Pulse ablation control system

Abstract

The invention relates to the field of pulse ablation control, and provides a pulse ablation control system which comprises a pulse generating device and an ablation electrode module, and the pulse generating device comprises an input power supply module, an electric energy storage module, a pulse control module, an ablation electrode control module and a man-machine interaction module and is used for generating high-voltage pulse current. The pulse control module is used for controlling generation of high-voltage pulse current, the input power supply module is used for providing electric energy required by the electric energy storage module, the electric energy storage module is used for outputting high-voltage pulse, the man-machine interaction module is used for inputting detailed information of pulse treatment, and the ablation electrode module comprises a plurality of electrode slices connected to focus tissue of a patient. Therefore, targeted ablation is realized. According to the method, the action area can be accurately controlled by using pulse ablation, the influence on tissues outside the action area is reduced, so that the damage to adjacent tissues is reduced, the used time is greatly shortened compared with a traditional means, and the ablation process is safer and more efficient.

Description

Technical Field

[0001] This invention relates to the field of pulse ablation control, specifically a pulse ablation control system. Background Technology

[0002] Pulsed ablation is a new technology applied in the medical field. It refers to applying a high-voltage electrical pulse to the phospholipid bilayer of the cell membrane for a short period of time, generating a transmembrane potential and forming an unstable potential. As a result, the cell membrane suffers irreversible permeability loss and generates nanoscale voids, which in turn causes changes in cell membrane permeability, thereby disrupting the homeostasis of the intracellular environment and ultimately leading to apoptosis. This achieves the purpose of non-thermal ablation. Currently, pulsed ablation is used as an effective means of destroying malignant tumor tissue and is gradually being applied to the treatment of atrial fibrillation.

[0003] The existing technical solutions have the following problems: 1. Currently, mainstream ablation techniques are divided into two categories: radiofrequency ablation and cryoablation. Radiofrequency ablation destroys lesions by generating a resistive electrothermal effect in myocardial tissue, but at the same time, the range of action is too large, making it difficult to precisely remove lesions. Cryoablation destroys lesions by freezing the lesion tissue at ultra-low temperatures, but at the same time, the freezing time is difficult to control precisely, which may damage the surrounding tissues of the lesion.

[0004] 2. The current mainstream technical solution is to generate pulse current through a single-stage pulse generator circuit. However, the single-stage pulse generator circuit is bulky and difficult to miniaturize. At the same time, it is difficult to suppress and shape the corona discharge caused by the generation of pulse voltage, and the control of pulse voltage and current is relatively difficult. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention provides a pulse ablation control system to solve issues such as inaccurate ablation and excessively large ablation range in existing technologies.

[0006] A pulse ablation control system includes: a pulse generator and an ablation electrode module; The pulse generating device includes an input power module, an energy storage module, a pulse control module, an ablation electrode control module, and a human-machine interaction module, used to generate high-voltage pulse current; The pulse control module is connected to the input power module, the energy storage module and the human-machine interaction module respectively, and is used to control the generation of high-voltage pulse current; The input power module is connected to the energy storage module and is used to provide the energy required by the energy storage module. The energy storage module is connected to the pulse control module and is used to provide the energy required for pulse generation and output high-voltage pulses; The human-computer interaction module is connected to the pulse control module and is used to input detailed pulse therapy information; The ablation electrode module is coupled to the pulse control module and includes multiple electrode pads connected to the patient's lesion tissue, thereby releasing high-voltage pulses in a targeted manner to achieve ablation.

[0007] Preferably, the human-computer interaction module receives patient information and detailed treatment information set by the user, and transmits the detailed treatment information to the pulse control module; Detailed treatment information includes treatment parameters, output voltage parameters, output electrode pair serial numbers, and treatment sites; The pulse control module feeds back the pulse control parameters to the human-machine interface module, which displays the release voltage, impedance value, and ablation status.

[0008] Preferably, the pulse control module receives treatment information transmitted by the human-machine interaction module and generates pulse control parameters based on the treatment information; The pulse control module outputs pulse control parameters to the input power module, the energy storage module, and the ablation electrode control module; The pulse control parameters include pulse voltage parameters, number of pulses, number of pulse groups, pulse interval, pulse width, pulse period, and control signals for the ablation electrode pair.

[0009] Preferably, the input power module is used to receive control signals and detailed voltage setting parameters output by the pulse control module, convert the mains power connected to the input power module into DC power of a specified voltage value, and output current of a specified voltage value to the energy storage module for energy storage.

[0010] Preferably, the energy storage module is used to receive the current output by the input power module and input the current to the Max pulse generator circuit; The Marx pulse generator circuit charges multiple capacitors in parallel and then discharges them in series through a switching switch, thereby achieving energy storage and conversion from low-voltage DC to high-voltage DC. The energy storage module receives the pulse control parameters output by the pulse control module, and controls the switching of the switches in the Max pulse generator circuit according to the pulse control parameters, thereby achieving the output of a specified pulse current.

[0011] Preferably, the pulse control module controls the pulse generation process as follows: First, obtain the rise time of the target pulse current. The number of capacitors in the pulse circuit This allows for the calculation of the discharge interval between adjacent capacitors. The calculation formula is as follows:

[0012] Secondly, the circuit switch driving voltage gradient function is calculated. This function is used to control the switching speed within the Max pulse generator circuit and suppress electromagnetic interference (EMI). EMI is high-frequency electromagnetic interference generated during the closing of the switch and the series discharge of the capacitor within the circuit. The circuit switch driving voltage gradient function is as follows:

[0013] in, The voltage gradient function driving the circuit switch. The switch number in the circuit; Then, the circuit switch switching timing equation is established. This circuit switch switching timing equation is used to control the precise timing triggering of the circuit switch. The establishment process is as follows:

[0014] in, It is the first Stage circuit switch switching time; Finally, calculate the first... The pulse current, voltage, and current released during the switching of the stage are calculated using the following formulas: Voltage calculation formula:

[0015] in, The switch number in the circuit. It is the first in the circuit The operating voltage of each capacitor; Current calculation formula:

[0016] in, R is the pulse current value released when the kth switch is turned on, and R is the line resistance value in the Max pulse generator circuit. Preferably, the pulse generation process of the Marx pulse generator circuit is as follows: First, the energy storage module receives the pulse voltage and current transmitted by the pulse control module. Based on the pulse voltage and current, and combined with the pulse current voltage and current calculation formula released by the k-th stage switch switching, the energy storage module calculates the capacitor sequence number that needs to be turned on for pulse release. Next, the discharge interval between capacitors is calculated based on the discharge interval between adjacent capacitors. Finally, the voltage value required for the corresponding switch to turn on and the switching time are calculated based on the circuit switch driving voltage gradient function and the circuit switch switching timing equation.

[0017] Preferably, the ablation electrode control module receives the pulse control parameters output by the pulse control module, and, based on the ablation electrode pair control signal in the pulse control parameters, implements time-division and zone-based discharge control for multiple ablation electrode pairs through an independently controllable power switching unit; Preferably, the pulse voltage parameter setting process includes: setting the voltage value in the human-machine interaction module, and transmitting and sending the voltage value to the pulse control module; The pulse control module controls the output voltage of the input power module to charge the energy storage module.

[0018] Preferably, the pulse control module detects whether the human-machine interaction module, the energy storage module, and the ablation electrode module are operating normally; if the detection is normal, the human-machine interaction module, the energy storage module, and the ablation electrode module operate normally; if the detection is abnormal, the pulse control module sends an abnormal operation command to the human-machine interaction module, and the human-machine interaction module displays an alarm signal.

[0019] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention uses pulsed ablation to precisely control the target area, reducing the impact on tissues outside the target area, thereby reducing damage to adjacent tissues and making it safer. Pulsed ablation reduces ablation time, greatly shortening the time required compared to traditional methods, effectively reducing surgical time and making the ablation process safer and more efficient.

[0020] 2. By applying the Max pulse generation circuit, this invention can reduce the size of the equipment and achieve miniaturization. At the same time, it reduces the voltage instability during the pulse generation process of the unipolar pulse circuit, and can effectively achieve stable high voltage output and constant current release. Attached Figure Description

[0021] Figure 1 This is a flowchart of the workflow of the present invention.

[0022] Figure 2 This is a diagram showing the relationships between the modules of this invention. Detailed Implementation

[0023] The embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of the invention.

[0024] This invention provides a pulse ablation control system, characterized in that it includes: a pulse generator and an ablation electrode module; The pulse generator includes an input power module, an energy storage module, a pulse control module, an ablation electrode control module, and a human-machine interface module, used to generate high-voltage pulse current; The pulse control module is connected to the input power module, the energy storage module and the human-machine interaction module respectively, and is used to control the generation of high-voltage pulse current; The input power module is connected to the energy storage module to provide the energy required by the energy storage module; The energy storage module is connected to the pulse control module to provide the energy required for pulse generation and output high-voltage pulses; The human-computer interaction module is connected to the pulse control module and is used to input detailed pulse therapy information; The ablation electrode module is coupled to the pulse control module and includes multiple electrode pads that are connected to the patient's lesion tissue to release high-voltage pulses in a targeted manner to achieve ablation.

[0025] Example: like Figure 1 - Figure 2 As shown in this embodiment, in the process of manufacturing pulse ablation equipment, a medical device manufacturer finds that the traditional single-unit pulse generation circuit is difficult to reduce in size, making it difficult to miniaturize the pulse ablation equipment and meet the market demand for miniaturized medical equipment. At the same time, the pulse current and voltage generated by the single-unit pulse circuit are unstable, which will affect the medical effect. Therefore, this system is used to manufacture pulse ablation equipment. The pulse ablation equipment includes a pulse generation device and an ablation electrode module. The pulse generator includes an input power module, an energy storage module, a pulse control module, an ablation electrode control module, and a human-machine interface module, used to generate high-voltage pulse current; The pulse control module is connected to the input power module, the energy storage module and the human-machine interaction module respectively, and is used to control the generation of high-voltage pulse current; The input power module is connected to the energy storage module to provide the energy required by the energy storage module; The energy storage module is connected to the pulse control module to provide the energy required for pulse generation and output high-voltage pulses; The human-computer interaction module is connected to the pulse control module and is used to input detailed pulse therapy information; The ablation electrode module is coupled to the pulse control module and includes multiple electrode pads that are connected to the patient's lesion tissue to release high-voltage pulses in a targeted manner to achieve ablation.

[0026] The human-computer interaction module receives patient information and detailed treatment information set by the user, and transmits the detailed treatment information to the pulse control module; Detailed treatment information includes treatment parameters, output voltage parameters, output electrode pair serial numbers, and treatment sites; The pulse control module feeds back pulse signals to the human-machine interface module, which displays the release voltage, impedance value, and ablation status.

[0027] Users can operate the device intuitively through the human-computer interaction module. The device can autonomously select the pulse output strategy based on the information input by the user, thereby effectively reducing the difficulty of using the device.

[0028] The pulse control module receives treatment information transmitted from the human-machine interaction module and generates pulse control parameters based on the treatment information; The pulse control module outputs pulse control parameters to the input power module, the energy storage module, and the ablation electrode control module; The pulse control parameters include pulse voltage parameters, number of pulses, number of pulse groups, pulse interval, pulse width, pulse period, and control signals for the ablation electrode pair.

[0029] The pulse control module inside the device can achieve precise pulse output. Based on the treatment information input by the user, the module can correctly select the corresponding pulse output scheme, thereby selecting the correct pulse voltage, number and pulse interval, so as to effectively achieve the ablation expectation.

[0030] The input power module receives control signals and detailed voltage setting parameters from the pulse control module, converts the AC power connected to the input power module into DC power of a specified voltage value, and outputs a current of a specified voltage value to the energy storage module for energy storage.

[0031] The energy storage module is used to receive the current output from the input power module and input the current to the Max pulse generator circuit; The Marx pulse generator circuit charges multiple capacitors in parallel and then discharges them in series through a switching switch, thereby achieving energy storage and conversion from low-voltage DC to high-voltage DC. The energy storage module receives the pulse control parameters output by the pulse control module, and controls the switching of the switches in the Max pulse generator circuit according to the pulse control parameters, thereby achieving the output of a specified pulse current.

[0032] The pulse generation process controlled by the pulse control module is as follows: First, obtain the rise time of the target pulse current. The number of capacitors in the pulse circuit This allows for the calculation of the discharge interval between adjacent capacitors. The calculation formula is as follows:

[0033] Secondly, the circuit switch driving voltage gradient function is calculated. This function is used to control the switching speed within the Max pulse generator circuit and suppress electromagnetic interference (EMI). EMI is high-frequency electromagnetic interference generated during the closing of the switch and the series discharge of the capacitor within the circuit. The circuit switch driving voltage gradient function is as follows:

[0034] in, The voltage gradient function driving the circuit switch. The switch number in the circuit; Then, the circuit switch switching timing equation is established. This circuit switch switching timing equation is used to control the precise timing triggering of the circuit switch. The establishment process is as follows:

[0035] in, It is the switching time of the k-th level circuit; Finally, the pulse current voltage and current released during the switching of the k-th stage are calculated using the following formula: Voltage calculation formula:

[0036] in, The switch number in the circuit. It is the first in the circuit The operating voltage of each capacitor; Current calculation formula:

[0037] in, R is the pulse current value released when the kth switch is turned on, and R is the line resistance value in the Max pulse generator circuit. The process by which the Marx pulse generator circuit generates pulses is as follows: First, the energy storage module receives the pulse voltage and current transmitted by the pulse control module. Based on the pulse voltage and current, and combined with the pulse current voltage and current calculation formula released by the k-th stage switch switching, the energy storage module calculates the capacitor sequence number that needs to be turned on for pulse release. Next, the discharge interval between capacitors is calculated based on the discharge interval between adjacent capacitors. Finally, the voltage value required for the corresponding switch to turn on and the switching time are calculated based on the circuit switch driving voltage gradient function and the circuit switch switching timing equation.

[0038] Through the above pulse current control process, the energy storage module can output the pulse current and voltage input by the pulse control module to achieve the specified voltage and current pulse output.

[0039] The ablation electrode control module receives the pulse control parameters output by the pulse control module, and, based on the ablation electrode pair control signals in the pulse control parameters, implements time-division and zone-division discharge control for multiple ablation electrode pairs through an independently controllable power switching unit. The input power module and energy storage module are responsible for power conversion and high-voltage pulse generation. By converting AC power into DC power at the target voltage, and through the Max pulse generator circuit, they can effectively store energy and provide the pulse voltage and pulse interval required by the pulse control module.

[0040] The pulse voltage parameters include: setting the voltage value in the human-machine interaction module, and transmitting and sending the voltage value to the pulse control module; The pulse control module controls the output voltage of the input power module to charge the energy storage module.

[0041] The ablation electrode control module receives the pulse control parameters output by the pulse control module, and, based on the ablation electrode pair control signals in the pulse control parameters, implements time-division and zone-division discharge control for multiple ablation electrode pairs through an independently controllable power switching unit. The ablation electrode control module achieves precise regional ablation by controlling the discharge sequence of the ablation electrode pairs, and at the same time, it precisely controls the sequence number of the discharge electrode pairs, effectively realizing the precise control of the discharge electrode pairs.

[0042] The pulse control module checks whether the human-machine interaction module, the energy storage module, and the ablation electrode module are operating normally. If the detection is normal, the human-machine interaction module, the energy storage module, and the ablation electrode module operate normally. If the detection is abnormal, the pulse control module sends an abnormal operation command to the human-machine interaction module, and the human-machine interaction module displays an alarm signal.

[0043] The self-test function of the pulse control module effectively determines the operating status of the equipment, thereby providing corresponding early warnings before a fault occurs, thus avoiding treatment accidents caused by equipment failure and ensuring treatment effectiveness.

[0044] The embodiments of the present invention are given for the purposes of illustration and description. Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A pulse ablation control system, characterized in that, include: Pulse generator and ablation electrode module; The pulse generating device includes an input power module, an energy storage module, a pulse control module, an ablation electrode control module, and a human-machine interaction module, used to generate high-voltage pulse current; The pulse control module is connected to the input power module, the energy storage module and the human-machine interaction module, and is used to control the generation of high-voltage pulse current. The input power module is connected to the energy storage module and is used to provide the energy required by the energy storage module; The energy storage module is connected to the pulse control module and is used to provide the energy required for pulse generation and output high-voltage pulses; The human-computer interaction module is connected to the pulse control module and is used to input detailed pulse therapy information; The ablation electrode module is coupled to the pulse control module and includes multiple electrode pads connected to the patient's lesion tissue, thereby releasing high-voltage pulses in a targeted manner to achieve ablation.

2. The pulse ablation control system as claimed in claim 1, characterized in that: The human-computer interaction module receives detailed treatment information set by the user and transmits the detailed treatment information to the pulse control module; The detailed treatment information includes treatment parameters, output voltage parameters, output electrode pair numbers, and treatment sites; The pulse control module feeds back pulse control parameters to the human-machine interaction module, which displays the release voltage, impedance value, and ablation status.

3. The pulse ablation control system as described in claim 2, characterized in that: The pulse control module receives treatment information transmitted by the human-computer interaction module and generates pulse control parameters based on the treatment information. The pulse control module outputs pulse control parameters to the input power module, the energy storage module, and the ablation electrode control module; The pulse control parameters include pulse voltage parameters, number of pulses, number of pulse groups, pulse interval, pulse width, pulse period, and control signals for the ablation electrode pair.

4. The pulse ablation control system as described in claim 3, characterized in that: The input power module is used to receive control signals and detailed voltage setting parameters output by the pulse control module, convert the mains power connected to the input power module into DC power of a specified voltage value, and output current of a specified voltage value to the energy storage module for energy storage.

5. The pulse ablation control system as described in claim 3, characterized in that: The energy storage module is used to receive the current output by the input power module and input the current to the Max pulse generator circuit; The Marx pulse generator circuit is to charge multiple capacitors in parallel and then discharge them in series through a switching switch, thereby realizing energy storage and conversion from low-voltage DC to high-voltage DC. The energy storage module receives pulse control parameters output by the pulse control module and controls the switching of the switches in the Max pulse generator circuit according to the pulse control parameters, thereby achieving the output of a specified pulse current.

6. The pulse ablation control system as claimed in claim 3, characterized in that: The pulse control module controls the pulse generation process as follows: First, obtain the rise time of the target pulse current. The number of capacitors in the pulse circuit This allows for the calculation of the discharge interval between adjacent capacitors. The calculation formula is as follows: Secondly, the circuit switch driving voltage gradient function is calculated. This function is used to control the switching speed within the Max pulse generator circuit and suppress electromagnetic interference (EMI). EMI is high-frequency electromagnetic interference generated during the closing of the switch and the series discharge of the capacitor within the circuit. The circuit switch driving voltage gradient function is as follows: in, The voltage gradient function driving the circuit switch. The switch number in the circuit; Then, the circuit switch switching timing equation is established. This circuit switch switching timing equation is used to control the precise timing triggering of the circuit switch. The establishment process is as follows: in, It is the switching time of the k-th level circuit; Finally, the pulse current voltage and current released during the switching of the k-th stage are calculated using the following formula: Voltage calculation formula: in, The switch number in the circuit. It is the first in the circuit The operating voltage of each capacitor; Current calculation formula: in, Is it the start of the first The pulse current value released by each switch, This represents the circuit resistance value in the Marx pulse generator circuit.

7. The pulse ablation control system as claimed in claim 6, characterized in that: The process by which the Marx pulse generator circuit generates pulses is as follows: First, the energy storage module receives the pulse voltage and current transmitted by the pulse control module. Based on the pulse voltage and current, and combined with the pulse current voltage and current calculation formula released by the k-th level switch switching, the energy storage module calculates the capacitor sequence number that needs to be turned on for pulse release. Then, the discharge interval between capacitors is calculated based on the discharge interval between adjacent capacitors. Finally, the voltage value required to turn on the corresponding switch and the switching time are calculated based on the circuit switch driving voltage gradient function and the circuit switch switching timing equation.

8. The pulse ablation control system as claimed in claim 3, characterized in that: The ablation electrode control module receives the pulse control parameters output by the pulse control module, and, based on the ablation electrode pair control signals in the pulse control parameters, implements time-division and zone-based discharge control for multiple ablation electrode pairs through an independently controllable power switching unit.

9. The pulse ablation control system as claimed in claim 3, characterized in that: Setting the pulse voltage parameters includes: setting a voltage value in the human-machine interaction unit, and transmitting and sending the voltage value to the pulse control module; The pulse control module controls the output voltage value of the input power module to charge the energy storage module.

10. A pulse ablation control system as claimed in claim 3, characterized in that: The pulse control module checks whether the human-machine interaction module, the energy storage module, and the ablation electrode module are operating normally; if the detection is normal, the human-machine interaction module, the energy storage module, and the ablation electrode module are operating normally. If the detection is abnormal, the pulse control module sends an abnormal operation command to the human-machine interaction module, and the human-machine interaction module displays an alarm signal.

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