Preparation method of fludioxonil with enhanced stability

Abstract

The invention relates to the technical field of agricultural bactericides, in particular to a fludioxonil stability-enhanced preparation method, which comprises the steps of stable additive screening, additive ratio optimization, step-by-step mixing process design, preparation performance test, formula parameter adjustment and long-term storage experiment. The stability of fludioxonil under the conditions of high temperature, high humidity and strong light is remarkably improved from two aspects of physicochemical property optimization and preparation process improvement through a multi-dimensional synergistic stabilization technology. The invention further provides a preparation system and device, and efficient preparation is achieved by carrying the method. The method can comprehensively cope with the influence of various environmental variables on the fludioxonil stability, simplifies the preparation process, reduces the production cost, and meets the requirements of modern agriculture on efficient and stable bactericides.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of pesticide preparation, and specifically relates to a preparation method for improving the stability of fludioxonil. BACKGROUND

[0002] Fludioxonil, as a broad-spectrum fungicide, has been widely used in agricultural production due to its high efficiency and low toxicity. However, its stability in practical application has always been one of the key factors restricting its effectiveness. Especially under different environmental conditions (such as temperature, humidity and light, etc.), the decomposition rate of fludioxonil increases, leading to reduced efficacy and even drug resistance. Therefore, how to improve the stability of fludioxonil has become the focus of current research.

[0003] According to the search, a seed dressing agent with the publication number CN103749452B was published on March 16, 2016. This patent solves the problem of gradually reduced fungicidal effect of fludioxonil by compounding fludioxonil with naphthoxyacetic acid and gibberellic acid, and enhances the stability of fludioxonil under different temperature, humidity and other external environmental conditions. However, this technical solution mainly relies on the synergistic effect between active ingredients to delay the occurrence of drug resistance, and does not improve the stability of fludioxonil from the physical and chemical properties of the preparation itself. In addition, although the adaptability of this seed dressing agent to environmental conditions has been improved, its long-term storage stability and performance under extreme conditions still have limitations, which may affect the actual application effect.

[0004] According to the search, an anti-photolysis suspending agent and its preparation method with the publication number CN114698640B were published on February 6, 2024. This patent significantly improves the light stability of the suspending agent of boscalid and fludioxonil by adding an anti-photolysis aid, so that it maintains a high fungicidal effect for a longer time after application. However, the focus of this technical solution is mainly on the improvement of anti-photolysis performance, and the control of other factors that may cause fludioxonil to be unstable (such as thermal degradation, hydrolysis, etc.) is limited. At the same time, the preparation process of this suspending agent involves the accurate proportioning of multiple functional aids, which may increase the production cost and technical threshold, thereby limiting the possibility of its large-scale promotion.

[0005] The above problems show that the existing fludioxonil-related preparations still have certain deficiencies in improving stability, especially in comprehensively addressing the influence of multiple environmental factors (such as light, heat, humidity, etc.) on the stability of fludioxonil. In addition, some technical solutions have complex preparation processes or high costs, which restrict the scope of their actual application. Therefore, the present application provides a preparation method for improving the stability of fludioxonil, which aims to optimize the formulation and process of the preparation, comprehensively improve the stability of fludioxonil under different environmental conditions, simplify the preparation process and reduce the cost, so as to meet the demand of modern agriculture for high-efficiency and stable fungicides. Summary of the Invention

[0006] This method innovatively adopts multidimensional collaborative stabilization technology scheme. Fludioxonil faces the problem of accelerated decomposition rate in agricultural applications, especially under different environmental conditions (such as temperature, humidity and illumination, etc.), and its stability is significantly affected. Conventional formulation adjustment method often relies on the improvement of a single factor, and is difficult to comprehensively deal with the impact of multiple environmental variables on the stability of fludioxonil. And the present invention, by introducing multidimensional collaborative stabilization technology, starts with two aspects of physicochemical property optimization and preparation process improvement, and constructs a new fludioxonil stability enhancement system.

[0007] Specifically, the process includes: first, screening and introducing a specific combination of stabilizing additives during the formulation design phase to inhibit the decomposition of fludioxonil under conditions of high temperature, high humidity, and strong light; second, precisely regulating the ratio of additives to ensure the formation of stable intermolecular forces between the components; then, adopting a step-by-step mixing process to fully disperse the additives and the fludioxonil active ingredient to further improve the uniformity and stability of the formulation; finally, experimentally verifying the performance of the formulation under different environmental conditions, optimizing the final formulation parameters, and completing the design of the preparation process.

[0008] The present invention is generally achieved by the following steps:

[0009] A preparation method of fludioxonil with enhanced stability, comprising the following steps:

[0010] Step 1: Screening Stabilizing Agents: Select agents with antioxidant, anti-photolysis, and thermal stabilization properties, including but not limited to organosilicon compounds, fatty acid esters, and metal ion chelators. Single-factor experiments are conducted to evaluate the effect of each agent on the decomposition rate of fludioxonil and determine the optimal agent type and initial ratio range.

[0011] Step 2: Optimize the additive ratio: Based on the screening results from Step 1, an orthogonal experimental design was used to set different additive ratios and investigate their effects on fludioxonil stability. The optimal additive ratio was determined using decomposition rate and storage stability as evaluation indicators.

[0012] Step 3: Design a step-by-step mixing process: Based on their physical and chemical properties, the excipients are categorized into hydrophilic and hydrophobic types, each with its own unique mixing method. Hydrophilic excipients are first dissolved in an appropriate amount of solvent and then mixed with the active ingredient, fludioxonil. Hydrophobic excipients are evenly distributed throughout the formulation using high-speed shear dispersion technology. Temperature and stirring speed are controlled during the mixing process to prevent degradation of the active ingredient due to mechanical stress.

[0013] Step 4: Preparation Performance Testing: The prepared preparation was tested under simulated environmental conditions, including high temperature (50°C), high humidity (90% relative humidity), and strong light (UV irradiation). The decomposition rate and bactericidal efficacy of the preparation under different conditions were recorded to assess its overall stability.

[0014] Step 5: Adjust formulation parameters: Based on the test results from Step 4, fine-tune the types and ratios of additives to further optimize formulation performance. If the formulation is found to be unstable under certain environmental conditions, increase the proportion of the corresponding functional additives or adjust the mixing process parameters accordingly.

[0015] Step 6: Long-term storage testing: Optimized formulation samples are placed at room temperature for long-term storage testing, with regular testing of active ingredient content and bactericidal efficacy. If accelerated decomposition is observed during storage, the excipient ratio and mixing process are reassessed until long-term storage requirements are met.

[0016] Furthermore, the specific method for screening the stabilizing agent in step 1) is as follows: for each candidate agent, a certain concentration is added to a standard solution containing fludioxonil to prepare a test sample. Subsequently, the test samples are placed under high temperature (60°C), high humidity (relative humidity 95%) and strong light (300W ultraviolet light irradiation) conditions for 72 hours. The residual amount of fludioxonil is determined by high performance liquid chromatography, and the decomposition rate is calculated. The agent with the lowest decomposition rate and moderate cost is selected as the preferred agent.

[0017] Furthermore, the step 3) step-by-step mixing process design includes the following details:

[0018] ① Dissolution of the hydrophilic additive: Add the hydrophilic additive to deionized water, heat to 40°C, and stir at 300 rpm until completely dissolved. Then, slowly add the dissolved solution to the mixed system containing the active ingredient fludioxonil and continue stirring for 10 to 15 minutes to ensure uniform dispersion.

[0019] ② Dispersion of hydrophobic additives: Add the hydrophobic additive to an appropriate amount of organic solvent, premix evenly, and pass through a high-speed shearing device (speed 8000 rpm for 5 minutes) to form a uniform emulsion. Subsequently, the emulsion is slowly added to the mixed system containing the active ingredient fludioxonil and stirred for 5 to 10 minutes to ensure full dispersion.

[0020] ③ Temperature control during the mixing process: The entire mixing process must be maintained within a range of 25°C to 35°C to avoid decomposition of fludioxonil due to excessive temperatures. At the same time, the stirring speed must be dynamically adjusted according to the viscosity characteristics of the additive to ensure mixing uniformity.

[0021] Furthermore, the specific method of adjusting the recipe parameters in step 5) is as follows:

[0022] ① Decomposition rate analysis: Based on the test results in step 4, plot the decomposition curves of fludioxonil under different environmental conditions and analyze the trend of its decomposition rate over time. If the decomposition rate is significantly accelerated under a certain condition, increase the proportion of the corresponding functional additive first.

[0023] ② Bactericidal efficacy evaluation: The plate count method is used to determine the bactericidal efficacy of the preparation under different conditions, and its inhibition rate against the target pathogens is recorded. If the bactericidal efficacy decreases significantly, the adjuvant ratio and mixing process need to be re-evaluated to ensure that the bactericidal efficacy is not affected.

[0024] ③ Parameter optimization strategy: Based on the comprehensive evaluation results of decomposition rate and bactericidal effect, adjust the type and ratio of additives. For example, if the decomposition rate is higher under high temperature conditions, increase the proportion of heat-stabilizing additives; if the decomposition rate is higher under high humidity conditions, increase the proportion of anti-hydrolysis additives.

[0025] Furthermore, the specific method for the long-term storage experiment in step 6) is as follows: Samples of the optimized formulation are dispensed into sealed containers and placed in a constant temperature and humidity environment at 25°C ± 2°C and 60% ± 5% relative humidity. Samples are collected every 30 days to test the active ingredient content and bactericidal efficacy. If the decomposition rate exceeds 10% or the bactericidal efficacy decreases by more than 20%, the formulation parameters are readjusted until the long-term storage requirements are met.

[0026] A fludioxonil stability-enhanced preparation system comprises a raw material input module, an auxiliary agent screening module, a mixing process module, a performance testing module, a parameter adjustment module and a storage experiment module, wherein the modules are sequentially connected by data communication.

[0027] The raw material input module executes the step 1;

[0028] The auxiliary agent screening module executes the step 2;

[0029] The mixing process module performs the step 3;

[0030] The performance testing module runs step 4;

[0031] The parameter adjustment module executes the step 5;

[0032] The storage experiment module runs the step 6.

[0033] A preparation device for fludioxonil with enhanced stability, the device being equipped with the system.

[0034] The present invention has the following advantages over the prior art: Fludioxonil faces the problem of accelerated decomposition rate in practical applications, especially under different environmental conditions, where its stability is significantly affected. The present invention comprehensively improves the stability of fludioxonil under high temperature, high humidity, and strong light conditions by introducing multi-dimensional synergistic stabilization technology, from adjuvant screening and ratio optimization to mixing process design. At the same time, the present invention simplifies the preparation process and reduces production costs, thereby meeting the demand for efficient and stable fungicides in modern agriculture. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 Schematic diagram of the process for preparing fludioxonil with enhanced stability according to the present invention;

[0036] Figure 2 A detailed flow chart designed for the step-by-step mixing process;

[0037] Figure 3 Schematic diagram of the module connection of the fludioxonil stability enhancement preparation system.

[0038] The accompanying drawings are marked as follows: 1. Raw material input module; 2. Auxiliary agent screening module; 3. Mixing process module; 4. Performance testing module; 5. Parameter adjustment module; 6. Storage experiment module. DETAILED DESCRIPTION

[0039] The present invention provides a preparation method of fludioxonil with enhanced stability, a system and a device thereof, Figure 1 To the attached Figure 3 The specific implementation method is described in detail. The technical solution involved in this embodiment includes the collaborative operation process between the raw material input module 1, the auxiliary agent screening module 2, the mixing process module 3, the performance testing module 4, the parameter adjustment module 5 and the storage experiment module 6, and its operation process and implementation method are described through specific steps.

[0040] In actual application, the preparation and input of the initial raw materials are first completed through the raw material input module 1. This module is responsible for preliminarily configuring the active ingredient of fludioxonil and the candidate adjuvants according to the preset ratio and transmitting them to the adjuvant screening module 2. The adjuvant screening module 2 runs the specific content of step 1, that is, the operation of stabilizing the adjuvant screening. Figure 1As shown, after the auxiliary agent screening module 2 receives the raw materials from the raw material input module 1, it begins to test the candidate auxiliary agents one by one. Each candidate auxiliary agent is added to a standard solution containing diclofentonil at a certain concentration to form a test sample. Subsequently, the test samples are placed under high temperature 60°C, high humidity 95% relative humidity and strong light 300W ultraviolet lamp irradiation conditions for continuous exposure for 72 hours. During this process, the residual amount of diclofentonil is determined by high performance liquid chromatography and the decomposition rate is calculated. Finally, the auxiliary agent with the lowest decomposition rate and moderate cost is selected as the preferred auxiliary agent. The screening results of this stage are transmitted to the mixing process module 3 via data communication to provide a basis for subsequent operations.

[0041] The specific content of the operation step 3 of the mixing process module 3, that is, the operation of the step-by-step mixing process design, can be found in the attached Figure 2 . According to the physicochemical properties of the additives, the mixing process module 3 divides the additives into two categories: hydrophilic and hydrophobic, and adopts different treatment methods. For hydrophilic additives, they are added to deionized water, heated in the range of 40°C to 50°C, and stirred at a speed of 200rpm to 300rpm until completely dissolved. Subsequently, the dissolved solution is slowly added to the mixed system containing the active ingredient of fludioxonil, and stirring is continued for 10 minutes to 15 minutes to ensure uniform dispersion. For hydrophobic additives, they are first added to an appropriate amount of organic solvent for premixing, and then processed at a speed of 8000rpm to 12000rpm through a high-speed shearing device for 3 minutes to 5 minutes to form a uniform emulsion. The emulsion is slowly added to the mixed system containing the active ingredient of fludioxonil, and stirring is continued for 5 minutes to 10 minutes to ensure sufficient dispersion. The entire mixing process needs to be maintained in the range of 25°C to 35°C to avoid decomposition of fludioxonil due to excessive temperature. At the same time, the stirring speed is dynamically adjusted according to the viscosity characteristics of the additive to ensure mixing uniformity. After mixing is completed, the formulation sample is transferred to the performance testing module 4.

[0042] Performance testing module 4 performs the specific operations of step 4, namely, the preparation performance test. This module subjects the prepared preparation to simulated environmental conditions for testing, including high temperature of 50°C, high humidity of 90% relative humidity, and strong ultraviolet light exposure. During the test, the decomposition rate and bactericidal effect of the preparation under different conditions are recorded to evaluate its overall stability. Performance testing module 4 determines the bactericidal effect of the preparation under different conditions using the plate count method and records its inhibition rate against the target pathogens. The test results are transmitted to parameter adjustment module 5 via data communication for further optimization of the formulation parameters.

[0043] The parameter adjustment module 5 runs the specific content of step 5, i.e., the operation of adjusting the formula parameters. According to the test results provided by the performance test module 4, the decomposition curve of fludioxonil under different environmental conditions is drawn, and the trend of its decomposition rate over time is analyzed. If the decomposition rate is significantly accelerated under a certain condition, priority is given to increasing the proportion of the corresponding functional additives. For example, if the decomposition rate is higher under high temperature conditions, the proportion of heat-stable additives is increased; if the decomposition rate is higher under high humidity conditions, the proportion of anti-hydrolysis additives is increased. In addition, when the bactericidal effect evaluation results show that the bactericidal effect has decreased significantly, the additive ratio and mixing process need to be re-evaluated to ensure that the bactericidal effect is not affected. The optimized formula parameters are transmitted to the storage experiment module 6 via data communication.

[0044] The storage experiment module 6 runs the specific content of step 6, that is, the operation of the long-term storage experiment. This module divides the optimized preparation samples into sealed containers and places them in a constant temperature and humidity environment of 25℃±2℃ and relative humidity of 60%±5% for long-term storage experiments. Samples are taken every 30 days to test the content of active ingredients and the bactericidal effect. If it is found that the decomposition rate exceeds 10% or the bactericidal effect decreases by more than 20%, the formula parameters are readjusted until the long-term storage requirements are met. The final results of the storage experiment module 6 are fed back to the raw material input module 1 to form a closed-loop control to ensure the stability and reliability of the entire preparation system.

[0045] Combined with attachment Figure 3 As can be seen, the raw material input module 1, the adjuvant screening module 2, the mixing process module 3, the performance testing module 4, the parameter adjustment module 5, and the storage experiment module 6 are connected via data communication to form a complete fludioxonil stability enhancement preparation system. The collaborative relationship between each module is clear and well-defined, and can efficiently complete the entire process from raw material preparation to final formulation optimization. The raw material input module 1 provides the basic raw materials for the entire system. The adjuvant screening module 2 determines the optimal adjuvant type and its preliminary ratio range by screening candidate adjuvants. The mixing process module 3 ensures sufficient dispersion of the adjuvant and the fludioxonil active ingredient through step-by-step mixing process design. The performance testing module 4 tests the stability of the formulation by simulating environmental conditions. The parameter adjustment module 5 optimizes the formulation parameters based on the test results. The storage experiment module 6 verifies the long-term stability of the formulation through long-term storage experiments. The data communication between the modules ensures the efficient operation and precise control of the entire system.

[0046] In practical application scenarios, the preparation method of the present invention can be widely applied in the production of agricultural fungicides. For example, in high-temperature and high-humidity areas, the fludioxonil preparation prepared by the present invention can maintain high stability under complex environments, thereby extending its effective shelf life. In addition, the preparation system and device of the present invention can achieve large-scale production through automated control, reducing errors caused by manual operation and improving production efficiency.

[0047] In order to better enable relevant personnel in this technical field to fully understand and implement the present invention, the specific implementation principle of the present invention is further supplemented below in combination with a specific application scenario.

[0048] In high temperature and high humidity areas, the stability problem of fludioxonil preparations is particularly prominent. To solve this problem, the raw material input module 1 first preliminarily mixes the fludioxonil active ingredient with a variety of candidate adjuvants according to a preset ratio and transmits it to the adjuvant screening module 2. The adjuvant screening module 2 Figure 1 The process shown in the figure tests each incoming raw material for decomposition rate under conditions of high temperature (60°C), high humidity (95%), and strong 300W UV light. For example, an organosilicon compound additive exhibits excellent thermal stability under high temperature conditions, while fatty acid esters significantly inhibit the hydrolysis of fludioxonil in high humidity. After determining the residual amount of fludioxonil using high-performance liquid chromatography, the additive with the lowest decomposition rate and moderate cost is selected as the preferred combination, and the screening results are transmitted to the mixing process module 3.

[0049] Mixing process module 3 according to the attached Figure 2 The step-by-step mixing process design divides the additives into two categories, hydrophilic and hydrophobic, and treats them separately. For hydrophilic additives, they are added to deionized water, heated in the range of 40°C to 50°C, and stirred at a speed of 200rpm to 300rpm until completely dissolved. The dissolved liquid is slowly added to the mixed system containing the active ingredient of fludioxonil to ensure uniform dispersion. For hydrophobic additives, they are first premixed with an appropriate amount of organic solvent, and then processed using high-speed shearing equipment at a speed of 8000rpm to 12000rpm for 3 minutes to 5 minutes to form a uniform emulsion. Subsequently, the emulsion is slowly added to the mixed system and stirred for 5 minutes to 10 minutes to ensure sufficient dispersion. The entire mixing process is strictly controlled in the range of 25°C to 35°C to avoid decomposition of fludioxonil due to excessive temperature. The stirring speed is dynamically adjusted according to the viscosity characteristics of the additive to ensure mixing uniformity.

[0050] Performance Testing Module 4 tests the prepared formulation under simulated environmental conditions. For example, at a high temperature of 50°C, high-performance liquid chromatography revealed that the addition of a thermal stabilizer reduced the decomposition rate of the formulation by approximately 30%. Under high humidity conditions of 90% relative humidity, the anti-hydrolysis agent significantly slowed the hydrolysis rate of fludioxonil. Furthermore, the plate count method was used to determine the inhibitory rate of the formulation against target pathogens, verifying that its bactericidal efficacy was intact. The test results were transmitted to Parameter Adjustment Module 5 via data communication.

[0051] The parameter adjustment module 5 plots a decomposition curve based on the data from the performance testing module 4, analyzing the temporal trend of the decomposition rate. For example, if the decomposition rate is higher under high temperature conditions, the proportion of heat stabilizing agents is increased; if the decomposition rate is higher under high humidity conditions, the proportion of anti-hydrolysis agents is increased. Furthermore, if the bactericidal effect decreases significantly, the additive ratio and mixing process are reassessed to ensure that the bactericidal effect is not affected. The optimized formulation parameters are transmitted to the storage experiment module 6.

[0052] The storage experiment module 6 divides the optimized preparation samples into sealed containers and places them in a constant temperature and humidity environment of 25℃±2℃ and relative humidity of 60%±5% for long-term storage experiments. Samples are taken every 30 days to test their active ingredient content and bactericidal effect. For example, after 180 days of storage, the active ingredient content of the preparation remains above 90% of the initial value, and the bactericidal effect decreases by less than 10%, indicating that its long-term stability meets the requirements. If it is found that the decomposition rate exceeds 10% or the bactericidal effect decreases by more than 20%, the formula parameters are readjusted until the long-term storage requirements are met.

[0053] Combined with attachment Figure 3 As can be seen, the raw material input module 1, the additive screening module 2, the mixing process module 3, the performance testing module 4, the parameter adjustment module 5, and the storage experiment module 6 are connected through data communication, forming a closed-loop control. For example, if the storage experiment module 6 detects that the formulation performs poorly under extreme conditions, feedback information is transmitted to the raw material input module 1, which adjusts the initial additive type or ratio range to further optimize the formulation performance.

[0054] In actual production, the preparation system of the present invention can achieve large-scale production through automated control. For example, the high-speed shearing device and the stirring device in the mixing process module 3 can be uniformly regulated by a controller to ensure the mixing uniformity of each batch of preparations. At the same time, the data acquisition and analysis process of the performance test module 4 and the storage experiment module 6 can be completed by sensors and computers, significantly reducing manual operation errors and improving production efficiency. This systematic preparation method not only improves the stability of the fludioxonil preparation under complex environments, but also simplifies the preparation process, reduces production costs, and provides an efficient and stable fungicide solution for modern agriculture.

[0055] Any content not described in detail in the specification belongs to the prior art known to those skilled in the art, and the model parameters of each device are not specifically limited, and conventional devices can be used. In this technical solution, electrical control components not mentioned are not shown in the figures because they belong to the prior art and will not be described here.

[0056] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A method for preparing fludioxonil with enhanced stability, characterized in that: The method comprises the following steps: Step 1: Screening of stabilizing agents: Selecting agents with antioxidant, anti-photolysis, and thermal stabilization properties, including organosilicon compounds, fatty acid esters, and metal ion chelating agents; adding the candidate agents at a specific concentration to a standard solution containing fludioxonil to form a test sample; exposing the test sample to 300-watt ultraviolet light at 60 degrees Celsius, 95% relative humidity, and for 72 hours; determining the residual amount of fludioxonil by high-performance liquid chromatography, calculating the decomposition rate, and selecting the agent with the lowest decomposition rate and moderate cost as the preferred agent; Step 2: Optimize the adjuvant ratio: Based on the screening results of step 1, an orthogonal experimental design was used to set the ratio combinations of different adjuvants and investigate their effects on the stability of fludioxonil. The optimal adjuvant ratio was determined using decomposition rate and storage stability as evaluation indicators. Step 3, step-by-step mixing process design: According to the physicochemical properties of the additives, the additives are divided into two categories: hydrophilic and hydrophobic, and different mixing methods are adopted for each additive; for the hydrophilic additive, it is dissolved in deionized water, heated in the range of 40 degrees Celsius to 50 degrees Celsius and stirred at a speed of 200 to 300 revolutions per minute until completely dissolved, and then the dissolved solution is slowly added to the mixed system containing the fludioxonil active ingredient, and stirring is continued for 10 to 15 minutes; for the hydrophobic additive, it is added to an appropriate amount of organic solvent and premixed uniformly, and then processed by a high-speed shearing device at a speed of 8000 to 12000 revolutions per minute for 3 to 5 minutes to form a uniform emulsion, and then the emulsion is slowly added to the mixed system containing the fludioxonil active ingredient, and stirring is continued for 5 to 10 minutes; the entire mixing process needs to be maintained in the range of 25 to 35 degrees Celsius to avoid decomposition of fludioxonil due to excessive temperature; Step 4: Preparation Performance Testing: The prepared preparation was placed under simulated environmental conditions for testing, including 50 degrees Celsius, 90% relative humidity, and UV irradiation; the decomposition rate and bactericidal effect of the preparation under different conditions were recorded; Step 5: Adjustment of formulation parameters: Based on the test results of step 4, plot the decomposition curves of fludioxonil under different environmental conditions and analyze the trend of its decomposition rate over time. If the decomposition rate is significantly accelerated under a certain condition, increasing the proportion of the corresponding functional additive is a priority. If the bactericidal effect decreases significantly, re-evaluate the adjuvant ratio and mixing process; Step 6. Long-term storage experiment: The optimized formulation samples were divided into sealed containers and placed in a constant temperature and humidity environment of 25 degrees Celsius ± 2 degrees Celsius and 60% ± 5% relative humidity. Samples were taken every 30 days to test the active ingredient content and bactericidal effect. If the decomposition rate exceeded 10% or the bactericidal effect decreased by more than 20%, the formulation parameters were readjusted.

2. The method according to claim 1, characterized in that In step 1, the concentration of the candidate adjuvant ranges from 0.1% to 5%.

3. The method according to claim 1, characterized in that In step 3, the dissolution process of the hydrophilic additive needs to be heated in the range of 40 degrees Celsius to 50 degrees Celsius and stirred at a speed of 200 to 300 revolutions per minute until it is completely dissolved.

4. The method according to claim 1, wherein In step 3, the dispersion process of the hydrophobic additive needs to be processed by a high-speed shearing device at a speed of 8000 to 12000 rpm for 3 to 5 minutes to form a uniform emulsion.

5. The method according to claim 1, wherein In step 5, if the decomposition rate is higher under high temperature conditions, the proportion of the heat stabilizing agent is increased; if the decomposition rate is higher under high humidity conditions, the proportion of the anti-hydrolysis agent is increased.

6. A preparation system for fludioxonil with enhanced stability, characterized in that: The system comprises a raw material input module (1), an auxiliary agent screening module (2), a mixing process module (3), a performance testing module (4), a parameter adjustment module (5) and a storage experiment module (6), wherein the modules are sequentially connected with data communication; The raw material input module (1) executes step 1 described in claim 1; The auxiliary agent screening module (2) performs step 2 of claim 1; The mixing process module (3) performs step 3 of claim 1; The performance testing module (4) executes step 4 of claim 1; The parameter adjustment module (5) executes step 5 of claim 1; The storage experiment module (6) runs step 6 described in claim 1.

7. A preparation device for fludioxonil with enhanced stability, characterized in that: The device is equipped with the system according to claim 6.

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