Stain-resistant medical antibacterial fabric and preparation process thereof

Abstract

The invention relates to the technical field of antibacterial fabrics, and discloses a stain-resistant medical antibacterial fabric and a preparation process thereof. On the basis that a Schiff base bond is a pH-responsive dynamic chemical bond, when the surface of the fabric is in contact with bacterial infection, a slightly acidic environment generated by metabolism of bacteria enables the antibacterial microspheres A coating the surfaces of the antibacterial microspheres B to be released firstly, and antibiotic gentamicin sulfate loaded by the Schiff base in the antibacterial microspheres A is released, so that the antibacterial effect is achieved; after the bacteria are killed, the contacted slightly acidic environment gradually reaches a neutral equilibrium state, the Schiff base bond is not broken any more, and the antibacterial substance is not released any more, so that a slow release effect is achieved, the service life of the antibacterial property of the fabric is greatly prolonged, and the fabric has the capability of resisting repeated bacterial infection; the problems that a traditional antibacterial fabric is short in service life, cannot resist repeated infection and needs to be replaced repeatedly are solved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of antibacterial fabrics, specifically a stain-resistant medical antibacterial fabric and its preparation process. BACKGROUND

[0002] Medical antibacterial fabrics have important applications in the medical field, used to manufacture medical supplies, nursing products, etc. However, traditional medical antibacterial fabrics are often susceptible to contamination during use, reducing their antibacterial performance and affecting the long-term effectiveness of the products. Current medical antibacterial fabrics have problems such as insufficient stain resistance and unstable antibacterial effect, which pose certain challenges to ensuring the hygiene and safety of the medical environment.

[0003] In view of the problems in the prior art, the present application provides a stain-resistant medical antibacterial fabric and its preparation process, aiming to overcome the limitations of traditional medical antibacterial fabrics. An innovative antibacterial technology and fabric coating can form a durable antibacterial protective layer on the fabric surface, improving stain resistance while maintaining excellent antibacterial performance. It can more effectively prevent the spread of pathogenic microorganisms such as bacteria and viruses, providing more reliable hygiene protection for the medical environment. SUMMARY

[0004] The purpose of the present application is to provide a stain-resistant medical antibacterial fabric and its preparation process to solve the problems raised in the background.

[0005] To solve the above technical problems, the present application provides the following technical solutions: A preparation process for a stain-resistant medical antibacterial fabric, comprising the following steps: S1: Dissolve sodium alginate in deionized water, add sodium periodate, react in the dark for 24-26h, add ethylene glycol to terminate the reaction, dialyze, freeze-dry, and obtain oxidized sodium alginate; Dissolve the oxidized sodium alginate in deionized water, add ethanol and stir until uniform, add gentamicin sulfate, react at room temperature for 4-4.5h, centrifuge, purify, and obtain antibacterial microspheres A; S2: Add antibacterial microspheres A to an ethanol solution, graft antibacterial microspheres B with p-aminobenzoic acid ester, heat-react for 4-4.5h, filter, wash, and obtain antibacterial composite microspheres; S3: Pretreat the fabric; add dopamine hydrochloride to deionized water, adjust the pH to 8.5-9, add the pretreated fabric, stir-react for 24-36h, dry, and obtain a polydopamine fabric; Add the antibacterial composite microspheres to an ethanol solution, add the polydopamine fabric, heat-react for 4-4.5h, wash, dry, and obtain a stain-resistant medical antibacterial fabric.

[0006] Further, the preparation method of the p-aminobenzoic acid ester grafted antibacterial microspheres B in step S2 comprises the following steps: Step (1): swell chitosan in anhydrous ethanol, add vanillin, heat for 15-20 min, add glacial acetic acid, and react for 10-12 h at 50℃, filter, wash, and dry at 60℃ under vacuum to obtain vanillin grafted chitosan; Add zinc acetate ethanol solution to the vanillin grafted chitosan, heat for reaction, filter, wash, and dry at 60℃ under vacuum to obtain chelated zinc grafted chitosan; Step (2): under ice bath condition, dissolve 4-aldehydebenzoic acid in tetrahydrofuran, add N,N-dimethyl-4-aminopyridine and dicyclohexyl carbodiimide, stir until uniform, add borneol, react for 40-45 min under nitrogen condition, continue to react for 3-3.5 h at room temperature, filter, rotary evaporate, column chromatography, and dry under vacuum to obtain 4-aldehydebenzoic acid borneol ester; Step (3): add 4-aldehydebenzoic acid borneol ester and chelated zinc grafted chitosan into dichloromethane, add deionized water and stir until uniform, add ethylene glycol chitosan solution, react at room temperature, remove dichloromethane, filter with 0.22μm sterile microporous filter membrane, and freeze-dry to obtain antibacterial microspheres B; Step (4): add antibacterial microspheres B into isopropyl alcohol pyridine mixture, add p-aminobenzoyl chloride, stir for 3-4 h, adjust pH to neutral, suction filter, and purify to obtain p-aminobenzoic acid ester grafted antibacterial microspheres B.

[0007] Further, the mass ratio of chitosan:vanillin is (0.5-1):(0.85-1.7); the concentration of zinc acetate ethanol solution is 1-1.2g / L, and the heating reaction temperature is 60-65℃.

[0008] Further, the mass ratio of 4-aldehydebenzoic acid:borneol is 0.5:(1-1.2).

[0009] Further, the mass ratio of 4-aldehydebenzoic acid borneol ester:chelated zinc grafted chitosan:dichloromethane:deionized water:ethylene glycol chitosan solution is 2.9:(2-2.18):0.5:(1.5-1.68):0.82; and the concentration of ethylene glycol chitosan solution is 1-1.5wt%.

[0010] Further, the mass ratio of antibacterial microspheres B:p-aminobenzoyl chloride is 1:(1-2).

[0011] Further, the mass ratio of sodium alginate:sodium periodate is 1:(1-1.08); and the mass ratio of oxidized sodium alginate:gentamicin sulfate is 1:(2.7-3).

[0012] Further, the mass ratio of the antibacterial microspheres A: p-aminobenzoate grafted antibacterial microspheres B is (2.15-3.05):(1-1.35).

[0013] Further, the heating reaction temperature in step S2 is 37-40 DEG C.

[0014] Further, the antibacterial composite microspheres are added into an ethanol solution at a ratio of 6-8 mg / mL.

[0015] Further, the fabric pretreatment comprises the following steps: The fabric is cut into a size of 8 cm*8 cm, 2 g / L NaOH solution and 5 g / L H2O2 solution are configured, the bath ratio is 1:50, the cut fabric is put in, heated to 80 DEG C for 60 min, washed with 60 DEG C deionized water, dried, and the pretreated fabric is obtained.

[0016] Compared with the prior art, the present application has the following beneficial effects: The present application selects chitosan with antibacterial performance as a matrix, selects vanillin with antioxidant and antibacterial activity as a natural crosslinking agent, prepares chitosan Schiff base through Schiff base reaction, forms a coordination covalent bond in the chelation process of C=N in chitosan Schiff base and zinc ions; and forms a bidentate ligand with the coordination oxygen atom of -OCH3 on vanillin, and prepares chitosan chelated zinc with a Schiff base structure; then uses chitosan chelated zinc as an antibacterial substance, uses aldehyde group borneol to fix glycol chitosan, and successfully prepares antibacterial microspheres B loaded with chitosan chelated zinc through oil-water emulsion interface Schiff base bonding reaction, in order to ensure that the particle size distribution of the antibacterial microspheres B meets the further Schiff base bonding reaction of the antibacterial microspheres A with smaller particle size, the antibacterial microspheres B need to be filtered through a 0.22 mu m microporous filter after being prepared; finally, the small particle size antibacterial microspheres A loaded with antibiotic gentamicin sulfate are used as a crosslinking agent; the antibacterial microspheres A are reacted with the antibacterial microspheres B and polydopamine fabric in sequence to form a Schiff base bond, the antibacterial microspheres A are successfully coated on the surface of the antibacterial microspheres B, and the antibacterial composite microspheres are prepared; and the antibacterial composite microspheres are successfully modified to the surface of the fabric to form a natural base stain-resistant coating with self-adaptive antibacterial performance, and finally a stain-resistant medical antibacterial fabric is prepared.

[0017] The present application utilizes the fact that the Schiff base bond is a pH-responsive dynamic chemical bond. When the surface of the fabric contacts bacterial infection, the slightly acidic environment produced by bacterial metabolism will cause the antibacterial microspheres B coated with antibacterial microspheres A to release first, and the antibiotics gentamicin sulfate loaded in the antibacterial microspheres A through the Schiff base will be released, achieving the effect of inhibiting bacteria. When the bacteria are killed, the slightly acidic environment gradually reaches a neutral balance state, the Schiff base bond no longer breaks, and the antibacterial substance no longer releases, having a slow-release effect, greatly improving the service life of the fabric antibacterial performance and the ability to resist repeated bacterial infection. The problem of short service life of traditional antibacterial fabric, inability to resist repeated infection, and the need for repeated replacement is solved. Because the cross-linking component sodium alginate in the antibacterial microspheres A contains a large number of hydroxyl groups, the surface of the fabric has good hydrophilic properties, the surface energy of the fabric is reduced, and the non-specific adsorption of bacteria on the surface is effectively prevented, greatly improving the stain resistance of the fabric. When the hydrophilicity of the fabric surface is lower than before, it means that the antibacterial fabric needs to be replaced. The reason is that when the aldehyde group of the hydrophobic camphor fat and the chitosan chelated zinc are used as the last antibacterial component, the release of the antibacterial microspheres B will reduce the hydrophilicity of the fabric surface, reminding medical staff that the antibacterial performance of the fabric has been greatly reduced and should not be used continuously.

[0018] The prepared pollution type medical antibacterial fabric not only has antibacterial and stain resistance, but also has a high service life, solving the problem of frequent replacement during medical treatment, greatly reducing the probability of repeated infection, and reducing the waste of medical resources. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present application will be described below. Obviously, the described embodiments are only a part of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0020] In the following examples, the fabric is a polyester / spandex knitted fabric, the fabric area density is 200 g / m 2 , the polyester content is 71%, the spandex content is 29%, and it is purchased from Fu Ying Textile Co., Ltd.; sodium alginate is purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.; gentamicin sulfate is purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.; chitosan is purchased from Macklin (Shanghai) Biochemical Technology Co., Ltd., DD=90%; ethylene glycol chitosan is purchased from Wako Pure Chemical Industries, Ltd., Mw=82000; and the rest of the raw materials are commercially available.

[0021] The fabric pretreatment includes the following steps: The fabric is cut into 8cm x 8cm size, 2g / L NaOH solution and 5g / L H2O2 solution are configured, the bath ratio is 1:50, the cut fabric is put in, heated to 80℃ for 60min, washed with 60℃ deionized water, dried, and the pretreated fabric is obtained.

[0022] Example 1: Preparation process of a stain-resistant medical antibacterial fabric: S1: 1g of sodium alginate is dissolved in deionized water, 1.08g of sodium periodate is added, and the reaction is carried out in the dark for 24h, then the reaction is terminated by adding ethylene glycol, dialysis is performed, and freeze-drying is performed to obtain oxidized sodium alginate; S2: 1g of oxidized sodium alginate is dissolved in deionized water, ethanol is added and stirred uniformly, 2.7g of gentamicin sulfate is added, and the reaction is carried out at room temperature for 4h, then centrifugation is performed, and purification is performed to obtain antibacterial microspheres A; S3: 0.5g of chitosan is swelled in anhydrous ethanol, 0.85g of vanillin is added, and the reaction is carried out at 60℃ for 15min, then glacial acetic acid is added, and the reaction is carried out at 50℃ for 10h, then rotary evaporation is performed at 50℃, filtration is performed, washing is performed, and vacuum drying is performed at 60℃ to obtain vanillin grafted chitosan; S4: 1g / L zinc acetate ethanol solution is added to the vanillin grafted chitosan, the reaction is carried out at 60℃, filtration is performed, washing is performed, and vacuum drying is performed at 60℃ for 24h to obtain grafted chitosan chelated zinc; S5: 0.5g of 4-aldehyde benzoic acid is dissolved in 30mL of tetrahydrofuran under ice bath conditions, 0.1N,N-dimethyl-4-aminopyridine and 1.7 dicyclohexyl carbodiimide are added and stirred uniformly, 1g of borneol is added, the reaction is carried out under nitrogen for 40min, and the reaction is carried out at room temperature for 3h, then filtration is performed, rotary evaporation is performed, column chromatography is performed, and vacuum drying is performed to obtain 4-aldehyde benzoic acid borneol ester; S6: 2.9g of 4-aldehyde benzoic acid borneol ester and 2g of grafted chitosan chelated zinc are added to 0.5g of dichloromethane, 1.5g of deionized water is added and stirred uniformly, 0.82g of 1wt% ethylene glycol chitosan solution is added, the reaction is carried out at room temperature, dichloromethane is removed, filtration is performed, and freeze-drying is performed to obtain antibacterial microspheres B; S7: 1g of antibacterial microspheres B is added to an isopropyl alcohol pyridine mixture, 1.5g of p-aminobenzoyl chloride is added, and the reaction is carried out for 3h, then the pH is adjusted to neutral, suction filtration is performed, and purification is performed to obtain p-aminobenzoate grafted antibacterial microspheres B; S8: 2.15g of antibacterial microspheres A is added to an ethanol solution, 1g of p-aminobenzoate grafted antibacterial microspheres B is added, the reaction is carried out at 37℃ for 4h, filtration is performed, and washing is performed to obtain antibacterial composite microspheres; S9: The fabric is pretreated; dopamine hydrochloride is added to deionized water, the pH is adjusted to 8.5, the pretreated fabric is added, the reaction is carried out for 24h, and the fabric is dried to obtain a polydopamine fabric; S10: 6 mg / mL antibacterial composite microspheres were added to an ethanol solution, polydopamine fabric was added, and the reaction was heated at 37°C for 4 h, washed, and dried to obtain a stain-resistant medical antibacterial fabric.

[0023] Example 2: Preparation process of a stain-resistant medical antibacterial fabric: S1: 1 g of sodium alginate was dissolved in deionized water, 1.08 g of sodium periodate was added, and the reaction was carried out in the dark for 24 h. Ethylene glycol was added to terminate the reaction, dialysis was performed, and freeze-drying was performed to obtain oxidized sodium alginate; S2: 1 g of oxidized sodium alginate was dissolved in deionized water, ethanol was added and stirred until uniform, 3 g of gentamicin sulfate was added, and the reaction was carried out at room temperature for 4 h. Centrifugation was performed, and purification was performed to obtain antibacterial microspheres A; S3: 0.5 g of chitosan was swelled in anhydrous ethanol, 0.85 g of vanillin was added, and the reaction was heated at 60°C for 15 min. Glacial acetic acid was added, and the reaction was carried out at 50°C for 10 h. Filtration was performed, washing was performed, and vacuum drying was performed at 60°C to obtain vanillin grafted chitosan; S4: 1 g / L zinc acetate ethanol solution was added to the vanillin grafted chitosan, the reaction was heated at 60°C, filtration was performed, washing was performed, and vacuum drying was performed at 60°C for 24 h to obtain grafted chitosan chelated zinc; S5: 0.5 g of 4-aldehyde benzoic acid was dissolved in 30 mL of tetrahydrofuran under ice bath conditions, 0.1 N,N-dimethyl-4-aminopyridine and 1.7 dicyclohexyl carbodiimide were added and stirred until uniform, 1 g of borneol was added, and the reaction was carried out under nitrogen for 40 min. The reaction was continued at room temperature for 3 h, filtration was performed, rotary evaporation was performed, column chromatography was performed, and vacuum drying was performed to obtain 4-aldehyde benzoic acid borneol ester; S6: 2.9 g of 4-aldehyde benzoic acid borneol ester and 2 g of grafted chitosan chelated zinc were added to 0.5 g of dichloromethane, 1.5 g of deionized water was added and stirred until uniform, 0.82 g of 1 wt% ethylene glycol chitosan solution was added, and the reaction was carried out at room temperature. Dichloromethane was removed, filtration was performed, and freeze-drying was performed to obtain antibacterial microspheres B; S7: 1 g of antibacterial microspheres B was added to an isopropyl alcohol pyridine mixture, 1.5 g of p-aminobenzoyl chloride was added, and the reaction was stirred for 3 h. The pH was adjusted to neutral, suction filtration was performed, and purification was performed to obtain p-aminobenzoate grafted antibacterial microspheres B; S8: 2.15 g of antibacterial microspheres A was added to an ethanol solution, 1 g of p-aminobenzoate grafted antibacterial microspheres B was added, and the reaction was heated at 37°C for 4 h. Filtration was performed, and washing was performed to obtain antibacterial composite microspheres; S9: The fabric was pretreated; dopamine hydrochloride was added to deionized water, the pH was adjusted to 8.5, the pretreated fabric was added, and the reaction was stirred for 24 h. Drying was performed to obtain a polydopamine fabric; S10: 6 mg / mL antibacterial composite microspheres were added to an ethanol solution, polydopamine fabric was added, and the reaction was heated at 37°C for 4 h, washed, and dried to obtain a stain-resistant medical antibacterial fabric.

[0024] Example 3: Preparation process of a stain-resistant medical antibacterial fabric: S1: 1 g of sodium alginate was dissolved in deionized water, 1.08 g of sodium periodate was added, and the reaction was carried out in the dark for 24 h. Ethylene glycol was added to terminate the reaction, dialysis was performed, and freeze-drying was performed to obtain oxidized sodium alginate; S2: 1 g of oxidized sodium alginate was dissolved in deionized water, ethanol was added and stirred until uniform, 2.7 g of gentamicin sulfate was added, and the reaction was carried out at room temperature for 4 h. Centrifugation was performed, and purification was performed to obtain antibacterial microspheres A; S3: 1 g of chitosan was swelled in anhydrous ethanol, 1.7 g of vanillin was added, the reaction was carried out at 60°C for 15 min, glacial acetic acid was added, the reaction was carried out at 60°C for 10 h, rotary evaporation was performed at 50°C, filtration was performed, washing was performed, and vacuum drying was performed at 60°C to obtain vanillin grafted chitosan; S4: 1 g / L zinc acetate ethanol solution was added to the vanillin grafted chitosan, the reaction was carried out at 60°C, filtration was performed, washing was performed, and vacuum drying was performed at 60°C for 24 h to obtain grafted chitosan chelated zinc; S5: 0.5 g of 4-aldehyde benzoic acid was dissolved in 30 mL of tetrahydrofuran under ice bath conditions, 0.1 N,N-dimethyl-4-aminopyridine and 1.7 dicyclohexyl carbodiimide were added and stirred until uniform, 1 g of borneol was added, the reaction was carried out under nitrogen for 40 min, the reaction was continued at room temperature for 3 h, filtration was performed, rotary evaporation was performed, column chromatography was performed, and vacuum drying was performed to obtain 4-aldehyde benzoic acid borneol ester; S6: 2.9 g of 4-aldehyde benzoic acid borneol ester and 2 g of grafted chitosan chelated zinc were added to 0.5 g of dichloromethane, 1.5 g of deionized water was added and stirred until uniform, 0.82 g of 1 wt% ethylene glycol chitosan solution was added, the reaction was carried out at room temperature, dichloromethane was removed, filtration was performed, and freeze-drying was performed to obtain antibacterial microspheres B; S7: 1 g of antibacterial microspheres B was added to an isopropyl alcohol pyridine mixture, 1.5 g of p-aminobenzoyl chloride was added, stirring was carried out for 3 h, the pH was adjusted to neutral, suction filtration was performed, and purification was performed to obtain p-aminobenzoate grafted antibacterial microspheres B; S8: 2.15 g of antibacterial microspheres A was added to an ethanol solution, 1 g of p-aminobenzoate grafted antibacterial microspheres B was added, the reaction was carried out at 37°C for 4 h, filtration was performed, and washing was performed to obtain antibacterial composite microspheres; S9: The fabric was pretreated; dopamine hydrochloride was added to deionized water, the pH was adjusted to 8.5, the pretreated fabric was added, stirring was carried out for 24 h, and drying was performed to obtain a polydopamine fabric; S10: 6 mg / mL antibacterial composite microspheres were added to an ethanol solution, polydopamine fabric was added, the reaction was heated at 37°C for 4 h, washing was performed, and drying was performed to obtain a stain-resistant medical antibacterial fabric.

[0025] Example 4: Preparation process of a stain-resistant medical antibacterial fabric: S8: 3.05 g of antibacterial microspheres A was added to an ethanol solution, 1.35 g of p-aminobenzoate grafted antibacterial microspheres B was added, heated at 37°C for 4 h, filtered, washed, and antibacterial composite microspheres were obtained; The remaining steps are the same as example 1.

[0026] Example 5: Preparation process of a stain-resistant medical antibacterial fabric: S10: 7 mg / mL of antibacterial composite microspheres was added to an ethanol solution, polydopamine fabric was added, heated at 37°C for 4 h, washed, dried, and a stain-resistant medical antibacterial fabric was obtained.

[0027] The remaining steps are the same as example 1.

[0028] Example 6: Preparation process of a stain-resistant medical antibacterial fabric: S10: 8 mg / mL of antibacterial composite microspheres was added to an ethanol solution, polydopamine fabric was added, heated at 37°C for 4 h, washed, dried, and a stain-resistant medical antibacterial fabric was obtained.

[0029] The remaining steps are the same as example 1.

[0030] Comparative example 1: Preparation process of a stain-resistant medical antibacterial fabric: S1: polydopamine fabric was added to a 6 mg / mL sodium alginate oxidized solution and reacted for 12 h, after washing, 6 mg / mL of gentamicin sulfate solution was added and reacted for 12 h, washed, dried, and a stain-resistant medical antibacterial fabric was obtained.

[0031] Comparative example 2: Preparation process of a stain-resistant medical antibacterial fabric: S8: 1.05 g of antibacterial microspheres A was added to an ethanol solution, 1.35 g of p-aminobenzoate grafted antibacterial microspheres B was added, heated at 37°C for 4 h, filtered, washed, and antibacterial composite microspheres were obtained; The remaining steps are the same as example 1.

[0032] Comparative example 3: Preparation process of a stain-resistant medical antibacterial fabric: S10: 4 mg / mL of antibacterial composite microspheres was added to an ethanol solution, polydopamine fabric was added, heated at 37°C for 4 h, washed, dried, and a stain-resistant medical antibacterial fabric was obtained.

[0033] The remaining steps are the same as example 1.

[0034] Test: antibacterial performance test: 4 μL of Staphylococcus aureus was added to 4 mL of LB culture solution, incubated at 37°C for 24 h, and the bacterial density was determined; the bacterial suspension concentration was diluted to 10 5CFU / mL, the stain-resistant medical antibacterial fabric was added into a 48-well plate, 200 μL of the diluted bacterial solution was added into each well, 37°C incubation was performed for 12h, after the incubation was completed, 100 μL of the bacterial suspension was removed from each well to a new 96-well plate, the absorbance at OD600nm was measured by using an enzyme-labeled instrument, and the antibacterial rate was calculated, and the operation was repeated 4 times.

[0035] Antibacterial stability test: The long-term antibacterial stability of the stain-resistant medical antibacterial fabric was tested by using the inhibition zone. The stain-resistant medical antibacterial fabric was soaked in PBS buffer for 5 months. Staphylococcus aureus was diluted to 10 5 CFU / mL, and then 50 μL of the bacterial suspension was uniformly smeared on a standard culture plate, the fabric soaked for 5 months was placed in the center of the culture plate, and 37°C incubation was performed for 24h, and then whether the inhibition zone appeared was observed.

[0036] Stain resistance test: The stain-resistant medical antibacterial fabric was placed in a 48-well plate, 500 μL of the bovine serum albumin solution was added into each well, and then the fabric surface was adhered to the protein by ultrasonic washing, and the anti-protein adsorption performance was determined, and the blank fabric was used as the reference, and the protein adsorption rate was 100%.

[0037] Table 1: antibacterial performance test data

[0038] Table 2: antibacterial stability test data

[0039] Table 3: stain resistance test data

[0040] Conclusion: The stain-resistant medical antibacterial fabric prepared in the application has antibacterial, stain-resistant performance, and high service life. The comparative example 1 lacks microsphere slow release, and when encountering a slightly acidic environment, it is almost completely released, resulting in reduced antibacterial repeat performance; the surface loading amount of antibacterial microspheres A in the comparative example 2 is reduced, the amount of antibacterial composite microspheres on the surface of the fabric in the comparative example 3 is reduced, resulting in reduced antibacterial repeat performance.

[0041] Finally, it should be noted that: the above only describes the preferred embodiments of the application, and is not used to limit the application, although the application has been described in detail with reference to the foregoing embodiments, and for those skilled in the art, the technical solutions recorded in the foregoing embodiments can still be modified, or some technical features can be replaced. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the application shall be included in the protection scope of the application.

Claims

1. A process for preparing a stain-resistant medical antibacterial fabric, characterized by: The following steps are involved: S1: Sodium alginate was dissolved in deionized water, sodium periodate was added, and the mixture was allowed to react in the dark for 24-26 hours. Ethylene glycol was added to terminate the reaction, and the mixture was dialyzed and freeze-dried to obtain oxidized sodium alginate. Dissolve oxidized sodium alginate in deionized water, add ethanol and stir evenly, add gentamicin sulfate, react at room temperature for 4-4.5 hours, centrifuge, and purify to obtain antibacterial microspheres A; S2: adding antibacterial microspheres A to an ethanol solution, adding para-aminobenzoate-grafted antibacterial microspheres B, heating to react for 4-4.5 hours, filtering, and washing to obtain antibacterial composite microspheres; S3: pretreating the fabric; adding dopamine hydrochloride to deionized water, adjusting the pH to 8.5-9, adding the pretreated fabric, stirring and reacting for 24-36 hours, and drying to obtain a polydopamine fabric; The antibacterial composite microspheres are added to an ethanol solution, and then polydopamine fabric is added. The mixture is heated to react for 4-4.5 hours, washed, and dried to obtain a stain-resistant medical antibacterial fabric.

2. The process for preparing a stain-resistant medical antibacterial fabric according to claim 1, characterized in that: The method for preparing the p-aminobenzoate grafted antibacterial microspheres B in step S2 comprises the following steps: Step (1): dissolve chitosan in anhydrous ethanol, add vanillin, heat to react for 15-20 minutes, add glacial acetic acid, keep warm to react for 10-12 hours, evaporate at 50°C, filter, wash, and vacuum dry at 60°C to obtain vanillin-grafted chitosan; Add zinc acetate ethanol solution to vanillin grafted chitosan, heat to react, filter, wash, and vacuum dry at 60°C to obtain grafted chitosan chelated zinc; Step (2): Under ice bath conditions, dissolve 4-formylbenzoic acid in tetrahydrofuran, add N,N-dimethyl-4-aminopyridine and dicyclohexylcarbodiimide and stir evenly, add borneol, react under nitrogen conditions for 40-45 minutes, continue to react at room temperature for 3-3.5 hours, filter, rotary evaporate, column chromatography, and vacuum dry to obtain 4-formylbenzoic acid borneol ester; Step (3): Add 4-formylbenzoate bornyl ester and grafted chitosan chelated zinc into dichloromethane, add deionized water and stir evenly, add ethylene glycol chitosan solution, react at room temperature, remove dichloromethane, filter, and freeze-dry to obtain antibacterial microspheres B; Step (4): Add the antibacterial microspheres B to the isopropyl alcohol-pyridine mixture, add p-aminobenzoyl chloride, stir and react for 3-4 hours, adjust the pH to neutral, filter and purify to obtain p-aminobenzoate grafted antibacterial microspheres B.

3. The preparation process of a stain-resistant medical antibacterial fabric according to claim 2, characterized in that: In step (1), the mass ratio of chitosan to vanillin is (0.5-1):(0.85-1.7); the concentration of the zinc acetate ethanol solution is 1-1.2 g / L, and the heating reaction temperature is 60-65°C.

4. The process for preparing a stain-resistant medical antibacterial fabric according to claim 2, characterized in that: In step (2), the mass ratio of 4-formylbenzoic acid to borneol is 0.5:(1-1.2).

5. The process for preparing a stain-resistant medical antibacterial fabric according to claim 2, characterized in that: In step (3), the mass ratio of the 4-formylbenzoic acid bornyl ester: grafted chitosan chelated zinc: dichloromethane: deionized water: ethylene glycol chitosan solution is 2.9: (2-2.18): 0.5: (1.5-1.68): 0.82; the concentration of the ethylene glycol chitosan solution is 1-1.5 wt%.

6. The process for preparing a stain-resistant medical antibacterial fabric according to claim 2, characterized in that: In step (4), the mass ratio of the antibacterial microspheres B to p-aminobenzoyl chloride is 1:(1-2).

7. The process for preparing a stain-resistant medical antibacterial fabric according to claim 1, characterized in that: In step S1, the mass ratio of the sodium alginate:sodium periodate is 1:(1-1.08); the mass ratio of the oxidized sodium alginate:gentamicin sulfate is 1:(2.7-3).

8. The process for preparing a stain-resistant medical antibacterial fabric according to claim 1, characterized in that: In step S2, the mass ratio of the antibacterial microspheres A to the para-aminobenzoate grafted antibacterial microspheres B is (2.15-3.05):(1-1.35); and the heating reaction temperature is 37-40°C.

9. The process for preparing a stain-resistant medical antibacterial fabric according to claim 1, characterized in that: In step S3, the antibacterial composite microspheres are added to the ethanol solution at a ratio of 6-8 mg / mL.

10. The stain-resistant medical antibacterial fabric prepared according to the preparation process of the stain-resistant medical antibacterial fabric according to any one of claims 1 to 9.

Images