethrin + TX, sulfamethoxazole + TX, cypermethrin + TX, triazotin + TX, sulfamethoxazole + TX, benzyltrimethoxam + TX, benzpyrimoxan + TX, β-cyfluthrin + TX, β-cypermethrin + TX, bifenazate + TX, bifenthrin + TX, binapacryl + TX, bioallethrin + TX, S-bioallethrin +TX, bio-resmethrin+TX, bistrifluan+TX, broflanilide+TX, brofluthrin+TX, bromophos-ethyl+TX, buprofezin+TX, butacarb+TX, cadusafos+TX, carbaryl+TX, butacarb+TX, batan+TX, CAS No.: 1632218-00-8+TX, CAS No.: 1808115-49-2+TX, CAS No.: 2032403-97-5+TX, CAS No.: 2044701-44-0+TX, CAS No.: 2128706-05-6+TX, CAS No.: 2095470-94-1+TX, CAS No.: 237708 4-09-6+TX、CAS No.:1445683-71-5+TX、CAS No.:2408220-94-8+TX、CAS No.:2408220-91-5+TX、CAS No.:1365070-72-9+TX、CAS No.:2171099-09-3+TX、CAS No.:2396747-83-2+TX、CAS No.:2133042-31-4+TX、CAS No.:2133042-44-9+TX、CAS No.:1445684-82-1+TX、CAS No.:1445684-82-1+TX、CAS No.:1922957-45-6+TX、CAS No.: 1922957-46-7+TX、CAS No.:1922957-47-8+TX、CAS No.:1922957-48-9+TX、CAS No.:2415706-16-8+TX、CAS No.:1594624-87-9+TX、CAS No.:1594637-65-6+TX、CAS No.:1594626-19-3+TX、CAS No.:1990457-52-7+TX、CAS No.:1990457-55-0+TX、CAS No.:1990457-57-2+TX、CAS No.:1990457-77-6+TX、CAS No.:1990457-66-3+TX、CAS No.: 1990457-85-6+TX, CAS No.: 2220132-55-6+TX, CAS No.: 1255091-74-7+TX, CAS No.: 2719848-60-7+TX, CAS No.: 1956329-03-5+TX, chlorantraniliprole+TX, chlordane+TX, chlorfenapyr+TX, chlorpromazide+TX, chloranil+TX, chlorfenapyr+TX, chlorfenapyr+TX, clenpyrine+TX, cloethocarb+TX, clothianidin+TX, 2-chlorophenyl N-methylcarbamate (CPMC)+TX, benzonitrile+TX, cyanantraniliprole+TX, cyclobromofenapyr+TX, cyclobutrifluanid+TX ram)+TX, pyrethroids+TX, cycloxanthrin+TX, cytoxanil+TX, cyetpyrafen+TX, cyetpyrafen or etpyrafen+TX, cyfluthrin+TX, cyhalodiamide+TX, cyhalothrin+TX, cypermethrin+TX, cypermethrin+TX, cyproflanilide+TX, cyromazine+TX, deltamethrin+TX, cyprofenuron+TX, chlorfenapyr ... Dimpropyridaz + TX, diprofenac + TX, dinotefuran + TX, vegetable phosphorus + TX, emamectin (or emamectin benzoate) + TX, dextromethorphine + TX, epsilon-momfluorothrin + TX, epsilon-metofluthrin + TX, cypermethrin + TX, ethion + TX, ethomethrin + TX, etoxazole + TX, fenmethrin + TX, fenazaquin + TX, fenfluramide + TX, pentothrin + TX, fenmezoditiaz + TX, fenitrothion + TX, fenobucarb + TX, fenthiocarb + TX, fenoxycarb + TX, cypermethrin + TX, azole Fenpyroximate + TX, fenpyrophos + TX, fenthion + TX, cypermethrin + TX, fipronil + TX, flometoquin + TX, flonicamid + TX, cypermethrin + TX, fluazaindolizine + TX, flupyralid + TX, flubendiamide + TX, fluchlordiniliprole + TX, flucitrinate + TX, flufenoxuron + TX, flucythrin + TX, fluthiazolin + TX, flumethrin + TX, flumethrin + TX, flumethrin + TX, flufenoxam + TX, fluchlordiniliprole + TX, flucitrinate + TX, flufenoxuron + TX, flucythrin + TX, fluthiazolin + TX, flumethrin + TX, flufenoxam + TX, flumethrin + TX, butenefipronil + TX,Fluhexafon + TX, fluchlorfenapyr + TX, fluopyram + TX, flupentiofenox + TX, flupyroxystrobin + TX, flupyrimin + TX, fluralaner + TX, fluvalinate + TX, fluxametamide + TX, thiazolin + TX, gamma-cyhalothrin + TX, pyrimidine + TX, chlorfenapyr + TX, benzyl ammonium chloride + TX, heptafluthrin + TX, hexythiazox + TX, hydrazone + TX , imicyafos + TX, imidacloprid + TX, imiprodinil + TX, indazapyroxamet + TX, indoxacarb + TX, iodomethane + TX, iprodione + TX, isocycloseram + TX, isothiocarb + TX, ivermectin + TX, κ-bifenthrin + TX, κ-tefluthrin + TX, λ-cyhalothrin + TX, ledprona + TX, lepidomycin + TX, lotilaner + TX, chlorfenuron + TX, metaflumizone + TX, metaldehyde + TX, methomyl + TX, methomyl + TX, methoxyfenozide + TX, trimethoprim-fluthrin Pyrethroids + TX, pyrethroids + TX, chlorpyrifos + TX, cypermethrin + TX, momfluorothrin + TX, cypermethrin + TX, nicofluprole + TX; nitenpyram + TX, nithiazine + TX, omethoate + TX, oxamyl + TX, oxazosulfyl + TX, parathion-ethyl + TX, permethrin + TX, phenothrin + TX, phosphamidon + TX, piperonyl butoxide + TX, pirimicarb + TX, pyrimidophos-ethyl + TX, pyrimidophos-methyl + TX, polyhedrosis virus + TX, prallethrin + TX, profenofos + TX, profluthrin + TX, propargite + TX, fenvalerate + TX, propoxur + TX X, prothiophos + TX, protrifenbute + TX, pyflubumide + TX, pymetrozine + TX, pyraclostrobin + TX, pyrafluprole + TX, pyridaben + TX, pyridalyl + TX, pyrifluquinazon + TX, pyrimidine + TX, pyrimidine + TX, pyrifluquinazon + TX, pyrimidine + TX, pyriflufen + TX, resfurox + TX, salolanab + TX, selamectin + TX, silafluthrin + TX, spinosad + TX, spinosad + TX, spirobudicin + TX, spiromesifen + TX, spiromesifen + TX,spiropidion+TX, spirotetramat+TX, spidoxamat+TX, sulfonecarb+TX, tebufenozide+TX, tebufenpyrad+TX, butylpyrimidinphos+TX, tefluthrin+TX, tebufenac+TX, tetrafluthrin+TX, tetrachlorfenapyr+TX, tetrachlorfenapyr+TX, tetrafluthrin+TX, acaricide+TX, flucythamide+TX, θ-cypermethrin+TX, thiacloprid+TX, thiamethoxam+TX, thiocarb+TX, thiodicarb+TX, long-lasting carb+TX, methyl sulfophos+TX, thiophanate+TX, tigolaner+TX, sulfanilamide+TX, tioxazafen+TX, tolfenpyrad+TX, toxaphene+TX, tralomethrin+TX, transfluthrin+TX, triazophos+TX, trichlorfon+TX, chlorpyrifos+TX, trichlorfon+TX, trifloxystrobin ( trifluenfuronate)+TX, triflumezopyrim+TX, tyclopyrazoflor+TX, ζ-cypermethrin+TX, seaweed extract and fermentation products derived from sugar acyl+TX, seaweed extract and fermentation products derived from sugar acyl (containing urea+TX, amino acids+TX, potassium and molybdenum, and EDTA-chelated manganese)+TX, seaweed extract and fermented plant products+TX, seaweed extract and fermented plant products (containing plant hormones+TX, vitamins+TX, EDTA-chelated copper+TX, zinc+TX, and iron+TX), azadirachtin+TX, Bacillus aizawai+TX, Bacillus chitinosporus AQ746 (NRRL Accession No. B-21 618)+TX, Bacillus firmus+TX, Bacillus kurstak Kurstaki) + TX, Bacillus mycoides AQ726 (NRRL Accession No. B-21664) + TX, Bacillus pumilus (NRRL Accession No. B-30087) + TX, Bacillus pumilus AQ717 (NRRL Accession No. B-21662) + TX, Bacillus species AQ178 (ATCC Accession No. 53522) + TX, Bacillus species AQ175 (ATCC Accession No. 55608) + TX, Bacillus species AQ177 (ATCC Accession No. 55609) + TX, unspecified Bacillus subtilis + TX, Bacillus subtilis AQ153 (ATCC Accession No. 55614)+TX, Bacillus subtilis AQ30002 (NRRL Accession No. B-50421)+TX, Bacillus subtilis AQ30004 (NRRL Accession No. B-50455)+TX, Bacillus subtilis AQ713 (NRRL Accession No. B-21661)+TX, Bacillus subtilis AQ743 (NRRL Accession No. B-21665)+TX, Bacillus thuringiensis AQ52 (NRRL Accession No. B-21619)+TX, Bacillus thuringiensis BD#32 (NRRL Accession No. B-21530)+TX, Bacillus thuringiensis subsp. Kurstaki (subspec.Kurstaki) BMP 123+TX, Beauveria bassiana+TX, D-limonene+TX, Granulovirus+TX, Harpin+TX, Helicoverpa armigera nuclear polyhedrosis virus+TX, Heliothis corneum nuclear polyhedrosis virus+TX, Heliothis virescens nuclear polyhedrosis virus+TX, Australian Helicoverpa armigera nuclear polyhedrosis virus+TX, Metarhizium species+TX, Muscodor albus 620 (NRRL accession number 30547)+TX, Muscodor roseusA3-5 (NRRL accession number 30548) + TX, neem-based products + TX, Paecilomyces fumosorum + TX, Paecilomyces lilacinus + TX, Pasteuria szabalensis + TX, Pasteuria penetrantis + TX, Pasteuria mycoides + TX, Pasteuria thornei + TX, Pasteuria + TX, p-cymene + TX, Plutella xylostella granulosis virus + TX, Plutella xylostella nuclear polyhedrosis virus + TX, polyhedrosis virus + TX, pyrethrum + TX, QRD 420 (terpenoid blend) + TX, QRD 452 (terpenoid blend) + TX, QRD460 (terpenoid blend) + TX, Quillaja saponaria + TX, Rhodococcus sphaeroides AQ719 (NRRL Accession No. B-21663) + TX, Spodoptera frugiperda nuclear polyhedrosis virus + TX, Streptomyces flavus (NRRL Accession No. 30232) + TX, Streptomyces sp. (NRRL Accession No. B-30145) + TX, terpenoid blend + TX, and Verticillium sp. + TX;

[0606] an algaecide selected from the group consisting of bethoxazin [CCN] + TX, copper dioctanoate (IUPAC name) (170) + TX, copper sulfate (172) + TX, cybutryne [CCN] + TX, dichlone (1052) + TX, dichlorophen (232) + TX, endoxan (295) + TX, fentin (347) + TX, slaked lime [CCN] + TX, nabam (566) + TX, quinoclamine (714) + TX, quinonamid (1379) + TX, simazine (730) + TX, triphenyltin acetate (IUPAC name) (347) + TX, and triphenyltin hydroxide (IUPAC name) (347) + TX;

[0607] Anthelmintics selected from the group consisting of: avermectin (1) + TX, clefonate (1011) + TX, cyclopentane + TX, doramectin (alias) [CCN] + TX, emamectin (291) + TX, emamectin benzoate (291) + TX, eprinomectin (alias) [CCN] + TX, ivermectin (alias) [CCN] + TX, milbemycin oxime (alias) [CCN] + TX, moxidectin (alias) [CCN] + TX, piperazine [CCN] + TX, selamectin (alias) [CCN] + TX, spinosad (737) + TX and thiophanate (1435) + TX;

[0608] Avicides selected from the group consisting of chloralose (127) + TX, endrin (1122) + TX, fenthion (346) + TX, pyridin-4-amine (IUPAC name) (23) + TX and strychnine (745) + TX;

[0609] Bactericide selected from the group consisting of: 1-hydroxy-1H-pyridine-2-thione (IUPAC name) (1222) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, 8-hydroxyquinoline sulfate (446) + TX, bronopol (97) + TX, copper dioctanoate (IUPAC name) (170) + TX, copper hydroxide (IUPAC name) (169) + TX, cresol [CCN] + TX, dichlorophen (232) + TX, dipyrithione (1105) + TX, dodesine (1112) + TX, fenaminosulf (1144) + TX, formaldehyde (404) + TX, mercaptophenone ( Synonyms) [CCN] + TX, kasugamycin (483) + TX, kasugamycin hydrochloride hydrate (483) + TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308) + TX, nitrapyrin (580) + TX, octhilinone (590) + TX, oxolinic acid (606) + TX, oxytetracycline (611) + TX, potassium hydroxyquinoline sulfate (446) + TX, probenazole (658) + TX, streptomycin (744) + TX, streptomycin sesquisulfate (744) + TX, chlorpheniramine (766) + TX, and thimerosal (synonyms) [CCN] + TX;

[0610] A biological agent selected from the group consisting of: GV of cotton brown banded moth (alias) (12) + TX, Agrobacterium radiobacterium (alias) (13) + TX, Amblyseius spp. (alias) (19) + TX, NPV of celery budworm (alias) (28) + TX, Anagrus atomus (alias) (29) + TX, Aphelinus abdominalis (alias) (33) + TX, Aphidius colemani (alias) (34) + TX, Aphidoletes aphidimyza (alias) (35) + TX, NPV of lucerne budworm (alias) (38) + TX, Bacillus firmus (alias) (48) + TX, Bacillus sphaericus Neide)(scientific name)(49)+TX、Bacillus thuringiensis Berliner)(scientific name)(51)+TX、Bacillus thuringiensis subsp.aizawai)(scientific name)(51)+TX、Bacillus thuringiensis subsp.israelensis)(scientific name)(51)+TX、Bacillus thuringiensis subsp.japonensis)(scientific name)(51)+TX、Bacillus thuringiensis subsp.kurstaki)(scientific name)(51)+TX、Bacillus thuringiensis subsp.tenebrionis (scientific name) (51) + TX, Beauveria bassiana (alias) (53) + TX, Beauveria brongniartii (alias) (54) + TX, Chrysoperla carnea (alias) (151) + TX, Cryptolaemus montrouzieri (alias) (178) + TX, Codling moth GV (alias) (191) + TX, Dacnusa sibirica (alias) (212) + TX, Diglyphus isaea (alias) (254) + TX, Eretmocerus sibirica (scientific name) (293) + TX, Eretmocerus sibirica (alias) eremicus) (alias) (300) + TX, Spodoptera exigua NPV (alias) (431) + TX, Heterorhabditis bacteriophora and H. megidis (alias) (433) + TX, Hippodamia convergens (alias) (442) + TX, Leptomastix dactylopii (alias) (488) + TX, Macrolophus caliginosus (alias) (491) + TX, Spodoptera exigua NPV (alias) (494) + TX, Metaphycus helvolus (alias) (522) + TX, Metarhizium anisopliae var.acridum)(scientific name)(523)+TX, Metarhizium anisopliae var. anisopliae)(scientific name)(523)+TX, Neodiprion sertifer NPV and Neodiprion sertifer (Neodiprion sertifer) NPV.lecontei)NPV (alias) (575) + TX, Paecilomyces species (alias) (596) + TX, Paecilomyces fumosoroseus (alias) (613) + TX, Phytoseiulus persimlis (alias) (644) + TX, Spodoptera exigua multicapsidnuclear polyhedrosis virus (scientific name) (741) + TX, Steinernema bibionis (alias) (742) + TX, Steinernema carpocapsae (alias) (742) + TX, Steinernema glaseri (alias) (742) + TX, Steinernema riobrave) (alias) (742) + TX, Steinernema riobravis (alias) (742) + TX, Steinernema scapterisci (alias) (742) + TX, Steinernema spp. (alias) (742) + TX, Trichogramma spp. (alias) (826) + TX, Typhlodromus occidentalis (alias) (844) + TX, and Verticillium lecanii (alias) (848) + TX;

[0611] Soil disinfectants selected from the group consisting of iodomethane (IUPAC name) (542) + TX and bromomethane (537) + TX;

[0612] A chemical sterilant selected from the group consisting of: apholanate [CCN] + TX, bis(aziridine) methylaminophosphine sulfide (bisazir) (alias) [CCN] + TX, busulfan (alias) [CCN] + TX, diflubenzuron (250) + TX, dimatif (alias) [CCN] + TX, hemel [CCN] + TX, hempa [CCN] + TX, metepa [CCN] + TX, methylthiothion Methotepa [CCN] + TX, methylapholate [CCN] + TX, morzid [CCN] + TX, penfluron (other name) [CCN] + TX, tepa [CCN] + TX, thiohempa (other name) [CCN] + TX, thiotepa (other name) [CCN] + TX, trotamide (other name) [CCN] + TX, and urethaneimide (other name) [CCN] + TX;

[0613] An insect pheromone selected from the group consisting of (E)-dec-5-en-1-yl acetate and (E)-dec-5-en-1-ol (IUPAC name) (222) + TX, (E)-tridec-4-en-1-yl acetate (IUPAC name) (829) + TX, (E)-6-methylhept-2-en-4-ol (IUPAC name) (541) + TX, (E,Z)-tetradec-4,10-dien-1-yl acetate (IUPAC name) (779) + TX, (Z)-dodec-7-en-1-yl acetate (IUPAC name) (285) + TX, (Z)-hexadecan-11-enal (IUPAC name) (436) + TX, (Z)-hexadecan-11-en-1-yl acetate (IUPAC name) (437) + TX X, (Z)-hexadec-13-en-11-yn-1-yl acetate (IUPAC name) (438) + TX, (Z)-eicos-13-en-10-one (IUPAC name) (448) + TX, (Z)-tetradec-7-en-1-al (IUPAC name) (782) + TX, (Z)-tetradec-9-en-1-ol (IUPAC name) (783) + TX, (Z)-tetradec-9-en-1-yl acetate (IUPAC name) (784) + TX, (7E,9Z)-dodec-7,9-dien-1-yl acetate (IUPAC name) (283) + TX, (9Z,11E)-tetradec-9,11-dien-1-yl acetate (IUPAC name) (780) + TX, (9Z,12E)-tetradec-9,12-Dien-1-yl acetate (IUPAC name) (781) + TX, 14-methyloctadec-1-ene (IUPAC name) (545) + TX, 4-methylnonan-5-ol and 4-methylnonan-5-one (IUPAC name) (544) + TX, alpha-multistriatin (alias) [CCN] + TX, western pine beetle gathering pheromone (brevicomin) (alias) [CCN] + TX, codlelure (alias) [CCN] + TX, codlemone (alias) (167) + TX, cuelure (alias) ( 179)+TX, disparlure (277)+TX, dodec-8-en-1-yl acetate (IUPAC name) (286)+TX, dodec-9-en-1-yl acetate (IUPAC name) (287)+TX, dodec-8+TX, 10-dien-1-yl acetate (IUPAC name) (284)+TX, dominicalure (alias) [CCN]+TX, ethyl 4-methyloctanoate (IUPAC name) (317)+TX, eugenol (alias) [CCN]+TX, southern pine beetle aggregation pheromone (frontalin) (alias) [CCN]+TX, 1:1 mixture of (Z,E) and (Z,Z) isomers of (hexadec-7,11-dien-1-yl acetate) (420) + TX, grandlure (421) + TX, grandlure I (alternative name) (421) + TX, grandlure II (alternative name) (421) + TX, grandlure III (alternative name) (421) + TX, grandlure IV (alternative name) (421) + TX, hexalure [CCN] + TX, ipsdienol (alternative name) [ CCN]+TX, ipsenol (alias) [CCN]+TX, japonilure (alias) (481)+TX, lineatin (alias) [CCN]+TX, litlure (alias) [CCN]+TX, looplure (alias) [CCN]+TX, medlure [CCN]+TX, (3E,5Z)-tetradec-3,5-dienoic acid (megatomoic acid)(alias)[CCN]+TX、methyleugenol)(alias)(540)+TX、muscalure(563)+TX、octadec-2,13-dien-1-yl acetate(IUPAC name)(588)+TX、octadec-3,13-dien-1-yl acetate(IUPAC name)(589)+TX、orfralure(alias)[CCN]+TX、oryctalure(alias)(317)+TX、ostramone(alias)[CCN]+TX、s iglure) [CCN] + TX, banana bulb weevil attractant (sordidin) (alias) (736) + TX, fungivorous methyl attractant (sulcatol) (alias) [CCN] + TX, tetradec-11-en-1-yl acetate (IUPAC name) (785) + TX, Mediterranean fruit fly attractant (839) + TX, Mediterranean fruit fly attractant A (alias) (839) + TX, Mediterranean fruit fly attractant B1 (alias) (839) + TX, Mediterranean fruit fly attractant B2 (alias) (839) + TX, Mediterranean fruit fly attractant C (alias) (839) TX and trunc-call (alias) [CCN] + TX;

[0614] Insect repellents selected from the group consisting of 2-(octylthio)ethanol (IUPAC name) (591) + TX, butopyronoxyl (933) + TX, butoxy(polypropylene glycol) (936) + TX, dibutyl adipate (IUPAC name) (1046) + TX, dibutyl phthalate (1047) + TX, dibutyl succinate (IUPAC name) (1048) + TX, DEET [CCN] + TX, dimethylcarbate [CCN] + TX, dimethyl phthalate [CCN] + TX, ethyl hexanediol (1137) + TX, hexylurea [CCN] + TX, methoquin-butyl (1276) + TX, methylneodecanamide [CCN] + TX, oxamate [CCN] + TX, and picaridin [CCN] + TX;

[0615] Molluscicide selected from the group consisting of: di(tributyltin) oxide (IUPAC name) (913) + TX, bromoacetamide [CCN] + TX, calcium arsenate [CCN] + TX, chloranil (999) + TX, copper acetyl arsenite [CCN] + TX, copper sulfate (172) + TX, triphenyltin (347) + TX, iron phosphate (IUPAC name) (352) + TX, metaldehyde (518) + TX, methiocarb (530) + TX, niclosamide (576) + TX, niclosamide-ethanolamine (576) + TX, pentachlorophenol (62 3)+TX, sodium pentachlorophenoxide (623)+TX, tazimcarb (1412)+TX, thiodicarb (799)+TX, tributyltin oxide (913)+TX, trifenmorph (1454)+TX, trimethacarb (840)+TX, triphenyltin acetate (IUPAC name) (347)+TX, triphenyltin hydroxide (IUPAC name) (347)+TX, and pyriprole [394730-71-3]+TX;

[0616] A nematicide selected from the group consisting of: AKD-3088 (compound code) + TX, 1,2-dibromo-3-chloropropane (IUPAC / Chemical Abstracts name) (1045) + TX, 1,2-dichloropropane (IUPAC / Chemical Abstracts name) (1062) + TX, 1,2-dichloropropane and 1,3-dichloropropene (IUPAC name) (1063) + TX, 1,3-dichloropropene (233) + TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide (IUPAC / Chemical Abstracts name) Abstract name) (1065) + TX, 3-(4-chlorophenyl)-5-methylrhodanine (IUPAC name) (980) + TX, 5-methyl-6-thioxo-1,3,5-thiadiazin-3-yl acetic acid (IUPAC name) (1286) + TX, 6-isopentenylaminopurine (alias) (210) + TX, avermectin (1) + TX, acetofenamide [CCN] + TX, cotton bell carb (15) + TX, aldicarb (16) + TX, aldicarb (863) + TX, AZ 60541 (compound code) + TX, benclothiaz [CCN] + TX, benomyl (62) + TX, butylpyridaben (alias) + TX, chlorpyrifos (109) + TX, carbofuran (118) + TX, carbon disulfide (945) + TX, carbofuran (119) + TX, chloropicrin (141) + TX, chlorpyrifos (145) + TX, Wei (999) + TX, cyclobutaflutol + TX, cytokinin (alias) (210) + TX, dazomethane (216) + TX, DBCP (1045) + TX, DCIP (218) + TX, diamidafos (1044) + TX, dimethoate (1051) + TX, dicliphos (alias) + TX, dimethoate (262) + TX, doramectin (alias) [ CCN]+TX, emamectin (291)+TX, emamectin benzoate (291)+TX, eprinomectin (alias) [CCN]+TX, ethoprophos (312)+TX, dibromoethane (316)+TX, fenamiphos (326)+TX, fenpyrad (alias)+TX, fensulfuron (1158)+TX, thiazophos (408)+TX, butasulfophos (1196)+TX, furfural Aldehyde (alias) [CCN] + TX, GY-81 (research code) (423) + TX, cypermethrin [CCN] + TX, iodomethane (IUPAC name) (542) + TX, isamidophos (1230) + TX, chlorfenapyr (1231) + TX, ivermectin (alias) [CCN] + TX, kinetin (alias) (210) + TX, methyl aphidoxime (1258) + TX,Metamex (519) + TX, Metamex potassium salt (alias) (519) + TX, Metamex sodium salt (519) + TX, methyl bromide (537) + TX, methyl isothiocyanate (543) + TX, milbemycin oxime (alias) [CCN] + TX, moxidectin (alias) [CCN] + TX, Myrothecium verrucaria composition (alias) (565) + TX, NC-184 (compound code) + TX, oxamyl (602) + TX, methyl parathion (636) + TX, phosphamidon (639) + TX, phosphamidon [CCN] + TX, chlorpyrifos (alias) + TX, selamectin (alias) [ CCN]+TX, spinosad (737)+TX, terbufos (alias)+TX, terbufos (773)+TX, tetrachlorothiophene (IUPAC / Chemical Abstracts name) (1422)+TX, thiafenox (alias)+TX, fenamiphos (1434)+TX, triazophos (820)+TX, triazuron (alias)+TX, xylenol [CCN]+TX, YI-5302 (compound code)+TX, zeatin (alias) (210)+TX, fluensulfone [318290-98-1]+TX, and fluopyram+TX;

[0617] A nitrification inhibitor selected from the group consisting of potassium ethylxanthate [CCN] + TX and nitrapyrin (580) + TX;

[0618] A plant activator selected from the group consisting of acibenzolar (6) + TX, acibenzolar-S-methyl (6) + TX, probenazole (658) + TX, and Reynoutria sachalinensis extract (alias) (720) + TX;

[0619] Rodenticide, the rodenticide being selected from the group consisting of: 2-isovalerylindan-1,3-dione (IUPAC name) (1246) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, α-chlorohydrin [CCN] + TX, aluminum phosphide (640) + TX, antoquinol (880) + TX, arsenic trioxide (882) + TX, barium carbonate (891) + TX, dithiocarbamide (912) + TX, brodifacoum (89) + TX, bromadiolone (including α-bromadiolone) + TX, bromodiol (92) + TX, calcium cyanide (444) + TX, chloralose (127) + TX, chlordiol (140) + TX, cholecalciferol (alias) (850) + TX, chlordiol (1004) + TX, chlordiol (1005) + TX, chlordiol (175) + TX, chlordiol (1009) + TX, bromodiol (246) + TX, thiazolin (249) + TX, difacoum (273) + TX, calciferol (301) + TX, Fludioxaline (357) + TX, fluoroacetamide (379) + TX, fludioxaline (1183) + TX, fludioxaline hydrochloride (1183) + TX, γ-HCH (430) + TX, HCH (430) + TX, hydrogen cyanide (444) + TX, iodomethane (IUPAC name) (542) + TX, lindane (430) + TX, magnesium phosphide (IUPAC name) (640) + TX, methyl bromide (537) + TX, fosfomycin (1318) + TX, fosfomycin (133 6) + TX, phosphine (IUPAC name) (640) + TX, phosphorus [CCN] + TX, warfarin (1341) + TX, potassium arsenite [CCN] + TX, warfarin (1371) + TX, scilla glycoside (1390) + TX, sodium arsenite [CCN] + TX, sodium cyanide (444) + TX, sodium fluoroacetate (735) + TX, strychnine (745) + TX, thallium sulfate [CCN] + TX, warfarin (851) + TX, and zinc phosphide (640) + TX;

[0620] A synergist selected from the group consisting of: 2-(2-butoxyethoxy)ethyl piperonate (IUPAC name) (934) + TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (IUPAC name) (903) + TX, farnesol with nerolidol (alias) (324) + TX, MB-599 (research code) (498) + TX, MGK 264 (research code) (296) + TX, piperonyl butoxide butoxide)(649)+TX, piprotal(1343)+TX, propylisomer(1358)+TX, S421(research code)(724)+TX, sesamex(1393)+TX, sesasmolin(1394)+TX and sulfoxide(1406)+TX;

[0621] Animal repellents selected from the group consisting of anthraquinone (32) + TX, chloralose (127) + TX, copper cyclohexane [CCN] + TX, copper oxychloride (171) + TX, diazinon (227) + TX, dicyclopentadiene (chemical name) (1069) + TX, guazatine (422) + TX, guazatine acetate (422) + TX, methiocarb (530) + TX, pyridin-4-amine (IUPAC name) (23) + TX, salamine (804) + TX, trimethacarb (840) + TX, zinc cyclohexane [CCN] + TX, and ziram (856) + TX;

[0622] Virucidal agents selected from the group consisting of: imipenem (alternative name) [CCN] and ribavirin (alternative name) [CCN] + TX;

[0623] A wound protection agent selected from the group consisting of mercuric oxide (512) + TX, octhilinone (590) + TX and thiophanate-methyl (802) + TX;

[0624] Selected from the following biologically active substances: 1,1-bis(4-chloro-phenyl)-2-ethoxyethanol+TX, 2,4-dichlorophenylbenzenesulfonate+TX, 2-fluoro-N-methyl-N-1-naphthylacetamide+TX, 4-chlorodiphenyl sulfone+TX, acetofenapyr+TX, aldisulfonyl+TX, sagofoate+TX, fomanphos+TX, amitriptyline+TX, amitriptyline hydrogen oxalate+TX, amitraz+TX, cypermethrin+TX, arsenic trioxide+TX, azobenzene+TX, azophos+TX, benomyl+TX, benoxafos+TX, benzyl benzoate+TX, bixafenthion+TX, bromethrin+TX, bromofenthion+TX , bromophos + TX, bromopyralid + TX, buprofezin + TX, butacarb + TX, butacarb + TX, butylpyridaben + TX, calcium polysulfide + TX, octachlorocamphene + TX, chlormethoxam + TX, trithion + TX, cypermethrin + TX, cypermethrin + TX, cypermethrin + TX, cypermethrin hydrochloride + TX, chlormequat + TX, cypermethrin + TX, dimethoate + TX, ethyl cypermethrin + TX, cypermethrin + TX, cypermethrin + TX, propyl cypermethrin + TX, cypermethrin + TX, cypermethrin I + TX, cypermethrin II + TX, cypermethrin + TX, closantel + TX, coumaphos + TX, crotamiton + TX, baclofos + T X, thiophanate + TX, chlorfenapyr + TX, DCPM + TX, DDT + TX, dinafop + TX, dinafop-O + TX, dinafop-S + TX, demeton-methyl + TX, demeton-O + TX, demeton-O-methyl + TX, demeton-S + TX, demeton-S-methyl + TX, demeton-S-methyl + TX, demeton-S-methyl + TX, demeton-S-methyl + TX, chlorfenapyr + TX, dichlorvos ... TX, anthelmintic+TX, nitropentyl+TX, nitrosyl acaricide+TX, nitrobutyl+TX, dithiophos+TX, sulfodiphenyl+TX, disulfiram+TX, DNOC+TX, dofenapyn+TX, doramectin+TX, fenoxaphos+TX, eprinomectin+TX, thiophos+TX, ethiprole+TX, anti-mite+TX, fenbutatin+TX, fenthiocarb+TX, tebufenpyrad+TX, fenpyrad+TX, fenthiocarb+TX, fenpyrad+TX, fenthiocarb+TX, fentrifanil+TX, fluazifop+TX, flufenoxuron+TX, diflubenzuron+TX, fluazifop+TX, FMC 1137+TX, fenvalerate+TX, fenvalerate hydrochloride+TX, formparanate+TX, γ-HCH+TX, chlorpyrifos+TX, benzylfenthion+TX, hexadecyl cyclopropanecarboxylate+TX, isocarbophos+TX,Jasmonate I + TX, Jasmonate II + TX, Iodonate + TX, Lindane + TX, Propionyl + TX, Methiophos + TX, Dithiophos + TX, Methylthiophene + TX, Acarb + TX, Methyl bromide + TX, Metolcarb + TX, Ziclofos + TX, Milbemycin + TX, Propionyl + TX, Monocrotophos + TX, Maoguo + TX, Moxidectin + TX, Naled + TX, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6-iodo-3-pyridyl)methoxy]pyridazin-3-one + TX, Flufenacet + TX, Nikcomycin + TX, Penbufencarb + TX, Penbufencarb 1:1 zinc chloride complex + TX, Omethoate + TX, Isopropylphos + TX, Sulfonatophos + TX, PP' -DDT+TX, parathion+TX, permethrin+TX, fenthion+TX, phosalone+TX, thiophanate+TX, phosphamidon+TX, polychloroterpenes+TX, polynactins+TX, prochlorperanils+TX, cypermethrin+TX, propoxur+TX, ethidium+TX, pyrethrin+TX, pyrethrin I+TX, pyrethrin II+TX, pyrethrin+TX, pyrimethoxam+TX, quinalphos+TX, quintiofos+TX, R-1492+TX, glyphosate+TX, rotenone+TX, octamethrin+TX, clofos Dan + TX, selamectin + TX, thiophos + TX, SSI-121 + TX, sufilam + TX, sulfluramid + TX, sulfotep + TX, sulfur + TX, flumethrin + TX, τ-fluvalinate + TX, TEPP + TX, terbucarb + TX, tetrachlorvinphos + TX, thiafenox + TX, pyrimidine + TX, long-lasting cypermethrin + TX, methyl benzyl sulfate + TX, chlorpyrifos + TX, thiamethoxam + TX, thiamethoxam + TX, thiamethoxam + TX, thiamethoxam + TX, triazophos + TX, triazuron + TX, triclopyralid + TX, triamcin + TX, aphidoxam + TX, vaniliprole + TX, benzathine (bet Hoxazin) + TX, copper dioctanoate + TX, copper sulfate + TX, cybutryne + TX, dichloronaphthoquinone + TX, dichlorophen + TX, endoxan + TX, triphenyltin + TX, slaked lime + TX, sodium mancozeb + TX, quinone + TX, quinone + TX, simazine + TX, triphenyltin acetate + TX, triphenyltin hydroxide + TX, fusulin + TX, piperazine + TX, thiophanate + TX, chloralose + TX, fenthion + TX, pyridin-4-amine + TX, strychnine + TX, 1-hydroxy-1H-pyridine-2-thione + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide + TX, 8-hydroxyquinoline sulfate + TX, bronopol + TX, copper hydroxide + TX,Cresol + TX, dipyrithione + TX, dodixin + TX, sodium disulfate + TX, formaldehyde + TX, mercurophen + TX, kasugamycin + TX, kasugamycin hydrochloride hydrate + TX, nickel bis(dimethyldithiocarbamate) + TX, trichloromethylpyridine + TX, octhiothione + TX, oxolinic acid + TX, oxytetracycline + TX, potassium hydroxyquinoline sulfate + TX, thiabendazole + TX, streptomycin + TX, streptomycin sesquisulfate + TX, chlorothiazol + TX, thimerosal + TX, cotton brown-banded tormenter GV + TX, Agrobacterium radiobacterium + TX, Amblyseius spp. + TX, celery budworm NPV + TX, Anagrus atomus + TX, short-spurred aphid wasp + TX, cotton aphid parasitoid (Aphidius colemani) + TX, aphid midge (Aphidoletes aphidimyza+TX, Spodoptera alfalfa NPV+TX, Bacillus sphaericus Neide+TX, Beauveria brongniartii+TX, Chrysoperla carnea+TX, Cryptolaemus montrouzieri+TX, Codling moth GV+TX, Dacnusa sibirica+TX, Diglyphus isaea+TX, Eretmocerus eremicus+TX, Heterorhabditis bacteriophora and H. megidis+TX, Hippodamia convergens+TX, Leptomastix dactylopii)+TX, Macrolophus caliginosus+TX, cabbage looper NPV+TX, Metaphycus helvolus+TX, Metarhizium anisopliae var. acridum+TX, Metarhizium anisopliae var. anisopliae+TX, Neodiprion sertifer NPV and N. lecontei NPV+TX, species of the genus Microsporum+TX, Paecilomyces fumosorum+TX, Phytoseiulus persimilis+TX,Steinernema bibionis + TX, Steinernema carpocapsae + TX, Steinernema argentea + TX, Steinernema maglaseri + TX, Steinernema riobrave + TX, Steinernema riobravis + TX, Steinernema scapterisci + TX, Steinernema species + TX, Trichogramma species + TX, Typhlodromus occidentalis) + TX, Verticillium lecanii + TX, apholophosphine (apholate) + TX, bis(aziridine) methylaminophosphine sulfide (bisazir) + TX, busulfan + TX, dimatif + TX, hemelamine (hemel) + TX, hempa + TX, metepa + TX, methiotepa + TX, methyl apholophosphine + T X, infertile dapoxetine + TX, flubendiamide + TX, thiamethoxam + TX, thiamethoxam + TX, trothamide + TX, urethane imine + TX, (E)-dec-5-en-1-yl acetate and (E)-dec-5-en-1-ol + TX, (E)-tridec-4-en-1-yl acetate + TX, (E)-6-methylhept-2-en-4-ol + TX, (E,Z)-tetradec-4,10-dien-1-yl acetate + TX, (Z)-dodec-7-en-1-yl acetate + TX, (Z)-hexadecane 11-enal + TX, (Z)-hexadec-11-en-1-yl acetate + TX, (Z)-hexadec-13-en-11-yn-1-yl acetate + TX, (Z)-eicos-13-en-10-one + TX, (Z)-tetradec-7-en-1-al + TX, (Z)-tetradec-9-en-1-ol + TX, (Z)-tetradec-9-en-1-yl acetate + TX, (7E,9Z)-dodec-7,9-dien-1-yl acetate + TX, (9Z,11E)-tetradec-9, 11-dien-1-yl acetate + TX, (9Z,12E)-tetradec-9,12-dien-1-yl acetate + TX, 14-methyloctadec-1-ene + TX, 4-methylnon-5-ol and 4-methylnon-5-one + TX, α-polystyrene + TX, western pine beetle gathering pheromone + TX, dodecadienol + TX, caldoxime + TX, tardigrade + TX, oxirane + TX, epoxynonadecane + TX, dodec-8-en-1-yl acetate + TX, dodec-9-en-1-yl acetate + TX, dodec-8 + TX,10-dien-1-yl acetate + TX, domi attractant + TX, 4-methyloctanoic acid ethyl ester + TX, eugenol + TX, southern pine beetle gathering pheromone + TX, trapping ene mixture + TX, trapping ene mixture I + TX, trapping ene mixture II + TX, trapping ene mixture III + TX, trapping ene mixture IV + TX, hexane attractant + TX, tooth beetle dienol + TX, small beetle dienol + TX, scarab sex attractant + TX, trimethyldioxytricyclononane + TX, moth sex attractant + TX, cabbage looper sex attractant + TX, trapping ester + TX, (3E,5Z)-tetradec-3,5-dienoic acid (megatomoic acid)+TX, entophore+TX, entophore+TX, octadec-2,13-dien-1-yl acetate+TX, octadec-3,13-dien-1-yl acetate+TX, Heconbi+TX, coconut rhinoceros beetle aggregation pheromone+TX, Feilekang+TX, insect trap+TX, banana bulb weevil attractant+TX, fungivorous methyl entol+TX, tetradec-11-en-1-yl acetate+TX, Mediterranean fruit fly attractant+TX, Mediterranean fruit fly attractant A+TX, Mediterranean fruit fly attractant B1+TX, Mediterranean fruit fly attractant B2 +TX, Mediterranean fruit fly attractant C+TX, trunc-call+TX, 2-(octylthio)ethanol+TX, diethylaminobenzoate+TX, butoxy(polypropylene glycol)+TX, dibutyl adipate+TX, dibutyl phthalate+TX, dibutyl succinate+TX, DEET+TX, mosquito repellent+TX, dimethyl phthalate+TX, ethyl hexanediol+TX, hexylurea+TX, mequindine+TX, methyl neodecylamide+TX, oxamate+TX, picaridin+TX, 1-dichloro-1-nitroethane+TX, 1,1-dichloro- 2,2-bis(4-ethylphenyl)ethane + TX, 1,2-dichloropropane and 1,3-dichloropropylene + TX, 1-bromo-2-chloroethane + TX, 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate + TX, 2,2-dichlorovinyl 2-ethylsulfinylethyl methyl phosphate + TX, 2-(1,3-dithiolan-2-yl)phenyl dimethylcarbamate + TX, 2-(2-butoxyethoxy)ethyl thiocyanate + TX, 2-(4,5-dimethyl-1,3-dioxolan-2-yl)phenylmethylamino Formate + TX, 2-(4-chloro-3,5-xylyloxy)ethanol + TX, 2-chlorovinyl diethyl phosphate + TX, 2-imidazolidinone + TX, 2-isovaleryl indan-1,3-dione + TX, 2-methyl (prop-2-ynyl) aminophenyl methylcarbamate + TX, 2-thiocyanatoethyl laurate + TX, 3-bromo-1-chloroprop-1-ene + TX, 3-methyl-1-phenylpyrazol-5-yl dimethylcarbamate + TX, 4-methyl (prop-2-ynyl) amino-3,5-xylyl methylcarbamate + TX,5,5-Dimethyl-3-oxocyclohex-1-enyl dimethylcarbamate + TX, acethion + TX, acrylonitrile + TX, aldrin + TX, alloamicin + TX, chlorfenvinphos + TX, α-deceprin + TX, aluminum phosphide + TX, chlorfenvinphos + TX, neonicotinoids + TX, ethyl methidathion + TX, methyl pyriphos + TX, Bacillus thuringiensis δ-endotoxin + TX, barium hexafluorosilicate + TX, barium polysulfide + TX, cypermethrin + TX, Bayer 22 / 190 + TX, Bayer 22408 + TX, β-cyfluthrin + TX, β-cypermethrin + TX, pentothrin + TX, biopermethrin + TX, bis(2-chloroethyl) ether + TX, borax + T X, bromophenazone + TX, bromo-DDT + TX, chlorpyrifos + TX, cypermethrin + TX, temirphos + TX, butyl phosphate + TX, calcium arsenate + TX, calcium cyanide + TX, carbon disulfide + TX, carbon tetrachloride + TX, badan hydrochloride + TX, servadine + TX, bornyl + TX, chlordane + TX, chlordecone + TX, chloroform + TX, chloropicrin + TX, chloranisole + TX, chlorpyrifos + TX, cis-resmethrin + TX, cis-resmethrin + TX, cypermethrin + TX, copper acetylarensite + TX, copper arsenate + TX, copper oleate + TX, cypermethrin + TX, cryolite + TX, CS 708+TX, benzonitrile+TX, cypermethrin+TX, cypermethrin+TX, cypermethrin+TX, d-cypermethrin+TX, DAEP+TX, dazomethon+TX, demethylcarbofuran+TX, chloranil+TX, isochlorphos+TX, chloranil+TX, mixed toluene carbamate (dicresyl)+TX, cypermethrin+TX, dieldrin+TX, diethyl 5-methylpyrazol-3-yl phosphate+TX, thiophene+TX, tetrafluthrin+TX, demacarb+TX, pyrethrin+TX, methylchlorfenapyr+TX, difenocarb+TX, propanol+TX, pentotropol+TX, dinoseb+TX, fenpropathrin+TX, vegetable fruit phosphorus+TX, thiopyraphos+TX, DSP+TX, ecdysterone+TX, EI 1642+TX, EMPC+TX, EPBP+TX, etaphos+TX, ethiobencarb+TX, ethyl formate+TX, ethylene dibromide+TX, ethylene dichloride+TX, ethylene oxide+TX, EXD+TX, pyraclostrobin+TX, ethiobencarb+TX, fenitrothion+TX, pyrimidine+TX, fenthion+TX, ethylfenthion+TX, flucloroxadimethoxine+TX, butylfenthion+TX, phosphonium phosphate+TX, butylcyclothion+TX, furathiocarb+TX, pyrethroid+TX, biguanide salt+TX, biguanide acetate+TX, sodium tetrathiocarbonate+TX, benzyl methoxychlor+TX, HCH+TX, HEOD+TX, heptachlor+TX, cypermethrin+TX, HHDN+TX, hydrogen cyanide+TX,Quinolinecarb + TX, IPSP + TX, chlorfenapyr + TX, carbofuran + TX, isodrin + TX, isofenphos + TX, transplanting agent + TX, rice blast + TX, isoxathiophos + TX, juvenile hormone I + TX, juvenile hormone II + TX, juvenile hormone III + TX, chlorfenapyr + TX, methoprene + TX, lead arsenate + TX, bromofenphos + TX, pyralid + TX, thiathiophene + TX, m-isopropyl methylcarbamate + TX, magnesium phosphide + TX, phosphorus azide + TX, methyl azoxystrobin + TX, thiamethoxam + TX, mercurous chloride + TX, methyl sulfoxide + TX, metamifene + TX, metamifene potassium + TX, metamifene sodium + TX, methylsulfonyl fluoride + TX, butenamidophos + TX, methoprene + TX, methoxychlor + TX, methoxychlor T+TX, methyl isothiocyanate+TX, methyl chloroform+TX, dichloromethane+TX, oxadiazine+TX, mirex+TX, napeptidephos+TX, naphthalene+TX, NC-170+TX, nicotine+TX, nicotine sulfate+TX, nithiazine+TX, pronicotine+TX, O-5-dichloro-4-iodophenyl O-ethylethylphosphonothioate+TX, O,O-diethyl O-4-methyl-2-oxo-2H-benzopyran-7-ylphosphonothioate+TX, O,O-diethyl O-6-methyl-2-propylpyrimidin-4-ylphosphonothioate+TX, O,O,O',O'-tetrapropyl dithiopyrophosphate+TX, oleic acid+TX, p-dichlorobenzene+TX, methyl parathion+TX, pentachlorophenol+TX, pentachlorophenyl laurate+TX, PH 60-38+TX, fenthion+TX, parachlorothion+TX, phosphine+TX, methyl phoxim+TX, methamidophos+TX, polychlorinated dicyclopentadiene isomers+TX, potassium arsenite+TX, potassium thiocyanate+TX, precocious phosphine I+TX, precocious phosphine II+TX, precocious phosphine III+TX, amidothrin+TX, fluthrin+TX, fenvalerate+TX, prothiophos+TX, pyraclostrobin+TX, anti-pyrethroid+TX, quassia extract+TX, quinalphos-methyl+TX, fenvalerate+TX, iodophos+TX, resmethrin+TX, rotenone+TX, thiamethoxam+TX, ryanodine+TX, saba Veratrum (sabadilla) + TX, octamethrin + TX, clomardan + TX, SI-0009 + TX, thiamethoxam + TX, sodium arsenite + TX, sodium cyanide + TX, sodium fluoride + TX, sodium hexafluorosilicate + TX, sodium pentachlorophenol + TX, sodium selenate + TX, sodium thiocyanate + TX, sulcofuron + TX, sulcofuron sodium salt + TX, sulfuryl fluoride + TX, thiopromone + TX, tar + TX, thiabendazim + TX, TDE + TX, butylpyrimidinphos + TX, dimethophos + TX, cypermethrin + TX, tetrachloroethane + TX, thiochlorvos + TX, cypermethrin + TX, cypermethrin oxalate + TX, cypermethrin + TX,Cypermethrin + TX, cypermethrin sodium + TX, tralomethrin + TX, permethrin + TX, triazolam + TX, isothiocarb-3 + TX, chlorpyrifos + TX, thiamethoxam + TX, trifluoxetine + TX, chlorpyrifos-butyl + TX, methoprene + TX, veratridine + TX, veratridine + TX, XMC + TX, ζ-cypermethrin + TX, zinc phosphide + TX, tolfenphos + TX, cypermethrin + TX, tetrafluthrin + TX, bis(tributyltin) oxide + TX, bromoacetamide + TX, ferric phosphate + TX, niclosamide-ethanolamine + TX , tributyltin oxide + TX, pyromorphine + TX, snail killer + TX, 1,2-dibromo-3-chloropropane + TX, 1,3-dichloropropylene + TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide + TX, 3-(4-chlorophenyl)-5-methylrhodanine + TX, 5-methyl-6-thioxo-1,3,5-thiadiazin-3-yl acetic acid + TX, 6-isopentenylaminopurine + TX, fluorophenyladenine + TX, phenylchlorothiazide + TX, cytokinin + TX, DCIP + TX, furfural + TX, isoamidophos + TX, kinetin + T X, verrucous myrtle composition + TX, tetrachlorothiophene + TX, xylenol + TX, zeatin + TX, potassium ethyl xanthate + TX, acibenzolar + TX, acibenzolar-S-methyl + TX, giant knotweed extract + TX, α-chlorohydrin + TX, antu + TX, barium carbonate + TX, bifenthionine + TX, brodifacoum + TX, brodifacoum + TX, brofenthionine + TX, chlorfenthionine + TX, cholecalciferol + TX, chlorfenapyr ... Warfarin + TX, calciferol + TX, fludioxaline + TX, fluoroacetamide + TX, fludioxaline + TX, fludioxaline hydrochloride + TX, warfarin + TX, fosfomycin + TX, phosphorus + TX, warfarin + TX, warfarin + TX, scillarin glycoside + TX, sodium fluoroacetate + TX, thallium sulfate + TX, warfarin + TX, 2-(2-butoxyethoxy)ethyl piperonate + TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone + TX, farnesol with nerolidol + TX, synergistic alkynyl ether + TX, MGK 264+TX, piperonyl butoxide+TX, synergistic aldehyde+TX, propyl isomer+TX, S421+TX, synergistic powder+TX, sesame linolenic acid+TX, sulfoxide+TX, anthraquinone+TX, copper naphthenate+TX, copper oxychloride+TX, dicyclopentadiene+TX, salamine+TX, zinc naphthenate+TX, ziram+TX, imanin+TX, ribavirin+TX, chloroindole hydrazide+TX, mercuric oxide+TX, thiophanate-methyl+TX, azaconazole+TX, bifenthiazolin+TX, fuconazole+TX, cyproconazole+TX, difenoconazole+TX, diniconazole+TX, fluoxepiconazole+TX, fenbuconazole+TX, fluquinconazole+TX, flusilazole+TX, flutriafol+TX,Furoxamethylenetetramine + TX, hexaconazole + TX, imazalil + TX, imidazole + TX, piclonil + TX, metconazole + TX, myclobutrazol + TX, paclobutrazol + TX, blastifungin + TX, penconazole + TX, prothioconazole + TX, pyraclostrobin + TX, prochloraz + TX, propiconazole + TX, pyraclostrobin + TX, silyfenazole + TX, tebuconazole + TX, fluconazole + TX, triadimefon + TX, triadimenol + TX, triflumizole + TX, trichlorfon + TX, pyrimidinol + TX, chlorfenapyr + TX, flufenapyr + TX, pyrimidinol + TX, pyrimidinol + TX, pyrimidinol + TX, pyrimidinol sulfonate + TX, mefenadine + TX, pyrimidinol + TX, dodecamorph + TX, fenpropidin + TX, fenpropimorph + TX, spiroxazoline + TX, tridecamorph + TX, cyprodinil +TX, myclobutanil +TX, myclobutanil +TX, fenpiclonil +TX, fludioxonil +TX, benalaxyl +TX, furalaxyl +TX, metalaxyl +TX, R-metalaxyl +TX, furamide +TX, oxadixyl +TX, carbendazim +TX, imidacloprid +TX, maisinin +TX, thiabendazole +TX, acetobacter +TX, sclerotinol +TX, formicyl +TX, procymidone +TX, vinclozolin +TX, boscalid +TX, carboxin +TX, furamide +TX, flutolanil +TX, mefenamic acid +TX, oxycarboxin +TX, penthiopyrad +TX, thiofuran +TX, dodine +TX, biguanide +TX, azoxystrobin +TX, kystrobin +TX, enestrobin +TX, enestrobin +TX, flutolanil +TX Bacillus thiocarb + TX, fluoxastrobin + TX, kresoxim-methyl + TX, fenoxystrobin + TX, trifloxystrobin + TX, orysastrobin + TX, picoxystrobin + TX, pyraclostrobin + TX, pyraclostrobin + TX, ferbam + TX, mancozeb + TX, maneb + ​​TX, maneb + ​​TX, maneb + ​​TX, maneb + ​​TX, captafol + TX, captan + TX, pyraclostrobin + TX, folpet + TX, tolylfluanid + TX, Bordeaux mixture + TX, copper oxide + TX, mancozeb + TX, quinoline copper + TX, phthalostrobin + TX, kefusan + TX, isoblastin + TX, chlorpyrifos + TX, tolclofos-methyl + TX, captafol + TX, benzathiapiprolin + TX, blasticidin-S + T X, Dimaosan + TX, Chlorothalonil + TX, Cymoxanil + TX, Triflupyralid + TX, Dichlorocyanamide + TX, Dapoxetine + TX, Chlornithine + TX, Dithiocarb + TX, Dimethomorph + TX, Flumorph + TX, Dithianon + TX, Ethiazolin + TX, Dimethomorph + TX, Famoxadone + TX, Famizone + TX, Padoxamide + TX, Feloconazole + TX, Fluazinam + TX, Fluopyram + TX, Fluopyram + TX, Fluopyram + TX, Fluopyram + TX, Fluopyram + TX, Fenpyram + TX, Fosetyl-Aluminum + TX, Hydrazol + TX, Propineb + ​​TX, Cypermethrin + TX, Sulfonamide + TX, Mefenpyrad + TX, Pencycuron + TX, Phthalides + TX,Polyoxin + TX, propamocarb + TX, pyraclostrobin + TX, iodoquinolone + TX, pyraclostrobin + TX, quinoxyfen + TX, pentachloronitrobenzene + TX, thiazolin + TX, imidazolin + TX, tricyclazole + TX, triazolin + TX, validamycin + TX, valosin + TX, zoxamide + TX, dimethomorph + TX, fluphenazine + TX, pyraclostrobin + TX, fluopicolide + TX, benzophenone + TX, fluopicolide + TX, benzophenone + TX, fluopicolide hydroxylamine + TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3',4',5'-trifluoro-biphenyl-2-yl)-amide + TX, isopropyram + TX, isothiopyram + TX, thiazolin + TX, 6-ethyl- 5,7-dioxo-pyrrolo[4,5][1,4]dithiino[1,2-c]isothiazole-3-carbonitrile + TX, 2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-pyridazine-3-carbonitrile + TX, (R)-3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide + TX, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazol-3-amine + TX, 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3 -Dimethyl-1H-pyrazol-5-amine + TX, flufenoxam + TX, Jiaxiangjunzhi + TX, chlorphenamide + TX, dichlorothiazide + TX, Mandespin + TX, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-1-yl)quinolone + TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolinyl)oxy]phenyl]propan-2-ol + TX, thiabendazim + TX, N-[6-[[[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridinyl]carbamic acid tert-butyl ester + TX, flufenoxam + TX, indopoxycillin + TX, carbamate fungicides (trolp rocarb) + TX, clofoconazole + TX, isotrifluanidazole + TX, 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine + TX, N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine + TX, [2-[3-[2-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidinyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3-chloro-phenyl] methanesulfonate + TX,N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridinyl]carbamic acid but-3-ynyl ester + TX, N-[[5-[4-(2,4-dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamic acid methyl ester + TX, 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl)pyridazine + TX, flubendiamide + TX, 3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide + TX, 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one + TX, 1-methyl-4-[3-methyl 1-[[2-methyl-4-(3,4,5-trimethylpyrazol-1-yl)phenoxy]methyl]phenyl]tetrazol-5-one+TX, amopyraclostrobin+TX, pyraclostrobin+TX, indazolesulfaquinamide+TX, fluopicolide+TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamine+TX, diflupyraclostrobin+TX, benzylpyrimide+TX, pyrimidinesulfaquinamide+TX, isobutylethoxyquinoline+TX, isopropylthioquinoline+TX, fluopicolide+TX, isopropylthioquinoline+TX, 1-[[4-[[2-(trifluoromethyl)-1,3-dioxolane-2-yl]methoxy]phenyl]methyl]pyrazole-3-carboxylic acid ethyl ester+TX (can be made from WO 2020 / 056090), 1-[[4-[(Z)-2-ethoxy-3,3,3-trifluoro-prop-1-enyloxy]phenyl]methyl]pyrazole-3-carboxylic acid ethyl ester + TX (can be prepared by the method described in WO 2020 / 056090), N-[[4-[1-(4-cyclopropyl-2,6-difluoro-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamic acid methyl ester + TX (can be prepared by the method described in WO 2020 / 097012), N-[[4-[1-(2,6-difluoro-4-isopropyl-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamic acid methyl ester + TX (can be prepared by the method described in WO2020 / 097012), 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide + TX (can be prepared by the method described in WO 2020 / 109391), 6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2-difluoro-ethyl]-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-carboxamide + TX (can be prepared by the method described in WO 2020 / 109391),6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(3,4-dimethylphenyl)-2,2-difluoro-ethyl]-5-methyl-pyridazine-4-carboxamide + TX (can be prepared by the method described in WO 2020 / 109391), N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX, benzathiostrobin + TX, cyproconazole + TX, 5-amino-1,3,4-thiadiazole-2-thiol zinc salt (2:1) + TX, fluopyram + TX, flufenoxadiazam + TX, fluthiazolinone + TX X, fluopyram + TX, pyrapropoyne + TX, picarbutrazox + TX, 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide + TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, me tyltetraprole+TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide+TX, α-(1,1-dimethylethyl)-α-[4'-(trifluoromethoxy)[1,1'-diphenyl]-4-yl]-5-pyrimidinemethanol+TX, fluoxapiprolin+TX, enoxastrobin+TX, (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoic acid methyl ester+TX, ( Z) -3-methoxy-2- [2-methyl-5- (4-propyltriazol-2-yl) phenoxy] prop-2-enoic acid methyl ester + TX, (Z) -2- [5- (3-isopropylpyrazol-1-yl) -2-methyl-phenoxy] -3-methoxy-prop-2-enoic acid methyl ester + TX, (Z) -3-methoxy-2- [2-methyl-5- (3-propylpyrazol-1-yl) phenoxy] prop-2-enoic acid methyl ester + TX, (Z) -3-methoxy-2- [2-methyl-5- [3- (trifluoromethyl) pyrazol-1-yl] phenoxy] prop-2-enoic acid methyl ester + TX (these compounds can be prepared by the method described in WO 2020 / 079111), (Z) -2- (5-cyclohexyl-2-methyl-phenoxy) -3-methoxy-prop-2-enoic acid methyl ester + TX,(Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoic acid methyl ester + TX (these compounds can be prepared by the method described in WO 2020 / 193387), 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-sulfanyl-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy] Benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, anti-invertase + TX, syringostyrin + TX, zhongshengmycin + TX, thiophanate-methyl + TX, thiazole zinc + TX, amethoxam + TX, isoprofen + TX, succinylpyridin + TX, thiabendazole (amectin) + TX, isoprofen + TX, succinylpyridin (s eboctylamine) + TX; N'-[5-bromo-2-methyl-6-[(1S)-1-methyl-2-propoxy-ethoxy]-3-pyridinyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridinyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridinyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared by WO 2015 / 155075); N'-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX (this compound can be prepared by the method described in IPCOM000249876D); N-isopropyl-N'-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenyl-ethyl)phenyl]-N-methyl-formamidine + TX, N'-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared by the method described in WO 2018 / 228896); N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine + TX,N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)tetrahydrofuran-2-yl]phenyl]-N-methyl-formamidine + TX (these compounds can be prepared by the method described in WO 2019 / 110427); N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]- 8-Fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3- Formamide + TX, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + TX, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + T X, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + TX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + TX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + TX (these compounds can be made from WO 2017 / 153380); 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX, 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline+TX, 4,4-difluoro-3,3-dimethyl -1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 4,4-difluoro-3,3-dimethyl-1-(7-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX (these compounds can be prepared by the method described in WO 2017 / 025510); 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX,1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX, 6-chloro-4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline+TX, 4,4-difluoro-1-(5-fluoro-4-methyl-benzimidazol-1-yl)-3,3-dimethyl-isoquinoline+TX, 3-(4,4-difluoro-3,3-dimethyl-1-isoquinolyl)-7,8-dihydro-6H-cyclopenta[e]benzimidazole+TX (these compounds can be prepared by WO 2016 / 156085); N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide+TX, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide+TX, N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide+TX, )-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide+TX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 3-ethyl-1-methoxy-1-[[4-[ 5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide+TX, 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, 5,5-dimethyl-2-[[4-[5 -(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylic acid ethyl ester+TX, N,N-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1,2,4-triazol-3-amine+TX. The compounds in this paragraph can be prepared by WO 2017 / 055473, WO 2017 / 055469,Prepared by the method described in WO 2017 / 093348 and WO 2017 / 118689; 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound can be prepared by the method described in WO 2017 / 029179); 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound can be prepared by the method described in WO 2017 / 029179); 3-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile+TX (this compound can be prepared by the method described in WO 2016 / 156290); 3-[2-(1-chlorocyclopropyl)-3-(3-chloro-2-fluoro-phenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile + TX (this compound can be prepared by the method described in WO 2016 / 156290); 2-amino-6-methyl-pyridine-3-carboxylic acid (4-phenoxyphenyl) methyl ester + TX (this compound can be prepared by the method described in WO 2014 / 006945); 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']bipyrrole-1,3,5,7(2H,6H)-tetraone + TX (this compound can be prepared by the method described in WO 2011 / 138281); N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX; N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX; (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamine+TX (this compound can be prepared by WO 2018 / 153707); N'-(2-chloro-5-methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine + TX; N'-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N-methyl-formamidine + TX (this compound can be prepared by the method described in WO2016 / 202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX (this compound can be prepared by the method described in WO 2014 / 095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone + TX,(3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone + TX (these compounds can be prepared by the method described in WO 2017 / 220485); 2-oxo-N-propyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX (this compound can be prepared by the method described in WO 2018 / 065414); 1-[[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]pyrazole-4-carboxylic acid ethyl ester + TX (this compound can be prepared by the method described in WO2018 / 158365); 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX, N-[(E) -methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N-[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N-[N-methoxy-C-methyl-carbonimido]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX (these compounds can be prepared by the method described in WO 2018 / 202428);

[0625] Microbial agents, including: Acinetobacter lwoffii + TX, Acremonium alternifolium + TX + TX, Acremonium cephalosporium + TX + TX, Acremonium diospyri + TX, Acremonium obclavatum + TX, and AdoxGV +TX, Agrobacterium radioactive strain K84 +TX, Alternaria interspersed +TX, Alternaria cassiae +TX, Alternaria destruens +TX, Parasitoid spores +TX, Aspergillus flavus AF36 +TX, Aspergillus flavus NRRL 21882 +TX, Aspergillus species +TX, Aureobasidium +TX, Azospirillum spp. ( TAZO )+TX, nitrogen-fixing bacteria+TX, Azotobacter chroocuccum +TX, nitrogen-fixing bacteria cysts (BionaturalBlooming )

[0626] +TX, Bacillus amyloliquefaciens +TX, Bacillus cereus +TX, Bacillus chitinosporus strain CM-1 +TX, Bacillus chitinosporus strain AQ746 +TX, Bacillus licheniformis strain HB-2 (e.g. Biostart TM , the previous )+TX, Bacillus licheniformis strain 3086 ( Green )+TX, Bacillus circulans+TX, Bacillus firmus ( BioNem- )+TX, Bacillus firmus strain I-1582+TX, Bacillus macerans+TX, Bacillus marismortui+TX, Bacillus megaterium+TX, Bacillus mycoides strain AQ726+TX, Milky Spore )+TX, Bacillus pumilus species+TX, Bacillus pumilus strain GB34 (Yield )+TX, Bacillus pumilus strain AQ717+TX, Bacillus pumilus strain QST 2808( Ballad )+TX, Bacillus spahericus +TX, Bacillus sp. +TX, Bacillus sp. strain AQ175 +TX, Bacillus sp. strain AQ177 +TX, Bacillus sp. strain AQ178 +TX, Bacillus subtilis strain QST 713 +TX, Bacillus subtilis strain QST714 +TX, Bacillus subtilis strain AQ153+TX, Bacillus subtilis strain AQ743+TX, Bacillus subtilis strain QST3002+TX, Bacillus subtilis strain QST3004+TX, Bacillus subtilis variant strain FZB24 +TX, Bacillus thuringiensis Cry 2Ae+TX, Bacillus thuringiensis Cry1Ab+TX, Bacillus thuringiensis subsp. Aizawawai GC 91 +TX, Bacillus thuringiensis israelensis +TX, Bacillus thuringiensis kurstaki ( Scutella Turilav Dipel )+TX, Bacillus thuringiensis kurstaki BMP 123 +TX, Bacillus thuringiensis subsp. Kurstaki HD-1 +TX, Bacillus thuringiensis strain BD#32+TX, Bacillus thuringiensis strain AQ52+TX, Bacillus thuringiensis var. aizawai +TX, Bacteria species ( X、 )+TX, bacteriophage of Clavipacter michiganensis +TX, +TX, Beauveria bassiana (

[0627] Brocaril )+TX, Beauveria bassiana GHA (Mycotrol Mycotrol )+TX, Beauveria brongniartii ( Schweizer )+TX, Beauveria spp.+TX, Botrytis cineria+TX, Bradyrhizobium japonicum +TX, Brevibacillus brevis +TX, Bacillus thuringiensis tenebrionis +TX, BtBooster+TX, Burkholderia cepacia ( Blue )+TX, Burkholderia gladii+TX, Burkholderia gladioli+TX, Burkholderia species+TX, Canadian thistle fungus (CBH Canadian )+TX, Candida butyri+TX, Candida famata+TX, Candida fructus+TX, Candida glabrata+TX, Candida guilliermondii+TX, Candida melibiosica+TX, Candida oleophila strain O+TX, Candida parapsilosis+TX, Candida pelliculosa+TX, Candida pulcherrima+TX, Candida reukaufii+TX, Candida saitoana +TX, Candida sake +TX, Candida spp. +TX, Candida tenius +TX, Cedecea dravisae +TX, Cellulomonas flavigena +TX, Chaetomium cochliodes +TX, Chaetomium globosum +TX, Chromobacterium subtsugae strain PRAA4-1T +TX, Cladosporium cladosporioides +TX, Cladosporium oxysporum +TX, Cladosporium chlorocephalum +TX, Cladosporium spp. +TX, Cladosporium tenuissimum +TX, Clonostachys rosea +TX, Colletotrichum acutatum +TX, Coniothyrium minitans (Cotans )+TX, Coniothyrium spp.+TX, Cryptococcus albidus +TX, Cryptococcus humicola +TX, Cryptococcus infirmo-miniatus +TX, Cryptococcus laurentii +TX, Cryptophlebialeucotreta granulovirus +TX, Cupriavidus campinensis+TX, Cydia pomonella granulovirus +TX, codling moth granulosis virus ( Plus, Max, Carpovirusine )+TX、Cylindrobasidium laeve +TX, Cylindrocladium +TX, Debaryomyces hansenii +TX, Drechslera hawaiinensis +TX, Enterobacter cloacae +TX, Enterobacteriaceae +TX, Entomophtora virulenta +TX, Epicoccum nigrum +TX, Epicoccum purpurascens +TX, Epicoccum species +TX, Filobasidium floriforme +TX, Fusarium acuminatum +TX, Fusarium chlamydosporum +TX, Fusarium oxysporum ( Biofox )+TX, Fusarium proliferatum+TX, Fusarium spp.+TX, Galactomyces geotrichum+TX, Gliocladium catenulatum +TX, Gliocladium roseum +TX, Gliocladium spp. +TX, Gliocladium virens +TX, Granulovirus +TX, Halobacillus halophilus +TX, Halobacillus litoralis +TX, Halobacillus trueperi +TX, Halomonas spp. +TX, Halomonas subglaciescola +TX, Halovibrio variabilis +TX, Hanseniaspora uvarum +TX, Helicoverpaarmigera nucleopolyhedrovirus +TX, Helicoverpa zea nuclear polyhedrosis virus +TX, Isoflavone-formononetin +TX, Kloeckera apiculata +TX, Kloeckera spp. +TX, Lagenidium giganteum +TX, Lecanicillium longisporum +TX, Lecanicillium muscarium +TX, Lymantria Dispar nucleopolyhedrosis virus +TX, Marinococcus halophilus +TX, Meira geulakonigii +TX, Metarhizium anisopliae +TX, Metarhizium anisopliae (Destruxin )+TX, Metschnikowia fruticola +TX, Maggi Meiqi yeast (Metschnikowiapulcherrima) +TX, (Microdochium dimerum) +TX, Micromonospora coerulea +TX, Microsphaeropsis ochracea +TX, Muscodor albus 620 +TX, Muscodor roseus strain A3-5+TX, Mycorrhizae spp. ( Root )+TX, Myrothecium verrucaria strain AARC-0255 +TX, +TX, Ophiostoma piliferum strain D97 +TX, Paecilomyces farinosus +TX, Paecilomyces fumosoroseus +TX, Paecilomyces linacinus (Biostat )+TX, Paecilomyces lilacinus strain 251 (MeloCon )+TX, Paenibacillus polymyxa+TX, Pantoea agglomerans (BlightBan )+TX, Pantoea spp.+TX, Pasteuria spp. +TX, Pasteuria nishizawae +TX, Penicillium aurantiogriseum +TX, Penicillium billai +TX, Penicillium brevicompactum +TX, Penicillium frequentans +TX, Penicillium griseofulvum +TX, Penicillium purpurogenum +TX, Penicillium spp. +TX, Penicillium viridicatum +TX, Phlebiopsis gigantean +TX, phosphate solubilizing bacteria +TX, Phytophthora cryptogea +TX, Phytophthora palmivora +TX, Pichia anomala +TX, Pichia guilermondii +TX, Pichia membranaefaciens +TX, Pichia onychis +TX, Pichia stipites +TX, Pseudomonas aeruginosa +TX, Pseudomonas aureofasciens (Spot-Less )+TX, Pseudomonas cepacia+TX, Pseudomonas chlororaphis +TX, Pseudomonas corrugate +TX, Pseudomonas fluorescens strain A506 (BlightBan )+TX, Pseudomonas putida+TX, Pseudomonas reactans+TX, Pseudomonas spp.+TX, Pseudomonas syringae +TX, Pseudomonas viridiflava +TX, Pseudomonas fluorescens +TX, Pseudozyma flocculosa strain PF-A22UL (Sporodex )+TX、Puccinia canaliculata+TX、Pucciniathlaspeos(Wood )+TX, Pythium paroecandrum+TX, Pythium oligandrum +TX, Pythium periplocum +TX, Rhanella aquatilis +TX, Rhanella spp. +TX, Rhizobia +TX, Rhizoctonia +TX, Rhodococcus globerulus strain AQ719 +TX, Rhodosporidium diobovatum +TX, Rhodosporidium toruloides +TX, Rhodotorula spp. +TX, Rhodotorula glutinis +TX, Rhodotorula graminis +TX, Rhodotorula mucilagnosa +TX, Rhodotorula rubra +TX, Saccharomyces cerevisiae +TX, Salinococcus roseus +TX, Sclerotinia minor +TX, Sclerotinia minor +TX, Scytalidium spp.+TX, Scytalidium uredinicola+TX, Spodoptera exigua nuclear polyhedrosis virus +TX, Serratia marcescens +TX, Serratia plymuthica +TX, Serratia spp. +TX, Sordaria fimicola +TX, Spodopteralittoralis nucleopolyhedrovirus +TX, Sporobolomyces roseus +TX, Stenotrophomonas maltophilia +TX, Streptomyces ahygroscopicus +TX, Streptomyces albaduncus +TX, Streptomyces exfoliates +TX, Streptomyces galbus +TX, Streptomyces griseoplanus +TX, Streptomyces griseoviridis +TX, Streptomyces lydicus +TX, Streptomyces lydicus WYEC-108 +TX, Streptomyces violaceus +TX, Tilletiopsis minor +TX, Tilletiopsis spp. +TX, Trichoderma asperellum (T34 )+TX, Trichoderma gamsii +TX, Trichoderma atroviride +TX, Trichoderma hamatum TH 382+TX, Trichoderma harzianum rifai +TX, Trichoderma harzianum T-22 ( PlantShield )+TX, Trichoderma harzianum T-39 +TX, Trichoderma inhamatum +TX, Trichoderma koningii +TX, Trichoderma spp. LC 52 +TX, Trichodermalignorum +TX, Trichoderma longibrachiatum +TX, Trichoderma polysporum (Binab )+TX, Trichoderma taxi+TX, Trichoderma virens+TX, Trichoderma virens (formerly known as Gliocladium virens GL-21) +TX, Trichoderma viride +TX, Trichoderma viride strain ICC 080 +TX, Trichosporon pullulans +TX, Trichosporon spp. +TX, Trichothecium spp. +TX, Trichothecium roseum +TX, Typhula phacorrhiza strain 94670 +TX, Typhula phacorrhiza strain 94671 +TX, Ulocladium atrum +TX, Ulocladium oudemansii +TX, Ustilago maydis +TX, various bacteria and supplementary nutrients (Natural )+TX, various fungi (Millennium )+TX, Verticillium chlamydosporium+TX, Verticillium lecanii +TX、Vip3Aa20 +TX, Virgibaclillus marismortui +TX, Xanthomonas campestris pv., Poae +TX, Xenorhabdus burnetii +TX, and Xenorhabdus nematophila +TX;

[0628] Plant extracts, including pine oil +TX, Azadirachtin (Plasma Neem )+TX, plant IGR +TX, canola oil (Lilly Miller )+TX, Chenopodium ambrosioides near ambrosioides +TX, chrysanthemum extract +TX, neem oil extract ( +TX, Labiatae essential oil +TX, clove-rosemary-peppermint and thyme oil extracts (Garden insect )+TX, betaine +TX, garlic +TX, lemongrass oil +TX, neem oil +TX, catnip (Nepeta cataria) (catnip oil) +TX, Nepeta catarina +TX, nicotine +TX, oregano oil +TX, Pedaliaceae oil +TX, Pyrethrum+TX, Soapbark Tree (Quillaja saponaria) +TX, +TX, rotenone (Eco )+TX, Rutaceae plant extract +TX, soybean oil (Ortho )+TX, Melaleuca alternifolia extract (also known as tea tree oil) (Timorex )+TX, thyme oil+TX, MMF+TX, +TX, Rosemary-Sesame-Peppermint-Thyme and Cinnamon Extract Blend (EF )+TX, clove-rosemary and peppermint extract mixture (EF )+TX, Clove-Peppermint-Garlic Oil and Mint Blend (Soil )+TX, kaolin +TX, storage glucan of brown algae +TX;

[0629] Pheromones, including: 3M Sprayable Blackheaded Fireworm )+TX, codling moth pheromone (Paramount dispenser-(CM) / Isomate )+TX, Grape Leaf Roller Pheromone (3MMEC-GBM Sprayable )+TX, leaf roller pheromone (3MMEC-LR Sprayable )+TX, housefly pheromone (Muscamone)(Snip7Fly Starbar Premium Fly )+TX, Pear fruit moth pheromone (3Moriental fruit moth sprayable )+TX, Peachtree Borer pheromone +TX, Tomato Pinworm Pheromone (3M Sprayable )+TX, Entostat powder (from palm tree extract) (Exosex )+TX、(3E,8Z,11Z)-3,8,11-tetradecatriene acetate+TX、(7Z,11Z,13E)-7,11,13-hexadecatrienal+TX、(E,Z)-7,9-dodecadien-1-yl acetate+TX、2-methyl-1-butanol+TX、calcium acetate+TX、 +TX, +TX, +TX, Lavandulyl senecioate+TX;

[0630] Macrobial agents, including: Aphidius ervi + TX, Aphidius ervi +TX, Acerophagus papaya+TX, Coccinella bispot +TX, Coccinella bispotata +TX, Coccinella bispotata +TX, Ageniaspis citricola +TX, Polyembryonic wasp +TX, Amblyseius andersoni +TX, Amblyseius californicus +TX, Amblyseius cucumber mite (

[0631] Bugline )+TX, Pseudo-Amblyseius +TX, Bugline )+TX, Amblyseius osbornei +TX, Amitus hesperidum +TX, Anagrus atomus +TX, Anagyrus fusciventris +TX, Anagyrus kamali +TX, Anagyrus loecki +TX, Anagyrus pseudococci +TX, Red wax scale flat-horned jumping wasp (Anicetus benefices) +TX, Golden wasp (Anisopteromalus calandrae) +TX, Woodland flower stink bug (Anthocoris nemoralis) +TX, short-spurred aphid wasp +TX, Aphelinus asychis +TX, Aphidius colemani +TX, Alphididae +TX, tobacco aphid wasp+TX, peach red aphid wasp +TX, aphid-eating gall midge +TX, aphid-eating gall midge +TX, Lingnan yellow aphid wasp +TX, Indian yellow aphid wasp +TX, Aprostocetus hagenowii +TX, Atheta coriaria +TX, Bombus species +TX, European bumblebee (Natupol )+TX, European bumblebee +TX, Cephalonomiastephanoderis+TX, Black-backed Ladybird (Chilocorus nigritus)+TX, Common Lacewing (Chrysoperlacarnea) +TX, Common Lacewing +TX, Chrysoperlarufilabris+TX, Cirrospilus ingenuus+TX, Cirrospilusquadristriatus+TX, Citrostichus phyllocnistoides+TX, Closterocerus chamaeleon+TX, Closterocerus species+TX, Coccidoxenoides perminutus +TX, Coccophagus cowperi+TX, Coccophagus lycimnia+TX, Cottontail wasp (Coccophagus lycimnia)+TX, Cottontail wasp (Coccophagus lutescens)+TX, Cottontail wasp (Coccophagus leucopsis)+TX, +TX, Japanese square-headed beetle+TX, Siberian gnathostome +TX, Siberian gnathostome +TX, Pea leafminer +TX, small black ladybug (Delphastus catalinae) +TX, Delphastus pusillus+TX, Diachasmimorpha krausii+TX, Diaparsis jucunda+TX, Diaphorencyrtus aligarhensis+TX, Diaphorencyrtus aligarhensis+TX, Diaphorencyrtus spp.+TX, Diaphorencyrtus spp. +TX, Siberian Braconidia +TX, Encarsia species+TX, Encarsia longita +TX, Encarsia spp. )+TX, Eretmocerus eremicus +TX, Encarsia guadeloupae +TX, Encarsia haitiensis +TX, Slender hoverfly +TX, Eretmoceris siphonini+TX, Eretmocerus californicus+TX, Eretmocerus eremicus Eretline )+TX, Eretmocerus eremicus +TX, Heinrichthys hymenoptera+TX, Monterey's hymenoptera Eretline )+TX, Eretmocerus siphonini+TX, Four-spotted Ladybird (Exochomus quadripustulatus)+TX, Feltiella acarisuga +TX, Acarina +TX, Alishan fly miner +TX, Fopius ceratitivorus +TX, Wirless )+TX, thrips slender waist +TX, Galendromus occidentalis +TX, Goniozus legneri +TX, Echinops serratus +TX, Harmonia axyridis +TX, Heterorhabditis species (Lawn )+TX, Heterorhabditis elegans (NemaShield )+TX, Heterorhabditis megidis (Nemasys BioNem Exhibitline )+TX, Hippodamiaconvergens+TX, Hypoaspis aculeifer +TX, Hypoaspis miles

[0632] (Hypoline )+TX, Black Branch Gall Wasp (Lbalialeucospoides)+TX, Lecanoideus floccissimus+TX, Lemophagus errabundus+TX, Three-Colored Beautiful Jumping Wasp (Leptomastidea abnormis)+TX, Leptomastix dactylopii +TX, Leptomastix epona+TX, Lindorus lophanthae+TX, Lipolexis oregmae+TX, Lucilia caesar +TX, Lysiphlebus testaceipes +TX, Macrolophus caliginosus ( Macroline )+TX, Mesoseiulus longipes+TX, Metaphycus flavus+TX, Metaphycus lounsburyi+TX, Micromus angulatus +TX, Microterys flavus +TX, Muscidifurax raptorellus and Spalangiacameroni +TX, Neodryinus typhlocybae+TX, Neoseiulus californicus+TX, Neoseiulus cucumeris +TX, Neoseiulus fallacis +TX, Nesideocoris tenuis +TX, Bronze Blackfly (Ophyra aenescens) +TX, Orius insidiosus( Oriline )+TX, Orius laevigatus ( Oriline )+TX、Orius majusculus(Oriline )+TX, small black stink bug (Orius strigicollis) +TX, Pauesiajuniperorum+TX, Pediobius foveolatus+TX, Phasmarhabditishermaphrodita +TX, Phymastichus coffea+TX, Phytoseiulusmacropilus+TX, Phytoseiulus persimilis ( Phytoline )+TX, Podisus maculiventris +TX, Pseudacteon curvatus+TX, Pseudacteon obtusus+TX, Pseudacteon tricuspis+TX, Pseudaphycus maculipennis+TX, Pseudleptomastix mexicana+TX, Psyllaephagus pilosus+TX, Psyttalia concolor (complex)+TX, Quadrastichus spp.+TX, Rhyzobius lophanthae+TX, Rodolia cardinalis+TX, Rumina decollate+TX, Semielacher petiolatus+TX, Sitobion avenae +TX, Steinernema carpocapsae (Nematac BioNem )+TX, Steinernema carinata ( Nemasys BioNem Exhibitline )+TX, Steinernema kraussei (Nemasys BioNem Exhibitline )+TX, Steinernema riobrave +TX, Steinernema scapterisci (Nematac )+TX、Steinernema spp.+TX、Steinernematid spp. )+TX, Stethorus punctillum +TX, Tamarixia radiate +TX, Tetrastichus setifer +TX, Thropobius semiluteus +TX, Torymus sinensis +TX, Tricholine )+TX, Trichogramma brassicae +TX, Trichogramma evanescens+TX, Trichogramma minutum+TX, Trichogramma ostriniae+TX, Trichogramma platneri+TX, Trichogramma pretiosum+TX, Xanthopimpla stemmator+TX;

[0633] Other biological agents, including: abscisic acid + TX, +TX, Chondrostereum purpureum (Chontrol )+TX, Colletotrichum spondyloticum +TX, copper octanoate +TX, Delta trap (Trapline )+TX, Erwinia amylovora (Harpin) ( Ni-HIBIT Gold )+TX, fatty acids derived from natural by-products of extra virgin olive oil , ferric phosphate +TX, Funneltrap (Trapline )+TX、 +TX, Grower's +TX, Homo-brassonolide +TX, Ferric Phosphate (Lilly Miller Worry Free Ferramol Slug & Snail )+TX、MCP hail trap (Trapline )+TX, parasitic insect Microctonus hyperodae+TX, Mycoleptodiscus terrestris +TX, +TX, +TX, +TX, Pheromone Net (Thripline )+TX, potassium bicarbonate +TX, potassium salt of fatty acids +TX, potassium silicate solution +TX, potassium iodide + potassium thiocyanate +TX, +TX, spider venom +TX, locust microsporidia (Semaspore Organic Grasshopper )+TX, Trapline Rebell )+TX and captured y+ )+TX;

[0634] (1) An antibacterial agent selected from the group consisting of:

[0635] (1.1) Bacteria, examples of which are Bacillus mojavensis strain R3B (accession number NCAIM (P) B001389) (WO 2013 / 034938), from Certis USA LLC +TX; Bacillus pumilus, in particular strain BU F-33, with NRRL accession number 50185 (from BASF); EPA registration number 71840-19) + TX; Bacillus subtilis, in particular strain QST713 / AQ713 (SERENADE OPTI or SERENADE ASO from Bayer CropScience LP, USA, with NRRL registration number B21661, U.S. Patent No. 6,060,051) + TX; Bacillus subtilis strain BU1814, (from BASF SE PLUS, FLEX and EXTRA) + TX; Bacillus subtilis variant amyloliquefaciens strain FZB24, with registration number DSM 10271 (available as or ECO (EPA registration number 70127-5) obtained from Novozymes) + TX; Bacillus subtilis CX-9060 + TX from Certis USA LLC; Bacillus species, specifically strain D747 (available as DOUBLE obtained from Kumiai Chemical Industry Co., Ltd.) with accession number FERM BP-8234, U.S. Patent No. 7,094,592+TX; Paenibacillus sp. strains with accession number NRRL B-50972 or accession number NRRL B-67129, WO 2016 / 154297+TX; Paenibacillus polymyxa, particularly strain AC-1 (e.g., from Green Biotech Company Ltd.) ) + TX; Pantoea agglomerans, in particular strain E325 (accession number NRRL B-21856) (available as BLOOMTIME BIOLOGICAL TM FD BIOPESTICIDE (from Northwest Agri Products) + TX; Pseudomonas proradix (e.g., from Sourcon Padena) )+TX; and

[0636] (1.2) Fungi, examples of which are Aureobasidium pullulans, in particular blastospores of strain DSM 14940, blastospores of strain DSM 14941 or a mixture of blastospores of strains DSM 14940 and DSM 14941 (e.g., blastospores from bio-ferm, Switzerland). and BLOSSOM )+TX; Pseudozyma aphidis (as disclosed in WO 2011 / 151819 by Yissum Research Development Company of the Hebrew University of Jerusalem)+TX; Saccharomyces cerevisiae, in particular strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938 or CNCM No. 1-3939 (as disclosed in WO 2010 / 086790, from Lesaffre et Compagnie, France)+TX;

[0637] (2) Biofungicides selected from the group consisting of:

[0638] (2.1) Bacteria, an example of which is Agrobacterium radiobacterium strain K84 (e.g., from AgBioChem, California) )+TX; radiobacterium strain K1026 (e.g. NOGALL from BASF TM )+TX; Bacillus subtilis variant amyloliquefaciens strain FZB24, with registration number DSM 10271 (available as or ECO (EPA registration number 70127-5) obtained from Novozymes) + TX; Bacillus amyloliquefaciens, specifically strain D747 (available as Double Nickel TM obtained from Kumihiko Chemical Industries, Ltd., with accession number FERM BP-8234, U.S. Patent No. 7,094,592) + TX; Bacillus amyloliquefaciens strain F727 (also known as strain MBI110) (NRRL accession number B-50768, WO 2014 / 028521) (from Marrone BioInnovations )+TX; Bacillus amyloliquefaciens strain FZB42, registration number DSM 23117, (can be used as from ABiTEP, Germany) + TX; Bacillus amyloliquefaciens isolate B246 (e.g., AVOGREEN from the University of Pretoria); TM)+TX; Bacillus licheniformis, in particular strain SB3086, having accession number ATCC 55406, WO 2003 / 000051 (available as Biofungicides and Green Release TM Bacillus licheniformis FMCH001 and Bacillus subtilis FMCH002 (from FMC Corporation) (WG) and (WP)) + TX; Bacillus methylotrophicus strain BAC-9912 (from the Institute of Applied Ecology, Chinese Academy of Sciences) + TX; Bacillus mojavensis strain R3B (accession number NCAIM(P)B001389) (WO 2013 / 034938), from Certis USA, Inc. + TX; Bacillus mycoides isolate with accession number B-30890 (available as BMJ or WG and LifeGard TM obtained from Surtice USA) + TX; Bacillus pumilus, specifically strain QST2808 (available as obtained from Bayer CropScience, USA, with registration number NRRL B-30087 and described in US Pat. No. 6,245,551) + TX; Bacillus pumilus, in particular strain GB34 (available as Yield pumilus, in particular strain BU F-33, having NRRL accession number 50185 (available as part of the CARTISSA product from BASF, EPA accession number 71840-19) + TX; Bacillus subtilis, in particular strain QST713 / AQ713 (available as SERENADE OPTI or SERENADE ASO from Bayer CropScience LP in the United States, having NRRL accession number B21661, and described in U.S. Patent No. 6,060,051) + TX; Bacillus subtilis Y1336 (available as WP was obtained from Bion-Tech, Taiwan, China, and registered as a biofungicide in Taiwan under registration numbers 4764, 5454, 5096, and 5277) + TX; Bacillus subtilis strain MBI 600 (available as SUBTILEX from BASF, with registration number NRRL B-50595, U.S. Patent No. 5,061,495) + TX; Bacillus subtilis strain GB03 (available as obtained from Bayer AG, Germany) + TX; Bacillus subtilis strain BU1814, (available as PLUS, FLEX and EXTRA obtained from BASF) + TX; Bacillus subtilis CX-9060 + TX from Certis USA LLC; Bacillus subtilis KTSB strain (from Donaghys )+TX; Bacillus subtilis IAB / BS03 (AVIV from STK Bio-Ag Technologies) TM , from Idai Nature )+TX; Bacillus subtilis strain Y1336 (can be used as WP was obtained from Biotech, Taiwan, China, and registered as a biofungicide in Taiwan under registration numbers 4764, 5454, 5096, and 5277) + TX; Paenibacillus epiphyticus (WO 2016 / 020371) from BASF + TX; Paenibacillus polymyxa plantarum species (WO 2016 / 020371) from BASF + TX; Paenibacillus species strains with registration number NRRL B-50972 or registration number NRRL B-67129, WO 2016 / 154297 + TX; Pseudomonas chlororaphis strain AFS009 with registration number NRRL B-50897, WO 2017 / 019448 (e.g., HOWLER from AgBiome Innovations, USA) TM and ) + TX; Pseudomonas chlororaphis strains, in particular strain MA342 (e.g., from Bioagri and Koppert); and )+TX; Pseudomonas fluorescens strain A506 (e.g., from NuFarm A506) + TX; Pseudomonas proradix (e.g., from Soconpadna) ) + TX; Streptomyces griseoviridis strain K61 (also known as Streptomyces luteus strain K61) (accession number DSM 7206) (from Verdera BioWorks See Crop Protection 2006, 25, 468-475) + TX; Streptomyces lydicus strain WYEC108 (also known as Streptomyces lydicus strain WYCD108US) (from Novozymes and )+TX; and

[0639] (2.2) Fungi, an example of which is Pseudomonas aeruginosa, in particular strain AQ 10 (e.g. AQ from IntrachemBio Italia) )+TX; Pseudomonas graminearum strain AQ10, with accession number CNCM 1-807 (e.g., AQ from Intrachem Biologia Italia S.A. )+TX; Aspergillus flavus strain NRRL21882 (as a and known products) + TX; budding mold, especially the spores of strain DSM14940 + TX; budding mold, especially the spores of strain DSM 14941 + TX; budding mold, especially the mixture of spores of strains DSM14940 and DSM 14941 (for example, from Bio-Philippe Co., Ltd., Switzerland )+TX; Chaetomium cupreum (accession number CABI 353812) (e.g., BIOKUPRUM from AgriLife TM )+TX; Chaetomium globosum (can be used as from Rivale) + TX; Cladosporium cladosporioides, strain H39, with accession number CBS122244, US2010 / 0291039 (from Wageningen Research Foundation (Stichting Dienst Landbouwkundig Onderzoek)) + TX; Coniothyrium minitans, in particular strain CON / M / 91-8 (accession number DSM9660, e.g., from Bayer CropScience Biologics GmbH) + TX; )+TX; Cryptococcus flavescens, strain 3C (NRRL Y-50378), (B2.2.99)+TX; Dactylaria candida+TX; Dilophosphora alopecuri (can be used as TWIST Obtain) + TX; Fusarium oxysporum, strain Fo47 (can be used as obtained from Natural Plant Protection) + TX; Gliocladium catenulatum (synonym: Clonostachys rosea f. catenulate) strain J1446 (e.g., from Lallemand) )+TX; Gliocladium roseum (also known as Clonostachys rosea), in particular strain 321U from Adjuvants Plus, strain ACM941 as disclosed in Xue AG (Efficacy of Clonostachys rosea strain ACM941 and fungicide seed treatments for controlling the root tot complex of field pea, Can J. Plant Sci., 2003, 83(3):519-524), or strain IK726 (Jensen DF et al. Development of a biocontrol agent for plant disease control with special emphasis on the near commercial fungal agonist Clonostachys rosea strain 'IK726' [with particular emphasis on the development of a biocontrol agent for plant disease control using the near-commercial fungal antagonist Gliocladium roseum strain 'IK726'], Australasian Plant Pathol. 2007, 36(2):95-101) + TX; conidia of Lecanicillium lecanii (formerly Verticillium lecanii) strain KV01 (e.g., from Corbett / Arysta )+TX; Metschnikowia fructicola, in particular strain NRRL Y-30752, (B2.2.3)+TX; Microsphaeropsis ochracea+TX; Muscodor roseus, in particular strain A3-5 (accession number NRRL 30548)+TX; Penicillium steckii (DSM 27859, WO 2015 / 067800) from BASF+TX; Penicillium vermiculatum+TX; Phlebiopsis gigantean strain VRA 1992 (from Danstar Ferment) C) + TX; Pichia anomala, strain WRL-076 (NRRL Y-30842), U.S. Patent No. 7,579,183 + TX; Pseudozyma flocculosa, strain PF-A22 UL (can be used as L obtained from Plant Products Co., California) + TX; Saccharomyces cerevisiae, specifically strain LASO2 (from Agro-Levures et Dérivés), strain LAS117 cell wall (from Lesaffre From BASF ), strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938, CNCM No. 1-3939 (WO 2010 / 086790) + TX from Lesaffre, France; Simplicillium lanosoniveum + TX; Talaromyces flavus, strain V117b + TX; Trichoderma asperelloides JM41R (registration number NRRL B-50759) (from TRICHO )+TX; Trichoderma asperellum, in particular strain kd (e.g., T-Gro from Andermatt Biocontrol)+TX; Trichoderma asperellum, in particular strain SKT-1, having accession number FERM P-16510 (e.g., ), strain T34 (e.g., T34 from Biocontrol Technologies SL, Spain) or strain ICC012+TX from Isagro; Trichoderma atroviride, in particular strain SC1 (accession number CBS 122089, WO 2009 / 116106 and U.S. Pat. No. 8,431,120 (from Bi-PA), strain 77B (T77 from Andermat Biocontrol) or strain LU132 (e.g., Sentinel from Agrimm Technologies Limited)+TX; Trichoderma atroviride, strain CNCM1-1237 (e.g., strain Agrauxine from France) WP)+TX; Trichoderma atroviride, strain number V08 / 002387+TX; Trichoderma atroviride, strain NMI number V08 / 002388+TX; Trichoderma atroviride, strain NMI number V08 / 002389+TX; Trichoderma atroviride, strain NMI number V08 / 002390+TX; Trichoderma atroviride, strain LC52 (e.g., Tenet from Agri-Mount Technologies Ltd.)+TX; Trichoderma atroviride, strain ATCC 20476 (IMI 206040)+TX; Trichoderma atroviride atroviride), strain T11 (IMI352941 / CECT20498) + TX; Trichoderma atroviride, strain SKT-1 (FERM P-16510), Japanese Patent Publication (Kokai) 11-253151A + TX; Trichoderma atroviride, strain SKT-2 (FERM P-16511), Japanese Patent Publication (Kokai) 11-253151A + TX; Trichoderma atroviride, strain SKT-3 (FERM P-17021), Japanese Patent Publication (Kokai) 11-253151A+TX; Trichoderma fertile (e.g., TrichoPlus from BASF) + TX; Trichoderma germinata (Trichoderma germinata), strain ICC 080 (IMICC 392151CABI, e.g., BioDerma from AGROBIOSOL DE MEXICO, SADE CV) + TX; Trichoderma germinata (Trichoderma germinata), strain ICC 080 (IMICC 392151CABI) (can be used as obtained from Agribelso Mexico) + TX; Trichoderma harmatum + TX; Trichoderma harmatum, with accession number ATCC 28012 + TX; Trichoderma harzianum strain T-22 (e.g., Trianum-P from Andermatt Biocontrol or Kobert) or strain Cepa Simb T5 (from Simbiose Agro) + TX; Trichoderma harzianum + TX; Trichoderma harzianum slant (rifai) T39 (e.g., from Makhteshim, USA) )+TX; Trichoderma harzianum, strain ITEM 908 (e.g., Trianum-P from Kobert)+TX; Trichoderma harzianum, strain TH35 (e.g., Root-Pro from Mycontrol)+TX; Trichoderma harzianum, strain DB 103 (available as 7456 from Dagutat Biolab) + TX; Trichoderma polysporum, strain IMI206039 (e.g., Binab TFWP from BINAB Bio-Innovation AB, Sweden) + TX; Trichoderma stromaticum, with accession number Ts3550 (e.g., Tricovab from CEPLAC, Brazil) + TX; Trichoderma virens (also known as Gliocladium virens), in particular strain GL-21 (e.g., SoilGard from Certis, USA) + TX; Trichoderma virens strain G-41, formerly known as Gliocladium virens (accession number ATCC 20906) (e.g., from Biovox, USA) + TX; PLUS WP and PLUS WP) + TX; Trichoderma viride, strain TV1 (e.g., Trianum-P from Kobert) + TX; Trichoderma viride, in particular strain B35 (Pietr et al., 1993, Zesz. Nauk. AR w Szczecinie [Science of the Agricultural University of Szczecin] 161: 125-137) + TX; a mixture of Trichoderma asperellum strain ICC 012 (also known as Trichoderma harzianum ICC 012) (with the accession number CABI CC IMI 392716) and Trichoderma gamsii (formerly Trichoderma viride) strain ICC 080 (with the accession number IMI 392151) (e.g., BIO-TAM® from Esig USA, Inc. TM and from Agriberso Mexico )+TX; Ulocladium oudemansii strain U3, having accession number NM 99 / 06216 (e.g., from Botry-Zen Ltd, New Zealand) and from Byworth )+TX; Verticillium albo-atrum (formerly V. dahliae), strain WCS850, having accession number WCS850, deposited with the Central Bureau for Fungi Cultures (e.g., by Tree Care Innovations, DUTCH )+TX; Verticillium chlamydosporium+TX;

[0640] (3) Biological control agents having the effect of improving plant growth and / or plant health selected from the following group:

[0641] (3.1) Bacteria, an example of which is Azospirillum brasilense (e.g., from KALO, Inc.) )+TX; Azospirillum lipoferum (e.g., VERTEX-IF from TerraMax, Inc.) TM)+TX; Azorhizobium caulinodans, in particular strain ZB-SK-5+TX; Azotobacter chroococcum, in particular strain H23+TX; Azotobacter vinelandii, in particular strain ATCC 12837+TX; a mixture of Azotobacter vinelandii and Clostridium pasteurianum (which can be used as from Agrinos) + TX; Bacillus amyloliquefaciens pm414 (from Biofilm Crop Protection) )+TX; Bacillus amyloliquefaciens SB3281 (ATCC#PTA-7542, WO 2017 / 205258)+TX; Bacillus amyloliquefaciens TJ1000 (can be used as Bacillus amyloliquefaciens, in particular strain IN937a+TX; Bacillus amyloliquefaciens, in particular strain FZB42 (e.g., from Abbott, Germany). ) + TX; Bacillus amyloliquefaciens BS27 (accession number NRRL B-5015) + TX; EE128 (NRRL No. B-50917) + TX; EE349 (NRRL No. B-50928) + TX; Bacillus cereus, in particular strain BP01 (ATCC 55675, for example, from Arysta Lifescience, USA ) + TX; Bacillus firmus, in particular strain CNMC 1-1582 (e.g., from BASF )+TX; Bacillus mycoides BT155 (NRRL No. B-50921)+TX; Bacillus mycoides EE118 (NRRL No. B-50918)+TX; Bacillus mycoides EE141 (NRRL No. B-50916)+TX; Bacillus mycoides BT46-3 (NRRL No. B-50922)+TX; Bacillus pumilus, in particular strain QST2808 (accession number NRRL No. B-30087)+TX; Bacillus pumilus, in particular strain GB34 (e.g., YIELD® from Bayer CropScience, Germany) )+TX; Bacillus siamensis, particularly strain KCTC 13613T+TX; Bacillus subtilis, particularly strain QST713 / AQ713 (having NRRL accession number B-21661 and described in U.S. Patent No. 6,060,051, can be used as OPTI or ASO was obtained from Bayer CropScience, Inc., USA) + TX; Bacillus subtilis, in particular strain AQ30002 (accession number NRRL No. B-50421 and described in U.S. patent application No. 13 / 330,576) + TX; Bacillus subtilis, in particular strain AQ30004 (and NRRL No. B-50455 and described in U.S. patent application No. 13 / 330,576) + TX; Bacillus subtilis strain BU1814 (available as from BASF), Bacillus subtilis rm303 (from Biofilm Crop Protection ) + TX; Bacillus thuringiensis BT013A (NRRL No. B-50924), also known as Bacillus thuringiensis 4Q7 + TX; a mixture of Bacillus licheniformis FMCH001 and Bacillus subtilis FMCH002 (can be used as (WG), (WP) obtained from FMC Corporation) + TX; Bacillus subtilis, in particular strain MBI 600 (e.g., from BASF )+TX; Bacillus equilensis, especially strain NII-0943+TX; Bradyrhizobium sojae zo bium japonicum) (e.g., from Novozymes )+TX; Delftia acidovorans, in particular strain RAY209 (e.g., from Brett Young Seeds )+TX; Mesorhizobium chinense zo biumcicer) (e.g., NODULATOR from BASF) + TX; Lactobacillus species (e.g., Lactobacillus from LactoPAFI) )+TX; Rhizobium leguminosae (Rhi zobium leguminosarium biovar viciae) (e.g. NODULATOR from BASF) + TX; Pseudomonas proradix (e.g. ) + TX; Pseudomonas aeruginosa, in particular strain PN1 + TX; Rhizobium leguminosarum, in particular Rhizobium vitis vinifera (bv. viceae) strain Z25 (accession number CECT 4585) + TX; Bacillus polymyxa, in particular strain AC-1 (e.g., from Green Biotechnology Co., Ltd. ) + TX; Serratia marcescens, in particular strain SRM (accession number MTCC8708) + TX; Sinorhizobium meliloti strain NRG-185-1 (from Bayer CropScience GOLD) + TX; Thiobacillus sp. (e.g., from Cropaid Ltd, UK) )+TX; and

[0642] (3.2) Fungi, examples of which are Purpureocillium lilacinum (formerly Paecilomyces lilacinus) strain 251 (AGAL 89 / 030550, e.g., BioAct from Bayer CropScience Bio) +TX; Penicillium bilaii, strain ATCC 22348 (e.g., from Acceleron BioAg); ), Talaromyces flavus, strain V117b+TX; Trichoderma atroviride strain CNCM 1-1237 (e.g., from Aglaocosin, France); WP), Trichoderma viride, for example, strain B35 (Pietr et al., 1993, Zesz. Nauk. AR w Szczecinie [Science of the Agricultural University of Szczecin] 161: 125-137) + TX; Trichoderma atroviride strain LC52 (also known as Trichoderma atroviride strain LU132, for example, from Agri-Mountain Technology Ltd. )+TX; Trichoderma atroviride strain SC1 (described in WO2009 / 116106)+TX; Trichoderma asperellum strain kd (e.g., T-Gro from Andermatt Biocontrol)+TX; Trichoderma asperellum strain (Eco-T from Plant Health Products of New Zealand)+TX, Trichoderma harzianum strain T-22 (e.g., Trianum-P from Andermatt Biocontrol or Cobert)+TX; Myrotheca verrucosa strain AARC-0255 (e.g., DiTera from Valent Biosciences) TM )+TX; Penicillium bilaii strain ATCC ATCC20851+TX; Pythium oligandrum strain M1 (ATCC 38472, for example, Polyversum from Bioprepraty, Czech Republic)+TX; Trichoderma virens strain GL-21 (for example, from Sertis, USA) )+TX; Verticillium albo-atrum (formerly V. dahliae) strain WCS850 (CBS276.92, for example, DutchTrig from Tree Care Innovations)+TX; Trichoderma atroviride, in particular strain No. V08 / 002387, strain No. NMI No. V08 / 002388, strain No. NMI No. V08 / 002389, strain No. NMI No. V08 / 002390+TX; Trichoderma harzianum strain ITEM 908, Trichoderma harzianum strain TSTh20+TX; Trichoderma harzianum harzianum) strain 1295-22 + TX; Pythium oligandrum strain DV74 + TX; Rhizopogon amylopogon (e.g., Myco-Sol from Agri-Enterprise, LLC, formerly Helena Chemical Company) + TX; Rhizopogon fulvigleba (e.g., Myco-Sol from Agri-Enterprise, LLC, formerly Helena Chemical Company) + TX; Trichoderma virens strain GI-3 + TX;

[0643] (4) Insecticidal biological control agents selected from the following

[0644] (4.1) Bacteria, examples of which are Agrobacterium radiobacterium strain K84 (Galltrol from Egger Biochemicals) + TX; Bacillus amyloliquefaciens, in particular strain PTS-4838 (e.g., AVEO from Hualun Biosciences, USA) + TX; Bacillus firmus, in particular strain CNMC 1-1582 (e.g., from BASF ) + TX; Bacillus mycoides, isolate J. (e.g., BmJ from Certis USA LLC) + TX; Bacillus sphaericus, particularly serotype H5a5b strain 2362 (strain ABTS-1743) (e.g., from Hualun Biosciences, Inc., USA ) + TX; Bacillus thuringiensis subsp. aizawai, in particular strain ABTS-1857 (SD-1372, e.g., from Hualun Biosciences ) + TX; Bacillus thuringiensis subsp. aizawai, particularly serotype H-7 (e.g., from Hualun Biosciences, USA WG) + TX; Bacillus thuringiensis israelensis strain BMP 144 (e.g., from Becker Microbial Products, Inc., Illinois); ) + TX; Bacillus thuringiensis subsp. israelensis (serotype H-14) strain AM65-52 (accession number ATCC 1276) (e.g., from Hualun Biosciences, USA )+TX; Bacillus thuringiensis subsp.ai zawa i) strain GC-91+TX; Bacillus thuringiensis var. Colmeri (e.g., TIANBAOBTC from Changzhou Jianghai Chemical Factory)+TX; Bacillus thuringiensis Japonica strain Buibui+TX; Bacillus thuringiensis subsp. kurstaki strain BMP 123 (from Becker Microbial Products, Inc., Illinois, BARITONE from Bayer CropScience)+TX; Bacillus thuringiensis subsp. kurstaki strain HD-1 (e.g., from Hualun Biosciences, Inc., USA) ES) + TX; Bacillus thuringiensis var. kurstak strain EVB-113-19 (e.g., from AEF Global )+TX; Bacillus thuringiensis subsp. Kurstaki strain ABTS 351+TX; Bacillus thuringiensis subsp. Kurstaki strain PB 54+TX; Bacillus thuringiensis subsp. Kurstaki strain SA 11, (JAVELIN from Sertis, USA)+TX; Bacillus thuringiensis subsp. Kurstaki strain SA 12 (THURICIDE from Sertis, USA)+TX; Bacillus thuringiensis subsp. Kurstaki strain EG 2348 (from Sertis, USA) )+TX; Bacillus thuringiensis subsp. Kurstaki strain EG 7841 (from Sertis, USA ) + TX; Bacillus thuringiensis subsp. tenebrionis strain NB 176 (SD-5428, e.g., BioFa, Germany) FC) + TX; Brevibacillus laterosporus (from Ecolibrium Biologicals) )+TX; Burkholderia spp., in particular Burkholderia rinojensis strain A396 (also known as Burkholderia strain MBI 305) (Accession No. NRRL B-50319); WO 2011 / 106491 and WO 2013 / 032693; for example, MBI206 TGAI and )+TX; Chromobacterium subtsugae, particularly strain PRAA4-1T (e.g., MBI-203; e.g., from Maroni Bioinnovations )+TX; Lecanicillium muscarium Ve6 (MYCOTAL from Kobert)+TX; Paenibacillus popilliae (formerly Bacillus popilliae)+TX; MILKY SPORE POWDER from St. Gabriel Laboratories TM or MILKYSPORE GRANULAR TM ) + TX; Pasteurella pseudoszavara strain Pn1 (CLARIVA from Syngenta / China National Chemical Corporation) + TX; Serratia entomophila (e.g., Wrightson Seeds) )+TX; Serratia marcescens, in particular strain SRM (accession number MTCC 8708)+TX; Trichoderma asperellum (TRICHODERMAX from Novozymes)+TX; Wolbachia pipientis ZAP strain (e.g., ZAP from MosquitoMate) )+TX; and

[0645] (4.2) Fungi, an example of which is Beauveria bassiana strain ATCC 74040 (e.g., from Intrachem Bio, Italy). ) + TX; Beauveria bassiana strain GHA (Accession No. ATCC 74250, e.g., from Laverlam International Corporation) ES and ) + TX; Beauveria bassiana strain ATP02 (accession number DSM 24665) + TX; Isaria fumosorosea (formerly known as Paecilomyces fumosoroseus) strain Apopka 97 (from SePRO )+TX; Metarhizium anisopliae 3213-1 (deposited under NRRL Accession No. 67074, disclosed in WO 2017 / 066094; Pioneer Hi-Bred International)+TX; Metarhizium robertsii z ium robertsii)15013-1 (deposited under NRRL accession number 67073) + TX; Metarhizium robertsii z ium robertsii) 23013-3 (deposited under NRRL accession number 67075) + TX; Paecilomyces lilacinus strain 251 (from Sertis, USA )+TX; Zoophtoraradicans+TX;

[0646] (5) A virus selected from the group consisting of: summer fruit tortrix granulovirus (GV) + TX; Cydia pomonella (codling moth) granulovirus (GV) + TX; Helicoverpa armigera (cotton bollworm) nuclear polyhedrosis virus (NPV) + TX; Spodoptera exigua (beet armyworm) mNPV + TX; Spodoptera frugiperda (fall armyworm) mNPV + TX; Spodoptera littoralis (African cotton moth) NPV + TX;

[0647] (6) Bacteria and fungi selected from the group consisting of Agrobacterium spp. + TX; Azorhizobium caulinodans + TX; Azospirillum spp. + TX; Azotobacter spp. + TX; Bradyrhizobium spp. + TX; Burkholderia spp., in particular Burkholderia cepacia (formerly known as Pseudomonas cepacia) + TX; Gigaspora spp. or Gigaspora monosporum + TX; Glomus spp. + TX; Laccaria spp. + TX; Lactobacillus buchneri + TX; Paraglomus spp. spp.) + TX; Pisolithus tinctorus + TX; Pseudomonas species + TX; Rhizobium species, especially Rhizobium trifolii + TX; Rhizopogon species + TX; Scleroderma species + TX; Suillus species + TX; Streptomyces species + TX;

[0648] (7) Plant extracts and products formed by microorganisms (including proteins and secondary metabolites) that can be used as biocontrol agents, selected from garlic (Allium sativum) (NEMGUARD from Eco-Spray; BRALIC from ADAMA) + TX; Armour-Zen + TX; Artemisia absinthium + TX; azadirachtin (e.g., AZATIN XL from Sertis, USA) + TX; Biokeeper WP + TX; extracts from the Brassicaceae family, in particular rapeseed meal or mustard meal + TX; Cassia nigricans + TX; Celastrus angulatus + TX; Chenopodium anthelminticum + TX; chitin + TX; Dryopteris filix-mas + TX; Equisetum arvense + TX; arvense)+TX; Fortune Aza+TX; Fungastop+TX; Quinoa saponin extract from quinoa seeds (such as HeadsUp plant Protectants from Canada) (quinoa saponins) + TX; naturally occurring Blad peptide extracted from lupin seeds (from Certis EU ) + TX; naturally occurring Blad polypeptide extracted from lupin seeds (from FMC )+TX; Pyrethrum / Pyrethrins+TX; Quassia amara+TX; Quercus+TX; Quillaja extract (QL AGRI 35 from BASF)+TX; Giant knotweed extract (from MarroneBio) MAXX)+TX; "Requiem TM"Insecticide" + TX; Rotenone + TX; Ryania / ryanodine + TX; Symphytum officinale + TX; Artemisia selengensis + TX; Thymol + TX; Thymol mixed with Geraniol (CEDROZ from Eden Research) + TX; Thymol mixed with Geraniol and Eugenol (CEDROZ from Eden Research) + TX; )+TX; Triact 70+TX; TriCon+TX; Tropaeulum majus+TX; Melaleuca alternifolia (TIMOREX GOLD from Stockton Company (STK))+TX; Urtica dioica+TX; Veratrin+TX; and Viscum album+TX; and

[0649] Safeners such as fenoxacorb+TX, cloquintocet-mexyl (including cloquintocet-mexyl)+TX, cyclopropylsulfonamide+TX, dichloropropane+TX, fenoxacorb (including fenoxac-ethyl)+TX, fenoxacorb+TX, fluazifop+TX, fenoxacorb+TX, isoxadiazole+TX, isoxadiazole (including isoxadiazole-ethyl)+TX, mefenpyr (including mefenpyr-diethyl)+TX, metcamifen+TX and fenoxacorb+TX.

[0650] In addition, the compositions of the present invention may also be administered with one or more inducers of systemic acquired resistance ("SAR" inducers). SAR inducers are known and described, for example, in U.S. Pat. No. 6,919,298 and include, for example, salicylates and the commercial SAR inducer acibenzolar-S-methyl.

[0651] The compounds of formula (I) defined in the present invention are usually used in the form of compositions and can be applied to crop areas or crops to be treated simultaneously or sequentially with other compounds. For example, these other compounds can be fertilizers or micronutrient donors or other formulations that affect plant growth. They can also be selective herbicides or non-selective herbicides, together with insecticides, fungicides, bactericides, nematicides, molluscicides or mixtures of several of these formulations, if desired together with other carriers, surfactants or adjuvants commonly used in the formulation field to promote application.

[0652] The compounds of formula (I) defined according to the invention can be used in the form of (fungicide) compositions for controlling or protecting against phytopathogenic microorganisms, these compositions comprising at least one compound of formula (I) as defined in any one of Examples 1 to 43 or at least one of the various compounds preferably defined above as active ingredient (in free form or in the form of agrochemically usable salts) and at least one of the above-mentioned adjuvants.

[0653] Therefore, the present invention provides a composition, preferably a fungicidal composition, comprising at least one compound of formula (I) as defined herein, an agriculturally acceptable carrier and optionally an adjuvant. An agriculturally acceptable carrier is, for example, a carrier suitable for agricultural use. Agricultural carriers are well known in the art. Preferably, in addition to comprising a compound of formula (I) as defined herein, the composition may comprise at least one or more pesticidal active compounds, such as additional fungicidal active ingredients.

[0654] Another aspect of the present invention relates to a method for controlling or preventing infestation of plants, for example useful plants (such as crop plants), their propagation materials (such as seeds), harvested crops (such as harvested food crops), or non-living materials by phytopathogenic microorganisms or spoilage microorganisms or organisms potentially harmful to humans (especially fungal organisms), which method comprises applying a compound of formula (I) as defined in the present invention or preferably various compounds as defined above as active ingredients to these plants, parts of these plants or their locus, their propagation materials, or any part of these non-living materials.

[0655] Control or prevention means the reduction of infestation by insects or phytopathogenic or spoilage microorganisms or organisms potentially harmful to humans, especially fungal organisms, to such a level that an improvement is demonstrated.

[0656] The preferred method of controlling or preventing crop plants from being infected by plant pathogenic microorganisms (especially fungal organisms) is leaf application, which includes applying a compound with formula (I) as defined by the present invention or an agrochemical composition containing at least one of the compound. Frequency of application and application ratio will depend on the risk of infection by corresponding pathogens or insects. However, the compound with formula (I) as defined by the present invention can also be applied to the soil (soil application) by root (systemic action) penetration of plants by soaking the site of plants with liquid formulations or by applying the compound in solid form, for example, in granular form to the soil. In rice crops, such granules can be applied to the paddy field of irrigation. The compound with formula (I) as defined by the present invention can also be applied to seeds (coating) by impregnating seeds or tubers with the liquid formulations of fungicides or dressing them with solid formulations.

[0657] Formulations (e.g. compositions containing a compound of formula (I) as defined herein and, if desired, solid or liquid adjuvants or monomers for encapsulating a compound of formula (I) as defined herein) can be prepared in a known manner, typically by intimately mixing and / or grinding the compound with extenders (e.g. solvents, solid carriers and optionally surface-active compounds (surfactants)).

[0658] The methods of applying these compositions, i.e., methods for controlling the above-mentioned types of pathogens, such as spraying, atomizing, dusting, brushing, coating, broadcasting or pouring - which are selected to be suitable for the intended purpose of the prevailing situation - and the use of these compositions for controlling the above-mentioned types of pathogens are other themes of the present invention. Typical concentration ratios are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm of active ingredient. The application rate per hectare is preferably 1 g to 2000 g of active ingredient per hectare, more preferably 10 to 1000 g / ha, most preferably 10 to 600 g / ha. When used as a seed soaking agent, a suitable dosage is from 10 mg to 1 g of active substance / kg seed.

[0659] When the combination according to the invention is used to treat seed, a ratio of 0.001 to 50 g of compound of formula (I) per kg of seed, preferably from 0.01 to 10 g / kg of seed, is generally sufficient.

[0660] Suitably, the composition according to the invention comprising a compound of formula (I) as defined herein is applied prophylactically (meaning before the disease develops) or therapeutically (meaning after the disease develops).

[0661] The composition of the present invention can be used in any conventional form, for example, in the form of a twin pack, a dry seed treatment powder (DS), a seed treatment emulsion (ES), a seed treatment flowable concentrate (FS), a seed treatment solution (LS), a seed treatment water-dispersible powder (WS), a seed treatment capsule suspension (CF), a seed treatment gel (GF), an emulsion concentrate (EC), a suspension concentrate (SC), a suspoemulsion (SE), a capsule suspension (CS), a water-dispersible granule (WG), an emulsifiable granule (EG), an oil-in-oil emulsion (EO), an oil-in-water emulsion (EW), a microemulsion (ME), an oil dispersion (OD), an oil suspension concentrate (OF), an oil-soluble liquid (OL), a soluble concentrate (SL), an ultra-low volume suspension concentrate (SU), an ultra-low volume liquid (UL), a concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP) or any technically feasible formulation in combination with agriculturally acceptable adjuvants.

[0662] Such compositions can be produced in a conventional manner, for example by mixing the active ingredient with appropriate formulation inerts (diluents, solvents, fillers and optionally other formulation ingredients such as surfactants, biocides, antifreeze agents, adhesives, thickeners and compounds providing auxiliary effects). Conventional sustained-release formulations intended for long-term efficacy can also be used. In particular, formulations to be applied in the form of a spray (such as water-dispersible concentrates (e.g., EC, SC, DC, OD, SE, EW, EO, etc.), wettable powders and granules) can contain surfactants (such as wetting agents and dispe...

Claims

1. A compound having formula (I) wherein Ring W is a 5-8 membered carbocyclic ring, a 5-8 membered heterocyclic ring, a 6-12 membered aromatic ring or a 5-11 membered heteroaromatic ring, wherein each of the 5-8 membered carbocyclic ring, the 5-8 membered heterocyclic ring, the 6-12 membered aromatic ring or the 5-11 membered heteroaromatic ring is optionally replaced by one to four independently selected R 1 Substituents substituted; A is CH or N; A 1 is a carbon atom or a nitrogen atom; A 2 is a carbon atom or a nitrogen atom; A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A 3 It's CR 4 ; R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Alkoxyamino, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Each of the alkoxyamino groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen and CN; or a salt or N-oxide thereof.

2. The compound of claim 1, wherein four A 3 It's CR 4 And an A 3 It's N.

3. The compound according to claim 1 or 2, wherein yes Preferably the four A 3 It's CR 4 .

4. The compound of claim 1 or 2, wherein yes Preferably the four A 3 It's CR 4 .

5. The compound of claim 1, wherein the five A 3 It's CR 4 .

6. A compound as claimed in any one of the preceding claims, wherein A 1 is a carbon atom and A 2 It's a nitrogen atom.

7. The compound of any one of claims 1 to 5, wherein A 1 is a carbon atom and A 2 It is a carbon atom.

8. The compound of any one of claims 1 to 5, wherein A 1 is a nitrogen atom and A 2 It is a carbon atom.

9. The compound of any one of claims 1 to 5, wherein A 1 is a nitrogen atom and A 2 It's a nitrogen atom.

10. The compound according to any one of claims 1 to 5, wherein ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (I), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

11. The compound of claim 10, wherein ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (I), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

12. The compound of any one of the preceding claims, wherein Ring W is a 5-8 membered heterocyclic ring or a 5-11 membered heteroaromatic ring, wherein each of the 5-8 membered heterocyclic ring or the 5-11 membered heteroaromatic ring is optionally substituted by one to four independently selected R 1 Substituent substitution A is N; A 1 is a carbon atom or a nitrogen atom; A 2 is a carbon atom or a nitrogen atom; A 3 Independently CR 4 or N, provided there are no more than three As 3 It is N; R 1 Selected from halogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkoxy and CN, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Each of the alkoxy groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; R 2a 、R 2b and R 2c independently selected from hydrogen, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkoxy and -NHC(O)C 1-6 alkyl; R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl and hydroxyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Each of the alkyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl and C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Each of the alkyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen and CN.

13. A composition comprising a fungicidally effective amount of a compound according to any one of claims 1 to 12.

14. The composition of claim 13, wherein the composition further comprises at least one compound selected from the group consisting of additional active ingredients, suitable formulation inerts, carriers, adjuvants, and any mixtures thereof.

15. A method for combating, preventing or controlling plant pathogenic diseases, the method comprising applying a fungicidally effective amount of a compound according to any one of claims 1 to 12, or a composition comprising a compound according to any one of claims 1 to 12, or a composition according to claim 13 or 14 to a plant pathogen, a locus of a plant pathogen, a plant susceptible to attack by a plant pathogen, or a plant propagation material thereof.

16. A compound having formula (II) Among them, ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (II), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; A 1 is a carbon atom or a nitrogen atom; A 2 is a carbon atom or a nitrogen atom; A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A 3 It's CR 4 ; R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and X is Cl, Br or I; or A compound having formula (XV) Among them, ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (XV), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; A 1 is a carbon atom or a nitrogen atom; A 2 is a carbon atom or a nitrogen atom; A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A 3 It's CR 4 ; R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; or A compound having formula (XXVI) Among them, ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (XXVI), and # represents the point of attachment to the imidazopyridine group represented by A. 3 The group forms the point of attachment of the ring, and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; A is CH or N; A 1 is a carbon atom or a nitrogen atom; A 2 is a carbon atom or a nitrogen atom; A 3 Independently CR 4 or N, provided there are no more than four As 3 N, preferably no more than three As 3 is N, preferably no more than two A 3 is N, preferably no more than one A 3 N, and more preferably five A 3 It's CR 4 ; R 1 Selected from halogen, hydroxy, amino, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and CN, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl and di-C 1-6 Each of the alkylaminocarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and wherein optionally two geminal R 1 Together with the carbon to which they are attached, they form a carbonyl group; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and R 4 are independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, halogen, CN, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl, C 1-6 Alkylcarbonyl and hydroxyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkoxy-C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxycarbonyl, C 1-6 Alkylaminocarbonyl, di-C 1-6 Alkylaminocarbonyl and C 1-6 Each of the alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

17. A compound having formula (XXII) Among them, ring W Selected from: wherein * represents the point of attachment to the imidazopyridine group in formula (XXII) and wherein R 11 Selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Alkynyl, wherein the C 1-6 Alkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 2-6 Alkenyl and C 2-6 Each of the alkynyl groups is optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxy, and CN; A 1 is a carbon atom or a nitrogen atom; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; and X is Cl, Br or I.

18. A compound having formula (XVII) Wherein A is CH or N; R 2a 、R 2b and R 2c are independently selected from hydrogen, hydroxy, halogen, CN, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl, C 1-6 Alkylsulfanyl, C 1-6 Alkylsulfinyl, C 1-6 Alkylsulfonyl, C 1-6 Alkoxy, amino and -NHC(O)C 1-6 alkyl; and preferably R 2a 、R 2b and R 2c are independently selected from hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy-C 1-6 Alkyl, C 3-6 Cycloalkyl-C 1-4 Alkyl and C 1-6 alkoxy; R 6 Selected from C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Alkoxyamino, wherein the C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, C 3-6 Cycloalkyl-C 1-6 Alkyl, C 1-6 Alkoxy C 1-6 Alkyl, C 1-6 Alkylamino, di-C 1-6 Alkylamino, C 1-6 Alkoxyamino and C 1-6 Alkyl C 1-6 Each of the alkoxyamino groups is optionally substituted with one to three substituents independently selected from halogen and CN; and X is Cl, Br or I.

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