Traditional Chinese medicine incense composition and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine incense composition and a preparation method thereof, and the traditional Chinese medicine incense composition comprises the following raw materials in parts by weight: 10-15 parts of sandalwood, 5-10 parts of safflower, 10-15 parts of agilawood, 2-4 parts of perilla leaf, 10-15 parts of elsholtzia calyx extract, 10-12 parts of citrus aurantium extract and 8-10 parts of thalictrum aquilegifolium extract. All the raw material components are compatible with one another, so that the air quality can be improved, air is purified, dirt is removed, gloomy is expelled, mood is regulated and pacified, mental conditions are improved, various plague is prevented, cold is prevented, and the effect of enhancing human immunity is achieved. The extraction mode of the extract is efficient and environmentally friendly, effective substances can be rapidly extracted, the purity and activity of the components are ensured, no other substance residues exist, and the final incense is high in safety, natural and lasting in fragrance, harmless to the body and good in application value.

Description

TECHNICAL FIELD

[0001] The present application relates to incense technology field, in particular to a traditional Chinese medicine incense composition and a preparation method thereof. BACKGROUND

[0002] Incense is a traditional incense product in China, with a long history and culture. The traditional production method is to mix spices, aggregates and binding materials and then press them to obtain incense. The health care effect of incense is to use the aroma of pure natural medicine and the healing ability, through the absorption of human olfactory organs or skin, through the nerve and circulatory system to produce effect, so that the body, mind and spirit of human being achieve balance and unity.

[0003] Traditional Chinese medicine incense can emit fresh and elegant fragrance, effectively remove indoor odor, and beautify the living environment. Some traditional Chinese medicine incense such as agarwood and sandalwood can make people feel happy and relaxed because of its elegant and elegant fragrance. Many traditional Chinese medicinal materials have unique pharmacological effects, which can volatilize the medicinal properties through incense, so as to achieve the purpose of health care, disease prevention and treatment. For example, some traditional Chinese medicine incense has the effects of soothing the mind, regulating endocrine and improving sleep. Influenza is a common disease that harms people's health and is easily transmitted. In the face of cold, most of them are prevented or treated by oral or intravenous injection. Some patients are infected again because of the transmission of viruses in the air.

[0004] Therefore, it has practical significance to develop a traditional Chinese medicine incense which can improve air quality, wake up the mind, sleep well and prevent cold. SUMMARY

[0005] In view of this, the present application provides a traditional Chinese medicine incense composition and a preparation method thereof.

[0006] The technical scheme of the present application is as follows: A traditional Chinese medicine incense composition, according to weight parts, comprises the following raw materials: 10-15 parts of sandalwood, 5-10 parts of safflower, 10-15 parts of agarwood, 2-4 parts of perilla leaf, 10-15 parts of elsholtzia calycosa extract, 10-12 parts of oreocnide pedunculata extract and 8-10 parts of pterospora extract. Further, the preparation method of the elsholtzia calycosa extract is as follows: The elsholtzia calycosa is crushed and placed in a supercritical CO2 extraction device for extraction, and then concentrated under reduced pressure to obtain the elsholtzia calycosa extract.

[0007] Further, the supercritical CO2 extraction is first extracted at 35-45℃ and 15-25MPa for 30-40min, and then extracted at 50-60℃ and 30-40MPa for 15-25min.

[0008] Furthermore, the preparation method of the jacaranda extract is as follows: The orange-yellow hazelnut flower is crushed, added into a buffer solution, extracted, and concentrated under reduced pressure to obtain the orange-yellow hazelnut flower extract.

[0009] Furthermore, the buffer solution is any one of a lactic acid buffer solution, a citric acid buffer solution, a phosphate buffer solution, and a malic acid buffer solution; the material-liquid ratio of the orange-yellow hibiscus flower to the buffer solution is 1:10-20 g / mL; and the extraction is performed at 40-60° C. for 1-2 hours.

[0010] Furthermore, the preparation method of the samarassa extract is as follows: The samarachnid herb was crushed, added into an ethanol solution, and extracted by microwave heating. The extract was filtered through an ultrafiltration membrane with a molecular weight cutoff of less than 3000 Da and concentrated under reduced pressure to obtain the samarachnid herb extract.

[0011] Furthermore, the concentration of the ethanol solution is 40-60% v / v; the solid-liquid ratio of the winged thrush to the ethanol solution is 1:6-10 g / mL; and the microwave heating extraction is performed at 400-500W and 60-70°C for 40-60 minutes.

[0012] A method for preparing a Chinese medicine incense composition, comprising the following steps: Grind and sieve sandalwood, safflower, agarwood and perilla leaves, grind and sieve Elsholtzia calyx extract, Rubus aurantii extract and Thalictrum lucidum extract, add adhesive and mix evenly, add water and stir into a fragrant ball, fill into a fragrance making machine, press into shape through a mold, dry naturally in the shade, and store in a sealed container.

[0013] Furthermore, the grinding and screening is through an 80-120 mesh sieve.

[0014] Furthermore, the adhesive is elm bark powder, and the added amount is 8%-10% of the total amount of the traditional Chinese medicine.

[0015] Sandalwood: Promotes qi and warms the middle, stimulates appetite and relieves pain. Safflower: Promotes blood circulation and menstruation, dissipates blood stasis and relieves pain. Agarwood: Promotes qi and relieves pain, warms the middle and stops vomiting, promotes qi and relieves asthma. Perilla leaf: Relieves exterior symptoms and dispels cold, promotes qi and harmonizes the stomach. Elsholtzia calycifolia: Induces sweating, relieves heat, promotes dampness, and promotes diuresis. Rubus citrifolia: Clears heat and detoxifies; promotes blood circulation and relieves pain. Thalictrum lucidum: Clears heat and detoxifies.

[0016] Compared with the prior art, the present invention has the following beneficial effects: The Chinese medicinal incense of the present invention is a combination of sandalwood, safflower, agarwood, perilla leaf, Elsholtzia calycifolia extract, Rubus aurantii extract, and Thalictrum serrata extract. The incense has the effects of clearing away heat and detoxifying, invigorating the mind and calming the spirit, promoting sleep, and preventing colds. Specifically, the incense improves air quality, purifies the air, removes impurities, dispels bad luck, regulates and soothes emotions, improves mental state, and prevents various plagues. It is particularly effective in preventing colds and enhancing human immunity. The incense of the present invention has a natural and long-lasting fragrance, is harmless to the body, and has good application value.

[0017] The extraction method of the extract of the present invention is efficient and environmentally friendly, can quickly extract effective substances, ensure the purity and activity of the components, and will not leave any residues of other substances, so that the final incense is highly safe. DETAILED DESCRIPTION

[0018] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0019] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0020] Unless otherwise specified, the materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources.

[0021] The adhesive of the invention is elm bark powder, and the added amount is 8%-10% of the total amount of the traditional Chinese medicine.

[0022] Example 1 A traditional Chinese medicine incense composition comprises the following raw materials in parts by weight: 13 parts of sandalwood, 8 parts of safflower, 13 parts of agarwood, 3 parts of perilla leaves, 13 parts of esculenta calycifolia extract, 11 parts of euphorbia milii extract, and 9 parts of thrush extract. The preparation method of the above-mentioned Elsholtzia calyx extract is as follows: The Elsholtzia calycifolia was crushed and placed in a supercritical CO2 extraction device. The extraction was first performed at 40°C and 20 MPa for 35 minutes, and then at 55°C and 35 MPa for 20 minutes. The extract was concentrated under reduced pressure to obtain the Elsholtzia calycifolia extract.

[0023] The preparation method of the above-mentioned orange-yellow hibiscus flower extract is as follows: The orange-yellow jasmine flower was crushed, added into a lactic acid buffer solution at a solid-liquid ratio of 1:15 g / mL, extracted at 50° C. for 1.5 h, and concentrated under reduced pressure to obtain the orange-yellow jasmine flower extract.

[0024] The preparation method of the above-mentioned samarass extract is as follows: The samarachnid herb was crushed and added to a 50% v / v ethanol solution at a solid-liquid ratio of 1:8 g / mL. The solution was extracted at 450W and 65°C for 50 minutes. The extract was filtered through an ultrafiltration membrane with a molecular weight cutoff of less than 3000Da and concentrated under reduced pressure to obtain a samarachnid herb extract.

[0025] A method for preparing a Chinese medicine incense composition, comprising the following steps: Grind sandalwood, safflower, agarwood and perilla leaves through a 100-mesh sieve, grind the Elsholtzia calyx extract, the Euphorbia milii extract and the Thalictrum lucidum extract through a 100-mesh sieve, add adhesive and mix evenly, add water and stir to form a fragrant ball, fill it into a fragrance making machine, press it into a mold, dry it naturally in the shade, and store it in a sealed container.

[0026] Example 2 A traditional Chinese medicine incense composition comprises the following raw materials in parts by weight: 10 parts of sandalwood, 5 parts of safflower, 10 parts of agarwood, 2 parts of perilla leaves, 10 parts of esculenta calycifolia extract, 10 parts of euphorbia milii extract, and 8 parts of thrush extract. The preparation method of the above-mentioned Elsholtzia calyx extract is as follows: The Elsholtzia calycifolia was crushed and placed in a supercritical CO2 extraction device. The extraction was first performed at 35°C and 15MPa for 30min, and then at 50°C and 30MPa for 15min. The extract was concentrated under reduced pressure to obtain the Elsholtzia calycifolia extract.

[0027] The preparation method of the above-mentioned orange-yellow hibiscus flower extract is as follows: The orange-yellow jasmine flower was crushed, added into a lactic acid buffer solution at a solid-liquid ratio of 1:10 g / mL, extracted at 40° C. for 1 h, and concentrated under reduced pressure to obtain the orange-yellow jasmine flower extract.

[0028] The preparation method of the above-mentioned samarass extract is as follows: The samarachnid herb was crushed and added to a 40% v / v ethanol solution at a solid-liquid ratio of 1:6 g / mL. The solution was extracted at 400 W and 60° C. for 40 min. The extract was filtered through an ultrafiltration membrane with a molecular weight cutoff of less than 3000 Da and concentrated under reduced pressure to obtain a samarachnid herb extract.

[0029] A method for preparing a Chinese medicine incense composition, comprising the following steps: Grind sandalwood, safflower, agarwood and perilla leaves through a 120-mesh sieve, grind the Elsholtzia calyx extract, the Rubus aurantii extract and the Thalictrum serrata extract through a 120-mesh sieve, add adhesive and mix evenly, add water and stir into a fragrant ball, fill it into a fragrance making machine, press it into a mold, dry it naturally in the shade, and store it in a sealed container.

[0030] Example 3 A traditional Chinese medicine incense composition comprises the following raw materials in parts by weight: 15 parts of sandalwood, 10 parts of safflower, 15 parts of agarwood, 4 parts of perilla leaves, 15 parts of esculenta calycifolia extract, 12 parts of euphorbia milii extract, and 10 parts of thrush extract. The preparation method of the above-mentioned Elsholtzia calyx extract is as follows: The Elsholtzia calycifolia was crushed and placed in a supercritical CO2 extraction device. The extraction was first performed at 45°C and 25 MPa for 40 min, and then at 60°C and 40 MPa for 25 min. The extract was concentrated under reduced pressure to obtain the Elsholtzia calycifolia extract.

[0031] The preparation method of the above-mentioned orange-yellow hibiscus flower extract is as follows: The orange-yellow jasmine flower was crushed, added into a lactic acid buffer solution at a solid-liquid ratio of 1:20 g / mL, extracted at 60° C. for 2 h, and concentrated under reduced pressure to obtain the orange-yellow jasmine flower extract.

[0032] The preparation method of the above-mentioned samarass extract is as follows: The samarachnid herb was crushed and added to a 60% v / v ethanol solution at a solid-liquid ratio of 1:10 g / mL. The solution was extracted at 500W and 70°C for 60 minutes. The extract was filtered through an ultrafiltration membrane with a molecular weight cutoff of less than 3000Da and concentrated under reduced pressure to obtain a samarachnid herb extract.

[0033] A method for preparing a Chinese medicine incense composition, comprising the following steps: Grind sandalwood, safflower, agarwood and perilla leaves through an 80-mesh sieve, grind the Elsholtzia calyx extract, the Euphorbia milii extract and the Thalictrum lucidum extract through an 80-mesh sieve, add adhesive and mix evenly, add water and stir into a fragrant ball, fill it into a fragrance making machine, press it into a mold, dry it naturally in the shade, and store it in a sealed container.

[0034] Comparative Example 1 This comparative example differs from Example 1 in that the amounts of raw materials used are different, and the rest are the same as Example 1.

[0035] That is, the Chinese medicine incense composition of this comparative example includes the following raw materials, in parts by weight: 18 parts of sandalwood, 12 parts of safflower, 8 parts of agarwood, 5 parts of perilla leaves, 8 parts of calyx sylvestris extract, 8 parts of orange-yellow jade flower extract, and 5 parts of winged thrush extract. Comparative Example 2 This comparative example differs from Example 1 in that: the extract of Elsholtzia calycifolia is missing, and the amount of the missing substance is distributed to other substances according to the proportion of other substances. Other aspects are consistent with Example 1.

[0036] Comparative Example 3 The comparative example differs from example 1 in that the extract of Pogostemon glaucus is absent, the amount of the absent substance is distributed to the other substances according to the proportion of the other substances, and the other conditions are the same as in example 1.

[0037] Comparative example 4 The comparative example differs from example 1 in that the extract of Pteryxia hispidula is absent, the amount of the absent substance is distributed to the other substances according to the proportion of the other substances, and the other conditions are the same as in example 1.

[0038] Comparative example 5 The comparative example differs from example 1 in that the extraction method of the extract of Pogostemon glaucus, the extract of Pogostemon aurantiacus and the extract of Pteryxia hispidula is water extraction, and the other conditions are the same as in example 1.

[0039] The preparation method of the extract of Pogostemon glaucus in the traditional Chinese medicine incense composition of the present application is as follows: The Pogostemon glaucus is crushed, deionized water is added according to a solid-liquid ratio of 1:10 g / mL, and extraction is carried out at 80°C for 4h. The extract solution is concentrated under reduced pressure to obtain the extract of Pogostemon glaucus.

[0040] The preparation method of the extract of Pogostemon aurantiacus is as follows: The Pogostemon aurantiacus is crushed, deionized water is added according to a solid-liquid ratio of 1:10 g / mL, and extraction is carried out at 80°C for 4h. The extract solution is concentrated under reduced pressure to obtain the extract of Pogostemon aurantiacus.

[0041] The preparation method of the extract of Pteryxia hispidula is as follows: The Pteryxia hispidula is crushed, deionized water is added according to a solid-liquid ratio of 1:10 g / mL, and extraction is carried out at 80°C for 4h. The extract solution is concentrated under reduced pressure to obtain the extract of Pteryxia hispidula.

[0042] Test example 90 ICR male mice with a body weight of 20±2g were selected, and the mice were allowed to freely eat and drink water for 5 days of adaptive feeding at 25±2°C and a humidity of 50±5%. The tranquilizing and sleep-aiding effects of the traditional Chinese medicine incense of examples 1-3 and comparative examples 1-5 were detected.

[0043] 1. The sleep incidence of the mice in the test was analyzed within 30 min by using sodium pentobarbital to induce the mice, wherein the sleep incidence = the number of sleeping mice / the total number of mice x 100%. Sleep was taken as an index of the disappearance of the righting reflex. When the mice were placed in a dorsal recumbency position, they could immediately turn over to a prone position. If they could not turn over for more than 30-60s, it was considered that the righting reflex had disappeared, and the mice entered sleep.

[0044] Experimental Methods: Mice were randomly divided into 9 groups, namely a blank control group, Example 1-3 groups, and Comparative Example 1-5 groups, with 10 mice in each group. The Example 1-3 groups and Comparative Example 1-5 groups were exposed to the burning of the Chinese herbal incense of Example 1-3 and Comparative Example 1-5 for 30 minutes once a day for 1 week. The blank control group was not exposed to the incense. The results are shown in Table 1.

[0045] Table 1

[0046] Note: #Compared with blank control group, P<0.05.

[0047] As can be seen from Table 1, compared with the blank control group, the Chinese medicinal incense prepared in Examples 1-3 can significantly increase the incidence of sleep in mice (P<0.05), and the sleep-aiding effect of the control group is reduced, indicating that the Elsholtzia calyx extract, the Euphorbia milii extract, and the Thalictrum serrata extract of the present invention have synergistic effects, and the lack of any one of the raw materials leads to a decrease in the incidence of sleep in mice.

[0048] In addition, the Chinese medicinal incense of Examples 1-3 of the present invention can also prolong deep sleep time, reduce the number of awakenings at night, and have a more powerful sleep-inducing effect.

[0049] 2. Divide the interior of the open wooden box into a light box and a dark box, with the light box occupying 3 / 5 of the box and the dark box occupying 2 / 5. Use a partition in the middle with a square cut at the bottom. Paint the light box white and illuminate it with a single incandescent bulb, while paint the dark box black and place an unpowered red bulb above it. Draw a 9cm square on the bottom of the box.

[0050] Experimental Methods: Mice were randomly divided into 9 groups (10 mice each), including a blank control group, groups of Examples 1-3, and groups of Comparative Examples 1-5. The mice were placed in a dark box with no red light and illuminated by an incandescent lamp in a bright box to induce anxiety. The mice in groups of Examples 1-3 and Comparative Examples 1-5 were exposed to the traditional Chinese medicine incense of Examples 1-3 and Comparative Examples 1-5 for 30 minutes. The mice were then placed in the center of the bright box with their backs facing the partition. The blank group received no incense exposure. The mice were observed for the number of times they switched between the bright and dark boxes within 5 minutes. A greater number of switching back and forth indicated greater anxiety. The results are shown in Table 2.

[0051] Table 2

[0052] It can be seen from the above data that the Chinese medicinal incense of Examples 1-3 of the present invention has a certain calming effect on mice and can alleviate anxiety symptoms.

[0053] In addition, the Chinese medicinal incense of the present invention can effectively kill harmful bacteria and harmful viruses in the air and prevent colds.

[0054] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine incense composition, characterized in that The invention comprises the following raw materials in parts by weight: 10-15 parts of sandalwood, 5-10 parts of safflower, 10-15 parts of agarwood, 2-4 parts of perilla leaves, 10-15 parts of esculenta calyx extract, 10-12 parts of euphorbia milii extract, and 8-10 parts of thuja serrata extract.

2. A Chinese medicine incense composition as claimed in claim 1, characterized in that, The preparation method of the Elsholtzia calyx extract is as follows: The Elsholtzia calycifolia L. is crushed, placed in a supercritical CO2 extraction device for extraction, and concentrated under reduced pressure to obtain the Elsholtzia calycifolia L. extract.

3. A Chinese medicine incense composition as claimed in claim 2, characterized in that, The supercritical CO2 extraction is first performed at 35-45°C and 15-25 MPa for 30-40 min, and then at 50-60°C and 30-40 MPa for 15-25 min.

4. A Chinese medicine incense composition as claimed in claim 1, characterized in that, The preparation method of the orange-yellow hibiscus flower extract is as follows: The orange-yellow hazelnut flower is crushed, added into a buffer solution, extracted, and concentrated under reduced pressure to obtain the orange-yellow hazelnut flower extract.

5. A Chinese medicine incense composition as claimed in claim 4, characterized in that, The buffer solution is any one of a lactic acid buffer solution, a citric acid buffer solution, a phosphate buffer solution, and a malic acid buffer solution; the material-liquid ratio of the orange-yellow jasmine flower to the buffer solution is 1:10-20 g / mL; and the extraction is performed at 40-60° C. for 1-2 hours.

6. A Chinese medicine incense composition as claimed in claim 1, characterized in that, The preparation method of the winged thrush extract is as follows: The samarachnid herb was crushed, added into an ethanol solution, and extracted by microwave heating. The extract was filtered through an ultrafiltration membrane with a molecular weight cutoff of less than 3000 Da and concentrated under reduced pressure to obtain the samarachnid herb extract.

7. A Chinese medicine incense composition as claimed in claim 6, characterized in that, The concentration of the ethanol solution is 40-60% v / v; the solid-liquid ratio of the samarassus tiliaceus to the ethanol solution is 1:6-10 g / mL; and the microwave extraction is performed at 400-500W and 60-70°C for 40-60 minutes.

8. The method for preparing a Chinese medicine incense composition according to claim 1, wherein The specific steps include: Grind and sieve sandalwood, safflower, agarwood and perilla leaves, grind and sieve Elsholtzia calyx extract, Rubus aurantii extract and Thalictrum lucidum extract, add adhesive and mix evenly, add water and stir into a fragrant ball, fill into a fragrance making machine, press into shape through a mold, dry naturally in the shade, and store in a sealed container.

9. The method for preparing a Chinese medicine incense composition according to claim 8, wherein The grinding and screening is through an 80-120 mesh sieve.

10. The method for preparing a Chinese medicine incense composition according to claim 8, wherein The adhesive is elm bark powder, and the added amount is 8%-10% of the total amount of the traditional Chinese medicine.

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