Efficient synthesis device of nicotinamide riboside chloride

Abstract

The invention discloses an efficient synthesis device of nicotinamide riboside chloride, and relates to the technical field of synthesis devices, the efficient synthesis device comprises a reaction cylinder, a lifting stirring assembly, a circulating flow guide assembly, a filtration detection assembly, a backflushing assembly, a stepped temperature adjustment assembly and a valve assembly. The filter detection assembly comprises a rotatable filter plate and a filter screen, and the crystal content is monitored in real time through the rotation amplitude of the filter plate; when crystallization reaches the standard, the linkage valve assembly automatically discharges materials, and meanwhile the step type temperature adjusting assembly adjusts the refrigeration intensity according to the crystallization process. The backflushing assembly can prevent the filter screen from being blocked, and the circulating flow guide assembly strengthens mixing of reaction liquid. The device solves the problems that a traditional device is delayed in crystallization monitoring, extensive in temperature control, insufficient in synthetic reaction and low in crystallization efficiency, realizes automatic control of the crystallization process, and remarkably improves the product purity and the production efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of synthesis device, and particularly relates to a high-efficiency synthesis device for nicotinamide riboside chloride. BACKGROUND

[0002] Nicotinamide riboside chloride is a chloride of nicotinamide ribose, which is stable at room temperature and has the same function as nicotinamide ribose. When nicotinamide riboside chloride is synthesized, the crude nicotinamide riboside chloride needs to be dissolved in ethyl acetate for recrystallization, and the nicotinamide riboside chloride product is obtained by drying. As an important pharmaceutical intermediate, the synthesis efficiency and purity of nicotinamide riboside chloride directly affect the product quality.

[0003] The existing synthesis device has the following defects when actually used: the crystallization process lacks real-time monitoring, which can easily lead to insufficient reaction or excessive crystallization, unstable product purity, and some devices with independent detection of the crystallization process cannot automatically adjust the crystallization reaction temperature according to the detection results after detection, affecting the efficient progress of the crystallization reaction and reducing the crystallization efficiency. Therefore, there is an urgent need for a high-efficiency synthesis device that can accurately control the temperature and real-time monitor the crystallization state. SUMMARY

[0004] The present application provides a high-efficiency synthesis device for nicotinamide riboside chloride, which solves the problem of the existing synthesis device that cannot accurately monitor the progress of the crystallization reaction and flexibly control the crystallization temperature, and has low synthesis reaction efficiency.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical scheme:

[0006] A high-efficiency synthesis device for nicotinamide riboside chloride, comprising a reaction cylinder, a lifting stirring assembly is arranged on the reaction cylinder, a circulating flow guide assembly is arranged on both sides of the stirring cylinder, a filter detection assembly is arranged on both sides of the lifting stirring assembly, the filter detection assembly comprises a filter plate rotatably arranged on the inner wall of the reaction cylinder, a filter screen is arranged on one side of the bottom end of the filter plate, a backflushing assembly is arranged on the filter detection assembly, the backflushing assembly comprises a backflushing gas outlet pipe arranged on one side below the filter screen, a stepped temperature adjusting assembly is arranged outside the reaction cylinder, a valve assembly is arranged at the discharge end of the reaction cylinder, the valve assembly is connected with the filter detection assembly, the filter detection assembly controls the valve assembly to discharge in real time when the crystallization content meets the standard, and a drying box is arranged at the discharge end of the valve assembly; wherein the filter plate in the filter detection assembly rotates to monitor the crystallization content in real time; when the crystallization meets the standard, the valve assembly is automatically discharged, and the stepped temperature adjusting assembly adjusts the refrigeration intensity according to the crystallization process, and the circulating flow guide assembly strengthens the mixing of the reaction liquid, so that the crystallization synthesis reaction efficiency is higher.

[0007] As a preferred technical scheme of the present application, the lifting stirring assembly comprises electric telescopic rods fixedly arranged on both sides of the top of the stirring cylinder, the telescopic ends of the electric telescopic rods are fixedly connected with fixed arms, the fixed arms are fixedly connected with lifting beams on both sides, the lifting beams are fixedly connected with stirring motors, the output shaft ends of the stirring motors are fixedly connected with stirring columns, the stirring columns extend into the reaction cylinder and are fixedly connected with stirring blades on the bottom end side wall, the driving blocks are rotatably arranged on the stirring columns above the reaction cylinder, the driving blocks are hingedly connected with linkage rods on both sides, the linkage rods are hingedly connected with push rods on the end portions, the push rods are slidingly arranged on the top wall of the reaction cylinder, the stirring blades on the stirring columns move up and down to stir, the stirring is more sufficient, and the stirring efficiency is higher.

[0008] As a preferred technical scheme of the present application, the circulating flow guide assembly comprises flow guide cylinders arranged on both sides of the reaction cylinder, a feeding pipe is arranged between the feeding end of the flow guide cylinder and the discharging end of the reaction cylinder, a discharging pipe is arranged above the feeding pipe, one end of the discharging pipe is connected with the discharging end of the flow guide cylinder, and the other end extends above the reaction cylinder and penetrates through the top wall of the reaction cylinder and is arranged correspondingly with the filter plate, a piston block is slidingly arranged in the flow guide cylinder, the piston block is fixedly connected with a lifting column on the top portion, and the lifting column is fixedly connected with the lifting beam on the top portion.

[0009] As a preferred technical scheme of the present application, a one-way feeding valve is arranged at the connection position between the feeding end of the flow guide cylinder and the feeding pipe, and a one-way discharging valve is arranged at the connection position between the discharging end of the flow guide cylinder and the discharging pipe; under the action of the flow guide cylinder, the up-and-down circulation flow of the reaction liquid is promoted, and the mixing effect is further improved.

[0010] As a preferred technical scheme of the present application, the filter detection assembly further comprises a lifting rod slidingly and penetratingly arranged on the top wall of the reaction cylinder, a transmission groove is formed in the side wall of the filter plate on one side of the bottom end of the lifting rod, the end portion of the lifting rod is movably connected with the filter plate through the transmission groove, a linkage arm is fixedly connected with the top portion of the lifting rod, a piston column is arranged between the linkage arm and the reaction cylinder, a compression member is sleeved on the telescopic end of the piston column, and the top portion of the telescopic end of the piston column is fixedly connected with the linkage arm.

[0011] As a preferred technical scheme of the present application, a stop block is fixedly connected with the top portion of the linkage arm, a movable column is slidingly and penetratingly arranged on the push rod on one side of the stop block, a reset member is sleeved on the movable column, a vertical rod is fixedly connected with the reaction cylinder on the side of the stop block away from the push rod, a pneumatic telescopic cylinder is fixedly connected with the vertical rod, the telescopic end of the pneumatic telescopic cylinder is correspondingly arranged with the movable column, and the gas outlet end of the pneumatic telescopic cylinder is connected with a gas transmission pipe.

[0012] As a preferred technical scheme of the present application, the valve assembly comprises a guide shell fixedly arranged at the discharge end of the reaction cylinder, air conveying cylinders fixedly connected on both sides of the guide shell, the air inlet end of the air conveying cylinder being connected with the air conveying pipe, a push block slidingly arranged in the air conveying cylinder, a support fixedly connected between the push block and the guide shell, a valve rod fixedly connected on the side wall of the push block, the valve rod being horizontally movably arranged on the guide shell, and a valve opening being formed in the valve rod.

[0013] As a preferred technical scheme of the present application, the backflushing assembly further comprises a guide shell fixedly arranged on the vertical rod, the air inlet end of the guide shell being fixedly connected with the air supply pump, an active groove being formed in the guide shell, a sealing block slidingly arranged in the active groove, an extension piece fixedly connected on the side wall of the sealing block, an active rod fixedly connected at one end of the extension piece, the active rod extending to the outside of the guide shell, a push rod fixedly connected on the side wall of the active rod, the air outlet end of the guide shell being connected with the air guide pipe, the air guide pipe penetrating through the side wall of the reaction cylinder and being connected at the end with the air inlet end of the backflushing air outlet pipe.

[0014] As a preferred technical scheme of the present application, the stepped temperature regulating assembly comprises a transmission cylinder arranged outside the reaction cylinder, the bottom of the transmission cylinder being fixedly connected with the drying box, a transmission gear being rotatably arranged in the transmission cylinder, a driving rod and a transmission rod slidingly arranged in the transmission cylinder on both sides of the transmission gear, a rack being arranged on the side of the driving rod and the transmission rod close to the transmission gear and being engaged with the transmission gear, a trapezoidal rod being fixedly connected at the side of the transmission rod away from the driving rod, a plurality of refrigerators being fixedly connected on the outer wall of the transmission cylinder at the side of the trapezoidal rod, a refrigeration switch being arranged on the inner wall of the transmission cylinder at the side of the refrigerators, the refrigeration switch corresponding to the trapezoidal rod, and the output end of the refrigerators being connected with the reaction cylinder.

[0015] As a preferred technical scheme of the present application, the drying box is fixedly connected with the driers on both sides, the discharge end of the drying box is provided with a discharge pipe, and the moisture in the crystallization material can be quickly dried under the action of the driers to obtain the crystallization raw material.

[0016] The present application has the following advantages: the lifting stirring assembly: through the rotation and lifting movement of the lifting stirring assembly, three-dimensional mixing of the reaction liquid is realized, precipitation is avoided, and reaction uniformity is improved; the circulating flow guide assembly: the reaction liquid is forced to flow from bottom to top, the mass transfer efficiency is enhanced, and the crystallization process is accelerated; the filter detection assembly dynamically monitors, the filter plate rotates with the increase of the crystallization amount, the crystallization content is converted into a mechanical displacement signal, when the crystallization reaches the standard, the filter plate displacement triggers the valve assembly to automatically discharge, over-crystallization is prevented, and immediate discharge improves the efficiency of the synthesis reaction.

[0017] The stepped temperature regulating assembly can gradually reduce the refrigeration intensity according to the crystallization process, the initial rapid cooling promotes crystallization, the later slow reduction preserves the purity, optimizes the crystallization conditions, and ensures the normal progress of the crystallization reaction. When the filter detection assembly directly controls the opening and closing of the valve, the detection-discharging synchronization is realized, the automation degree is improved, and the overall efficiency of the synthesis reaction is also improved to a certain extent. Overall advantages: integrated monitoring, temperature control, anti-blocking, and discharging functions, which significantly improve the crystallization purity and production efficiency

[0018] Overall, the device can accurately monitor and control the crystallization reaction process, provide a better temperature environment for the crystallization synthesis reaction, and realize the automatic control of the crystallization process. The raw material mixing is more sufficient during the crystallization synthesis reaction process, which significantly improves the product purity and production efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 Structure diagram of a high-efficiency synthesis device for nicotinamide riboside chloride Figure One .

[0020] Figure 2 Structure diagram of a high-efficiency synthesis device for nicotinamide riboside chloride Figure Two .

[0021] Figure 3 Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride.

[0022] Figure 4 Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 3

[0023] Figure 5 Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride.

[0024] Figure 6 Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 5

[0025] Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 7

[0026] Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 8

[0027] Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 9

[0028] Structure diagram of the internal whole of a high-efficiency synthesis device for nicotinamide riboside chloride. Figure 10

[0029] ​​In the figure: 1, reaction cylinder; 2, drying box; 3, dryer; 4, circulating guide assembly; 401, guide cylinder; 402, piston block; 403, lifting column; 404, discharge pipe; 405, feeding pipe; 5, lifting stirring assembly; 501, lifting beam; 502, electric telescopic rod; 503, stirring column; 504, linkage rod; 505, fixed arm; 506, stirring motor; 507, driving block; 508, stirring blade; 509, pushing rod; 6, backflushing assembly; 601, air supply pump; 602, air guide shell; 603, air guide pipe; 604, movable rod; 605, push rod; 606, telescopic part; 607, sealing block; 608, movable groove; 609, backflushing air outlet pipe; 7, filtering and detecting assembly; 701, lifting rod; 702, piston column; 703, compression part; 704, linkage arm; 705, reset part; 706, stop block; 707, movable column; 708, pneumatic telescopic cylinder; 709, air transmission pipe; 710, filter plate; 711, transmission groove; 712, filter screen; 8, stepped temperature adjusting assembly; 801, transmission cylinder; 802, driving rod; 803, transmission rod; 804, refrigerating device; 805, transmission gear; 806, trapezoidal rod; 807, refrigerating switch; 9, valve assembly; 901, material guide shell; 902, pushing block; 903, air transmission cylinder; 904, valve rod; 905, support part; 906, valve port; 10, discharge pipe; 11, vertical rod; 12, ingredient pipe. DETAILED DESCRIPTION

[0030] The preferred embodiments of the present application will be described below in conjunction with the accompanying drawings, and it should be understood that the preferred embodiments described herein are only used to explain and illustrate the present application, and are not used to limit the present application.

[0031] Please refer to Figures 1-10 As an embodiment of the present application, a high-efficiency synthesis device for nicotinamide riboside chloride includes a reaction cylinder 1, the side wall of the reaction cylinder 1 is fixedly connected with an ingredient pipe 12, a lifting stirring assembly 5 is arranged on the reaction cylinder 1, circulating guide assemblies 4 are arranged on both sides of the reaction cylinder 1, a filtering and detecting assembly 7 is arranged on the reaction cylinder 1 on both sides of the lifting stirring assembly 5, the filtering and detecting assembly 7 includes a filter plate 710 rotatably arranged on the inner wall of the reaction cylinder 1, a filter screen 712 is arranged on one side of the bottom end of the filter plate 710, a backflushing assembly 6 is arranged on the filtering and detecting assembly 7, the backflushing assembly 6 includes a backflushing air outlet pipe 609 arranged on one side below the filter screen 712, a stepped temperature adjusting assembly 8 is arranged outside the reaction cylinder 1, a valve assembly 9 is arranged at the discharge end of the reaction cylinder 1, the valve assembly 9 is connected with the filtering and detecting assembly 7, the filtering and detecting assembly 7 controls the valve assembly 9 to discharge in real time when the crystallization content reaches the standard, and a drying box 2 is arranged at the discharge end of the valve assembly 9.

[0032] In actual use, the filter plate 710 in the filter detection assembly 7 rotates to monitor the crystallization content in real time; when the crystallization is qualified, the linkage valve assembly 9 automatically discharges, the stepped temperature adjusting assembly 8 adjusts the refrigeration strength according to the crystallization process, and the circulating flow guide assembly 4 strengthens the mixing of the reaction liquid. The problems of the traditional device, such as crystallization monitoring lag, rough temperature control, insufficient synthesis reaction, and low crystallization efficiency, are solved, the automatic control of the crystallization process is realized, and the product purity and production efficiency are significantly improved.

[0033] Please refer to Figures 1-10 As another embodiment of the present application, the lifting stirring assembly 5 comprises electric telescopic rods 502 fixedly arranged on both sides of the top of the reaction cylinder 1, the telescopic ends of the electric telescopic rods 502 are fixedly connected with fixed arms 505, the fixed arms 505 are fixedly connected with lifting beams 501 on both sides, the lifting beams 501 are fixedly connected with stirring motors 506, the output shaft ends of the stirring motors 506 are fixedly connected with stirring columns 503, the stirring columns 503 extend into the reaction cylinder 1 and are fixedly connected with stirring blades 508 on the bottom end side wall, the driving blocks 507 are rotatably sleeved on the stirring columns 503 above the reaction cylinder 1, the driving blocks 507 are hingedly connected with linkage rods 504 on both sides, the linkage rods 504 are hingedly connected with push rods 509 at the ends, and the push rods 509 are slidingly arranged on the top wall of the reaction cylinder 1. In actual use, the electric telescopic rods 502 can drive the lifting beams 501 to move up and down, and when the stirring motors 506 drive the stirring columns 503 to rotate, the stirring blades 508 can be rotated up and down for stirring. This stirring mode is more comprehensive and thorough, and the stirring and mixing effect is better.

[0034] The circulating flow guide assembly 4 comprises flow guide cylinders 401 arranged on both sides of the reaction cylinder 1, a feeding pipe 405 is arranged between the feeding end of the flow guide cylinder 401 and the discharging end of the reaction cylinder 1, a discharging pipe 404 is arranged above the feeding pipe 405, one end of the discharging pipe 404 is connected with the discharging end of the flow guide cylinder 401, the other end extends above the reaction cylinder 1 and penetrates through the top wall of the reaction cylinder 1, and is arranged corresponding to the filter plate 710. A piston block 402 is slidingly arranged in the flow guide cylinder 401, the piston block 402 is fixedly connected with a lifting column 403 on the top, and the lifting column 403 is fixedly connected with the lifting beam 501 on the top. A one-way feeding valve is arranged at the connection between the feeding end of the flow guide cylinder 401 and the feeding pipe 405, and a one-way discharging valve is arranged at the connection between the discharging end of the flow guide cylinder 401 and the discharging pipe 404. In actual use, when the piston block 402 moves upward, the one-way feeding valve at the end of the feeding pipe 405 is opened to suck the reaction liquid in the reaction cylinder 1 into the flow guide cylinder 401, and when the piston block 402 moves downward, the one-way discharging valve on the discharging pipe 404 is opened, and the reaction liquid is discharged from the discharging pipe 404. The above process can realize the upward flow of the reaction liquid, the mixing effect of the liquid is better, and the efficiency of the stirring and crystallization is further improved.

[0035] The filter detection assembly 7 further comprises a lifting rod 701 slidingly penetrating the top wall of the reaction cylinder 1, a transmission groove 711 being formed in the side wall of a filter plate 710 at one side of the bottom end of the lifting rod 701, the end of the lifting rod 701 being movably connected with the filter plate 710 through the transmission groove 711, a linkage arm 704 being fixedly connected with the top of the lifting rod 701, a piston column 702 being arranged between the linkage arm 704 and the reaction cylinder 1, a compression member 703 being sleeved on the telescopic end of the piston column 702, and the top of the telescopic end of the piston column 702 being fixedly connected with the linkage arm 704.

[0036] The top of the linkage arm 704 is fixedly connected with a stop block 706, an active column 707 being slidingly penetratingly arranged on a push rod 509 at one side of the stop block 706, a reset member 705 being sleeved on the active column 707, a vertical rod 11 being fixedly connected with the reaction cylinder 1 at the side of the stop block 706 away from the push rod 509, a pneumatic telescopic cylinder 708 being fixedly connected with the vertical rod 11, the telescopic end of the pneumatic telescopic cylinder 708 being correspondingly arranged with the active column 707, and the gas outlet end of the pneumatic telescopic cylinder 708 being connected with a gas transmission pipe 709; in actual use, when the stop block 706 moves downward to below the active column 707, it indicates that the crystallization amount meets the standard, and before the standard is met, the stop block 706 will always block at one side of the active column 707, so that the stirring and crystallization operation can be ensured to be continuously performed.

[0037] The valve assembly 9 comprises a material guide shell 901 fixedly arranged at the discharge end of the reaction cylinder 1, gas transmission cylinders 903 being fixedly connected with the material guide shell 901 at both sides, the gas inlet end of the gas transmission cylinders 903 being connected with the gas transmission pipe 709, a push block 902 being slidingly arranged in the gas transmission cylinders 903, a support member 905 being fixedly connected between the push block 902 and the material guide shell 901, a valve rod 904 being fixedly connected with the side wall of the push block 902 and being movably arranged on the material guide shell 901 in the transverse direction, and a valve opening 906 being formed in the valve rod 904; after the reaction is completed, the active column 707 pushes the pneumatic telescopic cylinder 708, and then pushes the valve rod 904 on the material guide shell 901 to move, so that the reaction material falls into the drying box 2.

[0038] The backflush assembly 6 comprises a gas guide shell 602 fixedly arranged on the vertical rod 11, the gas inlet end of the gas guide shell 602 being fixedly connected with a gas supply pump 601, an active groove 608 being formed in the gas guide shell 602, a sealing block 607 being slidingly arranged in the active groove 608, a telescopic member 606 being fixedly connected with the side wall of the sealing block 607, an active rod 604 being fixedly connected with one end of the telescopic member 606 and extending to the outside of the gas guide shell 602, a push rod 605 being fixedly connected with the side wall of the push rod 509 at one side of the active rod 604, the gas outlet end of the gas guide shell 602 being connected with a gas guide pipe 603, and the gas guide pipe 603 penetrating the side wall of the reaction cylinder 1 and being connected with the gas inlet end of a backflush gas outlet pipe 609 at the end; the filtered crystallization material can be timely discharged through the backflush gas outlet pipe 609.

[0039] The stepped temperature adjusting assembly 8 comprises a transmission cylinder 801 arranged outside the reaction cylinder 1, the bottom of the transmission cylinder 801 is fixedly connected with the drying box 2, a transmission gear 805 is rotatably arranged in the transmission cylinder 801, a driving rod 802 and a transmission rod 803 are slidably arranged in the transmission cylinder 801 at the two sides of the transmission gear 805, the driving rod 802 and the transmission rod 803 are provided with a rack close to one side of the transmission gear 805, the rack is engaged with the transmission gear 805, one side of the transmission rod 803 away from the driving rod 802 is fixedly connected with a trapezoidal rod 806, the outer wall of the transmission cylinder 801 at one side of the trapezoidal rod 806 is fixedly connected with a refrigerating device 804, a plurality of refrigerating devices 804 are arranged, the inner wall of the transmission cylinder 801 at one side of the refrigerating device 804 is provided with a refrigerating switch 807, the refrigerating switch 807 corresponds to the trapezoidal rod 806, and the output end of the refrigerating device 804 is connected with the reaction cylinder 1; in the initial state, the refrigerating device 804 is opened in the largest number, in this case, the high-speed rapid cooling can be maintained, and the temperature requirement in the initial stage of crystallization is met, along with the progress of the reaction, the stepped temperature adjusting assembly 8 can reduce the cooling rate, until the final cooling is not performed, and the whole process can provide a relatively appropriate temperature condition for the crystallization reaction, and promote the efficient progress of the crystallization reaction.

[0040] The drying box 2 is fixedly connected with the drying device 3 at the two sides, the bottom of the flow guide cylinder 401 is fixedly arranged on the drying device 3, and the discharge end of the drying box 2 is provided with a discharge pipe 10, wherein the discharge end of the guide shell 901 is communicated with the feeding end of the drying box 2.

[0041] In the implementation process of the present application, the reaction raw materials are added into the reaction cylinder 1 through the batching pipe 12, and then the stirring motor 506 is started to drive the stirring column 503 to rotate, and the stirring column 503 drives the stirring blades 508 to realize the mixing and stirring of the raw materials. During the stirring process, the raw materials react with each other to start crystallization. At the same time, under the action of the electric telescopic rod 502, the fixed arm 505 can drive the lifting beam 501 to move up and down, and then drive the stirring blades 508 to move up and down for stirring, so that the stirring effect is better. During the up-and-down movement of the lifting beam 501, the lifting column 403 can be driven to move up and down, and the piston block 402 at the bottom of the lifting column 403 moves up and down. Under the action of the feeding pipe 405 and the discharging pipe 404, the reactants are first sucked into the flow guide cylinder 401, and then flow into the reaction cylinder 1 above the filter plate 710 through the discharging pipe 404. Under the action of the filter screen 712, the filtering is realized. The liquid reaction raw materials flowing in a single cycle in this process are quantified. Since the reaction of the reaction materials will produce crystallization, the filter screen 712 will filter out the crystallization after filtering. The crystallization is located on the filter screen 712 on one side of the filter plate 710. In this case, under the action of the weight of the crystallization itself, the filter plate 710 will rotate, and then drive the lifting rod 701 to move down. The lifting rod 701 drives the linkage arm 704 to move down, and the linkage arm 704 drives the stop block 706 to move down. After the filtering is completed, when the stirring column 503 drives the driving block 507 to move up, the linkage rod 504 can drive the push rod 509 to move under the action of the linkage rod 504. The push rod 605 on the push rod 509 moves and contacts the movable rod 604. The movable rod 604 drives the sealing block 607 to move through the telescopic piece 606. The sealing block 607 moves away from the flow guide passage of the air guide shell 602. Therefore, the air supply pump 601 can send gas into the backflushing gas pipe 609 through the air guide pipe 603. The backflushing gas pipe 609 blows out the crystallization material on the filter screen 712. The crystallization material is mixed with the reaction liquid again. In the initial stage, since the reaction is not complete enough, the content of the crystallization material in a certain amount of reaction liquid is relatively small. Therefore, the filter plate 710 drives the stop block 706 above the linkage arm 704 to move down by a smaller amplitude. Therefore, when the push rod 509 drives the movable column 707 to move, it will be blocked by the stop block 706 and cannot contact the pneumatic telescopic cylinder 708. This indicates that the crystallization of the reaction liquid has not been completed at this time. At the same time, during the downward movement of the linkage arm 704, the driving rod 802 is driven to move down. Under the action of the transmission gear 805, the transmission rod 803 can be driven to move up. Therefore, during the upward movement of the trapezoidal rod 806, the trapezoidal rod 806 can be separated from the refrigeration switch 807. Therefore, the number of open refrigerators 804 is reduced, the cooling rate is gradually reduced, and the function of stepwise cooling is realized, thereby further improving the crystallization rate. When the amount of crystallization reaches the standard, the filter plate 710 drives the lifting rod 701 to move down by a larger amplitude. At the same time, the stop block 706 moves down to below the movable column 707. When the push rod 509 moves, it can drive the movable column 707 to contact the telescopic end of the pneumatic telescopic cylinder 708.The gas of the pneumatic telescopic cylinder 708 is sent into the air conveying cylinder 903 through the air conveying pipe 709, the pushing block 902 in the air conveying cylinder 903 drives the valve rod 904 to move, the valve port 906 on the valve rod 904 is in correspondence with the discharging passage of the material guiding shell 901, at this time, it indicates that the crystallization amount reaches the standard, the reaction material is moved to the drying box 2 through the material guiding shell 901, the crystallization material is dried, and the crystallization material is obtained,

[0042] In summary, the device can accurately monitor the progress of the crystallization reaction, prevent excessive crystallization reaction, affect the quality of the finished product, and ensure that the reaction is sufficient. In the process of real-time monitoring of the crystallization process, the reaction liquid can flow repeatedly, and the stirring blade 508 moves up and down to realize the full mixing and stirring of the reaction liquid. This method not only prevents the generation of precipitates, but also improves the reaction efficiency. Combined with the stepped temperature regulating assembly 8, the crystallization temperature can be flexibly regulated to provide the most suitable temperature for crystallization, improve the efficiency of the crystallization reaction, and achieve better crystallization effect.

[0043] Finally, it should be noted that: the above only describes the preferred embodiments of the present application and is not intended to limit the present application. Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent replacements to some technical features. Any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. An efficient synthesis device of nicotinamide riboside chloride, comprising a reaction cylinder (1), characterized in that: A lifting and stirring assembly (5) is provided on the reaction cylinder (1), and circulation guide assemblies (4) are provided on both sides of the reaction cylinder (1). Filter detection assemblies (7) are provided on the reaction cylinders (1) on both sides of the lifting and stirring assembly (5). The filter detection assembly (7) includes a filter plate (710) rotatably provided on the inner wall of the reaction cylinder (1), and a filter screen (712) is provided on one side of the bottom end of the filter plate (710). A backwash assembly (6) is provided on the filter detection assembly (7), and the backwash assembly (6) includes a backwash outlet pipe (609) provided on one side below the filter screen (712). A stepped temperature adjustment assembly (8) is provided on the outside of the reaction cylinder (1). A valve assembly (9) is provided at the discharge end of the reaction cylinder (1), and the valve assembly (9) is connected to the filter detection assembly (7). When the filter detection assembly (7) detects that the crystal content reaches the standard, it controls the valve assembly (9) to discharge the material in real time. A drying box (2) is provided at the discharge end of the valve assembly (9).

2. The efficient synthesis device of nicotinamide riboside chloride according to claim 1, characterized in that: The lifting and stirring assembly (5) comprises an electric telescopic rod (502) fixedly arranged on both sides of the top of the reaction barrel (1); the telescopic end of the electric telescopic rod (502) is fixedly connected to a fixed arm (505); both sides of the fixed arm (505) are fixedly connected to a lifting beam (501); the lifting beam (501) is fixedly connected to a stirring motor (506); the output shaft end of the stirring motor (506) is fixedly connected to a stirring column (503); the stirring column (503) extends into the reaction barrel (1) and the bottom side wall is fixedly connected to a stirring blade (508); a driving block (507) is rotatably sleeved on the stirring column (503) above the reaction barrel (1); the driving block (507) is hinged to a linkage rod (504) on both sides; the end of the linkage rod (504) is hinged to a push rod (509); and the push rod (509) is slidably arranged on the top wall of the reaction barrel (1).

3. The efficient synthesis device of nicotinamide riboside chloride according to claim 2, characterized in that: The circulation guide assembly (4) comprises a guide tube (401) arranged on both sides of the reaction tube (1), a feed pipe (405) is arranged between the feed end of the guide tube (401) and the discharge end of the reaction tube (1), a discharge pipe (404) is arranged above the feed pipe (405), one end of the discharge pipe (404) is connected to the discharge end of the guide tube (401), and the other end extends to the top of the reaction tube (1) and passes through the top wall of the reaction tube (1), and is arranged corresponding to the filter plate (710), a piston block (402) is slidably arranged in the guide tube (401), the top of the piston block (402) is fixedly connected to the lifting column (403), and the top of the lifting column (403) is fixedly connected to the lifting beam (501).

4. The efficient synthesis device of nicotinamide riboside chloride according to claim 3, characterized in that: A one-way feed valve is provided at the connection between the feed end of the guide tube (401) and the feed pipe (405), and a one-way discharge valve is provided at the connection between the discharge end of the guide tube (401) and the discharge pipe (404).

5. The efficient synthesis device of nicotinamide riboside chloride according to claim 4, characterized in that: The filtering detection assembly (7) further comprises a lifting rod (701) that slides through the top wall of the reaction cylinder (1); a transmission groove (711) is provided on the side wall of the filter plate (710) on one side of the bottom end of the lifting rod (701); the end of the lifting rod (701) is movably connected to the filter plate (710) through the transmission groove (711); the top of the lifting rod (701) is fixedly connected to the linkage arm (704); a piston column (702) is provided between the linkage arm (704) and the reaction cylinder (1); a compression member (703) is sleeved on the telescopic end of the piston column (702); and the top of the telescopic end of the piston column (702) is fixedly connected to the linkage arm (704).

6. The efficient synthesis device of nicotinamide riboside chloride according to claim 5, characterized in that: The top of the linkage arm (704) is fixedly connected to a stopper (706), a movable column (707) is slidably provided on a push rod (509) on one side of the stopper (706), a reset member (705) is sleeved on the movable column (707), the stopper (706) is fixedly connected to a vertical rod (11) on the reaction tube (1) away from the push rod (509), the vertical rod (11) is fixedly connected to a pneumatic telescopic tube (708), the telescopic end of the pneumatic telescopic tube (708) is arranged corresponding to the movable column (707), and the air outlet end of the pneumatic telescopic tube (708) is connected to the air transmission tube (709).

7. The efficient synthesis device of nicotinamide riboside chloride according to claim 6, characterized in that: The valve assembly (9) includes a material guide shell (901) fixedly arranged at the discharge end of the reaction cylinder (1), the two sides of the material guide shell (901) are fixedly connected to the air transmission cylinder (903), the air inlet end of the air transmission cylinder (903) is connected to the air transmission pipe (709), a push block (902) is slidably arranged in the air transmission cylinder (903), a support member (905) is fixedly connected between the push block (902) and the material guide shell (901), the side wall of the push block (902) is fixedly connected to the valve rod (904), the valve rod (904) is laterally movably arranged on the material guide shell (901), and a valve port (906) is provided on the valve rod (904).

8. The efficient synthesis device of nicotinamide riboside chloride according to claim 7, characterized in that: The recoil assembly (6) further comprises an air guide shell (602) fixedly arranged on the vertical pole (11), the air inlet end of the air guide shell (602) is fixedly connected to the air supply pump (601), a movable groove (608) is provided in the air guide shell (602), a sealing block (607) is slidably arranged in the movable groove (608), the side wall of the sealing block (607) is fixedly connected to the telescopic member (606), one end of the telescopic member (606) is fixedly connected to the movable rod (604), the movable rod (604) extends to the outside of the air guide shell (602), the side wall of the push rod (509) on one side of the movable rod (604) is fixedly connected to the push rod (605), the air outlet end of the air guide shell (602) is connected to the air guide pipe (603), the air guide pipe (603) passes through the side wall of the reaction cylinder (1) and the end thereof is connected to the air inlet end of the recoil outlet pipe (609).

9. The efficient synthesis device of nicotinamide riboside chloride according to claim 8, characterized in that: The stepped temperature regulating assembly (8) comprises a transmission cylinder (801) arranged outside the reaction cylinder (1), the bottom of the transmission cylinder (801) is fixedly connected to the drying box (2), a transmission gear (805) is rotatably arranged in the transmission cylinder (801), a driving rod (802) and a transmission rod (803) are slidably arranged in the transmission cylinder (801) on both sides of the transmission gear (805), and a rack and a transmission gear (803) are arranged on the side of the driving rod (802) and the transmission rod (803) close to the transmission gear (805). 5) engagement, the transmission rod (803) is fixedly connected to the trapezoidal rod (806) on one side away from the driving rod (802), the outer wall of the transmission cylinder (801) on the trapezoidal rod (806) is fixedly connected to the refrigerator (804), and multiple refrigerators (804) are provided. A cooling switch (807) is provided on the inner wall of the transmission cylinder (801) on the side of the refrigerator (804), and the cooling switch (807) corresponds to the trapezoidal rod (806). The output end of the refrigerator (804) is connected to the reaction cylinder (1).

10. The efficient synthesis device of nicotinamide riboside chloride according to claim 1, characterized in that: The drying box (2) is fixedly connected to the dryer (3) on both sides, and a discharge pipe (10) is provided at the discharge end of the drying box (2).

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