Dressing with cooling and moisture conducting capabilities and preparation method thereof

Abstract

The invention belongs to the technical field of wound surface dressings, and discloses a dressing with cooling and moisture conducting capabilities and a preparation method thereof. The dressing comprises a radiation refrigeration outer layer and a porous hydrogel inner layer, the radiation refrigeration outer layer comprises an outer layer material and inorganic particles loaded on the outer layer material; the porous hydrogel inner layer is prepared from the following raw materials: carboxymethyl chitosan, bacterial cellulose and tannic acid. According to the dressing with the cooling and moisture guiding capabilities, the environment-friendly composite structure design is innovatively adopted, and intelligent wound nursing is achieved through organic cooperation of multiple layers of functional materials. A double-effect dynamic temperature control system constructed by combining the radiation refrigeration outer layer loaded with inorganic particles on the surface layer with the biocompatible porous hydrogel inner layer can trigger a continuous physical cooling effect when contacting a wound surface, and pain sensitive reaction is effectively relieved by adjusting microenvironment heat balance.

Description

Technical Field

[0001] This invention relates to the field of wound dressing technology, and in particular to a dressing with cooling and moisture-wicking capabilities and its preparation method. Background Technology

[0002] Traditional wound dressings (such as gauze, cotton pads, and non-woven fabrics) are widely used in clinical practice to protect wounds, absorb exudate, and isolate them from external contamination. However, these materials often lead to an imbalance in the wound microenvironment due to insufficient passive moisture absorption or overly occlusive design. On the one hand, occlusive dressings tend to create a high-temperature, high-humidity microenvironment on the wound surface, accelerating local metabolism and promoting bacterial proliferation, thus increasing the risk of infection. On the other hand, traditional materials have limited ability to manage exudate; excessive exudate retention may cause wound maceration, while excessively rapid drying can lead to dehydration of newly formed tissue, delaying the epithelialization process. In addition, traditional dressings lack active temperature control, and increased local wound temperature may exacerbate the inflammatory response and prolong the healing period.

[0003] Currently, dressings mainly focus on regulating their antibacterial, breathable, hemostatic, and moisture-wicking properties. For example, Chinese patent CN119280455A constructs a stable foaming system using proteins and polysaccharides, and further combines multi-source polysaccharides and tannic acid to construct a dual three-dimensional network. This is then used to design a large-area dressing structure by layering it with cotton gauze, and finally, under a weakly acidic environment, Ca... 2+ Cross-linking impregnation and freeze-drying produce a one-piece, three-layer, dual-network, multi-source, porous dressing that can rapidly absorb blood and tissue fluid around the wound, providing extremely fast hemostasis and reducing bleeding. Another example is Chinese patent CN118649271A, which provides a Janus asymmetric moisture-wicking dressing with wound-enhancing properties. This dressing has different hydrophilic and hydrophobic orientations on both sides; the inner coating is hydrophobic, and the outer coating is hydrophilic. This property promotes the directional drainage of wound exudate, maintaining the humidity balance of the wound microenvironment. While these dressings effectively regulate wound humidity, they do not control wound temperature. When used in high-temperature environments or under direct sunlight, their effectiveness on the wound significantly decreases. Summary of the Invention

[0004] The purpose of this invention is to provide a dressing with cooling and moisture-wicking capabilities and a method for preparing the same, thereby solving the aforementioned problems of existing dressings.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0006] The present invention provides a dressing with cooling and moisture-wicking capabilities, comprising a radiation-cooling outer layer and a porous hydrogel inner layer;

[0007] The radiation-cooled outer layer comprises an outer layer material and inorganic particles loaded on the outer layer material.

[0008] Preferably, in the above-mentioned dressing with cooling and moisture-wicking capabilities, the outer layer material is one of cotton pad, non-woven fabric, or gauze.

[0009] Preferably, in the above-mentioned dressing with cooling and moisture-wicking capabilities, the inorganic particles are one of SiO2, ZnO, and TiO2.

[0010] Preferably, in the above-mentioned dressing with cooling and moisture-wicking capabilities, the raw material composition of the porous hydrogel inner layer includes: carboxymethyl chitosan, bacterial cellulose, and tannic acid.

[0011] Preferably, in the above-mentioned dressing with cooling and moisture-wicking capabilities, the basis weight of the radiative cooling outer layer is 20–60 g / m². 2 The basis weight of the porous hydrogel inner layer is 80–300 g / m³. 2 .

[0012] This invention also provides a method for preparing a dressing with cooling and moisture-wicking capabilities, comprising the following steps:

[0013] (1) Preparation of radiation-cooled outer layer: SiO2 precursor, water and anhydrous ethanol are mixed, and then 3-aminopropyltrimethoxysilane is added to obtain a first mixed solution; the outer layer material is immersed in the first mixed solution, and ammonia is added to react to obtain the radiation-cooled outer layer;

[0014] Alternatively, the ZnO precursor and water can be mixed, and then ammonia can be added to obtain a second mixed solution; the outer layer material can be immersed in the second mixed solution to carry out a first hydrothermal reaction to obtain a radiation-cooled outer layer;

[0015] Alternatively, TiO2 precursor and anhydrous ethanol can be mixed, and then acetic acid solution can be added to obtain a third mixed solution; the outer layer material can be immersed in the third mixed solution to carry out a second hydrothermal reaction to obtain a radiation-cooled outer layer;

[0016] (2) Preparation of moisture-wicking hydrogel: Carboxymethyl chitosan, water, and bacterial cellulose are mixed, and then tannic acid solution is added to obtain moisture-wicking hydrogel;

[0017] (3) Preparation of dressing: The moisture-wicking hydrogel is coated on the surface of the radiation cooling outer layer, and after freeze-thaw, a porous hydrogel inner layer is obtained, thus completing the preparation of the dressing with cooling and moisture-wicking capabilities.

[0018] Preferably, in the above preparation method, the precursor of SiO2 is tetraethyl orthosilicate; the precursor of ZnO is one of zinc chloride, zinc acetate, and zinc nitrate; and the precursor of TiO2 is one of tetrabutyl titanate, isobutyl titanate, and isopropyl titanate.

[0019] Preferably, in the above preparation method, the ratio of the SiO2 precursor, 3-aminopropyltrimethoxysilane, and ammonia is 1g:0.6-1.3g:1-1.5mL; and the ratio of the outer layer material and the first mixed solution is 1g:15mL.

[0020] Preferably, in the above preparation method, the mass ratio of bacterial cellulose, carboxymethyl chitosan, and tannic acid in the tannic acid solution is 18-24:10:1-3; and the mass concentration of the tannic acid solution is 10-15%.

[0021] As can be seen from the above technical solution, compared with the prior art, the present invention has the following beneficial effects:

[0022] (1) The dressing of the present invention with cooling and moisture-wicking capabilities innovatively adopts an environmentally friendly composite structure design, and achieves intelligent wound care through the organic synergy of multiple functional materials. The "dual-effect dynamic temperature control system" constructed by the outer layer of radiation cooling with inorganic particles loaded on the surface and the inner layer of biocompatible porous hydrogel can trigger a continuous physical cooling effect when in contact with the wound, and effectively relieve pain sensitivity by regulating the thermal balance of the microenvironment.

[0023] (2) The dressing of this invention adopts a double-layer composite structure. The outer layer uses an in-situ self-assembly process to uniformly load inorganic particles onto the substrate, which are directly generated on or inside the substrate through chemical reactions (such as sol-gel method, precipitation method). This avoids the agglomeration problem caused by physical mixing, enhances the interfacial bonding force, and improves the structural stability. At the same time, this process can precisely control the particle size, loading amount, and distribution density by adjusting the reaction conditions (concentration, pH, temperature, etc.), thereby regulating the solar reflectivity and mid-infrared emissivity of the material and achieving zero-energy cooling. The inner layer constructs a carboxymethyl chitosan-based porous hydrogel, which increases porosity and improves the moisture conduction rate. Combined with evaporative cooling, it forms a dynamic temperature and humidity control system. The dressing of this invention has both cooling performance and excellent mechanical properties, breaking through the limitations of the single function of traditional dressings. It is suitable for complex environments such as high temperature and high humidity, providing a stable microenvironment for wound healing.

[0024] (3) The inner layer of the porous hydrogel of this invention is constructed with a three-dimensional interpenetrating network structure of carboxymethyl chitosan / bacterial cellulose (CMCS / BC). With BC nanofibers as the skeleton, CMCS is embedded in the BC skeleton to form a bicontinuous phase, which ensures efficient directional transport of exudate and avoids secondary infection caused by humid environment. The naturally derived bio-based antibacterial component carboxymethyl chitosan replaces the traditional silver ion additive, eliminating the risk of heavy metal accumulation. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0026] Figure 1 This is a schematic diagram of the structure of the dressing with cooling and moisture-wicking capabilities in Example 1;

[0027] Figure 2 Solar reflectance and mid-infrared emissivity of the cooling and moisture-wicking dressing of Example 1;

[0028] Figure 3 The image shows an infrared thermal image of the cooling and moisture-wicking dressing of Example 1; where (a) is a conventional dressing and (b) is the cooling and moisture-wicking dressing of Example 1. Detailed Implementation

[0029] The present invention provides a dressing with cooling and moisture-wicking capabilities, comprising a radiation-cooling outer layer and a porous hydrogel inner layer.

[0030] In this invention, the radiation-cooled outer layer preferably comprises an outer layer material and inorganic particles loaded on the outer layer material.

[0031] In this invention, the outer layer material is preferably one of cotton padding, non-woven fabric, and gauze, more preferably non-woven fabric or gauze, and even more preferably all-cotton non-woven fabric.

[0032] In this invention, the inorganic particles are preferably one of SiO2, ZnO, and TiO2, more preferably SiO2 or TiO2, and even more preferably SiO2.

[0033] In this invention, the raw material composition of the porous hydrogel inner layer includes: carboxymethyl chitosan, bacterial cellulose, and tannic acid.

[0034] In this invention, the basis weight of the radiative cooling outer layer is preferably 20–60 g / m³. 2 More preferably 30-50 g / m 2 More preferably 40g / m 2 The preferred basis weight of the porous hydrogel inner layer is 80–300 g / m³. 2 More preferably, it is 100-200 g / m 2 More preferably 120g / m 2 .

[0035] This invention also provides a method for preparing a dressing with cooling and moisture-wicking capabilities, comprising the following steps:

[0036] (1) Preparation of radiation-cooled outer layer: SiO2 precursor, water and anhydrous ethanol are mixed, and then 3-aminopropyltrimethoxysilane is added to obtain a first mixed solution; the outer layer material is immersed in the first mixed solution, and ammonia is added to react to obtain the radiation-cooled outer layer;

[0037] Alternatively, the ZnO precursor and water can be mixed, and then ammonia can be added to obtain a second mixed solution; the outer layer material can be immersed in the second mixed solution to carry out a first hydrothermal reaction to obtain a radiation-cooled outer layer;

[0038] Alternatively, TiO2 precursor and anhydrous ethanol can be mixed, and then acetic acid solution can be added to obtain a third mixed solution; the outer layer material can be immersed in the third mixed solution to carry out a second hydrothermal reaction to obtain a radiation-cooled outer layer;

[0039] (2) Preparation of moisture-wicking hydrogel: Carboxymethyl chitosan, water, and bacterial cellulose are mixed, and then tannic acid solution is added to obtain moisture-wicking hydrogel;

[0040] (3) Preparation of dressing: The moisture-wicking hydrogel is coated on the surface of the radiation cooling outer layer, and after freeze-thaw, a porous hydrogel inner layer is obtained, thus completing the preparation of the dressing with cooling and moisture-wicking capabilities.

[0041] In this invention, the precursor of SiO2 is preferably tetraethyl orthosilicate; the precursor of ZnO is preferably one of zinc chloride, zinc acetate, and zinc nitrate, more preferably zinc chloride or zinc acetate, and even more preferably zinc chloride; the precursor of TiO2 is preferably one of tetrabutyl titanate, isobutyl titanate, and isopropyl titanate, more preferably tetrabutyl titanate or isobutyl titanate, and even more preferably tetrabutyl titanate.

[0042] In this invention, the preferred ratio of the SiO2 precursor, 3-aminopropyltrimethoxysilane, and ammonia is 1g:0.6-1.3g:1-1.5mL, more preferably 1g:1-1.3g:1.2-1.5mL, and even more preferably 1g:1.3g:1.5mL.

[0043] In this invention, the mass ratio of water, anhydrous ethanol, and SiO2 precursor is preferably 0.8-1.5:9:0.1-0.6, more preferably 0.9-1.2:9:0.2-0.5, and even more preferably 1:9:0.3.

[0044] In this invention, the preferred ratio of the outer layer material to the first mixed solution is 1g:15mL.

[0045] In this invention, the reaction time is preferably 4 to 8 hours, more preferably 5 to 8 hours, and even more preferably 6 hours.

[0046] In this invention, the reaction process preferably includes allowing the outer layer material to stand at room temperature for 12 to 24 hours after the reaction is completed, more preferably 12 to 18 hours, and even more preferably 12 hours.

[0047] In this invention, the preferred ratio of the ZnO precursor, water, and ammonia is 2g:100mL:5mL.

[0048] In this invention, the preferred ratio of the outer layer material to the second mixed solution is 1g:10mL.

[0049] In this invention, the temperature of the first hydrothermal reaction is preferably 70°C; the time of the first hydrothermal reaction is preferably 9 hours.

[0050] In this invention, after the first hydrothermal reaction is completed, the process further includes washing and drying in an oven at 60°C for 1 hour.

[0051] In this invention, the volume ratio of the TiO2 precursor, anhydrous ethanol, and acetic acid solution is preferably 1:8:4; and the mass concentration of the acetic acid solution is preferably 15%.

[0052] In this invention, the preferred ratio of the outer layer material to the third mixed solution is 1g:10mL.

[0053] In this invention, the temperature of the second hydrothermal reaction is preferably 70°C; the time of the second hydrothermal reaction is preferably 9 hours.

[0054] In this invention, after the second hydrothermal reaction is completed, the process further includes washing and drying in an oven at 60°C for 1 hour.

[0055] In this invention, the mass ratio of bacterial cellulose, carboxymethyl chitosan, and tannic acid in the tannic acid solution is preferably 18-24:10:1-3, more preferably 18-20:10:1-2, and even more preferably 18:10:1; the mass concentration of the tannic acid solution is preferably 10-15%, more preferably 10-12%, and even more preferably 10%.

[0056] In this invention, the preferred mass ratio of carboxymethyl chitosan to water is 1:25.

[0057] In this invention, the method for mixing carboxymethyl chitosan, water, and bacterial cellulose is as follows: first, dissolve carboxymethyl chitosan in water, then add bacterial cellulose, and stir for 2-4 hours.

[0058] In this invention, the freeze-thaw cycle is preferably performed by freezing at -45°C for 8 hours and then placing at room temperature for 2 hours. The freezing at -45°C and the placing at room temperature constitute one cycle, and the cycle is repeated 3 times.

[0059] In this invention, the moisture-wicking hydrogel coated on the surface of the radiation-cooling outer layer is defined as the moisture-wicking hydrogel being coated on one side of the radiation-cooling outer layer.

[0060] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0061] Example 1

[0062] This embodiment provides a method for preparing a dressing with cooling and moisture-wicking capabilities, including the following steps:

[0063] (1) Mix deionized water, anhydrous ethanol and tetraethyl orthosilicate in a mass ratio of 1:9:0.3 and stir magnetically for 30 min to obtain solution A;

[0064] 3-Aminopropyltrimethoxysilane was added to solution A and stirred for 1 hour to obtain solution B. The mass ratio of 3-aminopropyltrimethoxysilane to tetraethyl orthosilicate was 1.3:1.

[0065] The cotton nonwoven fabric is completely immersed in solution B, and the ratio of the cotton nonwoven fabric to solution B is 1g:15ml.

[0066] Divide the ammonia water into two portions and slowly add them dropwise to solution B at 30-minute intervals. Let the reaction proceed for 6 hours. The ratio of ammonia water to tetraethyl orthosilicate is 1.5 ml: 1 g.

[0067] Take out the all-cotton non-woven fabric and let it stand at room temperature for 12 hours to obtain N-SiO2 / all-cotton non-woven fabric material with high solar reflectivity and high mid-infrared emission, which is the radiation cooling outer layer;

[0068] (2) Dissolve carboxymethyl chitosan completely in deionized water to obtain solution C. The mass ratio of carboxymethyl chitosan to deionized water is 1:25.

[0069] Bacterial cellulose was added to solution C and stirred for 2 hours. Then, a 10% tannic acid solution was added dropwise to solution C to obtain a moisture-wicking hydrogel. The mass ratio of bacterial cellulose, carboxymethyl chitosan and tannic acid was 18:10:1.

[0070] (3) The moisture-wicking hydrogel was uniformly coated on the surface of N-SiO2 / cotton nonwoven fabric, and then frozen at -45℃ for 8 hours and placed at room temperature for 2 hours. This process of freezing at -45℃ and placing at room temperature constitutes one cycle. After three cycles, a porous hydrogel inner layer was obtained, thus obtaining a dressing with cooling and moisture-wicking capabilities. A schematic diagram of the dressing structure is shown below. Figure 1 As shown.

[0071] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0072] The dressing with cooling and moisture-wicking capabilities prepared in this embodiment was tested for solar reflectance and mid-infrared emissivity. The results are as follows: Figure 2 As shown, the infrared thermal image during the test is as follows: Figure 3 As shown. By Figure 2 , Figure 3 It is known that the solar reflectance and mid-infrared emissivity of this dressing are both >90%, exhibiting excellent radiative cooling effect. Furthermore, under direct sunlight, it outperforms traditional dressings (Hunan Kefu Medical Technology Development Co., Ltd.). Figure 3 Compared with (a), it has a better cooling effect.

[0073] Example 2

[0074] This embodiment provides a method for preparing a dressing with cooling and moisture-wicking capabilities. See Example 1 for details. The difference is that the mass ratio of bacterial cellulose, carboxymethyl chitosan and tannic acid in step (2) is 24:10:1.

[0075] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2 The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0076] Example 3

[0077] This embodiment provides a method for preparing a dressing with cooling and moisture-wicking capabilities. See Example 1 for details. The difference is that in step (1), the mass ratio of deionized water, anhydrous ethanol and tetraethyl orthosilicate is 1.5:9:0.6, and the reaction time is 4 hours.

[0078] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2 The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0079] Example 4

[0080] This embodiment provides a method for preparing a dressing with cooling and moisture-wicking capabilities. Specifically, refer to Embodiment 1. The difference is that in step (1), the mass ratio of deionized water, anhydrous ethanol, and tetraethyl orthosilicate is 1.5:9:0.6, the reaction time is 8 hours, and the ratio of ammonia to tetraethyl orthosilicate is 1 ml:1 g. In step (2), the mass ratio of bacterial cellulose, carboxymethyl chitosan, and tannic acid is 24:10:1.5, and the time for stirring the bacterial cellulose in solution C is 4 hours.

[0081] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2 The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0082] Example 5

[0083] (1) Add tetrabutyl titanate slowly dropwise to anhydrous ethanol and stir for 30 min. The volume ratio of tetrabutyl titanate to anhydrous ethanol is 1:8.

[0084] Add dropwise a 15% acetic acid aqueous solution to obtain solution D, where the volume ratio of acetic acid aqueous solution to anhydrous ethanol is 1:2.

[0085] The cotton nonwoven fabric is immersed in solution D, with a ratio of 1g:10ml. The hydrothermal reaction is carried out at 70℃ for 9 hours. After the reaction is completed, the fabric is washed and dried in an oven at 60℃ for 1 hour to obtain a nonwoven fabric material with nano-titanium dioxide particles that have high reflectivity to sunlight and high emission in the mid-infrared, which is the radiation cooling outer layer.

[0086] (2) Dissolve carboxymethyl chitosan completely in deionized water to obtain solution C. The mass ratio of carboxymethyl chitosan to deionized water is 1:25.

[0087] Bacterial cellulose was added to solution C and stirred for 2 hours. Then, a 10% tannic acid solution was added dropwise to solution C to obtain a moisture-wicking hydrogel. The mass ratio of bacterial cellulose, carboxymethyl chitosan and tannic acid was 18:10:1.

[0088] (3) The moisture-wicking hydrogel is uniformly coated on the outer surface of the radiation cooling layer, frozen at -45℃ for 8 hours, and placed at room temperature for 2 hours. The freezing at -45℃ and the placement at room temperature constitute one cycle. After three cycles, a porous hydrogel inner layer is obtained, which is a dressing with cooling and moisture-wicking capabilities.

[0089] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2 The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0090] Example 6

[0091] (1) Mix zinc chloride and water evenly to obtain solution E; add 28% ammonia water dropwise to solution E and stir for 2 hours to obtain solution F. The ratio of zinc chloride to water is 2g:100ml, and the volume ratio of ammonia water to solution E is 1:20.

[0092] Add all-cotton nonwoven fabric to solution F and stir for 1 hour. The ratio of all-cotton nonwoven fabric to solution F is 1g:10ml. Perform hydrothermal reaction at 70℃ for 9 hours. After the reaction is completed, wash and dry in an oven at 60℃ for 1 hour to obtain nonwoven fabric material with high solar reflectivity and high mid-infrared emission of nano zinc oxide particles, which is the radiation cooling outer layer.

[0093] (2) Dissolve carboxymethyl chitosan completely in deionized water to obtain solution C. The mass ratio of carboxymethyl chitosan to deionized water is 1:25.

[0094] Bacterial cellulose was added to solution C and stirred for 2 hours. Then, a 10% tannic acid solution was added dropwise to solution C to obtain a moisture-wicking hydrogel. The mass ratio of bacterial cellulose, carboxymethyl chitosan and tannic acid was 18:10:1.

[0095] (3) The moisture-wicking hydrogel is uniformly coated on the outer surface of the radiation cooling layer, frozen at -45℃ for 8 hours, and placed at room temperature for 2 hours. The freezing at -45℃ and the placement at room temperature constitute one cycle. After three cycles, a porous hydrogel inner layer is obtained, which is a dressing with cooling and moisture-wicking capabilities.

[0096] The outer radiant cooling layer of the dressing with cooling and moisture-wicking capabilities in this embodiment has a weight of 40 g / m². 2 The basis weight of the porous hydrogel inner layer is 120 g / m³. 2 .

[0097] Comparative Example 1

[0098] This comparative example provides a method for preparing a dressing, specifically referring to Example 1, except that steps (2) and (3) are omitted, i.e., the radiation-cooled outer layer is the dressing.

[0099] Comparative Example 2

[0100] This comparative example provides a method for preparing a dressing, specifically referring to Example 1. The difference is that steps (1) and (3) are omitted, i.e., the moisture-wicking hydrogel is frozen at 45°C for 8 hours and placed at room temperature for 2 hours. Freezing at -45°C and placing at room temperature constitutes one cycle. After three cycles, the porous hydrogel inner layer obtained is the dressing.

[0101] The cooling, antibacterial, and moisture-wicking properties of the dressings prepared in Examples 1-6 and Comparative Examples 1-2 were tested, and the test results are as follows:

[0102] Cooling performance test: Outdoor experiments were conducted on a sunny day to comprehensively examine the cooling performance of the dressing. The samples were placed individually in an insulating foam box covered with aluminum foil, with internal dimensions of 60*60*20mm. The top surface of the foam box was covered with a 10μm thick porous polyethylene film to reduce the influence of wind and allow moisture diffusion. The results are shown in Table 1.

[0103] Table 1 Results of Dressing Cooling Test

[0104]

[0105] As shown in Table 1, the cooling effect of the dressing of the present invention, resulting from the synergistic effect of radiative and evaporative cooling, is superior to that of either effect alone during use. According to the results of Comparative Examples 1 and 2, the radiative cooling effect of the dressing of the present invention has a greater impact on cooling than evaporative cooling during use.

[0106] Antibacterial performance test: The antibacterial effect of the cotton fabric against Escherichia coli and Staphylococcus aureus was characterized by the plating method. 6.4 g of agar was added to 200 mL of deionized water and sterilized in an autoclave to prepare a solid culture medium. 500 μL of the original bacterial solution was added to 5 mL of liquid culture medium and shaken at 150 rpm for 18 h at 37°C to prepare initial bacterial solution a. 715 μL of initial bacterial solution a was added to 10 mL of PBS buffer, followed by 0.2 g of dressing, and shaken at 150 rpm for 18 h at 25°C to prepare sample bacterial solution b. 100 μL of sample bacterial solution b was added to 900 μL of PBS solution, mixed thoroughly, and then diluted 10 times. -5 From 10 -5 100 μL of diluted bacterial solution was pipetted into a solid culture medium and incubated at 37°C for 24 h. Bacterial growth was observed. The antibacterial rate of the fabric was calculated according to formula (1), and the results are shown in Table 2.

[0107]

[0108] In the formula, A represents the colony count of the control sample, and B represents the colony count of the test sample.

[0109] Table 2 Results of antibacterial rate of dressings

[0110] sample Antibacterial rate (%) Example 1 99.99 Example 2 99.99 Example 3 99.99 Example 4 99.99 Example 5 99.99 Example 6 99.99 Comparative Example 1 99.13 Comparative Example 2 99.99

[0111] As shown in Table 2, both layers of the dressing of this invention exhibit good antibacterial properties. According to Examples 1-6, variations in preparation conditions have minimal impact on its antibacterial properties. Therefore, this invention, through the composite design of a radiation-cooled outer layer and a moisture-wicking hydrogel, can produce a wound dressing with excellent antibacterial effects, and the preparation method is simple and convenient for large-scale application.

[0112] To prevent persistent wound infection caused by tissue fluid buildup, a moisture-wicking test was performed on the dressing, and the results are shown in Table 3.

[0113] Table 3 Results of the moisture-wicking properties of the dressing

[0114]

[0115]

[0116] As can be seen from Table 3, the dressing benefits from the three-dimensional interpenetrating network structure of its inner hydrogel, which improves its moisture-wicking properties and helps to accelerate the healing speed of the wound.

[0117] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A dressing with cooling and moisture-wicking capabilities, characterized in that, It includes a radiation-cooled outer layer and a porous hydrogel inner layer; The radiation-cooled outer layer comprises an outer layer material and inorganic particles loaded on the outer layer material.

2. The dressing with cooling and moisture-wicking capabilities according to claim 1, characterized in that, The outer layer material is one of cotton padding, non-woven fabric, or gauze.

3. A dressing with cooling and moisture-wicking capabilities according to claim 2, characterized in that, The inorganic particles are one of SiO2, ZnO, and TiO2.

4. A dressing with cooling and moisture-wicking capabilities according to claim 1 or 3, characterized in that, The raw material composition of the inner layer of the porous hydrogel includes: carboxymethyl chitosan, bacterial cellulose, and tannic acid.

5. A dressing with cooling and moisture-wicking capabilities according to claim 4, characterized in that, The weight of the radiation-cooling outer layer is 20–60 g / m². 2 The basis weight of the porous hydrogel inner layer is 80–300 g / m³. 2 .

6. A method for preparing a dressing with cooling and moisture-wicking capabilities as described in any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Preparation of radiation-cooled outer layer: SiO2 precursor, water and anhydrous ethanol are mixed, and then 3-aminopropyltrimethoxysilane is added to obtain a first mixed solution; the outer layer material is immersed in the first mixed solution, and ammonia is added to react to obtain the radiation-cooled outer layer; Alternatively, the ZnO precursor and water can be mixed, and then ammonia can be added to obtain a second mixed solution; the outer layer material can be immersed in the second mixed solution to carry out a first hydrothermal reaction to obtain a radiation-cooled outer layer; Alternatively, TiO2 precursor and anhydrous ethanol can be mixed, and then acetic acid solution can be added to obtain a third mixed solution; the outer layer material can be immersed in the third mixed solution to carry out a second hydrothermal reaction to obtain a radiation-cooled outer layer; (2) Preparation of moisture-wicking hydrogel: Carboxymethyl chitosan, water, and bacterial cellulose are mixed, and then tannic acid solution is added to obtain moisture-wicking hydrogel; (3) Preparation of dressing: The moisture-wicking hydrogel is coated on the surface of the radiation cooling outer layer, and after freeze-thaw, a porous hydrogel inner layer is obtained, thus completing the preparation of the dressing with cooling and moisture-wicking capabilities.

7. A method for preparing a dressing with cooling and moisture-wicking capabilities according to claim 6, characterized in that, The precursor of SiO2 is tetraethyl orthosilicate; the precursor of ZnO is one of zinc chloride, zinc acetate, and zinc nitrate; the precursor of TiO2 is one of tetrabutyl titanate, isobutyl titanate, and isopropyl titanate.

8. A method for preparing a dressing with cooling and moisture-wicking capabilities according to claim 7, characterized in that, The ratio of the SiO2 precursor, 3-aminopropyltrimethoxysilane, and ammonia is 1g:0.6-1.3g:1-1.5mL; the ratio of the outer layer material and the first mixed solution is 1g:15mL.

9. A method for preparing a dressing with cooling and moisture-wicking capabilities according to claim 8, characterized in that, The mass ratio of bacterial cellulose, carboxymethyl chitosan, and tannic acid in the tannic acid solution is 18–24:10:1–3; the mass concentration of the tannic acid solution is 10–15%.

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