Ginseng essence active yuan cream capable of reinforcing qi and nourishing blood and preparation method of ginseng essence active yuan cream

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a Qi-reinforcing and blood-nourishing ginseng essence active yuan cream and a preparation method thereof. The ginseng essence active yuan is prepared from the following raw materials in parts by weight: 8 to 12 parts of rhizoma polygonati, 80 to 100 parts of fructus lycii, 4 to 6 parts of ginseng, 80 to 100 parts of maca, 0.4 to 0.6 part of penis et testis cervi, 3 to 7 parts of radix polygonati officinalis, 80 to 100 parts of mulberry, 80 to 100 parts of black bean, 4 to 6 parts of poria cocos, 40 to 60 parts of rhizoma dioscoreae, 8 to 12 parts of lotus seed, 80 to 100 parts of fructus ziziphi jujubae, 8 to 12 parts of longan aril and 30 to 50 parts of isomaltooligosacharide. According to the ginseng essence active yuan cream, the fructus lycii, the rhizoma polygonati, the radix polygonati officinalis, the mulberries and the black beans are used for filling kidney yin, the maca, the penis et testis cervi and the ginseng are used for reinforcing primordial qi and yang, and the longan aril and the Chinese dates are used for replenishing blood, tonifying spleen and soothing nerves. Poria cocos permeates dampness and heat in the spleen and traits heart and kidney, so that tonifying and reducing are both considered, and nourishing is continued. Chinese yam and lotus seed stop diarrhea, invigorate spleen, nourish yin, tonify kidney and arrest seminal The isomaltooligosacharide can fuse and carry various medicines, harmonize the flavor of the medicines, invigorate the spleen, benefit the middle warmer, relax bowel and promote metabolism.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically a ginseng essence and angelica root extract for invigorating qi and nourishing blood, and its preparation method. Background Technology

[0002] Traditional blood-tonifying herbal pastes (such as Siwu Tang) are mostly warming and drying in nature. Classic blood-tonifying formulas (such as Siwu Tang and Danggui Buxue Tang) mainly use warm herbs such as angelica, astragalus, and chuanxiong. Long-term use can easily lead to symptoms of internal heat such as dry mouth and tongue, and constipation, making them unsuitable for those with yin deficiency and excessive internal heat. The application of maca in qi-tonifying and blood-nourishing compound formulas has not yet been reported.

[0003] This invention develops a more balanced formula that nourishes the kidneys and replenishes essence, as well as invigorates qi and nourishes blood. It uses yin-nourishing herbs such as Polygonatum and Solomon's seal to balance the warming and drying properties, improve the side effects of warming and drying, and achieves "nourishing without drying" through the triangular combination of "Polygonatum-Maca-Deer Antler". Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a ginseng essence and angelica root extract for invigorating qi and nourishing blood, as well as its preparation method, so as to solve the problems mentioned in the above-mentioned technical background.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] In a first aspect, the present invention provides a Qi-tonifying and blood-nourishing ginseng essence and angelica root extract, which is composed of the following ingredients by weight: 8-12 parts of polygonatum, 80-100 parts of wolfberry, 4-6 parts of ginseng, 80-100 parts of maca, 0.4-0.6 parts of deer antler velvet, 3-7 parts of polygonatum odoratum, 80-100 parts of mulberry, 80-100 parts of black bean, 4-6 parts of poria cocos, 40-60 parts of yam, 8-12 parts of lotus seed, 80-100 parts of jujube, 8-12 parts of longan pulp, and 30-50 parts of isomaltooligosaccharide. The ginseng is artificially cultivated for five years or less; the deer antler velvet comes from artificially raised sika deer (compliant with the 2020 edition of the Chinese Pharmacopoeia).

[0007] Preferably, the ginseng essence and angelica extract is composed of the following ingredients by weight: 10 parts of polygonatum, 90 parts of wolfberry, 5 parts of ginseng, 90 parts of maca, 0.5 parts of deer antler velvet, 5 parts of polygonatum odoratum, 90 parts of mulberry, 90 parts of black bean, 5 parts of poria cocos, 50 parts of yam, 10 parts of lotus seed, 90 parts of jujube, 10 parts of longan pulp, and 40 parts of isomaltooligosaccharide.

[0008] Preferably, the ginseng essence and cinnamon extract has the effects of invigorating qi and nourishing blood, nourishing yin and clearing heat.

[0009] Secondly, the present invention provides a method for preparing a Qi-tonifying and blood-nourishing ginseng essence and angelica root extract, comprising the following steps:

[0010] S1. Prepare ingredients according to the formula;

[0011] S2. Take Polygonatum sibiricum, Lycium barbarum, Ginseng, Maca, Deer antler velvet, Polygonatum odoratum, Mulberry, Black bean, Poria cocos, Dioscorea opposita, Lotus seed, Jujube, and Longan pulp, soak them in water, decoct them three times, and combine the filtrates to obtain the Chinese herbal extract.

[0012] S3. Add isomaltooligosaccharide to the herbal extract obtained in step S2, mix well, and then reduce to a paste. When the heated paste reaches a "honeycomb" boiling state, begin the reduction process. First, control the heat carefully; too much heat will harden it, too little will make it runny. Second, control the timing of the reduction; within half a minute to one minute, it should form "drops forming beads" and "hanging like a flag." After reducing, while still hot, portion into containers, let cool, and then seal to obtain the Ginseng and Angelica Extract Paste. The concentration of raw herbs in the Ginseng and Angelica Extract Paste is 0.55~0.70g / g, meaning each gram of paste contains 0.55~0.70g of raw herbs (isomaltooligosaccharide is not included in the raw herb dosage).

[0013] Preferably, in step S2, water is added at a ratio of 8-10 times the amount of medicinal materials, and the herbs are soaked for 30-40 minutes before the first decoction is performed, which lasts for 1-2.5 hours.

[0014] Preferably, in step S2, the second and third decoctions are both done with 5-7 times the amount of medicinal materials, and the decoctions are carried out for 0.5-1.5 hours.

[0015] Preferably, the concentration of raw medicinal materials in the Ginseng Essence and Angelica Extract obtained in step S3 is 0.63 g / g.

[0016] Ideally, the paste should be stirred continuously throughout the entire process, skimming off any foam to prevent scorching.

[0017] The formulation and compatibility of the principal, assistant, adjuvant, and guide herbs in this invention are as follows:

[0018] Principal herb: Polygonatum sibiricum

[0019] The main ingredients are: wolfberry, ginseng, maca, deer antler velvet, Solomon's seal rhizome, mulberry, and black beans.

[0020] Medicinal herbs: Poria cocos, Dioscorea opposita, Nelumbo nucifera, Jujube, Longan pulp,

[0021] Adjuvant: Isomaltooligosaccharide

[0022] The kidneys are the foundation of innate essence, governing bones, storing essence and producing marrow, and controlling true yin and true yang. With age, these functions gradually diminish and are depleted. Since essence and blood share the same origin, both require appropriate replenishment. Nourishing yin and kidneys, seeking yang within yin, and harmonizing yin and yang are essential for effectiveness. Referring to classical formulas such as the Eight-Ingredient Kidney Qi Pill and the Six-Ingredient Rehmannia Pill, this formula selects medicinal and edible ingredients. Goji berries, polygonatum, polygonatum, mulberry, and black beans replenish kidney yin. A thin and rapid pulse on the left radial artery indicates insufficient yin fluid, requiring further replenishment. Maca, deer antler velvet, and ginseng replenish vital energy and yang, addressing fatigue, weakness, and cold intolerance. In this formula, they represent seeking yang within yin. Longan pulp and jujubes nourish blood, strengthen the spleen, and calm the mind, addressing a thin pulse. Pale complexion and lips, dizziness, require replenishment. Since essence and blood share the same origin, this is beneficial for kidney tonification. Poria cocos gently drains damp heat from the spleen, harmonizing the heart and kidneys, achieving a balance of tonification and purgation for sustained nourishment. Yam and lotus seeds stop diarrhea, strengthen the spleen, and nourish yin, all contributing to regulating the flow of essence and replenishing kidney essence. Isomaltooligosaccharides can harmonize and carry various medicines, regulate their flavors, strengthen the spleen and stomach, moisten the intestines and promote bowel movements, and accelerate metabolism. The entire formula nourishes kidney yin and regulates kidney yang at multiple stages, and can be widely used for various diseases related to kidney deficiency, such as lower back pain due to kidney deficiency, dizziness and fatigue due to blood deficiency, impotence, premature ejaculation, infertility due to kidney deficiency, tinnitus and hearing loss, decreased vision, heel pain, and toothache due to deficiency heat.

[0023] Compared with the prior art, the beneficial effects of the present invention are:

[0024] 1. This invention provides a Qi-tonifying and blood-nourishing Ginseng Essence and Angelica Root Paste. This formula uses wolfberry, polygonatum, Solomon's seal, mulberry, and black beans to replenish kidney yin; maca, deer antler velvet, and ginseng to replenish vital energy and yang; longan pulp and jujube to nourish blood, strengthen the spleen, and calm the mind. Poria cocos gently drains damp-heat from the spleen, harmonizes the heart and kidneys, achieving a balance of tonification and purgation, providing sustained nourishment. Dioscorea opposita and lotus seeds stop diarrhea, strengthen the spleen, nourish yin, tonify the kidneys, and astringe essence. Isomaltooligosaccharide can harmonize and carry the various herbs, regulate their flavor, strengthen the spleen and benefit the middle jiao, moisten the intestines and promote bowel movements, and promote metabolism.

[0025] 2. The synergistic effect of the Polygonatum, ginseng, maca, deer antler, Polygonatum odoratum, black bean and longan pulp contained in the Ginseng Essence and Ginseng Extract of this invention has a significant effect on invigorating qi and nourishing blood.

[0026] 3. The synergistic effect of Polygonatum, Maca, and Polygonatum in Shenjing Guiyuan Paste has a significant effect of nourishing Yin and clearing heat, and can improve the side effects of warm dryness. Attached Figure Description

[0027] Figure 1 The product of the Ginseng Essence and Angelica Extract Ointment obtained in Example 1 of this invention. Figure 1 ;

[0028] Figure 2 The product of the Ginseng Essence and Angelica Extract Ointment obtained in Example 1 of this invention. Figure 2 ;

[0029] Figure 3 Bar chart showing the white blood cell count (WBC) in the peripheral blood of mice in each group;

[0030] Figure 4A bar chart showing the number of red blood cells (RBCs) in the peripheral blood of mice in each group;

[0031] Figure 5 A bar chart showing the hemoglobin concentration (HGB) in the peripheral blood of mice in each group. Detailed Implementation

[0032] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that, unless otherwise specified, the following embodiments and features described therein can be combined with each other.

[0033] Example 1

[0034] A Qi-tonifying and blood-nourishing ginseng essence and angelica root extract, by weight, consists of the following ingredients: 10 parts Polygonatum sibiricum, 90 parts Lycium barbarum, 5 parts ginseng, 90 parts maca, 0.5 parts deer antler velvet, 5 parts Polygonatum odoratum, 90 parts mulberry, 90 parts black beans, 5 parts Poria cocos, 50 parts Dioscorea opposita, 10 parts lotus seeds, 90 parts jujubes, 10 parts longan pulp, and 40 parts isomaltooligosaccharide. The ginseng is artificially cultivated for five years or less; the deer antler velvet comes from artificially raised sika deer.

[0035] A method for preparing a Qi-tonifying and blood-nourishing ginseng essence and angelica root extract includes the following steps:

[0036] S1. Prepare ingredients according to the formula;

[0037] S2. Take Polygonatum sibiricum, Lycium barbarum, Ginseng, Maca, Deer antler velvet, Polygonatum odoratum, Mulberry, Black bean, Poria cocos, Dioscorea opposita, Lotus seed, Jujube, and Longan pulp, soak them in water, decoct them three times, and combine the filtrates to obtain the Chinese herbal extract.

[0038] S3. Add isomaltooligosaccharide to the herbal extract obtained in step S2, mix and stir well, then reduce to a paste. When the heated paste reaches a "honeycomb" boiling state, reduce to a paste and finish. While still hot, dispense into containers, cool, and seal to obtain the Ginseng and Angelica Extract Paste. At this point, the crude drug concentration of the Ginseng and Angelica Extract Paste is 0.63 g / g. The product image of the Ginseng and Angelica Extract Paste is shown below. Figure 1 , 2 As shown.

[0039] Example 2

[0040] A ginseng essence and blood-nourishing paste, by weight, is composed of the following ingredients: 8 parts Polygonatum sibiricum, 80 parts Lycium barbarum, 4 parts ginseng, 100 parts maca, 0.4 parts deer antler velvet, 7 parts Polygonatum odoratum, 100 parts mulberry, 100 parts black bean, 4 parts Poria cocos, 60 parts Dioscorea opposita, 8 parts lotus seed, 80 parts jujube, 8 parts longan pulp, and 50 parts isomaltooligosaccharide.

[0041] Example 3

[0042] A ginseng essence and blood-nourishing paste, by weight, is composed of the following ingredients: 12 parts Polygonatum sibiricum, 100 parts Lycium barbarum, 6 parts ginseng, 80 parts maca, 0.6 parts deer antler velvet, 3 parts Polygonatum odoratum, 80 parts mulberry, 80 parts black bean, 6 parts Poria cocos, 40 parts Dioscorea opposita, 12 parts lotus seed, 100 parts jujube, 12 parts longan pulp, and 30 parts isomaltooligosaccharide.

[0043] Comparative Example 1

[0044] This comparative example is similar to Example 1, except that Polygonatum sibiricum is removed.

[0045] Comparative Example 2

[0046] This comparative example is similar to Example 1, except that ginseng is removed.

[0047] Comparative Example 3

[0048] This comparative example is similar to Example 1, except that maca is removed.

[0049] Comparative Example 4

[0050] This comparative example is similar to Example 1, except that the deer penis is removed.

[0051] Comparative Example 5

[0052] This comparative example is similar to Example 1, except that Solomon's seal is removed.

[0053] Comparative Example 6

[0054] This comparative example is similar to Example 1, except that black beans are removed.

[0055] Comparative Example 7

[0056] This comparative example is similar to Example 1, except that the longan pulp is removed.

[0057] The preparation methods of Examples 2-3 and Comparative Examples 1-7 are similar to those of Example 1.

[0058] Experimental Example 1: Effects of Ginseng and Angelica Extract Paste on Mice with Blood Deficiency

[0059] 1. Experimental subjects: C57BL / 6J mice, 6-8 weeks old, weighing (20±2)g, purchased from Jiangsu Airingfei Biotechnology Co., Ltd., were fed routinely for 1 week before the experiment.

[0060] 2. Experimental methods:

[0061] Blood deficiency model: mice 60 A single whole-body irradiation with Co-γ rays resulted in a dose of 3.5 Gy at a rate of 1.27 Gy / min and an irradiation distance of 4 m.

[0062] After one week of routine feeding, 120 mice were randomly divided into three groups: a normal group, a model group, and a treatment group (containing the ginseng extract prepared in Examples 1-3 and Comparative Examples 1-7), with 10 mice in each group. Except for the normal group, all other groups underwent modeling. Immediately after modeling, the mice were administered the drug via gavage. The treatment groups received 1.95 g / kg or 0.2 ml / 10 g of the drug via gavage once daily for 7 consecutive days. The normal group and the model group received an equal volume of physiological saline via gavage.

[0063] 3. Peripheral blood count

[0064] On day 2 after the last administration, peripheral blood was collected from the tail vein of mice, and peripheral blood counts were analyzed using a Sysmex-820 automated blood cell counter. The white blood cell count (WBC), red blood cell count (RBC), and hemoglobin concentration (HGB) of peripheral blood in each group of mice are shown in Tables 1-3.

[0065] Table 1

[0066] Group <![CDATA[WBC(10 9 / L)]]> <![CDATA[RBC(10 12 / L)]]> HGB(g / L) normal group 14.32±1.51 10.54±0.74 171.3±10.6 Model group 3.64±0.42 6.71±0.88 136.5±8.7 Example 1 7.28±0.65 9.37±0.91 161.1±10.2 Example 2 6.91±0.71 8.98±1.04 157.6±9.4 Example 3 7.04±0.54 9.15±1.21 160.2±11.3 Comparative Example 1 5.15±0.43 7.12±0.65 143.2±9.5 Comparative Example 2 5.31±0.64 7.23±0.71 143.8±7.6 Comparative Example 3 5.57±0.45 7.30±0.57 144.5±8.5 Comparative Example 4 5.43±0.52 7.28±0.62 144.1±8.4 Comparative Example 5 5.70±0.63 7.46±0.59 145.5±9.1 Comparative Example 6 5.61±0.58 7.38±0.72 144.9±10.0 Comparative Example 7 5.75±0.57 7.51±0.75 146.2±9.8

[0067] From Table 1 and Figure 3-5 It can be seen that, compared with the model group, Examples 1-3 all significantly increased the number of peripheral blood leukocytes, erythrocytes, and hemoglobin concentration. This indicates that the Shenjing Guiyuan Paste of the present invention has a blood-tonifying effect. Compared with Comparative Examples 1-7, the number of peripheral blood leukocytes, erythrocytes, and hemoglobin concentration in Example 1 were significantly increased, indicating that the Polygonatum sibiricum, ginseng, maca, deer antler velvet, Polygonatum odoratum, black beans, and longan pulp contained in Shenjing Guiyuan Paste have a synergistic effect, resulting in a significant qi-tonifying and blood-nourishing effect.

[0068] Experimental Example 2: Effects of Ginseng and Angelica Extract Paste on a Rats with Yin Deficiency and Hyperactivity of Fire

[0069] 1. Animal grouping: SPF-grade male SD rats, 10 weeks old, weighing 330-360 g, were purchased from Jiangsu Airingfei Biotechnology Co., Ltd. After one week of routine feeding, 60 rats were randomly divided into normal group, model group, and drug treatment group (Example 1, Comparative Example 1, Comparative Example 3 and Comparative Example 5), with 10 rats in each group.

[0070] 2. Experimental Methods

[0071] The normal group and the model group were fed normally every day, and were given drinking water by gavage in the morning at a volume of 10 ml / kg. The drug treatment group was pre-administered at a dose of 1.35 g / kg at a volume of 10 ml / kg for 7 consecutive days. From day 8 onwards, the model group and the drug treatment group were given 150 mg / kg of levothyroxine suspension by gavage in the morning. About 90 minutes later, the drug treatment group was given the corresponding dose of drug by gavage at a volume of 10 ml / kg for 14 consecutive days.

[0072] 3. Determination of cAMP and cGMP levels in rat plasma

[0073] One hour after the last administration (day 21), whole blood from rats was collected and placed in heparinized centrifuge tubes. After centrifugation at 4000 rpm for 10 min, plasma was separated and stored at -20°C for later analysis. The levels of cAMP and cGMP were detected using an enzyme-linked immunosorbent assay (ELISA), following the kit instructions. The cAMP / cGMP ratio was calculated, and the results are shown in Table 2. The cAMP and cGMP ELISA kits were purchased from Shanghai Runyu Biotechnology Co., Ltd.

[0074] Table 2

[0075] Group cAMP (pmol / ml) cGMP (pmol / ml) cAMP / cGMP normal group 25.6±2.1 12.2±1.0 2.1 Model group 76.3±3.7 9.2±0.8 8.2 Example 1 39.8±2.9 11.4±1.1 3.5 Comparative Example 1 64.6±4.5 9.5±0.7 6.8 Comparative Example 3 61.7±3.8 9.8±1.2 6.3 Comparative Example 5 62.1±3.2 9.7±0.9 6.4

[0076] Table 2 shows that, compared with the normal group, the plasma cAMP content and cAMP / cGMP ratio of the model group rats were significantly increased, while the cGMP content was significantly decreased. Compared with the model group, the plasma cAMP content and cAMP / cGMP ratio of the rats in Example 1 were significantly decreased, while the cGMP content was significantly increased. Compared with Comparative Examples 1, 3, and 5, the plasma cAMP content and cAMP / cGMP ratio of the rats in Example 1 were significantly decreased, while the cGMP content was significantly increased. This indicates that the synergistic effect of Polygonatum sibiricum, Maca, and Polygonatum odoratum contained in Shenjing Guiyuan Paste has a significant effect of nourishing yin and clearing heat, and can improve the side effects of warm dryness.

[0077] The embodiments described above are merely illustrative of specific implementations of the present invention, and while the descriptions are detailed, they should not be construed as limiting the scope of protection of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention.

Claims

1. A ginseng essence and angelica root extract for invigorating qi and nourishing blood, characterized in that, The ingredients are composed of the following ingredients by weight: 8-12 parts Polygonatum sibiricum, 80-100 parts Lycium barbarum, 4-6 parts Ginseng, 80-100 parts Maca, 0.4-0.6 parts Deer antler velvet, 3-7 parts Polygonatum odoratum, 80-100 parts Mulberry, 80-100 parts Black soybean, 4-6 parts Poria cocos, 40-60 parts Dioscorea opposita, 8-12 parts Lotus seed, 80-100 parts Jujube, 8-12 parts Longan pulp, and 30-50 parts Isomaltooligosaccharide.

2. The ginseng essence and angelica root extract for invigorating qi and nourishing blood according to claim 1, characterized in that, The ingredients are composed of the following ingredients by weight: 10 parts Polygonatum sibiricum, 90 parts Lycium barbarum, 5 parts Ginseng, 90 parts Maca, 0.5 parts Deer antler velvet, 5 parts Polygonatum odoratum, 90 parts Mulberry, 90 parts Black Bean, 5 parts Poria cocos, 50 parts Dioscorea opposita, 10 parts Lotus seed, 90 parts Jujube, 10 parts Longan pulp, and 40 parts Isomaltooligosaccharide.

3. The ginseng essence and angelica root extract for invigorating qi and nourishing blood according to claim 1, characterized in that, The ginseng essence and cinnamon extract paste has the effects of invigorating qi and nourishing blood, nourishing yin and clearing heat.

4. The preparation method of the Qi-tonifying and blood-nourishing Ginseng Essence and Angelica sinensis paste according to claim 1, characterized in that, Includes the following steps: S1. Prepare ingredients according to the formula; S2. Take Polygonatum sibiricum, Lycium barbarum, Ginseng, Maca, Deer antler velvet, Polygonatum odoratum, Mulberry, Black bean, Poria cocos, Dioscorea opposita, Lotus seed, Jujube, and Longan pulp, soak them in water, decoct them three times, and combine the filtrates to obtain the Chinese herbal extract. S3. Add isomaltooligosaccharide to the Chinese herbal extract obtained in step S2, mix and stir well, and then concentrate the paste. When the heated paste is boiling in a "honeycomb" state, the concentrate is ready. While hot, divide into portions, cool and seal to obtain Ginseng Essence and Angelica Essence Paste.

5. The preparation method according to claim 4, characterized in that, In step S2, add water at a ratio of 8-10 times the amount of medicinal materials, soak for 30-40 minutes, and then decoct for 1-2.5 hours.

6. The preparation method according to claim 4, characterized in that, In step S2, for the second and third decoctions, add water at a ratio of 5-7 times the amount of medicinal materials and decoct for 0.5-1.5 hours.

7. The preparation method according to claim 4, characterized in that, The concentration of raw medicinal materials in the Ginseng Essence and Angelica Extract obtained in step S3 is 0.55~0.70g / g.

8. The preparation method according to claim 4, characterized in that, Throughout the process of reducing the paste, keep stirring, skimming off any foam, and preventing it from burning.

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