Targeted prebiotic plant extraction dietary powder for conditioning hypertension and preparation method thereof

Abstract

The invention discloses targeted prebiotic plant extraction dietary powder for conditioning hypertension and a preparation method thereof. According to the present invention, the lactobacillus plantarum CECT5716, the bifidobacterium lactis BLa80 and other strains selected in the formula can regulate the renin-angiotensin system balance by inhibiting the activity of the angiotensin converting enzyme so as to reduce the vasosystolic pressure from the neuroendocrine level; hawthorn flavone and pueraria isoflavone directly act on blood vessels to expand peripheral arteries, improve coronary artery blood flow and enhance blood vessel elasticity; the gamma-aminobutyric acid serving as a neurotransmitter can relieve sympathetic nerve hyperexcitation and reduce blood pressure fluctuation caused by emotion or pressure. Meanwhile, prebiotics such as resistant dextrin provide nutrients for probiotics, promote generation of intestinal short-chain fatty acids, activate a vascular endothelium protection pathway through an intestinal-metabolic axis, form a triple antihypertensive network of strain regulation, plant intervention and flora synergy, and cover different pathological links of blood pressure rise.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of dietary powder, and particularly relates to a targeted prebiotic plant extract dietary powder for regulating hypertension and a preparation method thereof. BACKGROUND

[0002] The plant dietary powder is a kind of nutrition supplement food made of a plurality of natural plants as raw materials, is widely applied to the modern healthy diet field, is rich in dietary fiber, plant protein, vitamins, minerals and antioxidant components, and can provide comprehensive and balanced nutrition support for the human body. The plant dietary powder does not contain animal-derived ingredients, is suitable for vegetarians, people with lactose intolerance and people pursuing a low-carbon and environmentally-friendly lifestyle to eat. The plant dietary powder is usually made by using low-temperature grinding, drying and other technologies to maximize the retention of plant nutrients. The plant dietary powder can be directly brewed and drunk, or can be added to yogurt, porridge or baked food, is convenient and fast, and is an ideal nutrition supplement way in the modern fast-paced life.

[0003] However, in the prior art, most plant dietary powders can only be supplemented by a single plant component to assist in regulating and cannot cover multiple pathological links; products containing probiotics are often lack of embedding technology, and the probiotics are easily destroyed by gastric acid, resulting in poor intestinal colonization; some products contain chemical additives or immediate-release sugars, and long-term use may cause metabolic burden. SUMMARY

[0004] The application aims to solve the above problems, and provides a targeted prebiotic plant extract dietary powder for regulating hypertension and a preparation method thereof.

[0005] The technical scheme adopted by the application is as follows: a targeted prebiotic plant extract dietary powder for regulating hypertension, the dietary powder comprising:

[0006] 2 parts by weight of Lactobacillus plantarum CECT5716;

[0007] 2 parts by weight of Bifidobacterium lactis BLa80;

[0008] 1 part by weight of Lactobacillus paracasei LPB2763;

[0009] 3 parts by weight of hawthorn flavonoids;

[0010] 2 parts by weight of pueraria isoflavones;

[0011] 2 parts by weight of eucommia green acid;

[0012] 1 part by weight of apocynum leaf extract;

[0013] 1 part by weight of gamma-aminobutyric acid;

[0014] 1 part by weight of hydroxytyrosol;

[0015] Resistant dextrin: 5 parts by weight;

[0016] Galacto-oligosaccharide: 3 parts by weight;

[0017] Fructo-oligosaccharide: 2 parts by weight;

[0018] Vitamin C: 0.5 parts by weight;

[0019] Magnesium: 0.3 parts by weight;

[0020] Potassium: 0.2 parts by weight;

[0021] Malt dextrin: 3 parts by weight.

[0022] In a preferred embodiment, a method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension comprises the following steps:

[0023] S1: Dry the plant raw materials such as hawthorn flavonoids and pueraria isoflavones at low temperature to a water content of ≤5%, and finely pulverize them into 80-mesh fine powder for use;

[0024] S2: Rehydrate the freeze-dried powder of the bacterial strain with 37℃ sterile normal saline for 30 minutes, add a double-layer microcapsule material for embedding, and protect the activity;

[0025] S3: Put the prebiotics such as resistant dextrin and galacto-oligosaccharide into a three-dimensional mixer according to the proportion, and mix at low speed for 15 minutes to form a uniform matrix;

[0026] S4: Add the embedded probiotics and prebiotic matrix to a double-cone mixer at a ratio of 1:5, and mix at low speed for 10 minutes to disperse the microcapsules and prevent adhesion;

[0027] S5: Slowly add the fine powder of plant extracts, and spray ethanol solution of γ-aminobutyric acid, etc., and mix at high speed for 20 minutes to fully contact and adsorb;

[0028] S6: Grind vitamin C, magnesium, potassium, and part of malt dextrin into a master batch, add it to the mixer and mix for another 15 minutes to ensure uniform distribution;

[0029] S7: Vacuum dry the material for 2 hours to a water content of ≤3%, and pass it through a granulator to improve flowability;

[0030] S8: Automatic packaging machine according to 4g / bag, aluminum plastic bag sealing; draw inspection of viable count, moisture, etc., and qualified for storage.

[0031] In a preferred embodiment, in step S1, the hawthorn flavones, pueraria isoflavones, eucommia green acid, and robor leaf extract are placed in a hot air circulating drying oven, the temperature is set to 40°C, and the drying is continued until the water content of the raw materials is ≤5%, to ensure that the materials do not stick together during the subsequent crushing process; after drying, the ultra-micro grinding equipment is used for grinding treatment, the equipment speed is set to 3000 rpm, and the grinding time is controlled to 15 minutes, and finally the fine powder with a particle size of 80 mesh is obtained. This particle size can maximize the contact area when the plant extract is mixed with other ingredients, and improve the mixing uniformity.

[0032] In a preferred embodiment, in step S2, the Lactobacillus plantarum CECT5716, Bifidobacterium lactis BLa80, and Lactobacillus paracasei LPB2763 freeze-dried powder are weighed according to the formula ratio, then 37°C sterile normal saline is added, and the strain is fully rehydrated and the metabolic activity is recovered in a constant temperature shaker at a speed of 100 rpm for 30 minutes; after activation, the bacterial solution is mixed with the double-layer microcapsule embedding material, the outer embedding material is a 2% sodium alginate solution, and the inner layer is a 1% chitosan solution. The embedding treatment is carried out by a spray drying equipment, the inlet air temperature is controlled to 100°C, and the outlet air temperature is controlled to 60°C, and finally the microcapsule particles with a particle size of 100-200 μm are formed. This process can increase the survival rate of probiotics in the stomach acid environment to more than 85%.

[0033] In a preferred embodiment, in step S3, the resistant dextrin, galactooligosaccharide, and fructooligosaccharide in the formula are weighed according to the proportion, and then are put into a three-dimensional motion mixer, the total capacity of the mixer is 50 L, the rotating speed is set to 20 rpm, and the mixing time is 15 minutes. During the mixing process, the three-dimensional motion mixer moves up and down, left and right, and forward and backward to fully interweave and disperse the three prebiotics. The sampling detection shows that the mixing uniformity RSD is ≤3%, which ensures the formation of a uniform prebiotic matrix and provides a stable nutrient environment for the subsequent probiotic colonization.

[0034] In a preferred embodiment, in step S4, the embedded probiotic microcapsules and the premixed prebiotic matrix are added into a double-cone mixer at a ratio of 1:5, the rotating speed of the mixer is set to 10 rpm, and the mixing time is 10 minutes. Low-speed mixing is adopted in this stage to avoid the rupture of the microcapsules caused by high-speed motion, and the porous structure of the prebiotic matrix is used to adsorb the water on the surface of the microcapsules to reduce the adhesion between the microcapsules. After mixing, random sampling observation shows that the microcapsules are uniformly distributed in the prebiotic matrix without obvious agglomeration.

[0035] In a preferred embodiment, in the step S5, the double-cone mixer is started, and the ultra-finely pulverized plant extract powder is added into the mixer at a uniform speed through a screw feeder, and the feeding speed is controlled at 2 kg / min to ensure uniform dispersion of the powder; at the same time, the 5% ethanol solution of gamma-aminobutyric acid and hydroxytyrosol is sprayed into the mixer through an atomizing nozzle, the pressure of the atomizing nozzle is set at 0.3 MPa, and the spraying time is synchronized with the plant extract feeding time; after the addition is completed, the mixing is continued for 20 minutes to enable the plant active ingredients to fully contact and adsorb the probiotic microcapsules and prebiotic substrate, and finally the uniformity RSD of the mixture is ≤5%.

[0036] In a preferred embodiment, in the step S6, the vitamin C, magnesium and potassium are added into a ball mill according to the formula proportion together with the malt dextrin, the grinding time is set at 20 minutes, and after grinding, the particle size of the material is ≤60 meshes to form a trace element master batch; the master batch is added into the double-cone mixer, the rotation speed is maintained at 25 revolutions / min, and the mixing is continued for 15 minutes to enable the vitamins, minerals and other trace elements to be uniformly distributed in the material by the carrier effect of the malt dextrin, so as to avoid local high concentration to affect the uniformity of the product; after the mixing is completed, the sample is detected, and the uniformity RSD of the trace element distribution is ≤2%.

[0037] In a preferred embodiment, in the step S7, the mixed material is transferred into a double-cone vacuum dryer, the vacuum degree is set at -0.08 MPa, the temperature is set at 35°C, and the drying time is set at 2 hours; during the drying process, the moisture content of the material is detected every 30 minutes, and finally the moisture content is controlled at ≤3% to prevent moisture absorption and caking; after the drying is completed, a swing granulator is used for granulation treatment, the granulator is equipped with a stainless steel screen with a pore size of 1.5 mm, the material is sieved by mechanical swinging to remove large particle agglomerates, and after the granulation, the flowability of the material is significantly improved, and the bulk density is controlled at 0.5-0.6 g / cm 3 .

[0038] In a preferred embodiment, in the step S8, an automatic powder packaging machine is used for sub-packaging, the packaging machine is set to have a single bag weight of 4 g, and the real-time calibration is performed through an electronic weighing module, and the sub-packaging error is controlled within ±0.1 g; the packaging material is selected to be an aluminum-plastic composite bag with a thickness of 0.08 mm, and the sealing temperature is set at 180°C to ensure the sealing effect; 10 bags are randomly taken from each batch of products for quality detection: the viable cell count detection is performed by the plate count method, and the viable cell count of each bag is required to be ≥120 billion CFU; the moisture content is detected by using a rapid moisture meter, and the moisture content is required to be ≤3%; the weight difference detection is performed according to the provisions of “Chinese Pharmacopoeia” General 0108, and after the qualification, the production date, batch number and label are printed and stored in the warehouse.

[0039] In summary, due to the adoption of the above technical scheme, the present application has the following beneficial effects:

[0040] 1. In this invention, the strains selected in the formula, such as Lactobacillus plantarum CECT5716 and Bifidobacterium lactis BLa80, inhibit the activity of angiotensin-converting enzyme and regulate the balance of the renin-angiotensin system, thereby reducing vasoconstriction pressure at the neuroendocrine level. Hawthorn flavonoids and kudzu root isoflavones act directly on blood vessels, dilating peripheral arteries, improving coronary blood flow, and enhancing vascular elasticity. Gamma-aminobutyric acid, as a neurotransmitter, can alleviate sympathetic nervous system overexcitation and reduce blood pressure fluctuations caused by emotion or stress. Simultaneously, prebiotics such as resistant dextrin provide nutrients for probiotics, promote the production of short-chain fatty acids in the intestine, and activate endothelial protective pathways through the gut-metabolism axis, forming a triple blood pressure-lowering network of "strain regulation + plant intervention + microbial synergy" to address the different pathological aspects of elevated blood pressure.

[0041] 2. The double-layer microencapsulation technology used in the preparation process of this invention ensures that probiotics remain active in the acidic environment of the stomach and directly colonize the intestines. The ultrafine grinding and uniform mixing process fully integrates the plant active ingredients and prebiotics. The 3-second instant dissolution feature is suitable for various scenarios such as exercise and office work, improving user compliance. In addition, the formula strictly adheres to special dietary standards and does not contain pharmaceutical ingredients, chemical additives, or fast-release sugars. It is combined with trace ingredients such as vitamin C, magnesium, and potassium to assist in antioxidant and balance sodium metabolism. This not only avoids the side effects that may be caused by traditional antihypertensive drugs, but also provides a more gentle and sustainable management solution for people with hypertension through daily dietary supplementation, helping to maintain long-term blood pressure stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 It is a schematic diagram of the process principle of the present invention. DETAILED DESCRIPTION

[0043] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0044] Example:

[0045] Reference Figure 1 ,

[0046] A targeted prebiotic plant extract dietary powder for regulating hypertension, the dietary powder comprising:

[0047] Lactobacillus plantarum CECT5716 (strain certified by the Spanish Ministry of Health): 2 parts by weight;

[0048] Bifidobacterium lactis BLa80 (clinically verified strain from Yangming University, Taiwan, China): 2 parts by weight;

[0049] Lactobacillus paracasei LPB2763 (new antihypertensive strain): 1 part by weight;

[0050] Hawthorn flavonoids (dilate coronary artery to improve blood flow): 3 parts by weight;

[0051] Pueraria isoflavones (regulate vascular elasticity): 2 parts by weight;

[0052] Eucommia ulmoides chlorogenic acid (inhibit angiotensin converting enzyme): 2 parts by weight;

[0053] Shouwu leaf extract (traditional antihypertensive herbal ingredients): 1 part by weight;

[0054] Gamma-aminobutyric acid (GABA, regulate neuroendocrine balance): 1 part by weight;

[0055] Hydroxytyrosol (repair vascular endothelial function): 1 part by weight;

[0056] Resistant dextrin (SCFAs precursor promotes short-chain fatty acid production): 5 parts by weight;

[0057] Galactooligosaccharides (GOS, target proliferative probiotics): 3 parts by weight;

[0058] Fructooligosaccharides (FOS, synergistic prebiotic effect): 2 parts by weight;

[0059] Vitamin C (antioxidant protection of blood vessels): 0.5 parts by weight;

[0060] Magnesium (assist vasodilation): 0.3 parts by weight;

[0061] Potassium (balance sodium metabolism): 0.2 parts by weight;

[0062] Maltodextrin (carrier and instant excipient): 3 parts by weight.

[0063] A preparation method of a targeted prebiotic plant extract dietary powder for regulating hypertension, comprising the following steps:

[0064] S1: Dry the plant raw materials such as hawthorn flavonoids and pueraria isoflavones at low temperature to a water content of ≤5%, and ultra-micro grind them into 80-mesh fine powder for standby.

[0065] S2: Take the strain freeze-dried powder, rehydrate it with 37℃ sterile normal saline for 30 minutes, add a double-layer microcapsule material for embedding (particle size 100-200μm), and protect the activity.

[0066] S3: Put the prebiotics such as resistant dextrin and galactooligosaccharides into a three-dimensional mixer according to the proportion, mix at low speed for 15 minutes, and form a uniform matrix.

[0067] S4: Add the probiotic-embedded and prebiotic matrix in a ratio of 1:5 into the double-cone mixer and mix at low speed for 10 minutes to disperse the microcapsules and prevent adhesion.

[0068] S5: Slowly add the fine powder of plant extracts while spraying the solution of gamma-aminobutyric acid in ethanol, and mix at high speed for 20 minutes to ensure full contact and adsorption.

[0069] S6: Grind the vitamin C, magnesium, potassium, and part of the malt dextrin into a master batch, add it to the mixer, and mix for another 15 minutes to ensure uniform distribution.

[0070] S7: Vacuum dry the material (35°C, -0.08 MPa) for 2 hours to a moisture content of ≤3%, and then pass it through a granulator (1.5 mm screen) to improve flowability.

[0071] S8: Use an automatic packaging machine to pack 4g per bag (error ±0.1g), seal in aluminum plastic bags, and perform random sampling for viable cell count (≥12 billion CFU per bag) and moisture content, and store in the warehouse if qualified.

[0072] In step S1, the plant raw materials such as hawthorn flavonoids, pueraria isoflavones, eucommia green acid, and robella leaf extract are placed in a hot air circulation drying oven, set to a temperature of 40°C, and dried continuously until the moisture content of the raw materials is ≤5%, ensuring that the materials do not stick together during subsequent grinding. After drying, the ultrafine grinding equipment is used for grinding, with the equipment speed set to 3000 revolutions per minute and the grinding time controlled to 15 minutes. The final fine powder has a particle size of 80 mesh, which can maximize the contact area between the plant extracts and other ingredients, improving the uniformity of mixing.

[0073] In step S2, take the freeze-dried powders of Lactobacillus plantarum CECT5716, Bifidobacterium lactis BLa80, and Lactobacillus paracasei LPB2763, weigh them according to the formula, and then add 37°C sterile physiological saline (the amount of physiological saline is 2 times the total weight of the strains). Shake in a constant-temperature shaker at 100 revolutions per minute for 30 minutes to fully rehydrate the strains and restore their metabolic activity. After activation, mix the bacterial solution with the double-layer microcapsule embedding material, with 2% sodium alginate solution as the outer embedding material and 1% chitosan solution as the inner embedding material. Use a spray drying device for embedding treatment, with the inlet temperature controlled at 100°C and the outlet temperature at 60°C. Finally, form microcapsule particles with a particle size of 100-200μm. This process can increase the survival rate of probiotics in the stomach acid environment to more than 85%.

[0074] In step S3, the resistant dextrin, galactooligosaccharide, and fructooligosaccharide in the formula are weighed in proportion, and then are put into a three-dimensional motion mixer. The total capacity of the mixer is 50 L, the rotating speed is set to 20 revolutions per minute, and the mixing time is 15 minutes. During the mixing process, the three-dimensional motion mixer performs complex movements of up and down, left and right, and forward and backward, so that the three prebiotics are fully interwoven and dispersed. After sampling detection, the uniformity RSD (relative standard deviation) is less than or equal to 3%, which ensures the formation of a uniform prebiotic matrix and provides a stable nutrient environment for subsequent probiotic colonization.

[0075] In step S4, the embedded probiotic microcapsules and the premixed prebiotic matrix are added to a double-cone mixer (capacity 50 L) at a ratio of 1:5. The rotating speed of the mixer is set to 10 revolutions per minute, and the mixing time is 10 minutes. Low-speed mixing is adopted in this stage to avoid microcapsule rupture caused by high-speed movement, and the porous structure of the prebiotic matrix is used to adsorb the moisture on the surface of the microcapsules, reducing the adhesion between the microcapsules. After mixing is completed, random sampling observation shows that the microcapsules are uniformly distributed in the prebiotic matrix without obvious agglomeration.

[0076] In step S5, the double-cone mixer is started (the rotating speed is kept at 25 revolutions per minute), and the ultra-finely ground plant extract powder is uniformly added to the mixer through a screw feeder at a speed of 2 kg per minute, ensuring uniform dispersion of the powder. At the same time, a 5% ethanol solution of gamma-aminobutyric acid and hydroxytyrosol is sprayed into the mixer through an atomizing nozzle, with the pressure of the atomizing nozzle set to 0.3 MPa. The spraying time is synchronized with the feeding time of the plant extract (about 5 minutes). After addition is completed, mixing is continued for 20 minutes to ensure that the active ingredients of the plant are in full contact with and adsorbed by the probiotic microcapsules and the prebiotic matrix. The final mixing uniformity RSD is less than or equal to 5%.

[0077] In step S6, vitamin C, magnesium, and potassium are added to a ball mill together with malt dextrin (30% of the total amount of malt dextrin) at the formula ratio. The grinding time is set to 20 minutes, and the particle size of the ground material is less than or equal to 60 mesh, forming a trace element master batch. The master batch is added to the double-cone mixer, and the rotating speed is kept at 25 revolutions per minute. Mixing is continued for 15 minutes to ensure that the vitamins and minerals are uniformly distributed in the material by the carrier effect of the malt dextrin, avoiding excessive local concentration that affects product uniformity. After mixing is completed, sampling detection shows that the uniformity RSD of the distribution of trace elements is less than or equal to 2%.

[0078] In step S7, the mixed material is transferred to a double-cone vacuum dryer, a vacuum degree of -0.08 MPa, a temperature of 35 DEG C, and a drying time of 2 hours are set. During the drying process, the moisture content of the material is detected every 30 minutes, and the final moisture content is controlled to be ≤3% to prevent moisture absorption and caking. After drying, a swing granulator is used for granulation treatment, the granulator is equipped with a stainless steel screen with a pore size of 1.5 mm, and the material is sieved by mechanical swinging to remove large particle agglomerates. After granulation, the flowability of the material is significantly improved, and the bulk density is controlled to be 0.5-0.6 g / cm 3 .

[0079] In step S8, an automatic powder packaging machine is used for packaging, the packaging machine is set to a single bag weight of 4 g, and is calibrated in real time by an electronic weighing module, and the packaging error is controlled to be within ±0.1 g. The packaging material is selected to be an aluminum-plastic composite bag with a thickness of 0.08 mm (oxygen barrier rate ≤0.5 cm 3 / m 2 ·24h), and the sealing temperature is set to 180 DEG C to ensure the sealing effect. Ten bags of each batch of product are randomly selected for quality detection: plate counting method is used for viable cell count detection, and the viable cell count of each bag is required to be ≥120 billion CFU; a rapid moisture meter is used for moisture detection, and the moisture content is required to be ≤3%; and the weight difference detection is performed according to the provisions of “Chinese Pharmacopoeia” general rule 0108, and the production date, batch number and label are printed and pasted into the warehouse after passing the test.

[0080] From the above, it can be seen that:

[0081] In the present application, the strains such as Lactobacillus plantarum CECT5716 and Bifidobacterium lactis BLa80 selected in the formula can reduce the vasoconstriction pressure from the neuroendocrine level by inhibiting the activity of angiotensin converting enzyme and regulating the balance of the renin-angiotensin system; the hawthorn flavones and pueraria isoflavones directly act on blood vessels, dilate peripheral arteries, improve coronary artery blood flow, and enhance vascular elasticity; gamma-aminobutyric acid as a neurotransmitter can relieve excessive excitement of the sympathetic nervous system and reduce blood pressure fluctuations caused by emotions or stress. At the same time, prebiotics such as resistant dextrin provide nutrients for probiotics, promote the generation of intestinal short-chain fatty acids, activate the vascular endothelial protection pathway through the gut-metabolism axis, and form a triple antihypertensive network of “strain regulation + plant intervention + flora synergy”, covering different pathological links of elevated blood pressure.

[0082] In the present application, the double-layer micro-capsule embedding technology used in the preparation process ensures that the probiotics remain active in the stomach acid environment and reach the intestinal flora; the ultra-fine grinding and uniform mixing process enables the plant active ingredients and prebiotics to fully integrate, the 3-second instant dissolving feature is suitable for various scenarios such as sports and office, and improves user compliance. In addition, the formula strictly follows the special dietary standards, does not contain drug ingredients, chemical additives and instant sugar, and is supplemented with trace ingredients such as vitamin C, magnesium and potassium to assist in antioxidant and sodium metabolism balance, which not only avoids the side effects that may be caused by traditional antihypertensive drugs, but also provides a more gentle and sustainable management solution for hypertensive people through daily dietary supplementation, which helps to maintain stable blood pressure for a long time.

[0083] It should be noted that, in this document, the terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the term "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such process, method, article or equipment. Without more limitations, the element defined by the statement "comprising a" does not exclude the presence of other identical elements in the process, method, article or equipment including the element.

[0084] The above examples are only used to illustrate the technical solutions of the present application, but not to limit it; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that they can still modify the technical solutions recorded in the foregoing examples, or make equivalent replacement for part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A targeted prebiotic plant extract dietary powder for regulating hypertension, characterized by: The dietary powder comprises: Lactobacillus plantarum CECT5716: 2 parts by weight; Bifidobacterium lactis BLa80: 2 parts by weight; Lactobacillus paracasei LPB2763: 1 part by weight; Hawthorn flavonoids: 3 parts by weight; Pueraria isoflavones: 2 parts by weight; Eucommia ulmoides chlorogenic acid: 2 parts by weight; Apocynum venetum leaf extract: 1 part by weight; γ-aminobutyric acid: 1 part by weight; Hydroxytyrosol: 1 part by weight; Resistant dextrin: 5 parts by weight; Galacto-oligosaccharide: 3 parts by weight; Fructooligosaccharides: 2 parts by weight; Vitamin C: 0.5 parts by weight; Magnesium: 0.3 parts by weight; Potassium: 0.2 parts by weight; Maltodextrin: 3 parts by weight.

2. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: The preparation method comprises the following steps: S1: Drying the plant materials such as hawthorn flavonoids and kudzu root isoflavones at low temperature to a moisture content of ≤5%, and ultrafine grinding into 80 mesh fine powder for later use; S2: Take the lyophilized powder of the strain and rehydrate it with sterile saline at 37°C for 30 minutes, then add double-layer microcapsule material to embed it to protect its activity; S3: Add resistant dextrin and galacto-oligosaccharide prebiotics in proportion to a three-dimensional mixer and mix at low speed for 15 minutes to form a uniform matrix; S4: Add the embedded probiotics and prebiotic matrix into a double cone mixer at a ratio of 1:5 and mix at low speed for 10 minutes to disperse the microcapsules and prevent adhesion; S5: Slowly add the fine powder of plant extract and spray the ethanol solution of γ-aminobutyric acid at the same time, mix at high speed for 20 minutes to ensure sufficient contact and adsorption; S6: Grind vitamin C, magnesium, potassium and part of maltodextrin into a masterbatch, add it to the mixer and mix for another 15 minutes to ensure uniform distribution; S7: The material is vacuum dried for 2 hours until the moisture content is ≤3%, and then granulated by a granulator to improve fluidity; S8: The automatic packaging machine packs the products into 4g / bag and seals them in aluminum-plastic bags; the number of viable bacteria, moisture content, etc. are randomly inspected and those that meet the requirements are put into storage.

3. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In the step S1, plant raw materials such as hawthorn flavonoids, kudzu isoflavones, eucommia ulmoides chlorogenic acid, and apocynum venetum leaf extract are placed in a hot air circulation drying oven, the temperature is set to 40°C, and the raw materials are dried continuously until the moisture content is ≤5%, ensuring that the materials are not easy to stick together during the subsequent crushing process; after drying, ultrafine grinding equipment is used for grinding, the equipment speed is set to 3000 rpm, and the crushing time is controlled at 15 minutes, and finally a fine powder with a particle size of 80 mesh is obtained. This particle size can ensure that the contact area when the plant extract is mixed with other ingredients is maximized, thereby improving the mixing uniformity.

4. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In step S2, freeze-dried powders of Lactobacillus plantarum CECT5716, Bifidobacterium lactis BLa80, and Lactobacillus paracasei LPB2763 are weighed according to the formula ratio, added with 37° C. sterile saline, and shaken in a constant temperature shaker at 100 rpm for 30 minutes to fully rehydrate the strains and restore metabolic activity; After activation is completed, the bacterial liquid is mixed with a double-layer microcapsule embedding material. The outer layer embedding material is a 2% sodium alginate solution, and the inner layer is a 1% chitosan solution. The embedding treatment is carried out through a spray drying equipment, and the inlet air temperature is controlled at 100°C and the outlet air temperature is controlled at 60°C. Finally, microcapsule particles with a particle size of 100-200μm are formed. This process can increase the survival rate of probiotics in the gastric acid environment to more than 85%.

5. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, wherein: In step S3, the resistant dextrin, galacto-oligosaccharide, and fructo-oligosaccharide in the formula are weighed in proportion and then put into a three-dimensional motion mixer with a total capacity of 50 L, a set speed of 20 rpm, and a mixing time of 15 minutes. During the mixing process, the three-dimensional motion mixer fully interweaves and disperses the three prebiotics through a compound motion of up and down, left and right, and front and back. After sampling and testing, the mixing uniformity RSD is ≤3%, ensuring the formation of a uniform prebiotic matrix and providing a stable nutritional environment for subsequent probiotic colonization.

6. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In step S4, the embedded probiotic microcapsules and the premixed prebiotic matrix are added to a double-cone mixer at a ratio of 1:5, and the mixer speed is set to 10 rpm for 10 minutes. Low-speed mixing is used in this stage to avoid microcapsule rupture caused by high-speed movement. At the same time, the porous structure of the prebiotic matrix is ​​used to absorb moisture on the surface of the microcapsules and reduce adhesion between the microcapsules. After the mixing is completed, random sampling is performed for observation, and the microcapsules are evenly distributed in the prebiotic matrix without obvious agglomeration.

7. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In step S5, the double-cone mixer is started, and the ultrafinely crushed plant extract powder is added to the mixer at a uniform speed through a spiral feeder, and the feeding speed is controlled to 2 kg / min to ensure that the fine powder is evenly dispersed; at the same time, a 5% ethanol solution of γ-aminobutyric acid and hydroxytyrosol is sprayed into the mixer through an atomizing nozzle, and the atomizing nozzle pressure is set to 0.3 MPa, and the spraying time is synchronized with the plant extract feeding time; after the addition is completed, the mixing is continued for 20 minutes to allow the plant active ingredients to fully contact and adsorb with the probiotic microcapsules and prebiotic matrix, and the final mixing uniformity RSD is ≤5%.

8. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In step S6, vitamin C, magnesium, and potassium are put into a ball mill together with maltodextrin according to the formula ratio, and the grinding time is set to 20 minutes. The particle size of the material after grinding is ≤60 mesh, thereby forming a trace component masterbatch; the masterbatch is added to a double cone mixer, the speed is maintained at 25 rpm, and mixing is carried out for 15 minutes. The carrier effect of maltodextrin is used to evenly distribute trace components such as vitamins and minerals in the material to avoid local excessive concentration affecting product uniformity. After mixing, sampling is carried out for testing, and the trace component distribution uniformity RSD is ≤2%.

9. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, wherein: In step S7, the mixed material is transferred to a double-cone vacuum dryer, the vacuum degree is set to -0.08 MPa, the temperature is set to 35°C, and the drying time is 2 hours; during the drying process, the moisture content of the material is sampled and tested every 30 minutes, and the final moisture content is controlled at ≤3% to prevent moisture absorption and agglomeration; after the drying is completed, a swing granulator is used for granulation. The granulator is equipped with a stainless steel screen with an aperture of 1.5 mm. The material is sieved by mechanical swing to remove large particle agglomerates. The fluidity of the material is significantly improved after granulation, and the bulk density is controlled at 0.5-0.6 g / cm 3 between.

10. The method for preparing a targeted prebiotic plant extract dietary powder for regulating hypertension according to claim 1, characterized in that: In step S8, an automatic powder packaging machine is used for packaging. The packaging machine is set to a single bag weight of 4g, and the packaging error is controlled within ±0.1g through real-time calibration of the electronic weighing module. The packaging material is an aluminum-plastic composite bag with a thickness of 0.08mm, and the sealing temperature is set to 180°C to ensure the sealing effect. Ten bags are randomly selected from each batch of products for quality inspection: the viable bacteria count is tested using the plate count method, and the viable bacteria count per bag is required to be ≥12 billion CFU; the moisture content is tested using a rapid moisture meter, and the moisture content is required to be ≤3%.

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