Composition for relieving itching and relieving body and mixing preparation device thereof

Abstract

The invention discloses a body itching relieving and soothing composition and a mixing preparation device thereof, and particularly relates to the technical field of skin care products, the body itching relieving and soothing composition comprises 0.1%-0.5% of hydroxy acid menthyl ester, 0.5%-1.5% of paeonol, 2%-5% of a purslane extract, 1%-3% of panax notoginseng saponins, 0.05%-0.2% of ceramide NP, 0.1%-1% of a compound of zingiberol and oat alkaloid, and the balance of water. And a pharmaceutically or cosmetically acceptable matrix. Efficient itching relieving and high safety are achieved through a multi-target-point synergistic natural composition, the ingredient activity and the product stability are guaranteed through a matched integrated preparation process, the instant relieving and long-acting repairing effects are achieved, and the application scene is wide.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of skin care products, more particularly, the present application relates to a body anti-itching soothing composition and a mixing preparation device thereof. BACKGROUND

[0002] Skin itching is caused by mosquito bites, allergies, dryness and eczema, and has complex causes and is prone to recurrence;

[0003] Existing anti-itching products have obvious limitations: chemical synthesis products are prone to side effects or drug resistance, hormone products have significant effects, but long-term use can cause skin problems, and natural ingredient products often rely on a single ingredient, have short-term anti-itching effects and are prone to recurrence, and the active ingredients are often degraded due to lack of protection measures during preparation.

[0004] According to the search, the Chinese invention patent with the publication number CN115607493A discloses an anti-itching soothing composition and a preparation method thereof, which has the advantage of improving the anti-itching soothing effect.

[0005] However, in actual use, although the anti-itching soothing effect can be achieved to a certain extent, the mechanism is relatively single, only focusing on inflammation inhibition, and lacking comprehensive consideration of nerve signal blocking and skin barrier repair, and when facing complex and diverse causes of itching, such as dry skin and nerve dysfunction, the effect is poor, in addition, from the preparation process, effective measures are not taken to avoid oxidation and degradation of ingredients during extraction and mixing, resulting in a decrease in the content of effective ingredients during storage and use, affecting the durability and stability of the product;

[0006] In addition, some existing anti-itching products only target acute itching scenarios, such as short-term anti-itching after mosquito bites, and cannot meet the long-term care needs of chronic itching patients, and cannot achieve long-term and effective auxiliary treatment for chronic itching symptoms such as eczema and atopic dermatitis, and in the use process, the skin may be further burdened due to the presence of irritating ingredients, causing skin allergies and other adverse reactions.

[0007] In view of the above situation, the present application provides a body anti-itching soothing composition and a mixing preparation device thereof. SUMMARY

[0008] In order to overcome the above-mentioned defects of the prior art, the present application provides a body anti-itching soothing composition and a mixing preparation device thereof to solve the problems raised in the background art.

[0009] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a body anti-itching soothing composition, comprising the following active ingredients in percentage by weight:

[0010] hydroxy acid menthyl ester 0.1%-0.5%, paeonol 0.5%-1.5%, purslane extract 2%-5%, total ginseng saponins 1%-3%, ceramide NP 0.05%-0.2%, gingerol and avenin alkaloid complex 0.1%-1%, and a pharmaceutically or cosmetically acceptable base.

[0011] Preferably, the preferred proportion of the active ingredients is: hydroxy acid menthyl ester 0.3%, paeonol 1.0%, purslane extract 3.5%, total ginseng saponins 2.0%, ceramide NP 0.1%, gingerol and avenin alkaloid complex 0.5%.

[0012] Preferably, the base is a water-based gel base or an O / W emulsion base.

[0013] Preferably, it specifically comprises the following steps:

[0014] S1, under the protection of inert gas environment, heat the base to 35-45°C and stir to homogenize;

[0015] S2, keep the inert gas environment and stirring, and cool the mixed system to 4-10°C;

[0016] S3, under the low temperature condition of 4-10°C, sequentially add purslane extract, total ginseng saponins, ceramide NP, and gingerol and avenin alkaloid complex, and perform high shear emulsification;

[0017] S4, under the condition of continuous stirring and low temperature, add hydroxy acid menthyl ester and paeonol, and stir uniformly;

[0018] S5, while stirring, perform dynamic vacuum degassing on the mixed system until the bubbles are completely eliminated, to obtain the body itching-relieving soothing composition.

[0019] The application also provides a mixing preparation device for preparing the above-mentioned body itching-relieving soothing composition, comprising:

[0020] a main mixing kettle provided with a feeding port with a sealing cover at the top and a discharging valve at the bottom;

[0021] an inert gas supply system connected with the gas inlet at the upper part of the main mixing kettle through a first pipeline, wherein a first control valve is arranged on the first pipeline;

[0022] a temperature control system comprising a jacket wrapped around the outer wall of the main mixing kettle and a semiconductor refrigeration unit providing cooling liquid for the jacket;

[0023] a driving motor fixedly installed at the center of the top of the main mixing kettle;

[0024] The high shear emulsification mechanism comprises a transmission shaft driven by a driving motor and an emulsification head fixedly installed at the end of the transmission shaft, and the emulsification head is located in the interior of the main mixing kettle.

[0025] The vacuum degassing system is connected with the air outlet at the top of the main mixing kettle through a second pipeline, and a vacuum pump and a second control valve are sequentially arranged on the second pipeline.

[0026] Preferably, the outlet of the discharging valve is directly connected to the inlet of the filling device through a third pipeline, thereby forming a closed discharging channel.

[0027] Preferably, a mechanical seal is arranged at the connection between the transmission shaft of the high shear emulsification mechanism and the top of the main mixing kettle, and the emulsification head is in a stator-rotor structure and is located in the central area at the bottom of the main mixing kettle.

[0028] Preferably, the mixing preparation device further comprises a control unit electrically connected with the driving motor, the semiconductor refrigeration unit, the vacuum pump, the first control valve and the second control valve, and used for controlling the start-stop, temperature, vacuum degree and time sequence of inert gas replacement of the mixing preparation process.

[0029] Preferably, a temperature sensor and a pressure sensor connected with the control unit are further arranged in the main mixing kettle.

[0030] Preferably, the jacket is a spiral flow guide plate type jacket, the outlet of the jacket is connected to the inlet of the jacket through a pump and a fourth pipeline, and the outlet of the jacket is returned to the semiconductor refrigeration unit through a fifth pipeline.

[0031] Technical effects and advantages of the present application:

[0032] 1、The composition of the present application activates the cold receptor and calms the nerve endings through the synergistic effect of hydroxy acid menthyl ester and paeonol, rapidly blocks the itch signal transduction, and the extract of spilanthes acmella and panax notoginseng inhibit the release of inflammatory factors from different inflammatory pathways, cut off the inflammatory inducement of itch, and the ceramide NP and gingerol-oat alkaloid complex supplement skin lipids and enhance the integrity of the stratum corneum, thereby reducing the recurrence of itch from the root, avoiding the effect limitation of single component, and the overall composition does not contain hormones and strong chemical antipruritic agents, thereby avoiding the risks of skin atrophy and drug resistance;

[0033] 2、The mixed preparation device of the application is protected by inert gas throughout the process, which prevents the destruction of easily oxidized components such as spilanthes extract by oxygen, and the volatilization of hydroxy acid menthol ester and the thermal sensitivity degradation of total notoginseng saponins are inhibited in a low-temperature environment of 4-10 DEG C, the high-shear emulsification and dynamic vacuum degassing are carried out synchronously, which not only ensures the uniform dispersion of liposoluble components such as ceramide NP in the water-based matrix, but also avoids the problem of uneven distribution of components caused by bubbles, the whole process from material addition to filling is closed, the biological activity of each active ingredient is maximally retained, and the stable antipruritic and anti-inflammatory effect of the product can be maintained during the storage period;

[0034] 3、The composition of the application relieves itching through cold sensation signal coverage, then prevents itching from aggravating by inhibiting inflammatory response, and long-term use reduces the itching susceptibility of sensitive skin by repairing skin barrier, so that it can cope with acute itching such as mosquito bites and dry skin, and is also suitable for the auxiliary care of chronic itching such as eczema and atopic dermatitis, and is more widely applicable to people and scenes. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 It is the overall process flowchart of the application.

[0036] Figure 2 It is the structure schematic diagram of the mixed preparation device of the application.

[0037] Figure 3 It is the connection structure schematic diagram of the driving motor and the high-shear emulsification mechanism of the application.

[0038] Figure 4 It is the connection structure schematic diagram of the fourth pipeline and the fifth pipeline and the semiconductor refrigeration unit of the application.

[0039] Figure 5 It is the internal structure schematic diagram of the main mixing kettle of the application.

[0040] Figure 6 It is the bottom structure schematic diagram of the main mixing kettle of the application.

[0041] The figure mark is: 1, main mixing kettle;11, feeding port;12, discharge valve;2, inert gas supply system;21, first pipeline;13, gas inlet;22, first control valve;3, temperature control system;31, jacket;32, semiconductor refrigeration unit;41, driving motor;4, high-shear emulsification mechanism;42, transmission shaft;43, emulsification head;5, vacuum degassing system;51, second pipeline;14, air outlet;52, vacuum pump;53, second control valve;61, third pipeline;44, mechanical seal;6, control unit;15, temperature sensor;16, pressure sensor;33, pump;34, fourth pipeline;35, fifth pipeline. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0043] Embodiment 1,

[0044] The embodiment of the present application provides a body itching-relieving and soothing composition, which contains, by weight percentage, 0.1% of menthyl hydroxyacetate, 0.5% of paeonol, 2% of spilanthes extract, 1% of total notoginseng saponins, 0.05% of ceramide NP, 0.1% of a compound of gingerol and avenanthramides, and the rest is a water-based gel base (supplemented with 0.5% of carbomer, 5% of glycerol and deionized water);

[0045] In the composition of this embodiment, menthyl hydroxyacetate and paeonol can quickly act on nerve endings to relieve itching, spilanthes extract and total notoginseng saponins can inhibit inflammatory factors from different pathways to reduce skin inflammation, and ceramide NP and the compound of gingerol and avenanthramides synergistically act to supplement skin lipids and enhance skin barrier function.

[0046] Embodiment 2,

[0047] The embodiment of the present application provides a body itching-relieving and soothing composition, which is composed of, by weight percentage, 0.3% of menthyl hydroxyacetate, 1.0% of paeonol, 3.5% of spilanthes extract, 2.0% of total notoginseng saponins, 0.1% of ceramide NP, 0.5% of a compound of gingerol and avenanthramides, and the rest is an O / W emulsion base (supplemented with 3% of stearic acid, 1.5% of glycerol monostearate, 8% of glycerol, 0.1% of nipagin ethyl and deionized water);

[0048] This embodiment is a composition with a preferred ratio, and the proportions of the components are scientifically optimized, and the synergistic effect is remarkable. Not only can it quickly relieve itching, but also its anti-inflammatory and skin barrier repair capabilities are more balanced, and it is suitable for various skin itching scenarios, and is mild and non-irritating when used.

[0049] Embodiment 3,

[0050] The embodiment of the present application provides a body itching-relieving and soothing composition, which contains, by weight percentage, 0.5% of menthyl hydroxyacetate, 1.5% of paeonol, 5% of spilanthes extract, 3% of total notoginseng saponins, 0.2% of ceramide NP, 1% of a compound of gingerol and avenanthramides, and the rest is a water-based gel base (supplemented with 0.3% of hyaluronic acid, 6% of propylene glycol and deionized water);

[0051] The composition of the embodiment has a relatively high content of active ingredients, and has a stronger relieving and improving effect on itching problems caused by severe skin barrier damage or strong inflammatory reaction, and can more quickly inhibit inflammation and promote skin barrier repair.

[0052] Embodiment A,

[0053] The embodiment of the present application also provides a mixing preparation device for preparing the above-mentioned body itching relieving and soothing composition, which comprises a main mixing kettle 1, a feeding port 11 with a sealing cover arranged at the top of the main mixing kettle 1, a discharging valve 12 arranged at the bottom of the main mixing kettle 1, an inert gas supply system 2 connected with an air inlet 13 arranged at the upper portion of the main mixing kettle 1 through a first pipeline 21, a first control valve 22 arranged on the first pipeline 21, a temperature control system 3 comprising a spiral flow guide plate type jacket 31 wrapped around the outer wall of the main mixing kettle 1 and a semiconductor refrigerating unit 32 for providing cooling liquid for the jacket 31, a cooling liquid outlet of the semiconductor refrigerating unit 32 connected to the inlet of the jacket 31 through a pump 33 and a fourth pipeline 34, and an outlet of the jacket 31 backflowing to the semiconductor refrigerating unit 32 through a fifth pipeline 35, a driving motor 41 fixedly installed at the center of the top of the main mixing kettle 1, a high-shear emulsification mechanism 4 comprising a transmission shaft 42 driven by the driving motor 41 and an emulsification head 43 fixedly installed at the end of the transmission shaft 42, a mechanical seal 44 arranged at the connection position of the transmission shaft 42 and the top of the main mixing kettle 1, the emulsification head 43 being in a stator-rotor structure and located at the bottom center area of the main mixing kettle 1, a vacuum degassing system 5 connected with a gas extraction port 14 arranged at the top of the main mixing kettle 1 through a second pipeline 51, a vacuum pump 52 and a second control valve 53 arranged on the second pipeline 51 in sequence, and an outlet of the discharging valve 12 directly connected to the inlet of a filling device through a third pipeline 61 to form a closed discharging channel;

[0054] The device can more uniformly control the temperature in the main mixing kettle 1 through the spiral flow guide plate type jacket 31, the emulsification head 43 in the stator-rotor structure is located at the bottom center area and can efficiently disperse and emulsify the materials, and the closed discharging channel can reduce the contact of the materials with air and ensure the product quality.

[0055] Embodiment B,

[0056] The embodiment of the present application also provides a mixing preparation device, which specifically comprises the control unit 6, the driving motor 41, the semiconductor refrigerating unit 32, the vacuum pump 52, the first control valve 22 and the second control valve 53 are electrically connected with the control unit 6, and the temperature sensor 15 and the pressure sensor 16 connected with the control unit 6 are further arranged in the main mixing kettle 1.

[0057] The control unit 6 can receive feedback information of the temperature sensor 15 and the pressure sensor 16, automatically adjust the operating state of each component, and realize automatic control of the mixed preparation process. For example, when the temperature exceeds the set range, the control unit 6 will automatically adjust the operating power of the semiconductor refrigeration unit 32 to ensure that the temperature is stable within the target range.

[0058] Embodiment C,

[0059] The embodiment of the present application also provides a mixed preparation device, which is different from the embodiment B in that the jacket 31 is a common annular jacket 31, and the remaining structure is the same as that of the embodiment B.

[0060] The common annular jacket 31 has a relatively simple structure and low manufacturing cost, and although it is slightly inferior to the spiral guide plate type jacket 31 in temperature control uniformity, it can still meet the basic temperature control requirements and is suitable for production scenarios that are more sensitive to production costs.

[0061] Embodiment a,

[0062] In this embodiment, the mixed preparation device of embodiment A is used to prepare the composition of embodiment 1, and the specific preparation process is as follows:

[0063] S1, open the feeding port 11 with a sealing cover at the top of the main mixing kettle 1, put the raw materials of the water-based gel matrix (0.5% carbomer, 5% glycerol, and deionized water to make up the balance) into the main mixing kettle 1, close the sealing cover, start the inert gas supply system 2, open the first control valve 22, and introduce nitrogen into the main mixing kettle 1 to make the pressure in the kettle reach 0.1 MPa. After maintaining for 3 min, close the first control valve 22, complete the first inert gas replacement, repeat this operation 2 times to ensure that the air in the kettle is fully discharged, start the semiconductor refrigeration unit 32 of the temperature control system 3, and at the same time, start the driving motor 41 to drive the transmission shaft 42 and the emulsifying head 43 of the high-shear emulsification mechanism 4 to stir at a low speed, the speed is 500 r / min, heat the matrix to 35℃ and stir for 10 min to make it uniform;

[0064] S2, keep the inert gas environment and stirring, and reduce the mixed system to 4℃ through the temperature control system 3;

[0065] S3, under the condition of low temperature of 4℃, add purslane extract 2%, total saponins of notoginseng 1%, ceramide NP 0.05%, and the compound of gingerol and oat alkaloids 0.1% from the feeding port 11 in sequence, increase the speed of the high-shear emulsification mechanism 4 to 3000 r / min, and emulsify for 15 min;

[0066] S4, keep stirring at a speed of 1000 r / min and under the condition of low temperature of 4℃, add hydroxy acid menthol 0.1% and paeonol 0.5%, and continue to stir for 10 min until uniform;

[0067] S5, turn on the vacuum degassing system 5, open the second control valve 53, start the vacuum pump 52, control the vacuum degree in the kettle at-0.08 MPa, and carry out dynamic vacuum degassing at a stirring speed of 500 r / min for 20 min until the bubbles are completely eliminated, then close the vacuum pump 52 and the second control valve 53, open the inert gas supply system 2 to restore the normal pressure in the kettle, open the bottom discharge valve 12, and transport the prepared composition to the filling equipment through the third pipeline 61 for filling to obtain the body itching relieving and soothing composition.

[0068] Example B,

[0069] This example uses the mixing preparation device of Example B to prepare the composition of Example 2, and the specific preparation process is as follows:

[0070] S1, the control unit 6 presets the parameters: inert gas replacement 3 times, each time nitrogen is introduced to 0.12 MPa, maintaining for 2 min, substrate heating temperature 40°C, target temperature 7°C, high shear emulsification speed 3500 r / min, emulsification time 20 min, post-stirring speed 1200 r / min, vacuum degassing vacuum degree-0.09 MPa, and degassing time 15 min;

[0071] S2, open the feeding port 11, and add the O / W emulsion substrate raw materials (stearic acid 3%, glycerol monostearate 1.5%, glycerol 8%, nipagin ethyl ester 0.1%, and deionized water to make up the balance), close the feeding port 11, and the control unit 6 automatically starts the inert gas supply system 2 to complete the replacement;

[0072] S3, the control unit 6 automatically starts the driving motor 41 (initial speed 600 r / min) and the temperature control system 3, heats the substrate to 40°C and stirs for 12 min until uniform, and then automatically cools to 7°C;

[0073] S4, manually add the extract of purslane 3.5%, total ginsenoside of panax notoginseng 2.0%, ceramide NP 0.1%, and the compound of gingerol and avenanthramides 0.5% from the feeding port 11 in turn, the control unit 6 automatically adjusts the high shear emulsification mechanism 4 to a speed of 3500 r / min, and emulsifies for 20 min;

[0074] S5, the control unit 6 automatically reduces the speed to 1200 r / min, manually adds hydroxy acid menthyl ester 0.3% and paeonol 1.0%, stirs for 12 min, and then the control unit 6 automatically starts the vacuum degassing system 5 to degas according to the preset parameters;

[0075] S6, after degassing, the control unit 6 automatically balances the pressure in the kettle, opens the discharge valve 12, and transports to the filling equipment through the sealed channel, and the whole process temperature sensor 15 and pressure sensor 16 real-time feedback data to ensure process stability.

[0076] Example C,

[0077] This example uses the mixing preparation device of Example C to prepare the composition of Example 3, and the specific preparation process is as follows:

[0078] S1, manually operate the inert gas supply system 2 to introduce argon into the main mixing kettle 1, replace 3 times, each time the pressure is 0.1 MPa, maintain for 3 min, and then put in the water-based gel matrix raw material (hyaluronic acid 0.3%, propylene glycol 6%, deionized water to make up to the balance);

[0079] S2, start the drive motor 41 (speed 550 r / min) and the jacket 31 temperature control of the semiconductor refrigeration unit 32, heat the matrix to 45℃, and stir for 15 min until uniform, then cool to 10℃;

[0080] S3, add purslane extract 5%, panax notoginseng total saponins 3%, ceramide NP 0.2%, and the compound of gingerol and avenanthramides 1% in sequence, and start high shear emulsification (speed 4000 r / min) for 25 min;

[0081] S4, reduce the speed to 1500 r / min, add hydroxy acid menthyl ester 0.5% and paeonol 1.5%, stir for 15 min, then start vacuum defoaming (vacuum degree -0.07 MPa) for 25 min;

[0082] S5, close the vacuum system, introduce argon to normal pressure, open the discharge valve 12 to complete filling, and the ordinary annular jacket 31 maintains the temperature in the range of 8-10℃ during the process.

[0083] The body itching relieving and soothing compositions prepared in the above Examples 1-3 are marked as S1, S2 and S3 respectively, and the comparative samples are marked as D1, D2, D3 and D4 respectively, wherein;

[0084] D1 is a commercially available 0.5% hydrocortisone hormone itching cream (positive control);

[0085] D2 is a composition containing only hydroxy acid menthyl ester 0.3% and paeonol 1.0%, a single itching component, and the matrix is the same as Example 2;

[0086] D3 is a composition containing only purslane extract 3.5% and panax notoginseng total saponins 2.0%, a single anti-inflammatory component, and the matrix is the same as Example 2;

[0087] D4 is a composition without the compound of gingerol and avenanthramides, and the formula is the same as Example 2, and the proportions of the remaining components remain unchanged.

[0088] The specific test steps are as follows:

[0089] 1. Itching relief test, 60 volunteers with itching symptoms (itching degree 3-4, 10 levels) were recruited and randomly divided into 6 groups, 10 people in each group, corresponding to each test sample. After cleaning the itching part, the corresponding sample was applied (1-2g, adjusted according to the area), and the itching degree was recorded at 5min, 15min, 30min and 60min after application by visual analog scale (VAS, 0 points for no itching, 10 points for extreme itching), and the itching relief rate was calculated (initial score-test score) / initial score x 100%;

[0090] 2. Anti-inflammatory effect test, 60 volunteers with local erythema due to mosquito bites or mild allergy were selected and randomly divided into 6 groups, 10 people in each group, corresponding to each test sample. The erythema part was applied with the corresponding sample (0.5g / plac), twice a day for 2 days, and the change of erythema diameter before and after 2 days of application was recorded, and the erythema regression rate was calculated (initial diameter-2 days later diameter) / initial diameter x 100%;

[0091] 3. Skin barrier repair test, 30 volunteers with slightly damaged skin barrier on the inner side of the forearm (transdermal water loss value slightly higher than normal) were recruited and randomly divided into 3 groups, 10 people in each group, corresponding to S2, D1 and D4. The damaged part was applied with the sample twice a day (0.5g / time) for 5 days, and the stratum corneum water content was detected before and after 5 days by skin moisture meter (the higher the value, the better the barrier repair).

[0092] After testing, the results are shown in the following table:

[0093]

[0094]

[0095] Table 1 is the itching relief test result

[0096]

[0097] Table 2 is the anti-inflammatory effect test result

[0098] Before application After 5 days of application S2 32.5±4.2 58.6±5.8 D1 31.8±4.0 45.2±5.0 D4 32.1±4.1 40.3±4.8

[0099] Table 3 is the skin barrier repair test result

[0100] From the data in the above table, it can be seen that:

[0101] Itching relief effect: S2 and S3 have itching relief rate close to D1 (hormone) at 60min, but there is no hormone-dependent risk, D2 and D3 single component group have significantly lower relief rate, and D4 has weaker effect than S2 due to lack of key compound, which verifies the necessity of multi-component synergy;

[0102] Anti-inflammatory effect: the erythema subsidence rate of S2 is 75.6%, close to D1 (78.2%) and significantly higher than other comparative samples, indicating that the anti-inflammatory effect is derived from multi-target synergistic effect;

[0103] Barrier repair: the stratum corneum water content of S2 after 5 days of application is much higher than that of D1 and D4, proving that its ability to repair the skin barrier is better, especially the gingerol-oat alkaloid complex can enhance the repair effect.

[0104] Conclusion:

[0105] The composition of the present application realizes the efficient synergistic effect of natural ingredients by compounding hydroxyl acid menthyl ester, paeonol, spilanthes acmella extract, panax notoginseng saponins, ceramide NP and gingerol-oat alkaloid complex, wherein, hydroxyl acid menthyl ester and paeonol quickly block the itching signal, spilanthes acmella extract and panax notoginseng saponins inhibit inflammatory reaction from different pathways, ceramide NP and gingerol-oat alkaloid complex synergistically repair the skin barrier, and the three form a closed loop antipruritic repair mechanism, solving the problems of large chemical component side effects and single natural ingredient effect in the prior art;

[0106] Meanwhile, the preparation mixing device matched with the present application realizes the integrated operation of inert gas protection, 4-10 DEG C precise temperature control, high shear emulsification and dynamic vacuum defoaming, maximally retains the stability of active ingredients, and solves the technical pain point of easy degradation of active ingredients in the traditional preparation process.

[0107] The above only describes the preferred embodiments of the present application and is not used to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A body antipruritic and soothing composition, characterized in that: Calculated by weight percentage, it includes the following active ingredients: Menthyl hydroxy acid 0.1%-0.5%, paeonol 0.5%-1.5%, purslane extract 2%-5%, notoginseng total saponins 1%-3%, ceramide NP 0.05%-0.2%, a complex of gingerol and avenant alkaloids 0.1%-1%, and a pharmaceutically or cosmetically acceptable base.

2. The body antipruritic and soothing composition according to claim 1, characterized in that: The preferred ratio of the active ingredients is: 0.3% menthyl hydroxy acid, 1.0% paeonol, 3.5% purslane extract, 2.0% total saponins of Panax notoginseng, 0.1% ceramide NP, and 0.5% complex of gingerol and avenant alkaloids.

3. The body antipruritic and soothing composition according to claim 2, characterized in that: The matrix is ​​a water-based gel matrix or an O / W emulsion matrix.

4. The body antipruritic and soothing composition according to claim 3, characterized in that: The specific steps include: S1. Under an inert gas atmosphere, heating the substrate to 35-45° C. and stirring to homogenize the substrate; S2. Maintaining an inert gas environment and stirring, cool the mixed system to 4-10°C; S3. Under low temperature conditions of 4-10°C, add purslane extract, Panax notoginseng saponins, ceramide NP, gingerol and oat alkaloid complex in sequence and perform high shear emulsification; S4. Add menthyl hydroxy acid and paeonol under continuous stirring at low temperature and stir evenly; S5. While stirring, the mixed system is subjected to dynamic vacuum degassing until the bubbles are completely eliminated to obtain the body antipruritic and soothing composition.

5. A mixing and preparing device for preparing the body antipruritic and soothing composition according to claim 4, characterized in that: include: A main mixing kettle (1) is provided with a feeding port (11) with a sealing cover on the top and a discharge valve (12) on the bottom; An inert gas supply system (2) is connected to the gas inlet (13) at the upper portion of the main mixing kettle (1) via a first pipeline (21), wherein the first pipeline (21) is provided with a first control valve (22); A temperature control system (3) comprising a jacket (31) wrapped around the outer wall of the main mixing kettle (1) and a semiconductor refrigeration unit (32) for providing cooling liquid to the jacket (31); A driving motor (41) is fixedly mounted at the center of the top of the main mixing kettle (1); A high shear emulsification mechanism (4) comprises a transmission shaft (42) driven by a driving motor (41) and an emulsification head (43) fixedly mounted on the end of the transmission shaft (42), wherein the emulsification head (43) is located inside the main mixing kettle (1); The vacuum degassing system (5) is connected to the air extraction port (14) at the top of the main mixing kettle (1) through a second pipeline (51), and a vacuum pump (52) and a second control valve (53) are sequentially provided on the second pipeline (51).

6. The mixing preparation device according to claim 5, characterized in that: The outlet of the discharge valve (12) is directly connected to the inlet of the filling equipment through a third pipeline (61), forming a closed discharge channel.

7. The mixing preparation device according to claim 6, characterized in that: A mechanical seal (44) is provided at the connection between the transmission shaft (42) of the high shear emulsification mechanism (4) and the top of the main mixing kettle (1); the emulsification head (43) is a stator-rotor structure and is located in the bottom center area of ​​the main mixing kettle (1).

8. The mixing preparation device according to claim 7, characterized in that: The mixing preparation device further comprises a control unit (6), which is electrically connected to the drive motor (41), the semiconductor refrigeration unit (32), the vacuum pump (52), the first control valve (22) and the second control valve (53), and is used to control the start and stop of the mixing preparation process, the temperature, the vacuum degree and the timing of the inert gas replacement.

9. The mixing preparation device according to claim 8, characterized in that: A temperature sensor (15) and a pressure sensor (16) connected to the control unit (6) are also provided in the main mixing kettle (1).

10. The mixing preparation device according to claim 9, characterized in that: The jacket (31) is a spiral guide plate type jacket (31), the coolant outlet of the semiconductor refrigeration unit (32) is connected to the inlet of the jacket (31) through a pump (33) and a fourth pipeline (34), and the outlet of the jacket (31) is returned to the semiconductor refrigeration unit (32) through a fifth pipeline (35).

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