A dissolving device for the pretreatment process of raw materials in heparin sodium production.

Abstract

This invention relates to the field of dissolving and stirring, and more particularly to a dissolving device for the pretreatment process of raw materials in heparin sodium production. The device includes a dissolving vessel, a driving mechanism connected to the dissolving vessel, a rotating tube connected to the driving mechanism, and a stirring paddle fixedly connected to the rotating tube. The stirring paddle is anchor-type, and two fixed covers are fixedly connected to the stirring paddle. Both fixed covers are arc-shaped, and each fixed cover has multiple cavities on its inner side, extending from front to back. Each cavity has an opening at one end, and the upper and lower inner walls of each cavity are provided with abrasive teeth. The driving mechanism is connected to two rotating shafts, and multiple rotating blocks are fixedly connected to each of the two rotating shafts. Multiple mating teeth are provided on the upper and lower surfaces of each rotating block. This device can utilize the stirring structure to grind the mucosa of pig small intestine, further improving the stirring efficiency.

Description

Technical Field

[0001] This invention relates to the field of dissolving and stirring, and more particularly to a dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium. Background Technology

[0002] Heparin sodium is an anticoagulant. The main raw material for processing heparin sodium is the small intestinal mucosa of pigs. Before processing heparin sodium, the pig small intestine needs to be pre-treated. Fresh pig small intestine is taken, and the mucosa is scraped off. Then, the small intestinal mucosa is minced into a paste using a crusher. The paste of small intestinal mucosa is then transferred to a mixer, and a 5.5% sodium chloride solution is added for stirring. This process of salt dissolution of the small intestinal mucosa promotes the separation of protein and heparin. This process requires multiple transfers of the small intestinal mucosa, which is time-consuming and labor-intensive, and increases the labor intensity of subsequent equipment cleaning. Summary of the Invention

[0003] In view of this, the technical problem to be solved by the present invention is to provide a dissolving device for the pretreatment process of raw materials for heparin sodium production. This device can use a stirring structure to mince the mucosa of pig small intestine, thereby further improving the stirring efficiency.

[0004] A dissolving device for the pretreatment process of raw materials in heparin sodium production includes a dissolving vessel, a driving mechanism connected to the dissolving vessel, a rotating tube connected to the driving mechanism, a stirring paddle fixedly connected to the rotating tube, the stirring paddle being anchor-type, and two fixed covers fixedly connected to the stirring paddle, both of which are arc-shaped, each of which has multiple cavities on its inner side, the cavities being interconnected front and back, each cavity having an opening at one end, and the upper and lower inner walls of the cavities being provided with agitator teeth; the driving mechanism is connected to two rotating shafts, each of which is fixedly connected with multiple rotating blocks, and the rotating blocks having multiple mating teeth on their upper and lower surfaces.

[0005] The cavity is trapezoidal, gradually widening from the opening end, and the rotating block is trapezoidal.

[0006] The drive mechanism includes a mounting base, on which a drive motor is fixedly connected. A first gear is fixedly connected to the output shaft of the drive motor. A rotating tube is rotatably connected to the mounting base, and a gear ring is fixedly connected to the upper end of the rotating tube. The first gear meshes with the gear ring for transmission.

[0007] The drive mechanism also includes an electric actuator, the moving end of which is fixedly connected to a lifting frame. Two rotating shafts are rotatably connected to the lifting frame, and a second gear is fixedly connected to the upper end of each of the two rotating shafts. Both second gears mesh with a gear ring for transmission.

[0008] The pitch circle radius of the gear ring is four times that of the pitch circle radius of the second gear.

[0009] An air cylinder is fixedly connected to the lower end of the rotating pipe, and multiple exhaust grooves are opened on the surface of the air cylinder.

[0010] Each rotating block surface is fixedly connected to a baffle.

[0011] Each baffle has a groove on its surface.

[0012] Each baffle is fixedly connected to a cleaning plate.

[0013] The beneficial effects of this application are as follows: By controlling the speed difference between the stirring paddle and the rotating block, a vortex superposition effect is formed within the cavity. This design can increase the fiber breakage rate of the small intestinal mucosa compared to traditional devices, while reducing the damage to intact tissue caused by mechanical stress. The specific surface area of ​​the pulverized material after grinding is larger than that of the original mucosa. Increasing the contact area can improve the salt dissolution rate. Attached Figure Description

[0014] The present invention will now be described in further detail with reference to the accompanying drawings and specific implementation methods.

[0015] Figure 1 This is a schematic diagram of the overall structure of a dissolving device used in the pretreatment process of raw materials for heparin sodium production;

[0016] Figure 2 This is a schematic diagram of the toothed ring structure;

[0017] Figure 3 This is a schematic diagram of the agitator.

[0018] Figure 4 This is a structural schematic diagram of the lifting frame;

[0019] Figure 5 This is a schematic diagram of the rotating shaft.

[0020] Figure 6 This is a schematic diagram of the block structure;

[0021] Figure 7 This is a schematic diagram of the exhaust channel structure;

[0022] Figure 8 This is a cross-sectional view of the air cylinder. Detailed Implementation

[0023] The present invention will be described in detail with reference to the accompanying drawings in the embodiments of the present invention.

[0024] A dissolving device for the pretreatment process of raw materials in the production of heparin sodium includes a dissolving vessel 101, a driving mechanism connected to the dissolving vessel 101, a rotating pipe 301 connected to the driving mechanism, a stirring paddle 304 fixedly connected to the rotating pipe 301, the stirring paddle 304 being anchor-type, and two fixed covers 401 fixedly connected to the stirring paddle 304, both of the fixed covers 401 being arc-shaped, and multiple cavities 402 being opened on the inner side of each of the two fixed covers 401, the cavities 402 being through the front and back, and an opening 404 being provided at one end of each cavity 402, and a material-gripping tooth 403 being provided on the upper and lower inner walls of each cavity 402, and two rotating shafts 501 connected to the driving mechanism, and multiple rotating blocks 502 being fixedly connected to each of the two rotating shafts 501, with multiple mating teeth 503 provided on the upper and lower surfaces of each rotating block 502.

[0025] The cavity 402 is trapezoidal, gradually widening from the opening 404 end, and the rotating block 502 is trapezoidal.

[0026] The drive mechanism includes a mounting base 201, on which a drive motor 203 is fixedly connected. A first gear 202 is fixedly connected to the output shaft of the drive motor 203. A rotating tube 301 is rotatably connected to the mounting base 201. A gear ring 204 is fixedly connected to the upper end of the rotating tube 301. The first gear 202 meshes with the gear ring 204 for transmission.

[0027] The drive mechanism also includes an electric push rod 102, the moving end of which is fixedly connected to a lifting frame 103. Two rotating shafts 501 are rotatably connected to the lifting frame 103. The upper ends of the two rotating shafts 501 are fixedly connected to a second gear 104, and the two second gears 104 mesh with a gear ring 204 for transmission.

[0028] The pitch circle radius of the gear ring 204 is four times that of the pitch circle radius of the second gear 104.

[0029] The lower end of the rotating pipe 301 is fixedly connected to an air cylinder 302, and the surface of the air cylinder 302 is provided with multiple exhaust grooves 303.

[0030] Each rotating block 502 surface is fixedly connected with a baffle 504.

[0031] Each baffle 504 has a groove 505 on its surface.

[0032] Each baffle 504 is fixedly connected to a cleaning plate 506.

[0033] Each cleaning disc 506 has the ability to deform elastically.

[0034] See Figure 1-5 ,

[0035] When using the dissolving device, the operator first adds the cleaned pig small intestine mucosa to the dissolving vessel 101, and then adds a 5.5% sodium chloride solution to the dissolving vessel 101. Then, the first gear 202 is driven to rotate by the drive motor 203. The first gear 202 meshes with the gear ring 204, which drives the rotating tube 301 to rotate. The rotating tube 301 drives the stirring paddle 304 to rotate. The stirring paddle 304 can achieve the effect of stirring the pig small intestine mucosa and the sodium chloride solution. The sodium chloride solution is used to dissolve the pig small intestine mucosa, which promotes the separation of protein and heparin.

[0036] See Figure 8 ,

[0037] Because the 304 agitator is an anchor type, the anchor type agitator generates turbulence through rotation, which can quickly break up liquid stratification and promote material mixing. It is especially suitable for stirring and treating pig small intestine mucosa and sodium chloride solution. The tight fit between the outer edge of its blade and the inner wall of the container and the small gap can also remove solid or sticky products adhering to the wall surface and avoid uneven local concentration.

[0038] The gear ring 204 can simultaneously drive two second gears 104 to rotate synchronously. The two second gears 104 drive two rotating shafts 501 to rotate synchronously, and the two rotating shafts 501 drive multiple rotating blocks 502 to rotate. Since the pitch circle radius of the gear ring 204 is four times the pitch circle radius of the second gear 104, it can accelerate the rotation of the two rotating shafts 501, and the rotation speed of the two rotating shafts 501 is greater than the rotation speed of the rotating shafts 502.

[0039] See Figure 5-6 ,

[0040] When the stirring paddle 304 is stirring the small intestinal mucosa and sodium chloride solution, multiple rotating blocks 502 rotate around the axis of the rotating shaft 501. Thus, the multiple rotating blocks 502 can also stir the small intestinal mucosa and sodium chloride solution. Utilizing the speed difference between the rotating shaft 501 and the rotating tube 301, the rotating blocks 502 and the stirring paddle 304 work together to produce a shearing effect on the material. This achieves the effect of shearing and crushing while stirring the small intestinal mucosa, allowing the small intestinal mucosa to come into full contact with the sodium chloride solution and improving the salt dissolution effect. Compared with the conventional method of crushing first and then stirring, this method can effectively save time, avoid multiple material transfers, and reduce labor and equipment cleaning difficulties.

[0041] During the rotation of the agitator 304, the fixed cover 401 is arc-shaped, which can reduce the rotational resistance of the agitator 304. The material can pass through the multiple cavities 402 on the fixed cover 401, which can further reduce the rotational resistance of the agitator 304. At the same time, the fixed cover 401 and the multiple cavities 402 work together to reduce the stirring resistance and enhance the propulsion force, which can prevent material splashing and gas entrainment.

[0042] See Figure 7 ,

[0043] Since the cavity 402 is open from front to back, and an opening 404 is provided at one end of the cavity 402, and the cavity 402 is trapezoidal and gradually widens from the opening 404 end, and the rotating block 502 is also trapezoidal, when the stirring paddle 304 and the multiple rotating blocks 502 rotate, the multiple rotating blocks 502 can enter the multiple cavities 402 of the stirring paddle 304 respectively. The mating teeth 503 on the surface of the rotating block 502 and the abrasive teeth 403 inside the cavity 402 cooperate. When the mating teeth 503 and the abrasive teeth 403 move relative to each other, they can tear the small intestinal mucosa between them. And under differential rotation, it can achieve the function of abrasiveing ​​the small intestinal mucosa inside the cavity 402, further refining the small intestinal mucosa, making the small intestinal mucosa eroded, and promoting the dissolution of small intestinal mucosal salts.

[0044] The trapezoidal cavity 402, with its gradually widening opening, combined with the geometric matching of the trapezoidal rotating block 502, forms a progressive shredding space. This design effectively controls the material flow direction. When the agitator 304 and the rotating block 502 rotate at different speeds, a spiral shearing flow field is formed inside the cavity. The relative motion between the teeth 503 and the shredding teeth 403 generates multi-stage shearing forces, improving shearing efficiency compared to traditional single-blade structures.

[0045] By controlling the speed difference between the stirring paddle and the rotating block, a superposition effect of vortices is created within the cavity. This design increases the fiber breakage rate of the small intestinal mucosa compared to traditional devices, while reducing the damage to intact tissue caused by mechanical stress. The specific surface area of ​​the pulverized material is larger than that of the original mucosa. Increasing the contact area can improve the salt dissolution rate.

[0046] See Figure 7-8 ,

[0047] During the stirring and grinding of the small intestinal mucosa, air is transmitted into the rotating tube 301 by rotating the exhaust pipe of the air pump. The air enters the air cylinder 302 and is then discharged through multiple exhaust slots 303. The air pressure increases as it passes through the multiple exhaust slots 303, thereby impacting the surrounding small intestinal mucosa and sodium chloride solution. In addition, the rotation of the air cylinder 302 helps to diffuse the solution to the surrounding area, preventing it from concentrating in the middle of the dissolving vessel 101 and further improving the stirring effect.

[0048] See Figure 6 ,

[0049] Since each rotating block 502 is fixedly connected with a baffle 504, when the rotating block 502 rotates, it drives the baffle 504 to move. The multiple baffles 504 correspond to the positions of multiple exhaust grooves 303 respectively. When the baffle 504 rotates to the position of the exhaust groove 303, the baffle 504 can block the exhaust groove 303 and leave a gap between them. The air discharged from the exhaust groove 303 breaks into bubbles after contacting the baffle 504 and diffuses to the surroundings, thereby further expanding the range of bubble stirring.

[0050] The groove 505 on the baffle 504 causes the generated bubbles to further split. After the bubbles are discharged, they collide with the groove 505 on the baffle 504, causing them to split into smaller bubbles, thus making the mixing effect of the bubbles more uniform.

[0051] Multiple cleaning discs 506 correspond to multiple exhaust grooves 303. When the rotating block 502 drives the cleaning discs 506 to contact the exhaust grooves 303, the cleaning discs 506 can be inserted into the exhaust grooves 303, thereby preventing small intestinal mucosal tissue from getting stuck in the exhaust grooves 303 and avoiding blockage, thus ensuring exhaust efficiency. Since the multiple cleaning discs 506 are all made of rubber, they all have elastic deformation capabilities. When the cleaning discs 506 come into contact with the surface of the air cylinder 302, they can automatically deform. When the cleaning discs 506 enter the exhaust grooves 303, they can automatically reset according to their own elasticity, avoiding hard contact between the cleaning discs 506 and the air cylinder 302.

[0052] See Figure 2-3 ,

[0053] After the small intestinal mucosa is dissolved with salt, multiple rotating blocks 502 are controlled to detach from multiple cavities 402 respectively. The operator controls the moving end of the electric push rod 102 to extend, thereby driving the lifting frame 103 to move upward. The lifting frame 103 drives two second gears 104 to detach upward from the gear ring 204, and at the same time drives two rotating shafts 501 and multiple rotating blocks 502 to detach from the dissolving vessel 101.

[0054] Since the two second gears 104 disengage from the gear ring 204 at this time, when the gear ring 204 is rotated again, the gear ring 204 only drives the stirring paddle 304 to stir the small intestinal mucosa. At this time, sodium hydroxide solution is added to the small intestinal mucosa so that the small intestinal mucosa and sodium hydroxide solution are fully mixed, and the proteins in the small intestinal mucosa are denatured to avoid heparin degradation.

[0055] In this process, the rotating block 502 and the stirring paddle 304 are no longer used to grind the small intestinal mucosa. Through the above operation, the two second gears 104 are disengaged from the gear ring 204, thereby reducing the power loss during the rotation of the gear ring 204, further saving resources and improving the stirring efficiency.

Claims

1. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium, characterized in that: The apparatus includes a dissolving vessel, a drive mechanism connected to the dissolving vessel, a rotating tube connected to the drive mechanism, and a stirring paddle fixedly connected to the rotating tube. The stirring paddle is anchor-type, and two fixed covers are fixedly connected to the stirring paddle. Both fixed covers are arc-shaped, and multiple cavities are opened on the inner side of each fixed cover. The cavities are connected to each other from front to back, and each cavity has an opening at one end. The upper and lower inner walls of the cavity are provided with agitator teeth. The drive mechanism is connected to two rotating shafts, and multiple rotating blocks are fixedly connected to each of the two rotating shafts. The rotating blocks have multiple mating teeth on their upper and lower surfaces. The cavity is trapezoidal, gradually widening from the opening end, and the rotating blocks are trapezoidal.

2. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 1, characterized in that: The drive mechanism includes a mounting base, on which a drive motor is fixedly connected. A first gear is fixedly connected to the output shaft of the drive motor. A rotating tube is rotatably connected to the mounting base, and a gear ring is fixedly connected to the upper end of the rotating tube. The first gear meshes with the gear ring for transmission.

3. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 2, characterized in that: The drive mechanism also includes an electric actuator, the moving end of which is fixedly connected to a lifting frame. Two rotating shafts are rotatably connected to the lifting frame, and a second gear is fixedly connected to the upper end of each of the two rotating shafts. Both second gears mesh with a gear ring for transmission.

4. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 3, characterized in that: The pitch circle radius of the gear ring is four times that of the pitch circle radius of the second gear.

5. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 4, characterized in that: An air cylinder is fixedly connected to the lower end of the rotating pipe, and multiple exhaust grooves are opened on the surface of the air cylinder.

6. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 1, characterized in that: Each rotating block surface is fixedly connected to a baffle.

7. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 6, characterized in that: Each baffle has a groove on its surface.

8. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 7, characterized in that: Each baffle is fixedly connected to a cleaning plate.

9. A dissolving apparatus for the pretreatment process of raw materials in the production of heparin sodium according to claim 8, characterized in that: Each cleaning plate has the ability to deform elastically.

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