Liquid dispensing device and detection system

Abstract

The invention provides a liquid dispensing device and a detection system. The liquid distribution device comprises a push rod and a barrel, the push rod comprises a near-end operation part, a far-end sealing part and a deformable part extending between the near-end operation part and the far-end sealing part, and a buckle protruding in the radial direction of the push rod is arranged on the peripheral wall of the deformable part; the inner wall of the barrel and the far-end sealing part can be matched in a sealing mode and can move relatively, a push rod inlet is formed in one end of the barrel, a liquid outlet is formed in the other end of the barrel, a sliding groove is formed in the push rod inlet, and a circumferential rotating groove of the sliding groove is recessed from the inner wall of the barrel in the axis direction away from the barrel. The slope groove of the sliding groove is connected with the circumferential rotating groove, inclines towards the interior of the barrel and extends towards the liquid outlet, the circumferential rotating groove is provided with an inlet end communicated with the push rod inlet, and the circumferential rotating groove is arranged to be in rotating fit with the circumferential rotating groove when the push rod is pushed to enable the buckle to stretch into the circumferential rotating groove from the inlet end; the slope groove is arranged to be in extrusion fit with the buckle when the buckle passes through the slope groove so as to push the buckle and the push rod downwards.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of liquid dispensing and conveying, and in particular, the present application relates to a liquid dispensing device and a detection system. BACKGROUND

[0002] At present, in the fields of laboratory detection, medical and health care, biological pharmaceuticals, chemical production and food processing, it is often necessary to accurately control the dispensing amount of liquid to ensure the accuracy of experimental results or the consistency of product quality. Traditional liquid dispensing tools mainly use plunger syringes or various pump devices to realize the supply or conveying of liquid, but they have certain deficiencies in actual application. For example, conventional syringes mainly rely on manual direct pushing of the plunger device of the syringe, and it is difficult to accurately control the position and depth of pushing, which can easily cause dosage errors, especially in micro-liquid dispensing tasks. For another example, some high-precision dispensing pump devices on the market have certain accurate conveying capacity, but they are often complex in structure, high in manufacturing cost, and cumbersome to use and maintain, and cannot be widely used in some cost-sensitive fields or daily experimental operations.

[0003] Therefore, it is necessary to develop a simple and easy-to-use liquid dispensing device with reasonable cost and convenient accurate quantitative control.

[0004] DISCLOSURE

[0005] In a first aspect of the present application, a liquid dispensing device is provided, comprising:

[0006] a push rod, the push rod comprising a proximal end operation part, a distal end sealing part, and a deformable part extending between the proximal end operation part and the distal end sealing part, the outer peripheral wall of the deformable part having a buckle, the buckle being radially protruding along the push rod; and

[0007] a barrel, the inner wall of the barrel being sealably cooperable with the distal end sealing part and being relatively movable, one end of the barrel being provided with a push rod inlet, the other end of the barrel being provided with a liquid outlet, the push rod inlet being provided with a sliding groove, the sliding groove comprising a circumferential rotation groove and an inclined groove, the circumferential rotation groove being recessed from the inner wall of the barrel in a direction away from the axis of the barrel, the inclined groove being connected with the circumferential rotation groove and being inclined inwardly toward the barrel and extending in the direction of the liquid outlet, the circumferential rotation groove being provided with an inlet end, the inlet end being in communication with the push rod inlet, the circumferential rotation groove being arranged to be rotationally cooperated with the circumferential rotation groove when the buckle is pushed into the circumferential rotation groove from the inlet end, the inclined groove being arranged to be extrusionally cooperated with the buckle to push the buckle and the push rod downwardly when the buckle passes through the inclined groove.

[0008] The liquid dispensing device of the present application has at least the following technical effects: the buckle on the deformable part can be matched with the sliding groove to realize quantitative liquid dispensing, for example, the depth of the push rod pushed into the cylinder can be regulated by the buckle, the buckle can be prevented from being popped up under the action of air pressure by the circumferential rotating groove, thereby facilitating accurate control of the travel distance and stop position of the push rod when the cylinder discharges liquid, and improving the accuracy of quantitative liquid dispensing. Compared with the existing manual liquid pushing, the operation is simple, and it is beneficial to quickly, efficiently and accurately complete the quantitative dispensing of liquid, improve the stability of repeated operation (such as using multiple liquid dispensing devices of the same specification to perform the same operation) or operation by different personnel, and facilitate the performance of parallel test or control test.

[0009] In some embodiments of the present application, the deformable part comprises a deformable beam extending along the length direction of the push rod, and the buckle is arranged on the outer peripheral wall of the deformable beam.

[0010] In some embodiments of the present application, the distance between the outer peripheral wall of the deformable beam and the push rod axis is less than or equal to the distance between the outer peripheral wall of the distal end sealing part and the push rod axis; and the distance between the outer peripheral wall of the buckle and the push rod axis is greater than the distance between the outer peripheral wall of the distal end sealing part and the push rod axis.

[0011] In some embodiments of the present application, the deformable part comprises a plurality of deformable beams arranged circumferentially at intervals along the push rod, and each deformable beam is independently provided with at least one buckle.

[0012] In some embodiments of the present application, the push rod comprises one or more layers of buckles, the plurality of layers of buckles are arranged at intervals along the length direction of the push rod, the number of buckles in each layer is one or more, the plurality of buckles in the same layer are arranged at intervals along the circumference of the push rod, and the distance between the buckles in the same layer and the distal end sealing part in the length direction of the push rod is equal.

[0013] In some embodiments of the present application, the push rod comprises a plurality of layers of buckles, the number of buckles in each layer is a plurality, the number of buckles in different layers is the same, and the corresponding arc of the adjacent two buckles on one of the two adjacent layers is the same as the corresponding arc of the adjacent two buckles on the other layer.

[0014] In some embodiments of the present application, the deformable beam comprises a cantilever beam, and the buckle on the cantilever beam is arranged at the free end of the cantilever beam.

[0015] In some embodiments of the present application, the deformable beam comprises a double-end fixed beam, and the buckle is arranged between two ends of the double-end fixed beam.

[0016] In some embodiments of the present application, the double-end fixed beam is provided with a fracture near one side of the distal sealing portion.

[0017] In some embodiments of the present application, the liquid outlet is provided with a sample enrichment layer and / or a sealing layer.

[0018] In a second aspect of the present application, a detection system is provided, comprising the liquid dispensing device provided in the first aspect of the present application.

[0019] As non-limiting examples, the present application provides the following embodiments:

[0020] 1. A liquid dispensing device, comprising:

[0021] a push rod comprising a proximal operating portion, a distal sealing portion, and a deformable portion extending between the proximal operating portion and the distal sealing portion, an outer peripheral wall of the deformable portion having a buckle protruding radially along the push rod; and

[0022] a barrel having an inner wall sealably and movably cooperating with the distal sealing portion, one end of the barrel being provided with a push rod inlet, the other end of the barrel being provided with a liquid outlet, the push rod inlet being provided with a sliding groove, the sliding groove comprising a circumferential rotation groove and an inclined groove, the circumferential rotation groove being recessed from the inner wall of the barrel in a direction away from an axis of the barrel, the inclined groove being connected with the circumferential rotation groove and being inclined inwardly toward the barrel and extending toward the liquid outlet, the circumferential rotation groove being provided with an inlet end, the inlet end being in communication with the push rod inlet, the circumferential rotation groove being configured to rotate with the buckle when the buckle is extended into the circumferential rotation groove from the inlet end by pushing the push rod; the inclined groove being configured to press the buckle to push the buckle and the push rod downwardly when the buckle passes through the inclined groove.

[0023] 2. The liquid dispensing device of embodiment 1, wherein the deformable portion comprises a deformable beam extending along a length direction of the push rod, and the buckle is arranged on an outer peripheral wall of the deformable beam.

[0024] 3. The liquid dispensing device of embodiment 2, wherein a distance between the outer peripheral wall of the deformable beam and the axis of the push rod is less than or equal to a distance between the outer peripheral wall of the distal sealing portion and the axis of the push rod; and a distance between the outer peripheral wall of the buckle and the axis of the push rod is greater than the distance between the outer peripheral wall of the distal sealing portion and the axis of the push rod.

[0025] 4. The liquid dispensing device of any one of embodiments 1-3, wherein the deformable portion comprises one or more snaps, and the plurality of snaps are spaced apart along a circumferential direction and / or a length direction of the push rod.

[0026] 5. The liquid dispensing device of any one of embodiments 1-4, wherein the deformable portion comprises a plurality of deformable beams spaced apart along a circumferential direction of the push rod, and each of the deformable beams is independently provided with at least one snap.

[0027] 6. The liquid dispensing device of any one of embodiments 1-5, wherein the push rod comprises one or more layers of snaps, and the number of snaps in each layer is one or more, the plurality of snaps in the same layer are spaced apart along a circumferential direction of the push rod, and the distance between the snaps in the same layer and the distal sealing portion along a length direction of the push rod is equal.

[0028] 7. The liquid dispensing device of any one of embodiments 1-6, wherein the push rod comprises a plurality of layers of snaps, the number of snaps in each layer is a plurality, the number of snaps in different layers is the same, and the corresponding arc of the adjacent two snaps in one of the layers is the same as the corresponding arc of the adjacent two snaps in the other layer.

[0029] 8. The liquid dispensing device of embodiment 7, wherein the number of snaps in each layer is two.

[0030] 9. The liquid dispensing device of embodiment 7 or 8, wherein the corresponding arc of the adjacent two snaps in the same layer is 100°-180°.

[0031] 10. The liquid dispensing device of any one of embodiments 1-9, wherein the distance between the outer circumferential wall of the inlet end and the axis of the barrel is greater than or equal to the distance between the outer circumferential wall of the circumferential rotation groove and the axis of the barrel; and / or,

[0032] the distance from the connection between the side of the beveled groove close to the inlet of the push rod and the barrel to the axis of the barrel gradually decreases in a direction away from the circumferential rotation groove; and / or,

[0033] the distance from the connection between the side of the beveled groove close to the liquid outlet and the barrel to the axis of the barrel is the same as the distance from the inner wall of the barrel to the axis of the barrel; and / or,

[0034] The groove height of the circumferential rotation groove is 0.02mm-1mm larger than the extension distance of the buckle along the length direction of the push rod; and / or,

[0035] The inclined groove is arranged on the side of the circumferential rotation groove extending along the inner wall of the cylinder in the circumferential direction, or the side of the circumferential rotation groove facing the inside of the cylinder, or the side of the circumferential rotation groove facing the inside of the cylinder and close to the liquid outlet and away from the circumferential rotation groove in the circumferential direction of the cylinder.

[0036] 11. The liquid dispensing device of any one of embodiments 1-10, wherein the buckle is a deformable buckle.

[0037] 12. The liquid dispensing device of any one of embodiments 2-11, wherein the deformable beam comprises a cantilever beam, and the buckle on the cantilever beam is arranged at the free end of the cantilever beam; and / or,

[0038] The deformable beam comprises a double-end fixed beam, and the buckle on the double-end fixed beam is arranged between the two ends of the double-end fixed beam.

[0039] 13. The liquid dispensing device of any one of embodiments 2-12, wherein the deformable beam comprises a double-end fixed beam, and the double-end fixed beam is provided with a fracture close to one side of the distal end sealing part.

[0040] 14. The liquid dispensing device of any one of embodiments 1-13, wherein the distal end sealing part is an elastic distal end sealing part; and / or,

[0041] The distal end sealing part comprises a sealing ring and / or a piston.

[0042] 15. The liquid dispensing device of any one of embodiments 1-14, wherein the liquid outlet is provided with a sample enrichment layer and / or a sealing layer.

[0043] 16. The liquid dispensing device of any one of embodiments 1-15, wherein the proximal end operating part is provided with a pressing part on the side away from the distal end sealing part.

[0044] 17. The liquid dispensing device of embodiment 16, wherein the distance from the outer peripheral wall of the pressing part to the push rod axis is greater than the distance from the outer peripheral wall of the deformable part to the push rod axis.

[0045] 18. A detection system comprising the liquid dispensing device of any one of embodiments 1-17.

[0046] 19. The detection system as described in embodiment 18, wherein it includes a detection unit, and the sample inlet of the detection unit is arranged in coordination with the liquid outlet of the liquid dispensing device.

[0047] 20. The detection system of embodiment 18 or 19, wherein the detection unit comprises one or more of a test strip, an electrochemical detection device, and an optical detection device. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 This is a schematic structural diagram of a liquid dispensing device in one embodiment of the present application, wherein Figure 1 In the figure a is a schematic diagram of the structure in which the push rod is inserted into the cylinder, and in the figure b is a schematic diagram of the structure in which the push rod is not inserted into the cylinder.

[0049] Figure 2 This is a schematic diagram of the structure of the cylinder and the chute in one embodiment of the present application, wherein Figure 2 In the figure a is a schematic diagram of the structure of the cylinder, and b is an enlarged diagram of the structure of a local area of ​​the cylinder shown in a.

[0050] Figure 3 This is a structural diagram of the matching relationship between the push rod with a buckle and the slide groove in the liquid distribution device in one embodiment of the present application, wherein Figure 3 b is a schematic diagram of the structure of the push rod inserted into the cylinder, and a is an enlarged view of the local area G in b.

[0051] Figure 4 Schematic diagram of the structure of a push rod in one embodiment of the present application.

[0052] Figure 5 for Figure 4 Schematic diagram of the structure rotated 90° clockwise along the push rod axis.

[0053] Figure 6 This is a schematic structural diagram of a push rod in another embodiment of the present application.

[0054] Figure 7 This is a schematic structural diagram of a push rod in another embodiment of the present application. Figure 7 In the figure, a, b, and c are schematic diagrams of the structure of the push rod from three different perspectives, b is a schematic diagram of the push rod in a rotated 90° clockwise along the direction of the black arrow, and c is a side view of a.

[0055] Figure 8 This is a schematic structural diagram of a push rod in another embodiment of the present application. Figure 7 In the figure, a, b, and c are schematic diagrams of the structure of the push rod from three different perspectives, b is a schematic diagram of a rotated 90° clockwise along the axis of the push rod, and c is a side view of a.

[0056] Figure 9A schematic diagram of the structure of the push rod with a fracture in an embodiment of the present application.

[0057] Figure 10 A schematic diagram of the deformable beam of the push rod in an embodiment of the present application after use and irreversible deformation at the fracture.

[0058] Figure 11 A step-by-step motion disassembly diagram of the push rod and the barrel cooperation with two layers of buckles in an embodiment of the present application, in which the black arrow represents the movement mode of the push rod.

[0059] BRIEF DESCRIPTION OF DRAWINGS

[0060] 10-push rod; 11-deformable part; 11a-buckle; 11a1-first layer of buckle; 11a2-second layer of buckle; 11b-deformable beam; 12-distal sealing part; 13-proximal operating part; 13a-pressing part; 14-fracture; 20-barrel; 21-push rod inlet; 22-sliding groove; 22a-circumferential rotation groove; 22b-inclined groove; 22c-inlet end of the sliding groove; 23-liquid outlet; 24-sample enrichment layer. DETAILED DESCRIPTION

[0061] The present application will be further described below in connection with specific embodiments. It should be understood that these embodiments are intended to illustrate the present application and not to limit the scope of the present application.

[0062] In the present application, the following definitions and methods are provided to better define the present application and to guide those of ordinary skill in the art in the practice of the present application. Unless otherwise indicated, the terms are to be understood according to conventional usage by those of ordinary skill in the relevant art.

[0063] As used herein, the term "comprising" is to be construed as non-exhaustive and open-ended, rather than exclusive. Specifically, when used in the specification and in the claims, the term "comprising" and variations thereof mean the inclusion of the recited elements, steps, or components but not to the exclusion of others.

[0064] As used herein, the term "optional" means that the subsequently described event or circumstance can or can not occur, and that the description includes situations where the event or circumstance occurs and situations where it does not.

[0065] In the present document, the meaning of "a plurality of" in the description of the present application is at least two, for example two, three, etc., unless otherwise explicitly and specifically limited.

[0066] Whenever a numerical range is given herein, the range is inclusive of the endpoints and of all individual integers and fractions within the range, and further inclusive of every narrower range that falls within the same overall range, as if such narrower ranges were all explicitly writen herein.

[0067] In a first aspect of the present application, there is provided a liquid dispensing device, with reference to Figure 1 and Figure 2 It is understood that the liquid dispensing device comprises a push rod 10 and a barrel 20. Wherein:

[0068] With reference to Figure 1 It is understood that the push rod 10 comprises a proximal operating portion 13, a distal sealing portion 12, and a deformable portion 11 extending between the proximal operating portion 13 and the distal sealing portion 12, the outer peripheral wall of the deformable portion 11 has a snap 11a protruding in the radial direction of the push rod 10.

[0069] With reference to Figure 1 It is understood that the inner wall of the barrel 20 is sealably and movably coupled with the distal sealing portion 12, the barrel 20 is provided with a push rod inlet 21 at one end, the push rod inlet 21 is provided with a sliding groove 22, and the barrel 20 is provided with a liquid outlet 23 at the other end. With reference to Figure 2 It is understood that the sliding groove 22 comprises a circumferential rotation groove 22a and an inclined groove 22b, the circumferential rotation groove 22a is recessed from the inner wall of the barrel 20 in the direction away from the axis of the barrel 20, the inclined groove 22b is connected with the circumferential rotation groove 22a and is inclined towards the inside of the barrel 20 and extends in the direction of the liquid outlet 23, the circumferential rotation groove 22a is provided with an inlet end 22c, the inlet end 22c is in communication with the push rod inlet 21, the circumferential rotation groove 22a is arranged to be rotationally matched with the circumferential rotation groove 22a when the snap 11a is pushed into the circumferential rotation groove 22a from the inlet end 22c to push the push rod 10; the inclined groove 22b is arranged to be extruded matched with the snap 11a to push down the snap 11a and the push rod 10 when the snap 11a passes through the inclined groove 22b.

[0070] The liquid dispensing device of the present application has one or more of the following technical effects: (1) the buckle 11a located on the deformable portion 11 can be used in conjunction with the slide groove 22 to achieve quantitative liquid dispensing. For example, the buckle 11a can be used to control the depth of the push rod 10 pushed into the cylinder 20, and the circumferential rotating groove 22a can be used to inhibit the buckle 11a from bouncing up under the action of air pressure, thereby facilitating accurate control of the travel distance and stop position of the push rod 10 when the cylinder discharges liquid, thereby improving the accuracy of liquid quantitative dispensing. Compared with the existing manual direct liquid pushing, it is not only simple to operate, but also conducive to quickly and accurately completing the quantitative dispensing of liquid, improving the stability of repeated operations (such as using multiple liquid dispensing devices of the same specification to perform the same operation) or operations by different personnel; (2) simple structure and low cost; (3) liquid quantification can be completed quickly and accurately without additional measuring tools, which is conducive to the conduct of parallel experiments or control experiments; (4) good liquid pushing stability and uniformity; (5) easy to mass produce and promote; (6) suitable for wide promotion and use in multiple industries such as medical care, laboratory, biopharmaceuticals, chemical food, etc.

[0071] In actual operation, refer to Figure 2 It is understood that the buckle 11a is suitable for manually or automatically extending into or out of the circumferential rotation groove 22a from the inlet end 22c. Figure 3 It is understood that the chute 22 includes an inclined groove 22b (refer to Figure 3 (See the detailed diagram G in the figure), since the inclined groove 22b can apply a horizontal rightward force to the buckle 11a and the deformable portion 11, the deformable portion 11 can be deformed, so that the buckle 11a can move along the inclined groove 22b in a direction perpendicular to the slide groove 22, so the axial movement of the push rod 10 along the cylinder 20 is not restricted.

[0072] In actual operation, when the liquid dispensing device is used to distribute the liquid, quantitative distribution can be achieved by extracting the liquid, or by transferring the liquid into the cylinder and then pressing down and rotating the push rod to achieve quantitative distribution.

[0073] For example, when the liquid dispensing device is used to dispense liquid, the liquid can be transferred into the barrel 20 through the push rod inlet 21, and the liquid in the barrel 20 is full, the distal end sealing part 12 of the push rod 10 is inserted into the barrel 20 through the push rod inlet 21 until the buckle 11a enters the entrance end 22c of the chute 22 and cannot be further pressed down, the movement distance of the push rod 10 in the barrel 20 can be limited by the distance between the buckle 11a and the distal end sealing part 12 of the push rod 10, or further combined with the position of the chute 22 and the length of the barrel 20 to limit the movement distance of the push rod 10 in the barrel 20, or the movement distance of the push rod 10 in the barrel 20 is limited by the interval of the two adjacent buckles 11a along the length direction of the push rod 10, so as to realize the quantitative liquid discharge of the liquid; when the liquid in the barrel 20 is not full, that is, there is an air segment between the liquid surface of the liquid in the barrel 20 and the push rod inlet 21 on the barrel 20, for example, the liquid outlet is provided with a permeable membrane, the distal end sealing part 12 of the push rod 10 is inserted into the barrel 20 through the push rod inlet 21 until the buckle 11a enters the entrance end 22c of the chute 22 and cannot be further pressed down, at this time the height of the push rod 10 is kept unchanged, the push rod 10 is rotated to make the buckle 11a rotate with the push rod 10 into the circumferential rotating groove 22a, the air segment between the liquid surface of the liquid in the barrel 20 and the push rod inlet 21 on the barrel 20 is compressed in the process of pressing down the push rod 10, at this time the liquid in the barrel 20 is affected by the gas pressure and flows out from the liquid outlet 23, at the same time the buckle 11a is limited by the circumferential rotating groove 22a and cannot pop up in response to the gas pressure, the movement distance of the push rod 10 in the barrel 20 can be limited by the distance between the buckle 11a and the distal end sealing part 12 of the push rod 10, so as to realize the single quantitative liquid discharge of the liquid; when there is a further liquid discharge demand, the push rod 10 can be further rotated to make the buckle 11a rotate to the inclined groove 22b, and the deformable part 11 is deformed under the extrusion of the inclined groove 22b and the downward thrust, so as to realize the further pressing down of the push rod 10, at this time, if there is still a quantitative liquid discharge demand, the buckle 11a can be further added to realize the cooperation with the chute 22.

[0074] For example, when the liquid in the barrel 20 is full, the volume of each liquid discharge is:

[0075]

[0076] Wherein, R 20 is the radius in the barrel 20, L n is the liquid discharge height when the liquid is quantitatively discharged, for example, the movement distance of the push rod 10 in the barrel 20 is limited by the interval of the two adjacent buckles 11a along the length direction of the push rod 10, L n is the interval of the two adjacent buckles 11a along the length direction of the push rod 10.

[0077] For example, when the cylinder 20 is not filled with liquid and a film is arranged at the liquid outlet, the initial pressing needs to consider the change of the liquid volume caused by the gas compression:

[0078]

[0079] wherein L0 is the distance between the first layer of buckles 11a and the distal sealing part 12, T is the use temperature, P0 is the atmospheric pressure, V0 is the gas volume between the liquid and the push rod, P TH is the bubble point pressure of the liquid and the porous hydrophobic permeable membrane, for the porous hydrophobic permeable membrane P TH = 4δcosθ / D, wherein δ is the surface tension between the liquid and air, θ is the contact angle between the liquid and the permeable membrane, and D is the pore size of the permeable membrane. The liquid volume of the subsequent buckles is calculated according to the formula. For the convenience of understanding, the liquid dispensing device is taken as an example, wherein the push rod 10 is sequentially provided with a first layer of buckles, a second layer of buckles and a third layer of buckles in the direction away from the distal sealing part 12, the liquid dispensing device needs to divide a pure water sample into two parts, each part has a volume of 1 mL, the available amount of the pure water sample is 3.5 mL, the gas volume between the liquid in the cylinder 20 and the push rod 10 is 1 mL, and the bubble point pressure of the medical PTFE permeable membrane is 0.05 MPa. At this time, the liquid dispensing device can be designed according to the following sizes:

[0080] Dimensions Values [R 20 ]]> 5 mm ​ 6.37 mm <L1> 13 mm <L2> 13 mm

[0081] wherein L1 is the distance between the second layer of buckles and the first layer of buckles, L2 is the distance between the third layer of buckles and the second layer of buckles, the sample before the first layer of buckles should be discarded during use, and the samples of the second layer and the third layer are used.

[0082] It can be understood that the deformable part 11 can be deformed recoverably or irrecoverably under the action of an external force. For example, the deformable part 11 can be deformed recoverably or irrecoverably at least under the action of an external force perpendicular to the deformable part 11.

[0083] It can be understood that the circumferential rotating groove 22a is a groove with an opening facing the inside of the cylinder 20 and extending along the circumference of the cylinder 20 (for example, referring to Figure 2 understanding and Figure 3It can be understood that the extension distance of the circumferential rotating groove 22a on the inner wall of the barrel 20 can be flexibly selected according to actual needs. For example, the corresponding arc of the circumferential rotating groove 22a can be 1°-359°, such as 1°, 5°, 10°, 20°, 30°, 40°, 50°, 60°, 70°, 80°, 90°, 100°, 110°, 120°, 130°, 140°, 150°, 180°, 210°, 240°, 270°, 300°, 330° or 359°, or a range formed by any of the above values. Alternatively, the corresponding arc of the circumferential rotating groove 22a can be 10°-150°.

[0084] It can be understood that the groove depth of the circumferential rotating groove 22a (i.e. the depth of the circumferential rotating groove 22a recessed outward from the inner wall of the barrel 20, referring to the distance between the bottom of the circumferential rotating groove 22a and the inner wall of the barrel 20) can be flexibly selected according to the wall thickness of the barrel 20, the inner diameter of the barrel 20, the distance from the outer peripheral wall of the buckle 11a to the axis of the push rod 10, etc., as long as the buckle 11a can rotate in the circumferential rotating groove 22a with the push rod. Figure 2 It can be understood that the groove depth of the circumferential rotating groove 22a (i.e. the depth of the circumferential rotating groove 22a recessed outward from the inner wall of the barrel 20, referring to the distance between the bottom of the circumferential rotating groove 22a and the inner wall of the barrel 20) can be flexibly selected according to the wall thickness of the barrel 20, the inner diameter of the barrel 20, the distance from the outer peripheral wall of the buckle 11a to the axis of the push rod 10, etc., as long as the buckle 11a can rotate in the circumferential rotating groove 22a with the push rod. Figure 3 It can be understood that the groove depth of the circumferential rotating groove 22a (i.e. the depth of the circumferential rotating groove 22a recessed outward from the inner wall of the barrel 20, referring to the distance between the bottom of the circumferential rotating groove 22a and the inner wall of the barrel 20) can be flexibly selected according to the wall thickness of the barrel 20, the inner diameter of the barrel 20, the distance from the outer peripheral wall of the buckle 11a to the axis of the push rod 10, etc., as long as the buckle 11a can rotate in the circumferential rotating groove 22a with the push rod.

[0085] It can be understood that the groove height of the circumferential rotating groove 22a (i.e. the distance between the groove wall on the side of the push rod inlet 21 and the groove wall on the side of the liquid outlet 23 of the circumferential rotating groove 22a) can be flexibly selected according to the extension distance of the buckle 11a along the length direction of the push rod 10 and the required liquid quantity accuracy, which can cooperate with the buckle 11a to rotate in the circumferential rotating groove 22a with the push rod 10 and inhibit the buckle 11a from bouncing to the side of the push rod inlet 21 under the action of air pressure, and the liquid error caused by the cooperation distance between the buckle 11a and the circumferential rotating groove 22a is within an acceptable range. For example, the groove height of the circumferential rotating groove 22a can be slightly larger than the extension distance of the buckle 11a along the length direction of the push rod 10, such as 0.02mm-1mm. Alternatively, under general accuracy requirements, the groove height of the circumferential rotating groove 22a can be 0.5mm-1mm larger than the extension distance of the buckle 11a along the length direction of the push rod 10 (such as 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm or 1mm, etc.), and under high accuracy requirements, the value can be set to be smaller according to the accuracy calculation result, but considering the flexible rotation of the push rod 10 in the circumferential rotating groove 22a, generally the distance should be greater than 0.02mm, such as 0.02mm-0.05mm, for example, greater than 0.02mm, 0.05mm, 0.1mm, 0.2mm, 0.3mm, 0.4mm or 0.45mm, etc.

[0086] It can be understood that the extension distance of the inclined groove 22b in the length direction of the barrel 20 is not particularly limited, and can be selected flexibly by those skilled in the art according to actual needs, as long as the extrusion fit with the buckle 11a can be achieved to push the buckle 11a and the push rod 10 downward.

[0087] It can be understood that the number and setting position of the sliding grooves 22 are matched with the overall distribution and number of the buckle 11a along the length direction and the circumferential direction of the push rod 10.

[0088] It should be noted that in the present application, the "outer circumferential wall of the deformable part 11", the "outer circumferential wall of the deformable beam 11b", the "outer circumferential wall of the buckle 11a", the "outer circumferential wall of the distal sealing part 12", and the "outer circumferential wall of the pressing part 13", the "outer" refers to the direction away from the axis of the push rod 10. In addition, in the "inner wall of the barrel 20 is concave outward", "inside the barrel 20", "the outer circumferential wall of the inlet end 22c", and "the outer circumferential wall of the circumferential rotation groove 22a", the "inner" refers to the direction close to the axis of the barrel 20, and the "outer" refers to the direction away from the axis of the barrel 20.

[0089] In some embodiments of the present application, the specific structure of the deformable part 11 is not particularly limited, and can be selected flexibly by those skilled in the art according to actual needs. For example, the deformable part 11 can be realized by setting a deformable column and a buckle to deform under the action of an external force, or by setting a deformable beam and a buckle to deform under the action of an external force. For example, the deformable part can include a deformable column and a buckle provided on the outer circumferential wall of the deformable column. The deformable column can be an elastic column, which can be formed of an elastic material (such as rubber, etc.), thereby facilitating the extrusion deformation of the deformable part 11 under the action of an external force. Figure 4 、 Figure 5 or Figure 6 It can be understood that the deformable part 11 can include a deformable beam 11b and a buckle 11a. The deformable beam 11b can extend along the length direction of the push rod 10, and the buckle 11a can be provided on the outer circumferential wall of the deformable beam 11b. Thereby facilitating the extrusion deformation of the deformable part 11 under the action of an external force, so that the buckle 11a can move along the inclined surface or perpendicular to the inclined surface.

[0090] In some embodiments of the present application, referring to Figure 4 、 Figure 5 or Figure 6It is understood that the distance between the outer peripheral wall of the deformable beam 11b and the axis of the push rod 10 can be less than or equal to the distance between the outer peripheral wall of the distal sealing portion 12 and the axis of the push rod 10; the distance between the outer peripheral wall of the buckle 11a and the axis of the push rod 10 can be greater than the distance between the outer peripheral wall of the distal sealing portion 12 and the axis of the push rod 10. Thus, it is not only conducive to the advancement of the push rod 10 into the barrel 20, but also can inhibit the push rod 10 from bouncing up in response to the air pressure.

[0091] In some embodiments of the present application, the deformable portion 11 can include one buckle 11a (see Figure 7 It is understood that) or a plurality of buckles 11a (see Figure 1 or Figure 8 It is understood that). When the deformable portion 11 includes a plurality of buckles 11a, the plurality of buckles 11a can be spaced apart along the circumferential direction and / or the length direction of the push rod 10. Among them, the number and interval length of the buckles 11a spaced apart along the length direction of the push rod 10 can be adjusted to control the number of single-barrel liquid quantification and the amount of liquid quantification; in addition, when the distance of the buckle 11a close to the distal sealing portion 12 of the push rod 10 is fixed in the length direction of the push rod 10, the number and interval angle of the buckles 11a spaced apart along the circumferential direction of the push rod 10 can be adjusted to improve the fixing effect of the slide groove 22 on the buckle 11a and the push rod 10, and improve the stability of the buckle 11a after entering the circumferential rotating groove 22a to keep the height of the push rod 10 unchanged.

[0092] In some embodiments of the present application, the push rod 10 can include one layer of buckles 11a (see Figure 7 or Figure 8 It is understood that) or a plurality of layers of buckles 11a (see Figure 1 It is understood that). When the push rod 10 includes a plurality of layers of buckles 11a, the plurality of layers of buckles 11a can be spaced apart along the length direction of the push rod 10, the number of buckles 11a in each layer can be one or more, and the plurality of buckles 11a in the same layer can be spaced apart along the circumferential direction of the push rod 10, and the distance between the buckles 11a in the same layer and the distal sealing portion 12 in the length direction of the push rod 10 is equal.

[0093] For example, referring to Figure 7 It is understood that the push rod 10 can include only one layer of buckles 11a, and the layer of buckles 11a can include only one buckle 11a.

[0094] For example, referring to Figure 8 It is understood that the push rod 10 can include only one layer of buckles 11a, and the layer of buckles 11a can include a plurality of buckles 11a spaced apart along the circumferential direction of the push rod 10. Thus, it is conducive to improve the fixing effect of the slide groove 22 on the buckle 11a and the push rod 10, and improve the stability of the buckle 11a after entering the circumferential rotating groove 22a to keep the height of the push rod 10 unchanged.

[0095] Exemplarily, the push rod 10 can include multiple layers of buckles 11a, and each layer of buckles 11a can independently include only one buckle 11a. Thus, the descending distance of the push rod 10 in the barrel 20 can be controlled by regulating the setting positions of different layers of buckles in the length direction of the push rod and / or the distance between adjacent layers of buckles 11a, so as to realize multiple times of quantitative liquid discharge of the single-barrel liquid. It can be understood that the number of layers of buckles 11a on the push rod 10 and the distance between adjacent two layers of buckles 11a in the length direction of the push rod 10 can be flexibly selected according to actual needs, for example, the number of layers of buckles 11a can be 2, 3, 4, 5, 6, 7, 8, 9, 10, 15 or 20, etc.

[0096] Exemplarily, referring to Figure 1 It is understood that the push rod 10 can include multiple layers of buckles 11a, and at least one layer of buckles 11a includes multiple buckles 11a spaced along the circumference of the push rod 10; or, each layer of buckles 11a can independently include multiple buckles 11a spaced along the circumference of the push rod 10. It can be understood that the number of multiple buckles 11a in the same layer can be flexibly selected according to actual needs, for example, it can be 2, 3, 4, 5, 6, 7, 8, 9 or 10, etc.

[0097] In some embodiments of the present application, referring to Figure 1 It is understood that the push rod 10 can include multiple layers of buckles 11a, and the number of buckles 11a in each layer can be multiple, the number of buckles 11a in different layers is the same, and in adjacent two layers of buckles 11a, the arc corresponding to the adjacent two buckles 11a in one layer is the same as the arc corresponding to the adjacent two buckles 11a in the other layer. Thus, multiple times of quantitative liquid discharge of the single-barrel liquid can be realized, and it is also beneficial to the smooth entry of each layer of buckles 11a into the chute 22, and improve the fixing effect of the chute 22 on the buckle 11a and the push rod 10, and improve the stability of each layer of buckles 11a keeping the height of the push rod 10 unchanged after entering the circumferential rotating groove 22a.

[0098] Further, referring to Figure 1 It is understood that the number of buckles 11a in each layer can be two. Thus, it is beneficial to improve the fixing effect of the chute 22 on the buckle 11a and the push rod 10, improve the stability of each layer of buckles 11a keeping the height of the push rod 10 unchanged after entering the circumferential rotating groove 22a, and also simplify the structure of the device.

[0099] Further, referring to Figure 1It is understood that in the same layer, the arc corresponding to the two adjacent buckles 11a can be 100°-180°, for example, can be 100°, 120°, 135°, 150°, 165° or 180°, etc., or can be a range composed of any of the above values. Alternatively, the arc corresponding to the two adjacent buckles 11a can be 180°.

[0100] In some embodiments of the present application, referring to Figure 1 It is understood that the push rod 10 can include two layers of buckles 11a, the number of buckles 11a in each layer is two, and the arc corresponding to the two adjacent buckles 11a in one layer is the same as the arc corresponding to the two adjacent buckles 11a in the other layer.

[0101] It can be understood that in the liquid distribution device, the number and setting position of the chute 22 are matched with the distribution layer number, the number of buckles 11a in each layer, and the distribution position of the buckle 11a.

[0102] In some embodiments of the present application, referring to Figure 4 、 Figure 5 or Figure 6 It is understood that the deformable part 11 can include a plurality of deformable beams 11b spaced along the circumference of the push rod 10, and each deformable beam 11b can be independently provided with at least one buckle 11a. Thus, the overall distribution of the buckles 11a on the push rod 10 can be controlled by adjusting the number of deformable beams 11b and the distribution of the buckles 11a on the deformable beams 11b. Alternatively, the buckles 11a can be arranged one by one with the deformable beams 11b, and one buckle 11a is arranged on each deformable beam 11b.

[0103] In some embodiments of the present application, referring to Figure 3 It is understood that the distance between the outer peripheral wall of the inlet end 22c of the chute 22 and the axis of the cylinder 20 can be greater than or equal to the distance between the outer peripheral wall of the circumferential rotating groove 22a and the axis of the cylinder 20. Alternatively, the distance between the outer peripheral wall of the inlet end 22c of the chute 22 and the axis of the cylinder 20 can be greater than the distance between the outer peripheral wall of the circumferential rotating groove 22a and the axis of the cylinder 20, thereby more facilitating the buckle 11a to extend into the circumferential rotating groove 22a through the inlet end 22c.

[0104] In some embodiments of the present application, referring to Figure 3 It is understood that the distance from the connection between the side of the inclined groove 22b of the chute 22 close to the push rod inlet 21 to the axis of the cylinder 20 gradually decreases in the direction away from the circumferential rotating groove 22a. Thus, it is beneficial to gradually increase the extrusion force received by the buckle 11a and the deformable part 11, so that the buckle 11a can move along the inclined surface or perpendicular to the inclined surface direction, realizing the pressing demand of the push rod 10.

[0105] In some embodiments of the present application, reference Figure 3 It is understood that the distance between the connection point between the side of the inclined groove 22b of the chute 22 near the liquid outlet 23 and the cylinder 20 and the axis of the cylinder 20 and the distance between the inner wall of the cylinder 20 and the axis of the cylinder 20 can be the same. In this way, the overall inner diameter of the cylinder 20 can be kept unchanged, which further facilitates the movement of the push rod 10 along the length direction of the cylinder 20.

[0106] In some embodiments of the present application, the inclined groove 22b of the slide groove 22 can be arranged on the side of the circumferentially rotating groove 22a extending circumferentially along the inner wall of the cylinder 20, or can be arranged on the side of the circumferentially rotating groove 22a facing the inside of the cylinder 20, or can be arranged on the side of the circumferentially rotating groove 22a facing the inside of the cylinder and close to the liquid outlet 23 and extending in the direction away from the circumferentially rotating groove 22a in the circumferential direction of the cylinder 20.

[0107] In some embodiments of the present application, the buckle 11a may be a deformable buckle, which can further facilitate the deformation of the deformable portion 11 under the pressure of the inclined groove 22b, thereby achieving the downward pressing requirement of the push rod 10.

[0108] In some embodiments of the present application, the deformable portion 11 may be an elastically deformable portion. For example, the deformable portion 11 may include an elastically deformable beam and / or an elastic clip. The use of an elastically deformable portion allows the deformable portion 11 to form a recoverable deformation, facilitating the recycling of the push rod 10. It should be noted that the specific material of the elastically deformable portion is not particularly limited, and those skilled in the art may flexibly select the material based on actual needs, for example, a commonly used elastically deformable material in the field.

[0109] In some embodiments of the present application, reference Figure 6 It is understood that the deformable beam 11b may include a cantilever beam, and the buckle 11a located on the cantilever beam may be provided at a free end of the cantilever beam.

[0110] In some embodiments of the present application, reference Figure 4 or Figure 5 It is understood that the deformable beam 11 b may include a double-ended fixed beam, and the buckle 11 a located on the double-ended fixed beam may be provided between the two ends of the double-ended fixed beam.

[0111] In some embodiments of the present application, reference Figure 9 It is understood that a fracture 14 may be provided on one side of the double-ended fixed beam close to the distal sealing portion 12. This is beneficial for the deformable portion 11 to form an irreversible deformation ( Figure 10 A schematic diagram showing the deformable beam 11b undergoing irreversible deformation at the fracture 14 after use is shown), thereby preventing the push rod 10 from being reused multiple times.

[0112] In some embodiments of the present application, the specific type of the distal sealing portion 12 is not particularly limited, and can be selected by those skilled in the art according to actual needs. For example, the distal sealing portion 12 can be an elastic distal sealing portion. For another example, the distal sealing portion 12 can include, but is not limited to, a sealing ring and / or a piston. It should be noted that the specific material of the elastic distal sealing portion, the sealing ring and the piston is not particularly limited, and can be selected by those skilled in the art according to actual needs, for example, a common elastic sealing material in the art can be selected as long as the sealing cooperation and relative movement between the inner wall of the barrel 20 and the distal sealing portion 12 can be achieved.

[0113] In some embodiments of the present application, the liquid outlet 23 of the barrel 20 can also be selected according to actual needs whether to be provided with a sample enrichment layer 24 and / or a sealing layer (not shown). The sample enrichment layer 24 can be used to adsorb target substances in the sample to be discharged, and the sealing layer can be used to reduce the risk of liquid leakage before discharge. For example, when there is no need to adsorb target substances, the sample enrichment layer can not be provided; when the sample to be discharged in the barrel 20 is a viscous liquid which is not easy to flow under the action of gravity, the sealing layer can not be provided at the liquid outlet 23.

[0114] It should be noted that the specific type of the sample enrichment layer 24 and the sealing layer is not particularly limited, and can be selected by those skilled in the art according to actual needs.

[0115] For example, the sample enrichment layer 24 can include, but is not limited to, a permeable membrane, a sponge, a selectively absorbable membrane, etc. Among them, the specific type of the selectively absorbable membrane can be selected according to actual detection needs, for example, can include, but is not limited to, a hydrophobic silicon-based material membrane, a specific antibody modified immunophilic membrane or a nucleic acid enrichment membrane, etc.

[0116] For example, the sealing layer can include, but is not limited to, a permeable membrane and an aluminum film. In some embodiments of the present application, referring to Figure 3 It is understood that the permeable membrane 24 can be provided at the liquid outlet 23 of the barrel 20. The provision of the permeable membrane is beneficial to inhibit the sample to be discharged from flowing out under the action of gravity, thereby further improving the accuracy of the liquid quantitative discharge.

[0117] In some embodiments of the present application, referring to Figure 1 It is understood that the side of the proximal operation portion 13 away from the distal sealing portion 12 is provided with a pressing portion 13a. Therefore, the pressing and rotating operation of the push rod 10 is further facilitated.

[0118] In some embodiments of the present application, referring to Figure 1It is understood that the distance from the outer peripheral wall of the pressing portion 13a to the axis of the push rod 10 can be greater than the distance from the outer peripheral wall of the deformable portion 11 to the axis of the push rod 10. This further facilitates the push-pull operation of the push rod 10 in the barrel 20.

[0119] For the convenience of understanding the specific use method of the liquid dispensing device of the present application, the use method of the liquid dispensing device is exemplarily described below with reference to Figure 1 、 Figure 2 and Figure 11

[0120] Step S1: a permeable membrane 24 is provided at the liquid outlet of the barrel 20, and a sample of liquid to be dispensed is added into the barrel 20 through the push rod inlet 21;

[0121] Step S2: the push rod 10 is inserted into the barrel 20 in the direction shown in the figure until the first layer of buckles 11a1 enters the inlet end 22c of the sliding groove 22 and cannot be further pressed down;

[0122] Step S3: the height of the push rod 10 is kept unchanged, and clockwise rotation is performed so that the first layer of buckles 11a1 is located in the circumferential rotation groove 22a, at this time the liquid is subjected to the action of air pressure for the first time and flows out through the permeable membrane 24, and the first layer of buckles 11a1 is limited by the circumferential rotation groove 22a and cannot be popped up in response to the action of air pressure;

[0123] Step S4: further pressing down, at this time the first layer of buckles 11a1 is located at the inclined groove 22b, and the push rod 10 can be pressed down until the second layer of buckles 11a2 enters the inlet end 22c of the sliding groove 22 and cannot be further pressed down;

[0124] Step S5: the height of the push rod 10 is kept unchanged, and clockwise rotation is performed so that the second layer of buckles 11a2 is located in the circumferential rotation groove 22a, at this time the liquid is subjected to the action of air pressure for the second time and flows out through the permeable membrane 24, and the second layer of buckles 11a2 is limited by the circumferential rotation groove 22a and cannot be popped up in response to the action of air pressure;

[0125] Step S6: further pressing down, at this time the second layer of buckles 11a2 is located at the inclined groove 22b, and the push rod 10 can be pressed down until it is completely inserted, at this time the liquid is subjected to the action of air pressure for the third time and flows out through the permeable membrane 24.

[0126] In the second aspect of the present application, a detection system is provided, which comprises the liquid dispensing device provided in the first aspect of the present application. The use of the above-mentioned liquid dispensing device in the detection field is advantageous for further improving the detection accuracy.

[0127] In some embodiments of the present application, the detection system can comprise a detection unit, and the sample inlet of the detection unit can be cooperatively arranged with the liquid outlet of the liquid dispensing device. This further facilitates the detection operation.​

[0128] In some embodiments of the present application, the detection unit can include, but is not limited to, one or more of a test strip, an electrochemical detection device, and an optical detection device.

[0129] The present application has been described in detail by using general description and specific embodiments above, but some modifications or improvements can be made on the basis of the present application, and any combination can be made according to the needs, which is obvious to those skilled in the art. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the present application, all belong to the scope of the present application claimed.

Claims

1. A liquid dispensing device, characterized in that: include: A push rod comprising a proximal operating portion, a distal sealing portion, and a deformable portion extending between the proximal operating portion and the distal sealing portion, wherein an outer peripheral wall of the deformable portion has a buckle, and the buckle protrudes radially along the push rod; and The cylinder body, the inner wall of the cylinder body and the distal sealing portion can be sealed and moved relatively, and one end of the cylinder body is provided with a push rod inlet, and the other end of the cylinder body is provided with a liquid outlet, and a slide groove is provided at the push rod inlet, and the slide groove includes a circumferential rotation groove and an inclined groove, and the circumferential rotation groove is recessed from the inner wall of the cylinder body in the direction away from the axis of the cylinder body, and the inclined groove is connected to the circumferential rotation groove and is inclined toward the cylinder body and extends in the direction of the liquid outlet, and the circumferential rotation groove is provided with an inlet end, and the inlet end is connected with the push rod inlet, and the circumferential rotation groove is configured to rotate with the circumferential rotation groove when the push rod is pushed to make the buckle extend from the inlet end into the circumferential rotation groove; the inclined groove is configured to squeeze and cooperate with the buckle when the buckle passes through the inclined groove to push the buckle and the push rod downward.

2. The liquid dispensing device according to claim 1, wherein: The deformable portion includes a deformable beam and the buckle. The deformable beam extends along the length direction of the push rod, and the buckle is arranged on the outer peripheral wall of the deformable beam.

3. The liquid dispensing device according to claim 2, characterized in that: The distance between the outer peripheral wall of the deformable beam and the axis of the push rod is less than or equal to the distance between the outer peripheral wall of the distal sealing part and the axis of the push rod; the distance between the outer peripheral wall of the buckle and the axis of the push rod is greater than the distance between the outer peripheral wall of the distal sealing part and the axis of the push rod.

4. The liquid dispensing device according to any one of claims 1 to 3, characterized in that: The deformable portion includes a plurality of deformable beams spaced apart along the circumference of the push rod, and each of the deformable beams is independently provided with at least one buckle.

5. The liquid dispensing device according to any one of claims 1 to 4, characterized in that: The push rod includes one or more layers of the buckles, and the multiple layers of the buckles are arranged at intervals along the length direction of the push rod. The number of the buckles in each layer is one or more, and the multiple buckles located in the same layer are arranged at intervals along the circumference of the push rod, and in the length direction of the push rod, the distance between the buckles located in the same layer and the distal sealing part is equal.

6. The liquid dispensing device according to any one of claims 1 to 5, characterized in that: The push rod includes multiple layers of buckles, each layer has multiple buckles, the number of buckles in different layers is the same, and in two adjacent layers of buckles, the curvature corresponding to two adjacent buckles on one layer is the same as the curvature corresponding to two adjacent buckles on the other layer.

7. The liquid dispensing device according to any one of claims 2 to 6, characterized in that: The deformable beam comprises a cantilever beam, and the buckle located on the cantilever beam is provided at a free end of the cantilever beam; and / or, The deformable beam comprises a double-end fixed beam, and the buckle on the double-end fixed beam is arranged between the two ends of the double-end fixed beam.

8. The liquid dispensing device according to any one of claims 2 to 7, characterized in that: The deformable beam includes a double-end fixed beam, and a fracture is provided on a side of the double-end fixed beam close to the distal sealing portion.

9. The liquid dispensing device according to any one of claims 1 to 7, characterized in that: A sample enrichment layer and / or a sealing layer is provided at the liquid outlet.

10. A detection system, characterized in that: A liquid dispensing device comprising the liquid dispensing device according to any one of claims 1 to 9.

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